interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR001607 | 1,607 | Zinc finger, UBP-type | Znf_UBP | Domain | 40,230 | false | false | This entry represents UBP-type zinc finger domains, which display some similarity with the Zn-binding domain of the insulinase family. The UBP-type zinc finger domain is found only in a small subfamily of ubiquitin C-terminal hydrolases (deubiquitinases or UBP) [ , ], All members of this subfamily are isopeptidase-T, w... | [
"GO:0008270"
] | [
"zinc ion binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF02148",
"PS50271",
"SM00290"
] | [
"zf-UBP",
"ZF_UBP",
"ZnF_UBP"
] | [
39394,
39402,
26431
] | 3 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.4.19.12",
"PDOC50271",
"R-BTA-5689880",
"R-BTA-8948751",
"R-BTA-9010553",
"R-CEL-5673000",
"R-CEL-5675221",
"R-DDI-2151201",
"R-DDI-5689880",
"R-DDI-8866652",
"R-DDI-8948751",
"R-DME-1169408",
"R-DME-445989",
"R-DME-5689880",
"R-DME-9758274",
"R-DRE-5689880",
"R-DRE-5696395",
"R... | [
"EC:3.4.19.12",
"PROSITEDOC:PDOC50271",
"REACTOME:R-BTA-5689880",
"REACTOME:R-BTA-8948751",
"REACTOME:R-BTA-9010553",
"REACTOME:R-CEL-5673000",
"REACTOME:R-CEL-5675221",
"REACTOME:R-DDI-2151201",
"REACTOME:R-DDI-5689880",
"REACTOME:R-DDI-8866652",
"REACTOME:R-DDI-8948751",
"REACTOME:R-DME-1169... | 61 | [
"2g43",
"2g45",
"2i50",
"2ida",
"2l80",
"2uzg",
"3c5k",
"3gv4",
"3ihp",
"3jcr",
"3m99",
"3mhh",
"3mhs",
"3phd",
"4fip",
"4fjc",
"4fk5",
"4msx",
"4w4u",
"4wa6",
"4zux",
"5b8d",
"5g0f",
"5kh3",
"5kh7",
"5kh9",
"5wbn",
"5wpb",
"6ah0",
"6aqr",
"6ce6",
"6ce8"... | 72 | [
"PUB00005804",
"PUB00005830",
"PUB00014077",
"PUB00035804",
"PUB00035805",
"PUB00035806",
"PUB00035807",
"PUB00035812"
] | [
"9409543",
"9759494",
"12665246",
"17210253",
"15963892",
"15718139",
"10529348",
"11179890"
] | [
"Regulation of ubiquitin-dependent processes by deubiquitinating enzymes.",
"The ubiquitin system.",
"Zinc fingers--folds for many occasions.",
"Sticky fingers: zinc-fingers as protein-recognition motifs.",
"Multiple modes of RNA recognition by zinc finger proteins.",
"Zinc finger proteins: getting a grip... | [
1997,
1998,
2002,
2007,
2005,
2005,
1999,
2001
] | 8 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacillus phage vB_BceS-MY192",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
51,
1,
5539,
34624,
15
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
57,
8,
41,
33,
71,
41,
3,
17,
55,
4,
6,
44
] | 12 | true | Domain | Zinc finger, UBP-type | Zinc finger, UBP-type | Znf_UBP | 7 |
IPR001608 | 1,608 | Alanine racemase, N-terminal | Ala_racemase_N | Domain | 85,850 | false | false | Alanine racemase plays a role in providing the D-alanine required for cell wall biosynthesis by isomerising L-alanine to D-alanine. The molecular structure of alanine racemase from Bacillus stearothermophilus was determined by X-ray crystallography to a resolution of 1.9 A [ ]. The alanine racemase monomer is composed ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01168"
] | [
"Ala_racemase_N"
] | [
85850
] | 1 | [
"EC",
"EC",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"5.1.1",
"5.1.1.1",
"GenProp1593",
"PWY-7383",
"PWY-8040",
"PWY-8072",
"PWY-8443"
] | [
"EC:5.1.1",
"EC:5.1.1.1",
"GP:GenProp1593",
"METACYC:PWY-7383",
"METACYC:PWY-8040",
"METACYC:PWY-8072",
"METACYC:PWY-8443"
] | 7 | [
"1b54",
"1bd0",
"1ct5",
"1epv",
"1ftx",
"1l6f",
"1l6g",
"1niu",
"1rcq",
"1sft",
"1vfh",
"1vfs",
"1vft",
"1w8g",
"1xfc",
"1xqk",
"1xql",
"2dy3",
"2odo",
"2rjg",
"2rjh",
"2sfp",
"2vd8",
"2vd9",
"3anu",
"3anv",
"3awn",
"3awo",
"3b8t",
"3b8u",
"3b8v",
"3b8w"... | 113 | [
"PUB00000440"
] | [
"9063881"
] | [
"Determination of the structure of alanine racemase from Bacillus stearothermophilus at 1.9-A resolution."
] | [
1997
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
147,
76104,
6,
8026,
1567
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
8,
1,
2,
1,
4,
5,
5,
2,
5,
5,
2,
4,
7
] | 13 | true | Domain | Alanine racemase, N-terminal | Alanine racemase, N-terminal | Ala_racemase_N | 7 |
IPR001609 | 1,609 | Myosin head, motor domain-like | Myosin_head_motor_dom-like | Domain | 119,998 | false | false | Muscle contraction is caused by sliding between the thick and thin filaments of the myofibril. Myosin is a major component of thick filaments and exists as a hexamer of 2 heavy chains [ ], 2 alkali light chains, and 2 regulatory light chains. The heavy chain can be subdivided into the N-terminal globular head and the C... | [
"GO:0003774",
"GO:0005524",
"GO:0016459"
] | [
"cytoskeletal motor activity",
"ATP binding",
"myosin complex"
] | [
"molecular_function",
"molecular_function",
"cellular_component"
] | 3 | [
"PFAM",
"PRINTS",
"PROFILE",
"SMART"
] | [
"PF00063",
"PR00193",
"PS51456",
"SM00242"
] | [
"Myosin_head",
"MYOSINHEAVY",
"MYOSIN_MOTOR",
"MYSc"
] | [
117705,
98450,
118379,
110656
] | 4 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-2029482",
"R-BTA-5250924",
"R-BTA-5627123",
"R-CEL-2453902",
"R-CFA-2029482",
"R-DDI-5627123",
"R-DDI-9013418",
"R-DDI-9013419",
"R-DDI-9013420",
"R-DDI-9013422",
"R-DDI-9013425",
"R-DME-190873",
"R-DME-2453902",
"R-DME-350480",
"R-DME-445355",
"R-DME-5627123",
"R-DME-9013418"... | [
"REACTOME:R-BTA-2029482",
"REACTOME:R-BTA-5250924",
"REACTOME:R-BTA-5627123",
"REACTOME:R-CEL-2453902",
"REACTOME:R-CFA-2029482",
"REACTOME:R-DDI-5627123",
"REACTOME:R-DDI-9013418",
"REACTOME:R-DDI-9013419",
"REACTOME:R-DDI-9013420",
"REACTOME:R-DDI-9013422",
"REACTOME:R-DDI-9013425",
"REACTOM... | 105 | [
"1b7t",
"1br1",
"1br2",
"1br4",
"1d0x",
"1d0y",
"1d0z",
"1d1a",
"1d1b",
"1d1c",
"1dfk",
"1dfl",
"1fmv",
"1fmw",
"1g8x",
"1i84",
"1jwy",
"1jx2",
"1kk7",
"1kk8",
"1kqm",
"1kwo",
"1l2o",
"1lkx",
"1lvk",
"1m8q",
"1mma",
"1mmd",
"1mmg",
"1mmn",
"1mnd",
"1mne"... | 256 | [
"PUB00001579",
"PUB00002350",
"PUB00004601",
"PUB00004629",
"PUB00005168",
"PUB00005169",
"PUB00155058",
"PUB00155059"
] | [
"2806546",
"1939027",
"6576334",
"3540939",
"8316857",
"8316858",
"22964252",
"31681248"
] | [
"Human embryonic myosin heavy chain cDNA. Interspecies sequence conservation of the myosin rod, chromosomal locus and isoform specific transcription of the gene.",
"The primary structure of skeletal muscle myosin heavy chain: I. Sequence of the amino-terminal 23 kDa fragment.",
"Protein structural domains in th... | [
1989,
1991,
1983,
1986,
1993,
1993,
2012,
2019
] | 8 | [] | [
"IPR036000",
"IPR036018",
"IPR036022",
"IPR036023",
"IPR036029",
"IPR036035",
"IPR036037",
"IPR036042",
"IPR036044",
"IPR036057",
"IPR036064",
"IPR036072",
"IPR036083",
"IPR036103",
"IPR036106",
"IPR036114",
"IPR036124",
"IPR036125",
"IPR042702"
] | 0 | 19 | 0 | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
10,
119984,
4
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
128,
28,
440,
71,
226,
146,
5,
58,
205,
5,
5,
247
] | 12 | true | Domain | Myosin head, motor domain-like | Myosin head, motor domain-like | Myosin_head_motor_dom-like | 9 |
IPR001610 | 1,610 | PAC motif | PAC | Repeat | 192,891 | false | false | PAC motifs occur C-terminal to a subset of all known PAS motifs (see ). It is proposed to contribute to the PAS domain fold [ , , ]. | [] | [] | [] | 0 | [
"SMART"
] | [
"SM00086"
] | [
"PAC"
] | [
192891
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1296072",
"R-CFA-1296072",
"R-CFA-5576890",
"R-DME-1234158",
"R-DME-1234176",
"R-DME-432395",
"R-DME-432408",
"R-DME-432501",
"R-DME-432524",
"R-DME-432560",
"R-DME-432620",
"R-DME-432626",
"R-DME-8951664",
"R-DRE-211945",
"R-DRE-211976",
"R-DRE-211981",
"R-DRE-8937144",
"R-... | [
"REACTOME:R-BTA-1296072",
"REACTOME:R-CFA-1296072",
"REACTOME:R-CFA-5576890",
"REACTOME:R-DME-1234158",
"REACTOME:R-DME-1234176",
"REACTOME:R-DME-432395",
"REACTOME:R-DME-432408",
"REACTOME:R-DME-432501",
"REACTOME:R-DME-432524",
"REACTOME:R-DME-432560",
"REACTOME:R-DME-432620",
"REACTOME:R-DM... | 74 | [
"1byw",
"1n9l",
"1n9n",
"1n9o",
"1p97",
"1v9y",
"1v9z",
"1vb6",
"1x0o",
"2a24",
"2b02",
"2gj3",
"2hv1",
"2k7s",
"2l0w",
"2l1m",
"2l4r",
"2mwg",
"2pr5",
"2pr6",
"2v0u",
"2v0w",
"2v1a",
"2v1b",
"2wkp",
"2wkq",
"2wkr",
"2z6c",
"2z6d",
"3ewk",
"3f1n",
"3f1o"... | 277 | [
"PUB00000420",
"PUB00005472",
"PUB00006196"
] | [
"7756254",
"9301332",
"9382818"
] | [
"1.4 A structure of photoactive yellow protein, a cytosolic photoreceptor: unusual fold, active site, and chromophore.",
"PAS domain S-boxes in Archaea, Bacteria and sensors for oxygen and redox.",
"PAS: a multifunctional domain family comes to light."
] | [
1995,
1997,
1997
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
7652,
146355,
36869,
5,
2010
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
50,
6,
115,
29,
3,
69,
47,
4,
14,
81,
2,
17
] | 12 | true | Repeat | PAC motif | PAC motif | PAC | 1 |
IPR001611 | 1,611 | Leucine-rich repeat | Leu-rich_rpt | Repeat | 742,797 | false | false | Leucine-rich repeats (LRR) consist of 2-45 motifs of 20-30 amino acids in length that generally folds into an arc or horseshoe shape [ ]. LRRs occur in proteins ranging from viruses to eukaryotes, and appear to provide a structural framework for the formation of protein-protein interactions [ , ].Proteins containing LR... | [
"GO:0005515"
] | [
"protein binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PFAM",
"PFAM",
"PROFILE"
] | [
"PF00560",
"PF13516",
"PF13855",
"PS51450"
] | [
"LRR_1",
"LRR_6",
"LRR_8",
"LRR"
] | [
290055,
135897,
409339,
432743
] | 4 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-114608",
"R-BTA-1474228",
"R-BTA-159227",
"R-BTA-159230",
"R-BTA-159231",
"R-BTA-159236",
"R-BTA-168142",
"R-BTA-168638",
"R-BTA-1971475",
"R-BTA-2022854",
"R-BTA-2022857",
"R-BTA-2022870",
"R-BTA-2022923",
"R-BTA-2024101",
"R-BTA-216083",
"R-BTA-3000178",
"R-BTA-450302",
"R... | [
"REACTOME:R-BTA-114608",
"REACTOME:R-BTA-1474228",
"REACTOME:R-BTA-159227",
"REACTOME:R-BTA-159230",
"REACTOME:R-BTA-159231",
"REACTOME:R-BTA-159236",
"REACTOME:R-BTA-168142",
"REACTOME:R-BTA-168638",
"REACTOME:R-BTA-1971475",
"REACTOME:R-BTA-2022854",
"REACTOME:R-BTA-2022857",
"REACTOME:R-BTA... | 599 | [
"1a4y",
"1a9n",
"1d0b",
"1dce",
"1dfj",
"1ds9",
"1fo1",
"1ft8",
"1g9u",
"1gwb",
"1h6t",
"1h6u",
"1jl5",
"1koh",
"1koo",
"1ltx",
"1m0z",
"1m10",
"1m9l",
"1m9s",
"1o6s",
"1o6t",
"1o6v",
"1ogq",
"1ook",
"1otm",
"1otn",
"1oto",
"1ozn",
"1p8t",
"1p8v",
"1p9a"... | 818 | [
"PUB00001625",
"PUB00001898",
"PUB00007147",
"PUB00007148",
"PUB00017058",
"PUB00094376"
] | [
"1657640",
"2176636",
"11751054",
"11967365",
"14747988",
"21606681"
] | [
"A leucine-rich repeat peptide derived from the Drosophila Toll receptor forms extended filaments with a beta-sheet structure.",
"slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains.",
"The leucine-rich repeat as a protein reco... | [
1991,
1990,
2001,
2002,
2004,
2011
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
153,
24891,
715902,
468,
1383
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
2299,
88,
1850,
387,
1,
926,
662,
15,
1672,
933,
13,
10,
1859
] | 13 | true | Repeat | Leucine-rich repeat | Leucine-rich repeat | Leu-rich_rpt | 6 |
IPR001612 | 1,612 | Caveolin | Caveolin | Family | 4,290 | false | false | Caveolae are 50-100 nm invaginations located at the plasma membrane of many cell types and are known to transport molecules across endothelial cells [ ]. Caveolae require the caveolin protein for formation. Caveolins may act as scaffolding proteins within caveolar membranes by compartmentalizing and concentrating signa... | [
"GO:0070836"
] | [
"caveola assembly"
] | [
"biological_process"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF01146",
"PTHR10844"
] | [
"Caveolin",
""
] | [
4290,
4221
] | 2 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00930",
"R-BTA-203615",
"R-BTA-203641",
"R-BTA-210991",
"R-BTA-4641262",
"R-BTA-5218920",
"R-BTA-8980692",
"R-BTA-9009391",
"R-BTA-9013106",
"R-BTA-9013148",
"R-BTA-9013149",
"R-BTA-9013404",
"R-BTA-9013405",
"R-BTA-9013406",
"R-BTA-9013407",
"R-BTA-9013408",
"R-BTA-9013423",
... | [
"PROSITEDOC:PDOC00930",
"REACTOME:R-BTA-203615",
"REACTOME:R-BTA-203641",
"REACTOME:R-BTA-210991",
"REACTOME:R-BTA-4641262",
"REACTOME:R-BTA-5218920",
"REACTOME:R-BTA-8980692",
"REACTOME:R-BTA-9009391",
"REACTOME:R-BTA-9013106",
"REACTOME:R-BTA-9013148",
"REACTOME:R-BTA-9013149",
"REACTOME:R-B... | 121 | [
"7sc0",
"9dn0",
"9dn1"
] | 3 | [
"PUB00074862",
"PUB00074863"
] | [
"9759488",
"23028656"
] | [
"The caveolae membrane system.",
"Evaluating caveolin interactions: do proteins interact with the caveolin scaffolding domain through a widespread aromatic residue-rich motif?"
] | [
1998,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Opisthokonta",
"marine sediment metagenome"
] | [
4289,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
7,
12,
8,
15
] | 5 | true | Family | Caveolin | Caveolin | Caveolin | 3 |
IPR001613 | 1,613 | Flavin amine oxidase | Flavin_amine_oxidase | Family | 22,893 | false | false | Monoamine oxidases (MAO) A and B are encoded by two genes derived from a common ancestral gene [ ]. The enzymes catalyse the oxidative deamination of biogenic and xenobiotic amines and have important roles in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues [ ]. M... | [
"GO:0016491"
] | [
"oxidoreductase activity"
] | [
"molecular_function"
] | 1 | [
"PRINTS"
] | [
"PR00757"
] | [
"AMINEOXDASEF"
] | [
22893
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"1.4.3",
"R-BTA-141333",
"R-BTA-181430",
"R-BTA-379397",
"R-BTA-379398",
"R-BTA-379401",
"R-BTA-380612",
"R-CFA-141333",
"R-DDI-141333",
"R-DDI-181430",
"R-DDI-379397",
"R-DDI-379398",
"R-DDI-379401",
"R-DDI-380612",
"R-DRE-141333",
"R-HSA-141333",
"R-HSA-181430",
"R-HSA-379397",
... | [
"EC:1.4.3",
"REACTOME:R-BTA-141333",
"REACTOME:R-BTA-181430",
"REACTOME:R-BTA-379397",
"REACTOME:R-BTA-379398",
"REACTOME:R-BTA-379401",
"REACTOME:R-BTA-380612",
"REACTOME:R-CFA-141333",
"REACTOME:R-DDI-141333",
"REACTOME:R-DDI-181430",
"REACTOME:R-DDI-379397",
"REACTOME:R-DDI-379398",
"REAC... | 37 | [
"1b37",
"1b5q",
"1gos",
"1h81",
"1h82",
"1h83",
"1h84",
"1h86",
"1o5w",
"1oj9",
"1oja",
"1ojc",
"1ojd",
"1reo",
"1s2q",
"1s2y",
"1s3b",
"1s3e",
"1tdk",
"1tdn",
"1tdo",
"2bk3",
"2bk4",
"2bk5",
"2bxr",
"2bxs",
"2byb",
"2c64",
"2c65",
"2c66",
"2c67",
"2c70"... | 141 | [
"PUB00003451",
"PUB00003462",
"PUB00004658"
] | [
"3418353",
"1432104",
"3387449"
] | [
"Structural features of human monoamine oxidase A elucidated from cDNA and peptide sequences.",
"Promoter organization and activity of human monoamine oxidase (MAO) A and B genes.",
"cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties."
] | [
1988,
1992,
1988
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Tupanvirus",
"unclassified sequences"
] | [
70,
10339,
12397,
4,
83
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
20,
6,
11,
14,
1,
5,
15,
32
] | 8 | true | Family | Flavin amine oxidase | Flavin amine oxidase | Flavin_amine_oxidase | 7 |
IPR001614 | 1,614 | Myelin proteolipid protein PLP | Myelin_PLP | Family | 6,182 | false | false | The myelin sheath is a multi-layered membrane, unique to the nervous system, that functions as an insulator to greatly increase the velocity of axonal impulse conduction [ ]. Myelin proteolipid protein (PLP or lipophilin) [ ] is the major myelin protein from the central nervous system (CNS). It probably plays an import... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PFAM",
"PRINTS",
"PANTHER",
"SMART"
] | [
"PF01275",
"PR00214",
"PTHR11683",
"SM00002"
] | [
"Myelin_PLP",
"MYELINPLP",
"",
"PLP"
] | [
6035,
4832,
5996,
4782
] | 4 | [
"PROSITEDOC"
] | [
"PDOC00497"
] | [
"PROSITEDOC:PDOC00497"
] | 1 | [] | 0 | [
"PUB00000360",
"PUB00000749",
"PUB00002447",
"PUB00003190",
"PUB00004311"
] | [
"1281423",
"1722981",
"2435734",
"1711121",
"8398137"
] | [
"Proteolipid protein (PLP) of CNS myelin: positions of free, disulfide-bonded, and fatty acid thioester-linked cysteine residues and implications for the membrane topology of PLP.",
"Evolution of the myelin integral membrane proteins of the central nervous system.",
"Complete amino acid sequence of PO protein i... | [
1992,
1991,
1987,
1991,
1993
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
5,
6177
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
19,
6,
36,
11,
24
] | 6 | true | Family | Myelin proteolipid protein PLP | Myelin proteolipid protein PLP | Myelin_PLP | 3 |
IPR001615 | 1,615 | Delta-endotoxin CytB | Endotoxin_CytB | Family | 352 | false | false | Bacillus thuringiensis produces the delta-endotoxin CytB, a membrane pore-forming protein, which is active against insects [ ]. The toxin kills the larvae of dipteran insects by making pores in the epithelial cell membrane of the insect midgut. The crystal protein is produced during sporulation and is accumulated both ... | [
"GO:0005576"
] | [
"extracellular region"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF01338"
] | [
"Bac_thur_toxin"
] | [
352
] | 1 | [] | [] | [] | 0 | [
"1cby",
"1pp0",
"1pp6",
"1vcy",
"1vgf",
"2mlw",
"2rci",
"3ron",
"6t14",
"6t19",
"6t1a",
"6t1c"
] | 12 | [
"PUB00003358"
] | [
"8632451"
] | [
"Structure of the mosquitocidal delta-endotoxin CytB from Bacillus thuringiensis sp. kyushuensis and implications for membrane pore formation."
