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medium_convergence_02305 | PEX12 and PEX13 both interact with a specific peroxin. Evidence regarding this entity states: 'In addition, we extend the list of peroxins with which human Pex19p interacts to include the PMP Pex16p and show that Pex19p's CaaX prenylation motif is an important determinant in the affinity of Pex19p for Pex10p, Pex11pbet... | Zellweger spectrum disorders | Medium | convergence | {"qa_id":"medium_convergence_02305","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PEX12 and PEX13 both interact with a specific peroxin. Evidence regarding this entity states: 'In addition, we extend the list of peroxins with which human P... | |
medium_convergence_02307 | Vaccinia virus and Human alphaherpesvirus 1 both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -2.22 and an adjusted p-value of 0.007178. Which cellular component is this gene located in? | extracellular matrix | Medium | convergence | {"qa_id":"medium_convergence_02307","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human alphaherpesvirus 1 both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study ... | |
medium_convergence_02308 | ANAPC11 and CDC20 both interact with a shared protein. Experimental evidence indicates that in extracts from M phase HeLa cells, p55CDC coimmunoprecipitates with this shared protein, along with Cdc16 and Mad2, as part of the M phase checkpoint machinery. Which protein is encoded by this shared entity? | Cell division cycle protein 27 homolog | Medium | convergence | {"qa_id":"medium_convergence_02308","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC11 and CDC20 both interact with a shared protein. Experimental evidence indicates that in extracts from M phase HeLa cells, p55CDC coimmunoprecipitates ... | |
medium_convergence_02309 | Both Orthohepevirus A and Primate bocaparvovirus 1 are associated with the downregulation of a specific gene. Experimental data for this gene in hepatocytes (from study GSE135619) reports a log2 fold change of -2.136 and an adjusted p-value of 0.04032. Which protein is encoded by this gene? | CKLF-like MARVEL transmembrane domain-containing protein 8 | Medium | convergence | {"qa_id":"medium_convergence_02309","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Primate bocaparvovirus 1 are associated with the downregulation of a specific gene. Experimental data for this gene in hepatocytes ... | |
medium_convergence_02310 | LAMTOR2 and ATP6V0C each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'In a two-hybrid screen with p14 as a bait, we identified the mitogen-activated protein kinase (MAPK) scaffolding protein MAPK/extracellular signal-regulated kinase (ERK) kinase (MEK) pa... | Ragulator complex protein LAMTOR3 | Medium | convergence | {"qa_id":"medium_convergence_02310","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LAMTOR2 and ATP6V0C each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'In a two-hybrid screen... | |
medium_convergence_02311 | BMP7 and BMPR1B both interact with a common protein. Evidence indicates this shared entity is a transmembrane serine/threonine kinase that binds BMP-2 and BMP-7 in association with multiple type I receptors, including BMPR-IA/Brk1, BMPR-IB, and ActR-I. Which disease is associated with this entity via a biomarker relati... | anemia due to chronic disorder | Medium | convergence | {"qa_id":"medium_convergence_02311","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMP7 and BMPR1B both interact with a common protein. Evidence indicates this shared entity is a transmembrane serine/threonine kinase that binds BMP-2 and BM... | |
medium_convergence_02312 | STUB1 and DNAJA1 both interact with a shared protein. Evidence regarding this shared entity states: 'In addition, CHIP interacted directly with Csp, which was confirmed by in vitro binding experiments.' Which protein is encoded by this shared entity? | DnaJ homolog subfamily C member 5 | Medium | convergence | {"qa_id":"medium_convergence_02312","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and DNAJA1 both interact with a shared protein. Evidence regarding this shared entity states: 'In addition, CHIP interacted directly with Csp, which wa... | |
medium_convergence_02313 | EIF3B and EIF3F both interact with a shared protein. Evidence indicates that activating mTOR signaling with insulin increases the amount of this protein bound to eIF3 by as much as five-fold. Which disease is associated with this protein as a biomarker? | myocardial ischemia | Medium | convergence | {"qa_id":"medium_convergence_02313","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3B and EIF3F both interact with a shared protein. Evidence indicates that activating mTOR signaling with insulin increases the amount of this protein boun... | |
medium_convergence_02314 | COPS5 and BNIPL each interact with more than one shared protein. Evidence concerning one such shared entity states: 'Here we identified that JAB1 (Jun activation domain-binding protein 1), a co-activator of AP-1, which is essential for liver regeneration, specifically interacts with intracellular HPO.' Which protein is... | FAD-linked sulfhydryl oxidase ALR | Medium | convergence | {"qa_id":"medium_convergence_02314","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS5 and BNIPL each interact with more than one shared protein. Evidence concerning one such shared entity states: 'Here we identified that JAB1 (Jun activa... | |
medium_convergence_02315 | Human polyomavirus 1 and Human immunodeficiency virus 1 both upregulate a specific gene. Evidence for this gene in renal epithelial cells (study GSE135833) reports a log2 fold change of approximately 6.11 and an adjusted p-value of 0.0138. Which disease is associated with this gene? | Marshall-Smith syndrome | Medium | convergence | {"qa_id":"medium_convergence_02315","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Human immunodeficiency virus 1 both upregulate a specific gene. Evidence for this gene in renal epithelial cells (study GSE135833) r... | |
medium_convergence_02316 | NPLOC4 and VCP both interact with a shared protein. Evidence indicates that the ubiquitin-like domain of this shared protein recruits p97, enabling the extraction of client transmembrane domains into the cytosol. Which cell type is enriched for this shared protein? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_02316","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NPLOC4 and VCP both interact with a shared protein. Evidence indicates that the ubiquitin-like domain of this shared protein recruits p97, enabling the extra... | |
medium_convergence_02317 | Human alphaherpesvirus 1 and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately -1.007 and an adjusted p-value of 0.002075. Which cellular component is this gene located in? | cytosol | Medium | convergence | {"qa_id":"medium_convergence_02317","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE1149... | |
medium_convergence_02318 | JAG2 and MAML1 both interact with a specific protein. Experimental evidence indicates that three DSL proteins bind to endogenous levels of this protein on the surface of BaF3 cells, although the binding characteristics of Jagged2 to this protein differ from those of Delta1 and Jagged1. Which protein is encoded by the g... | Neurogenic locus notch homolog protein 2 | Medium | convergence | {"qa_id":"medium_convergence_02318","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"JAG2 and MAML1 both interact with a specific protein. Experimental evidence indicates that three DSL proteins bind to endogenous levels of this protein on th... | |
