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medium_convergence_02747 | SMURF1 and TP53 share a common interacting partner. Evidence regarding one such partner states: 'We determined that LMP-1, a LIM domain protein capable of inducing de novo bone formation, interacts with Smurf1 (Smad ubiquitin regulatory factor 1) and prevents ubiquitination of Smads.' Which protein is encoded by the ge... | PDZ and LIM domain protein 7 | Medium | convergence | {"qa_id":"medium_convergence_02747","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMURF1 and TP53 share a common interacting partner. Evidence regarding one such partner states: 'We determined that LMP-1, a LIM domain protein capable of in... | |
medium_convergence_02748 | CLTB and CLTC each interact with more than one shared gene. Evidence concerning one shared entity reports: 'The presence of the α2-linker structurally defines a new clathrin-binding domain that is unique to this motor protein(long) and masks the known RRL interaction motif.' Which disease is connected to that entity th... | retinal degeneration | Medium | convergence | {"qa_id":"medium_convergence_02748","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CLTB and CLTC each interact with more than one shared gene. Evidence concerning one shared entity reports: 'The presence of the α2-linker structurally define... | |
medium_convergence_02749 | CDK2 and CKS1B both interact with a specific shared protein. Experimental evidence indicates that both the N-terminal and C-terminal regions of this shared protein are involved in binding to cyclin A. Which protein is encoded by the gene corresponding to this shared entity? | S-phase kinase-associated protein 2 | Medium | convergence | {"qa_id":"medium_convergence_02749","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and CKS1B both interact with a specific shared protein. Experimental evidence indicates that both the N-terminal and C-terminal regions of this shared p... | |
medium_convergence_02750 | RRAGA and MLST8 each interact with more than one shared protein partner. Evidence concerning one such shared partner indicates that Rag A associates with both Rag C and Rag D in their C-terminal regions, where a potential leucine zipper motif and a coiled-coil structure were identified. Which protein corresponds to thi... | Ras-related GTP-binding protein D | Medium | convergence | {"qa_id":"medium_convergence_02750","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RRAGA and MLST8 each interact with more than one shared protein partner. Evidence concerning one such shared partner indicates that Rag A associates with bot... | |
medium_convergence_02751 | Human polyomavirus 1 and Zika virus both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) reports a log2 fold change of approximately 1.616 and an adjusted p-value of 0.01905. Which protein does this gene product interact with? | SLC2A1 | Medium | convergence | {"qa_id":"medium_convergence_02751","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Zika virus both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) reports a lo... | |
medium_convergence_02753 | HES1 and LEF1 each interact with more than one shared partner. Evidence concerning one shared entity reports that the L743F mutation selectively blocks binding to Hes1, an anti-neurogenic basic helix-loop-helix protein that harbors a WRPW motif. Which disease is connected to that entity through association? | fibrosarcoma | Medium | convergence | {"qa_id":"medium_convergence_02753","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HES1 and LEF1 each interact with more than one shared partner. Evidence concerning one shared entity reports that the L743F mutation selectively blocks bindi... | |
medium_convergence_02754 | ESR1 and H2AFZ share common interaction partners. One such partner is described by the evidence: 'The core SWI/SNF subunit [protein encoded by SMARCE1] mediates direct interactions with estrogen and androgen receptors (ER and AR) regulating their transcriptional activity.' Which protein is encoded by the gene correspon... | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 | Medium | convergence | {"qa_id":"medium_convergence_02754","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and H2AFZ share common interaction partners. One such partner is described by the evidence: 'The core SWI/SNF subunit [protein encoded by SMARCE1] media... | |
medium_convergence_02756 | CENPA and CENPO each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Here, we purified non-nucleosomal CENP-A complexes to identify direct CENP-A partners involved in such a mechanism and identified this protein.' Which protein is encoded by that entity? | Holliday junction recognition protein | Medium | convergence | {"qa_id":"medium_convergence_02756","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPA and CENPO each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Here, we purified non-nucleosoma... | |
medium_convergence_02757 | LSM1 and LSM3 each interact with multiple shared partners. Evidence concerning one such shared partner indicates that a mutant protein lacking the RGG domain failed to rescue processing body (PB) formation in cells depleted of the endogenous protein, although this mutant retained the ability to assemble with the LSM1-7... | U6 snRNA-associated Sm-like protein LSm4 | Medium | convergence | {"qa_id":"medium_convergence_02757","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LSM1 and LSM3 each interact with multiple shared partners. Evidence concerning one such shared partner indicates that a mutant protein lacking the RGG domain... | |
medium_convergence_02758 | STK38 and IGF1R share multiple interacting partners. One such partner is identified by evidence stating that both MDM2 and beta-arrestin co-immunoprecipitated with IGF-1R. Which cell type is enriched for this specific interacting partner? | non-classical monocyte | Medium | convergence | {"qa_id":"medium_convergence_02758","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STK38 and IGF1R share multiple interacting partners. One such partner is identified by evidence stating that both MDM2 and beta-arrestin co-immunoprecipitate... | |
medium_convergence_02759 | HSP90AA1 and MAP3K7 share common interaction partners. One such partner is described in evidence stating: 'Functional inhibition of Hsp90 by the anti-tumor agent geldanamycin (GA) efficiently disrupts its interaction with this partner, resulting in its degradation and subsequent blockage of p100 processing.' Which dise... | diabetes mellitus | Medium | convergence | {"qa_id":"medium_convergence_02759","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSP90AA1 and MAP3K7 share common interaction partners. One such partner is described in evidence stating: 'Functional inhibition of Hsp90 by the anti-tumor a... | |
medium_convergence_02760 | SIN3A and NPM1 share common interaction partners. One such partner is supported by evidence showing that a proliferation-associated protein interacts with it both in vitro and in vivo, as demonstrated by glutathione S-transferase (GST) pull-down and coimmunoprecipitation analysis. Which protein is encoded by this share... | Proliferation-associated protein 2G4 | Medium | convergence | {"qa_id":"medium_convergence_02760","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIN3A and NPM1 share common interaction partners. One such partner is supported by evidence showing that a proliferation-associated protein interacts with it... | |
