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medium_convergence_02859 | The posterior nuclear complex of the thalamus and the thalamic complex share a common anatomical classification. Evidence regarding one of these shared classifications describes a part of the thalamus comprising ill-defined cellular groups in the caudal thalamus at the meso-diencephalic junction. This structure is not ... | gray matter | Medium | convergence | {"qa_id":"medium_convergence_02859","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The posterior nuclear complex of the thalamus and the thalamic complex share a common anatomical classification. Evidence regarding one of these shared class... | |
medium_convergence_02860 | CEP131 and CC2D2A both interact with a shared protein partner. For one of these partners, experimental evidence indicates that the proteins can physically interact in vitro, as demonstrated by yeast two-hybrid and GST pull-down assays. Which disease is associated with this specific protein partner via a biomarker relat... | retinal degeneration | Medium | convergence | {"qa_id":"medium_convergence_02860","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CEP131 and CC2D2A both interact with a shared protein partner. For one of these partners, experimental evidence indicates that the proteins can physically in... | |
medium_convergence_02861 | EGFR and ERBB3 both interact with a specific protein. Evidence indicates that this protein coprecipitates with activated epidermal growth factor and platelet-derived growth factor (PDGF) receptors, and that phosphorylated tyrosine residues on the PDGF receptor mediate its tyrosine phosphorylation. In which cell type is... | memory B cell | Medium | convergence | {"qa_id":"medium_convergence_02861","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and ERBB3 both interact with a specific protein. Evidence indicates that this protein coprecipitates with activated epidermal growth factor and platelet... | |
medium_convergence_02862 | DUSP1 and EGFR share common interacting partners. One such shared partner has been shown to interact with the phosphatase DUSP1 to negatively regulate JNK activation, and its knockdown promotes the proteasomal degradation of DUSP1. Which protein is encoded by the gene corresponding to this shared partner? | Ubiquitin carboxyl-terminal hydrolase 33 | Medium | convergence | {"qa_id":"medium_convergence_02862","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DUSP1 and EGFR share common interacting partners. One such shared partner has been shown to interact with the phosphatase DUSP1 to negatively regulate JNK ac... | |
medium_convergence_02863 | BMI1 and L3MBTL2 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'The RING domains of both proteins mediate their association and subsequent stabilization.' Which protein is connected to that shared partner through the 'encodes' relationship? | E3 ubiquitin-protein ligase RING2 | Medium | convergence | {"qa_id":"medium_convergence_02863","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMI1 and L3MBTL2 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'The RING domains of both ... | |
medium_convergence_02864 | BMP8A and BMPR1B both interact with a shared receptor. Evidence indicates this receptor is a transmembrane serine/threonine kinase that binds BMP-2 and BMP-7 in association with multiple type I receptors, including BMPR-IA/Brk1, BMPR-IB, and ActR-I. Which disease is causally linked to this specific receptor? | portal hypertension | Medium | convergence | {"qa_id":"medium_convergence_02864","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMP8A and BMPR1B both interact with a shared receptor. Evidence indicates this receptor is a transmembrane serine/threonine kinase that binds BMP-2 and BMP-7... | |
medium_convergence_02865 | EP300 and SKP2 both interact with a shared protein. Evidence concerning this shared entity states: 'Furthermore, we provide evidence supporting the formation of a complex between both factors in vivo and in vitro.' Which protein is encoded by this shared entity? | Paired box protein Pax-8 | Medium | convergence | {"qa_id":"medium_convergence_02865","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and SKP2 both interact with a shared protein. Evidence concerning this shared entity states: 'Furthermore, we provide evidence supporting the formation... | |
medium_convergence_02866 | KPNB1 and NUP107 both interact with a specific nucleoporin. Evidence regarding this shared interaction partner states: 'We employed a phage display system to search for proteins that interact with transportin 1 (TRN1), the import receptor for shuttling hnRNP proteins with an M9 nuclear localization sequence (NLS), and ... | Nuclear pore complex protein Nup153 | Medium | convergence | {"qa_id":"medium_convergence_02866","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KPNB1 and NUP107 both interact with a specific nucleoporin. Evidence regarding this shared interaction partner states: 'We employed a phage display system to... | |
medium_convergence_02867 | RRAS2 and HRAS share a common interacting partner. Evidence indicates that this partner specifically interacts with both dominant negative and nucleotide-free forms of H-Ras and N-Ras, but not with their corresponding oncogenic forms. Which protein is encoded by the gene corresponding to this shared interacting partner... | Rap1 GTPase-GDP dissociation stimulator 1 | Medium | convergence | {"qa_id":"medium_convergence_02867","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RRAS2 and HRAS share a common interacting partner. Evidence indicates that this partner specifically interacts with both dominant negative and nucleotide-fre... | |
medium_convergence_02868 | FYN and IQGAP1 both interact with a specific gene product. Evidence regarding this shared partner indicates that a pulldown assay using purified proteins demonstrates that the partner directly interacts with the protein encoded by KDR. Which protein is encoded by this shared gene product? | Vascular endothelial growth factor receptor 2 | Medium | convergence | {"qa_id":"medium_convergence_02868","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FYN and IQGAP1 both interact with a specific gene product. Evidence regarding this shared partner indicates that a pulldown assay using purified proteins dem... | |
medium_convergence_02869 | ERCC1 and ERCC4 both interact with a shared protein partner. Evidence indicates that SLX4 binds to XPF (which is ERCC4) and another subunit within the XPF-ERCC1 endonuclease complex, playing a role in DNA interstrand crosslink repair. Based on this context, which protein is the shared partner connected to ERCC1 and ERC... | Structure-specific endonuclease subunit SLX1 | Medium | convergence | {"qa_id":"medium_convergence_02869","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERCC1 and ERCC4 both interact with a shared protein partner. Evidence indicates that SLX4 binds to XPF (which is ERCC4) and another subunit within the XPF-ER... | |
medium_convergence_02870 | GNA15 and GNAI3 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'In vitro binding assays reveal that RGS5 and this shared partner bind to Galphai and Galphao subunits of heterotrimeric G-proteins, but not to Galphas.' Which cellular component is this spe... | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_02870","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNA15 and GNAI3 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'In vitro binding assays re... | |