medium_convergence_02319 | RPA1 and TP53 share a common interacting partner. Evidence indicates that this partner phosphorylates human p53 at Thr18 and disrupts the p53-Mdm2 interaction in vitro, although a significant decrease in p53 ubiquitination by Mdm2 in vivo was not detected. Which disease is associated with this entity through genomic al... | pontocerebellar hypoplasia type 1 | Medium | convergence | {"qa_id":"medium_convergence_02319","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RPA1 and TP53 share a common interacting partner. Evidence indicates that this partner phosphorylates human p53 at Thr18 and disrupts the p53-Mdm2 interactio... | |
medium_convergence_02320 | Human alphaherpesvirus 1 and Primate bocaparvovirus 1 each downregulate more than one shared gene. Evidence concerning one such shared entity reports a log2 fold change of -1.090 and an adjusted p-value of 0.002083. Which cellular component is that entity located in? | mitochondrion | Medium | convergence | {"qa_id":"medium_convergence_02320","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Primate bocaparvovirus 1 each downregulate more than one shared gene. Evidence concerning one such shared entity reports a log2 ... | |
medium_convergence_02321 | ZNF263 and EHMT2 share common interaction partners. One such shared partner is reported to directly bind G9a both in vivo and in vitro and to colocalize with it in the nucleus during DNA replication. Which protein is encoded by this shared partner? | DNA (cytosine-5)-methyltransferase 1 | Medium | convergence | {"qa_id":"medium_convergence_02321","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ZNF263 and EHMT2 share common interaction partners. One such shared partner is reported to directly bind G9a both in vivo and in vitro and to colocalize with... | |
medium_convergence_02322 | CTNNA1 and MYC share multiple interacting partners. One of these shared partners is described by the evidence: 'The 326-509 internal domain was found to bind this protein.' Which cell type is this specific shared partner enriched in? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_02322","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNA1 and MYC share multiple interacting partners. One of these shared partners is described by the evidence: 'The 326-509 internal domain was found to bind... | |
medium_convergence_02323 | EGFR and MAPK1 both interact with a specific shared protein. Experimental evidence indicates that ERK1 and ERK2 were detected in immunoprecipitates of RSK3 (and to a lesser extent, a related kinase), but were absent in RSK1 immunoprecipitates. Which protein is encoded by the gene corresponding to this shared entity? | Ribosomal protein S6 kinase alpha-3 | Medium | convergence | {"qa_id":"medium_convergence_02323","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and MAPK1 both interact with a specific shared protein. Experimental evidence indicates that ERK1 and ERK2 were detected in immunoprecipitates of RSK3 (... | |
medium_convergence_02324 | Both Measles morbillivirus and Influenza A virus are known to downregulate a specific shared gene. Experimental data for this gene reports a log2 fold change of approximately -1.04 and an adjusted p-value of 0.0311. Which protein does this gene product interact with? | MMGT1 | Medium | convergence | {"qa_id":"medium_convergence_02324","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Influenza A virus are known to downregulate a specific shared gene. Experimental data for this gene reports a log2 fold change... | |
medium_convergence_02325 | HIF1A and MYC share multiple interacting partners. One such shared partner has been experimentally shown to interact specifically with two subdomains of HIF-1alpha. Which protein is encoded by this shared partner? | Proteasome subunit alpha type-7 | Medium | convergence | {"qa_id":"medium_convergence_02325","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HIF1A and MYC share multiple interacting partners. One such shared partner has been experimentally shown to interact specifically with two subdomains of HIF-... | |
medium_convergence_02326 | AFF1 and PML both interact with a shared protein entity. Evidence indicates that SIAH-1/2 binds to and targets this entity for proteasome-mediated degradation, resulting in the loss of its transcriptional co-activating properties and a reduction in the number of endogenous nuclear bodies associated with it. Which disea... | cerebral infarction | Medium | convergence | {"qa_id":"medium_convergence_02326","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AFF1 and PML both interact with a shared protein entity. Evidence indicates that SIAH-1/2 binds to and targets this entity for proteasome-mediated degradatio... | |
medium_convergence_02327 | Dengue virus and Enterovirus A both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) shows a log2 fold change of approximately -2.096 and an adjusted p-value of 0.04259. Which cellular component is this gene located in? | transcription elongation factor complex | Medium | convergence | {"qa_id":"medium_convergence_02327","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Enterovirus A both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) shows a log2 fold... | |
medium_convergence_02328 | KPNB1 and NUP214 both interact with a shared protein partner. Evidence regarding one such partner states: 'The C terminus binds importin-beta through RanGTP.' Which protein is encoded by the gene corresponding to this shared partner? | Nuclear pore complex protein Nup50 | Medium | convergence | {"qa_id":"medium_convergence_02328","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KPNB1 and NUP214 both interact with a shared protein partner. Evidence regarding one such partner states: 'The C terminus binds importin-beta through RanGTP.... | |
medium_convergence_02329 | ISL2 and LMO4 both interact with a shared protein partner. Evidence regarding this partner states: 'This mutant protein could still bind the shared partner but no longer associated with CtIP or BRCA1.' Which protein is encoded by the gene corresponding to this shared partner? | LIM domain-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02329","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ISL2 and LMO4 both interact with a shared protein partner. Evidence regarding this partner states: 'This mutant protein could still bind the shared partner b... | |
medium_convergence_02330 | Both Human alphaherpesvirus 1 and Influenza A virus are known to downregulate a specific shared gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately -1.378 and an adjusted p-value of 0.03816. Which cell type is this gene enriched in? | intermediate monocyte | Medium | convergence | {"qa_id":"medium_convergence_02330","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Influenza A virus are known to downregulate a specific shared gene. Experimental data for this gene in a monocytic leukemia... | |
medium_convergence_02331 | Human polyomavirus 1 and Human immunodeficiency virus 1 both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) reports a log2 fold change of approximately 1.86 and an adjusted p-value of 0.0017. Which protein is encoded by this gene? | Nuclear factor NF-kappa-B p105 subunit | Medium | convergence | {"qa_id":"medium_convergence_02331","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Human immunodeficiency virus 1 both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE... | |
