Add dataset card for RipplePLM
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by nielsr HF Staff - opened
README.md
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---
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task_categories:
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- text-generation
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tags:
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- biology
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- protein
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- mutation
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---
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# RipplePLM Dataset
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This dataset accompanies the paper [RipplePLM: Structural and Property Decoupling for Protein Mutation Effect Generation](https://huggingface.co/papers/2610.01891). It contains protein mutation data for training and evaluating models that generate natural-language descriptions of protein mutation effects.
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Code and usage instructions are available at [https://github.com/Lyu6PosHao/RipplePLM](https://github.com/Lyu6PosHao/RipplePLM).
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The dataset is organized into two splits (`structural_split/` and `temporal_split/`), each containing `train_with_label.csv`, `val_with_label.csv`, and `test_with_label.csv`.
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The columns include:
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- `entry`: Protein ID and mutation, e.g. `P12345-A123B`; residue positions are 1-based.
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- `protein1`: Wild-type amino acid sequence.
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- `protein2`: Mutant sequence; reconstructed from `entry` if absent.
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- `function`: Wild-type protein function used as input context.
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- `uniprot_description`: UniProt mutation-effect description.
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- `GPT_description`: Additional generated mutation-effect description.
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- `all_description`: Description field used to filter samples with missing annotations.
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- `ephod_label`: Integer class label for pH.
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- `pptstab_label`: Integer class label for thermostability.
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The reference text combines `uniprot_description` and `GPT_description`. Samples missing `function` or `all_description` are omitted.
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