medium_convergence_02761 | HDAC6 and CSNK2A1 both interact with a specific shared protein. Evidence indicates that in unstressed cells, this shared protein interacts with H2A/H2A.X to prevent its interaction with the E3 ligase RNF168. Which protein is encoded by the gene corresponding to this shared entity? | Histone H2AX | Medium | convergence | {"qa_id":"medium_convergence_02761","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC6 and CSNK2A1 both interact with a specific shared protein. Evidence indicates that in unstressed cells, this shared protein interacts with H2A/H2A.X to ... | |
medium_convergence_02762 | NBN and TP53 share multiple interacting partners. One of these shared partners is reported to form a basal preassembled complex with NBS1 in non-damaged cells. Which protein is encoded by this specific shared partner? | Serine/threonine-protein kinase VRK1 | Medium | convergence | {"qa_id":"medium_convergence_02762","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NBN and TP53 share multiple interacting partners. One of these shared partners is reported to form a basal preassembled complex with NBS1 in non-damaged cell... | |
medium_convergence_02763 | IKZF1 and CBX1 both interact with a specific chromatin remodeling protein. Evidence regarding this protein states that repression is mediated through two independent domains at the N and C terminus, both of which can independently recruit the corepressors Mi-2beta, Sin3A, and Sin3B and the Class I histone deacetylases ... | ATP-dependent chromatin remodeler CHD4 | Medium | convergence | {"qa_id":"medium_convergence_02763","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IKZF1 and CBX1 both interact with a specific chromatin remodeling protein. Evidence regarding this protein states that repression is mediated through two ind... | |
medium_convergence_02764 | BBC3 and CASP3 are both involved in more than one shared biological process. Evidence indicates that Caspase-3-deficient parental MCF7 cells failed to undergo morphological nuclear and DNA fragmentation, whereas MCF7 cells expressing CASP3 displayed intact nuclear dismantling and DNA fragmentation. Which biological pro... | cellular process | Medium | convergence | {"qa_id":"medium_convergence_02764","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BBC3 and CASP3 are both involved in more than one shared biological process. Evidence indicates that Caspase-3-deficient parental MCF7 cells failed to underg... | |
medium_convergence_02765 | RAD50 and BRCC3 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that Abraxas and this partner associate through coiled-coil domains on each protein. Which protein is encoded by the gene corresponding to this shared partner? | BRCA1-A complex subunit RAP80 | Medium | convergence | {"qa_id":"medium_convergence_02765","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAD50 and BRCC3 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that Abraxas and this par... | |
medium_convergence_02768 | LGR6 and LGR5 both interact with a shared protein partner. Evidence regarding one of these partners describes the structure of a low-resolution hLGR5-mRspo2Fu1-Fu2-m[Partner]ecto ternary complex. Which cellular component is this specific partner located in? | plasma membrane | Medium | convergence | {"qa_id":"medium_convergence_02768","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LGR6 and LGR5 both interact with a shared protein partner. Evidence regarding one of these partners describes the structure of a low-resolution hLGR5-mRspo2F... | |
medium_convergence_02769 | TOPBP1 and INTS6 both interact with a shared protein. Evidence regarding this shared protein states: 'In this report, we investigated the functional significance of the interaction between INT6 and the shared protein, which was observed in a two-hybrid screen performed with INT6 as bait.' Which protein is encoded by th... | DNA replication licensing factor MCM7 | Medium | convergence | {"qa_id":"medium_convergence_02769","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TOPBP1 and INTS6 both interact with a shared protein. Evidence regarding this shared protein states: 'In this report, we investigated the functional signific... | |
medium_convergence_02770 | Morphine and Dronabinol both interact with a specific drug. Clinical evidence regarding this drug indicates that in the treatment group, cumulative morphine consumption from 0 to 48 hours postoperatively was lower (11 mg [5 to 21] versus 6 mg [0 to 17]) and the incidence of postoperative nausea and vomiting was reduced... | anxiety | Medium | convergence | {"qa_id":"medium_convergence_02770","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Morphine and Dronabinol both interact with a specific drug. Clinical evidence regarding this drug indicates that in the treatment group, cumulative morphine ... | |
medium_convergence_02771 | APOE and ADTRP are both associated with multiple shared biological processes. One such shared process is supported by evidence stating: 'We conclude that apoE inhibits platelet aggregation through the L-arginine:NO signal transduction pathway.' Which biological process, connected to this shared regulatory function via ... | blood coagulation | Medium | convergence | {"qa_id":"medium_convergence_02771","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"APOE and ADTRP are both associated with multiple shared biological processes. One such shared process is supported by evidence stating: 'We conclude that apo... | |
medium_convergence_02772 | ATM and CASP10 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'We show that [the regulatory subunit of IkappaB kinase (IKK)], which phosphorylates the NF-kappaB inhibitor IkappaB, associates with activated ataxia telangiectasia mutated (ATM) after the induction of D... | NF-kappa-B essential modulator | Medium | convergence | {"qa_id":"medium_convergence_02772","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATM and CASP10 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'We show that [the regulatory subunit of ... | |
medium_convergence_02773 | CHEK1 and BRCA1 both interact with a specific shared protein. Evidence indicates that this protein localizes to the nucleus and associates with Chk1 only following replication stress or other types of DNA damage. Which protein is encoded by the gene corresponding to this shared entity? | Claspin | Medium | convergence | {"qa_id":"medium_convergence_02773","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK1 and BRCA1 both interact with a specific shared protein. Evidence indicates that this protein localizes to the nucleus and associates with Chk1 only fol... | |
medium_convergence_02774 | COPS5 and PLK1 both interact with a shared protein. Evidence indicates that Jun activation domain-binding protein 1 (Jab1) was identified as a binding partner for this shared entity, with this interaction confirmed in mammalian cells. Which protein is encoded by the gene corresponding to this shared entity? | TP53-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02774","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS5 and PLK1 both interact with a shared protein. Evidence indicates that Jun activation domain-binding protein 1 (Jab1) was identified as a binding partne... | |
