DRMHB / examples /README.md
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DRMHB conversion and evaluation examples

Use Python 3.12 and vibframe-anndata==0.3.0. Run from the repository root. These examples explicitly request complete annotations; the package itself keeps ground-truth import disabled by default.

python -m pip install -r examples/requirements.txt
python examples/01_create_featureless_anndata.py data/DRMHB-compact.vibframe.zip derived/DRMHB-compact.v0.3.0.raw.h5ad
python examples/02_inspect_anndata.py derived/DRMHB-compact.v0.3.0.raw.h5ad --waveform-details
python examples/03_add_features.py derived/DRMHB-compact.v0.3.0.raw.h5ad derived/DRMHB-compact.v0.3.0.features.h5ad

01 — Import once

Accepts a ZIP or extracted VibFrame. The base is featureless: X has zero columns; raw waveforms, spectra, tachometers, identities and metadata remain available for later features. The default is float32, 8 MiB raw blocks, scope=all, strict missing truth and unchanged uncompressed raw HDF5 arrays.

--ground-truth-scope snapshot selects the legacy footprint; none (or --without-ground-truth) excludes evaluation labels. --max-sidecar-mib 512 limits original encoded sidecars, not total memory. --block-size-mib and --dtype are explicit. Existing destinations require --overwrite; inputs cannot be used as outputs.

No feature is computed from trends.parquet or from construction/diagnostic labels. The published dataset itself contains no scalar trends.

02 — Inspect without loading multi-GiB raw signals

The inspector uses h5py group metadata, small obs/var/package metadata and public ground-truth accessors. It never calls anndata.read_h5ad(backed="r") as a blanket out-of-core solution: that mode does not make all obsm/uns objects lazy. --waveform-details expands annotations only. --verify-hashes reads one original annotation file at a time and checks its SHA-256.

03 — Add the reference features

The thirteen feature requests remain the same as in the published EDA: velocity/acceleration RMS, subsynchronous/1X/low-harmonic bands, 1X/2X/BPFO/BPFI amplitudes, VPF-family RMS, and waveform RMS/crest factor/kurtosis.

For the current 2.6.0 fleet they materialized 468 machine/source-scoped columns. Each machine populates its relevant descriptors; structural NaNs are not zeros. The EDA constructs a common logical descriptor matrix without averaging different machines. Preserve var units, processing mode, point and algorithm/options when aligning columns. Do not match columns by short display name alone.

--block-rows 256 controls feature block size. --features-config FILE.yaml accepts an alternative package feature configuration. The original VibFrame is not reopened. Dimension counts and original-annotation manifest identities are compared before and after feature generation.

04 — Upgrade existing H5ADs

python examples/04_add_complete_ground_truth.py \
  derived/DRMHB-compact.v0.3.0.no-truth.h5ad data/DRMHB-compact.vibframe.zip \
  derived/DRMHB-compact.v0.3.0.enriched.h5ad

Uses add_ground_truth_to_h5ad. It preserves signals and features and creates a transactional disk copy. Supply the matching source set and retain obs.source, obs.machine and integer obs.snap_t. Roughly one extra H5AD of free disk is needed temporarily. Source-name/path collisions must not be repaired by guessing. Legacy capture-time companions are not populated retrospectively: reimport raw signals to obtain those arrays. Per-waveform crop offsets remain available from original and aligned waveform truth.

05 — Read originals and DiagGT

python examples/05_read_evaluation.py derived/DRMHB-compact.v0.3.0.features.h5ad
python examples/05_read_evaluation.py derived/DRMHB-compact.v0.3.0.features.h5ad \
  --path ground-truth/observations.parquet
python examples/05_read_evaluation.py derived/DRMHB-compact.v0.3.0.features.h5ad \
  --export derived/recovered-evaluation

Use the exact path from the printed inventory; the layout is not assumed. Use --source SOURCE_ID when a relative path occurs in several sources. read_evaluation_table() returns Arrow types; read_evaluation_json() returns parsed JSON; read_evaluation_file() returns the exact original bytes. Export refuses overwrites and retains dataset-wide originals, even for a sliced AnnData. No implicit DiagGT interval-to-snapshot labelling is performed.

Complete information and model input

obsm['ground_truth'] and obsm['waveform_ground_truth'] follow obs_names. The byte archive in uns['vibframe_evaluation'] is dataset-wide. snap_t is the snapshot key in integer microseconds UTC; raw capture t may include a crop offset. Waveform bindings include source/machine/point and supplied mode identity. Unknown sidecars/fields are retained instead of silently discarded.

For normality learning, fit scaling, missing-value rules and models only on calibration. Set thresholds on normal holdout. Evaluate on the future stream using timestamps. Faults, severities, OOD, nuisance and latent physical state are targets/audit fields, not automatic inputs. Declare explicitly any use of regime or RPM. Keep a separately generated controls dataset in a separate H5AD; controls are in data/DRMHB-compact-controls.vibframe.zip, separate from the current longitudinal ZIP. Use a distinct output basename for their H5AD.

Resources and verification

No raw compression settings or VibFrame bytes are changed. The current complete 0.3.0 base and feature H5ADs measure 8.169 and 8.265 GiB respectively; both retain 97 original files (26,874,052 bytes). Verify local derivatives with python tools/audit_dataset.py --deep. Metadata decoding also consumes RAM, so the raw block size and 512 MiB encoded-sidecar budget are not process-memory caps.

For a quick end-to-end check using the smaller controls ZIP:

python examples/01_create_featureless_anndata.py \
  data/DRMHB-compact-controls.vibframe.zip derived/DRMHB-compact-controls.v0.3.0.raw.h5ad
python examples/02_inspect_anndata.py \
  derived/DRMHB-compact-controls.v0.3.0.raw.h5ad --verify-hashes
python examples/03_add_features.py \
  derived/DRMHB-compact-controls.v0.3.0.raw.h5ad \
  derived/DRMHB-compact-controls.v0.3.0.features.h5ad
python examples/05_read_evaluation.py \
  derived/DRMHB-compact-controls.v0.3.0.features.h5ad

To exercise example 04, first create an H5AD with --without-ground-truth from that same controls ZIP, then pass it and the ZIP to example 04. These commands validate the conversion workflow without regenerating the campaign.

Package documentation: https://413hq.github.io/vibframe-anndata-docs/0.3.0/ Ground truth guide: https://413hq.github.io/vibframe-anndata-docs/0.3.0/guides/ground-truth/