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medium_convergence_02196 | Human polyomavirus 1 and Human immunodeficiency virus 1 both upregulate a specific gene. Evidence for this shared target in renal epithelial cells (study GSE135833) reports a log2 fold change of approximately 1.92 and an adjusted p-value of 0.0437. Which protein is encoded by this gene? | Large neutral amino acids transporter small subunit 4 | Medium | convergence | {"qa_id":"medium_convergence_02196","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Human immunodeficiency virus 1 both upregulate a specific gene. Evidence for this shared target in renal epithelial cells (study GSE... | |
medium_convergence_02197 | ATF6 and EIF2AK3 both interact with a shared protein. Evidence indicates that in the absence of stress, PEK associates with ER chaperones encoded by HSPA5 and GRP94, and this binding is released in response to ER stress. Which protein is encoded by the gene corresponding to this shared entity? | Endoplasmic reticulum chaperone BiP | Medium | convergence | {"qa_id":"medium_convergence_02197","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATF6 and EIF2AK3 both interact with a shared protein. Evidence indicates that in the absence of stress, PEK associates with ER chaperones encoded by HSPA5 an... | |
medium_convergence_02198 | EIF3G and EIF3H each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 impairs translation in vivo.' Which protein is connected to that entity through the 'encodes' relationship? | Eukaryotic translation initiation factor 3 subunit M | Medium | convergence | {"qa_id":"medium_convergence_02198","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3G and EIF3H each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Indeed, CIF-1 binds eIF-3.F and ... | |
medium_convergence_02199 | ESR1 and BRD4 share multiple interacting partners. One such shared partner is a variable component of the Mediator complex that enhances ligand-dependent ERα-mediated transcriptional activation of the CYP2C9 promoter and interacts with activated ERα via its C-terminal LXXLL motif. Which disease is associated with this ... | nephrolithiasis | Medium | convergence | {"qa_id":"medium_convergence_02199","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and BRD4 share multiple interacting partners. One such shared partner is a variable component of the Mediator complex that enhances ligand-dependent ERα... | |
medium_convergence_02200 | Both 'regulation of hormone secretion' and 'regulation of trans-synaptic signaling' are subtypes of a shared biological process. Evidence regarding one of these processes states: 'Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell.' Which biological process is the... | regulation of cellular process | Medium | convergence | {"qa_id":"medium_convergence_02200","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both 'regulation of hormone secretion' and 'regulation of trans-synaptic signaling' are subtypes of a shared biological process. Evidence regarding one of th... | |
medium_convergence_02201 | ESR1 and POLR2H share common interaction partners. One such shared partner has an isoform that, despite lacking the RING domain, binds and stabilizes estrogen receptor alpha. Which protein is encoded by this shared partner? | BRCA1-associated RING domain protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02201","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and POLR2H share common interaction partners. One such shared partner has an isoform that, despite lacking the RING domain, binds and stabilizes estroge... | |
medium_convergence_02202 | NFE2L2 and PRKCZ share multiple interacting partners. One such shared partner is implicated in evidence stating that the molecular interaction between a MAP kinase and Nrf2 was further induced by laminar flow. Which protein is encoded by this shared partner? | Mitogen-activated protein kinase 7 | Medium | convergence | {"qa_id":"medium_convergence_02202","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NFE2L2 and PRKCZ share multiple interacting partners. One such shared partner is implicated in evidence stating that the molecular interaction between a MAP ... | |
medium_convergence_02203 | FANCD2 and ATRIP both interact with a shared protein partner. Experimental evidence indicates that this shared partner interacts with FANCD2 via its C-terminal fragment (amino acids 1001-1328), as demonstrated by co-immunoprecipitation with purified proteins. Which disease is associated with this shared protein partner... | Fanconi anemia complementation group C | Medium | convergence | {"qa_id":"medium_convergence_02203","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCD2 and ATRIP both interact with a shared protein partner. Experimental evidence indicates that this shared partner interacts with FANCD2 via its C-termin... | |
medium_convergence_02204 | BMP6 and BMP7 both interact with a specific receptor protein. Contextual evidence notes that BMP-6 weakly binds to BMPR-IA (also known as ALK-3), a receptor to which BMP-2 also binds. Which protein is encoded by the gene corresponding to this receptor? | Bone morphogenetic protein receptor type-1A | Medium | convergence | {"qa_id":"medium_convergence_02204","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMP6 and BMP7 both interact with a specific receptor protein. Contextual evidence notes that BMP-6 weakly binds to BMPR-IA (also known as ALK-3), a receptor ... | |
medium_convergence_02206 | EPAS1 and MYC share multiple interacting partners. One such partner is characterized by the following mechanism: it physically interacts with HIF-2α and promotes its lysine 63 (K63)-linked polyubiquitination, thereby inhibiting the Von Hippel-Lindau (VHL) E3 ligase complex-mediated degradation of HIF-2α. Which cellular... | mitochondrion | Medium | convergence | {"qa_id":"medium_convergence_02206","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EPAS1 and MYC share multiple interacting partners. One such partner is characterized by the following mechanism: it physically interacts with HIF-2α and prom... | |
medium_convergence_02207 | NONO and BTRC each interact with more than one shared protein. Evidence concerning one shared entity reports that SUMO2 conjugation facilitated its interaction with β-TrCP, leading to its proteasomal degradation. Which protein is connected to that entity through the 'encodes' relationship? | Period circadian protein homolog 2 | Medium | convergence | {"qa_id":"medium_convergence_02207","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NONO and BTRC each interact with more than one shared protein. Evidence concerning one shared entity reports that SUMO2 conjugation facilitated its interacti... | |
medium_convergence_02208 | EWSR1 and XRCC6 share multiple interacting partners. One such shared partner is identified in experimental evidence stating that Ku proteins were found to interact with a transcription factor via GST-pull down followed by mass spectrometry. Which cellular component is this shared partner located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_02208","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EWSR1 and XRCC6 share multiple interacting partners. One such shared partner is identified in experimental evidence stating that Ku proteins were found to in... | |