] | [
1996
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
253,
99
] | 2 | [] | [] | 0 | true | Family | Delta-endotoxin CytB | Delta-endotoxin CytB | Endotoxin_CytB | 9 |
IPR001616 | 1,616 | Alphaherpesvirus alkaline exonuclease | Herpes_alk_exo | Family | 504 | false | false | This entry includes an alkaline nuclease (product of the UL98 gene) from herpesviruses. The nuclease acts as both an endo-and an exonuclease, and accepts both single-and double-stranded DNA as substrates. DNA is digested in the 5'->3' direction to produce 5'-monophosphate nucleosides. The nuclease activity results in t... | [
"GO:0003677",
"GO:0004527"
] | [
"DNA binding",
"exonuclease activity"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"HAMAP",
"PRINTS"
] | [
"MF_04009",
"PR00924"
] | [
"HSV_AN",
"ALKEXNUCLASE"
] | [
472,
504
] | 2 | [
"REACTOME"
] | [
"R-HSA-9609690"
] | [
"REACTOME:R-HSA-9609690"
] | 1 | [
"2w45",
"2w4b",
"3fhd",
"3pov",
"5hsw"
] | 5 | [
"PUB00084219"
] | [
"9367383"
] | [
"The human cytomegalovirus UL98 gene encodes the conserved herpesvirus alkaline nuclease."
] | [
1997
] | 1 | [
"IPR034720"
] | [] | 1 | 0 | 1 | [
"Eumetazoa",
"Orthoherpesviridae"
] | [
23,
481
] | 2 | [
"Homo sapiens"
] | [
1
] | 1 | true | Family | Alphaherpesvirus alkaline exonuclease | Alphaherpesvirus alkaline exonuclease | Herpes_alk_exo | 1 |
IPR001619 | 1,619 | Sec1-like protein | Sec1-like | Family | 31,918 | false | false | Sec1-like molecules have been implicated in a variety of eukaryotic vesicle transport processes including neurotransmitter release by exocytosis [ ]. They regulate vesicle transport by binding to a t-SNARE from the syntaxin family. This process is thought to prevent SNARE complex formation, a protein complex required f... | [
"GO:0016192"
] | [
"vesicle-mediated transport"
] | [
"biological_process"
] | 1 | [
"PFAM",
"PIRSF",
"PANTHER"
] | [
"PF00995",
"PIRSF005715",
"PTHR11679"
] | [
"Sec1",
"VPS45_Sec1",
""
] | [
30407,
18669,
30713
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-181429",
"R-BTA-181430",
"R-BTA-210500",
"R-BTA-212676",
"R-BTA-264642",
"R-BTA-888590",
"R-CEL-114516",
"R-CEL-114608",
"R-CEL-181429",
"R-CEL-181430",
"R-CEL-210500",
"R-CEL-212676",
"R-CEL-264642",
"R-CEL-449836",
"R-CEL-888590",
"R-DDI-114516",
"R-DDI-114608",
"R-DDI-204... | [
"REACTOME:R-BTA-181429",
"REACTOME:R-BTA-181430",
"REACTOME:R-BTA-210500",
"REACTOME:R-BTA-212676",
"REACTOME:R-BTA-264642",
"REACTOME:R-BTA-888590",
"REACTOME:R-CEL-114516",
"REACTOME:R-CEL-114608",
"REACTOME:R-CEL-181429",
"REACTOME:R-CEL-181430",
"REACTOME:R-CEL-210500",
"REACTOME:R-CEL-212... | 84 | [
"1epu",
"1fvf",
"1fvh",
"1mqs",
"1y9j",
"2xhe",
"3c98",
"3puj",
"3puk",
"4bx8",
"4bx9",
"4cca",
"4jc8",
"4jeh",
"4jeu",
"4kmo",
"5buz",
"5bv0",
"5bv1",
"6lpc",
"6xjl",
"6xm1",
"6xmd",
"7udb",
"7udc",
"7xsj",
"7zu0",
"8dit",
"8qx8"
] | 29 | [
"PUB00003457",
"PUB00007149"
] | [
"8769846",
"10903948"
] | [
"The Sec1 family: a novel family of proteins involved in synaptic transmission and general secretion.",
"The X-ray crystal structure of neuronal Sec1 from squid sheds new light on the role of this protein in exocytosis."
] | [
1996,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Mimiviridae",
"viral metagenome"
] | [
31894,
23,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
36,
7,
13,
9,
123,
29,
4,
29,
38,
4,
4,
54
] | 12 | true | Family | Sec1-like protein | Sec1-like protein | Sec1-like | 1 |
IPR001620 | 1,620 | Dopamine D3 receptor | Dopamine_D3_rcpt | Family | 652 | false | false | Dopamine receptors are members of the rhodopsin-like G-protein coupled receptor family and are prominent in the vertebrate central nervous system (CNS). Dysfunction of dopaminergic neurotransmission in the CNS has been implicated in a variety of neuropsychiatric disorders [ ], including social phobia [ ], Tourette's sy... | [
"GO:0004952",
"GO:0007195",
"GO:0005886"
] | [
"dopamine neurotransmitter receptor activity",
"adenylate cyclase-inhibiting dopamine receptor signaling pathway",
"plasma membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR00568"
] | [
"DOPAMINED3R"
] | [
652
] | 1 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"216",
"R-HSA-390651",
"R-HSA-418594",
"R-MMU-390651",
"R-MMU-418594",
"R-RNO-390651",
"R-RNO-418594"
] | [
"IUPHAR:216",
"REACTOME:R-HSA-390651",
"REACTOME:R-HSA-418594",
"REACTOME:R-MMU-390651",
"REACTOME:R-MMU-418594",
"REACTOME:R-RNO-390651",
"REACTOME:R-RNO-418594"
] | 7 | [
"7cmu",
"7cmv",
"8irt"
] | 3 | [
"PUB00064281",
"PUB00064282",
"PUB00064283",
"PUB00064284",
"PUB00064285",
"PUB00064286",
"PUB00064287",
"PUB00064288",
"PUB00064289",
"PUB00064290",
"PUB00064291",
"PUB00064292",
"PUB00064293",
"PUB00064310",
"PUB00064311",
"PUB00064312",
"PUB00067001",
"PUB00067009"
] | [
"15148138",
"10698826",
"16613557",
"17017512",
"12555236",
"16961425",
"11920678",
"9633679",
"16433053",
"14060771",
"1060115",
"12836695",
"9457173",
"17013922",
"16982285",
"10596903",
"16458973",
"8099761"
] | [
"The neurobiology of dopamine signaling.",
"Low dopamine D(2) receptor binding potential in social phobia.",
"Dopamine and the diseased brain.",
"The nigrostriatal DA pathway and Parkinson's disease.",
"Relationship between functional dopamine D2 and D3 receptors gene polymorphisms and neuroleptic malignant... | [
2004,
2000,
2006,
2006,
2003,
2006,
2002,
1998,
2005,
1963,
1975,
2003,
1998,
2006,
2006,
1999,
2006,
1993
] | 18 | [
"IPR000929"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
652
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
3,
3
] | 3 | true | Family | Dopamine D3 receptor | Dopamine D3 receptor | Dopamine_D3_rcpt | 6 |
IPR001621 | 1,621 | Fungal ligninase | Ligninase | Family | 3,342 | false | false | Peroxidases are haem-containing enzymes that use hydrogen peroxide as the electron acceptor to catalyse a number of oxidative reactions. Peroxidases are found in bacteria, fungi, plants and animals. Fungal ligninases are extracellular haem enzymes involved in the degradation of lignin. They include lignin peroxidases (... | [
"GO:0004601",
"GO:0020037",
"GO:0006979"
] | [
"peroxidase activity",
"heme binding",
"response to oxidative stress"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PRINTS",
"CDD"
] | [
"PR00462",
"cd00692"
] | [
"LIGNINASE",
"ligninase"
] | [
3339,
1079
] | 2 | [
"EC"
] | [
"1.11.1"
] | [
"EC:1.11.1"
] | 1 | [
"1arp",
"1aru",
"1arv",
"1arw",
"1arx",
"1ary",
"1b80",
"1b82",
"1b85",
"1c8i",
"1ck6",
"1gza",
"1gzb",
"1h3j",
"1hsr",
"1lga",
"1llp",
"1ly8",
"1ly9",
"1lyc",
"1lyk",
"1mn1",
"1mn2",
"1mnp",
"1qpa",
"1yyd",
"1yyg",
"1yzp",
"1yzr",
"2boq",
"2e39",
"2e3a"... | 76 | [
"PUB00001743",
"PUB00002822",
"PUB00002886",
"PUB00003315",
"PUB00005246",
"PUB00028246"
] | [
"8167033",
"8440725",
"7806497",
"8289254",
"7922023",
"10187820"
] | [
"Physiology and molecular biology of the lignin peroxidases of Phanerochaete chrysosporium.",
"Crystallographic refinement of lignin peroxidase at 2 A.",
"The crystal structure of manganese peroxidase from Phanerochaete chrysosporium at 2.06-A resolution.",
"Crystal structure of the fungal peroxidase from Art... | [
1994,
1993,
1994,
1994,
1994,
1999
] | 6 | [
"IPR044831"
] | [] | 1 | 0 | 1 | [
"Eukaryota",
"Pseudomonas nunensis"
] | [
3341,
1
] | 2 | [] | [] | 0 | true | Family | Fungal ligninase | Fungal ligninase | Ligninase | 3 |
IPR001623 | 1,623 | DnaJ domain | DnaJ_domain | Domain | 303,513 | false | false | null | [] | [] | [] | 0 | [
"PFAM",
"PRINTS",
"PROFILE",
"SMART",
"CDD"
] | [
"PF00226",
"PR00625",
"PS50076",
"SM00271",
"cd06257"
] | [
"DnaJ",
"JDOMAIN",
"DNAJ_2",
"DnaJ",
"DnaJ"
] | [
267227,
232146,
292802,
274116,
290002
] | 5 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00553",
"R-BTA-3371453",
"R-BTA-3371497",
"R-BTA-3371568",
"R-BTA-3371571",
"R-BTA-5687128",
"R-BTA-6798695",
"R-BTA-888590",
"R-BTA-9841251",
"R-CFA-418359",
"R-CFA-425561",
"R-CFA-5578775",
"R-DDI-3371497",
"R-DDI-6798695",
"R-DME-6798695",
"R-DME-888590",
"R-DRE-3371453",
"... | [
"PROSITEDOC:PDOC00553",
"REACTOME:R-BTA-3371453",
"REACTOME:R-BTA-3371497",
"REACTOME:R-BTA-3371568",
"REACTOME:R-BTA-3371571",
"REACTOME:R-BTA-5687128",
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-888590",
"REACTOME:R-BTA-9841251",
"REACTOME:R-CFA-418359",
"REACTOME:R-CFA-425561",
"REACTOME:R-C... | 84 | [
"1bq0",
"1bqz",
"1faf",
"1fpo",
"1gh6",
"1hdj",
"1iur",
"1n4c",
"1nz6",
"1wjz",
"1xbl",
"1xi5",
"2ctp",
"2ctq",
"2ctr",
"2ctw",
"2cug",
"2dmx",
"2dn9",
"2ej7",
"2guz",
"2kqx",
"2l6l",
"2lgw",
"2lo1",
"2m6y",
"2n04",
"2n05",
"2och",
"2pf4",
"2qsa",
"2qwn"... | 131 | [
"PUB00003367",
"PUB00005384",
"PUB00020790",
"PUB00033831",
"PUB00033832"
] | [
"8764403",
"1585456",
"15170475",
"11395418",
"12454054"
] | [
"NMR structure of the J-domain and the Gly/Phe-rich region of the Escherichia coli DnaJ chaperone.",
"A module of the DnaJ heat shock proteins found in malaria parasites.",
"The J-protein family: modulating protein assembly, disassembly and translocation.",
"Folding of newly translated proteins in vivo: the r... | [
1996,
1992,
2004,
2001,
2002
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
2260,
83918,
213698,
1263,
2374
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
523,
43,
228,
89,
5,
185,
152,
28,
306,
237,
21,
24,
657
] | 13 | true | Domain | DnaJ domain | DnaJ domain | DnaJ_domain | 8 |
IPR001624 | 1,624 | Flagellar hook-basal body complex protein FliE | FliE | Family | 13,126 | false | false | Four genes from the major Bacillus subtilis chemotaxis locus have been shown to encode proteins that are similar to the Salmonella typhimurium FlgB, FlgC, FlgG and FliF proteins; a further gene product is similar to the Escherichia coli FliE protein [ ]. All of these proteins are thought to form part of the hook-basal ... | [
"GO:0003774",
"GO:0005198",
"GO:0071973",
"GO:0009288"
] | [
"cytoskeletal motor activity",
"structural molecule activity",
"bacterial-type flagellum-dependent cell motility",
"bacterial-type flagellum"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"HAMAP",
"PFAM",
"PRINTS",
"PANTHER",
"NCBIFAM"
] | [
"MF_00724",
"PF02049",
"PR01006",
"PTHR34653",
"TIGR00205"
] | [
"FliE",
"FliE",
"FLGHOOKFLIE",
"",
"fliE"
] | [
12220,
13122,
10858,
12894,
10125
] | 5 | [
"GP"
] | [
"GenProp0880"
] | [
"GP:GenProp0880"
] | 1 | [
"7bin",
"7cg4",
"7cgo",
"7e80",
"7e82",
"7nvg",
"8wk3",
"8wk4",
"8wkk",
"8wkq",
"8wl2",
"8wlh",
"8wln",
"8wlq",
"8wlt",
"8wo5",
"8woe",
"8z5s",
"8z5u",
"8z5x",
"8z60"
] | 21 | [
"PUB00001805",
"PUB00002168"
] | [
"1905667",
"1551848"
] | [
"Gene-protein relationships in the flagellar hook-basal body complex of Bacillus subtilis: sequences of the flgB, flgC, flgG, fliE and fliF genes.",
"Characterization of the fliE genes of Escherichia coli and Salmonella typhimurium and identification of the FliE protein as a component of the flagellar hook-basal ... | [
1991,
1992
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
12952,
16,
158
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Flagellar hook-basal body complex protein FliE | Flagellar hook-basal body complex protein FliE | FliE | 9 |
IPR001626 | 1,626 | ABC transporter, TroCD-like | ABC_TroCD | Family | 39,853 | false | false | Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters are involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two transmembrane regions (TMs), and two cytoplasmic ABCs, and are mainly involved in... | [
"GO:0055085",
"GO:0005886",
"GO:0043190"
] | [
"transmembrane transport",
"plasma membrane",
"ATP-binding cassette (ABC) transporter complex"
] | [
"biological_process",
"cellular_component",
"cellular_component"
] | 3 | [
"PFAM",
"PANTHER"
] | [
"PF00950",
"PTHR30477"
] | [
"ABC-3",
""
] | [
39829,
39630
] | 2 | [
"REACTOME"
] | [
"R-HSA-9638482"
] | [
"REACTOME:R-HSA-9638482"
] | 1 | [
"7kyo",
"7kyp"
] | 2 | [
"PUB00026953",
"PUB00049009",
"PUB00070765",
"PUB00078715",
"PUB00080123",
"PUB00080128",
"PUB00080129",
"PUB00080135",
"PUB00088718"
] | [
"12004122",
"17673622",
"11421271",
"17581125",
"11421276",
"2823072",
"9802017",
"9332349",
"9440518"
] | [
"The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism.",
"Asymmetry in the structure of the ABC transporter-binding protein complex BtuCD-BtuF.",
"A new family of high-affinity ABC manganese and zinc permeases.",
"The general transition metal (Tro) and Zn2+ (Znu) transporter... | [
2002,
2007,
2001,
2007,
2001,
1987,
1998,
1997,
1998
] | 9 | [] | [
"IPR022392"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
912,
38388,
8,
48,
497
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | ABC transporter, TroCD-like | ABC transporter, TroCD-like | ABC_TroCD | 7 |
IPR001627 | 1,627 | Sema domain | Semap_dom | Domain | 54,214 | false | false | The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in plexins [ ], receptors for multiple classes of semaphorins, in hepatocyte growth factor receptor, and in viral proteins [ ]... | [
"GO:0005515"
] | [
"protein binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF01403",
"PS51004",
"SM00630"
] | [
"Sema",
"SEMA",
"Sema"
] | [
50244,
53718,
50386
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC51004",
"R-CEL-399954",
"R-CEL-399955",
"R-CEL-399956",
"R-CEL-416482",
"R-CEL-416550",
"R-CEL-416572",
"R-CEL-416700",
"R-CEL-9013405",
"R-DME-399954",
"R-DME-399955",
"R-DME-399956",
"R-DME-416482",
"R-DME-416572",
"R-DME-416700",
"R-DME-5173214",
"R-DME-9013405",
"R-DRE-399... | [
"PROSITEDOC:PDOC51004",
"REACTOME:R-CEL-399954",
"REACTOME:R-CEL-399955",
"REACTOME:R-CEL-399956",
"REACTOME:R-CEL-416482",
"REACTOME:R-CEL-416550",
"REACTOME:R-CEL-416572",
"REACTOME:R-CEL-416700",
"REACTOME:R-CEL-9013405",
"REACTOME:R-DME-399954",
"REACTOME:R-DME-399955",
"REACTOME:R-DME-399... | 116 | [
"1olz",
"1q47",
"1shy",
"2uzx",
"2uzy",
"3afc",
"3al8",
"3al9",
"3nvn",
"3nvq",
"3nvx",
"3okt",
"3okw",
"3oky",
"3ol2",
"4fww",
"4gz8",
"4gza",
"4k3j",
"4o3t",
"4o3u",
"4qt8",
"5b4w",
"5l56",
"5l59",
"5l5c",
"5l5g",
"5l5k",
"5l5l",
"5l5m",
"5l5n",
"6fkk"... | 57 | [
"PUB00000965",
"PUB00015414",
"PUB00015415",
"PUB00015416",
"PUB00018450"
] | [
"9875845",
"12925274",
"12958590",
"15167892",
"9712866"
] | [
"Plexin A is a neuronal semaphorin receptor that controls axon guidance.",
"Structure of the semaphorin-3A receptor binding module.",