medium_convergence_02332 | RUNX1 and CBFB both interact with a specific protein. Evidence regarding this interaction states: 'Using yeast two-hybrid screening, we demonstrate that Yes-associated protein (YAP) binds to the PY motif of PEBP2alpha through its WW domain.' Which protein is encoded by the gene corresponding to this interacting entity? | Transcriptional coactivator YAP1 | Medium | convergence | {"qa_id":"medium_convergence_02332","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RUNX1 and CBFB both interact with a specific protein. Evidence regarding this interaction states: 'Using yeast two-hybrid screening, we demonstrate that Yes-... | |
medium_convergence_02333 | CDK12 and EAF1 both interact with a common protein partner. Experimental evidence indicates that endogenous EAF1 and this shared partner were co-immunoprecipitated from multiple cell lines using specific antibodies. Which protein is encoded by the gene corresponding to this shared partner? | RNA polymerase II elongation factor ELL | Medium | convergence | {"qa_id":"medium_convergence_02333","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK12 and EAF1 both interact with a common protein partner. Experimental evidence indicates that endogenous EAF1 and this shared partner were co-immunoprecip... | |
medium_convergence_02334 | NDUFA9 and PRKN share a common interacting partner. Evidence regarding this shared partner states: 'The three most abundant interacting proteins were the voltage-dependent anion channels 1, 2, and 3 (VDACs 1, 2, and 3), pore-forming proteins in the outer mitochondrial membrane.' Which protein is encoded by this shared ... | Non-selective voltage-gated ion channel VDAC3 | Medium | convergence | {"qa_id":"medium_convergence_02334","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NDUFA9 and PRKN share a common interacting partner. Evidence regarding this shared partner states: 'The three most abundant interacting proteins were the vol... | |
medium_convergence_02335 | AXIN1 and CAV1 share a common binding partner. Evidence indicates that essential domains of Axin are responsible for the interaction with this partner, as well as for the partner-mediated down-regulation and ubiquitination of Axin. Which disease is associated with this shared binding partner? | lung adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_02335","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AXIN1 and CAV1 share a common binding partner. Evidence indicates that essential domains of Axin are responsible for the interaction with this partner, as we... | |
medium_convergence_02336 | LIMA1 and ACTB both interact with a shared protein. Experimental evidence indicates that GST fusions of the G2-G3 or G4-G6 repeats of this shared protein co-sediment with KIF14 and EPLIN, respectively, consistent with a direct association. Which cell type is enriched for this shared protein? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_02336","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LIMA1 and ACTB both interact with a shared protein. Experimental evidence indicates that GST fusions of the G2-G3 or G4-G6 repeats of this shared protein co-... | |
medium_convergence_02337 | Both Human alphaherpesvirus 1 and Dengue virus have been shown to upregulate a specific gene. In a study using a monocytic leukemia cell line (GSE114966), the upregulation of this gene was associated with a log2 fold change of approximately 1.086 and an adjusted p-value of 0.008399. Which disease is associated with thi... | cerebellar ataxia, brain abnormalities, and cardiac conduction defects | Medium | convergence | {"qa_id":"medium_convergence_02337","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Dengue virus have been shown to upregulate a specific gene. In a study using a monocytic leukemia cell line (GSE114966), th... | |
medium_convergence_02338 | CHEK1 and KDM1A share multiple interacting partners. One such partner is described in the following evidence: 'Here we identified that Chk1 directly interacts with a regulatory subunit of protein phosphatase 1 and preferentially phosphorylates it at Ser20, which is essential for its interaction with PP1cβ and subsequen... | Protein phosphatase 1 regulatory subunit 12A | Medium | convergence | {"qa_id":"medium_convergence_02338","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK1 and KDM1A share multiple interacting partners. One such partner is described in the following evidence: 'Here we identified that Chk1 directly interact... | |
medium_convergence_02339 | Interferon beta-1b and Bortezomib share a common interacting drug. Evidence indicates that the combined treatment of cells with this shared drug (referred to as VPA) and Bortezomib resulted in an additive killing effect. Which disease is this shared drug indicated for? | bipolar disorder | Medium | convergence | {"qa_id":"medium_convergence_02339","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Interferon beta-1b and Bortezomib share a common interacting drug. Evidence indicates that the combined treatment of cells with this shared drug (referred to... | |
medium_convergence_02340 | CTNND1 and RHOA share multiple interacting partners. One such partner is described in evidence stating that GST-fusion proteins containing the catalytic domain of a specific receptor-type tyrosine-protein phosphatase with a substrate-trapping D/A mutation were found to interact with p120(ctn), a component of adherens j... | Receptor-type tyrosine-protein phosphatase eta | Medium | convergence | {"qa_id":"medium_convergence_02340","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNND1 and RHOA share multiple interacting partners. One such partner is described in evidence stating that GST-fusion proteins containing the catalytic doma... | |
medium_convergence_02341 | HUWE1 and MDH2 both interact with a common protein partner. Evidence indicates that this partner, identified as the 20S proteasomal core subunit alpha-type 1, acts as a molecular scaffold that binds MDH2 and accelerates its degradation by promoting the binding of ubiquitinated MDH2 to the proteasome. Which gene encodes... | Proteasome subunit alpha type-1 | Medium | convergence | {"qa_id":"medium_convergence_02341","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HUWE1 and MDH2 both interact with a common protein partner. Evidence indicates that this partner, identified as the 20S proteasomal core subunit alpha-type 1... | |
medium_convergence_02342 | Dengue virus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) shows a log2 fold change of approximately -2.46 and an adjusted p-value of approximately 0.036. Which protein is encoded by this gene? | Histone H1.4 | Medium | convergence | {"qa_id":"medium_convergence_02342","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) shows a log2 fold ... | |
medium_convergence_02343 | PRKCI and CASP8 both interact with a shared protein. Evidence indicates that Caspase 8 interacts with multiple proteins involved in NF-kappaB pathway activation, specifically listing the serine-threonine kinases RIPK1, NIK, IKK1, and IKK2. Which protein product is encoded by the gene corresponding to the shared entity ... | Receptor-interacting serine/threonine-protein kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_02343","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKCI and CASP8 both interact with a shared protein. Evidence indicates that Caspase 8 interacts with multiple proteins involved in NF-kappaB pathway activat... | |
medium_convergence_02344 | Both Orthohepevirus A and Primate bocaparvovirus 1 are associated with the downregulation of a specific gene. Experimental data for this gene in hepatocytes (from study GSE135619) reports a log2 fold change of -1.495 and an adjusted p-value of 0.04032. Which protein is encoded by this gene? | Apoptosis regulator BAX | Medium | convergence | {"qa_id":"medium_convergence_02344","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Primate bocaparvovirus 1 are associated with the downregulation of a specific gene. Experimental data for this gene in hepatocytes ... | |