medium_convergence_02209 | HNRNPD and RNF4 both interact with a shared protein. Evidence regarding this shared partner states: 'Using this domain as a probe, we performed a yeast two-hybrid screening and we found that [shared partner], a nuclear matrix-associated protein, exhibits protein-protein interaction to this region.' Which protein is enc... | Scaffold attachment factor B1 | Medium | convergence | {"qa_id":"medium_convergence_02209","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HNRNPD and RNF4 both interact with a shared protein. Evidence regarding this shared partner states: 'Using this domain as a probe, we performed a yeast two-h... | |
medium_convergence_02211 | Both Orthohepevirus A and Zika virus have been shown to downregulate a specific gene. Experimental data for this gene, derived from hepatocytes in study GSE135619, reports a log2 fold change of -1.845 and an adjusted p-value of 0.04032. Which disease is associated with this gene? | hyperplasia | Medium | convergence | {"qa_id":"medium_convergence_02211","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Zika virus have been shown to downregulate a specific gene. Experimental data for this gene, derived from hepatocytes in study GSE1... | |
medium_convergence_02212 | Measles morbillivirus and Cardiovirus A both upregulate a specific gene. Evidence for this shared target reports a log2 fold change of 1.361 and an adjusted p-value of 0.0236. Which protein is encoded by this gene? | LIM and cysteine-rich domains protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02212","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Measles morbillivirus and Cardiovirus A both upregulate a specific gene. Evidence for this shared target reports a log2 fold change of 1.361 and an adjusted ... | |
medium_convergence_02213 | GATA3 and IL17B are both associated with the regulation of specific type 2 cytokines. A study demonstrates that in the human immune system, IL-17B is functionally similar to IL-25 and elicits type 2 cytokine secretion from innate type 2 lymphocytes, NKT, and CD4+ CRTH2+ Th2 cells. Based on this evidence regarding IL-17... | interleukin-5 production | Medium | convergence | {"qa_id":"medium_convergence_02213","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GATA3 and IL17B are both associated with the regulation of specific type 2 cytokines. A study demonstrates that in the human immune system, IL-17B is functio... | |
medium_convergence_02215 | EGFR and ERBB3 both interact with a specific shared protein. Experimental evidence indicates that this protein coprecipitates with activated epidermal growth factor and platelet-derived growth factor (PDGF) receptors, and that phosphorylated tyrosine residues on the PDGF receptor mediate its tyrosine phosphorylation. W... | ovarian neoplasm | Medium | convergence | {"qa_id":"medium_convergence_02215","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and ERBB3 both interact with a specific shared protein. Experimental evidence indicates that this protein coprecipitates with activated epidermal growth... | |
medium_convergence_02216 | EP300 and FOXO1 share multiple binding partners. One shared partner is implicated in a mechanism where immunoprecipitation and DNA affinity protein binding assays revealed the association of c-Jun and p300 via this entity, alongside the dissociation of histone deacetylase 1 (HDAC1) via c-Jun recruitment to the CCAAT bo... | Nuclear transcription factor Y subunit alpha | Medium | convergence | {"qa_id":"medium_convergence_02216","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and FOXO1 share multiple binding partners. One shared partner is implicated in a mechanism where immunoprecipitation and DNA affinity protein binding a... | |
medium_convergence_02217 | BIRC2 and CD40 both interact with a specific shared protein. Experimental evidence indicates that while c-IAP1 binds to both TRAF2 and this shared protein in vitro, it only ubiquitinates TRAF2. Which protein is encoded by the gene corresponding to this shared entity? | TNF receptor-associated factor 1 | Medium | convergence | {"qa_id":"medium_convergence_02217","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC2 and CD40 both interact with a specific shared protein. Experimental evidence indicates that while c-IAP1 binds to both TRAF2 and this shared protein in... | |
medium_convergence_02218 | CDK8 and MED10 share multiple binding partners. One of these shared partners is described in the literature as physically linking the CDK8 module to the Mediator complex. Which disease is associated with this specific shared partner? | intellectual developmental disorder 61 | Medium | convergence | {"qa_id":"medium_convergence_02218","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK8 and MED10 share multiple binding partners. One of these shared partners is described in the literature as physically linking the CDK8 module to the Medi... | |
medium_convergence_02219 | CSNK2B and MAPK1 both interact with a shared protein. Experimental evidence indicates that ERK1 and ERK2 were detected in immunoprecipitates of RSK3 (and to a lesser extent, a related kinase), but were absent in RSK1 immunoprecipitates. Which protein is encoded by the gene corresponding to this shared entity? | Ribosomal protein S6 kinase alpha-3 | Medium | convergence | {"qa_id":"medium_convergence_02219","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2B and MAPK1 both interact with a shared protein. Experimental evidence indicates that ERK1 and ERK2 were detected in immunoprecipitates of RSK3 (and to ... | |
medium_convergence_02220 | TRIM28 and CDK7 share a common interaction partner. Evidence indicates that this shared partner interacts with TRIM28, and that TRIM28 protects this partner from proteasome-mediated degradation via physical protein-protein interaction to suppress colorectal cancer (CRC) metastasis. Which disease is associated with this... | melanoma | Medium | convergence | {"qa_id":"medium_convergence_02220","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and CDK7 share a common interaction partner. Evidence indicates that this shared partner interacts with TRIM28, and that TRIM28 protects this partner ... | |
medium_convergence_02221 | CREBBP and EP300 both interact with a shared protein. Evidence for one such shared partner states: 'In an unbiased search for potential coactivators of SREBP, we isolated a protein of 265 kD from HeLa cells that directly bound SREBP-1 and SREBP-2.' Which gene interacts with this specific shared partner? | UBE2I | Medium | convergence | {"qa_id":"medium_convergence_02221","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and EP300 both interact with a shared protein. Evidence for one such shared partner states: 'In an unbiased search for potential coactivators of SREBP... | |
medium_convergence_02222 | EGFR and ERBB2 each interact with more than one shared gene product. Evidence concerning one of these shared entities reports that CCh (100 microM) stimulated tyrosine phosphorylation and association of the Ca(2+)-dependent tyrosine kinase, PYK-2, with this entity, an effect that was inhibited by the Ca(2+) chelator, B... | nephritis | Medium | convergence | {"qa_id":"medium_convergence_02222","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and ERBB2 each interact with more than one shared gene product. Evidence concerning one of these shared entities reports that CCh (100 microM) stimulate... | |