"The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D.",
"Crystal structure of the HGF beta-chain in complex with the Sema dom... | [
1998,
2003,
2003,
2004,
1998
] | 5 | [] | [
"IPR015513",
"IPR039413",
"IPR041853",
"IPR042068",
"IPR042582",
"IPR042719",
"IPR042744",
"IPR042820",
"IPR042821",
"IPR042824",
"IPR042826",
"IPR047085",
"IPR048224"
] | 0 | 13 | 0 | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
33,
54029,
147,
5
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
11,
239,
26,
158,
99,
112
] | 6 | true | Domain | Sema domain | Sema domain | Semap_dom | 6 |
IPR001628 | 1,628 | Zinc finger, nuclear hormone receptor-type | Znf_hrmn_rcpt | Domain | 93,542 | false | false | This entry represents the two C4-type zinc finger modules involved in DNA-binding. Steroid or nuclear hormone receptors constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions, including control of embryonic development, cell differentiation and homeos... | [
"GO:0003700",
"GO:0008270",
"GO:0043565",
"GO:0006355"
] | [
"DNA-binding transcription factor activity",
"zinc ion binding",
"sequence-specific DNA binding",
"regulation of DNA-templated transcription"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process"
] | 4 | [
"PFAM",
"PRINTS",
"PROSITE",
"PROFILE",
"SMART"
] | [
"PF00105",
"PR00047",
"PS00031",
"PS51030",
"SM00399"
] | [
"zf-C4",
"STROIDFINGER",
"NUCLEAR_REC_DBD_1",
"NUCLEAR_REC_DBD_2",
"ZnF_C4"
] | [
92917,
87479,
82403,
92125,
91503
] | 5 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00031",
"R-BTA-1251985",
"R-BTA-1257604",
"R-BTA-381340",
"R-BTA-383280",
"R-BTA-4090294",
"R-BTA-5362517",
"R-BTA-5689896",
"R-BTA-6811558",
"R-BTA-8866427",
"R-BTA-8866910",
"R-BTA-8931987",
"R-BTA-8939211",
"R-BTA-9009391",
"R-BTA-9018519",
"R-BTA-9029569",
"R-BTA-9623433",
... | [
"PROSITEDOC:PDOC00031",
"REACTOME:R-BTA-1251985",
"REACTOME:R-BTA-1257604",
"REACTOME:R-BTA-381340",
"REACTOME:R-BTA-383280",
"REACTOME:R-BTA-4090294",
"REACTOME:R-BTA-5362517",
"REACTOME:R-BTA-5689896",
"REACTOME:R-BTA-6811558",
"REACTOME:R-BTA-8866427",
"REACTOME:R-BTA-8866910",
"REACTOME:R-... | 237 | [
"1a6y",
"1by4",
"1cit",
"1dsz",
"1ga5",
"1gdc",
"1glu",
"1hcp",
"1hcq",
"1hlz",
"1hra",
"1kb2",
"1kb4",
"1kb6",
"1lat",
"1lo1",
"1r0n",
"1r0o",
"1r4i",
"1r4o",
"1r4r",
"1rgd",
"1rxr",
"1ynw",
"2a66",
"2c7a",
"2ebl",
"2env",
"2ff0",
"2gda",
"2han",
"2nll"... | 116 | [
"PUB00014077",
"PUB00016723",
"PUB00016724",
"PUB00035804",
"PUB00035805",
"PUB00035806",
"PUB00035807",
"PUB00035812"
] | [
"12665246",
"15242341",
"15242339",
"17210253",
"15963892",
"15718139",
"10529348",
"11179890"
] | [
"Zinc fingers--folds for many occasions.",
"Gene repression by nuclear hormone receptors.",
"DNA recognition by nuclear receptors.",
"Sticky fingers: zinc-fingers as protein-recognition motifs.",
"Multiple modes of RNA recognition by zinc finger proteins.",
"Zinc finger proteins: getting a grip on RNA.",
... | [
2002,
2004,
2004,
2007,
2005,
2005,
1999,
2001
] | 8 | [] | [
"IPR042153",
"IPR044101",
"IPR047159",
"IPR048245",
"IPR049636"
] | 0 | 5 | 0 | [
"Avian erythroblastosis virus",
"Eukaryota",
"Pseudomonadati",
"metagenomes"
] | [
4,
93533,
3,
2
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
381,
317,
61,
403,
188,
253
] | 6 | true | Domain | Zinc finger, nuclear hormone receptor-type | Zinc finger, nuclear hormone receptor-type | Znf_hrmn_rcpt | 2 |
IPR001630 | 1,630 | cAMP response element binding (CREB) protein | Leuzip_CREB | Family | 7,098 | false | false | Transcription initiation is dictated by the presence and activity of specific nuclear factors that bind to DNA regulatory sequences and interact with the transcriptional machinery. The functions of some of these factors can be altered by phosphorylation, which affects both DNA binding and transcriptional activation [ ]... | [
"GO:0003677",
"GO:0003700",
"GO:0006355",
"GO:0005634"
] | [
"DNA binding",
"DNA-binding transcription factor activity",
"regulation of DNA-templated transcription",
"nucleus"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"PANTHER"
] | [
"PTHR45879"
] | [
""
] | [
7098
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-199920",
"R-CEL-198693",
"R-CEL-199920",
"R-CEL-375165",
"R-CEL-442742",
"R-CEL-881907",
"R-CEL-9031628",
"R-CEL-9634638",
"R-DME-198693",
"R-DME-199920",
"R-DME-375165",
"R-DME-442742",
"R-DME-881907",
"R-DME-9634638",
"R-HSA-111931",
"R-HSA-111932",
"R-HSA-198693",
"R-HSA-... | [
"REACTOME:R-BTA-199920",
"REACTOME:R-CEL-198693",
"REACTOME:R-CEL-199920",
"REACTOME:R-CEL-375165",
"REACTOME:R-CEL-442742",
"REACTOME:R-CEL-881907",
"REACTOME:R-CEL-9031628",
"REACTOME:R-CEL-9634638",
"REACTOME:R-DME-198693",
"REACTOME:R-DME-199920",
"REACTOME:R-DME-375165",
"REACTOME:R-DME-4... | 55 | [
"1dh3",
"1kdx",
"2lxt",
"5zk1",
"5zko"
] | 5 | [
"PUB00000850",
"PUB00003661",
"PUB00004041"
] | [
"1847666",
"2141384",
"2521922"
] | [
"CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription.",
"Cyclic AMP-dependent protein kinase regulates transcription of the phosphoenolpyruvate carboxykinase gene but not binding of nuclear factors to the cyclic AMP regulatory element.",
"A cluster of p... | [
1991,
1990,
1989
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
7098
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
22,
6,
33,
47,
30
] | 6 | true | Family | cAMP response element binding (CREB) protein | cAMP response element binding (CREB) protein | Leuzip_CREB | 3 |
IPR001632 | 1,632 | G-protein beta subunit-like, WD40 repeats | WD40_G-protein_beta-like | Domain | 15,150 | false | false | This entry represents a region of WD40 repeats found in the G protein beta subunit, Chromatin assembly factor 1 subunit B, Notchless protein homolog and similar proteins mainly found in eukaryotes. G protein beta subunit assumes a barrel-shaped β-propeller structure containing WD-40 repeats preceded by an N-terminal α ... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR00319"
] | [
"GPROTEINB"
] | [
15150
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1296041",
"R-BTA-202040",
"R-BTA-2485179",
"R-BTA-381676",
"R-BTA-381753",
"R-BTA-381771",
"R-BTA-392170",
"R-BTA-392451",
"R-BTA-392851",
"R-BTA-400042",
"R-BTA-4086398",
"R-BTA-416476",
"R-BTA-416482",
"R-BTA-418217",
"R-BTA-418555",
"R-BTA-418592",
"R-BTA-418594",
"R-BTA-... | [
"REACTOME:R-BTA-1296041",
"REACTOME:R-BTA-202040",
"REACTOME:R-BTA-2485179",
"REACTOME:R-BTA-381676",
"REACTOME:R-BTA-381753",
"REACTOME:R-BTA-381771",
"REACTOME:R-BTA-392170",
"REACTOME:R-BTA-392451",
"REACTOME:R-BTA-392851",
"REACTOME:R-BTA-400042",
"REACTOME:R-BTA-4086398",
"REACTOME:R-BTA-... | 196 | [
"1a0r",
"1b9x",
"1b9y",
"1gg2",
"1got",
"1gp2",
"1omw",
"1tbg",
"1xhm",
"2bcj",
"2pbi",
"2trc",
"3ah8",
"3cik",
"3krw",
"3krx",
"3psc",
"3pvu",
"3pvw",
"3sn6",
"3uzs",
"3v5w",
"4kfm",
"4mk0",
"4pnk",
"4v3p",
"4v7e",
"4wjv",
"5he0",
"5he1",
"5he2",
"5he3"... | 1,328 | [
"PUB00005142",
"PUB00015166",
"PUB00015168",
"PUB00015169",
"PUB00015170",
"PUB00015171",
"PUB00015172",
"PUB00098126",
"PUB00161729"
] | [
"1902986",
"15294442",
"15119945",
"14762218",
"11313912",
"9278091",
"11882385",
"9813080",
"23572950"
] | [
"Diversity of G proteins in signal transduction.",
"G protein activation by G protein coupled receptors: ternary complex formation or catalyzed reaction?",
"Biochemistry of transmembrane signaling mediated by trimeric G proteins.",
"G protein signaling: insights from new structures.",
"Regulation of G prote... | [
1991,
2004,
2004,
2004,
2001,
1997,
2002,
1998,
2010
] | 9 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
228,
14917,
5
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
10,
4,
14,
5,
43,
27,
2,
9,
33,
1,
3,
14
] | 12 | true | Domain | G-protein beta subunit-like, WD40 repeats | G-protein beta subunit-like, WD40 repeats | WD40_G-protein_beta-like | 2 |
IPR001633 | 1,633 | EAL domain | EAL_dom | Domain | 196,605 | false | false | This domain is found in diverse bacterial signalling proteins. It is called EAL after its conserved residues. The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP [ , , ], and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL mig... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART",
"CDD"
] | [
"PF00563",
"PS50883",
"SM00052",
"cd01948"
] | [
"EAL",
"EAL",
"EAL",
"EAL"
] | [
192983,
193599,
187754,
181161
] | 4 | [
"PROSITEDOC"
] | [
"PDOC50883"
] | [
"PROSITEDOC:PDOC50883"
] | 1 | [
"2bas",
"2cnr",
"2koo",
"2kop",
"2koq",
"2kor",
"2kos",
"2r6o",
"2w27",
"3gfx",
"3gfy",
"3gfz",
"3gg0",
"3gg1",
"3hv8",
"3hv9",
"3kzp",
"3n3t",
"3pfm",
"3pjt",
"3pju",
"3pjw",
"3pjx",
"3s83",
"3sy8",
"3tlq",
"3u2e",
"4afy",
"4ag0",
"4es4",
"4f3h",
"4f48"... | 82 | [
"PUB00007150",
"PUB00017392",
"PUB00019611",
"PUB00020997"
] | [
"11557134",
"15306016",
"15063857",
"15289546"
] | [
"Novel domains of the prokaryotic two-component signal transduction systems.",
"GGDEF and EAL domains inversely regulate cyclic di-GMP levels and transition from sessility to motility.",
"Cyclic di-guanosine-monophosphate comes of age: a novel secondary messenger involved in modulating cell surface structures i... | [
2001,
2004,
2004,
2004
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"plasmids",
"unclassified sequences"
] | [
22,
193959,
316,
9,
2,
2297
] | 6 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica"
] | [
2,
18,
2
] | 3 | true | Domain | EAL domain | EAL domain | EAL_dom | 6 |
IPR001634 | 1,634 | Adenosine receptor | Adenosn_rcpt | Family | 5,351 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0001609",
"GO:0001973",
"GO:0016020"
] | [
"G protein-coupled adenosine receptor activity",
"G protein-coupled adenosine receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR00424"
] | [
"ADENOSINER"
] | [
5351
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-417973",
"R-BTA-418555",
"R-BTA-418594",
"R-BTA-5683826",
"R-CFA-417973",
"R-CFA-418594",
"R-CFA-5683826",
"R-GGA-417973",
"R-GGA-418555",
"R-GGA-418594",
"R-GGA-5683826",
"R-HSA-187024",
"R-HSA-417973",
"R-HSA-418555",
"R-HSA-418594",
"R-HSA-5683826",
"R-HSA-9660821",
"R-MM... | [
"REACTOME:R-BTA-417973",
"REACTOME:R-BTA-418555",
"REACTOME:R-BTA-418594",
"REACTOME:R-BTA-5683826",
"REACTOME:R-CFA-417973",
"REACTOME:R-CFA-418594",
"REACTOME:R-CFA-5683826",
"REACTOME:R-GGA-417973",
"REACTOME:R-GGA-418555",
"REACTOME:R-GGA-418594",
"REACTOME:R-GGA-5683826",
"REACTOME:R-HSA-... | 24 | [
"2ydo",
"2ydv",
"3pwh",
"3rey",
"3rfm",
"3uza",
"3uzc",
"3vg9",
"3vga",
"4eiy",
"4ug2",
"4uhr",
"5g53",
"5iu4",
"5iu7",
"5iu8",
"5iua",
"5iub",
"5jtb",
"5k2a",
"5k2b",
"5k2c",
"5k2d",
"5mzj",
"5mzp",
"5n2r",
"5n2s",
"5nlx",
"5nm2",
"5nm4",
"5olg",
"5olh"... | 103 | [
"PUB00000131",
"PUB00002477",
"PUB00004960",
"PUB00004961",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816"
] | [
"2111655",
"2830256",
"8386361",
"8170923",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293"
] | [
"G proteins in signal transduction.",
"G protein involvement in receptor-effector coupling.",
"Design of a discriminating fingerprint for G-protein-coupled receptors.",
"Fingerprinting G-protein-coupled receptors.",
"The G protein-coupled receptor repertoires of human and mouse.",
"GCRDb: a G-protein-coup... | [
1990,
1988,
1993,
1994,
2003,
1994,
2005,
2009,
2006,
2013
] | 10 | [
"IPR000276"
] | [
"IPR000466",
"IPR001068",
"IPR001435",
"IPR001513"
] | 1 | 4 | 0 | [
"Bilateria"
] | [
5351
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
12,
17,
16,
17
] | 4 | true | Family | Adenosine receptor | Adenosine receptor | Adenosn_rcpt | 5 |
IPR001635 | 1,635 | Flagellar hook-length control protein FliK | Flag_hook_Flik | Family | 3,310 | false | false | FliK controls the length of the flagellar hook. It detects when the flagellar hook substructure has reached its optimal length. Then, it terminates hook export and assembly and transmits a signal to begin filament export, the final stage in flagellar biosynthesis. The exact mechanism of how FliK achieves this is not kn... | [
"GO:0044780",
"GO:0009424"
] | [
"bacterial-type flagellum assembly",
"bacterial-type flagellum hook"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01007"
] | [
"FLGHOOKFLIK"
] | [
3310
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00002296",
"PUB00067596",
"PUB00067597"
] | [
"8631687",
"17456739",
"22797757"
] | [
"Characterization of the flagellar hook length control protein fliK of Salmonella typhimurium and Escherichia coli.",
"The FliK protein and flagellar hook-length control.",
"Mystery of fliK in length control of the flagellar hook."
] | [
1996,
2007,
2012
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
3271,
14,
25
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Flagellar hook-length control protein FliK | Flagellar hook-length control protein FliK | Flag_hook_Flik | 8 |
IPR001636 | 1,636 | Phosphoribosylaminoimidazole-succinocarboxamide synthase | SAICAR_synth | Family | 21,511 | false | false | Phosphoribosylaminoimidazole-succinocarboxamide synthase ( ) (SAICAR synthetase) catalyses the seventh step in the de novo purine biosynthetic pathway; the ATP-dependent conversion of 5'-phosphoribosyl-5-aminoimidazole-4-carboxylic acid and aspartic acid to SAICAR [ , ]. In bacteria (purC), fungi (ADE1) and plants (Pur... | [
"GO:0004639",
"GO:0006164"
] | [
"phosphoribosylaminoimidazolesuccinocarboxamide synthase activity",
"purine nucleotide biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00081"
] | [
"purC"
] | [
21511
] | 1 | [
"EC",
"GP",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"PROSITEDOC"
] | [
"6.3.2.6",
"GenProp0110",
"GenProp1730",
"GenProp1757",
"PWY-6123",
"PWY-6124",
"PWY-7234",
"PDOC00810"
] | [
"EC:6.3.2.6",
"GP:GenProp0110",
"GP:GenProp1730",
"GP:GenProp1757",
"METACYC:PWY-6123",
"METACYC:PWY-6124",
"METACYC:PWY-7234",
"PROSITEDOC:PDOC00810"
] | 8 | [
"1a48",
"1obd",
"1obg",
"2cnq",
"2cnu",
"2cnv",
"2gqr",
"2gqs",
"2ywv",
"2yzl",
"2z02",
"3kre",
"3nua",
"3r9r",
"3u54",
"3u55",
"4fe2",
"4fgr",
"4nye",
"4o7l",
"4o7n",
"4o7r",
"4o7s",
"4o7t",
"4o7v",
"4o7w",
"4o7y",
"4o7z",
"4o81",
"4o82",
"4o83",
"4o84"... | 45 | [
"PUB00004940",
"PUB00070198"
] | [
"1574589",
"15641804"
] | [
"De novo purine nucleotide biosynthesis.",
"Mechanism of action of Escherichia coli phosphoribosylaminoimidazolesuccinocarboxamide synthetase."
