BioRel/Llama-3.2_RelQA
Question Answering • Updated
id stringlengths 32 32 | messages listlengths 2 2 |
|---|---|
fb33eab1ad034c82bfc4a34894c60ec5 | [
{
"content": "Which genes have their expression decreased by the chemical (1-ethylpyrrolidin-2-yl) methyl)-4-hydroxy-7-methoxy-quinoline-3-carboxamide?",
"role": "user"
},
{
"content": "GATA3",
"role": "assistant"
}
] |
a6b420b1efbf4f27b39fbd5fa2ce436e | [
{
"content": "Which genes have their activity decreased by the chemical ((3,4-(methylenedioxy)benzyl)amino)-6-chloroquinazoline?",
"role": "user"
},
{
"content": "PDE5A",
"role": "assistant"
}
] |
f976ae6d494e4daa86b7825e7bd0c042 | [
{
"content": "Which genes are affected by the chemical ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine through binding interactions?",
"role": "user"
},
{
"content": "OPRM1",
"role": "assistant"
}
] |
71874462936a475a8c3b1bb619007f2d | [
{
"content": "Which genes are affected by the chemical ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine in relation to the response to substance interaction?",
"role": "user"
},
{
"content": "CYP2D6",
"role": "assistant"
}
] |
226978a211774bf1aedac024de763b79 | [
{
"content": "Which genes have their activity decreased by the chemical ((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)?",
"role": "user"
},
{
"content": "MET",
"role": "assistant"
}
] |
f325420f76f14b0894c891ef70c46cb6 | [
{
"content": "Which genes are affected by the chemical ((5Z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4-one) through binding interactions?",
"role": "user"
},
{
"content": "CLK3",
"role": "assistant"
}
] |
b5898aa2d0ab49ada3481a1cf3ffaa1b | [
{
"content": "Which genes have their activity decreased by the chemical ((5Z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4-one) according to the interaction data?",
"role": "user"
},
{
"content": "DYRK1A",
"role": "assistant"
}
] |
76ffd3fb169a4c328678d115a8bb80a7 | [
{
"content": "Which genes have their activity decreased by the chemical [(((E)-N-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)butyl)-3-phenylacrylamide]]?",
"role": "user"
},
{
"content": "DRD3",
"role": "assistant"
}
] |
c6c718d671404f8bb7db230d215d5576 | [
{
"content": "Which genes have their activity decreased by the chemical (Z)-1-thiophen-2-ylethylideneamino)thiourea?",
"role": "user"
},
{
"content": "CTSL",
"role": "assistant"
}
] |
c9e4c268048840199ac3e7ccbf90e6af | [
{
"content": "Which genes have their activity decreased by the chemical (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid?",
"role": "user"
},
{
"content": "GABBR1",
"role": "assistant"
}
] |
ebb0d5c2c7b44f37b72b40a5f6b7a1ea | [
{
"content": "Which genes are affected by the chemical compound (+)-JQ1 in terms of cleavage?",
"role": "user"
},
{
"content": "PARP1",
"role": "assistant"
}
] |
9ffe9b629e504196816eabc42bb1b45b | [
{
"content": "Which genes have their localization affected by the chemical compound (+)-JQ1?",
"role": "user"
},
{
"content": "RELA",
"role": "assistant"
}
] |
68b347240d3c4bafa6b1454a312bf3fc | [
{
"content": "Which genes have decreased acetylation due to the chemical (+)-JQ1 compound?",
"role": "user"
},
{
"content": "TP53",
"role": "assistant"
}
] |
c9a9140130154124aeef4f00aa9539b8 | [
{
"content": "Which genes have their response to the chemical (1'S, 2S)-4-amino-N-(1'-carbamoyl-2'-phenylethyl)-2-(4''-methyl-1''-naphthalenesulfonylamino)butanamide increased?",
"role": "user"
},
{
"content": "SSTR4",
"role": "assistant"
}
] |
e8bb593ac0cb4371b99a437834bfc693 | [
{
"content": "Which genes have their activity decreased by the chemical (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane?",
"role": "user"
},
{
"content": "TXNRD1",
"role": "assistant"
}
] |
3739fba44b29404ba67d3e38d990c5b2 | [