medium_convergence_02223 | Erythromycin and Aprepitant both interact with a specific drug. Evidence regarding this shared interaction partner notes that there are pharmacological interactions between these drugs and other medications metabolized by the cytochrome P450 (CYP3A4 isoform), such as azole antifungals, the shared drug, and HIV protease... | erectile dysfunction | Medium | convergence | {"qa_id":"medium_convergence_02223","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Erythromycin and Aprepitant both interact with a specific drug. Evidence regarding this shared interaction partner notes that there are pharmacological inter... | |
medium_convergence_02224 | Both West Nile virus and Zika virus have been shown to downregulate the expression of a specific gene. Experimental data from monocyte-derived dendritic cells (study GSE136342) indicate that for one such shared target, the log2 fold change is approximately -1.022 and the adjusted p-value is 0.0007374. Which disease is ... | prostate cancer | Medium | convergence | {"qa_id":"medium_convergence_02224","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both West Nile virus and Zika virus have been shown to downregulate the expression of a specific gene. Experimental data from monocyte-derived dendritic cell... | |
medium_convergence_02225 | Both Zaire ebolavirus and Zika virus are reported to downregulate a specific gene. Experimental data from a study on retinal pigment epithelium cell lines (GSE100839) indicates that for one such shared target, the log2 fold change is approximately -1.798 and the adjusted p-value is 1.84e-07. Which protein is encoded by... | Interferon regulatory factor 2-binding protein 2 | Medium | convergence | {"qa_id":"medium_convergence_02225","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Zaire ebolavirus and Zika virus are reported to downregulate a specific gene. Experimental data from a study on retinal pigment epithelium cell lines (G... | |
medium_convergence_02226 | IRF3 and IKBKG both interact with a common protein adapter. Evidence indicates that phosphorylated forms of this adapter and STING bind to a positively charged surface of interferon regulatory factor 3 (IRF3), thereby recruiting IRF3 for its phosphorylation and activation by TBK1. Which protein is encoded by the gene c... | Mitochondrial antiviral-signaling protein | Medium | convergence | {"qa_id":"medium_convergence_02226","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IRF3 and IKBKG both interact with a common protein adapter. Evidence indicates that phosphorylated forms of this adapter and STING bind to a positively charg... | |
medium_convergence_02227 | FGF1 and FGF19 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'In solution, the extracellular domain of this receptor formed complexes with acidic FGF (FGF-1) and basic FGF (FGF-2), both in the presence and absence of heparin.' Which protein is encoded by th... | Fibroblast growth factor receptor 4 | Medium | convergence | {"qa_id":"medium_convergence_02227","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FGF1 and FGF19 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'In solution, the extracellular d... | |
medium_convergence_02228 | CDK9 and CEBPA share interaction partners. One such shared partner is an E3 ubiquitin ligase that associates with the CDK9 subunit of positive transcription elongation factor b to mediate its polyubiquitination in human cells. Which protein is encoded by this shared partner? | E3 ubiquitin-protein ligase UBR5 | Medium | convergence | {"qa_id":"medium_convergence_02228","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK9 and CEBPA share interaction partners. One such shared partner is an E3 ubiquitin ligase that associates with the CDK9 subunit of positive transcription ... | |
medium_convergence_02229 | Both Human betaherpesvirus 5 and Rhinovirus A are known to upregulate a specific shared gene. Experimental data for this gene in a retinal pigment epithelium cell line (study GSE120891) reports a log2 fold change of approximately 2.88 and an adjusted p-value of 0.00016. Which protein interacts with this upregulated gen... | NDN | Medium | convergence | {"qa_id":"medium_convergence_02229","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human betaherpesvirus 5 and Rhinovirus A are known to upregulate a specific shared gene. Experimental data for this gene in a retinal pigment epithelium... | |
medium_convergence_02230 | SIVA1 and HSPA8 both interact with a specific shared protein. Evidence regarding this shared partner states: 'Screening a human heart cDNA library revealed a yet unknown interaction partner of the proapoptotic protein Siva. We demonstrate that Siva specifically interacts with the heart and skeletal muscle protein [shar... | Z disc | Medium | convergence | {"qa_id":"medium_convergence_02230","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIVA1 and HSPA8 both interact with a specific shared protein. Evidence regarding this shared partner states: 'Screening a human heart cDNA library revealed a... | |
medium_convergence_02231 | ARCN1 and ARF4 both interact with a shared protein partner. Experimental evidence for this interaction includes immunoprecipitation and two-hybrid analysis within a complete COP screen, which demonstrated physical interactions between alpha- and epsilon-COPs, as well as between beta- and delta-COPs. Which protein is en... | Coatomer subunit beta | Medium | convergence | {"qa_id":"medium_convergence_02231","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARCN1 and ARF4 both interact with a shared protein partner. Experimental evidence for this interaction includes immunoprecipitation and two-hybrid analysis w... | |
medium_convergence_02232 | ERCC1 and FAAP100 both interact with a specific protein. Evidence indicates that this protein forms a conserved DNA-remodeling complex with the histone-fold heterodimer MHF. Which protein is encoded by the gene corresponding to this entity? | Fanconi anemia group M protein | Medium | convergence | {"qa_id":"medium_convergence_02232","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERCC1 and FAAP100 both interact with a specific protein. Evidence indicates that this protein forms a conserved DNA-remodeling complex with the histone-fold ... | |
medium_convergence_02234 | FBXW11 and HDAC2 both interact with a shared gene product. Evidence indicates that this specific shared entity is targeted for proteasome-dependent degradation by the SCF(βTrCP) ubiquitin ligase during the G2 phase of the cell division cycle. Which disease is causally linked to this entity? | quadriplegia | Medium | convergence | {"qa_id":"medium_convergence_02234","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FBXW11 and HDAC2 both interact with a shared gene product. Evidence indicates that this specific shared entity is targeted for proteasome-dependent degradati... | |
medium_convergence_02235 | CHEK2 and PPP2CB share multiple interacting partners. One such partner was identified in a yeast two-hybrid screen where Chk2 was found to associate with the B' regulatory subunit of protein phosphatase PP2A. Which biological process is this specific interacting partner involved in? | negative regulation of protein localization to plasma membrane | Medium | convergence | {"qa_id":"medium_convergence_02235","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK2 and PPP2CB share multiple interacting partners. One such partner was identified in a yeast two-hybrid screen where Chk2 was found to associate with the... | |