] | [
1992,
2005
] | 2 | [] | [
"IPR033934"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Kyanoviridae",
"unclassified sequences"
] | [
387,
19066,
1673,
22,
363
] | 5 | [
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1,
1
] | 4 | true | Family | Phosphoribosylaminoimidazole-succinocarboxamide synthase | Phosphoribosylaminoimidazole-succinocarboxamide synthase | SAICAR_synth | 1 |
IPR001637 | 1,637 | Glutamine synthetase class-I, adenylation site | Gln_synth_I_adenylation_site | Conserved_site | 11,813 | false | false | Glutamine synthetase ( ) (GS) [ ] plays an essential role in the metabolism of nitrogen by catalyzing the condensation of glutamate and ammonia to form glutamine. There seem to be three different classes of GS [ , , ]: Class I enzymes (GSI) are specific to prokaryotes, and are oligomers of 12 identical subunits. The ac... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS00182"
] | [
"GLNA_ADENYLATION"
] | [
11813
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"PROSITEDOC"
] | [
"6.3.1.2",
"PWY-6963",
"PWY-6964",
"PWY-8291",
"PWY-8294",
"PDOC00162"
] | [
"EC:6.3.1.2",
"METACYC:PWY-6963",
"METACYC:PWY-6964",
"METACYC:PWY-8291",
"METACYC:PWY-8294",
"PROSITEDOC:PDOC00162"
] | 6 | [
"1f1h",
"1f52",
"1fpy",
"1hto",
"1htq",
"1lgr",
"2bvc",
"2gls",
"2lgs",
"2wgs",
"2whi",
"3zxr",
"3zxv",
"4acf",
"4lnf",
"4lni",
"4lnk",
"4lnn",
"4lno",
"4s0r",
"4xyc",
"5ldf",
"7tfc",
"7w85",
"8fbp",
"8v1y",
"8v22",
"9k2n",
"9n4x"
] | 29 | [
"PUB00000993",
"PUB00003408",
"PUB00003430",
"PUB00004813"
] | [
"2900091",
"2575672",
"7916055",
"8096645"
] | [
"Some evolutionary relationships of the primary biological catalysts glutamine synthetase and RuBisCO.",
"Glutamine synthetase II in Rhizobium: reexamination of the proposed horizontal transfer of DNA from eukaryotes to prokaryotes.",
"Evolutionary relationships of bacterial and archaeal glutamine synthetase ge... | [
1987,
1989,
1994,
1993
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
10,
11581,
31,
191
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Conserved_site | Glutamine synthetase class-I, adenylation site | Glutamine synthetase class-I, adenylation site | Gln_synth_I_adenylation_site | 9 |
IPR001638 | 1,638 | Solute-binding protein family 3/N-terminal domain of MltF | Solute-binding_3/MltF_N | Domain | 205,238 | false | false | Bacterial high affinity transport systems are involved in active transport of solutes across the cytoplasmic membrane. Most of the bacterial ABC (ATP-binding cassette) importers are composed of one or two transmembrane permease proteins, one or two nucleotide-binding proteins and a highly specific periplasmic solute-bi... | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF00497",
"SM00062"
] | [
"SBP_bac_3",
"PBPb"
] | [
175000,
192754
] | 2 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC00798",
"R-CEL-204005",
"R-CEL-399710",
"R-CEL-438066",
"R-CEL-5694530",
"R-CEL-8849932"
] | [
"PROSITEDOC:PDOC00798",
"REACTOME:R-CEL-204005",
"REACTOME:R-CEL-399710",
"REACTOME:R-CEL-438066",
"REACTOME:R-CEL-5694530",
"REACTOME:R-CEL-8849932"
] | 6 | [
"1ftj",
"1ftk",
"1ftl",
"1ftm",
"1fto",
"1fw0",
"1ggg",
"1gr2",
"1hpb",
"1hsl",
"1ii5",
"1iit",
"1iiw",
"1laf",
"1lag",
"1lah",
"1lb8",
"1lb9",
"1lbb",
"1lbc",
"1lst",
"1m5b",
"1m5c",
"1m5d",
"1m5e",
"1m5f",
"1mm6",
"1mm7",
"1mqd",
"1mqg",
"1mqh",
"1mqi"... | 583 | [
"PUB00003610",
"PUB00054945",
"PUB00071925",
"PUB00071938"
] | [
"8336670",
"18234673",
"18310026",
"8003968"
] | [
"Structural, functional, and evolutionary relationships among extracellular solute-binding receptors of bacteria.",
"The C-terminal domain of Escherichia coli YfhD functions as a lytic transglycosylase.",
"Characterization of a Pseudomonas putida ABC transporter (AatJMQP) required for acidic amino acid uptake: ... | [
1993,
2008,
2008,
1994
] | 4 | [] | [
"IPR037297",
"IPR037298"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
926,
200544,
2518,
10,
1240
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
4,
3,
1,
2,
12,
5,
1
] | 7 | true | Domain | Solute-binding protein family 3/N-terminal domain of MltF | Solute-binding protein family 3/N-terminal domain of MltF | Solute-binding_3/MltF_N | 3 |
IPR001639 | 1,639 | Type II secretion system protein GspC | T2SS_protein-GspC | Family | 1,678 | false | false | GspC is part of the type 2 secretion systems (T2SSs). GspC interacts with GspD. It is an inner membrane protein consisting of a short N-terminal cytoplasmic sequence and an α-helical transmembrane segment, followed by two periplasmic domains: a so-called homology region (HR) and a C-terminal PDZ domain [ ]. The type II... | [
"GO:0015628",
"GO:0015627"
] | [
"protein secretion by the type II secretion system",
"type II protein secretion system complex"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PRINTS",
"PROSITE",
"NCBIFAM"
] | [
"PR00810",
"PS01141",
"TIGR01713"
] | [
"BCTERIALGSPC",
"T2SP_C",
"typeII_sec_gspC"
] | [
155,
625,
1664
] | 3 | [
"GP",
"PROSITEDOC",
"REACTOME"
] | [
"GenProp0053",
"PDOC00878",
"R-HSA-9760173"
] | [
"GP:GenProp0053",
"PROSITEDOC:PDOC00878",
"REACTOME:R-HSA-9760173"
] | 3 | [
"2i4s",
"2i6v",
"2lnv",
"5hj1",
"6hcg"
] | 5 | [
"PUB00051842",
"PUB00093998",
"PUB00094002",
"PUB00094004"
] | [
"19217396",
"30767847",
"28258547",
"22523076"
] | [
"Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody.",
"Architecture, Function, and Substrates of the Type II Secretion System.",
"1H, 15N and 13C resonance assignments and secondary structure of PulG, the major pseudopilin from Klebsiella oxyt... | [
2009,
2019,
2017,
2012
] | 4 | [] | [] | 0 | 0 | null | [
"Acyrthosiphon pisum",
"Bacteria",
"metagenomes"
] | [
1,
1651,
26
] | 3 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Type II secretion system protein GspC | Type II secretion system protein GspC | T2SS_protein-GspC | 6 |
IPR001641 | 1,641 | Spumavirus aspartic protease A9 | Spumavirus_A9 | Domain | 477 | false | false | Foamy viruses (FV) or spumavirus are single-stranded enveloped retroviruses that have been noted to infect monkeys, cats and humans. At present, the virus has not been proven to cause any particular disease. However, studies have shown Human foamy virus causes neurological disorders in infected mice [ ]. The virus geno... | [
"GO:0004190",
"GO:0006508"
] | [
"aspartic-type endopeptidase activity",
"proteolysis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PRINTS",
"PROFILE"
] | [
"PF03539",
"PR00920",
"PS51531"
] | [
"Spuma_A9PTase",
"SPUMVIRPTASE",
"FV_PR"
] | [
461,
174,
187
] | 3 | [
"EC",
"EC",
"EC",
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.7.7.-",
"2.7.7.49",
"2.7.7.7",
"3.1.26.4",
"3.4.23.-",
"PWY-6322",
"PWY-6626",
"PWY-6749",
"PWY-6955",
"PWY-6998",
"PWY-7127",
"PWY-7419",
"PWY-7529",
"PWY-7706",
"PWY-7719",
"PWY-7735",
"PWY-7737",
"PWY-7769",
"PWY-7888",
"PWY-7904",
"PWY-8117",
"PWY-8179"
] | [
"EC:2.7.7.-",
"EC:2.7.7.49",
"EC:2.7.7.7",
"EC:3.1.26.4",
"EC:3.4.23.-",
"METACYC:PWY-6322",
"METACYC:PWY-6626",
"METACYC:PWY-6749",
"METACYC:PWY-6955",
"METACYC:PWY-6998",
"METACYC:PWY-7127",
"METACYC:PWY-7419",
"METACYC:PWY-7529",
"METACYC:PWY-7706",
"METACYC:PWY-7719",
"METACYC:PWY-... | 22 | [
"2jys",
"7kse",
"7ksf",
"7o0g",
"7o0h",
"7o24"
] | 6 | [
"PUB00000093",
"PUB00000349",
"PUB00000522",
"PUB00001330",
"PUB00001804",
"PUB00003482",
"PUB00004317",
"PUB00011023",
"PUB00011707",
"PUB00021296",
"PUB00042504",
"PUB00048142",
"PUB00065205",
"PUB00066803",
"PUB00076784",
"PUB00076785",
"PUB00076786",
"PUB00076800",
"PUB000768... | [
"2194475",
"1851433",
"8439290",
"6795036",
"1647358",
"2451755",
"9549727",
"10331925",
"11566868",
"10864493",
"2682266",
"18597783",
"23254940",
"21765428",
"4912600",
"10497172",
"21751400",
"10438890",
"9696869"
] | [
"The structure and function of the aspartic proteinases.",
"Structural and evolutionary relationships between retroviral and eucaryotic aspartic proteinases.",
"Evolutionary families of peptidases.",
"Gastric proteinases--structure, function, evolution and mechanism of action.",
"Sequence analysis of the si... | [
1990,
1991,
1993,
1981,
1991,
1988,
1998,
1999,
2001,
2000,
1989,
2008,
2013,
2011,
1970,
1999,
2011,
1999,
1998
] | 19 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"marine sediment metagenome"
] | [
8,
293,
175,
1
] | 4 | [] | [] | 0 | true | Domain | Spumavirus aspartic protease A9 | Spumavirus aspartic protease A9 | Spumavirus_A9 | 3 |
IPR001642 | 1,642 | Neuromedin B receptor | NeuroB_rcpt | Family | 651 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0004946",
"GO:0031989",
"GO:0016020"
] | [
"bombesin receptor activity",
"bombesin receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR00639"
] | [
"NEUROMEDINBR"
] | [
651
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-375276",
"R-HSA-416476",
"R-MMU-375276",
"R-MMU-416476",
"R-RNO-375276",
"R-RNO-416476",
"R-SSC-375276",
"R-SSC-416476"
] | [
"REACTOME:R-HSA-375276",
"REACTOME:R-HSA-416476",
"REACTOME:R-MMU-375276",
"REACTOME:R-MMU-416476",
"REACTOME:R-RNO-375276",
"REACTOME:R-RNO-416476",
"REACTOME:R-SSC-375276",
"REACTOME:R-SSC-416476"
] | 8 | [
"8h0p",
"9jf4"
] | 2 | [
"PUB00000131",
"PUB00002477",
"PUB00004960",
"PUB00004961",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816"
] | [
"2111655",
"2830256",
"8386361",
"8170923",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293"
] | [
"G proteins in signal transduction.",
"G protein involvement in receptor-effector coupling.",
"Design of a discriminating fingerprint for G-protein-coupled receptors.",
"Fingerprinting G-protein-coupled receptors.",
"The G protein-coupled receptor repertoires of human and mouse.",
"GCRDb: a G-protein-coup... | [
1990,
1988,
1993,
1994,
2003,
1994,
2005,
2009,
2006,
2013
] | 10 | [
"IPR001556"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
651
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
4,
3
] | 3 | true | Family | Neuromedin B receptor | Neuromedin B receptor | NeuroB_rcpt | 7 |
IPR001644 | 1,644 | C3a anaphylatoxin chemotactic receptor | Anaphtx_C3AR1 | Family | 262 | false | false | The activation of the complement cascade produces a number of small fragments that are bioactive: potent chemoattractants and secretagogues that act on immune and non-immune cells [ ]. Similar peptides can also be released by the actions of non-complement proteases, for instance during clotting [ ]. Initially these wer... | [
"GO:0004876",
"GO:0006935",
"GO:0007186",
"GO:0016020"
] | [
"complement component C3a receptor activity",
"chemotaxis",
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PRINTS"
] | [
"PR01060"
] | [
"C3ANPHYLTXNR"
] | [
262
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-375276",
"R-HSA-418594",
"R-HSA-6798695",
"R-HSA-9660826",
"R-HSA-977606",
"R-MMU-375276",
"R-MMU-418594",
"R-MMU-6798695",
"R-MMU-977606",
"R-RNO-375276",
"R-RNO-418594",
"R-RNO-6798695",
"R-RNO-977606"
] | [
"REACTOME:R-HSA-375276",
"REACTOME:R-HSA-418594",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-9660826",
"REACTOME:R-HSA-977606",
"REACTOME:R-MMU-375276",
"REACTOME:R-MMU-418594",
"REACTOME:R-MMU-6798695",
"REACTOME:R-MMU-977606",
"REACTOME:R-RNO-375276",
"REACTOME:R-RNO-418594",
"REACTOME:R-RNO-... | 13 | [
"8hk2",
"8hk3",
"8i95",
"8i97",
"8i9a",
"8i9l",
"8i9s",
"8ia8",
"8j6d",
"8zwf",
"8zwg",
"9ipv",
"9ipy",
"9isi"
] | 14 | [
"PUB00001480",
"PUB00002962",
"PUB00066912",
"PUB00066913",
"PUB00066914",
"PUB00066915",
"PUB00066916",
"PUB00066917",
"PUB00066919",
"PUB00066920",
"PUB00066921",
"PUB00066922",
"PUB00066923",
"PUB00066924",
"PUB00066925",
"PUB00066926",
"PUB00066928",
"PUB00066929",
"PUB000669... | [
"8765043",
"8702752",
"17603557",
"19025115",
"19601884",
"22118769",
"19477527",
"9725198",
"2528484",
"11165367",
"8011297",
"8605247",
"1847994",
"12429062",
"15833747",
"17322907",
"11342658",
"16154494",
"14570896",
"9108406",
"22500977",
"8156000",
"19265162",
"21... | [
"Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells.",
"Molecular cloning and characterization of the human anaphylatoxin C3a receptor.",
"Function, structure and therapeutic potential of complement C5a receptors.",
"Interaction between the coagulation and comple... | [
1996,
1996,
2007,
2008,
2009,
2011,
2009,
1998,
1989,
2001,
1994,
1996,
1991,
2002,
2005,
2007,
2001,
2005,
2004,
1997,
2012,
1994,
2009,
2011,
2012,
2012
] | 26 | [
"IPR002234"
] | [] | 1 | 0 | 1 | [
"Opisthokonta"
] | [
262
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
4,
3
] | 3 | true | Family | C3a anaphylatoxin chemotactic receptor | C3a anaphylatoxin chemotactic receptor | Anaphtx_C3AR1 | 2 |
IPR001645 | 1,645 | Folylpolyglutamate synthetase | Folylpolyglutamate_synth | Family | 39,408 | false | false | Folylpolyglutamate synthase (FPGS) is an ATP-dependent enzyme that is responsible for the addition of a polyglutamate tail to folate and folate derivatives [ ]. It plays a key role in the retention of the intracellular folate pool. In some bacteria, such as Escherichia coli, the addition of L-glutamate to dihydropteroa... | [
"GO:0004326",
"GO:0005524",
"GO:0009396"
] | [
"tetrahydrofolylpolyglutamate synthase activity",
"ATP binding",
"folic acid-containing compound biosynthetic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PIRSF",
"PANTHER",
"NCBIFAM"
] | [
"PIRSF001563",
"PTHR11136",
"TIGR01499"
] | [
"Folylpolyglu_synth",
"",
"folC"
] | [
24647,
38902,
37728
] | 3 | [
"EC",
"GP",
"GP",
"METACYC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"6.3.2.17",
"GenProp0038",
"GenProp1616",
"PWY-2161",
"PDOC00773",
"R-CEL-196757",
"R-DDI-196757",
"R-HSA-196757",
"R-MMU-196757",
"R-SCE-196757",
"R-SPO-196757"
] | [
"EC:6.3.2.17",
"GP:GenProp0038",
"GP:GenProp1616",
"METACYC:PWY-2161",
"PROSITEDOC:PDOC00773",
"REACTOME:R-CEL-196757",
"REACTOME:R-DDI-196757",
"REACTOME:R-HSA-196757",
"REACTOME:R-MMU-196757",
"REACTOME:R-SCE-196757",
"REACTOME:R-SPO-196757"
] | 11 | [
"1fgs",
"1jbv",
"1jbw",
"1o5z",
"1w78",
"1w7k",
"2gc5",
"2gc6",
"2gca",
"2gcb",
"2vor",
"2vos",
"3n2a",
"3nrs",
"3pyz",
"3qcz",
"6k8c"
] | 17 | [
"PUB00006413",
"PUB00032198"
] | [
"9618466",
"15705579"
] | [
"Structural homologies with ATP- and folate-binding enzymes in the crystal structure of folylpolyglutamate synthetase.",
"Escherichia coli FolC structure reveals an unexpected dihydrofolate binding site providing an attractive target for anti-microbial therapy."
] | [
1998,
2005
] | 2 | [] | [
"IPR023600"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
461,
27550,
10708,
1,
688
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
23,
1,
1,
4,
1,
6,
3,
3,
14,
7,
3,
2,
58
] | 13 | true | Family | Folylpolyglutamate synthetase | Folylpolyglutamate synthetase | Folylpolyglutamate_synth | 2 |
IPR001646 | 1,646 | Pentapeptide repeat | 5peptide_repeat | Repeat | 60,704 | false | false | These repeats were first identified in many cyanobacterial proteins but they are now found ubiquitously in all kingdoms of life [ ]. The repeats were first identified in hglK [ ]. Pentapeptide repeat proteins (PRPs) are characterised by the repetition of the pentapeptide repeat motif [S,T,A,V][D,N][L,F][S,T,R][G], whic... | [] | [] | [] | 0 | [
"PFAM",
"PFAM",
"PFAM"
] | [
"PF00805",
"PF13576",
"PF13599"
] | [
"Pentapeptide",
"Pentapeptide_3",
"Pentapeptide_4"
] | [
51557,
4064,
13283
] | 3 | [] | [] | [] | 0 | [
"2bm4",
"2bm5",
"2bm6",
"2bm7",
"2f3l",
"2g0y",
"2j8i",
"2j8k",
"2o6w",
"2w7z",
"2xt2",
"2xt4",
"2xtw",
"2xtx",
"2xty",
"3du1",
"3n90",
"3naw",
"3nb2",
"3pss",
"3psz",
"3sqv",
"4yc5",
"4ycq",
"4ydt",
"4yei",
"4yfo",
"5di5",
"5dn0",
"5dns",
"5dqa",
"5dra"... | 41 | [
"PUB00001717",
"PUB00002283",
"PUB00005053",
"PUB00039677",
"PUB00094375",
"PUB00160275",
"PUB00160276"
] | [
"9654141",
"7592418",
"9655353",
"15933203",
"19060136",
"17075135",
"32092202"
] | [
"Characterisation of an Arabidopsis cDNA encoding a thylakoid lumen protein related to a novel 'pentapeptide repeat' family of proteins.",
"The hglK gene is required for localization of heterocyst-specific glycolipids in the cyanobacterium Anabaena sp. strain PCC 7120.",
"Structure and distribution of pentapept... | [
1998,
1995,
1998,
2005,
2009,
2006,
2020
] | 7 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
873,
48602,
9977,
251,
1001
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
24,
4,
2,
2,
2,
5,
13,
4,
17
] | 9 | true | Repeat | Pentapeptide repeat | Pentapeptide repeat | 5peptide_repeat | 6 |
IPR001647 | 1,647 | DNA-binding HTH domain, TetR-type | HTH_TetR | Domain | 655,396 | false | false | This entry represents a DNA-binding domain with a helix-turn-helix (HTH) structure that is found in several bacterial and archaeal transcriptional regulators, such as TetR, the tetracycline resistance repressor. Numerous other transcriptional regulatory proteins also contain HTH-type DNA-binding domains, and can be gro... | [
"GO:0003677"
] | [
"DNA binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PRINTS",
"PROFILE"
] | [
"PF00440",
"PR00455",
"PS50977"
] | [
"TetR_N",
"HTHTETR",
"HTH_TETR_2"
] | [
634293,
430231,
644623
] | 3 | [
"PROSITEDOC"
] | [
"PDOC00830"
] | [
"PROSITEDOC:PDOC00830"
] | 1 | [
"1a6i",
"1bjz",
"1jt0",
"1jt6",
"1jtx",
"1jty",
"1jum",
"1jup",
"1jus",
"1ork",
"1qpi",
"1qvt",
"1qvu",
"1rkt",
"1rkw",
"1rpw",
"1sgm",
"1t33",
"1t56",
"1u9n",
"1u9o",
"1ui5",
"1ui6",
"1vi0",
"1z0x",
"1z77",
"1zk8",
"1zkg",
"2d6y",
"2dg7",
"2dg8",
"2dtz"... | 560 | [
"PUB00000126",
"PUB00002819",
"PUB00003347",
"PUB00003860"
] | [
"7826010",
"8428974",
"7707374",
"8196548"
] | [
"Mechanisms underlying expression of Tn10 encoded tetracycline resistance.",
"Inhibition by barbiturates of the binding of Bm3R1 repressor to its operator site on the barbiturate-inducible cytochrome P450BM-3 gene of Bacillus megaterium.",
"The complex formed between Tet repressor and tetracycline-Mg2+ reveals ... | [
1994,
1993,
1995,
1994
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"plasmids",
"unclassified sequences"
] | [
2271,
649215,
287,
18,
4,
3601
] | 6 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)"
] | [
1,
13
] | 2 | true | Domain | DNA-binding HTH domain, TetR-type | DNA-binding HTH domain, TetR-type | HTH_TetR | 5 |
IPR001648 | 1,648 | Small ribosomal subunit protein bS18 | Ribosomal_bS18 | Family | 45,842 | false | false | This entry represents the small ribosomal subunit protein bS18. Evidence suggests that, in prokaryotes, the peptidyl transferase reaction is performed by the large subunit 23S rRNA, whereas proteins probably have a greater role in eukaryotic ribosomes. Most of the proteins lie close to, or on the surface of, the 30S su... | [
"GO:0003735",
"GO:0006412",
"GO:0005840"
] | [
"structural constituent of ribosome",
"translation",
"ribosome"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"HAMAP",
"PFAM",
"PRINTS",
"PANTHER",
"NCBIFAM"
] | [
"MF_00270",
"PF01084",
"PR00974",
"PTHR13479",
"TIGR00165"
] | [
"Ribosomal_bS18",
"Ribosomal_S18",
"RIBOSOMALS18",
"",
"S18"
] | [
38463,
45800,
40506,
43846,
40534
] | 5 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC00056",
"R-BTA-5389840",
"R-BTA-5419276",
"R-BTA-9937383",
"R-HSA-5368286",
"R-HSA-5389840",
"R-HSA-5419276",
"R-HSA-9937383",
"R-MMU-5389840",
"R-MMU-5419276",
"R-MMU-9937383",
"R-SSC-5389840",
"R-SSC-5419276",
"R-SSC-9937383"
] | [
"PROSITEDOC:PDOC00056",
"REACTOME:R-BTA-5389840",
"REACTOME:R-BTA-5419276",
"REACTOME:R-BTA-9937383",
"REACTOME:R-HSA-5368286",
"REACTOME:R-HSA-5389840",
"REACTOME:R-HSA-5419276",
"REACTOME:R-HSA-9937383",
"REACTOME:R-MMU-5389840",
"REACTOME:R-MMU-5419276",
"REACTOME:R-MMU-9937383",
"REACTOME:... | 14 | [
"1fjg",
"1fka",
"1g1x",
"1hnw",
"1hnx",
"1hnz",
"1hr0",
"1i94",
"1i95",
"1i96",
"1i97",
"1ibk",
"1ibl",
"1ibm",
"1j5e",
"1jgo",
"1jgp",
"1jgq",
"1ml5",
"1n32",
"1n33",
"1n34",
"1n36",
"1vvj",
"1vy4",
"1vy5",
"1vy6",
"1vy7",
"1x18",
"1xmo",
"1xmq",
"1xnq"... | 1,326 | [
"PUB00001566",
"PUB00003381",
"PUB00004907",
"PUB00005065",
"PUB00007068",
"PUB00007069",
"PUB00007070",
"PUB00151135"
] | [
"2647521",
"9281425",
"9371771",
"2179947",
"11297922",
"11290319",
"11114498",
"27023846"
] | [
"The complete amino acid sequence of ribosomal protein S18 from the moderate thermophile Bacillus stearothermophilus.",
"A new model for the three-dimensional folding of Escherichia coli 16 S ribosomal RNA. II. The RNA-protein interaction data.",
"Proteins on ribosome surface: measurements of protein exposure b... | [
1989,
1997,
1997,
1990,
2001,
2001,
2000,
2016
] | 8 | [] | [
"IPR040054"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
24349,
21073,
420
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
7,
2,
3,
4,
2,
8,
9,
1,
6,
15,
1,
1,
12
] | 13 | true | Family | Small ribosomal subunit protein bS18 | Small ribosomal subunit protein bS18 | Ribosomal_bS18 | 6 |
IPR001650 | 1,650 | Helicase, C-terminal domain-like | Helicase_C-like | Domain | 916,608 | false | false | Helicases have been classified in 5 superfamilies (SF1-SF5). For the two largest groups, commonly referred to as SF1 and SF2, a total of seven characteristic motifs has been identified [ ]. These two superfamilies encompass a large number of DNA and RNA helicases from archaea, eubacteria, eukaryotes and viruses. This e... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF00271",
"PS51194",
"SM00490"
] | [
"Helicase_C",
"HELICASE_CTER",
"HELICc"
] | [
827891,
887857,
844712
] | 3 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.6.4",
"PDOC51192",
"R-BTA-113418",
"R-BTA-1169408",
"R-BTA-1266695",
"R-BTA-141444",
"R-BTA-156827",
"R-BTA-159236",
"R-BTA-1810476",
"R-BTA-201722",
"R-BTA-2467813",
"R-BTA-2500257",
"R-BTA-3134963",
"R-BTA-3214858",
"R-BTA-3247509",
"R-BTA-429947",
"R-BTA-5663220",
"R-BTA-5696... | [
"EC:3.6.4",
"PROSITEDOC:PDOC51192",
"REACTOME:R-BTA-113418",
"REACTOME:R-BTA-1169408",
"REACTOME:R-BTA-1266695",
"REACTOME:R-BTA-141444",
"REACTOME:R-BTA-156827",
"REACTOME:R-BTA-159236",
"REACTOME:R-BTA-1810476",
"REACTOME:R-BTA-201722",
"REACTOME:R-BTA-2467813",
"REACTOME:R-BTA-2500257",
"... | 573 | [
"1a1v",
"1c4o",
"1cu1",
"1d2m",
"1d9x",
"1d9z",
"1fuk",
"1fuu",
"1gm5",
"1hei",
"1hv8",
"1jr6",
"1m6n",
"1m74",
"1nkt",
"1nl3",
"1onb",
"1oyw",
"1oyy",
"1s2m",
"1t5i",
"1t5l",
"1tf2",
"1tf5",
"1wp9",
"1xti",
"1xtj",
"1xtk",
"1yks",
"1z3i",
"1z5z",
"1z63"... | 1,259 | [
"PUB00004361",
"PUB00025034"
] | [
"2546125",
"11087862"
] | [
"Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes.",
"Crystal structure of yeast initiation factor 4A, a DEAD-box RNA helicase."