{
"content": "Which genes have their activity decreased by the chemical (1-(2-(bis(4-fluorophenyl)methoxy)ethyl)-4-(3-hydroxy-3-phenylpropyl) piperazinyl decanoate)?",
"role": "user"
},
{
"content": "SLC6A3",
"role": "assistant"
}
] |
d56a4870e9a8421fb3659077e9f3e74c | [
{
"content": "Which genes have their activity decreased by the chemical (1-hexyl-1H-indol-3-yl)-1-naphthalenylmethanone?",
"role": "user"
},
{
"content": "CYP1A1",
"role": "assistant"
}
] |
e457c07f928a49619564aa8956530767 | [
{
"content": "Which genes have their expression increased by the chemical (1-hydroxy-2-oxo-3-(N-methyl-3-aminopropyl)-3-methyl-3-aminopropyl)-3-methyl-1-triazene?",
"role": "user"
},
{
"content": "NFE2L2",
"role": "assistant"
}
] |
364ae2fbf34c4390909eb08f162ba510 | [
{
"content": "Which genes have their activity affected by the chemical (1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone?",
"role": "user"
},
{
"content": "CYP1A1",
"role": "assistant"
}
] |
a6a4f1eb74e04539bf2d2e2c9128f695 | [
{
"content": "Which genes have their activity increased by the chemical (1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one?",
"role": "user"
},
{
"content": "TFEB",
"role": "assistant"
}
] |
baf0a628bcab4412a1473a5f5a64f0be | [
{
"content": "Which genes have their localization affected by the chemical (1R,3S,3aR,8bS)-3a-(4-Bromophenyl)-6,8-dimethoxy-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta(b)benzofuran-1,8b-diol?",
"role": "user"
},
{
"content": "BAX",
"role": "assistant"
}
] |
8e249cc669574f019d995c86ed413d66 | [
{
"content": "Which genes have their activity increased by the chemical (1R,3S,3aR,8bS)-3a-(4-Bromophenyl)-6,8-dimethoxy-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta(b)benzofuran-1,8b-diol?",
"role": "user"
},
{
"content": "CASP3",
"role": "assistant"
}
] |
a064b100c3e6495db48d047a71fc39c6 | [
{
"content": "Which genes have increased cleavage interactions with the chemical (1R,3S,3aR,8bS)-3a-(4-Bromophenyl)-6,8-dimethoxy-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta(b)benzofuran-1,8b-diol?",
"role": "user"
},
{
"content": "PARP1",
"role": "assistant"
}
] |
7ce3106b789345a28bec7fefb66ba450 | [
{
"content": "Which genes are affected by the binding interaction with (1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8-azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester?",
"role": "user"
},
{
"content": "SLC6A3",
"role": "assistant"
}
] |
265fb512bef745a99f85eee5f32c3b86 | [
{
"content": "Which genes have their activity decreased by (1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8-azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester?",
"role": "user"
},
{
"content": "DAT",
"role": "assistant"
}
] |
a3f71d75e3424d4bbfc31e880ea5e8c4 | [
{
"content": "Which genes have their expression increased by the chemical (2)-5,6,7,8,4'-pentamethoxyflavanone?",
"role": "user"
},
{
"content": "BAX",
"role": "assistant"
}
] |
58057bd71b564d4e931060328ed7ed3c | [
{
"content": "Which genes have their activity increased by (2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate?",
"role": "user"
},
{
"content": "NR1I3",
"role": "assistant"
}
] |
d786193434bd4d9d8f676e92d7400045 | [
{
"content": "Which genes have their expression decreased by the chemical (2,4-dihydroxy-5-isopropylphenyl)-(5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl)methanone?",
"role": "user"
},
{
"content": "RNGTT",
"role": "assistant"
}
] |
d803527fd8984061ab892a76ceeddc73 | [
{
"content": "Which genes have their activity decreased by the chemical (2-(2',3'-dihydrobenzo(1,4)dioxin-6'-yl)-2-hydroxy-1-pyrrolidin-1-ylmethylethyl)nonanoic acid amide?",
"role": "user"
},
{
"content": "UGCG",
"role": "assistant"
}
] |
72c90d21f7e949e0b12bb20b3b2b0509 | [
{