medium_convergence_02775 | HSPH1 and MYC share multiple interacting partners. One such partner is characterized by evidence stating that it attenuates FBXW7-mediated ubiquitination and degradation of MYC by directly binding to the MYC homology box 1 domain, thereby competing with FBXW7. Which cell type is enriched in this specific interacting pa... | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_02775","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPH1 and MYC share multiple interacting partners. One such partner is characterized by evidence stating that it attenuates FBXW7-mediated ubiquitination and... | |
medium_convergence_02777 | AKAP10 and AKAP1 both interact with a shared protein partner. Evidence regarding this partner states: 'Based on coprecipitation assays, the R binding domain interacts with the N-terminal dimerization domain of RIalpha and RIIalpha.' Which disease is associated with this shared protein partner as a biomarker? | neonatal severe primary hyperparathyroidism | Medium | convergence | {"qa_id":"medium_convergence_02777","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKAP10 and AKAP1 both interact with a shared protein partner. Evidence regarding this partner states: 'Based on coprecipitation assays, the R binding domain ... | |
medium_convergence_02778 | Both Measles morbillivirus and Cardiovirus A are known to upregulate the expression of a specific gene. In a study involving pleural mesothelioma cells (GSE117668), this gene exhibited a log2 fold change of approximately 2.05 and an adjusted p-value of approximately 0.0056. Which cellular component is this gene located... | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_02778","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Cardiovirus A are known to upregulate the expression of a specific gene. In a study involving pleural mesothelioma cells (GSE1... | |
medium_convergence_02779 | Both IRAK2 and S100A8 share binding partners. One such shared partner is implicated in a process where a protein, in complex with its binding partner MRP8 (which corresponds to S100A8), promotes the polymerization of microtubules. Which protein is encoded by this shared binding partner? | Protein S100-A9 | Medium | convergence | {"qa_id":"medium_convergence_02779","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both IRAK2 and S100A8 share binding partners. One such shared partner is implicated in a process where a protein, in complex with its binding partner MRP8 (w... | |
medium_convergence_02780 | PHC1 and H3C1 each interact with more than one shared protein. Evidence concerning one of these shared entities reports that HPH1 and a second homolog coimmunoprecipitate and cofractionate with each other and with BMI1. Which cell type is that shared entity enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_02780","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PHC1 and H3C1 each interact with more than one shared protein. Evidence concerning one of these shared entities reports that HPH1 and a second homolog coimmu... | |
medium_convergence_02781 | TAB1 and IRAK1 both interact with a shared protein partner. Evidence regarding this partner indicates that it forms a complex with TAK1 and TAB1, whereas an alternative complex involves TAK1, TAB1, and TAB3. Which protein is encoded by the gene corresponding to this shared partner? | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 | Medium | convergence | {"qa_id":"medium_convergence_02781","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TAB1 and IRAK1 both interact with a shared protein partner. Evidence regarding this partner indicates that it forms a complex with TAK1 and TAB1, whereas an ... | |
medium_convergence_02782 | PAX6 and WNT9A are both implicated in multiple shared biological processes. One of these shared processes is specifically supported by evidence describing WNT9A's presence in the corneal endothelium from the onset of its differentiation. What is the parent biological process category (via an 'is_a' relationship) for th... | anatomical structure development | Medium | convergence | {"qa_id":"medium_convergence_02782","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PAX6 and WNT9A are both implicated in multiple shared biological processes. One of these shared processes is specifically supported by evidence describing WN... | |
medium_convergence_02783 | Alefacept and Erythromycin both interact with a specific shared drug. Evidence indicates that the combination of this shared drug and Erythromycin (along with sun protection) was found to be efficacious, with the two medications proposed to act synergistically. Which disease is this shared drug indicated for? | autoimmune hepatitis | Medium | convergence | {"qa_id":"medium_convergence_02783","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Alefacept and Erythromycin both interact with a specific shared drug. Evidence indicates that the combination of this shared drug and Erythromycin (along wit... | |
medium_convergence_02784 | DYNLL2 and BECN1 share multiple binding partners. One such shared partner is a protein whose depletion leads to Nedd4-mediated proteasomal degradation of Beclin 1 via Lys11-linked polyubiquitin chains. Which disease is associated with this shared partner as a biomarker? | bipolar disorder | Medium | convergence | {"qa_id":"medium_convergence_02784","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DYNLL2 and BECN1 share multiple binding partners. One such shared partner is a protein whose depletion leads to Nedd4-mediated proteasomal degradation of Bec... | |
medium_convergence_02786 | Calcium ion homeostasis and sodium ion homeostasis are both subtypes of a shared biological process. Evidence for one of these shared processes states: 'Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell.' Which broader biological process is this shared entity... | monoatomic ion homeostasis | Medium | convergence | {"qa_id":"medium_convergence_02786","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Calcium ion homeostasis and sodium ion homeostasis are both subtypes of a shared biological process. Evidence for one of these shared processes states: 'Any ... | |
medium_convergence_02787 | Vaccinia virus and Human mastadenovirus C both upregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that this gene has a log2 fold change of approximately 2.96 and an adjusted p-value of 0.0055. Which disease is causally linked to this gene? | hyperplasia | Medium | convergence | {"qa_id":"medium_convergence_02787","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human mastadenovirus C both upregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indica... | |
medium_convergence_02788 | PRDX4 and AKT1 share multiple interacting partners. One such shared partner is described in a study as an Akt-associated protein that is downregulated upon Akt activation. Which protein is encoded by this specific shared partner? | OTU domain-containing protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02788","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRDX4 and AKT1 share multiple interacting partners. One such shared partner is described in a study as an Akt-associated protein that is downregulated upon A... | |
medium_convergence_02789 | OPTN and MADD both interact with a shared protein. Evidence indicates that Optineurin competitively antagonizes NEMO's binding to polyubiquitinated RIPK1 and that its overexpression inhibits TNFalpha-induced NF-kappaB activation. Which protein corresponds to this shared entity, and what is the name of the protein produ... | Receptor-interacting serine/threonine-protein kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_02789","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"OPTN and MADD both interact with a shared protein. Evidence indicates that Optineurin competitively antagonizes NEMO's binding to polyubiquitinated RIPK1 and... | |
