Jackrong/Qwen3.5-4B-Claude-4.6-Opus-Reasoning-Distilled-GGUF
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š§Ŗ Open Discovery Challenge ā Season 4 is open: non-opioid pain
WHO titled its 2023 report "Left behind in pain."
The same drug kills by excess in one part of the world and, by its absence, lets people die in agony elsewhere. About 80% of the ~600,000 drug-related deaths WHO estimated for 2019 involved opioids. The same report records a 5-fold to 63-fold gap in morphine consumption between rich and poor countries: the richest 10% use 90% of what circulates. Everyone else endures surgery, and terminal cancer, without it.
Both problems have one answer: a painkiller that does not create dependence.
Nav1.7 has come closest. People born without a working copy of this channel feel no pain while every other sensation stays normal ā validated not in animals but in humans.
There is still no drug, and the difficulty is not the target but the discrimination. The body carries several similar sodium channels, and blocking the heart's hERG channel alongside causes fatal arrhythmia. Several candidates were discontinued for exactly that.
Season 4 asks one question: can you block the pain channel alone?
Target ā Nav1.7 VSD4, the domain IV voltage sensor where this inhibitor class binds
Anti-target ā hERG pore, computed as the tetramer: four subunits together form the space a drug enters, and a monomer misses the binders that matter.
Closes 2027-01-31 Ā· Prize USD 1,000 to the season's #1
Any model, any harness. However you found the candidate, it meets the same rubric.
14 days, 9,886 candidates, 108 participants
ODC opened on 2026-08-15. In the fourteen days since, 9,886 candidate molecules have come from 108 participants across four seasons ā malaria, tuberculosis, Chagas disease, and now non-opioid pain. About 700 a day, from people who mostly do not know each other.
The candidates are the point. The leaderboard is only how we keep score.
š FINAL-Bench/open-discovery-challenge
WHO titled its 2023 report "Left behind in pain."
The same drug kills by excess in one part of the world and, by its absence, lets people die in agony elsewhere. About 80% of the ~600,000 drug-related deaths WHO estimated for 2019 involved opioids. The same report records a 5-fold to 63-fold gap in morphine consumption between rich and poor countries: the richest 10% use 90% of what circulates. Everyone else endures surgery, and terminal cancer, without it.
Both problems have one answer: a painkiller that does not create dependence.
Nav1.7 has come closest. People born without a working copy of this channel feel no pain while every other sensation stays normal ā validated not in animals but in humans.
There is still no drug, and the difficulty is not the target but the discrimination. The body carries several similar sodium channels, and blocking the heart's hERG channel alongside causes fatal arrhythmia. Several candidates were discontinued for exactly that.
Season 4 asks one question: can you block the pain channel alone?
Target ā Nav1.7 VSD4, the domain IV voltage sensor where this inhibitor class binds
Anti-target ā hERG pore, computed as the tetramer: four subunits together form the space a drug enters, and a monomer misses the binders that matter.
Closes 2027-01-31 Ā· Prize USD 1,000 to the season's #1
Any model, any harness. However you found the candidate, it meets the same rubric.
14 days, 9,886 candidates, 108 participants
ODC opened on 2026-08-15. In the fourteen days since, 9,886 candidate molecules have come from 108 participants across four seasons ā malaria, tuberculosis, Chagas disease, and now non-opioid pain. About 700 a day, from people who mostly do not know each other.
The candidates are the point. The leaderboard is only how we keep score.
š FINAL-Bench/open-discovery-challenge
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Introducing nono: A Secure Sandbox for AI Agents
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