"content": "Which genes have their activity affected by (2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane?",
"role": "user"
},
{
"content": "HTR1A",
"role": "assistant"
}
] |
a687bcf539aa48669308691dda15a435 | [
{
"content": "Which genes have their binding affected by the chemical (2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane?",
"role": "user"
},
{
"content": "ADRA1A",
"role": "assistant"
}
] |
7dc544e494f445f998156712d60ae60a | [
{
"content": "Which genes have their activity decreased by the chemical (2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane?",
"role": "user"
},
{
"content": "ADRA2A",
"role": "assistant"
}
] |
3170de95dd6b432898ad8994d0f57ea7 | [
{
"content": "Which genes have their activity decreased by the chemical (2-(6-fluoro-1H-indol-3-yl)-ethyl)-(3-(2,2,3,3-tetrafluoropropoxy)benzyl)amine?",
"role": "user"
},
{
"content": "HTR6",
"role": "assistant"
}
] |
719b5de6d84d45fdaabfacbd86425072 | [
{
"content": "Which genes have their activity affected by (2-(trimethylammonium)ethyl)methanethiosulfonate?",
"role": "user"
},
{
"content": "CFTR",
"role": "assistant"
}
] |
a52b3dd585ab448aa316194493087491 | [
{
"content": "Which genes have their activity decreased by the chemical (2-(trimethylammonium)ethyl)methanethiosulfonate?",
"role": "user"
},
{
"content": "SLC12A2",
"role": "assistant"
}
] |
44a589b684114ac58b77fba5b3159f81 | [
{
"content": "Which genes have their binding affected by the chemical (2-boronoethyl)-cysteine?",
"role": "user"
},
{
"content": "ARG2",
"role": "assistant"
}
] |
5770eae647cf42f69e2acc11f49f65db | [
{
"content": "Which genes have their activity decreased by the chemical (2-boronoethyl)-cysteine?",
"role": "user"
},
{
"content": "ARG1",
"role": "assistant"
}
] |
3260d0e5c443430495aa4bbcc93b46c0 | [
{
"content": "Which genes have their activity increased by (2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide?",
"role": "user"
},
{
"content": "NFE2L2",
"role": "assistant"
}
] |
0b783fe1ee5641bd98b4fe89c902fcee | [
{
"content": "Which genes have their activity decreased by the chemical (2-hydroxy-4-(octyloxy)phenyl)phenylmethanone?",
"role": "user"
},
{
"content": "HSD3B1",
"role": "assistant"
}
] |
74142691539a4055967bb20be5a6ca11 | [
{
"content": "Which genes have their activity decreased by (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide according to the interaction data?",
"role": "user"
},
{
"content": "KCNA5",
"role": "assistant"
}
] |
034d41b2785b44118b99829c9758a22a | [
{
"content": "Which genes have their uptake decreased by the chemical (22R, 25R)-20alpha-spirost-5-en-3beta-yl hexanoate?",
"role": "user"
},
{
"content": "APP",
"role": "assistant"
}
] |
fce023cb648b4d2da5c71286bbb8012b | [
{
"content": "Which genes have their expression increased by the chemical (2E)-N,N-dibutyl-3-(4-hydroxy-3-methoxyphenyl)acrylamide?",
"role": "user"
},
{
"content": "CDKN1A",
"role": "assistant"
}
] |
30e5c9c9888648ce9506a290f5fc9d32 | [
{
"content": "Which genes are affected by the chemical (2E)-decenal through reduction?",
"role": "user"
},
{
"content": "AKR1B1",
"role": "assistant"
}
] |
01e7baaeb5b04e29b254e993cb032de2 | [
{
"content": "Which genes have their phosphorylation decreased by (2E,4E,6E,10E)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid?",
"role": "user"
},
{
"content": "NFKBIA",
"role": "assistant"
}
] |
620163948f07429eb518b4ccd0eda24d | [
{
"content": "Which genes have their activity decreased by the chemical (2R, 3S)-2-(((4-(2-butynyloxy)phenyl)sulfonyl)amino)-N,3-dihydroxybutanamide?",
"role": "user"
},
{
"content": "ADAM17",
"role": "assistant"
}
] |
1b294af87aeb4e739c45967b2f5a8372 | [
{
"content": "Which genes have their activity decreased by the chemical (2S)-2-(4-(((3S)-1-acetimidoyl-3-pyrrolidinyl)oxy)phenyl)-3-(7-amidino-2-naphtyl)propanoic acid?",