medium_convergence_02871 | Urokinase and Tenecteplase both interact with a specific shared entity. Clinical evidence regarding this entity describes its safety and efficacy when used in conjunction with intracoronary urokinase in patients requiring angioplasty. Which disease is this entity indicated for? | intermediate coronary syndrome | Medium | convergence | {"qa_id":"medium_convergence_02871","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Urokinase and Tenecteplase both interact with a specific shared entity. Clinical evidence regarding this entity describes its safety and efficacy when used i... | |
medium_convergence_02872 | DAXX and GAPDH both interact with a shared protein entity. Evidence indicates that this shared entity is a modulator of apoptosis and a repressor of basal transcription, and it was identified in a two-hybrid screen as a protein capable of interacting with a trimeric form of human heat shock factor 1. Which protein is e... | Heat shock factor protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02872","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAXX and GAPDH both interact with a shared protein entity. Evidence indicates that this shared entity is a modulator of apoptosis and a repressor of basal tr... | |
medium_convergence_02873 | MTREX and NCBP1 share multiple binding partners. One of these shared partners is a protein that binds the cap-binding complex (CBC), which is universally present on capped RNAs, and also associates with the nuclear exosome targeting (NEXT) complex, thereby linking to RNA decay. Which biological process is this specific... | RNA destabilization | Medium | convergence | {"qa_id":"medium_convergence_02873","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MTREX and NCBP1 share multiple binding partners. One of these shared partners is a protein that binds the cap-binding complex (CBC), which is universally pre... | |
medium_convergence_02874 | Human alphaherpesvirus 1 and Human alphaherpesvirus 3 both upregulate a specific gene. Evidence for this gene in foreskin fibroblast cell lines (study GSE100576) reports a log2 fold change of approximately 1.709 and an adjusted p-value of 0.008871. Which cellular component is this gene located in? | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_02874","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human alphaherpesvirus 3 both upregulate a specific gene. Evidence for this gene in foreskin fibroblast cell lines (study GSE100... | |
medium_convergence_02875 | Both Measles morbillivirus and Cardiovirus A are associated with the upregulation of a specific gene. Experimental data for this gene reports a log2 fold change of approximately 1.086 and an adjusted p-value of 0.02894. Which protein is encoded by this gene? | WAP four-disulfide core domain protein 2 | Medium | convergence | {"qa_id":"medium_convergence_02875","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Cardiovirus A are associated with the upregulation of a specific gene. Experimental data for this gene reports a log2 fold cha... | |
medium_convergence_02876 | KRAS and MAPK3 share multiple binding partners. One such partner is implicated in a mechanism where Sur-8 interacts with Ras and Raf to form a ternary complex. Which cell type is enriched for this specific shared partner? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_02876","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KRAS and MAPK3 share multiple binding partners. One such partner is implicated in a mechanism where Sur-8 interacts with Ras and Raf to form a ternary comple... | |
medium_convergence_02877 | MECP2 and PPARA each interact with more than one shared protein partner. Evidence concerning one shared entity reports that methylated DNA assembled into chromatin binds the transcriptional repressor MeCP2, which cofractionates with Sin3 and histone deacetylase. Which protein is connected to that entity through the 'en... | Paired amphipathic helix protein Sin3a | Medium | convergence | {"qa_id":"medium_convergence_02877","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MECP2 and PPARA each interact with more than one shared protein partner. Evidence concerning one shared entity reports that methylated DNA assembled into chr... | |
medium_convergence_02878 | CDK3 and CDK5 both interact with a specific shared protein. Evidence regarding this shared entity states: 'Our results show that p27 binds to Cdk5 and Cdk2 with similar, slow kinetics.' Which protein is encoded by the gene corresponding to this shared entity? | Cyclin-dependent kinase inhibitor 1B | Medium | convergence | {"qa_id":"medium_convergence_02878","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK3 and CDK5 both interact with a specific shared protein. Evidence regarding this shared entity states: 'Our results show that p27 binds to Cdk5 and Cdk2 w... | |
medium_convergence_02880 | Enterovirus A and Cardiovirus A both upregulate a specific gene. Evidence for this gene in rhabdomyosarcoma cells (study GSE103308) reports a log2 fold change of approximately 3.45 and an adjusted p-value of 0.000571. Which protein is encoded by this gene? | Toll-like receptor 2 | Medium | convergence | {"qa_id":"medium_convergence_02880","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Enterovirus A and Cardiovirus A both upregulate a specific gene. Evidence for this gene in rhabdomyosarcoma cells (study GSE103308) reports a log2 fold chang... | |
medium_convergence_02881 | CD80 and CD86 both interact with a specific shared protein partner. Experimental evidence regarding this partner states: 'We have identified, by site-directed mutagenesis of soluble forms of CD80 and CD86, residues in both the IgV and IgC domains that are important for CTLA4Ig and CD28Ig binding.' Which gene product in... | PPP2R5A | Medium | convergence | {"qa_id":"medium_convergence_02881","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CD80 and CD86 both interact with a specific shared protein partner. Experimental evidence regarding this partner states: 'We have identified, by site-directe... | |
medium_convergence_02883 | Fluorouracil and Methotrexate both interact with a specific shared drug entity. Clinical evidence indicates that this shared entity can be used safely in combination with Fluorouracil and other antitumor agents. Which disease is this shared entity indicated for? | osteosarcoma | Medium | convergence | {"qa_id":"medium_convergence_02883","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Fluorouracil and Methotrexate both interact with a specific shared drug entity. Clinical evidence indicates that this shared entity can be used safely in com... | |
medium_convergence_02884 | AKT1 and UBE2D3 share multiple interacting partners. One such partner is described in evidence stating that Akt was found to directly interact with a specific protein and to be ubiquitinated by this protein in vitro and in vivo. Which protein is connected to this specific interacting partner through the 'encodes' relat... | Mitochondrial ubiquitin ligase activator of NFKB 1 | Medium | convergence | {"qa_id":"medium_convergence_02884","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKT1 and UBE2D3 share multiple interacting partners. One such partner is described in evidence stating that Akt was found to directly interact with a specifi... | |
medium_convergence_02885 | IRAK1 and IRAK4 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Here we show that, before IL-1beta treatment, this protein is present in a complex with IRAK, and that recruitment of this protein-IRAK complexes to the activated receptor complex occurs through... | asthma | Medium | convergence | {"qa_id":"medium_convergence_02885","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IRAK1 and IRAK4 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Here we show that, before IL-1b... | |