medium_convergence_02236 | KANSL1 and HCFC1 both physically interact with a specific shared protein partner. Evidence regarding this partner states: 'We also find that [REDACTED] is a component of additional complexes, forming associations with host cell factor 1 and a protein distantly related to MSL1 (hMSL1v1).' Which gene does this shared par... | BAZ1B | Medium | convergence | {"qa_id":"medium_convergence_02236","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KANSL1 and HCFC1 both physically interact with a specific shared protein partner. Evidence regarding this partner states: 'We also find that [REDACTED] is a ... | |
medium_convergence_02237 | HLA-A and B2M share a common interaction partner. Contextual evidence states: 'However, we show here that the inefficiency with which T134K presents intracellular antigen is associated with its inability to interact with the TAP heterodimer.' Which disease is linked to this shared interaction partner via a biomarker re... | glaucoma | Medium | convergence | {"qa_id":"medium_convergence_02237","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HLA-A and B2M share a common interaction partner. Contextual evidence states: 'However, we show here that the inefficiency with which T134K presents intracel... | |
medium_convergence_02238 | Primate erythroparvovirus 1 and Measles morbillivirus both upregulate a specific gene in erythroid progenitor cells. Experimental data for this shared target indicates a log2 fold change of approximately 3.13 and an adjusted p-value of 0.0357. Which protein is encoded by this gene? | C-X-C motif chemokine 11 | Medium | convergence | {"qa_id":"medium_convergence_02238","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Primate erythroparvovirus 1 and Measles morbillivirus both upregulate a specific gene in erythroid progenitor cells. Experimental data for this shared target... | |
medium_convergence_02239 | PARP1 and HDAC2 share a common interacting partner. Experimental evidence indicates that PARP1 is a novel interacting protein for this shared entity, specifically noting that the entity's PAR-binding zinc finger domain mediates interaction with poly-ADP ribosylated PARP1. Which protein is encoded by this shared interac... | E3 ubiquitin-protein ligase CHFR | Medium | convergence | {"qa_id":"medium_convergence_02239","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and HDAC2 share a common interacting partner. Experimental evidence indicates that PARP1 is a novel interacting protein for this shared entity, specifi... | |
medium_convergence_02240 | ANAPC15 and ANAPC11 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Both APC11 and UbcH10 bind to the C-terminal cullin homology domain of this shared partner, whereas Ubc4 interacts with APC11 directly.' Which cellular component is this shared partner locat... | anaphase-promoting complex | Medium | convergence | {"qa_id":"medium_convergence_02240","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC15 and ANAPC11 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Both APC11 and UbcH10 bind ... | |
medium_convergence_02241 | Reteplase and Tenecteplase both interact with a specific drug. Clinical evidence regarding this drug describes a protocol where patients receive half-dose reteplase and full-dose of the drug, followed by randomization to conventional medical therapy (with emergency rescue PTCA allowed in selected cases) or emergency an... | intermediate coronary syndrome | Medium | convergence | {"qa_id":"medium_convergence_02241","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Reteplase and Tenecteplase both interact with a specific drug. Clinical evidence regarding this drug describes a protocol where patients receive half-dose re... | |
medium_convergence_02242 | KDM1A and MYC share a common interacting partner. Evidence indicates that this shared partner functions as an adaptor molecule to recruit c-Myc to a complex containing BRCA1. Which protein is encoded by this shared interacting partner? | N-myc-interactor | Medium | convergence | {"qa_id":"medium_convergence_02242","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KDM1A and MYC share a common interacting partner. Evidence indicates that this shared partner functions as an adaptor molecule to recruit c-Myc to a complex ... | |
medium_convergence_02243 | DAXX and EED both interact with a specific protein. Evidence regarding this shared partner states: 'Here we describe the specific in vivo binding of Eed to Enx1 and Enx2, two mammalian homologs of the essential Drosophila Pc-G gene Enhancer-of-zeste [E(z)].' Which protein is encoded by the gene corresponding to this sh... | Histone-lysine N-methyltransferase EZH2 | Medium | convergence | {"qa_id":"medium_convergence_02243","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAXX and EED both interact with a specific protein. Evidence regarding this shared partner states: 'Here we describe the specific in vivo binding of Eed to E... | |
medium_convergence_02244 | ITCH and FADD both interact with a common protein. Evidence indicates that TAX1BP1 recruits the E3 ligase ITCH to this common protein to trigger its ubiquitination and degradation, and that loss of either TAX1BP1 or ITCH leads to increased expression of this common protein. Which protein is encoded by the gene correspo... | Mitochondrial antiviral-signaling protein | Medium | convergence | {"qa_id":"medium_convergence_02244","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ITCH and FADD both interact with a common protein. Evidence indicates that TAX1BP1 recruits the E3 ligase ITCH to this common protein to trigger its ubiquiti... | |
medium_convergence_02245 | HDAC1 and EBF2 share multiple binding partners. One such shared partner is reported to interact with NuRD proteins CHD4 and HDAC1, as well as the core cohesin complex protein RAD21, specifically within the ovary. Which disease is associated with this shared partner via a biomarker relationship? | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_02245","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and EBF2 share multiple binding partners. One such shared partner is reported to interact with NuRD proteins CHD4 and HDAC1, as well as the core cohesi... | |
medium_convergence_02246 | KCNA5 and KCNQ1 are both involved in more than one shared biological process. One shared process is characterized by the following evidence: 'In human heart, the Shaker-related voltage-gated K(+) channel KCNA5 alpha-subunit forms the major basis of an atrial-specific, ultra-rapid delayed rectifier K(+) current, I(Kur).... | cardiac muscle cell action potential involved in contraction | Medium | convergence | {"qa_id":"medium_convergence_02246","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KCNA5 and KCNQ1 are both involved in more than one shared biological process. One shared process is characterized by the following evidence: 'In human heart,... | |
medium_convergence_02247 | E2F3 and H3C1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here we examined the ability of Tax to interact with a histone methyltransferase that methylates histone H3 lysine 9 (H3K9) and represses transcription of genes, and studied the functional effects of the inter... | Histone-lysine N-methyltransferase SUV39H1 | Medium | convergence | {"qa_id":"medium_convergence_02247","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"E2F3 and H3C1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here we examined the ability of Tax to interac... | |
medium_convergence_02248 | ERBB4 and NRG1 share multiple binding partners. One such partner is described in evidence stating: 'Like NRG-1, the EGF-like domain of the new ligands binds to both the ErbB3- and the ErbB4-receptor tyrosine kinases.' Which disease is associated with this specific shared binding partner? | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_02248","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB4 and NRG1 share multiple binding partners. One such partner is described in evidence stating: 'Like NRG-1, the EGF-like domain of the new ligands binds ... | |
