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| license: cc-by-nc-4.0 |
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| # Ibis |
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| Ibis is a flow-matching model that generates conformational ensembles of proteins at Cα resolution from their amino acid sequence. It is the model studied in [Ablating Design Choices for Protein Ensemble Generators Across Structural Regimes](https://arxiv.org/abs/2611.05055) (Quinn & Bent, 2026). |
| ## Checkpoints |
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| | File | In the paper | Training data for disordered proteins | |
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| | `base/model.ckpt` | Base | CALVADOS coarse-grained simulations | |
| | `mix/model.ckpt` | Fragment 50% | half CALVADOS simulations, half IDRome-o fragment-assembled ensembles | |
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| Both models are also trained on AlphaFold DB structures of folded proteins and on CALVADOS simulations of multi-domain proteins. They take sequences of up to 510 residues. In the paper's evaluation against experimental data, `mix` agreed better with NMR chemical shifts and slightly worse with SAXS than `base`. |
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