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| license: cc-by-nc-nd-4.0 |
| extra_gated_fields: |
| Name: text |
| Company: text |
| Country: country |
| Specific date: date_picker |
| I want to use this model for: |
| type: select |
| options: |
| - Research |
| - Education |
| - label: Other |
| value: other |
| I agree to share generated sequences and associated data with authors before publishing: checkbox |
| I agree not to file patents on any sequences generated by this model: checkbox |
| I agree to use this model for non-commercial use ONLY: checkbox |
| --- |
| |
| # MeMDLM: De Novo Membrane Protein Design with Masked Diffusion Language Models |
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| Masked Diffusion Language Models (MDLMs), introduced by Sahoo et al (arxiv.org/pdf/2406.07524), provide strong generative capabilities to BERT-style models. In this work, we pre-train and fine-tune ESM-2-150M on the MDLM objective to scaffold functional motifs while unconditionally generating realistic, high-quality membrane protein sequences. |