] | [
1989,
2000
] | 2 | [] | [
"IPR049730"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
9856,
396680,
456767,
45799,
7506
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
774,
101,
452,
245,
19,
554,
315,
79,
385,
443,
78,
68,
1560
] | 13 | true | Domain | Helicase, C-terminal domain-like | Helicase, C-terminal domain-like | Helicase_C-like | 6 |
IPR001651 | 1,651 | Gastrin/cholecystokinin peptide hormone | Gastrin/CCK | Domain | 1,717 | false | false | Gastrin and cholecystokinin (CCK) are structurally and functionally related peptide hormones that function as hormonal regulators of various digestive processes and feeding behaviors. They are known to induce gastric secretion, stimulate pancreatic secretion, increase blood circulation and water secretion in the stomac... | [
"GO:0005179",
"GO:0005576"
] | [
"hormone activity",
"extracellular region"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF00918"
] | [
"Gastrin"
] | [
1717
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-375276",
"R-BTA-416476",
"R-BTA-881907",
"R-CFA-416476",
"R-CFA-881907",
"R-HSA-375276",
"R-HSA-416476",
"R-HSA-881907",
"R-MMU-375276",
"R-MMU-416476",
"R-MMU-881907",
"R-RNO-375276",
"R-RNO-416476",
"R-RNO-881907",
"R-SSC-375276",
"R-SSC-416476"
] | [
"REACTOME:R-BTA-375276",
"REACTOME:R-BTA-416476",
"REACTOME:R-BTA-881907",
"REACTOME:R-CFA-416476",
"REACTOME:R-CFA-881907",
"REACTOME:R-HSA-375276",
"REACTOME:R-HSA-416476",
"REACTOME:R-HSA-881907",
"REACTOME:R-MMU-375276",
"REACTOME:R-MMU-416476",
"REACTOME:R-MMU-881907",
"REACTOME:R-RNO-375... | 16 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Chordata"
] | [
3,
1714
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
5,
6,
8
] | 4 | true | Domain | Gastrin/cholecystokinin peptide hormone | Gastrin/cholecystokinin peptide hormone | Gastrin/CCK | 2 |
IPR001653 | 1,653 | Diaminopimelate epimerase, DapF | DAP_epimerase_DapF | Family | 26,012 | false | false | This entry represents diaminopimelate epimerase ( ), which catalyses the isomerisation of L,L-dimaminopimelate to meso-DAP in the biosynthetic pathway leading from aspartate to lysine. It is a member of the broader family of PLP-independent amino acid racemases. This enzyme is a monomeric protein of about 30kDa consist... | [
"GO:0008837",
"GO:0009089"
] | [
"diaminopimelate epimerase activity",
"L-lysine biosynthetic process via diaminopimelate"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"PFAM",
"PANTHER",
"NCBIFAM"
] | [
"MF_00197",
"PF01678",
"PTHR31689",
"TIGR00652"
] | [
"DAP_epimerase",
"DAP_epimerase",
"",
"DapF"
] | [
24633,
25899,
25863,
25070
] | 4 | [
"EC",
"GP",
"METACYC",
"METACYC",
"PROSITEDOC"
] | [
"5.1.1.7",
"GenProp0125",
"PWY-2941",
"PWY-5097",
"PDOC01029"
] | [
"EC:5.1.1.7",
"GP:GenProp0125",
"METACYC:PWY-2941",
"METACYC:PWY-5097",
"PROSITEDOC:PDOC01029"
] | 5 | [
"1bwz",
"1gqz",
"2gke",
"2gkj",
"2otn",
"2q9h",
"2q9j",
"3ejx",
"3ekm",
"3fve",
"4ijz",
"4ik0",
"5h2g",
"5h2y",
"5ha4",
"5m47",
"5ygu",
"6d13",
"6d1q",
"6d1v",
"6vck",
"6vcl",
"6vcm",
"7vdy",
"8qzy",
"9mro",
"9mrp",
"9mrv"
] | 28 | [
"PUB00000449",
"PUB00025347",
"PUB00034672",
"PUB00055043"
] | [
"9843410",
"14747737",
"11352712",
"20418392"
] | [
"Structural symmetry: the three-dimensional structure of Haemophilus influenzae diaminopimelate epimerase.",
"Refinement of Haemophilus influenzae diaminopimelic acid epimerase (DapF) at 1.75 A resolution suggests a mechanism for stereocontrol during catalysis.",
"The central enzymes of the aspartate family of ... | [
1998,
2004,
2001,
2010
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
432,
23799,
1163,
618
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
5,
1,
2,
22
] | 4 | true | Family | Diaminopimelate epimerase, DapF | Diaminopimelate epimerase, DapF | DAP_epimerase_DapF | 6 |
IPR001654 | 1,654 | Marek's disease glycoprotein A | Marek_A | Family | 32 | false | false | Herpesviruses have been implicated as a cause of tumours in a number of species. The common tumour condition of the fowl is caused by Meleagrid herpesvirus 1 (MeHV-1). Although infection is ubiquitous, only a proportion of fowl develop tumours, and the precise details of the process of tumour induction remains to be el... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR00675"
] | [
"MAREKSGPA"
] | [
32
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00003483",
"PUB00005634"
] | [
"2836620",
"2543160"
] | [
"Structure and complete nucleotide sequence of the Marek's disease herpesvirus gp57-65 gene.",
"Nucleotide sequence of the Marek's disease virus (MDV) RB-1B A antigen gene and the identification of the MDV A antigen as the herpes simplex virus-1 glycoprotein C homologue."
] | [
1988,
1989
] | 2 | [
"IPR001038"
] | [] | 1 | 0 | 1 | [
"Mardivirus"
] | [
32
] | 1 | [] | [] | 0 | true | Family | Marek's disease glycoprotein A | Marek's disease glycoprotein A | Marek_A | 9 |
IPR001655 | 1,655 | Neutrophil cytosol factor 1 | P47PHOX | Family | 1,601 | false | false | Phagocytes form the first line of defence against invasion by micro-organisms. Engulfing of bacteria by neutrophils is accompanied by the consumption of large amounts of oxygen - a so-called respiratory burst. Defects in phagocytosis involving the lack of a respiratory burst give rise to chronic granulomatous disease (... | [
"GO:0016176",
"GO:0005737"
] | [
"superoxide-generating NADPH oxidase activator activity",
"cytoplasm"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR00498"
] | [
"P47PHOX"
] | [
1601
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-1222556",
"R-HSA-1236973",
"R-HSA-3299685",
"R-HSA-4420097",
"R-HSA-5668599",
"R-HSA-9013149",
"R-HSA-9013404",
"R-HSA-9013423",
"R-MMU-1222556",
"R-MMU-1236973",
"R-MMU-3299685",
"R-MMU-4420097",
"R-MMU-5668599",
"R-MMU-9013149",
"R-MMU-9013404",
"R-MMU-9013423",
"R-RNO-12225... | [
"REACTOME:R-HSA-1222556",
"REACTOME:R-HSA-1236973",
"REACTOME:R-HSA-3299685",
"REACTOME:R-HSA-4420097",
"REACTOME:R-HSA-5668599",
"REACTOME:R-HSA-9013149",
"REACTOME:R-HSA-9013404",
"REACTOME:R-HSA-9013423",
"REACTOME:R-MMU-1222556",
"REACTOME:R-MMU-1236973",
"REACTOME:R-MMU-3299685",
"REACTOM... | 23 | [
"1gd5",
"1kq6",
"1o7k",
"8wej"
] | 4 | [
"PUB00003781"
] | [
"8796870"
] | [
"The NADPH oxidase and chronic granulomatous disease."
] | [
1996
] | 1 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1601
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
13,
7,
7,
7
] | 4 | true | Family | Neutrophil cytosol factor 1 | Neutrophil cytosol factor 1 | P47PHOX | 2 |
IPR001656 | 1,656 | Pseudouridine synthase, TruD | PsdUridine_synth_TruD | Family | 14,680 | false | false | Pseudouridine synthase TruD modifies uracil-13 in tRNA [ ]. TruD belongs to a large family of pseudouridine synthases present in all kingdoms of life [ ]. It folds into a V-shaped molecule with an RNA-binding cleft formed between its two domains: a catalytic domain and an insertion domain. The catalytic domain differs ... | [
"GO:0003723",
"GO:0009982",
"GO:0001522",
"GO:0009451"
] | [
"RNA binding",
"pseudouridine synthase activity",
"pseudouridine synthesis",
"RNA modification"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"biological_process"
] | 4 | [
"HAMAP",
"PFAM",
"PIRSF",
"PANTHER",
"NCBIFAM"
] | [
"MF_01082",
"PF01142",
"PIRSF037016",
"PTHR13326",
"TIGR00094"
] | [
"TruD",
"TruD",
"Pseudouridin_synth_euk_prd",
"",
"tRNA_TruD_broad"
] | [
6887,
14241,
6738,
8606,
8691
] | 5 | [
"EC",
"PROSITEDOC",
"REACTOME"
] | [
"5.4.99.27",
"PDOC00975",
"R-HSA-6782315"
] | [
"EC:5.4.99.27",
"PROSITEDOC:PDOC00975",
"REACTOME:R-HSA-6782315"
] | 3 | [
"1sb7",
"1si7",
"1szw",
"1z2z",
"5kkp",
"6yxx",
"6yxy",
"7am2",
"7aoi",
"7mzv"
] | 10 | [
"PUB00014308",
"PUB00015731",
"PUB00015813",
"PUB00045922",
"PUB00092579"
] | [
"12756329",
"15135053",
"15208439",
"10529181",
"19664587"
] | [
"A novel unanticipated type of pseudouridine synthase with homologs in bacteria, archaea, and eukarya.",
"X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold.",
"Crystal structure of the highly divergent pseudouridine synthase TruD reveals a circular permutation of a... | [
2003,
2004,
2004,
1999,
2009
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
987,
6222,
7336,
135
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
5,
1,
16,
1,
1,
9,
5,
1,
9,
8,
1,
1,
31
] | 13 | true | Family | Pseudouridine synthase, TruD | Pseudouridine synthase, TruD | PsdUridine_synth_TruD | 5 |
IPR001657 | 1,657 | Hedgehog protein | Hedgehog | Family | 5,479 | false | false | Hedgehog proteins are a family of secreted signal molecules required for embryonic cell differentiation. They are synthesised as inactive precursors with an N-terminal signalling domain linked to a C-terminal autoprocessing domain. The three-dimensional structure of the autolytic domain of the hedgehog protein of shows... | [
"GO:0007267",
"GO:0007275"
] | [
"cell-cell signaling",
"multicellular organism development"
] | [
"biological_process",
"biological_process"
] | 2 | [
"PIRSF",
"PRINTS"
] | [
"PIRSF009400",
"PR00632"
] | [
"Peptidase_C46",
"SONICHHOG"
] | [
1900,
5466
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-209338",
"R-DME-209471",
"R-DME-5358346",
"R-DME-5362798",
"R-DME-5632681",
"R-DRE-5358346",
"R-DRE-5362798",
"R-DRE-5632681",
"R-GGA-5358346",
"R-GGA-5362798",
"R-GGA-5632681",
"R-HSA-373080",
"R-HSA-5358346",
"R-HSA-5362768",
"R-HSA-5362798",
"R-HSA-5632681",
"R-HSA-5632684"... | [
"REACTOME:R-DME-209338",
"REACTOME:R-DME-209471",
"REACTOME:R-DME-5358346",
"REACTOME:R-DME-5362798",
"REACTOME:R-DME-5632681",
"REACTOME:R-DRE-5358346",
"REACTOME:R-DRE-5362798",
"REACTOME:R-DRE-5632681",
"REACTOME:R-GGA-5358346",
"REACTOME:R-GGA-5362798",
"REACTOME:R-GGA-5632681",
"REACTOME:... | 31 | [
"1at0",
"1vhh",
"2ibg",
"2wfq",
"2wfr",
"2wfx",
"2wg3",
"2wg4",
"3d1m",
"3ho5",
"3k7g",
"3k7h",
"3k7i",
"3k7j",
"3m1n",
"3mxw",
"3n1f",
"3n1g",
"3n1m",
"3n1o",
"3n1p",
"3n1q",
"3n1r",
"4c4m",
"4c4n",
"6dmy",
"6e1h",
"6n7g",
"6n7h",
"6n7k",
"6oev",
"6pjv"... | 43 | [
"PUB00000880",
"PUB00001101",
"PUB00001823",
"PUB00001906",
"PUB00011705"
] | [
"1394430",
"1280560",
"8166882",
"1340474",
"9489693"
] | [
"Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog.",
"Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila.",
"Structure and expression of hedgehog... | [
1992,
1992,
1993,
1992,
1998
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
11,
5468
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
24,
1,
10,
7,
10
] | 6 | true | Family | Hedgehog protein | Hedgehog protein | Hedgehog | 8 |
IPR001658 | 1,658 | Gonadotrophin-releasing hormone receptor family | GphnRH_fam_rcpt | Family | 2,725 | false | false | Gonadotropin-releasing hormone (GnRH), also known as luteinizing hormone releasing hormone (LHRH) and luliberin, is synthesized and released from neurons within the hypothalamus [ ]. GnRH is a regulator of reproductive processes, and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing h... | [
"GO:0016500",
"GO:0007186",
"GO:0016020"
] | [
"protein-hormone receptor activity",
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR00529"
] | [
"GNADOTRPHINR"
] | [
2725
] | 1 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"256",
"R-BTA-375281",
"R-BTA-416476",
"R-HSA-375281",
"R-HSA-416476",
"R-MMU-375281",
"R-MMU-416476",
"R-RNO-375281",
"R-RNO-416476",
"R-SSC-375281",
"R-SSC-416476"
] | [
"IUPHAR:256",
"REACTOME:R-BTA-375281",
"REACTOME:R-BTA-416476",
"REACTOME:R-HSA-375281",
"REACTOME:R-HSA-416476",
"REACTOME:R-MMU-375281",
"REACTOME:R-MMU-416476",
"REACTOME:R-RNO-375281",
"REACTOME:R-RNO-416476",
"REACTOME:R-SSC-375281",
"REACTOME:R-SSC-416476"
] | 11 | [
"7br3",
"9u4w",
"9u4y"
] | 3 | [
"PUB00067443",
"PUB00067444",
"PUB00067445",
"PUB00067446",
"PUB00067447",
"PUB00067448",
"PUB00067449",
"PUB00067456",
"PUB00067457",
"PUB00067458",
"PUB00067459",
"PUB00067460",
"PUB00067461",
"PUB00067462",
"PUB00067463",
"PUB00067464"
] | [
"11041448",
"4938639",
"9894843",
"9419371",
"7534732",
"11713589",
"6291912",
"10734055",
"12591945",
"15059960",
"15561800",
"15613448",
"14726258",
"17237842",
"12072036",
"15306097"
] | [
"Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function.",
"Gonadotropin-releasing hormone: one polypeptide regulates secretion of luteinizing and follicle-stimulating hormones.",
"Direct anticancer activity of gonadotropin-releasing h... | [
2000,
1971,
1998,
1998,
1994,
2001,
1983,
2000,
2003,
2004,
2005,
2004,
2003,
2007,
2002,
2004
] | 16 | [
"IPR000276"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
2725
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
12,
4,
4,
4
] | 4 | true | Family | Gonadotrophin-releasing hormone receptor family | Gonadotrophin-releasing hormone receptor family | GphnRH_fam_rcpt | 8 |
IPR001661 | 1,661 | Glycoside hydrolase, family 37 | Glyco_hydro_37 | Family | 14,734 | false | false | O-Glycosyl hydrolases ( ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ ,... | [
"GO:0004555",
"GO:0005991"
] | [
"alpha,alpha-trehalase activity",
"trehalose metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PRINTS",
"PANTHER"
] | [
"PF01204",
"PR00744",
"PTHR23403"
] | [
"Trehalase",
"GLHYDRLASE37",
""
] | [
13370,
12325,
14478
] | 3 | [
"CAZY",
"EC",
"GP",
"PROSITEDOC",
"REACTOME"
] | [
"GH37",
"3.2.1.28",
"GenProp1564",
"PDOC00717",
"R-HSA-189085"
] | [
"CAZY:GH37",
"EC:3.2.1.28",
"GP:GenProp1564",
"PROSITEDOC:PDOC00717",
"REACTOME:R-HSA-189085"
] | 5 | [
"2jf4",
"2jg0",
"2jjb",
"2wyn",
"3d3i",
"3w7s",
"3w7t",
"3w7u",
"3w7w",
"3w7x",
"5ca3",
"5gw7",
"5jta",
"5m4a",
"5n6n",
"5nis",
"5z66",
"5z6h",
"7e9u",
"7e9x",
"7eaw",
"8afe",
"8afh",
"8afl",
"8afm",
"8ahl",
"8aia",
"8aix",
"8ajb"
] | 29 | [
"PUB00002824",
"PUB00004870",
"PUB00005266"
] | [
"8444853",
"7624375",
"8535779"
] | [
"Molecular analysis of the neutral trehalase gene from Saccharomyces cerevisiae.",
"Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.",
"Structures and mechanisms of glycosyl hydrolases."