"role": "user"
},
{
"content": "F10",
"role": "assistant"
}
] |
92b6949a33af4b79aa7bd7ed831acfa8 | [
{
"content": "Which genes have their activity increased by the chemical (3,3-dibenzylimidazo(1,2-a)pyridin-2-(3H)-one)?",
"role": "user"
},
{
"content": "CHAT",
"role": "assistant"
}
] |
9cb9c81ac7214e6d8e1d9ee3bd7d3040 | [
{
"content": "Which genes have their activity increased by the chemical (3,4,5-trimethoxy-N-(2-methoxyethyl)-N-(4-phenyl-2-thiazolyl)benzamide?",
"role": "user"
},
{
"content": "ANO1",
"role": "assistant"
}
] |
c073535a2dfe471f9e20bef04e8ece1f | [
{
"content": "Which genes have their activity decreased by the chemical (3,6-dimethyl-2-(2,4,6-trimethylphenoxy)pyridin-4-yl)(1-ethylpropyl)amine according to the interaction data?",
"role": "user"
},
{
"content": "CRHR1",
"role": "assistant"
}
] |
ddd5b963d0004365aeda531cf7c091a7 | [
{
"content": "Which genes have their expression affected by the chemical (3-(4-(bis(2-chloroethyl)amino)phenyl)-3-propyl)carbamic acid 2-(6-(17-hydroxy-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-11-yl)hexylamino)ethyl ester?",
"role": "user"
},
{
"content"... |
d8ffa0b9a98743b296e35a94e783bbda | [
{
"content": "Which genes have their expression decreased by the chemical (3-(4-(bis(2-chloroethyl)amino)phenyl)-3-propyl)carbamic acid 2-(6-(17-hydroxy-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-11-yl)hexylamino)ethyl ester?",
"role": "user"
},
{
"content... |
62947515cda44ee4be2355b4f1492c84 | [
{
"content": "Which genes have their cleavage increased by the chemical (3-(4-(bis(2-chloroethyl)amino)phenyl)-3-propyl)carbamic acid 2-(6-(17-hydroxy-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-11-yl)hexylamino)ethyl ester?",
"role": "user"
},
{
"content":... |
ff176744acaa4db494dcb4bc78d76f40 | [
{
"content": "Which genes have their expression increased by the chemical (3-(4-(bis(2-chloroethyl)amino)phenyl)-3-propyl)carbamic acid 2-(6-(17-hydroxy-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-11-yl)hexylamino)ethyl ester?",
"role": "user"
},
{
"content... |
2cc0ff4d89de468ca9dcb6ba2761a101 | [
{
"content": "Which genes have their response to the substance decreased by (3-aminopropyl)(n-butyl)phosphinic acid?",
"role": "user"
},
{
"content": "HOMER1",
"role": "assistant"
}
] |
9eb1161532b8486b9721ab4571a9466b | [
{
"content": "Which genes have their activity decreased by the chemical (3-chloro-4-fluoro-phenyl)-(6-(4-diethylaminomethyl-piperidin-1yl)-pyrimido(5,4-d)pyrimidin-4-yl)amine according to the interaction data?",
"role": "user"
},
{
"content": "EGFR",
"role": "assistant"
}
] |
546c1291aba54c5d8f5ce8e7c905f502 | [
{
"content": "Which genes have their activity decreased by (3-ethyl-2-methyl-quinolin-6-yl)-(4-methoxycyclohexyl)methanone methanesulfonate?",
"role": "user"
},
{
"content": "GRM1",
"role": "assistant"
}
] |
50ea5b7e73044ba4ae999acc0a41f424 | [
{
"content": "Which genes have their activity decreased by (3-exo)-8-benzoyl-N-(((2S)7-chloro-2,3-dihydro-1,4-benzodioxin-1-yl)methyl)-8-azabicyclo(3.2.1)octane-3-methanamine monohydrochloride?",
"role": "user"
},
{
"content": "DRD2",
"role": "assistant"
}
] |
57978db55dba4427874d25afed224e93 | [
{
"content": "Which genes have their activity increased by the chemical (3-exo)-8-benzoyl-N-(((2S)7-chloro-2,3-dihydro-1,4-benzodioxin-1-yl)methyl)-8-azabicyclo(3.2.1)octane-3-methanamine monohydrochloride?",
"role": "user"
},
{
"content": "HTR1A",
"role": "assistant"
}
] |
9478ab6e85d24e5c9afd7af1f4ee7c9b | [
{
"content": "Which genes have their activity affected by the chemical (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone?",
"role": "user"
},
{
"content": "ABCG2",
"role": "assistant"