medium_convergence_02886 | CLEC16A and PRKN (Parkin) both interact with a specific shared protein. Evidence regarding one of these shared partners states: 'We demonstrate that parkin interacts with and robustly ubiquitinates this protein in human neural cells.' Which protein is encoded by the gene corresponding to this interaction partner? | Vacuolar protein sorting-associated protein 35 | Medium | convergence | {"qa_id":"medium_convergence_02886","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CLEC16A and PRKN (Parkin) both interact with a specific shared protein. Evidence regarding one of these shared partners states: 'We demonstrate that parkin i... | |
medium_convergence_02887 | EGFR and GSK3B share a common interaction partner. Experimental evidence indicates that this shared partner forms a physical complex with EGFRvIII. Which protein is encoded by this shared interaction partner? | Hepatocyte growth factor receptor | Medium | convergence | {"qa_id":"medium_convergence_02887","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and GSK3B share a common interaction partner. Experimental evidence indicates that this shared partner forms a physical complex with EGFRvIII. Which pro... | |
medium_convergence_02888 | EMD and LMNB1 share multiple interacting partners. One such shared partner is identified in a study using a mass spectrometry-based approach, which reports that lamins, lamin-binding proteins, retinoblastoma protein (pRb), lamina-associated polypeptide 2α (LAP2α), and emerin interact with this specific entity. Which pr... | E3 ubiquitin-protein ligase RNF123 | Medium | convergence | {"qa_id":"medium_convergence_02888","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EMD and LMNB1 share multiple interacting partners. One such shared partner is identified in a study using a mass spectrometry-based approach, which reports t... | |
medium_convergence_02889 | Both Vaccinia virus and Enterovirus A are known to downregulate the expression of a specific host gene. In a study using a cervical adenocarcinoma cell line (GSE11238), the downregulation of this gene was associated with a log2 fold change of -3.396 and an adjusted p-value of 0.006248. What molecular function is enable... | DNA-binding transcription factor activity | Medium | convergence | {"qa_id":"medium_convergence_02889","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Vaccinia virus and Enterovirus A are known to downregulate the expression of a specific host gene. In a study using a cervical adenocarcinoma cell line ... | |
medium_convergence_02890 | MECOM and CHD5 both interact with a shared protein entity. Experimental evidence indicates that Evi1 (the protein product of MECOM) interacts with this specific entity, but does not interact with other MBD family members such as Mbd1, Mbd2, Mbd4, or MeCP2. Which disease is associated with this shared entity via a bioma... | autism spectrum disorder | Medium | convergence | {"qa_id":"medium_convergence_02890","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MECOM and CHD5 both interact with a shared protein entity. Experimental evidence indicates that Evi1 (the protein product of MECOM) interacts with this speci... | |
medium_convergence_02891 | GATA3 and IL17RB are both involved in more than one shared biological process. Evidence concerning one of these shared processes indicates that siRNA targeting GATA3 inhibited the binding of NFAT1 to the IL-13 promoter in activated T cells, leading to a reduction in IL-13 transcription. Which biological process is conn... | interleukin-13 production | Medium | convergence | {"qa_id":"medium_convergence_02891","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GATA3 and IL17RB are both involved in more than one shared biological process. Evidence concerning one of these shared processes indicates that siRNA targeti... | |
medium_convergence_02892 | PML and RARA both interact with a shared protein. Evidence regarding one such shared partner states: 'We mapped the region in the shared protein that interacts with PML to the C-terminal transactivation domain.' Which protein is encoded by this shared partner? | Serum response factor | Medium | convergence | {"qa_id":"medium_convergence_02892","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PML and RARA both interact with a shared protein. Evidence regarding one such shared partner states: 'We mapped the region in the shared protein that interac... | |
medium_convergence_02893 | ANAPC11 and CDC16 share common binding partners. One such shared partner is reported to coimmunoprecipitate with p55CDC and Mad2 in extracts prepared from M phase, but not from interphase HeLa cells. Which gene interacts with this shared partner? | CDH1 | Medium | convergence | {"qa_id":"medium_convergence_02893","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC11 and CDC16 share common binding partners. One such shared partner is reported to coimmunoprecipitate with p55CDC and Mad2 in extracts prepared from M ... | |
medium_convergence_02894 | BUB3 and CDC20 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In extracts prepared from M phase, but not from interphase HeLa cells, p55CDC coimmunoprecipitates with three important elements of the M phase checkpoint machinery: this shared protein, Cdc16, and Mad2.' Whi... | Cell division cycle protein 27 homolog | Medium | convergence | {"qa_id":"medium_convergence_02894","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BUB3 and CDC20 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In extracts prepared from M phase, but not fr... | |
medium_convergence_02895 | DLG4 and YWHAG share common interaction partners. One such partner is described in evidence stating: 'We previously reported that NBCn1 interacts with the postsynaptic density protein PSD-95 in the brain.' Which protein is encoded by this shared interaction partner? | Sodium bicarbonate cotransporter 3 | Medium | convergence | {"qa_id":"medium_convergence_02895","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLG4 and YWHAG share common interaction partners. One such partner is described in evidence stating: 'We previously reported that NBCn1 interacts with the po... | |
medium_convergence_02896 | Codeine and Thiethylperazine both interact with a specific drug. Evidence regarding this shared drug indicates that, when used in a dose that did not affect the locomotor activity of mice, it completely blocked or even reversed the stimulatory action of morphine and fentanyl, and potentiated the depression of locomotor... | schizophrenia | Medium | convergence | {"qa_id":"medium_convergence_02896","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Codeine and Thiethylperazine both interact with a specific drug. Evidence regarding this shared drug indicates that, when used in a dose that did not affect ... | |
medium_convergence_02897 | DIS3 and EXOSC7 both interact with a shared protein. Evidence regarding this shared entity states: 'Here, we demonstrate the association of two different Dis3p homologs--hDIS3 and hDIS3L--with the human exosome core.' Which disease is associated with this shared entity? | pontocerebellar hypoplasia, type 1D | Medium | convergence | {"qa_id":"medium_convergence_02897","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DIS3 and EXOSC7 both interact with a shared protein. Evidence regarding this shared entity states: 'Here, we demonstrate the association of two different Dis... | |
