PhaseFlow

This repository hosts the unified PhaseFlow runtime checkpoint used for peptide phase prediction, full-length protein LLPS prediction, and droplet-promoting region (DPR) localization.

Component	Task	Embedded weights
Peptide PhaseFlow	Short-peptide 4×4 PSSI phase-diagram prediction and phase-conditioned sequence generation	Peptide tokenizer, shared Transformer, and Flow Matching stack
CondenGT / LLPS	Protein-level liquid-liquid phase-separation prediction	Full-protein sequence-context encoder and LLPS readout
DPR stack	Driving phase-separation region localization	Region-scoring head and post-processing state for DPR scanning

Download the checkpoint with:

hf download GENTEL-Lab/PhaseFlow PhaseFlow.pt --local-dir artifacts/models

Related resources

Resource	Link	Role
PhaseFlow code	github.com/GENTEL-lab/PhaseFlow	Installation, inference scripts, configs, and documentation
OpenPhase training data	GENTEL-Lab/OpenPhase	Public peptide, LLPS, and DPR research-data packages
Online demo	phaseflow.bio	Interactive PhaseFlow usage

Open access

The checkpoint and accompanying model card in this repository are fully open source and freely available to the community. We warmly welcome their use in research, benchmarking, method development, and reproducible studies. Please cite the relevant PhaseFlow work and retain appropriate source attribution when using or redistributing the weights.

Integrity

This repository contains metadata/file_inventory.csv. Verify all listed files before use; the inventory intentionally excludes itself to avoid a self-referential checksum.

import csv
import hashlib
from pathlib import Path

repo = Path(".")
with (repo / "metadata/file_inventory.csv").open(newline="") as handle:
    for item in csv.DictReader(handle):
        digest = hashlib.sha256((repo / item["path"]).read_bytes()).hexdigest()
        assert digest == item["sha256"], item["path"]

File	Description	SHA256
PhaseFlow.pt	Combined PhaseFlow runtime checkpoint (peptide, full-protein, and DPR weights)	7fb0091e6dd5a85bd3a6be7a0b606501700c4b8f28ff9b6e309267835a2fdff0

Responsible use

These weights are research resources, not clinical or diagnostic tools. Model predictions require independent validation and must be interpreted under the documented evidence and coordinate conventions in the PhaseFlow codebase.