}
] |
7d465b908ec04df792672ed6b6aa7ebc | [
{
"content": "Which genes are affected by the binding interaction of (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone?",
"role": "user"
},
{
"content": "CNR2",
"role": "assistant"
}
] |
72230064060b40818033a5a160dea48b | [
{
"content": "Which genes have their phosphorylation decreased by the chemical (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone?",
"role": "user"
},
{
"content": "NFKBIA",
"role": "assistant"
}
] |
2aeb40bba7804817a9aabbed6bd12987 | [
{
"content": "Which genes have their response to the chemical (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone decreased?",
"role": "user"
},
{
"content": "ADORA2A",
"role": "assistant"
}
] |
3ae2ad89c7064d39890b45940921e73d | [
{
"content": "Which genes have their localization increased by the chemical (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone?",
"role": "user"
},
{
"content": "NFATC4",
"role": "assistant"
}
] |
7941a0a7e57f41deb55defb72cd75c37 | [
{
"content": "Which genes have their activity decreased by the chemical (3b,5b,7a,12a)-7,12-dihydroxy-3-(2-((4-((11b,17b)-17-hydroxy-3-oxo-17-prop-1-ynylestra-4,9-dien-11-yl) phenyl)(methyl)amino)ethoxy)cholan-24-oic acid?",
"role": "user"
},
{
"content": "NR3C1",
"role": "assistant"
}
] |
be27acc218064a98b6ca56d0c4f1e5a6 | [
{
"content": "Which genes have their cleavage increased by the chemical (4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid?",
"role": "user"
},
{
"content": "PARP1",
"role": "assistant"
}
] |
9fd49f1c15554879bd95cecc2b2f806b | [
{
"content": "Which genes are affected by the binding interaction with (4-((1-(3-fluorophenyl)methyl)-1H-indazol-5-ylamino)-5-methylpyrrolo(2,1-f)(1,2,4)triazin-6-yl)carbamic acid 3-morpholinylmethyl ester?",
"role": "user"
},
{
"content": "CD274",
"role": "assistant"
}
] |
58c3d684f13644dabcb3abcd7c9f7652 | [
{
"content": "Which genes have their activity decreased by the chemical (4-(5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl)pyridin-2-yl)-(1-phenylethyl)amine according to the interaction data?",
"role": "user"
},
{
"content": "MAPK14",
"role": "assistant"
}
] |
8ea3287c6c4146d7b06a3f586f9f3cf4 | [
{
"content": "Which genes have their activity increased by the chemical (4-benzylpiperazin-1-yl)acetic acid (3-allyl-2-hydroxybenzylidene)hydrazine?",
"role": "user"
},
{
"content": "CASP3",
"role": "assistant"
}
] |
7a4d07ed57c844d5b256160a339f4c36 | [
{
"content": "Which genes are affected by the binding interaction with (4-chloro-2-((2-fluoro-5-(propylsulfonyl)phenyl)ethynyl)phenoxy)acetic acid?",
"role": "user"
},
{
"content": "PTGDR2",
"role": "assistant"
}
] |
f5a5b01fb24d4bc4958d4042fe627db6 | [
{
"content": "Which genes are affected by the binding interaction of (4-chloro-2-((2-methyl-5-(propylsulfonyl)phenyl)ethynyl)phenoxy)acetic acid?",
"role": "user"
},
{
"content": "PTGDR2",
"role": "assistant"
}
] |
d6b21c7fe8b546128394882ec4b2826a | [
{
"content": "Which genes have their activity decreased by (4-chloro-2-((2-methyl-5-(propylsulfonyl)phenyl)ethynyl)phenoxy)acetic acid?",
"role": "user"
},
{
"content": "PTGDR",
"role": "assistant"
}
] |
337905963c9f4c08a3392b53de5812b5 | [
{
"content": "Which genes have their localization affected by the chemical (4-methyl-1-naphthyl)-(1-pentylindol-3-yl)methanone?",
"role": "user"
},
{
"content": "BCL2",
"role": "assistant"
}
] |
1d19b694528d4e65a18812a8c15ef402 | [
{
"content": "Which genes have their activity increased by the chemical (4S,5S)-4,5-dihydroxy-1,2-dithiane?",
"role": "user"
},
{
"content": "CYP2A5",
"role": "assistant"
}
] |
28c85a4271454dd18bb4bb0285f7f15a | [
{
"content": "Which genes have increased cleavage interactions with the chemical (4S,5S)-4,5-dihydroxy-1,2-dithiane?",