medium_convergence_02345 | The basicranium and the sphenoid bone pre-cartilage condensation are both components of a specific anatomical structure. Contextual evidence states: 'The base of skull is the most inferior area of the skull, composed of the endocranium and lower parts of the skull roof.' Based on this description, which anatomical enti... | primary subdivision of skull | Medium | convergence | {"qa_id":"medium_convergence_02345","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The basicranium and the sphenoid bone pre-cartilage condensation are both components of a specific anatomical structure. Contextual evidence states: 'The bas... | |
medium_convergence_02347 | ORC3 and MCM5 each interact with more than one shared protein partner. Evidence concerning one such shared partner reports the following binary interactions: HsOrc2-HsOrc3, HsOrc2-HsOrc4, HsOrc3-HsOrc4, HsOrc2-HsOrc6, and HsOrc3-HsOrc6. Which protein is connected to that shared partner through the 'encodes' relationshi... | Origin recognition complex subunit 6 | Medium | convergence | {"qa_id":"medium_convergence_02347","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ORC3 and MCM5 each interact with more than one shared protein partner. Evidence concerning one such shared partner reports the following binary interactions:... | |
medium_convergence_02348 | AKT1 and MDM2 share multiple interacting partners. One such shared partner is implicated in the direct regulation of FOXO ubiquitination, a conclusion supported by evidence that this partner and FOXO co-immunoprecipitate. Which protein is encoded by this specific shared partner? | Forkhead box protein O4 | Medium | convergence | {"qa_id":"medium_convergence_02348","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKT1 and MDM2 share multiple interacting partners. One such shared partner is implicated in the direct regulation of FOXO ubiquitination, a conclusion suppor... | |
medium_convergence_02349 | COG4 and COG6 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Our results suggest that COG4 serves as a core component of the complex by interacting directly with COG1, COG2, COG5, and this shared partner.' Which molecular function is enabled by that sp... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_02349","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COG4 and COG6 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Our results suggest that COG... | |
medium_convergence_02350 | HDAC2 and MECP2 share multiple protein interaction partners. One such shared partner forms a complex with Myt1, HDAC1, and HDAC2, as demonstrated by co-immunoprecipitation from transfected mammalian cells. Which protein is encoded by the gene corresponding to this shared interaction partner? | Paired amphipathic helix protein Sin3b | Medium | convergence | {"qa_id":"medium_convergence_02350","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC2 and MECP2 share multiple protein interaction partners. One such shared partner forms a complex with Myt1, HDAC1, and HDAC2, as demonstrated by co-immun... | |
medium_convergence_02351 | Both the regulation of mast cell apoptotic process and the regulation of neutrophil apoptotic process are subtypes of a shared biological process. Evidence for one such shared entity states: 'Any process that modulates the frequency, rate, or extent of mast cell apoptotic process.' Which biological process is directly ... | myeloid cell apoptotic process | Medium | convergence | {"qa_id":"medium_convergence_02351","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the regulation of mast cell apoptotic process and the regulation of neutrophil apoptotic process are subtypes of a shared biological process. Evidence f... | |
medium_convergence_02352 | The androgen receptor (AR) and the E2 ubiquitin-conjugating enzyme UBE2E1 both interact with a specific shared protein. Evidence indicates that this shared protein, along with RNF20, is capable of functionally and physically interacting with AR to modulate its transcriptional activity in intact cells. Which protein is ... | E3 ubiquitin-protein ligase BRE1B | Medium | convergence | {"qa_id":"medium_convergence_02352","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The androgen receptor (AR) and the E2 ubiquitin-conjugating enzyme UBE2E1 both interact with a specific shared protein. Evidence indicates that this shared p... | |
medium_convergence_02353 | Omeprazole and Nizatidine both interact with a specific drug. Evidence indicates that the plasma concentration of this drug increases when coadministered with omeprazole in healthy subjects, likely due to increased bioavailability resulting from elevated gastric pH. Which disease is this drug indicated for? | HIV infectious disease | Medium | convergence | {"qa_id":"medium_convergence_02353","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Omeprazole and Nizatidine both interact with a specific drug. Evidence indicates that the plasma concentration of this drug increases when coadministered wit... | |
medium_convergence_02354 | Human alphaherpesvirus 1 and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of -1.406 and an adjusted p-value of 0.002963. Which disease is associated with this gene through genomic alterations? | colon carcinoma | Medium | convergence | {"qa_id":"medium_convergence_02354","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE11496... | |
medium_convergence_02355 | DAB1 and GRIN2A both interact with a shared protein entity. Evidence indicates that signaling through specific receptors requires the interaction of their cytoplasmic tails with the intracellular adaptor protein Disabled-1 (DAB1). Which protein is encoded by the gene corresponding to this shared entity? | Low-density lipoprotein receptor-related protein 8 | Medium | convergence | {"qa_id":"medium_convergence_02355","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAB1 and GRIN2A both interact with a shared protein entity. Evidence indicates that signaling through specific receptors requires the interaction of their cy... | |
medium_convergence_02356 | Dengue virus and Enterovirus A both downregulate a specific gene. Experimental data from a hepatoma cell line study (GSE110512) indicates that this gene has a log2 fold change of approximately -1.60 and an adjusted p-value of 0.0447. Which biological process is this gene involved in? | positive regulation of transcription by RNA polymerase II | Medium | convergence | {"qa_id":"medium_convergence_02356","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Enterovirus A both downregulate a specific gene. Experimental data from a hepatoma cell line study (GSE110512) indicates that this gene has ... | |
medium_convergence_02357 | EIF2B1 and EIF2B4 both interact with a common protein partner. Experimental evidence indicates that removing either the N- or C-terminal conserved domains of this partner leads to a significant loss of GEF activity and disrupts its interaction with the alpha, gamma, and delta subunits of eIF2B. Which protein is encoded... | Translation initiation factor eIF2B subunit epsilon | Medium | convergence | {"qa_id":"medium_convergence_02357","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF2B1 and EIF2B4 both interact with a common protein partner. Experimental evidence indicates that removing either the N- or C-terminal conserved domains of... | |