medium_convergence_02898 | Enterovirus A and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in rhabdomyosarcoma cells reports a log2 fold change of -2.163 and an adjusted p-value of 0.03916. Which disease is associated with this gene through genomic alterations? | ghosal hematodiaphyseal dysplasia | Medium | convergence | {"qa_id":"medium_convergence_02898","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Enterovirus A and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in rhabdomyosarcoma cells reports a log2 fold change of... | |
medium_convergence_02899 | ADAM10 and EFNA5 both interact with a specific receptor tyrosine kinase. Evidence indicates that ephrin-A2, ephrin-A3, and ephrin-A5 bind to this receptor, but they do not bind to EphA4. Which disease is associated with this receptor? | dental caries | Medium | convergence | {"qa_id":"medium_convergence_02899","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ADAM10 and EFNA5 both interact with a specific receptor tyrosine kinase. Evidence indicates that ephrin-A2, ephrin-A3, and ephrin-A5 bind to this receptor, b... | |
medium_convergence_02900 | WWP1 and ESR1 both interact with a shared protein entity. Evidence regarding this entity states: 'Our analysis revealed that ERalpha formed a protein complex with Smad and the ubiquitin ligase Smurf, and enhanced Smad ubiquitination and subsequent degradation in an estrogen-dependent manner.' Which protein is connected... | SMAD family member 2 | Medium | convergence | {"qa_id":"medium_convergence_02900","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"WWP1 and ESR1 both interact with a shared protein entity. Evidence regarding this entity states: 'Our analysis revealed that ERalpha formed a protein complex... | |
medium_convergence_02901 | Human betaherpesvirus 5 and Human polyomavirus 1 both upregulate a specific gene. Experimental data for this gene in a foreskin fibroblast cell line (study GSE132081) reports a log2 fold change of approximately 2.12 and an adjusted p-value of approximately 0.0015. Which cell type is this gene enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_02901","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Human polyomavirus 1 both upregulate a specific gene. Experimental data for this gene in a foreskin fibroblast cell line (study G... | |
medium_convergence_02902 | EIF1AX and EIF2S1 both interact with a shared protein partner. Evidence regarding this partner states: 'These findings support the idea that phosphorylation of the serine 51 residue in eIF2alpha promotes complex formation between eIF2alpha(P) and eIF2B and thereby inhibits the GNE activity of eIF2B.' Which protein is e... | Eukaryotic translation initiation factor 2 subunit 2 | Medium | convergence | {"qa_id":"medium_convergence_02902","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF1AX and EIF2S1 both interact with a shared protein partner. Evidence regarding this partner states: 'These findings support the idea that phosphorylation ... | |
medium_convergence_02903 | Both Human alphaherpesvirus 3 and Human immunodeficiency virus 1 are reported to downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) shows a log2 fold change of -1.276 and an adjusted p-value of 1.047e-05. Which protein is encoded by this gene? | BTB/POZ domain-containing protein KCTD12 | Medium | convergence | {"qa_id":"medium_convergence_02903","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Human immunodeficiency virus 1 are reported to downregulate a specific gene. Experimental data for this gene in a melanoma ... | |
medium_convergence_02904 | Enterovirus A and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) shows a log2 fold change of approximately 5.476 and an adjusted p-value of 0.01154. Which protein does this gene product interact with? | RHOB | Medium | convergence | {"qa_id":"medium_convergence_02904","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Enterovirus A and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) shows a log2 fol... | |
medium_convergence_02905 | CDK2 and CSNK2A1 share multiple interaction partners. One such shared partner is implicated in evidence stating that 'Cyclin A-cdk2 appears to associate with NF-Y both in vitro and in vivo.' Which protein product is encoded by this specific shared partner? | Nuclear transcription factor Y subunit alpha | Medium | convergence | {"qa_id":"medium_convergence_02905","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and CSNK2A1 share multiple interaction partners. One such shared partner is implicated in evidence stating that 'Cyclin A-cdk2 appears to associate with... | |
medium_convergence_02906 | EP300 and MYC share multiple interaction partners. One such partner is implicated in a targeted recruitment mechanism, supported by evidence of direct interactions between SET1C and p53, as well as SET1C and p300. Which gene does this specific shared partner bind to? | ZC3H4 | Medium | convergence | {"qa_id":"medium_convergence_02906","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and MYC share multiple interaction partners. One such partner is implicated in a targeted recruitment mechanism, supported by evidence of direct intera... | |
medium_convergence_02907 | Both IKBKG and BCL10 physically interact with a common protein. Evidence regarding this shared partner states: 'In addition, Tax physically interacts with a MAP3K family kinase and mediates the recruitment of IKK to this kinase.' Which disease is associated with this shared protein through genomic alterations? | cardiospondylocarpofacial syndrome | Medium | convergence | {"qa_id":"medium_convergence_02907","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both IKBKG and BCL10 physically interact with a common protein. Evidence regarding this shared partner states: 'In addition, Tax physically interacts with a ... | |
medium_convergence_02909 | Both CDC42 and CDH1 interact with a specific protein. Experimental evidence indicates that a recombinant form of this protein specifically interacts with GTPgammaS-Cdc42 and GTPgammaS-Rac1. Which protein is encoded by the gene corresponding to this interacting entity? | Ras GTPase-activating-like protein IQGAP1 | Medium | convergence | {"qa_id":"medium_convergence_02909","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both CDC42 and CDH1 interact with a specific protein. Experimental evidence indicates that a recombinant form of this protein specifically interacts with GTP... | |
medium_convergence_02910 | PAXIP1 and NBN both interact with a common protein partner. Evidence indicates that this partner, identified as hPTIP, exhibits increased association with a DNA damage response protein specifically in response to ionizing radiation, but not to other DNA-damaging agents. Which disease is linked to this entity via a biom... | glioblastoma | Medium | convergence | {"qa_id":"medium_convergence_02910","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PAXIP1 and NBN both interact with a common protein partner. Evidence indicates that this partner, identified as hPTIP, exhibits increased association with a ... | |
medium_convergence_02911 | CSNK2A1 and MSH6 share multiple interacting partners. One such shared partner is described in a study stating: 'In this study, we show that each subunit of the human 9-1-1 complex physically interacts with hMSH2, hMSH3, and hMSH6.' Which disease is associated with this specific shared partner via genomic alterations? | thyroid gland papillary carcinoma | Medium | convergence | {"qa_id":"medium_convergence_02911","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2A1 and MSH6 share multiple interacting partners. One such shared partner is described in a study stating: 'In this study, we show that each subunit of t... | |