"role": "user"
},
{
"content": "CASP3",
"role": "assistant"
}
] |
5fb92fbf3b3a43d0aac73ba53ec70482 | [
{
"content": "Which genes have their activity decreased by the chemical (5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid?",
"role": "user"
},
{
"content": "DGAT1",
"role": "assistant"
}
] |
be1ccbea14c44dc7aab18999296ff469 | [
{
"content": "Which genes have their activity increased by the chemical (5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid?",
"role": "user"
},
{
"content": "GPT",
"role": "assistant"
}
] |
ceb9e51300224a128a381c6fcba43b14 | [
{
"content": "Which genes have their activity decreased by the chemical (5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol?",
"role": "user"
},
{
"content": "MTOR",
"role": "assistant"
}
] |
17057ce1a7cf476aa8b22d3127fbc4d8 | [
{
"content": "Which genes have their activity decreased by the chemical (5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid according to the interaction data?",
"role": "user"
},
{
"content": "SCD1",
"role": "assistant"
}
] |
055788828d6d4c0e9098abb93ba61b34 | [
{
"content": "Which genes have their expression decreased by (5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride?",
"role": "user"
},
{
"content": "CTNNB1",
"role": "assistant"
}
] |
f6ac764b52d94e24a5484b1b83e59d00 | [
{
"content": "Which genes have increased phosphorylation due to the chemical (5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride?",
"role": "user"
},
{
"content": "VASP",
"role": "assistant"
}
] |
ddebfafcf3b94fdaa0838d2531279b9d | [
{
"content": "Which genes have their expression increased by (6,7-dimethoxyquinolin-4-yl)(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)methyl acetate?",
"role": "user"
},
{
"content": "CASP3",
"role": "assistant"
}
] |
6b08ade4946d43cfac9977566cd6273d | [
{
"content": "Which genes have their activity decreased by the chemical (7-(2-(4-difluorophenyl)-1-piperazinyl)ethyl)-2-(2-furanyl)-7H-pyrazolo(4,3-e)(1,2,4)triazolo(1,5-c)pyrimidin-5-amine?",
"role": "user"
},
{
"content": "ADORA2A",
"role": "assistant"
}
] |
6d2ef44f12f6448fbc457ddeebee204f | [
{
"content": "Which genes have their activity increased by the chemical (Cr(salprn)(H2O)2)ClO4?",
"role": "user"
},
{
"content": "CASP3",
"role": "assistant"
}
] |
6f36cb810b3141cda7099c9204709b20 | [
{
"content": "Which genes have their expression decreased by the chemical (E)-2-((2-(benzo(d)thiazol-2-yl)hydrazono)methyl)-4-nitrophenol?",
"role": "user"
},
{
"content": "MYC",
"role": "assistant"
}
] |
116e19a474714442997a3400bf5c8b08 | [
{
"content": "Which genes are affected by the chemical (E)-3-((((6-(2-carboxyethenyl)-5-((8-(4-methoxyphenyl)octyl)oxy)-2-pyridinyl)methyl)thio)methyl)benzoic acid through binding interactions?",
"role": "user"
},
{
"content": "CYSLTR1",
"role": "assistant"
}
] |
0a07be67d9c14ed3a4178078ebb27a09 | [
{
"content": "Which genes have their activity decreased by the chemical (E)-3-((((6-(2-carboxyethenyl)-5-((8-(4-methoxyphenyl)octyl)oxy)-2-pyridinyl)methyl)thio)methyl)benzoic acid according to the interaction data?",
"role": "user"
},
{
"content": "ALOX5",
"role": "assistant"
}
] |
f54934934a7e449e9b67c80a895ec73b | [
{
"content": "Which genes have their oxidation increased by the chemical N1-acetylisoniazid?",
"role": "user"
},
{
"content": "MPO",
"role": "assistant"
}
] |
61f7e7ae8d694a3187fadabc810a8eb1 | [
{
"content": "Which genes have their activity decreased by the chemical (N-(1-(((cyanoimino)(5-quinolinylamino)methyl)amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide)?",
"role": "user"
},
{
"content": "P2RX7",
"role": "assistant"
}
] |
62b02869f0a7481db8b5fbef2bb929d9 | [
{
"content": "Which genes have their transport increased by (N-5-(4-nitrobenzofurazan-7-yl)lysyl(8))cyclosporine?",