medium_convergence_02790 | NR3C1 and HDAC1 share a common interacting partner. Experimental evidence from GST pull-down assays demonstrates a direct interaction between this shared entity and diverse histone deacetylases (HDACs), as well as a strong interaction between the shared entity and its inhibitory domains. Which protein is encoded by thi... | Nuclear receptor subfamily 0 group B member 2 | Medium | convergence | {"qa_id":"medium_convergence_02790","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NR3C1 and HDAC1 share a common interacting partner. Experimental evidence from GST pull-down assays demonstrates a direct interaction between this shared ent... | |
medium_convergence_02791 | Rhinovirus A and Zika virus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of 1.054 and an adjusted p-value of 0.03849. What is the name of the protein encoded by this gene? | Bromodomain and PHD finger-containing protein 3 | Medium | convergence | {"qa_id":"medium_convergence_02791","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zika virus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2... | |
medium_convergence_02792 | TP53 and UBE2E1 share multiple interacting partners. One such partner is described as a p53-interacting protein called Hades, an E3 ligase that interacts with p53 in the mitochondria. Which disease is associated with this specific entity? | cervical cancer | Medium | convergence | {"qa_id":"medium_convergence_02792","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TP53 and UBE2E1 share multiple interacting partners. One such partner is described as a p53-interacting protein called Hades, an E3 ligase that interacts wit... | |
medium_convergence_02793 | MYBBP1A and MDM2 share a common interaction partner. Evidence indicates that in various breast cancer cell lines, this shared entity is phosphorylated at Ser(338) by the kinase AKT1, an event that induces its interaction and ubiquitination by MDM2, thereby targeting it for protease-dependent degradation. Which protein ... | NAD-dependent protein deacylase sirtuin-6 | Medium | convergence | {"qa_id":"medium_convergence_02793","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYBBP1A and MDM2 share a common interaction partner. Evidence indicates that in various breast cancer cell lines, this shared entity is phosphorylated at Ser... | |
medium_convergence_02794 | Both ILK and LIMS1 interact with a specific shared protein partner. Evidence regarding this partner states: 'Here, we identified a novel ILK-binding protein, affixin, that consists of two tandem calponin homology domains.' Which protein is encoded by this shared partner? | Beta-parvin | Medium | convergence | {"qa_id":"medium_convergence_02794","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both ILK and LIMS1 interact with a specific shared protein partner. Evidence regarding this partner states: 'Here, we identified a novel ILK-binding protein,... | |
medium_convergence_02795 | DCUN1D1 and CUL1 both interact with multiple shared partners. One such partner is involved in a process where a specific F-box protein forms an SCF complex and directly ubiquitinates p57(KIP2) in a phosphorylation-dependent manner. Which protein is encoded by the gene corresponding to this shared partner? | F-box/LRR-repeat protein 12 | Medium | convergence | {"qa_id":"medium_convergence_02795","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCUN1D1 and CUL1 both interact with multiple shared partners. One such partner is involved in a process where a specific F-box protein forms an SCF complex a... | |
medium_convergence_02796 | DHX15 and MYC both interact with a shared protein. Evidence indicates that this shared protein interacts with human PRP43 in HeLa cells. Which protein is encoded by this shared entity? | PIN2/TERF1-interacting telomerase inhibitor 1 | Medium | convergence | {"qa_id":"medium_convergence_02796","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DHX15 and MYC both interact with a shared protein. Evidence indicates that this shared protein interacts with human PRP43 in HeLa cells. Which protein is enc... | |
medium_convergence_02798 | INO80 and ACTL6A share multiple binding partners. One such shared partner is part of a complex where YY1 is tightly associated with the human ATP-dependent INO80-like chromatin-remodeling complex. Which protein is encoded by this shared partner? | INO80 complex subunit C | Medium | convergence | {"qa_id":"medium_convergence_02798","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"INO80 and ACTL6A share multiple binding partners. One such shared partner is part of a complex where YY1 is tightly associated with the human ATP-dependent I... | |
medium_convergence_02799 | Both Measles morbillivirus and Influenza A virus are known to downregulate a specific shared gene. Experimental data for this gene indicates a log2 fold change of approximately -1.46 and an adjusted p-value of 0.047. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_02799","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Influenza A virus are known to downregulate a specific shared gene. Experimental data for this gene indicates a log2 fold chan... | |
medium_convergence_02800 | Human alphaherpesvirus 1 and Cardiovirus A both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of -1.455 and an adjusted p-value of 0.002513. In which cell type is this gene enriched? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_02800","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Cardiovirus A both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114... | |
medium_convergence_02801 | GRIA1 and SLC17A7 share multiple protein interaction partners. One such shared partner is characterized by evidence stating that subunits GluR1-4 associate with indistinguishable efficiency with each other, whereas kainate receptor subunits GluR6 and 7 show a much lower degree of association with GluR1. Which protein i... | Glutamate receptor 2 | Medium | convergence | {"qa_id":"medium_convergence_02801","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRIA1 and SLC17A7 share multiple protein interaction partners. One such shared partner is characterized by evidence stating that subunits GluR1-4 associate w... | |
medium_convergence_02802 | Both IKBKB and IKBKG interact with a common protein partner. Evidence regarding this interaction states: 'We report here that alphaPKC as well as the atypical PKCs bind to the IKKs in vitro and in vivo.' Which protein is encoded by the gene corresponding to this shared partner? | Protein kinase C alpha type | Medium | convergence | {"qa_id":"medium_convergence_02802","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both IKBKB and IKBKG interact with a common protein partner. Evidence regarding this interaction states: 'We report here that alphaPKC as well as the atypica... | |
medium_convergence_02803 | COMMD1 and CUL3 both interact with a shared protein partner. Evidence regarding this partner states: 'The identified variant altered the localization pattern of the protein and abrogated interaction with cullin-3, a ubiquitin-ligase component and known interactor.' Which biological process is this shared partner involv... | intracellular glutamate homeostasis | Medium | convergence | {"qa_id":"medium_convergence_02803","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COMMD1 and CUL3 both interact with a shared protein partner. Evidence regarding this partner states: 'The identified variant altered the localization pattern... | |