medium_convergence_02249 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific shared gene. Evidence for this gene in a monocytic leukemia cell line reports a log2 fold change of approximately 1.39 and an adjusted p-value of approximately 0.0028. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_02249","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific shared gene. Evidence for this gene in a monocytic leukemia cell line reports... | |
medium_convergence_02250 | Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experimental data from a melanoma cell line (study GSE136586) indicates that this gene exhibits a log2 fold change of approximately -1.278 and an adjusted p-value of 6.018e-... | Ubiquitin-associated and SH3 domain-containing protein B | Medium | convergence | {"qa_id":"medium_convergence_02250","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experiment... | |
medium_convergence_02251 | CBX3 and EHMT1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Automethylation of the protein encoded by this partner at ARKT motif creates a binding site for HP1 class of protein and mutation of lysine in the motif impairs this binding.' Which protein ... | Histone-lysine N-methyltransferase EHMT2 | Medium | convergence | {"qa_id":"medium_convergence_02251","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX3 and EHMT1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Automethylation of the prot... | |
medium_convergence_02254 | YAP1 and CYLD share multiple protein interaction partners. One such shared partner has been experimentally shown to directly interact with YAP1 via a WB motif-WW domain interaction. Which protein is encoded by the gene corresponding to this shared partner? | Poly(rC)-binding protein 2 | Medium | convergence | {"qa_id":"medium_convergence_02254","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and CYLD share multiple protein interaction partners. One such shared partner has been experimentally shown to directly interact with YAP1 via a WB moti... | |
medium_convergence_02255 | STUB1 and MID2 both interact with a shared protein. Contextual evidence highlights that CHIP functions as a partner of a specific E2 ubiquitin-conjugating enzyme in the formation of Lys63-linked polyubiquitin chains, thereby extending CHIP's role into ubiquitin regulation. Which protein, encoded by the gene connected t... | Ubiquitin-conjugating enzyme E2 N | Medium | convergence | {"qa_id":"medium_convergence_02255","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and MID2 both interact with a shared protein. Contextual evidence highlights that CHIP functions as a partner of a specific E2 ubiquitin-conjugating en... | |
medium_convergence_02256 | STRA13 and FANCA share common binding partners. One such shared partner is characterized by the following evidence: 'Here, we demonstrate that the WD40 repeats of this protein are required for interaction with other subunits of the FA complex.' Which gene interacts with this specific shared partner? | UBE2W | Medium | convergence | {"qa_id":"medium_convergence_02256","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STRA13 and FANCA share common binding partners. One such shared partner is characterized by the following evidence: 'Here, we demonstrate that the WD40 repea... | |
medium_convergence_02257 | OPTN and CDC37 share multiple interacting partners. One such partner is identified in the following evidence: 'Here, we identified optineurin (OPTN) as an [entity]-binding protein by yeast two-hybrid screening using [entity] as bait.' Which cell type is enriched for this specific interacting entity? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_02257","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"OPTN and CDC37 share multiple interacting partners. One such partner is identified in the following evidence: 'Here, we identified optineurin (OPTN) as an [e... | |
medium_convergence_02258 | Vaccinia virus and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately 1.856 and an adjusted p-value of 7.891e-05. Which protein does this gene product interact with? | PHB1 | Medium | convergence | {"qa_id":"medium_convergence_02258","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) rep... | |
medium_convergence_02259 | Both Measles morbillivirus and Influenza A virus are known to downregulate a specific shared gene. Experimental data for this gene indicates a log2 fold change of approximately -1.117 and an adjusted p-value of 0.01331. Which cell type is this gene enriched in? | regulatory T cell | Medium | convergence | {"qa_id":"medium_convergence_02259","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Influenza A virus are known to downregulate a specific shared gene. Experimental data for this gene indicates a log2 fold chan... | |
medium_convergence_02260 | Measles morbillivirus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in pleural mesothelioma cells (study GSE117668) shows a log2 fold change of approximately -1.041 and an adjusted p-value of 0.01169. Which protein is encoded by this gene? | C-C motif chemokine 2 | Medium | convergence | {"qa_id":"medium_convergence_02260","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Measles morbillivirus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in pleural mesothelioma cells (study GSE117668) sho... | |
medium_convergence_02261 | IFITM3 and KHDRBS1 both interact with a specific protein. Evidence indicates that tr-kit promotes the association of Sam68 with PLCgamma1 and this specific protein in a multimolecular complex, as demonstrated by co-immunoprecipitation of the phosphorylated forms of these proteins using antibodies directed to any of the... | Tyrosine-protein kinase Fyn | Medium | convergence | {"qa_id":"medium_convergence_02261","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IFITM3 and KHDRBS1 both interact with a specific protein. Evidence indicates that tr-kit promotes the association of Sam68 with PLCgamma1 and this specific p... | |
medium_convergence_02262 | EPS15 and CBL both interact with a specific protein. Contextual evidence highlights that Sprouty2 tyrosine phosphorylation is necessary for its binding to the Src homology 2-like domain of c-Cbl after fibroblast growth factor (FGF) stimulation, and notes that Sprouty1 interacts with c-Cbl/Cbl-b in TCR signalosomes. Whi... | Protein sprouty homolog 1 | Medium | convergence | {"qa_id":"medium_convergence_02262","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EPS15 and CBL both interact with a specific protein. Contextual evidence highlights that Sprouty2 tyrosine phosphorylation is necessary for its binding to th... | |
medium_convergence_02263 | Vaccinia virus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of -1.064 and an adjusted p-value of 0.04669. Which cellular component is this gene located in? | mitochondrion | Medium | convergence | {"qa_id":"medium_convergence_02263","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) re... | |