medium_convergence_02912 | Human immunodeficiency virus 1 and Dengue virus both upregulate a shared gene. Evidence for one such shared gene reports a log2 fold change of 2.579 and an adjusted p-value of 0.01823. Which gene interacts with this shared entity? | STK4 | Medium | convergence | {"qa_id":"medium_convergence_02912","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human immunodeficiency virus 1 and Dengue virus both upregulate a shared gene. Evidence for one such shared gene reports a log2 fold change of 2.579 and an a... | |
medium_convergence_02914 | EGFR and ERBB2 both interact with a shared protein. Evidence indicates that this protein coprecipitates with activated epidermal growth factor and platelet-derived growth factor (PDGF) receptors, and that phosphorylated tyrosine residues on the PDGF receptor mediate its tyrosine phosphorylation. In which cell type is t... | memory B cell | Medium | convergence | {"qa_id":"medium_convergence_02914","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and ERBB2 both interact with a shared protein. Evidence indicates that this protein coprecipitates with activated epidermal growth factor and platelet-d... | |
medium_convergence_02915 | IFNAR2 and JAK1 both interact with a common protein. Evidence indicates that this protein binds to the cytoplasmic domain of the IFNAR2c (also known as IFNAR2-2) subunit of the IFN-alpha receptor in extracts of untreated cells. Which protein is encoded by the gene corresponding to this interacting entity? | Signal transducer and activator of transcription 2 | Medium | convergence | {"qa_id":"medium_convergence_02915","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IFNAR2 and JAK1 both interact with a common protein. Evidence indicates that this protein binds to the cytoplasmic domain of the IFNAR2c (also known as IFNAR... | |
medium_convergence_02916 | NR3C1 and BCAR1 each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'Furthermore, the association between p130(Cas) and the two zyxin family members was demonstrated to occur in vivo by co-immunoprecipitation.' Which protein is connected to that entity through the '... | Thyroid receptor-interacting protein 6 | Medium | convergence | {"qa_id":"medium_convergence_02916","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NR3C1 and BCAR1 each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'Furthermore, the association betwe... | |
medium_convergence_02917 | FYN and GRB2 both interact with a specific protein. Experimental evidence indicates that Src homology 3 domains from several Src family protein tyrosine kinases, including Lck, Abl, and Src, associate with this protein in vitro. Which protein is encoded by the gene corresponding to this interacting partner? | Disintegrin and metalloproteinase domain-containing protein 15 | Medium | convergence | {"qa_id":"medium_convergence_02917","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FYN and GRB2 both interact with a specific protein. Experimental evidence indicates that Src homology 3 domains from several Src family protein tyrosine kina... | |
medium_convergence_02918 | HDAC1 and HSF1 both interact with a common protein partner. Experimental evidence indicates that the regulatory domain of HSF1 (amino acids 212-380) interacts directly with amino acids 106-171 of this shared partner. Which protein is encoded by the gene corresponding to this shared partner? | Cell division cycle protein 20 homolog | Medium | convergence | {"qa_id":"medium_convergence_02918","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and HSF1 both interact with a common protein partner. Experimental evidence indicates that the regulatory domain of HSF1 (amino acids 212-380) interact... | |
medium_convergence_02919 | ESR1 and RB1 share common interaction partners. One such partner is supported by evidence stating: 'Co-immunoprecipitation assays confirmed that this partner interacts with SRC-1 and also demonstrated that this partner interacts with estrogen receptor alpha.' Which protein is encoded by the gene corresponding to this i... | E3 ubiquitin-protein ligase RBBP6 | Medium | convergence | {"qa_id":"medium_convergence_02919","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and RB1 share common interaction partners. One such partner is supported by evidence stating: 'Co-immunoprecipitation assays confirmed that this partner... | |
medium_convergence_02920 | SNF8 and CHMP2A each interact with more than one shared protein. Evidence concerning one of these shared entities reports that both EAP45 and EAP30 bind to the C-terminal domain of this entity, which is a component of ESCRT-I. Which protein is encoded by the gene corresponding to that entity? | Tumor susceptibility gene 101 protein | Medium | convergence | {"qa_id":"medium_convergence_02920","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SNF8 and CHMP2A each interact with more than one shared protein. Evidence concerning one of these shared entities reports that both EAP45 and EAP30 bind to t... | |
medium_convergence_02921 | PARP1 and MDM2 share multiple interacting partners. One such shared partner is described by the evidence: 'The protease responsible for the cleavage of poly(ADP-ribose) polymerase and necessary for apoptosis has been purified and characterized.' Which protein is encoded by this specific shared partner? | Caspase-3 | Medium | convergence | {"qa_id":"medium_convergence_02921","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and MDM2 share multiple interacting partners. One such shared partner is described by the evidence: 'The protease responsible for the cleavage of poly(... | |
medium_convergence_02922 | CREBBP and FBXW7 share multiple interaction partners. One such partner is a protein that is acetylated by CBP at lysine 146 and lysine 187, a modification that prevents the formation of a repressor complex. Which protein is encoded by the gene corresponding to this interaction partner? | Zinc finger protein SNAI1 | Medium | convergence | {"qa_id":"medium_convergence_02922","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and FBXW7 share multiple interaction partners. One such partner is a protein that is acetylated by CBP at lysine 146 and lysine 187, a modification th... | |
medium_convergence_02923 | XRCC6 and NR3C1 share multiple interacting partners. One such shared partner is supported by evidence stating that Ku proteins were identified as a transcription factor interacting protein via GST-pull down followed by mass spectrometry. Which protein encodes the entity described in this evidence? | Transcription factor AP-2-alpha | Medium | convergence | {"qa_id":"medium_convergence_02923","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"XRCC6 and NR3C1 share multiple interacting partners. One such shared partner is supported by evidence stating that Ku proteins were identified as a transcrip... | |
medium_convergence_02924 | POLR2E and POLR2I both interact with a shared protein. Evidence indicates that the interaction between this shared protein and RNA Polymerase II is direct and mediated by the RPB1 subunit. Which protein product is encoded by this shared protein? | ATP-dependent DNA helicase Q5 | Medium | convergence | {"qa_id":"medium_convergence_02924","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"POLR2E and POLR2I both interact with a shared protein. Evidence indicates that the interaction between this shared protein and RNA Polymerase II is direct an... | |