medium_convergence_02804 | ERCC4 and FANCA share a common binding partner. Evidence indicates that SLX4 binds to XPF (which is ERCC4) and another subunit of the XPF-ERCC1 and MUS81-EME1 endonucleases, playing a role in DNA interstrand crosslink repair. Based on this context, which protein is the shared binding partner of ERCC4 and FANCA, and wha... | Structure-specific endonuclease subunit SLX1 | Medium | convergence | {"qa_id":"medium_convergence_02804","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERCC4 and FANCA share a common binding partner. Evidence indicates that SLX4 binds to XPF (which is ERCC4) and another subunit of the XPF-ERCC1 and MUS81-EME... | |
medium_convergence_02805 | Zaire ebolavirus and Zika virus both downregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line (study GSE100839) reports a log2 fold change of -1.002 and an adjusted p-value of 0.00368. Which disease is associated with this gene? | melanoma | Medium | convergence | {"qa_id":"medium_convergence_02805","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Zaire ebolavirus and Zika virus both downregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line (study GSE100839... | |
medium_convergence_02806 | Human alphaherpesvirus 3 and Human immunodeficiency virus 1 both downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately -1.043 and an adjusted p-value of 8.674e-06. Which protein is encoded by this gene? | Coronin-1A | Medium | convergence | {"qa_id":"medium_convergence_02806","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 3 and Human immunodeficiency virus 1 both downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study... | |
medium_convergence_02807 | DLG3 and DLG4 both interact with a specific protein family member. Evidence regarding this shared partner states: 'We have isolated here a novel protein family consisting of at least four members which specifically interact with PSD-95/SAP90 and its related proteins through the guanylate kinase domain, and named these ... | Disks large-associated protein 3 | Medium | convergence | {"qa_id":"medium_convergence_02807","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLG3 and DLG4 both interact with a specific protein family member. Evidence regarding this shared partner states: 'We have isolated here a novel protein fami... | |
medium_convergence_02809 | Both Influenza A virus and Human mastadenovirus C are known to upregulate a specific shared gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line (study GSE147507) reports a log2 fold change of approximately 1.031 and an adjusted p-value of 7.191e-07. Which protein is encoded by this g... | Vasculin | Medium | convergence | {"qa_id":"medium_convergence_02809","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Human mastadenovirus C are known to upregulate a specific shared gene. Experimental data for this gene in a non-small cell lung ad... | |
medium_convergence_02810 | CAND1 and AURKB both interact with a shared protein. Evidence regarding this shared protein states: 'Instead, the protein(Δ403-459) auto-ubiquitylates and loses interaction with two important Cullin regulators: the COP9-signalosome and CAND1.' Which cell type is this shared protein enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_02810","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CAND1 and AURKB both interact with a shared protein. Evidence regarding this shared protein states: 'Instead, the protein(Δ403-459) auto-ubiquitylates and lo... | |
medium_convergence_02811 | RPS27A and CBL both interact with a specific shared protein. Contextual evidence notes that while Sprouty2 tyrosine phosphorylation is required for its binding to the Src homology 2-like domain of c-Cbl following fibroblast growth factor (FGF) stimulation, the shared protein in question interacts with c-Cbl/Cbl-b withi... | Protein sprouty homolog 1 | Medium | convergence | {"qa_id":"medium_convergence_02811","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RPS27A and CBL both interact with a specific shared protein. Contextual evidence notes that while Sprouty2 tyrosine phosphorylation is required for its bindi... | |
medium_convergence_02812 | Hepacivirus C and Dengue virus both downregulate a specific gene. Experimental evidence for this gene shows a log2 fold change of approximately -1.22 and an adjusted p-value of 0.0069. Which protein is encoded by this gene? | Glutaredoxin-1 | Medium | convergence | {"qa_id":"medium_convergence_02812","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Dengue virus both downregulate a specific gene. Experimental evidence for this gene shows a log2 fold change of approximately -1.22 and an ... | |
medium_convergence_02813 | Amniotic ectoderm and trophectoderm share a common anatomical classification. Evidence regarding one of these shared entities describes it as the 'Outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo... | epithelium | Medium | convergence | {"qa_id":"medium_convergence_02813","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Amniotic ectoderm and trophectoderm share a common anatomical classification. Evidence regarding one of these shared entities describes it as the 'Outermost ... | |
medium_convergence_02814 | Human polyomavirus 1 and Enterovirus A both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) reports a log2 fold change of 2.602 and an adjusted p-value of 0.009396. Which cellular component is this gene located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_02814","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Enterovirus A both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) reports a... | |
medium_convergence_02815 | RBCK1 and OTULIN both interact with a specific protein that is a component of the LUBAC complex, which is defined as containing this protein, HOIL-1L, and HOIP. Which protein is encoded by the gene corresponding to this shared interaction partner? | Sharpin | Medium | convergence | {"qa_id":"medium_convergence_02815","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RBCK1 and OTULIN both interact with a specific protein that is a component of the LUBAC complex, which is defined as containing this protein, HOIL-1L, and HO... | |
medium_convergence_02816 | Both Measles morbillivirus and Cardiovirus A are associated with the downregulation of a specific gene. Experimental data for this gene indicates a log2 fold change of -1.277 and an adjusted p-value of 0.0003374. Which protein is encoded by this gene? | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | Medium | convergence | {"qa_id":"medium_convergence_02816","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Cardiovirus A are associated with the downregulation of a specific gene. Experimental data for this gene indicates a log2 fold... | |
medium_convergence_02817 | MICU3 and MAIP1 are both associated with multiple shared biological processes. One of these shared processes is linked to an entity described by the following evidence: 'We show that MICU3 forms a disulfide bond-mediated dimer with MICU1, but not with MICU2, and it acts as enhancer of MCU-dependent mitochondrial Ca2+ u... | mitochondrial calcium ion transmembrane transport | Medium | convergence | {"qa_id":"medium_convergence_02817","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MICU3 and MAIP1 are both associated with multiple shared biological processes. One of these shared processes is linked to an entity described by the followin... | |