medium_convergence_02264 | ESR1 and PML share a common interacting partner. Evidence regarding this partner states: 'Utilizing an interaction blocker, ER-6 (amino acids 312-340), responsible for the interaction with this partner, the suppression of ER by this partner could be reversed, suggesting that this suppression is conferred by the direct ... | negative regulation of transcription by RNA polymerase II | Medium | convergence | {"qa_id":"medium_convergence_02264","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and PML share a common interacting partner. Evidence regarding this partner states: 'Utilizing an interaction blocker, ER-6 (amino acids 312-340), respo... | |
medium_convergence_02265 | Both Measles morbillivirus and Dengue virus are associated with the downregulation of a specific gene. Experimental data for this gene from study GSE131840 indicates a log2 fold change of approximately -1.502 and an adjusted p-value of 0.0007391. What protein is encoded by this gene? | Ganglioside GM2 activator | Medium | convergence | {"qa_id":"medium_convergence_02265","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Dengue virus are associated with the downregulation of a specific gene. Experimental data for this gene from study GSE131840 i... | |
medium_convergence_02266 | ELANE and MPO are both located in more than one shared cellular component. Evidence concerning one of these shared components reports that MPO was detected in large azurophil granules. Which cell type is connected to that specific component via the 'absent from cell' relationship? | myeloblast | Medium | convergence | {"qa_id":"medium_convergence_02266","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ELANE and MPO are both located in more than one shared cellular component. Evidence concerning one of these shared components reports that MPO was detected i... | |
medium_convergence_02267 | BOP1 and LAS1L both interact with a specific shared protein. Experimental evidence indicates that mutant M1 and M5 proteins, which are associated with large pre-ribosomal complexes, co-immunoprecipitate this shared protein along with WDR12, demonstrating their proper incorporation into the PeBoW complex. Which protein ... | Pescadillo homolog | Medium | convergence | {"qa_id":"medium_convergence_02267","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BOP1 and LAS1L both interact with a specific shared protein. Experimental evidence indicates that mutant M1 and M5 proteins, which are associated with large ... | |
medium_convergence_02268 | Vaccinia virus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -1.044 and an adjusted p-value of 0.02825. Which cellular component is this gene located in? | endoplasmic reticulum | Medium | convergence | {"qa_id":"medium_convergence_02268","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) re... | |
medium_convergence_02270 | Both 'positive regulation of actin filament bundle assembly' and 'positive regulation of cardiac myofibril assembly' are subtypes of a shared biological process. Evidence for one such shared process states: 'Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles.... | supramolecular fiber organization | Medium | convergence | {"qa_id":"medium_convergence_02270","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both 'positive regulation of actin filament bundle assembly' and 'positive regulation of cardiac myofibril assembly' are subtypes of a shared biological proc... | |
medium_convergence_02272 | G3BP1 and MDM2 share interaction partners. One such shared partner is distinguished by evidence that its N-terminal region (or that of RPS27) binds to the central acidic domain of MDM2. Which protein is encoded by this specific shared interaction partner? | Ribosomal protein eS27-like | Medium | convergence | {"qa_id":"medium_convergence_02272","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"G3BP1 and MDM2 share interaction partners. One such shared partner is distinguished by evidence that its N-terminal region (or that of RPS27) binds to the ce... | |
medium_convergence_02273 | NEDD8 and ELOC both interact with a shared protein entity. Evidence from immunoprecipitation studies indicates that Elongin C and Cullin-5, components of the multi-subunit E3 ubiquitin ligase, bind to iNOS via this shared entity (along with other related proteins). Which protein is encoded by this shared entity? | SPRY domain-containing SOCS box protein 2 | Medium | convergence | {"qa_id":"medium_convergence_02273","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD8 and ELOC both interact with a shared protein entity. Evidence from immunoprecipitation studies indicates that Elongin C and Cullin-5, components of the... | |
medium_convergence_02274 | LGR6 and LGR5 share binding partners. For one such shared partner, evidence indicates that the monovalent form of its furin domain exhibits significantly lower binding affinity to LGR4 or RNF43/ZNRF3 compared to the bivalent form. In contrast, the monovalent and bivalent forms of this partner show nearly identical bind... | R-spondin-2 | Medium | convergence | {"qa_id":"medium_convergence_02274","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LGR6 and LGR5 share binding partners. For one such shared partner, evidence indicates that the monovalent form of its furin domain exhibits significantly low... | |
medium_convergence_02275 | CREBBP and FOXG1 both interact with a shared protein target. Evidence regarding one such target states: 'We provide evidence that the acetyltransferase CREB-binding protein (CBP) binds FOXO resulting in acetylation of FOXO.' Which protein is encoded by the gene corresponding to this shared target? | Forkhead box protein O4 | Medium | convergence | {"qa_id":"medium_convergence_02275","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and FOXG1 both interact with a shared protein target. Evidence regarding one such target states: 'We provide evidence that the acetyltransferase CREB-... | |
medium_convergence_02276 | CHEK2 and H2AX both interact with a common protein. Evidence indicates that this shared protein and SMURF2 act as a stabilizer and destabilizer of H2AX, respectively, through their dynamic interactions with H2AX. Which protein is encoded by the gene corresponding to this shared entity? | E3 ubiquitin-protein ligase RNF168 | Medium | convergence | {"qa_id":"medium_convergence_02276","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK2 and H2AX both interact with a common protein. Evidence indicates that this shared protein and SMURF2 act as a stabilizer and destabilizer of H2AX, resp... | |
medium_convergence_02277 | PPP1CA and BMP2 share multiple binding partners. One such partner is a gene that binds to protein phosphatase PP1 and attenuates translational elongation of key transcriptional factors through dephosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha). Which protein is connected to this gene through the 'enco... | Protein phosphatase 1 regulatory subunit 15A | Medium | convergence | {"qa_id":"medium_convergence_02277","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PPP1CA and BMP2 share multiple binding partners. One such partner is a gene that binds to protein phosphatase PP1 and attenuates translational elongation of ... | |
medium_convergence_02278 | EIF3E and EIF2S2 both interact with a shared protein partner. Evidence regarding one such partner states: 'A direct protein-protein interaction occurs between the protein encoded by the gene corresponding to this shared partner and Int-6, but the analysis of different mutants of the protein encoded by the gene correspo... | Eukaryotic translation initiation factor 3 subunit L | Medium | convergence | {"qa_id":"medium_convergence_02278","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3E and EIF2S2 both interact with a shared protein partner. Evidence regarding one such partner states: 'A direct protein-protein interaction occurs betwee... | |