medium_convergence_02925 | SIRT1 and HMGA1 both interact with a specific protein. Evidence regarding this shared interaction partner states: 'In this report, we show that RARs interact in a ligand-dependent manner with HMG-I, which is known to displace histone H1 from chromatin.' Which protein is encoded by this shared interaction partner? | Retinoic acid receptor alpha | Medium | convergence | {"qa_id":"medium_convergence_02925","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIRT1 and HMGA1 both interact with a specific protein. Evidence regarding this shared interaction partner states: 'In this report, we show that RARs interact... | |
medium_convergence_02926 | AHCTF1 and BUB1 both interact with a specific protein. Research indicates that this protein contains an ABBA motif and binds to the APC/C coactivator. Which protein is encoded by the gene corresponding to this entity? | Cell division cycle protein 20 homolog | Medium | convergence | {"qa_id":"medium_convergence_02926","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AHCTF1 and BUB1 both interact with a specific protein. Research indicates that this protein contains an ABBA motif and binds to the APC/C coactivator. Which ... | |
medium_convergence_02927 | EIF3A and EIF3G both interact with a shared protein partner. Evidence regarding one such partner states: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 impairs translation in vivo.' Which protein is encoded by the gene corresponding to this specific partner? | Eukaryotic translation initiation factor 3 subunit M | Medium | convergence | {"qa_id":"medium_convergence_02927","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3A and EIF3G both interact with a shared protein partner. Evidence regarding one such partner states: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif... | |
medium_convergence_02928 | STUB1 and AGR2 both interact with a specific shared protein. Evidence indicates that this shared protein interacts with the chaperone-dependent E3 ligase CHIP, which plays a key role in its ubiquitination and degradation. Which protein is encoded by this shared entity? | Cytosolic 10-formyltetrahydrofolate dehydrogenase | Medium | convergence | {"qa_id":"medium_convergence_02928","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and AGR2 both interact with a specific shared protein. Evidence indicates that this shared protein interacts with the chaperone-dependent E3 ligase CHI... | |
medium_convergence_02929 | BUB3 and AURKB both interact with a shared protein entity. Evidence regarding this entity states: 'Here we report the identification of Dasra A and Dasra B, two new components of the vertebrate chromosomal passenger complex containing Incenp, Survivin, and the kinase Aurora B, and demonstrate that this complex is requi... | Borealin | Medium | convergence | {"qa_id":"medium_convergence_02929","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BUB3 and AURKB both interact with a shared protein entity. Evidence regarding this entity states: 'Here we report the identification of Dasra A and Dasra B, ... | |
medium_convergence_02930 | PSMD4 and UBE2L3 both interact with a common protein partner. Experimental evidence indicates that this partner forms a functional E3 ligase pair with UBE2L3 (acting as the E2 enzyme) to generate ubiquitin chains linked via lysine 48 (K48) and lysine 63 (K63) in vitro. Which protein product is encoded by this common pa... | Ubiquitin-protein ligase E3C | Medium | convergence | {"qa_id":"medium_convergence_02930","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PSMD4 and UBE2L3 both interact with a common protein partner. Experimental evidence indicates that this partner forms a functional E3 ligase pair with UBE2L3... | |
medium_convergence_02932 | Enoxacin and Ciprofloxacin both interact with a specific cation. Evidence suggests that this cation, along with calcium and probably zinc, interacts with these drugs in a similar manner. Which disease is this cation indicated for? | iron deficiency anemia | Medium | convergence | {"qa_id":"medium_convergence_02932","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Enoxacin and Ciprofloxacin both interact with a specific cation. Evidence suggests that this cation, along with calcium and probably zinc, interacts with the... | |
medium_convergence_02933 | Both Measles morbillivirus and Human mastadenovirus C are known to upregulate a specific shared gene. Experimental data for this gene indicates a log2 fold change of approximately 4.12 and an adjusted p-value of approximately 0.041. In which cellular component is this gene product located? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_02933","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Human mastadenovirus C are known to upregulate a specific shared gene. Experimental data for this gene indicates a log2 fold c... | |
medium_convergence_02934 | Human respirovirus 3 and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in non-small cell lung adenocarcinoma cells (study GSE147507) reports a log2 fold change of approximately 1.223 and an adjusted p-value of approximately 0.04216. In which cell type is this gene enriched? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_02934","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human respirovirus 3 and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in non-small cell lung adenocarcinoma cells (study... | |
medium_convergence_02935 | CDKN1C and HDAC1 both interact with a specific gene product. Evidence regarding this shared entity states: 'We report that overexpression of p57(Kip2) increased the half-life of [the protein encoded by the shared gene](Ala200). This increased half-life of [the protein encoded by the shared gene] involves a physical int... | Myoblast determination protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02935","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDKN1C and HDAC1 both interact with a specific gene product. Evidence regarding this shared entity states: 'We report that overexpression of p57(Kip2) increa... | |
medium_convergence_02936 | TRAF5 and TRAF6 both interact with a shared protein. Evidence indicates that for one of these shared partners, TRAF6 directly interacts with it via Lys48-linked polyubiquitination, thereby reducing the partner's protein levels in colorectal cancer cells. This reduction leads to necroptosis and promotes the proliferatio... | Receptor-interacting serine/threonine-protein kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_02936","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRAF5 and TRAF6 both interact with a shared protein. Evidence indicates that for one of these shared partners, TRAF6 directly interacts with it via Lys48-lin... | |
medium_convergence_02937 | Human alphaherpesvirus 1 and Human gammaherpesvirus 4 both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of -1.546 and an adjusted p-value of 0.002971. Which disease is associated with this gene through genomic alterations? | neurofibroma | Medium | convergence | {"qa_id":"medium_convergence_02937","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human gammaherpesvirus 4 both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (s... | |
medium_convergence_02938 | BMI1 and CBX2 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Using tandem affinity purification, we find that CBX7 and this shared entity, two Polycomb (Pc) homologs that repress INK4a, both participate in PRC1-like complexes with at least two Posterior sex combs (Psc) ... | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_02938","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMI1 and CBX2 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Using tandem affinity purification, we find th... | |