medium_convergence_02358 | MCM10 and CLSPN both interact with a shared protein. Evidence indicates that HsMcm10 associates with the human version of this shared protein when overexpressed in COS-1 cells. Which disease is associated with this shared protein? | Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome | Medium | convergence | {"qa_id":"medium_convergence_02358","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MCM10 and CLSPN both interact with a shared protein. Evidence indicates that HsMcm10 associates with the human version of this shared protein when overexpres... | |
medium_convergence_02359 | CHEK1 and EGFR share a common interacting partner. Experimental evidence indicates that Chk1 binds to and phosphorylates this partner, along with Cdc25A and Cdc25B, as part of a group of dual-specificity protein phosphatases that regulate cell cycle transitions by dephosphorylating cyclin-dependent kinases. Which disea... | schizophrenia | Medium | convergence | {"qa_id":"medium_convergence_02359","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK1 and EGFR share a common interacting partner. Experimental evidence indicates that Chk1 binds to and phosphorylates this partner, along with Cdc25A and ... | |
medium_convergence_02360 | CDCA5 and CDCA8 both interact with a specific protein. Evidence indicates that approximately half of Aurora B in mitotic cells forms a complex with this protein, Borealin, and Survivin, and that Borealin binds both Survivin and this protein in vitro. Which protein is encoded by the gene corresponding to this interactin... | Inner centromere protein | Medium | convergence | {"qa_id":"medium_convergence_02360","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDCA5 and CDCA8 both interact with a specific protein. Evidence indicates that approximately half of Aurora B in mitotic cells forms a complex with this prot... | |
medium_convergence_02361 | CFTR and DDI1 share multiple interacting partners. One such partner is described in the following context: 'Here, we report that [a nuclear receptor interacting protein] promotes ESCC tumor cell growth and resistance to CRT in ESCC cells by increasing and binding to DNA-damage inducible 1 homolog 1 and RTF2 (homologous... | leukemia | Medium | convergence | {"qa_id":"medium_convergence_02361","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CFTR and DDI1 share multiple interacting partners. One such partner is described in the following context: 'Here, we report that [a nuclear receptor interact... | |
medium_convergence_02362 | CCT2 and WDFY3 share interaction partners. One such shared partner is characterized by its ability to associate with aggregation-prone proteins independent of cargo ubiquitination and to interact with autophagosome marker ATG8s through a non-classical VLIR motif. Which protein is encoded by the gene corresponding to th... | Microtubule-associated protein 1 light chain 3 gamma | Medium | convergence | {"qa_id":"medium_convergence_02362","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCT2 and WDFY3 share interaction partners. One such shared partner is characterized by its ability to associate with aggregation-prone proteins independent o... | |
medium_convergence_02363 | CYLD and MYC both interact with a shared protein. Evidence indicates that this shared protein directly interacts with c-Myc and stabilizes its protein levels by preventing proteasomal degradation. Which protein is encoded by the gene corresponding to this shared entity? | Polypyrimidine tract-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02363","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CYLD and MYC both interact with a shared protein. Evidence indicates that this shared protein directly interacts with c-Myc and stabilizes its protein levels... | |
medium_convergence_02364 | KCND3 and KCNE1 both enable a shared molecular function. Evidence regarding one of these functions states: 'The human cardiac fast transient outward K+ channel is composed of the KV4.3 α subunit encoded by KCND3 and the K+ channel‑interacting protein 2 (KChIP2) β subunit, and determines the early repolarization of the ... | voltage-gated potassium channel activity | Medium | convergence | {"qa_id":"medium_convergence_02364","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KCND3 and KCNE1 both enable a shared molecular function. Evidence regarding one of these functions states: 'The human cardiac fast transient outward K+ chann... | |
medium_convergence_02365 | BMP2 and GDF5 both interact with a specific receptor. Evidence regarding this receptor states: 'We have used BMP-2 as a key representative of the BMPs to identify the epitopes for type I and type II receptor binding by mutational interaction analyses and have solved the crystal structure of a BMP2:BMPR-IA receptor ecto... | CREST syndrome | Medium | convergence | {"qa_id":"medium_convergence_02365","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMP2 and GDF5 both interact with a specific receptor. Evidence regarding this receptor states: 'We have used BMP-2 as a key representative of the BMPs to ide... | |
medium_convergence_02367 | TNK2 and AMOT both interact with a shared protein. Evidence regarding this shared partner states: 'Here, we have identified a new ACK1-binding partner, the E3 ubiquitin ligase [REDACTED], which binds ACK1 via a conserved PPXY-containing region.' Which protein is encoded by the gene corresponding to this shared partner? | E3 ubiquitin-protein ligase NEDD4-like | Medium | convergence | {"qa_id":"medium_convergence_02367","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TNK2 and AMOT both interact with a shared protein. Evidence regarding this shared partner states: 'Here, we have identified a new ACK1-binding partner, the E... | |
medium_convergence_02368 | Morphine and Cyproheptadine both interact with a specific drug. Clinical evidence regarding this drug indicates that in the treatment group, cumulative morphine consumption from 0 to 48 hours postoperatively was lower (11 mg [5 to 21] versus 6 mg [0 to 17]) and the incidence of postoperative nausea and vomiting was red... | anxiety | Medium | convergence | {"qa_id":"medium_convergence_02368","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Morphine and Cyproheptadine both interact with a specific drug. Clinical evidence regarding this drug indicates that in the treatment group, cumulative morph... | |
medium_convergence_02369 | KCNQ1 and SCN5A are both involved in more than one shared biological process. One such shared process is linked to evidence stating: 'These data define KVLQT1 as a novel cardiac potassium channel gene and show that mutations in this gene cause susceptibility to ventricular tachyarrhythmias and sudden death.' Which biol... | ventricular cardiac muscle cell membrane repolarization | Medium | convergence | {"qa_id":"medium_convergence_02369","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KCNQ1 and SCN5A are both involved in more than one shared biological process. One such shared process is linked to evidence stating: 'These data define KVLQT... | |
medium_convergence_02371 | HIPK2 and GSK3B share multiple interacting partners. One such shared partner is supported by evidence stating: 'Furthermore, co-immunoprecipitation analysis revealed a physical association between endogenous GSK3 beta and a MAP3K family member in HEK293 cells.' Which protein is encoded by this shared partner? | Mitogen-activated protein kinase kinase kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_02371","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HIPK2 and GSK3B share multiple interacting partners. One such shared partner is supported by evidence stating: 'Furthermore, co-immunoprecipitation analysis ... | |