medium_convergence_02279 | COMMD1 and CUL1 both interact with a shared protein partner. Evidence for one such partner states: 'This is validated by co-immunoprecipitation experiments from cells expressing the mutant protein and from human heart tissue from two of the affected patients.' Which disease is associated with this specific protein part... | gastric cancer | Medium | convergence | {"qa_id":"medium_convergence_02279","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COMMD1 and CUL1 both interact with a shared protein partner. Evidence for one such partner states: 'This is validated by co-immunoprecipitation experiments f... | |
medium_convergence_02280 | NEDD8 and PSMA4 both interact with a common protein partner. Evidence regarding this shared partner states: 'In the present study, we demonstrate that the 20S proteasome subunits alpha4 and alpha7 interact with each other as well as all the alpha-subunits in vivo and in vitro.' Which protein is encoded by this shared p... | Proteasome subunit alpha type-5 | Medium | convergence | {"qa_id":"medium_convergence_02280","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD8 and PSMA4 both interact with a common protein partner. Evidence regarding this shared partner states: 'In the present study, we demonstrate that the 20... | |
medium_convergence_02281 | YWHAQ and SFN share multiple interaction partners. One such partner is characterized by evidence stating: 'The nuclear-to-cytoplasmic translocation was mediated by phosphorylation-dependent [entity] binding to 14-3-3theta but not 14-3-3beta or -sigma.' Which cellular component is this entity located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_02281","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAQ and SFN share multiple interaction partners. One such partner is characterized by evidence stating: 'The nuclear-to-cytoplasmic translocation was media... | |
medium_convergence_02282 | DAB2 and DVL1 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Using a small-pool cDNA screening strategy, we identify that the N-terminal domain of Dab2 interacts with Dishevelled-3 (Dvl-3), a signaling mediator of the Wnt pathway.' Which protein is connected to tha... | Segment polarity protein dishevelled homolog DVL-3 | Medium | convergence | {"qa_id":"medium_convergence_02282","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAB2 and DVL1 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Using a small-pool cDNA screening strateg... | |
medium_convergence_02283 | FYN and GRB2 both interact with a specific protein. Evidence regarding this protein states: 'We have previously shown that GRB2 binds to P.Tyr789 in vivo and in vitro via its SH2 domain.' Which disease is associated with this protein through genomic alterations? | Parkinson disease | Medium | convergence | {"qa_id":"medium_convergence_02283","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FYN and GRB2 both interact with a specific protein. Evidence regarding this protein states: 'We have previously shown that GRB2 binds to P.Tyr789 in vivo and... | |
medium_convergence_02284 | KAT5 and ACTL6A both interact with a shared protein. Evidence indicates that this shared protein is encoded by a specific ORF and was designated as a new component of the TRRAP/TIP60 HAT complex. Which protein product is encoded by this gene? | MRG/MORF4L-binding protein | Medium | convergence | {"qa_id":"medium_convergence_02284","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KAT5 and ACTL6A both interact with a shared protein. Evidence indicates that this shared protein is encoded by a specific ORF and was designated as a new com... | |
medium_convergence_02285 | GNA15 and GNAI2 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'In vitro binding assays reveal that this protein and RGS16 bind to Galphai and Galphao subunits of heterotrimeric G-proteins, but not to Galphas.' Which protein is encoded by that shared partner... | Regulator of G-protein signaling 5 | Medium | convergence | {"qa_id":"medium_convergence_02285","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNA15 and GNAI2 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'In vitro binding assays reveal ... | |
medium_convergence_02286 | TRIM28 and GSK3B share a common interaction partner. Evidence regarding this shared entity states: 'Based on their function as known transcriptional regulators, a selection of the Mf2 domain-binding proteins (NPM1, TRIM28, and YB-1) have been validated using in vitro and cell-based assays.' Which protein is connected t... | Interferon regulatory factor 1 | Medium | convergence | {"qa_id":"medium_convergence_02286","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and GSK3B share a common interaction partner. Evidence regarding this shared entity states: 'Based on their function as known transcriptional regulato... | |
medium_convergence_02287 | EGFR and HRAS both interact with a specific shared protein. Evidence indicates that in Grade IV tumors, this protein (integrin-β1) shows higher expression and greater heteroassociation with ErbB1 compared to Grade II tumors. Which disease is associated with this shared protein? | hyperthyroidism | Medium | convergence | {"qa_id":"medium_convergence_02287","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and HRAS both interact with a specific shared protein. Evidence indicates that in Grade IV tumors, this protein (integrin-β1) shows higher expression an... | |
medium_convergence_02288 | Both Human orthopneumovirus and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental data from cytotoxic T-lymphocytes (study GSE106475) indicate that this gene exhibits a log2 fold change of approximately 1.804 and an adjusted p-value of 0.0309. Wh... | Nuclear protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02288","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human orthopneumovirus and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental d... | |
medium_convergence_02289 | SMAD3 and SMAD7 both interact with a specific shared protein partner. Experimental evidence indicates that this shared partner physically interacts with the HMG box domain of the partner protein itself (or its binding partner in the complex). Which protein is encoded by the gene corresponding to this shared partner? | Lymphoid enhancer-binding factor 1 | Medium | convergence | {"qa_id":"medium_convergence_02289","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD3 and SMAD7 both interact with a specific shared protein partner. Experimental evidence indicates that this shared partner physically interacts with the ... | |
medium_convergence_02290 | Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data from a study on lung fibroblast cell lines (GSE120891) indicates that this gene exhibits a log2 fold change of approximately 3.147 and an adjusted p-value of approximat... | TCP1 | Medium | convergence | {"qa_id":"medium_convergence_02290","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data from ... | |
medium_convergence_02291 | CTSS and HSPA8 both interact with a shared protein. Evidence regarding this shared protein states: 'Like other Hsp40 proteins, ABBP-2 binds to Hsp70 and has ATPase-stimulating activity.' Which protein is encoded by the gene corresponding to this shared entity? | DnaJ homolog subfamily B member 11 | Medium | convergence | {"qa_id":"medium_convergence_02291","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTSS and HSPA8 both interact with a shared protein. Evidence regarding this shared protein states: 'Like other Hsp40 proteins, ABBP-2 binds to Hsp70 and has ... | |