] | [
1993,
1995,
1995
] | 3 | [] | [
"IPR023715",
"IPR023720"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
38,
6319,
8340,
37
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
5,
10,
4,
11,
3,
2,
5,
2,
3,
4,
2,
1,
10
] | 13 | true | Family | Glycoside hydrolase, family 37 | Glycoside hydrolase, family 37 | Glyco_hydro_37 | 3 |
IPR001662 | 1,662 | Elongation factor 1B gamma, C-terminal | EF1B_G_C | Domain | 6,687 | false | false | Translation elongation factors are responsible for two main processes during protein synthesis on the ribosome [ , , ]. EF1A (or EF-Tu) is responsible for the selection and binding of the cognate aminoacyl-tRNA to the A-site (acceptor site) of the ribosome. EF2 (or EF-G) is responsible for the translocation of the pept... | [
"GO:0003746",
"GO:0006414"
] | [
"translation elongation factor activity",
"translational elongation"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF00647",
"PS50040",
"SM01183"
] | [
"EF1G",
"EF1G_C",
"EF1G"
] | [
6558,
6625,
6367
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC01001",
"R-DME-156842",
"R-HSA-156842",
"R-HSA-9725370",
"R-MMU-156842",
"R-RNO-156842",
"R-SCE-156842"
] | [
"PROSITEDOC:PDOC01001",
"REACTOME:R-DME-156842",
"REACTOME:R-HSA-156842",
"REACTOME:R-HSA-9725370",
"REACTOME:R-MMU-156842",
"REACTOME:R-RNO-156842",
"REACTOME:R-SCE-156842"
] | 7 | [
"1pbu"
] | 1 | [
"PUB00033951",
"PUB00033952",
"PUB00033953"
] | [
"12932732",
"15922593",
"12762045"
] | [
"Elongation factors in protein biosynthesis.",
"Elongation factors on the ribosome.",
"Structural studies of eukaryotic elongation factors."
] | [
2003,
2005,
2001
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Mimiviridae",
"bird metagenome"
] | [
6,
6671,
9,
1
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
12,
1,
2,
1,
3,
3,
1,
7,
5,
2,
1,
27
] | 12 | true | Domain | Elongation factor 1B gamma, C-terminal | Elongation factor 1B gamma, C-terminal | EF1B_G_C | 8 |
IPR001663 | 1,663 | Aromatic-ring-hydroxylating dioxygenase, alpha subunit | Rng_hydr_dOase-A | Family | 30,500 | false | false | Aromatic ring hydroxylating dioxygenases are multicomponent 1,2-dioxygenase complexes that convert closed-ring structures to non-aromatic cis-diols [ ]. The complex has both hydroxylase and electron transfer components. The hydroxylase component is itself composed of two subunits: an alpha-subunit of about 50kDa, and a... | [
"GO:0051537"
] | [
"2 iron, 2 sulfur cluster binding"
] | [
"molecular_function"
] | 1 | [
"PRINTS",
"PANTHER"
] | [
"PR00090",
"PTHR43756"
] | [
"RNGDIOXGNASE",
""
] | [
27447,
30213
] | 2 | [
"EC"
] | [
"1.14.12"
] | [
"EC:1.14.12"
] | 1 | [
"1eg9",
"1ndo",
"1o7g",
"1o7h",
"1o7m",
"1o7n",
"1o7p",
"1o7w",
"1uli",
"1ulj",
"1uuv",
"1uuw",
"1wql",
"2b1x",
"2b24",
"2bmo",
"2bmq",
"2bmr",
"2ckf",
"2gbw",
"2gbx",
"2hmj",
"2hmk",
"2hml",
"2hmm",
"2hmn",
"2hmo",
"2xr8",
"2xrx",
"2xsh",
"2xso",
"2yfi"... | 73 | [
"PUB00002151"
] | [
"1885518"
] | [
"Nucleotide sequences of the Acinetobacter calcoaceticus benABC genes for benzoate 1,2-dioxygenase reveal evolutionary relationships among multicomponent oxygenases."
] | [
1991
] | 1 | [] | [
"IPR017638",
"IPR017639",
"IPR020875",
"IPR039004"
] | 0 | 4 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"plasmids",
"unclassified sequences"
] | [
197,
25355,
4311,
3,
634
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
6,
2,
4,
6
] | 4 | true | Family | Aromatic-ring-hydroxylating dioxygenase, alpha subunit | Aromatic-ring-hydroxylating dioxygenase, alpha subunit | Rng_hydr_dOase-A | 8 |
IPR001665 | 1,665 | Norovirus peptidase C37 | Norovirus_pept_C37 | Domain | 2,625 | false | false | Noroviruses (NVs, formerly "Norwalk-like viruses"), which belong to the Caliciviridae, are the major causative agents of nonbacterial acute gastroenteritis in humans. The NV genome, which consists of positive-sense, single-stranded RNA, contains three open reading frames (ORFs). The first ORF produces a polyprotein tha... | [
"GO:0004197",
"GO:0006508"
] | [
"cysteine-type endopeptidase activity",
"proteolysis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PRINTS",
"PROFILE"
] | [
"PF05416",
"PR00917",
"PS51537"
] | [
"Peptidase_C37",
"SRSVCYSPTASE",
"NV_3CL_PRO"
] | [
2572,
2390,
2561
] | 3 | [
"EC",
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.7.7.48",
"3.4.22.66",
"3.6.1.15",
"PWY-6545",
"PWY-7184",
"PWY-7185",
"PWY-7198",
"PWY-7210"
] | [
"EC:2.7.7.48",
"EC:3.4.22.66",
"EC:3.6.1.15",
"METACYC:PWY-6545",
"METACYC:PWY-7184",
"METACYC:PWY-7185",
"METACYC:PWY-7198",
"METACYC:PWY-7210"
] | 8 | [
"1wqs",
"2fyq",
"2fyr",
"2iph",
"2lnc",
"2m4g",
"3ur6",
"3ur9",
"4ash",
"4imq",
"4imz",
"4in1",
"4in2",
"4inh",
"4x2v",
"4x2w",
"4x2x",
"4x2y",
"4xbb",
"4xbc",
"4xbd",
"5dg6",
"5dgj",
"5e0g",
"5e0h",
"5e0j",
"5t6d",
"5t6f",
"5t6g",
"5tg1",
"5tg2",
"5wej"... | 75 | [
"PUB00011704",
"PUB00020025",
"PUB00030423",
"PUB00040868",
"PUB00046832",
"PUB00076953"
] | [
"11517925",
"9891971",
"14725770",
"16641296",
"16227288",
"7044372"
] | [
"Evolutionary lines of cysteine peptidases.",
"Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases.",
"The structure of sortase B, a cysteine transpeptidase that tethers surface protein to the Staphylococcus aureus cell wall.",
... | [
2001,
1998,
2004,
2006,
2005,
1982
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses"
] | [
15,
19,
2591
] | 3 | [] | [] | 0 | true | Domain | Norovirus peptidase C37 | Norovirus peptidase C37 | Norovirus_pept_C37 | 2 |
IPR001666 | 1,666 | Phosphatidylinositol transfer protein | PI_transfer | Family | 14,839 | false | false | Phosphatidylinositol transfer proteins (PITPs) are ubiquitous cytosolic proteins that catalyse the transfer of phosphatidylinositol (PI) between membranes [ , , , ]. PITPs are an essential component of the polyphosphoinositide synthesis machinery and is hence required for proper signalling by epidermal growth factor an... | [
"GO:0005548",
"GO:0015914"
] | [
"phospholipid transporter activity",
"phospholipid transport"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PRINTS",
"PANTHER"
] | [
"PR00391",
"PTHR10658"
] | [
"PITRANSFER",
""
] | [
11416,
14780
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-1483196",
"R-DDI-1483196",
"R-DME-1483226",
"R-HSA-1483196",
"R-HSA-1483226",
"R-HSA-418890",
"R-HSA-8950505",
"R-MMU-1483196",
"R-MMU-1483226",
"R-RNO-1483196",
"R-RNO-1483226"
] | [
"REACTOME:R-BTA-1483196",
"REACTOME:R-DDI-1483196",
"REACTOME:R-DME-1483226",
"REACTOME:R-HSA-1483196",
"REACTOME:R-HSA-1483226",
"REACTOME:R-HSA-418890",
"REACTOME:R-HSA-8950505",
"REACTOME:R-MMU-1483196",
"REACTOME:R-MMU-1483226",
"REACTOME:R-RNO-1483196",
"REACTOME:R-RNO-1483226"
] | 11 | [
"1kcm",
"1t27",
"1uw5",
"2a1l",
"8pqo",
"9c38",
"9jtz",
"9jyx",
"9jz1",
"9jzp"
] | 10 | [
"PUB00000922",
"PUB00039104",
"PUB00122266",
"PUB00122281",
"PUB00155085",
"PUB00155086"
] | [
"7774006",
"16274224",
"20332109",
"10531358",
"18636990",
"22822086"
] | [
"Signal transduction and membrane traffic: the PITP/phosphoinositide connection.",
"Structure of PITPbeta in complex with phosphatidylcholine: comparison of structure and lipid transfer to other PITP isoforms.",
"Phosphatidylinositol- and phosphatidylcholine-transfer activity of PITPbeta is essential for COPI-m... | [
1995,
2005,
2010,
1999,
2008,
2012
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Megaviricetes"
] | [
167,
14669,
3
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
3,
34,
15,
36,
26,
5,
28,
6
] | 8 | true | Family | Phosphatidylinositol transfer protein | Phosphatidylinositol transfer protein | PI_transfer | 6 |
IPR001667 | 1,667 | DDH domain | DDH_dom | Domain | 56,933 | false | false | This is a domain of predicted phosphoesterases, including Drosophila prune protein and bacterial RecJ exonuclease [ ]. The RecJ protein of Escherichia coli plays an important role in a number of DNA repair and recombination pathways. RecJ catalyses processive degradation of single-stranded DNA in a 5'-to-3' direction. ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01368"
] | [
"DHH"
] | [
56933
] | 1 | [
"EC",
"METACYC",
"METACYC"
] | [
"3.6.1.1",
"PWY-7805",
"PWY-7807"
] | [
"EC:3.6.1.1",
"METACYC:PWY-7805",
"METACYC:PWY-7807"
] | 3 | [
"1i74",
"1ir6",
"1k20",
"1k23",
"1wpm",
"1wpn",
"1wpp",
"2eb0",
"2enx",
"2haw",
"2iw4",
"2qb6",
"2qb7",
"2qb8",
"2zxo",
"2zxp",
"2zxr",
"3dev",
"3w5w",
"4ls9",
"4py9",
"4rpa",
"5cet",
"5f54",
"5f55",
"5f56",
"5ghr",
"5ghs",
"5ght",
"5ipp",
"5iuf",
"5izo"... | 65 | [
"PUB00005478",
"PUB00007151"
] | [
"9478130",
"10633092"
] | [
"A novel family of predicted phosphoesterases includes Drosophila prune protein and bacterial RecJ exonuclease.",
"A thermostable single-strand DNase from Methanococcus jannaschii related to the RecJ recombination and repair exonuclease from Escherichia coli."
] | [
1998,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
3484,
48811,
3829,
79,
730
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (s... | [
1,
1,
1,
2,
1,
2,
2,
1,
1
] | 9 | true | Domain | DDH domain | DDH domain | DDH_dom | 7 |
IPR001668 | 1,668 | Plasmid recombination enzyme | Mob_Pre | Family | 4,941 | false | false | With some plasmids, recombination can occur in a site specific manner that is independent of RecA. In such cases, the recombination event requires another protein called Pre. Pre is a plasmid recombination enzyme. This protein is also known as Mob (conjugative mobilisation) [ ]. | [
"GO:0003677",
"GO:0006310"
] | [
"DNA binding",
"DNA recombination"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF01076"
] | [
"Mob_Pre"
] | [
4941
] | 1 | [] | [] | [] | 0 | [
"4lvi",
"4lvj",
"4lvk",
"4lvl",
"4lvm",
"5n2q"
] | 6 | [
"PUB00002087"
] | [
"2768188"
] | [
"Region of the streptococcal plasmid pMV158 required for conjugative mobilization."
] | [
1989
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Plasmid pTD1",
"Stenosarchaea group",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
4676,
26,
1,
3,
4,
231
] | 6 | [] | [] | 0 | true | Family | Plasmid recombination enzyme | Plasmid recombination enzyme | Mob_Pre | 7 |
IPR001670 | 1,670 | Alcohol dehydrogenase, iron-type/glycerol dehydrogenase GldA | ADH_Fe/GldA | Domain | 72,847 | false | false | Alcohol dehydrogenase ( ) (ADH) catalyses the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD. Currently three, structurally and catalytically, different types of alcohol dehydrogenases are known: Zinc-containing 'long-chain' alcohol dehydrogenases. Insect-type, or 'short-chain' al... | [
"GO:0016491",
"GO:0046872"
] | [
"oxidoreductase activity",
"metal ion binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM"
] | [
"PF00465"
] | [
"Fe-ADH"
] | [
72847
] | 1 | [
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"GenProp0292",
"GenProp0457",
"GenProp0458",
"GenProp0724",
"GenProp0917",
"GenProp1226",
"GenProp1245",
"GenProp1263",
"GenProp1267",
"GenProp1324",
"GenProp1342",
"GenProp1425",
"GenProp1497",
"GenProp1762",
"PDOC00059",
"R-BTA-880009",
"R-CEL-880009",
"R-DDI-880009",
"R-DME-88... | [
"GP:GenProp0292",
"GP:GenProp0457",
"GP:GenProp0458",
"GP:GenProp0724",
"GP:GenProp0917",
"GP:GenProp1226",
"GP:GenProp1245",
"GP:GenProp1263",
"GP:GenProp1267",
"GP:GenProp1324",
"GP:GenProp1342",
"GP:GenProp1425",
"GP:GenProp1497",
"GP:GenProp1762",
"PROSITEDOC:PDOC00059",
"REACTOME:... | 23 | [
"1jpu",
"1jq5",
"1jqa",
"1kq3",
"1o2d",
"1oj7",
"1rrm",
"1ta9",
"1vhd",
"1vlj",
"2bi4",
"2bl4",
"3bfj",
"3hl0",
"3iv7",
"3jzd",
"3owo",
"3ox4",
"3rf7",
"3uhj",
"3w5s",
"3zdr",
"4fr2",
"4mca",
"4qgs",
"5br4",
"5k8c",
"5xn8",
"5yvm",
"5yvr",
"5yvs",
"5zxl"... | 76 | [
"PUB00001606",
"PUB00002060",
"PUB00002085",
"PUB00002196",
"PUB00002203",
"PUB00002240",
"PUB00003722",
"PUB00160956"
] | [
"2015910",
"3584063",
"2661535",
"1644761",
"1385386",
"8132480",
"2823079",
"36928033"
] | [
"Pyruvate-formate-lyase-deactivase and acetyl-CoA reductase activities of Escherichia coli reside on a polymeric protein particle encoded by adhE.",
"Cloning and sequencing of the alcohol dehydrogenase II gene from Zymomonas mobilis.",
"Similarity of Escherichia coli propanediol oxidoreductase (fucO product) an... | [
1991,
1987,
1989,
1992,
1992,
1994,
1987,
2023
] | 8 | [] | [
"IPR034789"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Sym plasmid",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
960,
64065,
7137,
1,
3,
681
] | 6 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
... | [
1,
1,
3,
7,
5,
2,
1,
5,
1,
3
] | 10 | true | Domain | Alcohol dehydrogenase, iron-type/glycerol dehydrogenase GldA | Alcohol dehydrogenase, iron-type/glycerol dehydrogenase GldA | ADH_Fe/GldA | 1 |
IPR001671 | 1,671 | Melanocortin/ACTH receptor | Melcrt_ACTH_rcpt | Family | 8,152 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0004977",
"GO:0007186",
"GO:0016020"
] | [
"melanocortin receptor activity",
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR00534"
] | [
"MCRFAMILY"
] | [
8152
] | 1 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"283",
"R-BTA-375276",
"R-BTA-418555",
"R-DRE-375276",
"R-HSA-375276",
"R-HSA-418555",
"R-HSA-5579031",
"R-HSA-9856649",
"R-MMU-375276",
"R-MMU-418555",
"R-RNO-375276",
"R-SSC-375276",
"R-SSC-418555"
] | [
"IUPHAR:283",
"REACTOME:R-BTA-375276",
"REACTOME:R-BTA-418555",
"REACTOME:R-DRE-375276",
"REACTOME:R-HSA-375276",
"REACTOME:R-HSA-418555",
"REACTOME:R-HSA-5579031",
"REACTOME:R-HSA-9856649",
"REACTOME:R-MMU-375276",
"REACTOME:R-MMU-418555",
"REACTOME:R-RNO-375276",
"REACTOME:R-SSC-375276",
"... | 13 | [
"6w25",
"7aue",
"7f4d",
"7f4f",
"7f4h",
"7f4i",
"7f53",
"7f54",
"7f55",
"7f58",
"7piu",
"7piv",
"8gy7",
"8inr",
"8ioc",
"8iod",
"8kig",
"8qj2",
"8w8w",
"8w8x",
"8w8y",
"8wky",
"8wkz",
"9k3f",
"9k3h",
"9k3k",
"9k3l",
"9k3p"
] | 28 | [
"PUB00000131",
"PUB00002477",
"PUB00004960",
"PUB00004961",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816"
] | [
"2111655",
"2830256",
"8386361",
"8170923",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293"
] | [
"G proteins in signal transduction.",
"G protein involvement in receptor-effector coupling.",
"Design of a discriminating fingerprint for G-protein-coupled receptors.",
"Fingerprinting G-protein-coupled receptors.",
"The G protein-coupled receptor repertoires of human and mouse.",
"GCRDb: a G-protein-coup... | [
1990,
1988,
1993,
1994,
2003,
1994,
2005,
2009,
2006,
2013
] | 10 | [
"IPR000276"
] | [
"IPR000761",
"IPR001168",
"IPR001908"
] | 1 | 3 | 0 | [
"Eumetazoa"
] | [
8152
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
10,
78,
44,
10
] | 4 | true | Family | Melanocortin/ACTH receptor | Melanocortin/ACTH receptor | Melcrt_ACTH_rcpt | 4 |
IPR001673 | 1,673 | Dictyostelium repeat | Dicty_repeat | Repeat | 392 | false | false | This entry represents a short repeat found in dictyostelium proteins. This repeat is composed of a beta hairpin. Structure predictions suggest that the conserved cysteines form disulphide bridges, with one pair forming between adjacent repeats (2 and 3) and one pair within a repeat 1 and 4. This repeat also appears in ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF00526"
] | [
"Dicty_CTDC"
] | [
392
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
6,
143,
238,
5
] | 4 | [] | [] | 0 | true | Repeat | Dictyostelium repeat | Dictyostelium repeat | Dicty_repeat | 9 |
IPR001674 | 1,674 | GMP synthase, C-terminal | GMP_synth_C | Domain | 31,948 | false | false | This entry represents the C-terminal domain of bacterial GMP synthase [glutamine-hydrolyzing] sequences and similar proteins found in all cellular organisms. The amidotransferase family of enzymes utilises the ammonia derived from the hydrolysis of glutamine for a subsequent chemical reaction catalyzed by the same enzy... | [
"GO:0003922",
"GO:0005524",
"GO:0006164",
"GO:0006177"
] | [
"GMP synthase (glutamine-hydrolyzing) activity",
"ATP binding",
"purine nucleotide biosynthetic process",
"GMP biosynthetic process"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"biological_process"
] | 4 | [
"PFAM",
"NCBIFAM",
"CDD"
] | [
"PF00958",
"TIGR00884",
"cd01997"
] | [
"GMP_synt_C",
"guaA_Cterm",
"GMP_synthase_C"
] | [
31625,
28299,
31227
] | 3 | [
"EC",
"GP",
"GP",
"GP",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"6.3.5.2",
"GenProp0696",
"GenProp0697",
"GenProp1650",
"PWY-7221",
"R-CEL-73817",
"R-CEL-9748787",
"R-DDI-73817",
"R-DDI-9748787",
"R-HSA-73817",
"R-HSA-9748787",
"R-MMU-73817",
"R-MMU-9748787",
"R-PFA-73817",
"R-PFA-9748787",
"R-RNO-73817",
"R-RNO-9748787",
"R-SCE-73817",
"R-SC... | [
"EC:6.3.5.2",
"GP:GenProp0696",
"GP:GenProp0697",
"GP:GenProp1650",
"METACYC:PWY-7221",
"REACTOME:R-CEL-73817",
"REACTOME:R-CEL-9748787",
"REACTOME:R-DDI-73817",
"REACTOME:R-DDI-9748787",
"REACTOME:R-HSA-73817",
"REACTOME:R-HSA-9748787",
"REACTOME:R-MMU-73817",
"REACTOME:R-MMU-9748787",
"R... | 21 | [
"1gpm",
"2dpl",
"2vxo",
"2ywb",
"2ywc",
"3a4i",
"3tqi",
"3uow",
"4wim",
"4wio",
"5tw7",
"6jp9",
"7mo6",
"7sbc",
"7zu9"
] | 15 | [
"PUB00003933",
"PUB00006448"
] | [
"8548458",
"10387030"
] | [
"The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families.",
"The amidotransferase family of enzymes: molecular machines for the production and delivery of ammonia."
