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metadata 
pretty_name: VCDesign-CED processed inputs and frozen evaluation artifacts
tags:
  - single-cell
  - perturb-seq
  - intervention-design

VCDesign-CED processed data

This repository stores the frozen processed inputs used by the VCDesign-CED paper, plus the selected base-model checkpoint and compact evaluation records. The source single-cell H5AD files are obtained from the original public releases and are not duplicated here.

Contents

Directory Contents
inputs/ The 19 frozen inputs referenced by the paper's training configuration, plus source-goal metadata
inputs/four_context/packs/ K562, RPE1, HepG2 and Jurkat processed context packs
inputs/external_baselines/scores/ Frozen external-comparator score matrices for RPE1, HepG2 and Jurkat
checkpoints/ Selected epoch-8 VCDesign-CED base-model checkpoint
records/ Training, selection, evaluation, context-build and comparator verification records
code/ Versioned, anonymous code-package ZIP for local download and review
DATA_MANIFEST.json File sizes, release SHA-256 values and original SHA-256 values where a record was anonymized

Code package

Download the latest verified code package directly:

VCDesign_ICLR2027_code_v0.2.0.zip

SHA-256: 78c96552727b378ecde418bac9e4f9015739c5e49e4aeac7b57a345c220c40ab

Version 0.2.0 places gene_open_inverse/ directly at the package root and adds an anonymous, visual README with a complete local copy of Figure 1. The ZIP also contains the frozen configuration, exact CPU verification dependencies, a synthetic demo, 162 protocol tests, and its own per-file CODE_PACKAGE_MANIFEST.sha256. It does not contain large processed inputs, checkpoints, Git history, or author-account links.

Previous release: v0.1.0

DATA_MANIFEST.json identifies the exact bytes uploaded. JSON records that contained compute-host paths have only those path strings replaced with release relative paths or UNBUNDLED/<filename> labels. The original file hash is retained beside each transformed record's release hash. Numeric arrays and model weights are copied byte-for-byte and checked against the frozen run manifest.

The processed data correspond to the code package's configs/paper_run_v1.json path layout. To place only the data files in a checkout of that package without replacing its README:

hf download Boom5426/VCDesign --repo-type dataset \
  --include 'inputs/**' 'checkpoints/**' 'records/**' 'DATA_MANIFEST.json' \
  --local-dir /path/to/code-package
python3 tools/verify_processed_data.py --root /path/to/code-package

The exact repository revision should be pinned for a reproduction run. The selected checkpoint was epoch 8, with frozen SHA-256 58da13d252faf9bcaa74c53345c0afc380882bdd5f410a77cfa5044f9a6e9484.

Original public sources

The derived files are tied to those source versions; the K562 genome-scale screen is distinct from the K562 essential screen. Cite the original data and knowledge resources when using this collection.