medium_convergence_02372 | SNW1 and PML share multiple interacting partners. One such shared partner is characterized by evidence stating: 'Binding assays indicated that SKIP interacts with a retinoic acid receptor in a RA-dependent manner, through a region that overlaps the binding site for SIRT1.' Which protein is encoded by this shared intera... | Retinoic acid receptor alpha | Medium | convergence | {"qa_id":"medium_convergence_02372","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SNW1 and PML share multiple interacting partners. One such shared partner is characterized by evidence stating: 'Binding assays indicated that SKIP interacts... | |
medium_convergence_02373 | ADRB2 and AMPH both interact with a shared protein partner. Evidence regarding this partner states: 'They interact with dynamin and synaptojanin via their COOH-terminal SH3 domain, whereas their central regions contain binding sites for clathrin and for the clathrin adaptor AP-2.' Which disease is associated with this ... | meningioma | Medium | convergence | {"qa_id":"medium_convergence_02373","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ADRB2 and AMPH both interact with a shared protein partner. Evidence regarding this partner states: 'They interact with dynamin and synaptojanin via their CO... | |
medium_convergence_02374 | Both Vaccinia virus and Dengue virus are known to upregulate a specific gene. Experimental data from a study on cervical adenocarcinoma cell lines (GSE11238) indicates that for one such shared target, the log2 fold change is approximately 3.06 and the adjusted p-value is approximately 4.91e-09. Which disease is associa... | primordial dwarfism-immunodeficiency-lipodystrophy syndrome | Medium | convergence | {"qa_id":"medium_convergence_02374","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Vaccinia virus and Dengue virus are known to upregulate a specific gene. Experimental data from a study on cervical adenocarcinoma cell lines (GSE11238)... | |
medium_convergence_02375 | ERBB4 and MEMO1 share multiple binding partners. One shared partner is described in evidence stating: 'Like NRG-1, the EGF-like domain of the new ligands binds to both the ErbB3- and the ErbB4-receptor tyrosine kinases.' Which protein is encoded by this shared partner? | Pro-neuregulin-2, membrane-bound isoform | Medium | convergence | {"qa_id":"medium_convergence_02375","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB4 and MEMO1 share multiple binding partners. One shared partner is described in evidence stating: 'Like NRG-1, the EGF-like domain of the new ligands bin... | |
medium_convergence_02377 | CREBBP and PSMD4 both interact with a specific shared protein. Evidence regarding this shared protein states: 'A co-immunoprecipitation assay further demonstrated that a fraction of endogenous [shared protein] is associated with each of the three HATs.' Which protein is encoded by this shared entity? | Transcription factor E2-alpha | Medium | convergence | {"qa_id":"medium_convergence_02377","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and PSMD4 both interact with a specific shared protein. Evidence regarding this shared protein states: 'A co-immunoprecipitation assay further demonst... | |
medium_convergence_02378 | STUB1 and HDAC2 both interact with a specific shared protein. Experimental evidence indicates that immunoprecipitation experiments demonstrated an increased association of this shared protein with the E3 ubiquitin ligase CHIP. Which protein is encoded by this shared gene? | T-cell acute lymphocytic leukemia protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02378","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and HDAC2 both interact with a specific shared protein. Experimental evidence indicates that immunoprecipitation experiments demonstrated an increased ... | |
medium_convergence_02379 | CHD3 and HDAC1 each interact with more than one shared protein partner. Evidence concerning one such shared partner reports: 'In the ovary, this protein interacted with NuRD proteins CHD4 and HDAC1 and the core cohesin complex protein RAD21.' Which protein is encoded by this shared partner? | Metastasis-associated protein MTA3 | Medium | convergence | {"qa_id":"medium_convergence_02379","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD3 and HDAC1 each interact with more than one shared protein partner. Evidence concerning one such shared partner reports: 'In the ovary, this protein inte... | |
medium_convergence_02380 | AGR2 and ESR1 both interact with a common protein partner. Experimental evidence for one such partner states: 'We show that these two proteins physically interact with each other both in vitro as well as in vivo by GST-pull down and coimmunoprecipitation, respectively.' Which protein is encoded by the gene correspondin... | Profilin-1 | Medium | convergence | {"qa_id":"medium_convergence_02380","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AGR2 and ESR1 both interact with a common protein partner. Experimental evidence for one such partner states: 'We show that these two proteins physically int... | |
medium_convergence_02381 | Human gammaherpesvirus 4 and Severe acute respiratory syndrome-related coronavirus both downregulate a specific gene. Evidence for this gene in gamma delta T-lymphocytes (from study GSE13906) reports a log2 fold change of -1.319 and an adjusted p-value of 0.03811. Which biological process is this gene involved in? | apoptotic process | Medium | convergence | {"qa_id":"medium_convergence_02381","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human gammaherpesvirus 4 and Severe acute respiratory syndrome-related coronavirus both downregulate a specific gene. Evidence for this gene in gamma delta T... | |
medium_convergence_02383 | EGFR and EPHA2 share a common interaction partner. Experimental evidence indicates that this shared partner interacts with both Cbl and EGFR. Which cell type is enriched for this shared partner? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_02383","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and EPHA2 share a common interaction partner. Experimental evidence indicates that this shared partner interacts with both Cbl and EGFR. Which cell type... | |
medium_convergence_02384 | Both POLA1 and POLE interact with a common partner protein. Evidence regarding this partner states: 'We have identified a short conserved motif at the extreme C terminus of pol α that is critical for interaction of the yeast ortholog pol1 with primase.' Which protein is encoded by this shared partner? | DNA primase small subunit | Medium | convergence | {"qa_id":"medium_convergence_02384","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both POLA1 and POLE interact with a common partner protein. Evidence regarding this partner states: 'We have identified a short conserved motif at the extrem... | |
medium_convergence_02385 | LAMA5 and CDC42 both interact with a common protein partner. Evidence regarding this partner states: 'We have shown that this partner preferentially binds to CDC42 in the presence of GTP and that CRIB motif is essential for this interaction.' Which disease is associated with this protein partner via a biomarker relatio... | breast cancer | Medium | convergence | {"qa_id":"medium_convergence_02385","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LAMA5 and CDC42 both interact with a common protein partner. Evidence regarding this partner states: 'We have shown that this partner preferentially binds to... | |