medium_convergence_02939 | SIN3A and HDAC1 share a common interaction partner. Evidence regarding one such partner states: 'This latter mutant can still homodimerize and bind to N-CoR but shows only weak binding to mSin3A.' Which disease is associated with this specific entity via a biomarker relationship? | systemic lupus erythematosus | Medium | convergence | {"qa_id":"medium_convergence_02939","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIN3A and HDAC1 share a common interaction partner. Evidence regarding one such partner states: 'This latter mutant can still homodimerize and bind to N-CoR ... | |
medium_convergence_02940 | RC3H1 and ESR1 share multiple interacting partners. One of these shared partners has a documented interaction with RC3H1 confirmed by Co-IP experiments. Which cellular component is this specific shared partner located in? | microtubule associated complex | Medium | convergence | {"qa_id":"medium_convergence_02940","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RC3H1 and ESR1 share multiple interacting partners. One of these shared partners has a documented interaction with RC3H1 confirmed by Co-IP experiments. Whic... | |
medium_convergence_02943 | Dengue virus and Cardiovirus A both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) shows a log2 fold change of -2.261 and an adjusted p-value of 0.02636. Which biological process is this gene involved in? | positive regulation of focal adhesion assembly | Medium | convergence | {"qa_id":"medium_convergence_02943","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Cardiovirus A both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) shows a log2 fold... | |
medium_convergence_02946 | CALCOCO2 and TRAF3IP2 both interact with a shared protein. Evidence indicates that IL-17 stimulation activated this shared protein and induced its association with Act1. Which disease is associated with this protein as a biomarker? | myelofibrosis | Medium | convergence | {"qa_id":"medium_convergence_02946","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CALCOCO2 and TRAF3IP2 both interact with a shared protein. Evidence indicates that IL-17 stimulation activated this shared protein and induced its associatio... | |
medium_convergence_02947 | TCF4 and TCF3 both interact with a specific shared protein. Experimental evidence indicates that yeast two-hybrid screening of a neuroblastoma cDNA library for proteins interacting with this shared entity identified it, along with numerous additional members of the E-protein family. Which protein is encoded by this sha... | Heart- and neural crest derivatives-expressed protein 2 | Medium | convergence | {"qa_id":"medium_convergence_02947","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TCF4 and TCF3 both interact with a specific shared protein. Experimental evidence indicates that yeast two-hybrid screening of a neuroblastoma cDNA library f... | |
medium_convergence_02948 | FAF1 and HSP90AA1 share a common interaction partner. Evidence regarding this shared partner states: 'Furthermore, we identify TbetaRI and TbetaRII as Hsp90-interacting proteins in vitro and in vivo.' Which protein is encoded by this shared interaction partner? | TGF-beta receptor type-2 | Medium | convergence | {"qa_id":"medium_convergence_02948","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FAF1 and HSP90AA1 share a common interaction partner. Evidence regarding this shared partner states: 'Furthermore, we identify TbetaRI and TbetaRII as Hsp90-... | |
medium_convergence_02950 | Both Human alphaherpesvirus 3 and Human immunodeficiency virus 1 are known to downregulate a specific shared gene. Experimental data from a melanoma cell line (study GSE136586) indicates that this gene exhibits a log2 fold change of approximately -1.169 and an adjusted p-value of 6.646e-05. Which protein does this gene... | MAP3K7 | Medium | convergence | {"qa_id":"medium_convergence_02950","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Human immunodeficiency virus 1 are known to downregulate a specific shared gene. Experimental data from a melanoma cell lin... | |
medium_convergence_02951 | FBXW11 and HDAC2 share multiple interacting partners. One such partner is identified by evidence stating: 'Using the sos recruitment yeast two-hybrid system we found that IRS-1 and histone deacetylase 2 interact in the cytoplasmic compartment of yeast cells.' Which disease is causally linked to this specific interactin... | hepatoblastoma | Medium | convergence | {"qa_id":"medium_convergence_02951","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FBXW11 and HDAC2 share multiple interacting partners. One such partner is identified by evidence stating: 'Using the sos recruitment yeast two-hybrid system ... | |
medium_convergence_02952 | PRKN (PARK2) and HIST1H2BH (H2BC9) share common interaction partners. Evidence indicates that Parkinson's disease-causing mutations in PARK2 disrupt its molecular interaction with specific TOMM complex subunits, including the surface receptor, a specific intermediate subunit, and the channel protein TOMM40. Which prote... | Mitochondrial import receptor subunit TOM70 | Medium | convergence | {"qa_id":"medium_convergence_02952","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKN (PARK2) and HIST1H2BH (H2BC9) share common interaction partners. Evidence indicates that Parkinson's disease-causing mutations in PARK2 disrupt its mole... | |
medium_convergence_02953 | COMMD1 and CUL3 both interact with a specific protein. Evidence regarding this protein states: 'To define the molecular basis for this assembly and the overall architecture of the E3, we determined the crystal structures of the BTB-BACK domains of [the protein] both alone and in complex with Cul3, along with the Kelch ... | proteasome-mediated ubiquitin-dependent protein catabolic process | Medium | convergence | {"qa_id":"medium_convergence_02953","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COMMD1 and CUL3 both interact with a specific protein. Evidence regarding this protein states: 'To define the molecular basis for this assembly and the overa... | |
medium_convergence_02954 | PARP1 and DDB1 share multiple interacting partners. One such shared partner is a protein that, when methylated at lysine 142 (K142), is bound by the methyl-binding protein L3MBTL3, which subsequently recruits a novel CRL4 complex. Which disease is associated with this specific shared partner via genomic alterations? | Ogden syndrome | Medium | convergence | {"qa_id":"medium_convergence_02954","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and DDB1 share multiple interacting partners. One such shared partner is a protein that, when methylated at lysine 142 (K142), is bound by the methyl-b... | |
medium_convergence_02955 | ATM and PRKDC share a common interacting partner. Evidence for one such partner states: 'We confirmed that this protein binds to a telomere maintenance protein also in mammalian cells, and this protein interacts with and stabilizes all six members of the PIKK family of proteins (mTOR, ATM, ATR, DNA-PKcs, SMG-1, and TRR... | TELO2 | Medium | convergence | {"qa_id":"medium_convergence_02955","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATM and PRKDC share a common interacting partner. Evidence for one such partner states: 'We confirmed that this protein binds to a telomere maintenance prote... | |