medium_convergence_02818 | DNMT3L and HDAC1 both interact with a specific shared protein. Evidence indicates that in the ovary, this shared protein interacts with the NuRD complex proteins CHD4 and HDAC1, as well as the core cohesin complex protein RAD21. What molecular function is enabled by this shared protein? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_02818","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNMT3L and HDAC1 both interact with a specific shared protein. Evidence indicates that in the ovary, this shared protein interacts with the NuRD complex prot... | |
medium_convergence_02819 | NBN and ATM both interact with a shared protein. Evidence regarding this shared protein states: 'This effect is dependent on a direct interaction between MRN and the tandem breast cancer carboxy-terminal (BRCT) repeats in [the shared protein], and is accompanied by hyper-phosphorylation of both Nbs1 and [the shared pro... | glioblastoma | Medium | convergence | {"qa_id":"medium_convergence_02819","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NBN and ATM both interact with a shared protein. Evidence regarding this shared protein states: 'This effect is dependent on a direct interaction between MRN... | |
medium_convergence_02820 | Both Hepacivirus C and Zaire ebolavirus are known to upregulate the expression of a specific host gene. Experimental data for one such shared target indicates a log2 fold change of approximately 1.70 and an adjusted p-value of 2.07e-05. What molecular function is enabled by this specific gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_02820","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Hepacivirus C and Zaire ebolavirus are known to upregulate the expression of a specific host gene. Experimental data for one such shared target indicate... | |
medium_convergence_02821 | EPS15 and CD3G both interact with a shared protein. Evidence indicates that this shared protein is localized to clathrin-coated pits at the plasma membrane and binds to EPS15, which serves as an important adaptor protein in clathrin-mediated endocytosis. Which protein is encoded by the gene corresponding to this shared... | F-BAR domain only protein 2 | Medium | convergence | {"qa_id":"medium_convergence_02821","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EPS15 and CD3G both interact with a shared protein. Evidence indicates that this shared protein is localized to clathrin-coated pits at the plasma membrane a... | |
medium_convergence_02822 | YWHAQ and PRKN share multiple interacting partners. One such shared partner is described in evidence stating that 14-3-3tau binds to p21, MDM2, and the C8 subunit of the 20S proteasome during the G1 phase, thereby facilitating the proteasomal targeting of p21. Which protein is encoded by the gene corresponding to this ... | Proteasome subunit alpha type-3 | Medium | convergence | {"qa_id":"medium_convergence_02822","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAQ and PRKN share multiple interacting partners. One such shared partner is described in evidence stating that 14-3-3tau binds to p21, MDM2, and the C8 su... | |
medium_convergence_02823 | PDCD6IP and CD2AP both interact with a shared protein. Evidence regarding one such shared partner states: 'In vitro confrontation experiments showed that the SH3-N domain of SETA interacted with the proline-rich C terminus of AIP1.' Which disease is associated with this specific shared protein? | immunodeficiency 61 | Medium | convergence | {"qa_id":"medium_convergence_02823","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PDCD6IP and CD2AP both interact with a shared protein. Evidence regarding one such shared partner states: 'In vitro confrontation experiments showed that the... | |
medium_convergence_02824 | Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are known to downregulate a specific host gene. Experimental data from a melanoma cell line study (GSE136586) indicates that this gene exhibits a log2 fold change of approximately -1.753 and an adjusted p-value of 2.981e-06. In whic... | plasma membrane | Medium | convergence | {"qa_id":"medium_convergence_02824","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are known to downregulate a specific host gene. Experimental data fro... | |
medium_convergence_02825 | Both Human immunodeficiency virus 1 and Dengue virus are known to upregulate a specific shared gene. Experimental data for this gene in a study (GSE108897) reports a log2 fold change of approximately 1.136 and an adjusted p-value of 0.0122. Which cell type is this gene enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_02825","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus are known to upregulate a specific shared gene. Experimental data for this gene in a study (GSE108897) r... | |
medium_convergence_02826 | CDK9 and ESR1 share multiple interacting partners. One such partner is supported by evidence stating: 'We show that these two proteins physically interact with each other both in vitro as well as in vivo by GST-pull down and coimmunoprecipitation, respectively.' Which disease is associated with this specific interactin... | amyotrophic lateral sclerosis type 18 | Medium | convergence | {"qa_id":"medium_convergence_02826","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK9 and ESR1 share multiple interacting partners. One such partner is supported by evidence stating: 'We show that these two proteins physically interact wi... | |
medium_convergence_02827 | WNT10B and WNT2B are both involved in a shared biological process. Evidence indicates that a subset of genes, including WNT5B, FZD6, and FZD7, showed altered expression in human dermal fibroblasts (hDFs) exposed to DBP for 3 days. Which biological process, connected to this context via a 'part of' relationship, is the ... | cartilage development | Medium | convergence | {"qa_id":"medium_convergence_02827","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"WNT10B and WNT2B are both involved in a shared biological process. Evidence indicates that a subset of genes, including WNT5B, FZD6, and FZD7, showed altered... | |
medium_convergence_02829 | CLU and PIK3R1 share common interaction partners. One such shared partner is ApoJ. Evidence indicates that ApoJ interacts with both type I (RI) and type II (RII) TGF-beta receptors, but not with the epidermal growth factor (EGF) receptor. Which protein, among the shared interaction partners of CLU and PIK3R1, correspon... | TGF-beta receptor type-2 | Medium | convergence | {"qa_id":"medium_convergence_02829","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CLU and PIK3R1 share common interaction partners. One such shared partner is ApoJ. Evidence indicates that ApoJ interacts with both type I (RI) and type II (... | |
medium_convergence_02830 | KCNE5 and KCNIP1 are both involved in more than one shared biological process. Evidence concerning one of these shared entities states: 'Here we show that KCNE5 induces both a time- and voltage-dependent modulation of the KCNQ1 current.' Which biological process is connected to that entity through the 'regulates' relat... | potassium ion transmembrane transport | Medium | convergence | {"qa_id":"medium_convergence_02830","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KCNE5 and KCNIP1 are both involved in more than one shared biological process. Evidence concerning one of these shared entities states: 'Here we show that KC... | |