] | [
1996,
1999
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
893,
25237,
5158,
6,
654
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
6,
1,
1,
2,
1,
4,
2,
1,
3,
7,
1,
1,
4
] | 13 | true | Domain | GMP synthase, C-terminal | GMP synthase, C-terminal | GMP_synth_C | 4 |
IPR001675 | 1,675 | Glycosyl transferase family 29 | Glyco_trans_29 | Family | 30,709 | false | false | Glycosyltransferase family 29 ( ) comprises enzymes with a number of known activities; sialyltransferase ( ), beta-galactosamide alpha-2,6-sialyltransferase ( ), alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase ( ), beta-galactoside alpha-2,3-sialyltransferase ( ), N-acetyllactosaminide alpha-2,3-sialyltransfe... | [
"GO:0008373",
"GO:0009101"
] | [
"sialyltransferase activity",
"glycoprotein biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF00777"
] | [
"Glyco_transf_29"
] | [
30709
] | 1 | [
"CAZY",
"EC",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"GT29",
"2.4.3",
"GenProp1304",
"GenProp1517",
"GenProp1518",
"GenProp1524",
"GenProp1539",
"GenProp1712",
"R-BTA-2022854",
"R-BTA-4085001",
"R-BTA-9037629",
"R-GGA-2022854",
"R-GGA-4085001",
"R-GGA-977068",
"R-HSA-1912420",
"R-HSA-2022854",
"R-HSA-3656243",
"R-HSA-4085001",
"R-H... | [
"CAZY:GT29",
"EC:2.4.3",
"GP:GenProp1304",
"GP:GenProp1517",
"GP:GenProp1518",
"GP:GenProp1524",
"GP:GenProp1539",
"GP:GenProp1712",
"REACTOME:R-BTA-2022854",
"REACTOME:R-BTA-4085001",
"REACTOME:R-BTA-9037629",
"REACTOME:R-GGA-2022854",
"REACTOME:R-GGA-4085001",
"REACTOME:R-GGA-977068",
... | 41 | [
"2wml",
"2wnb",
"2wnf",
"4js1",
"4js2",
"4mps",
"5bo6",
"5bo7",
"5bo8",
"5bo9",
"5cxy",
"6apj",
"6apl",
"6qvs",
"6qvt"
] | 15 | [
"PUB00009409"
] | [
"9334165"
] | [
"A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities."
] | [
1997
] | 1 | [] | [
"IPR012163",
"IPR044782"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
3,
463,
30211,
23,
9
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
14,
114,
3,
112,
82,
7,
70,
31
] | 8 | true | Family | Glycosyl transferase family 29 | Glycosyl transferase family 29 | Glyco_trans_29 | 2 |
IPR001676 | 1,676 | Picornavirus capsid | Picornavirus_capsid | Domain | 54,632 | false | false | This domain occurs in the capsid proteins of picornaviruses, which are non-enveloped plus-strand ssRNA animal viruses with icosahedral capsids. They include rhinovirus (common cold) and poliovirus. The capsid coat protein composition of picornaviruses consists of multiple structural proteins arranged to form an icosahe... | [
"GO:0005198"
] | [
"structural molecule activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF00073"
] | [
"Rhv"
] | [
54632
] | 1 | [
"EC",
"EC",
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.7.7.48",
"3.4.22",
"3.4.22.28",
"3.6.1.15",
"PWY-6545",
"PWY-7184",
"PWY-7185",
"PWY-7198",
"PWY-7210"
] | [
"EC:2.7.7.48",
"EC:3.4.22",
"EC:3.4.22.28",
"EC:3.6.1.15",
"METACYC:PWY-6545",
"METACYC:PWY-7184",
"METACYC:PWY-7185",
"METACYC:PWY-7198",
"METACYC:PWY-7210"
] | 9 | [
"1al2",
"1ar6",
"1ar7",
"1ar8",
"1ar9",
"1asj",
"1aym",
"1ayn",
"1b35",
"1bbt",
"1bev",
"1c8m",
"1cov",
"1d3e",
"1d3i",
"1d4m",
"1dgi",
"1eah",
"1ev1",
"1fmd",
"1fod",
"1fpn",
"1h8t",
"1hri",
"1hrv",
"1hxs",
"1jew",
"1k5m",
"1m11",
"1mec",
"1mqt",
"1na1"... | 589 | [
"PUB00024682",
"PUB00080087",
"PUB00080088",
"PUB00161718"
] | [
"10089503",
"10729171",
"10753813",
"25184560"
] | [
"Structure determination of echovirus 1.",
"An antiviral compound that blocks structural transitions of poliovirus prevents receptor binding at low temperatures.",
"Theoretical studies of viral capsid proteins.",
"Picornavirus morphogenesis."
] | [
1998,
2000,
2000,
2014
] | 4 | [
"IPR033703"
] | [
"IPR004080"
] | 1 | 1 | 0 | [
"Eukaryota",
"Pseudomonadati",
"Viruses",
"viral metagenome"
] | [
41,
3,
54587,
1
] | 4 | [] | [] | 0 | true | Domain | Picornavirus capsid | Picornavirus capsid | Picornavirus_capsid | 3 |
IPR001677 | 1,677 | Transferrin-binding protein B, C-lobe/N-lobe beta-barrel domain | TbpB_B_D | Domain | 1,840 | false | false | This domain is found in the N- and C-terminal lobe of Transferrin-binding protein B. It is also found in Neisserial heparin-binding protein (NHBA) that is responsible for capturing host heparin, a natural glycosaminoglycan. These domains have been structurally characterised , [ , ]. Bacterial lipoproteins represent a l... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01298"
] | [
"TbpB_B_D"
] | [
1840
] | 1 | [] | [] | [] | 0 | [
"2lfu",
"3hoe",
"3hol",
"3pqs",
"3pqu",
"3uaq",
"3v8u",
"3ve1",
"3ve2",
"4o3w",
"4o3x",
"4o3y",
"4o3z",
"4o49",
"4o4u",
"4o4x",
"4qq1",
"4u9c",
"5kkx",
"5o1r",
"6cuj",
"7jrd",
"7n88"
] | 23 | [
"PUB00048808",
"PUB00061391",
"PUB00085044",
"PUB00151924"
] | [
"18186471",
"19716795",
"25800619",
"30133484"
] | [
"The solution structure of the outer membrane lipoprotein OmlA from Xanthomonas axonopodis pv. citri reveals a protein fold implicated in protein-protein interaction.",
"Insights into the bacterial transferrin receptor: the structure of transferrin-binding protein B from Actinobacillus pleuropneumoniae.",
"Patt... | [
2008,
2009,
2015,
2018
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
1831,
9
] | 2 | [] | [] | 0 | true | Domain | Transferrin-binding protein B, C-lobe/N-lobe beta-barrel domain | Transferrin-binding protein B, C-lobe/N-lobe beta-barrel domain | TbpB_B_D | 1 |
IPR001678 | 1,678 | SAM-dependent methyltransferase RsmB-F/NOP2-type domain | MeTrfase_RsmB-F_NOP2_dom | Domain | 63,267 | false | false | This domain is found in a group of class I-like SAM-binding methyltransferases from all cellular organisms. It includes the catalytic core of this enzimes ( ). The catalytic domain of ribosomal RNA cysteine methyltransferases is highly conserved in archaeal, bacterial and eukaryotic proteins [ ]. It is located at the C... | [
"GO:0008168"
] | [
"methyltransferase activity"
] | [
"molecular_function"
] | 1 | [
"PROFILE"
] | [
"PS51686"
] | [
"SAM_MT_RSMB_NOP"
] | [
63267
] | 1 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.1.1",
"PDOC00888",
"R-HSA-6782315",
"R-HSA-6790901",
"R-HSA-6793080",
"R-HSA-8869496"
] | [
"EC:2.1.1",
"PROSITEDOC:PDOC00888",
"REACTOME:R-HSA-6782315",
"REACTOME:R-HSA-6790901",
"REACTOME:R-HSA-6793080",
"REACTOME:R-HSA-8869496"
] | 6 | [
"1ixk",
"1sqf",
"1sqg",
"2b9e",
"2frx",
"2yxl",
"3a4t",
"3ajd",
"3m4x",
"3m6u",
"3m6v",
"3m6w",
"3m6x",
"4fp9",
"4fzv",
"5wwq",
"5wwr",
"5wws",
"5wwt",
"5zvd",
"5zve",
"5zvg",
"5zvh",
"6elz",
"6em5",
"7nac",
"7o9k",
"7o9m",
"7odr",
"7ods",
"7odt",
"7of0"... | 67 | [
"PUB00014219",
"PUB00055250",
"PUB00072550",
"PUB00072551"
] | [
"8972218",
"20558545",
"23913415",
"21123870"
] | [
"Nop2p is required for pre-rRNA processing and 60S ribosome subunit synthesis in yeast.",
"Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus.",
"Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively.",
"Structure of an archaeal homologue of the bacterial Fmu/R... | [
1997,
2010,
2013,
2010
] | 4 | [] | [
"IPR011023"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Heunggongvirae",
"unclassified sequences"
] | [
1176,
35458,
26000,
2,
631
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
51,
6,
32,
7,
2,
18,
14,
3,
24,
24,
3,
4,
70
] | 13 | true | Domain | SAM-dependent methyltransferase RsmB-F/NOP2-type domain | SAM-dependent methyltransferase RsmB-F/NOP2-type domain | MeTrfase_RsmB-F_NOP2_dom | 1 |
IPR001679 | 1,679 | NAD-dependent DNA ligase | DNA_ligase | Family | 29,656 | false | false | DNA ligase (polydeoxyribonucleotide synthase) is the enzyme that joins two DNA fragments by catalyzing the formation of an internucleotide ester bond between phosphate and deoxyribose. It is active during DNA replication, DNA repair and DNA recombination. There are two forms of DNA ligase: one requires ATP ( ), the oth... | [
"GO:0003911",
"GO:0006260",
"GO:0006281"
] | [
"DNA ligase (NAD+) activity",
"DNA replication",
"DNA repair"
] | [
"molecular_function",
"biological_process",
"biological_process"
] | 3 | [
"HAMAP",
"PIRSF",
"NCBIFAM"
] | [
"MF_01588",
"PIRSF001604",
"TIGR00575"
] | [
"DNA_ligase_A",
"LigA",
"dnlj"
] | [
28596,
28724,
27914
] | 3 | [
"EC",
"PROSITEDOC"
] | [
"6.5.1.2",
"PDOC00809"
] | [
"EC:6.5.1.2",
"PROSITEDOC:PDOC00809"
] | 2 | [
"1dgs",
"1v9p",
"2owo",
"3sgi",
"4glx",
"5tt5",
"8ak4"
] | 7 | [
"PUB00001728",
"PUB00002786"
] | [
"1526462",
"8390989"
] | [
"Cloning and molecular characterization of the DNA ligase gene (lig) from Zymomonas mobilis.",
"Guanylate kinase of Escherichia coli K-12."
] | [
1992,
1993
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
347,
28509,
166,
113,
521
] | 5 | [
"Escherichia coli (strain K12)",
"Homo sapiens"
] | [
1,
1
] | 2 | true | Family | NAD-dependent DNA ligase | NAD-dependent DNA ligase | DNA_ligase | 3 |
IPR001680 | 1,680 | WD40 repeat | WD40_rpt | Repeat | 943,433 | false | false | WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs, often terminating in a Trp-Asp (W-D) dipeptide. WD40 repeats usually assume a 7-8 bladed β-propeller fold, but proteins have been found with 4 to 16 repeated units, which also form a circularised β-propeller structure. WD-repea... | [
"GO:0005515"
] | [
"protein binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF00400",
"PS50082",
"SM00320"
] | [
"WD40",
"WD_REPEATS_2",
"WD40"
] | [
710845,
800514,
923950
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00574",
"R-BTA-1296041",
"R-BTA-141430",
"R-BTA-141444",
"R-BTA-1538133",
"R-BTA-156827",
"R-BTA-159227",
"R-BTA-159230",
"R-BTA-159231",
"R-BTA-159236",
"R-BTA-1632852",
"R-BTA-165159",
"R-BTA-166208",
"R-BTA-168638",
"R-BTA-170822",
"R-BTA-174184",
"R-BTA-176409",
"R-BTA-177... | [
"PROSITEDOC:PDOC00574",
"REACTOME:R-BTA-1296041",
"REACTOME:R-BTA-141430",
"REACTOME:R-BTA-141444",
"REACTOME:R-BTA-1538133",
"REACTOME:R-BTA-156827",
"REACTOME:R-BTA-159227",
"REACTOME:R-BTA-159230",
"REACTOME:R-BTA-159231",
"REACTOME:R-BTA-159236",
"REACTOME:R-BTA-1632852",
"REACTOME:R-BTA-1... | 1,414 | [
"1a0r",
"1b9x",
"1b9y",
"1erj",
"1gg2",
"1got",
"1gp2",
"1gxr",
"1k8k",
"1nex",
"1nr0",
"1omw",
"1p22",
"1pev",
"1pgu",
"1pi6",
"1r5m",
"1s4u",
"1sq9",
"1tbg",
"1trj",
"1tyq",
"1u2v",
"1u4c",
"1vyh",
"1xhm",
"1yfq",
"2aq5",
"2b4e",
"2bcj",
"2ce8",
"2ce9"... | 3,287 | [
"PUB00005491",
"PUB00015237",
"PUB00094364"
] | [
"10322433",
"11814058",
"30069656"
] | [
"The WD repeat: a common architecture for diverse functions.",
"WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases.",
"WD40 Repeat Proteins: Signalling Scaffold with Diverse Functions."
] | [
1999,
2001,
2018
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
393,
31122,
911178,
326,
414
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
1218,
191,
1088,
402,
1382,
866,
112,
706,
1172,
95,
115,
2385
] | 12 | true | Repeat | WD40 repeat | WD40 repeat | WD40_rpt | 5 |
IPR001681 | 1,681 | Neurokinin receptor | Neurokn_rcpt | Family | 5,396 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0004995",
"GO:0007186",
"GO:0005886",
"GO:0016020"
] | [
"tachykinin receptor activity",
"G protein-coupled receptor signaling pathway",
"plasma membrane",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component",
"cellular_component"
] | 4 | [
"PRINTS",
"PANTHER"
] | [
"PR00244",
"PTHR46925"
] | [
"NEUROKININR",
""
] | [
4210,
5373
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-380095",
"R-BTA-416476",
"R-CEL-416476",
"R-CEL-8856825",
"R-CEL-8856828",
"R-CFA-380095",
"R-CFA-416476",
"R-CFA-8856825",
"R-CFA-8856828",
"R-HSA-380095",
"R-HSA-416476",
"R-HSA-8856825",
"R-HSA-8856828",
"R-MMU-380095",
"R-MMU-416476",
"R-MMU-8856825",
"R-MMU-8856828",
"R... | [
"REACTOME:R-BTA-380095",
"REACTOME:R-BTA-416476",
"REACTOME:R-CEL-416476",
"REACTOME:R-CEL-8856825",
"REACTOME:R-CEL-8856828",
"REACTOME:R-CFA-380095",
"REACTOME:R-CFA-416476",
"REACTOME:R-CFA-8856825",
"REACTOME:R-CFA-8856828",
"REACTOME:R-HSA-380095",
"REACTOME:R-HSA-416476",
"REACTOME:R-HSA... | 21 | [
"2ks9",
"2ksa",
"2ksb",
"6e59",
"6hll",
"6hlo",
"6hlp",
"6j20",
"6j21",
"7p00",
"7p02",
"7rmg",
"7rmh",
"7rmi",
"7xwo",
"8jbf",
"8u26"
] | 17 | [
"PUB00000131",
"PUB00002477",
"PUB00002518",
"PUB00004960",
"PUB00004961",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816"
] | [
"2111655",
"2830256",
"2478537",
"8386361",
"8170923",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293"
] | [
"G proteins in signal transduction.",
"G protein involvement in receptor-effector coupling.",
"Molecular characterization of a functional cDNA for rat substance P receptor.",
"Design of a discriminating fingerprint for G-protein-coupled receptors.",
"Fingerprinting G-protein-coupled receptors.",
"The G pr... | [
1990,
1988,
1989,
1993,
1994,
2003,
1994,
2005,
2009,
2006,
2013
] | 11 | [
"IPR000276"
] | [
"IPR000046",
"IPR000913",
"IPR001013"
] | 1 | 3 | 0 | [
"Eumetazoa"
] | [
5396
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
45,
5,
13,
8,
6
] | 6 | true | Family | Neurokinin receptor | Neurokinin receptor | Neurokn_rcpt | 9 |
IPR001683 | 1,683 | Phox homology | PX_dom | Domain | 111,998 | false | false | The PX (phox) domain [ ] occurs in a variety of eukaryotic proteins and has been implicated in highly diverse functions, including cell signalling, vesicular trafficking, protein sorting and lipid modification [ , , , ]. PX domains are important phosphoinositide-binding modules that exhibit varying lipid-binding specif... | [
"GO:0035091"
] | [
"phosphatidylinositol binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF00787",
"PS50195",
"SM00312"
] | [
"PX",
"PX",
"PX"
] | [
109163,
106067,
91062
] | 3 | [
"GP",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"GenProp1758",
"PDOC50195",
"R-BTA-3238698",
"R-BTA-432722",
"R-CEL-432722",
"R-CEL-8856828",
"R-DME-6811434",
"R-DME-983189",
"R-HSA-1222556",
"R-HSA-1236973",
"R-HSA-1483148",
"R-HSA-1483166",
"R-HSA-1660499",
"R-HSA-1660514",
"R-HSA-1660516",
"R-HSA-1660517",
"R-HSA-2029485",
"R... | [
"GP:GenProp1758",
"PROSITEDOC:PDOC50195",
"REACTOME:R-BTA-3238698",
"REACTOME:R-BTA-432722",
"REACTOME:R-CEL-432722",
"REACTOME:R-CEL-8856828",
"REACTOME:R-DME-6811434",
"REACTOME:R-DME-983189",
"REACTOME:R-HSA-1222556",
"REACTOME:R-HSA-1236973",
"REACTOME:R-HSA-1483148",
"REACTOME:R-HSA-14831... | 107 | [
"1gd5",
"1h6h",
"1kmd",
"1kq6",
"1o7k",
"1ocs",
"1ocu",
"1xte",
"1xtn",
"2ar5",
"2csk",
"2czo",
"2dyb",
"2ett",
"2i4k",
"2iwl",
"2l73",
"2mxc",
"2rai",
"2raj",
"2rak",
"2rea",
"2red",
"2v14",
"2v6v",
"2wwe",
"2yps",
"3dyt",
"3dyu",
"3fog",
"3hpb",
"3hpc"... | 87 | [
"PUB00005042",
"PUB00006581",
"PUB00007152",
"PUB00008032",
"PUB00010010",
"PUB00011220",
"PUB00020786",
"PUB00020788",
"PUB00020791",
"PUB00068936",
"PUB00084390",
"PUB00084407",
"PUB00101856",
"PUB00163290",
"PUB00163291",
"PUB00163292",
"PUB00163293"
] | [
"8931154",
"9687503",
"11884510",
"11373621",
"12461558",
"12356722",
"15263065",
"11736640",
"10782093",
"17101778",
"16782399",
"17994011",
"32513819",
"21725319",
"22041890",
"23416069",
"33468622"
] | [
"Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3-kinases: binding partners of SH3 domains?",
"A new method for isolating tyrosine kinase substrates used to identify fish, an SH3 and PX domain-containing protein, and Src substrate.",
"The PX domain: a new phosphoinositide-binding module.",
... | [
1996,
1998,
2002,
2001,
2002,
2002,
2004,
2001,
2000,
2007,
2006,
2007,
2020,
2011,
2011,
2013,
2021
] | 17 | [] | [
"IPR034901",
"IPR034902",
"IPR034909",
"IPR034912",
"IPR035550",
"IPR035703",
"IPR035704",
"IPR037426",
"IPR037436",
"IPR037437",
"IPR037833",
"IPR037868",
"IPR037899",
"IPR037900",
"IPR037901",
"IPR037903",
"IPR037904",
"IPR037907",
"IPR037909",
"IPR037911",
"IPR037916",
"... | 0 | 33 | 0 | [
"Archaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18)",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1,
10,
111985,
2
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
48,
20,
156,
34,
225,
153,
13,
21,
232,
15,
14,
73
] | 12 | true | Domain | Phox homology | Phox homology | PX_dom | 3 |
IPR001684 | 1,684 | Large ribosomal subunit protein bL27 | Ribosomal_bL27 | Family | 29,304 | false | false | Large ribosomal subunit protein bL27 (known as L27) is a protein from the large (50S) subunit; it is essential for ribosome function, but its exact role is unclear. It belongs to a family of ribosomal proteins, examples of which are found in bacteria, chloroplasts of plants and red algae and the mitochondria of fungi (... | [
"GO:0003735",
"GO:0006412",
"GO:0005840"
] | [
"structural constituent of ribosome",
"translation",
"ribosome"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"HAMAP",
"PFAM",
"PRINTS",
"PANTHER",
"NCBIFAM"
] | [
"MF_00539",
"PF01016",
"PR00063",
"PTHR15893",
"TIGR00062"
] | [
"Ribosomal_bL27",
"Ribosomal_L27",
"RIBOSOMALL27",
"",
"L27"
] | [
24043,
29292,
28571,
28929,
25675
] | 5 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC00652",
"R-HSA-5368286",
"R-HSA-5389840",
"R-HSA-5419276",
"R-HSA-9937383",
"R-MMU-5389840",
"R-MMU-5419276",
"R-MMU-9937383"
] | [
"PROSITEDOC:PDOC00652",
"REACTOME:R-HSA-5368286",
"REACTOME:R-HSA-5389840",
"REACTOME:R-HSA-5419276",
"REACTOME:R-HSA-9937383",
"REACTOME:R-MMU-5389840",
"REACTOME:R-MMU-5419276",
"REACTOME:R-MMU-9937383"
] | 8 | [
"1nkw",
"1nwx",
"1nwy",
"1sm1",
"1v8q",
"1vvj",
"1vy4",
"1vy5",
"1vy6",
"1vy7",
"1xbp",
"1y69",
"2ftc",
"2j28",
"2rdo",
"2zjp",
"2zjq",
"2zjr",
"3bbx",
"3cf5",
"3dll",
"3iy9",
"3j5l",
"3j6b",
"3j7y",
"3j7z",
"3j8g",
"3j9m",
"3j9w",
"3j9y",
"3j9z",
"3ja1"... | 1,232 | [
"PUB00007068",
"PUB00007069",
"PUB00007070"
] | [
"11297922",
"11290319",
"11114498"
] | [
"Atomic structures at last: the ribosome in 2000.",
"The ribosome in focus.",
"The end of the beginning: structural studies of ribosomal proteins."