medium_convergence_02957 | Both sinoatrial node myocytes and atrioventricular node myocytes are subtypes of a specific cell class. Evidence regarding one such shared parent class describes it as 'A muscle cell that is part of the sinoatrial node.' Which broader cell type is this shared parent class a subtype of? | specialized cardiac myocyte | Medium | convergence | {"qa_id":"medium_convergence_02957","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both sinoatrial node myocytes and atrioventricular node myocytes are subtypes of a specific cell class. Evidence regarding one such shared parent class descr... | |
medium_convergence_02958 | CASP8 and IKBKE both interact with a shared protein. Evidence indicates that Caspase 8 interacts with multiple proteins involved in NF-kappaB pathway activation, specifically listing the serine-threonine kinases [shared entity], NIK, IKK1, and IKK2. Which protein, encoded by the gene corresponding to this shared entity... | Receptor-interacting serine/threonine-protein kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_02958","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CASP8 and IKBKE both interact with a shared protein. Evidence indicates that Caspase 8 interacts with multiple proteins involved in NF-kappaB pathway activat... | |
medium_convergence_02959 | Both Human immunodeficiency virus 1 and Dengue virus downregulate a specific gene. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately -1.30 and an adjusted p-value of 0.0068. Which biological process is this gene involved in? | regulation of endocytosis | Medium | convergence | {"qa_id":"medium_convergence_02959","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus downregulate a specific gene. In a study of macrophages (GSE108897), this gene exhibited a log2 fold cha... | |
medium_convergence_02960 | CREBBP and MEF2D both interact with a shared transcription factor. Evidence indicates that transcription factors of the nuclear factor of activated T cells (NFAT) family bind p300/CBP and recruit histone acetyltransferase activity from T cell nuclear extracts. Which disease is associated with this shared entity via a b... | pulmonary hypertension | Medium | convergence | {"qa_id":"medium_convergence_02960","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and MEF2D both interact with a shared transcription factor. Evidence indicates that transcription factors of the nuclear factor of activated T cells (... | |
medium_convergence_02961 | YAP1 and CCT2 share a common interaction partner. Evidence indicates that this shared partner interacts with YAP1 to enhance CTGF expression through histone methylation. Which disease is associated with this shared partner via genomic alterations? | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_02961","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and CCT2 share a common interaction partner. Evidence indicates that this shared partner interacts with YAP1 to enhance CTGF expression through histone ... | |
medium_convergence_02962 | CSNK2A1 and SIRT1 both interact with a shared protein. Evidence regarding one such shared partner indicates that the interaction between Nuclear CK2 and TAp73, confirmed by co-immunoprecipitation, was attenuated by a CK2 inhibitor or by a T27A point mutation at a predicted CK2 threonine phospho-acceptor site on TAp73. ... | Tumor protein p73 | Medium | convergence | {"qa_id":"medium_convergence_02962","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2A1 and SIRT1 both interact with a shared protein. Evidence regarding one such shared partner indicates that the interaction between Nuclear CK2 and TAp7... | |
medium_convergence_02963 | NR3C1 and AR each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'We have identified a corepressor as a hormone-dependent interaction partner of androgen receptor, a key transcription factor in the development of normal and cancerous prostate.' Which protein is connected... | BCL-6 corepressor | Medium | convergence | {"qa_id":"medium_convergence_02963","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NR3C1 and AR each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'We have identified a corepressor as a horm... | |
medium_convergence_02964 | CYLD and STX12 share multiple interacting partners. One such shared partner is involved in a process where Syntaxin 13, a t-SNARE required for endosome fusion, is transiently incorporated into large oligomers via direct interactions with this partner. Which protein is encoded by this shared interacting partner? | Early endosome antigen 1 | Medium | convergence | {"qa_id":"medium_convergence_02964","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CYLD and STX12 share multiple interacting partners. One such shared partner is involved in a process where Syntaxin 13, a t-SNARE required for endosome fusio... | |
medium_convergence_02965 | PDIA3 and TAP1 both interact with a shared protein partner. Experimental evidence indicates that only wild-type hTpn efficiently recruits heavy chain (HC) and calreticulin (Crt) into complexes with TAP and endoplasmic reticulum p57 (ERp57). Which disease is associated with this specific shared partner via genomic alter... | gastroschisis | Medium | convergence | {"qa_id":"medium_convergence_02965","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PDIA3 and TAP1 both interact with a shared protein partner. Experimental evidence indicates that only wild-type hTpn efficiently recruits heavy chain (HC) an... | |
medium_convergence_02966 | Both Human betaherpesvirus 5 and Rhinovirus A are associated with the upregulation of a specific gene. Experimental data for this gene in foreskin fibroblast cell lines reports a log2 fold change of approximately 1.514 and an adjusted p-value of 0.03007. Which protein is encoded by this gene? | THAP domain-containing protein 2 | Medium | convergence | {"qa_id":"medium_convergence_02966","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human betaherpesvirus 5 and Rhinovirus A are associated with the upregulation of a specific gene. Experimental data for this gene in foreskin fibroblast... | |
medium_convergence_02967 | Amikacin and Neomycin share a common drug interaction partner. Evidence indicates that a combination of Amikacin and this shared partner resulted in significantly lower numbers of colony-forming units in blood compared with individual antibiotics. Which drug is the shared interaction partner? | Picosulfuric acid | Medium | convergence | {"qa_id":"medium_convergence_02967","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Amikacin and Neomycin share a common drug interaction partner. Evidence indicates that a combination of Amikacin and this shared partner resulted in signific... | |
medium_convergence_02968 | GRB2 and NCK1 both interact with a specific shared protein. Evidence regarding this shared protein states: 'The new protein mainly binds to the proline-rich region of mDia through its Src homology 3 domain and also binds to Grb2 through its proline-rich domain.' Which protein is encoded by the gene corresponding to thi... | NCK-interacting protein with SH3 domain | Medium | convergence | {"qa_id":"medium_convergence_02968","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRB2 and NCK1 both interact with a specific shared protein. Evidence regarding this shared protein states: 'The new protein mainly binds to the proline-rich ... | |
medium_convergence_02969 | Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that this gene has a log2 fold change of approximately -1.377 and an adjusted p-value of 0.03558. Which protein is encoded by this gene? | Sterile alpha motif domain-containing protein 12 | Medium | convergence | {"qa_id":"medium_convergence_02969","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) ind... |
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