medium_convergence_02831 | Both Human immunodeficiency virus 1 and Dengue virus are reported to downregulate a specific gene. Experimental data for this gene in macrophages (from study GSE108897) shows a log2 fold change of approximately -3.15 and an adjusted p-value of approximately 0.00024. Which protein is encoded by this gene? | Annexin A3 | Medium | convergence | {"qa_id":"medium_convergence_02831","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus are reported to downregulate a specific gene. Experimental data for this gene in macrophages (from study... | |
medium_convergence_02832 | Rift Valley fever phlebovirus and Zika virus both upregulate a specific gene. Experimental data for this gene in SAEC cells (study GSE102481) reports a log2 fold change of approximately 3.87 and an adjusted p-value of approximately 0.0019. Which protein is encoded by this gene? | Ubl carboxyl-terminal hydrolase 18 | Medium | convergence | {"qa_id":"medium_convergence_02832","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rift Valley fever phlebovirus and Zika virus both upregulate a specific gene. Experimental data for this gene in SAEC cells (study GSE102481) reports a log2 ... | |
medium_convergence_02833 | Both Human alphaherpesvirus 3 and Zaire ebolavirus are associated with the downregulation of a specific gene. Experimental data from a melanoma cell line (study GSE136586) indicates that this gene exhibits a log2 fold change of approximately -1.31 and an adjusted p-value of approximately 8.58e-05. Which protein is enco... | Protein cornichon homolog 3 | Medium | convergence | {"qa_id":"medium_convergence_02833","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Zaire ebolavirus are associated with the downregulation of a specific gene. Experimental data from a melanoma cell line (st... | |
medium_convergence_02834 | HNRNPA1 and PRKN share a common interacting partner. Evidence indicates that this shared partner mediates IκBα degradation via a specific interaction between its PDZ domain and a short linear sequence motif located in the C-terminus of HNRNPA1. Which protein is encoded by this shared interacting partner? | 26S proteasome non-ATPase regulatory subunit 9 | Medium | convergence | {"qa_id":"medium_convergence_02834","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HNRNPA1 and PRKN share a common interacting partner. Evidence indicates that this shared partner mediates IκBα degradation via a specific interaction between... | |
medium_convergence_02835 | AKT1 and KRAS share multiple interacting partners. One such shared partner was identified as a novel protein binding to PKB via a yeast two-hybrid screening system. Which disease is associated with this specific shared partner as a biomarker? | adenoviridae infectious disease | Medium | convergence | {"qa_id":"medium_convergence_02835","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKT1 and KRAS share multiple interacting partners. One such shared partner was identified as a novel protein binding to PKB via a yeast two-hybrid screening ... | |
medium_convergence_02838 | Primary ovarian follicle growth and preantral ovarian follicle growth are both subtypes of a specific biological process. Evidence regarding the transition from primary to preantral stages describes an increase in follicle size, including oocyte growth and granulosa/theca cell proliferation, until multiple layers of gr... | ovulation cycle | Medium | convergence | {"qa_id":"medium_convergence_02838","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Primary ovarian follicle growth and preantral ovarian follicle growth are both subtypes of a specific biological process. Evidence regarding the transition f... | |
medium_convergence_02840 | ERCC6 and POLR1E both interact with a shared protein partner. Evidence indicates that a protein encoded by the gene corresponding to this shared partner interacts with PAF53 through its N-terminal segment. Which protein, encoded by the gene corresponding to this shared partner, is the target of the 'encodes' relationsh... | DNA-directed RNA polymerase I subunit RPA34 | Medium | convergence | {"qa_id":"medium_convergence_02840","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERCC6 and POLR1E both interact with a shared protein partner. Evidence indicates that a protein encoded by the gene corresponding to this shared partner inte... | |
medium_convergence_02841 | GINS2 and CLSPN both interact with a common protein partner. Evidence indicates that the interaction between Claspin and this specific DNA helicase subunit is abolished upon Cdc7 inhibition. Which disease is associated with this protein partner? | autosomal dominant nonsyndromic hearing loss 70 | Medium | convergence | {"qa_id":"medium_convergence_02841","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GINS2 and CLSPN both interact with a common protein partner. Evidence indicates that the interaction between Claspin and this specific DNA helicase subunit i... | |
medium_convergence_02842 | CDK12 and CCNH both interact with a shared protein partner. Evidence regarding this partner states: 'Here we use a yeast two-hybrid screen to show that a new human cyclin (cyclin H) is a [shared protein partner]-associated protein.' Which disease is associated with this shared protein partner through genomic alteration... | small cell lung carcinoma | Medium | convergence | {"qa_id":"medium_convergence_02842","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK12 and CCNH both interact with a shared protein partner. Evidence regarding this partner states: 'Here we use a yeast two-hybrid screen to show that a new... | |
medium_convergence_02843 | Both Vaccinia virus and Human respirovirus 3 are known to upregulate a specific gene. Experimental data from a study on cervical adenocarcinoma cell lines (GSE11238) indicates that for one such shared target, the log2 fold change is 1.953 and the adjusted p-value is 1.358e-12. Which disease is associated with this spec... | developmental and epileptic encephalopathy, 39 | Medium | convergence | {"qa_id":"medium_convergence_02843","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Vaccinia virus and Human respirovirus 3 are known to upregulate a specific gene. Experimental data from a study on cervical adenocarcinoma cell lines (G... | |
medium_convergence_02844 | ERCC1 and FANCA both interact with a common protein. Evidence regarding this shared partner indicates that its N terminus stabilizes the interaction with FANCA and FANCG and is essential for the binding of the FANCC/FANCE subcomplex. Which gene does this shared partner interact with? | GINS2 | Medium | convergence | {"qa_id":"medium_convergence_02844","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERCC1 and FANCA both interact with a common protein. Evidence regarding this shared partner indicates that its N terminus stabilizes the interaction with FAN... | |
medium_convergence_02845 | MTOR and ATP6V0B share a common binding partner. Evidence indicates that this shared partner binds to the TOR complex specifically, independently of its ability to bind TSC2, through separate interactions with the mTOR catalytic domain and with LST8. Which protein is encoded by the gene corresponding to this shared par... | GTP-binding protein Rheb | Medium | convergence | {"qa_id":"medium_convergence_02845","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MTOR and ATP6V0B share a common binding partner. Evidence indicates that this shared partner binds to the TOR complex specifically, independently of its abil... | |