medium_convergence_02292 | CDKN1A and PRMT1 both interact with a shared protein. Evidence indicates that Rapamycin induces p21(Cip1) binding to this shared protein, thereby suppressing kinase activity and attenuating cellular stress. Which protein is encoded by the gene corresponding to this shared entity? | Mitogen-activated protein kinase kinase kinase 5 | Medium | convergence | {"qa_id":"medium_convergence_02292","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDKN1A and PRMT1 both interact with a shared protein. Evidence indicates that Rapamycin induces p21(Cip1) binding to this shared protein, thereby suppressing... | |
medium_convergence_02293 | EP300 and FOXG1 both interact with a shared transcription factor. Evidence regarding this shared entity states: 'In this report, we show that the coactivator p300 directly acetylates lysines in the carboxyl-terminal region of this transcription factor in vivo and in vitro, and potently stimulates its induced transcript... | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | convergence | {"qa_id":"medium_convergence_02293","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and FOXG1 both interact with a shared transcription factor. Evidence regarding this shared entity states: 'In this report, we show that the coactivator... | |
medium_convergence_02294 | Dronabinol and Phentolamine both interact with a specific shared drug. Evidence regarding this shared drug states: 'The contractile effect of the drug was clearly antagonized by rauwolscine 10(-6) M, yohimbine 10(-6) M and phentolamine 3 X 10(-6) M plus propranolol 10(-5) M.' Which disease is this shared drug indicated... | malignant hypertension | Medium | convergence | {"qa_id":"medium_convergence_02294","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dronabinol and Phentolamine both interact with a specific shared drug. Evidence regarding this shared drug states: 'The contractile effect of the drug was cl... | |
medium_convergence_02295 | Rhinovirus A and Human gammaherpesvirus 8 both downregulate a specific gene. Experimental data from cytotoxic T-lymphocytes (study GSE106475) indicates that this gene has a log2 fold change of -3.834 and an adjusted p-value of 0.004312. Which protein is encoded by this gene? | Interleukin-1 receptor antagonist protein | Medium | convergence | {"qa_id":"medium_convergence_02295","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Human gammaherpesvirus 8 both downregulate a specific gene. Experimental data from cytotoxic T-lymphocytes (study GSE106475) indicates that ... | |
medium_convergence_02296 | PDCD6IP and DNM1 share multiple interacting partners. One such shared partner is characterized by evidence stating that its SH3 domains bind to the proline-rich region of dynamin. Which protein is encoded by this shared interacting partner? | Growth factor receptor-bound protein 2 | Medium | convergence | {"qa_id":"medium_convergence_02296","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PDCD6IP and DNM1 share multiple interacting partners. One such shared partner is characterized by evidence stating that its SH3 domains bind to the proline-r... | |
medium_convergence_02297 | EGFR and SYK share common interacting partners. One such shared partner is involved in a process where a specific E3 ubiquitin ligase is recruited to EGFRvIII, thereby inhibiting the transformation of NIH 3T3 cells by EGFRvIII. Which protein is encoded by the gene corresponding to this shared interacting partner? | E3 ubiquitin-protein ligase CBL-B | Medium | convergence | {"qa_id":"medium_convergence_02297","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and SYK share common interacting partners. One such shared partner is involved in a process where a specific E3 ubiquitin ligase is recruited to EGFRvII... | |
medium_convergence_02298 | ATM and NFIX share multiple interacting partners. One such shared partner is reported to associate with a zinc finger protein in an HDACi-dependent manner, as revealed by co-immunoprecipitation. Which protein is encoded by this shared partner? | Zinc finger protein 148 | Medium | convergence | {"qa_id":"medium_convergence_02298","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATM and NFIX share multiple interacting partners. One such shared partner is reported to associate with a zinc finger protein in an HDACi-dependent manner, a... | |
medium_convergence_02299 | FANCB and BRCA2 both interact with a specific shared protein. Evidence indicates that monoubiquitination of this protein, a process activated by DNA damage, is required for its targeting to chromatin, where it subsequently interacts with BRCA2. Which protein is encoded by the gene corresponding to this shared entity? | Fanconi anemia group D2 protein | Medium | convergence | {"qa_id":"medium_convergence_02299","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCB and BRCA2 both interact with a specific shared protein. Evidence indicates that monoubiquitination of this protein, a process activated by DNA damage, ... | |
medium_convergence_02300 | SNF8 and TSG101 both bind to a shared protein. Evidence regarding this shared protein states: 'The ability of HCRP1 (which we assign the alternative name hVps37A) to interact with Tsg101 is conferred by its mod(r) domain and is shared with hVps37B and hVps37C, two other mod(r) domain-containing proteins.' Which gene in... | HGS | Medium | convergence | {"qa_id":"medium_convergence_02300","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SNF8 and TSG101 both bind to a shared protein. Evidence regarding this shared protein states: 'The ability of HCRP1 (which we assign the alternative name hVp... | |
medium_convergence_02301 | ATR and BRCA1 both interact with a specific protein. Evidence indicates that this protein interacts in vitro and in vivo with BRCA1 and forms a complex with hMre11 and p95/nibrin. Which cell type is this protein enriched in? | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_02301","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATR and BRCA1 both interact with a specific protein. Evidence indicates that this protein interacts in vitro and in vivo with BRCA1 and forms a complex with ... | |
medium_convergence_02302 | E2F5 and HDAC1 both interact with a specific shared protein partner. Experimental evidence indicates that under physiological conditions, E2F-5 interacts preferentially with this partner. Which protein is encoded by the gene corresponding to this shared partner? | Retinoblastoma-like protein 2 | Medium | convergence | {"qa_id":"medium_convergence_02302","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"E2F5 and HDAC1 both interact with a specific shared protein partner. Experimental evidence indicates that under physiological conditions, E2F-5 interacts pre... | |
medium_convergence_02303 | CDK2 and PARP1 both interact with a specific gene product. Evidence indicates that Cyclin A-Cdk2 and Cyclin E-Cdk2 complexes phosphorylate this entity in a cell-free system on the same sites as in intact cells. Which cell type is this entity enriched in? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_02303","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and PARP1 both interact with a specific gene product. Evidence indicates that Cyclin A-Cdk2 and Cyclin E-Cdk2 complexes phosphorylate this entity in a c... |
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