medium_convergence_02386 | COMMD1 and CUL3 both interact with a specific adaptor protein. Evidence indicates that this adaptor forms a complex with CUL3 to function as an E3 ubiquitin ligase that targets hypophosphorylated 4E-BP1. Which protein is encoded by this adaptor gene? | Kelch-like protein 25 | Medium | convergence | {"qa_id":"medium_convergence_02386","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COMMD1 and CUL3 both interact with a specific adaptor protein. Evidence indicates that this adaptor forms a complex with CUL3 to function as an E3 ubiquitin ... | |
medium_convergence_02388 | Enterovirus A and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in rhabdomyosarcoma cells shows a log2 fold change of approximately -1.54 and an adjusted p-value of 0.00063. Which protein is encoded by this gene? | Arginine vasopressin-induced protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02388","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Enterovirus A and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in rhabdomyosarcoma cells shows a log2 fold change of a... | |
medium_convergence_02389 | KAT5 and EHMT2 share multiple interacting partners. One such shared partner is reported to directly bind G9a both in vivo and in vitro and to colocalize with it in the nucleus during DNA replication. Which disease is associated with this specific shared partner through genomic alterations? | Ogden syndrome | Medium | convergence | {"qa_id":"medium_convergence_02389","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KAT5 and EHMT2 share multiple interacting partners. One such shared partner is reported to directly bind G9a both in vivo and in vitro and to colocalize with... | |
medium_convergence_02391 | AKT1 and NTRK1 share common interaction partners. One such shared partner is described in evidence stating: 'Furthermore, we demonstrated a direct interaction between Akt and this protein.' Which protein is encoded by this shared interaction partner? | TNF receptor-associated factor 4 | Medium | convergence | {"qa_id":"medium_convergence_02391","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKT1 and NTRK1 share common interaction partners. One such shared partner is described in evidence stating: 'Furthermore, we demonstrated a direct interactio... | |
medium_convergence_02392 | Primate erythroparvovirus 1 and Primate bocaparvovirus 1 each upregulate more than one shared gene. Evidence concerning one such shared entity reports a log2 fold change of 1.023 and an adjusted p-value of 0.04293. Which protein is encoded by that entity? | Interferon-stimulated gene 20 kDa protein | Medium | convergence | {"qa_id":"medium_convergence_02392","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Primate erythroparvovirus 1 and Primate bocaparvovirus 1 each upregulate more than one shared gene. Evidence concerning one such shared entity reports a log2... | |
medium_convergence_02393 | STAT3 and TP53 both interact with a specific protein. Experimental evidence indicates that this protein directly interacts with p53, and this interaction underlies the inhibitory effects on p53 target gene expression. Which protein product is encoded by this interacting protein? | Twist-related protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02393","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STAT3 and TP53 both interact with a specific protein. Experimental evidence indicates that this protein directly interacts with p53, and this interaction und... | |
medium_convergence_02394 | RNF168 and BRCA1 both interact with a specific shared protein. Evidence indicates that this shared protein is a BRCA1-interacting protein identified in humans. Which protein product is encoded by the gene corresponding to this shared entity? | BRCA1-A complex subunit RAP80 | Medium | convergence | {"qa_id":"medium_convergence_02394","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RNF168 and BRCA1 both interact with a specific shared protein. Evidence indicates that this shared protein is a BRCA1-interacting protein identified in human... | |
medium_convergence_02395 | PARP1 and PRKDC both interact with a specific shared protein. Experimental evidence indicates that PARP-1 binds directly to this protein and forms a complex with it and Ku70/80. Which gene encodes this shared protein? | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN | Medium | convergence | {"qa_id":"medium_convergence_02395","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and PRKDC both interact with a specific shared protein. Experimental evidence indicates that PARP-1 binds directly to this protein and forms a complex ... | |
medium_convergence_02396 | Both Human polyomavirus 1 and Human immunodeficiency virus 1 are reported to upregulate a specific gene. Experimental data for this gene in renal epithelial cells (from study GSE135833) indicates a log2 fold change of approximately 2.295 and an adjusted p-value of 0.01829. Which disease is associated with this gene? | glioma | Medium | convergence | {"qa_id":"medium_convergence_02396","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human polyomavirus 1 and Human immunodeficiency virus 1 are reported to upregulate a specific gene. Experimental data for this gene in renal epithelial ... | |
medium_convergence_02397 | CRKL and EGFR share multiple interacting partners. One such partner is characterized by evidence stating: 'The direct binding of the SH2 domain of CrkL to this transcription factor was demonstrated in far Western blotting and pull-down experiments using the glutathione S-transferase (GST) fusion construct CrkL-SH2.' Wh... | nucleus | Medium | convergence | {"qa_id":"medium_convergence_02397","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRKL and EGFR share multiple interacting partners. One such partner is characterized by evidence stating: 'The direct binding of the SH2 domain of CrkL to th... | |
medium_convergence_02398 | EXOSC9 and DCP1A share a common binding partner. Evidence indicates that mutation of six C-terminal lysines in this shared partner suppresses decapping activity and impairs its interaction with the mRNA decay factors DCP2, EDC4, and the partner itself, but not EDC3, thereby remodeling P-body architecture. Which cell ty... | basophil | Medium | convergence | {"qa_id":"medium_convergence_02398","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EXOSC9 and DCP1A share a common binding partner. Evidence indicates that mutation of six C-terminal lysines in this shared partner suppresses decapping activ... | |
medium_convergence_02399 | Human betaherpesvirus 5 and Human gammaherpesvirus 4 both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (study GSE130665) reports a log2 fold change of -1.216 and an adjusted p-value of 0.04117. Which protein is encoded by this gene? | G0/G1 switch protein 2 | Medium | convergence | {"qa_id":"medium_convergence_02399","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Human gammaherpesvirus 4 both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (st... | |
medium_convergence_02400 | CDK8 and FAM120B both physically interact with a shared protein. Evidence indicates that this shared protein, also known as 13L, physically links the CDK8 module to the Mediator complex. Which disease is associated with this shared protein? | intellectual developmental disorder 61 | Medium | convergence | {"qa_id":"medium_convergence_02400","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK8 and FAM120B both physically interact with a shared protein. Evidence indicates that this shared protein, also known as 13L, physically links the CDK8 mo... | |