"role": "user"
},
{
"content": "ABCB1",
"role": "assistant"
}
] |
10ddbf3c568244008b04a3a62a627cad | [
{
"content": "Which genes have their activity decreased by the chemical (N-N'-bis-(2-(1H-indol-3-yl)-ethyl)-N,N'-bis-(3-thiomorpholin-4-yl-propyl)-phthalamide)?",
"role": "user"
},
{
"content": "TACR2",
"role": "assistant"
}
] |
10e7d12b392148fb8e6bb3fc4bb32d08 | [
{
"content": "Which genes have their activity decreased by the chemical (Nphe(1),Arg(14),Lys(15))N-OFQ NH(2)?",
"role": "user"
},
{
"content": "OPRL1",
"role": "assistant"
}
] |
6600bf98b8134cf9aea9c6e5c86531aa | [
{
"content": "Which genes have their activity increased by the chemical (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide?",
"role": "user"
},
{
"content": "KCNQ1",
"role": "assistant"
}
] |
ff3c309f17b74bed9ab8056d8b82f8db | [
{
"content": "Which genes have their activity decreased by the chemical [(R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine]?",
"role": "user"
},
{
"content": "TRPM7",
"role": "assistant"
}
] |
4ce19ad6e5e1465b805eea915f4aa44f | [
{
"content": "Which genes have their activity increased by the chemical (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine?",
"role": "user"
},
{
"content": "PLG",
"role": "assistant"
}
] |
cc16954751e24e33b660970d063ce529 | [
{
"content": "Which genes have their activity decreased by the chemical (R)-N-cycloheptyl-6-((((tetrahydro-2-furyl)methyl)amino)methyl)thieno(2,3-d)pyrimidin-4-ylamine?",
"role": "user"
},
{
"content": "GRM1",
"role": "assistant"
}
] |
e350fdc82a70417cba544b3fd130e5cb | [
{
"content": "Which genes have their response to the chemical (S)-2-methylbutyronitrile increased?",
"role": "user"
},
{
"content": "CYP2E1",
"role": "assistant"
}
] |
c5b20db932f0432da577485cd31a33d3 | [
{
"content": "Which genes have their expression decreased by (arginine)9-cysteinyl-glutaminyl-cysteinyl-arginyl-arginyl-lysyl-asparagine?",
"role": "user"
},
{
"content": "MYC",
"role": "assistant"
}
] |
6a89ceed199e47d1908bcd04e937e1ed | [
{
"content": "Which genes have their activity increased by (dichloro)tetraammineruthenium(III)?",
"role": "user"
},
{
"content": "CASP3",
"role": "assistant"
}
] |
60edae4a3cfb46fdaa6f3a1afee0fea7 | [
{
"content": "Which genes have their activity increased by the chemical (endo-N-8-methyl-8-azabicyclo(3.2.1)oct-3-yl)-2,3-dihydro-3-ethyl-2-oxo-1H-benzimidazol-1-carboxamide?",
"role": "user"
},
{
"content": "HTR4",
"role": "assistant"
}
] |
4efa4ee9b60a4f9fadd7eaff8462615c | [
{
"content": "Which genes have their expression increased by the chemical (gamma-CyD)2 C60?",
"role": "user"
},
{
"content": "CDKN1A",
"role": "assistant"
}
] |
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Dataset Summary
BioRel-CTD-Relational-QA is a biomedical relational question–answering dataset created by transforming curated relationships from the Comparative Toxicogenomics Database (CTD) into natural-language Q&A pairs. The question–answer formatting was generated with the assistance of the gpt-4o-mini model, while all underlying relational facts originate from CTD.
Any dataset derived from CTD that is distributed with or alongside this work is Research use only, derived from CTD, subject to CTD terms (non-commercial). In accordance with the CTD data-use terms (https://ctdbase.org/about/legal.jsp):
This work uses and cites CTD (https://ctdbase.org), the source database.
Contexts that use CTD-derived data link back to the applicable CTD data pages at https://ctdbase.org.
- CTD may access this dataset for quality control purposes.
- Commercial use is prohibited without the prior express written permission of then MDI Biological Laboratory and NC State University.
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