medium_convergence_02846 | JAZF1 and MYCN share multiple interacting partners. One such shared partner is supported by evidence stating: 'The interaction between a specific protein and n-Myc was validated by pull-down experiments.' Which protein is encoded by this specific shared partner? | YEATS domain-containing protein 4 | Medium | convergence | {"qa_id":"medium_convergence_02846","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"JAZF1 and MYCN share multiple interacting partners. One such shared partner is supported by evidence stating: 'The interaction between a specific protein and... | |
medium_convergence_02847 | HIST2H3A and H3C1 each share a binding partner with another gene. Evidence concerning one of these shared partners states: 'Notably, acetylated this protein binds to histone H3 phosphorylation at threonine 11 (H3T11P) and is essential for DNA damage-induced reduction of H3T11P and transcriptional repression of its down... | regulatory T cell | Medium | convergence | {"qa_id":"medium_convergence_02847","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HIST2H3A and H3C1 each share a binding partner with another gene. Evidence concerning one of these shared partners states: 'Notably, acetylated this protein ... | |
medium_convergence_02848 | AKAP8 and IGF2BP3 both interact with a shared protein. Evidence regarding this shared protein indicates that Yeast two-hybrid cloning identified one of its binding partners as an RNA helicase. Which protein is encoded by this shared gene? | Probable ATP-dependent RNA helicase DDX5 | Medium | convergence | {"qa_id":"medium_convergence_02848","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKAP8 and IGF2BP3 both interact with a shared protein. Evidence regarding this shared protein indicates that Yeast two-hybrid cloning identified one of its b... | |
medium_convergence_02849 | PRMT5 and INTS1 share a common interacting partner. Evidence regarding this partner states: 'In this study, we utilized a biochemical approach to demonstrate that the shared partner was specifically associated with the protein arginine methyltransferases PRMT1 and PRMT5 and that its methylation regulated its interactio... | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_02849","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRMT5 and INTS1 share a common interacting partner. Evidence regarding this partner states: 'In this study, we utilized a biochemical approach to demonstrate... | |
medium_convergence_02850 | BRD8 and MEAF6 share multiple protein interaction partners. One such shared partner is part of a newly identified abundant native complex described as 'X-MRGBP-BRD8-EP400NL', which is functionally similar to the yeast TINTIN complex. Which protein is encoded by this shared partner? | Mortality factor 4-like protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02850","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD8 and MEAF6 share multiple protein interaction partners. One such shared partner is part of a newly identified abundant native complex described as 'X-MRG... | |
medium_convergence_02851 | KCNQ1 and KCNE2 are both involved in more than one shared biological process. One of these shared processes is linked to evidence stating: 'These data define KVLQT1 as a novel cardiac potassium channel gene and show that mutations in this gene cause susceptibility to ventricular tachyarrhythmias and sudden death.' Whic... | ventricular cardiac muscle cell membrane repolarization | Medium | convergence | {"qa_id":"medium_convergence_02851","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KCNQ1 and KCNE2 are both involved in more than one shared biological process. One of these shared processes is linked to evidence stating: 'These data define... | |
medium_convergence_02852 | RAD9A and ATRIP both interact with a common protein partner. Experimental evidence indicates that this shared partner interacts with the checkpoint protein hRad9. Which protein is encoded by the gene corresponding to this shared partner? | DNA topoisomerase 2-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02852","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAD9A and ATRIP both interact with a common protein partner. Experimental evidence indicates that this shared partner interacts with the checkpoint protein h... | |
medium_convergence_02853 | Dengue virus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) shows a log2 fold change of approximately -1.27 and an adjusted p-value of approximately 0.037. In which cellular component is the protein product of this gene located? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_02853","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) shows a log2 fold ... | |
medium_convergence_02854 | MLH1 and MSH2 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Previous biochemical and physical studies have shown that hMSH2 forms specific mispair binding complexes with hMSH3 and hMSH6.' Which protein is encoded by that shared partner? | DNA mismatch repair protein Msh3 | Medium | convergence | {"qa_id":"medium_convergence_02854","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MLH1 and MSH2 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Previous biochemical and physical... | |
medium_convergence_02855 | COPS5 and AKT1 share multiple interacting partners. One such shared partner is described in evidence stating: 'We show that a specific protein interacts with at least three proteins, one of which is JAB1, a Jun activation domain binding protein that can bind to p27(Kip1) and is involved in the cytoplasmic transportatio... | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | Medium | convergence | {"qa_id":"medium_convergence_02855","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS5 and AKT1 share multiple interacting partners. One such shared partner is described in evidence stating: 'We show that a specific protein interacts with... | |
medium_convergence_02856 | Amikacin and Kanamycin both interact with a specific drug. Evidence indicates that this drug enhances the bacteriostatic and bactericidal activity of these two aminoglycosides against most gram-negative bacilli, although bactericidal activity was significantly diminished in 4 of 65 strains. Which drug interacts with th... | Picosulfuric acid | Medium | convergence | {"qa_id":"medium_convergence_02856","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Amikacin and Kanamycin both interact with a specific drug. Evidence indicates that this drug enhances the bacteriostatic and bactericidal activity of these t... | |
medium_convergence_02857 | Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are known to downregulate a specific shared host gene. Experimental data from a melanoma cell line study (GSE136586) indicates that this shared target exhibits a log2 fold change of approximately -1.39 and an adjusted p-value of 2.7... | CDK5RAP3 | Medium | convergence | {"qa_id":"medium_convergence_02857","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are known to downregulate a specific shared host gene. Experimental d... | |
medium_convergence_02858 | Both Measles morbillivirus and Dengue virus are reported to upregulate a specific gene. Experimental data for this gene shows a log2 fold change of approximately 2.44 and an adjusted p-value of 0.01034. Which protein is encoded by this gene? | Peregrin | Medium | convergence | {"qa_id":"medium_convergence_02858","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Dengue virus are reported to upregulate a specific gene. Experimental data for this gene shows a log2 fold change of approxima... |
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