medium_convergence_02402 | PRKDC and YWHAE share common interaction partners. One such shared partner is associated with a histone acetyltransferase, which has been found to interact with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a key component of nonhomologous end-joining (NHEJ) repair. Which protein is encoded by this sha... | Histone acetyltransferase KAT8 | Medium | convergence | {"qa_id":"medium_convergence_02402","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKDC and YWHAE share common interaction partners. One such shared partner is associated with a histone acetyltransferase, which has been found to interact w... | |
medium_convergence_02403 | EIF4A1 and EIF3L each interact with more than one shared protein partner. Evidence concerning one such shared partner reports that Far-Western analysis and coimmunoprecipitation experiments were used to demonstrate that eIF4GII directly interacts with this entity, eIF4A, and eIF3. Which protein is encoded by the gene c... | Eukaryotic translation initiation factor 4 gamma 1 | Medium | convergence | {"qa_id":"medium_convergence_02403","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF4A1 and EIF3L each interact with more than one shared protein partner. Evidence concerning one such shared partner reports that Far-Western analysis and c... | |
medium_convergence_02404 | CHMP1A and TSG101 both interact with a common protein component of the human ESCRT-I complex. Experimental evidence indicates that this shared protein, along with TSG101, co-immunoprecipitated with VPS37B-FLAG, and the three proteins comigrated together in soluble complexes of the correct size for human ESCRT-I (approx... | Vacuolar protein sorting-associated protein 28 homolog | Medium | convergence | {"qa_id":"medium_convergence_02404","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHMP1A and TSG101 both interact with a common protein component of the human ESCRT-I complex. Experimental evidence indicates that this shared protein, along... | |
medium_convergence_02405 | FAF2 and PRKN (PARK2) share common interacting partners. One such shared partner is described by evidence stating: 'In cellular models, parkin ubiquitinates a specific phosphatase and thereby regulates its level through the proteasome system, whereas clinically relevant parkin mutants fail to do so.' Which protein is e... | Tyrosine-protein phosphatase non-receptor type 5 | Medium | convergence | {"qa_id":"medium_convergence_02405","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FAF2 and PRKN (PARK2) share common interacting partners. One such shared partner is described by evidence stating: 'In cellular models, parkin ubiquitinates ... | |
medium_convergence_02406 | Both macular hair cells and cochlear auditory hair cells are subtypes of a specific cell type. Evidence indicates that this shared cell type is located in the macula and is sensitive to auditory stimuli. Which anatomical structure is this shared cell type a part of? | ear | Medium | convergence | {"qa_id":"medium_convergence_02406","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both macular hair cells and cochlear auditory hair cells are subtypes of a specific cell type. Evidence indicates that this shared cell type is located in th... | |
medium_convergence_02407 | KRAS and MDM2 share a common interacting partner. Evidence indicates that this shared partner, specifically its ribosomal protein component, binds to the acidic domain of MDM2, thereby inhibiting MDM2-mediated p53 ubiquitination and degradation and extending p53 half-life. Which disease is associated with this shared i... | acute myeloid leukemia | Medium | convergence | {"qa_id":"medium_convergence_02407","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KRAS and MDM2 share a common interacting partner. Evidence indicates that this shared partner, specifically its ribosomal protein component, binds to the aci... | |
medium_convergence_02408 | MYC and NONO each interact with more than one shared gene product. Evidence concerning one such shared entity states: 'We report that a DBHS (Drosophila behaviour, human splicing) family protein, p54(nrb), binds both BRG1 (Brahma-related gene 1) and Brm (Brahma), catalytic subunits of the SWI/SNF (switch/sucrose non-fe... | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 | Medium | convergence | {"qa_id":"medium_convergence_02408","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and NONO each interact with more than one shared gene product. Evidence concerning one such shared entity states: 'We report that a DBHS (Drosophila beha... | |
medium_convergence_02409 | West Nile virus and Severe acute respiratory syndrome-related coronavirus both upregulate a specific gene. Experimental data for this gene in monocyte-derived dendritic cells (from study GSE136342) reports a log2 fold change of approximately 1.205 and an adjusted p-value of 0.01096. Which disease is associated with thi... | intervertebral disk degenerative disorder | Medium | convergence | {"qa_id":"medium_convergence_02409","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"West Nile virus and Severe acute respiratory syndrome-related coronavirus both upregulate a specific gene. Experimental data for this gene in monocyte-derive... | |
medium_convergence_02410 | KRAS and MDM2 share multiple interacting partners. One such shared partner is a protein that, mechanistically, binds to the acidic domain of MDM2 and inhibits MDM2-mediated p53 ubiquitination and degradation, thereby extending the half-life of p53. Which protein is encoded by the gene corresponding to this shared partn... | Large ribosomal subunit protein eL22 | Medium | convergence | {"qa_id":"medium_convergence_02410","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KRAS and MDM2 share multiple interacting partners. One such shared partner is a protein that, mechanistically, binds to the acidic domain of MDM2 and inhibit... | |
medium_convergence_02411 | STUB1 and YWHAQ both interact with a specific protein. Evidence regarding this shared interaction partner states: 'The nonreceptor tyrosine kinase encoded by ABL1 binds to cytosolic 14-3-3 proteins and is targeted to the nucleus in the apoptotic response to DNA damage.' Which protein is encoded by the gene correspondin... | Tyrosine-protein kinase ABL1 | Medium | convergence | {"qa_id":"medium_convergence_02411","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and YWHAQ both interact with a specific protein. Evidence regarding this shared interaction partner states: 'The nonreceptor tyrosine kinase encoded by... | |
medium_convergence_02412 | ACTR1A and CC2D2A each share a binding partner. For one of these shared partners, experimental evidence indicates that the proteins can physically interact in vitro, as demonstrated by yeast two-hybrid and GST pull-down experiments. Which disease is associated with this specific shared partner via a biomarker relations... | retinal degeneration | Medium | convergence | {"qa_id":"medium_convergence_02412","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACTR1A and CC2D2A each share a binding partner. For one of these shared partners, experimental evidence indicates that the proteins can physically interact i... | |
medium_convergence_02413 | DLG4 and GRIN1 share a common interaction partner. Evidence indicates that PSD-95 binds to the cytoplasmic COOH-termini of neuroligins, which are neuronal cell adhesion molecules interacting with beta-neurexins. Additionally, the second PDZ domain of PSD-95 binds to the COOH-terminal domain of NR2 subunits (such as the... | Glutamate receptor ionotropic, NMDA 2B | Medium | convergence | {"qa_id":"medium_convergence_02413","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLG4 and GRIN1 share a common interaction partner. Evidence indicates that PSD-95 binds to the cytoplasmic COOH-termini of neuroligins, which are neuronal ce... |
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