] | [
2001,
2001,
2000
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Pyrodictium abyssi",
"unclassified sequences"
] | [
23206,
5611,
1,
486
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
11,
1,
1,
4,
1,
5,
1,
1,
8,
3,
1,
1,
14
] | 13 | true | Family | Large ribosomal subunit protein bL27 | Large ribosomal subunit protein bL27 | Ribosomal_bL27 | 3 |
IPR001686 | 1,686 | Peptidase A22A, presenilin, nematode type | Pept_A22A_Ceel | Family | 10 | false | false | This entry includes a group of aspartic peptidases belong to MEROPS peptidase family A22 (presenilin family, clan AD), subfamily A22A (the type example is human presenilin 1) from nematodes. Presenilins are polytopic transmembrane (TM) proteins, mutations in which are associated with the occurrence of early-onset famil... | [
"GO:0042500",
"GO:0007399",
"GO:0018991",
"GO:0016020"
] | [
"aspartic endopeptidase activity, intramembrane cleaving",
"nervous system development",
"egg-laying behavior",
"membrane"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PRINTS"
] | [
"PR01075"
] | [
"PRESENILNSEL"
] | [
10
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-CEL-1251985",
"R-CEL-3928665"
] | [
"REACTOME:R-CEL-1251985",
"REACTOME:R-CEL-3928665"
] | 2 | [] | 0 | [
"PUB00000093",
"PUB00000349",
"PUB00000522",
"PUB00000974",
"PUB00001330",
"PUB00002010",
"PUB00004220",
"PUB00011023",
"PUB00011707",
"PUB00021296",
"PUB00042504",
"PUB00054916",
"PUB00065205",
"PUB00066803",
"PUB00076784",
"PUB00076785",
"PUB00076786",
"PUB00153721"
] | [
"2194475",
"1851433",
"8439290",
"9791530",
"6795036",
"9521418",
"7566091",
"10331925",
"11566868",
"10864493",
"2682266",
"10917532",
"23254940",
"21765428",
"4912600",
"10497172",
"21751400",
"27661254"
] | [
"The structure and function of the aspartic proteinases.",
"Structural and evolutionary relationships between retroviral and eucaryotic aspartic proteinases.",
"Evolutionary families of peptidases.",
"Introduction: genetic determinants of mid- and late-life dementias.",
"Gastric proteinases--structure, func... | [
1990,
1991,
1993,
1998,
1981,
1998,
1995,
1999,
2001,
2000,
1989,
2000,
2013,
2011,
1970,
1999,
2011,
2016
] | 18 | [
"IPR001108"
] | [] | 1 | 0 | 1 | [
"Caenorhabditis"
] | [
10
] | 1 | [
"Caenorhabditis elegans"
] | [
1
] | 1 | true | Family | Peptidase A22A, presenilin, nematode type | Peptidase A22A, presenilin, nematode type | Pept_A22A_Ceel | 7 |
IPR001688 | 1,688 | GPCR, family 2, calcitonin receptor | GPCR_2_calcitonin_rcpt | Family | 1,076 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0004948",
"GO:0016020"
] | [
"calcitonin receptor activity",
"membrane"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR00361"
] | [
"CALCITONINR"
] | [
1076
] | 1 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"43",
"R-HSA-418555",
"R-HSA-419812",
"R-MMU-418555",
"R-MMU-419812",
"R-RNO-419812",
"R-SSC-418555",
"R-SSC-419812"
] | [
"IUPHAR:43",
"REACTOME:R-HSA-418555",
"REACTOME:R-HSA-419812",
"REACTOME:R-MMU-418555",
"REACTOME:R-MMU-419812",
"REACTOME:R-RNO-419812",
"REACTOME:R-SSC-418555",
"REACTOME:R-SSC-419812"
] | 8 | [
"5ii0",
"5uz7",
"6niy",
"7tyf",
"7tyh",
"7tyi",
"7tyl",
"7tyn",
"7tyo",
"7tyw",
"7tyx",
"7tyy",
"7tzf",
"8f0j",
"8f0k",
"8f2a",
"8f2b",
"9auc",
"9blb",
"9blc",
"9blw",
"9bp3",
"9bq3",
"9btw",
"9bub",
"9buc",
"9bud",
"9bue"
] | 28 | [
"PUB00001208",
"PUB00004310",
"PUB00004961",
"PUB00005147",
"PUB00005148",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816"
] | [
"1646711",
"1314625",
"8170923",
"1658940",
"1658941",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293"
] | [
"Molecular cloning and expression of a cDNA encoding the secretin receptor.",
"Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide.",
"Fingerprinting G-protein-coupled receptors.",
"Expression cloning of an adenylate cyclase-coupled calcitonin receptor.",
... | [
1991,
1992,
1994,
1991,
1991,
2003,
1994,
2005,
2009,
2006,
2013
] | 11 | [
"IPR003287"
] | [] | 1 | 0 | 1 | [
"Vertebrata"
] | [
1076
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
5,
5,
7
] | 4 | true | Family | GPCR, family 2, calcitonin receptor | GPCR, family 2, calcitonin receptor | GPCR_2_calcitonin_rcpt | 4 |
IPR001689 | 1,689 | Flagellar motor switch protein FliM | Flag_FliM | Family | 10,684 | false | false | The flagellar motor switch in Escherichia coli and Salmonella typhimurium regulates the direction of flagellar rotation and hence controls swimming behaviour [ ]. The switch is a complex apparatus that responds to signals transduced by the chemotaxis sensory signalling system during chemotactic behaviour [ ]. CheY, the... | [
"GO:0003774",
"GO:0071973",
"GO:0009425"
] | [
"cytoskeletal motor activity",
"bacterial-type flagellum-dependent cell motility",
"bacterial-type flagellum basal body"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PIRSF",
"PRINTS",
"NCBIFAM",
"CDD"
] | [
"PIRSF002888",
"PR00955",
"TIGR01397",
"cd17908"
] | [
"FliM",
"FLGMOTORFLIM",
"fliM_switch",
"FliM"
] | [
9488,
9519,
8918,
10666
] | 4 | [
"GP",
"GP",
"GP"
] | [
"GenProp0883",
"GenProp1183",
"GenProp1194"
] | [
"GP:GenProp0883",
"GP:GenProp1183",
"GP:GenProp1194"
] | 3 | [
"2hp7",
"3soh",
"4fhr",
"4fq0",
"4gc8",
"4qrm",
"5x0z",
"7dm9",
"7dma",
"8umd",
"8umx",
"8uox",
"8upl",
"8vib",
"8vid",
"8vkq",
"8vkr",
"8wiw",
"8wo5",
"8woe",
"8xp0",
"8xp1",
"8yjt",
"9n49",
"9n4z"
] | 25 | [
"PUB00001834",
"PUB00002083",
"PUB00002290",
"PUB00004790"
] | [
"8224881",
"2656645",
"8631704",
"1631122"
] | [
"Gene sequence, overproduction, purification and determination of the wild-type level of the Escherichia coli flagellar switch protein FliG.",
"Flagellar switch of Salmonella typhimurium: gene sequences and deduced protein sequences.",
"A mutational analysis of the interaction between FliG and FliM, two compone... | [
1993,
1989,
1996,
1992
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
10538,
13,
133
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Flagellar motor switch protein FliM | Flagellar motor switch protein FliM | Flag_FliM | 1 |
IPR001690 | 1,690 | Autoinducer synthase | Autoind_synthase | Family | 4,994 | false | false | Bacterial species have many methods of controlling gene expression and cell growth. Regulation of gene expression in response to changes in cell density is termed quorum sensing [ , ]. Quorum-sensing bacteria produce, release and respond to hormone-like molecules (autoinducers) that accumulate in the external environme... | [
"GO:0016740"
] | [
"transferase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PRINTS",
"PROFILE",
"PANTHER"
] | [
"PF00765",
"PR01549",
"PS51187",
"PTHR39322"
] | [
"Autoind_synth",
"AUTOINDCRSYN",
"AUTOINDUCER_SYNTH_2",
""
] | [
4880,
4362,
4898,
4871
] | 4 | [
"EC",
"METACYC",
"PROSITEDOC"
] | [
"2.3.1.184",
"PWY-6157",
"PDOC00731"
] | [
"EC:2.3.1.184",
"METACYC:PWY-6157",
"PROSITEDOC:PDOC00731"
] | 3 | [
"1k4j",
"1kzf",
"1ro5",
"3p2f",
"3p2h",
"5w8a",
"5w8c",
"5w8d",
"5w8e",
"5w8g",
"6wn0",
"6wns"
] | 12 | [
"PUB00003852",
"PUB00007153",
"PUB00007154",
"PUB00007155",
"PUB00007156"
] | [
"7968529",
"10607620",
"9990077",
"8188582",
"3697093"
] | [
"A novel strategy for the isolation of luxI homologues: evidence for the widespread distribution of a LuxR:LuxI superfamily in enteric bacteria.",
"How bacteria talk to each other: regulation of gene expression by quorum sensing.",
"Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi:... | [
1993,
1999,
1999,
1994,
1987
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
4946,
2,
13,
33
] | 4 | [] | [] | 0 | true | Family | Autoinducer synthase | Autoinducer synthase | Autoind_synthase | 7 |
IPR001693 | 1,693 | Calcitonin peptide-like | Calcitonin_peptide-like | Domain | 2,418 | false | false | Calcitonin [ ] is a 32 amino acid polypeptide hormone that causes a rapid but short-lived drop in the level of calcium and phosphate in the blood, by promoting the incorporation of these ions in the bones. This is the alpha type. Alternative splicing of the gene coding for calcitonin produces a distantly related peptid... | [
"GO:0005179",
"GO:0005576"
] | [
"hormone activity",
"extracellular region"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"SMART"
] | [
"SM00113"
] | [
"CALCITONIN"
] | [
2418
] | 1 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC00231",
"R-CFA-419812",
"R-HSA-210745",
"R-HSA-418555",
"R-HSA-419812",
"R-HSA-977225",
"R-MMU-418555",
"R-MMU-419812",
"R-RNO-419812",
"R-SSC-418555",
"R-SSC-419812"
] | [
"PROSITEDOC:PDOC00231",
"REACTOME:R-CFA-419812",
"REACTOME:R-HSA-210745",
"REACTOME:R-HSA-418555",
"REACTOME:R-HSA-419812",
"REACTOME:R-HSA-977225",
"REACTOME:R-MMU-418555",
"REACTOME:R-MMU-419812",
"REACTOME:R-RNO-419812",
"REACTOME:R-SSC-418555",
"REACTOME:R-SSC-419812"
] | 11 | [
"1bku",
"1byv",
"1bzb",
"1fb9",
"2g48",
"2glg",
"2glh",
"2jxz",
"2kb8",
"2kj7",
"2l86",
"3g7v",
"3hgz",
"5k5g",
"5mgq",
"6e3y",
"6niy",
"6ucj",
"6uck",
"6vw2",
"6y1a",
"6zrf",
"6zrq",
"6zrr",
"7bg0",
"7knu",
"7m61",
"7m62",
"7m64",
"7m65",
"7tyf",
"7tyh"... | 85 | [
"PUB00000472",
"PUB00002606"
] | [
"3060108",
"2407732"
] | [
"Peptides from the calcitonin genes: molecular genetics, structure and function.",
"Islet amyloid polypeptide. A new beta cell secretory product related to islet amyloid deposits."
] | [
1988,
1990
] | 2 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
2418
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
26,
7,
8,
12
] | 4 | true | Domain | Calcitonin peptide-like | Calcitonin peptide-like | Calcitonin_peptide-like | 2 |
IPR001694 | 1,694 | NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H | NADH_UbQ_OxRdtase_su1/FPO | Family | 94,431 | false | false | This entry represents subunit 1 NADH:ubiquinone oxidoreductase [ ]. Among the many polypeptide subunits that make up complex I, there are fifteen which are located in the membrane part, seven of which are encoded by the mitochondrial and chloroplast genomes of most species. The most conserved of these organelle-encoded... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"HAMAP",
"PFAM",
"PANTHER"
] | [
"MF_01350",
"PF00146",
"PTHR11432"
] | [
"NDH1_NuoH",
"NADHdh",
""
] | [
64916,
94409,
87111
] | 3 | [
"EC",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"7.1.1.-",
"GenProp0135",
"GenProp1198",
"GenProp1230",
"GenProp1254",
"GenProp1267",
"GenProp1341",
"GenProp1496",
"GenProp1537",
"GenProp1583",
"GenProp1608",
"GenProp1637",
"GenProp1751",
"PDOC00570",
"R-CEL-5419276",
"R-DME-5419276",
"R-DME-611105",
"R-DME-6799198",
"R-DRE-61... | [
"EC:7.1.1.-",
"GP:GenProp0135",
"GP:GenProp1198",
"GP:GenProp1230",
"GP:GenProp1254",
"GP:GenProp1267",
"GP:GenProp1341",
"GP:GenProp1496",
"GP:GenProp1537",
"GP:GenProp1583",
"GP:GenProp1608",
"GP:GenProp1637",
"GP:GenProp1751",
"PROSITEDOC:PDOC00570",
"REACTOME:R-CEL-5419276",
"REACT... | 32 | [
"4he8",
"4hea",
"4wz7",
"5gpn",
"5gup",
"5lc5",
"5ldw",
"5ldx",
"5lnk",
"5o31",
"5xtc",
"5xtd",
"5xth",
"5xti",
"6cfw",
"6g2j",
"6g72",
"6gcs",
"6h8k",
"6hum",
"6i0d",
"6i1p",
"6khi",
"6khj",
"6l7o",
"6l7p",
"6nbq",
"6nbx",
"6nby",
"6q8o",
"6q8w",
"6q8x"... | 333 | [
"PUB00001392",
"PUB00003309",
"PUB00005074",
"PUB00043561",
"PUB00045437"
] | [
"2029890",
"7690854",
"1470679",
"10940377",
"18394423"
] | [
"The respiratory-chain NADH dehydrogenase (complex I) of mitochondria.",
"The gene locus of the proton-translocating NADH: ubiquinone oxidoreductase in Escherichia coli. Organization of the 14 genes and relationship between the derived proteins and subunits of mitochondrial complex I.",
"The NADH:ubiquinone oxi... | [
1991,
1993,
1992,
2000,
2008
] | 5 | [] | [
"IPR053455"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Leviviridae sp.",
"unclassified sequences"
] | [
1395,
22952,
69240,
1,
843
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
14,
3,
1,
13,
3,
1004,
8,
1,
9,
6,
6
] | 11 | true | Family | NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H | NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H | NADH_UbQ_OxRdtase_su1/FPO | 8 |
IPR001696 | 1,696 | Voltage gated sodium channel, alpha subunit | Na_channel_asu | Family | 15,704 | false | false | Voltage-dependent sodium channels are transmembrane (TM) proteins responsible for the depolarising phase of the action potential in most electrically excitable cells [ ]. They may exist in 3 states [ ]: the resting state, where the channel is closed; the activated state, where the channel is open; and the inactivated s... | [
"GO:0005248",
"GO:0006814",
"GO:0001518"
] | [
"voltage-gated sodium channel activity",
"sodium ion transport",
"voltage-gated sodium channel complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR00170"
] | [
"NACHANNEL"
] | [
15704
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-445095",
"R-HSA-5576892",
"R-HSA-9717207"
] | [
"REACTOME:R-HSA-445095",
"REACTOME:R-HSA-5576892",
"REACTOME:R-HSA-9717207"
] | 3 | [
"5x0m",
"5xsy",
"6a90",
"6a91",
"6a95",
"6agf",
"6j8e",
"6j8g",
"6j8h",
"6j8i",
"6j8j",
"6lqa",
"6nt3",
"6nt4",
"7dtc",
"7dtd",
"7tj8",
"7tj9",
"7w77",
"7w7f",
"7w9k",
"7w9l",
"7w9m",
"7w9p",
"7w9t",
"7we4",
"7wel",
"7wfr",
"7wfw",
"7xve",
"7xvf",
"8f0p"... | 61 | [
"PUB00000213",
"PUB00003989",
"PUB00004785",
"PUB00096460",
"PUB00096461"
] | [
"1323284",
"6209577",
"1317577",
"21947499",
"27143702"
] | [
"Proposed tertiary structure of the sodium channel.",
"Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence.",
"Molecular cloning of an atypical voltage-gated sodium channel expressed in human heart and uterus: evidence for a distinct gene family.",
"Voltage-gated sodium cha... | [
1992,
1984,
1992,
2012,
2016
] | 5 | [
"IPR043203"
] | [
"IPR008051",
"IPR008052",
"IPR008053",
"IPR008054"
] | 1 | 4 | 0 | [
"Opisthokonta"
] | [
15704
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
39,
57,
34,
39,
45
] | 5 | true | Family | Voltage gated sodium channel, alpha subunit | Voltage gated sodium channel, alpha subunit | Na_channel_asu | 8 |
IPR001697 | 1,697 | Pyruvate kinase | Pyr_Knase | Family | 51,139 | false | false | Pyruvate kinase ( ) (PK) catalyses the final step in glycolysis [ , ], the conversion of phosphoenolpyruvate to pyruvate with concomitant phosphorylation of ADP to ATP: ADP + phosphoenolpyruvate = ATP + pyruvate The enzyme, which is found in all living organisms, requires both magnesium and potassium ions for its activ... | [
"GO:0000287",
"GO:0004743",
"GO:0030955",
"GO:0006096"
] | [
"magnesium ion binding",
"pyruvate kinase activity",
"potassium ion binding",
"glycolytic process"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process"
] | 4 | [
"PRINTS",
"PANTHER",
"NCBIFAM",
"CDD"
] | [
"PR01050",
"PTHR11817",
"TIGR01064",
"cd00288"
] | [
"PYRUVTKNASE",
"",
"pyruv_kin",
"Pyruvate_Kinase"
] | [
47243,
51021,
44223,
10391
] | 4 | [
"EC",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",... | [
"2.7.1.40",
"GenProp0691",
"GenProp1267",
"GenProp1306",
"GenProp1407",
"GenProp1580",
"GenProp1599",
"GenProp1710",
"PWY-1042",
"PWY-2221",
"PWY-5484",
"PWY-5723",
"PWY-6886",
"PWY-6901",
"PWY-7003",
"PWY-7218",
"PWY-7383",
"PWY-8004",
"PWY-8404",
"R-CFA-70171",
"R-CFA-70268... | [
"EC:2.7.1.40",
"GP:GenProp0691",
"GP:GenProp1267",
"GP:GenProp1306",
"GP:GenProp1407",
"GP:GenProp1580",
"GP:GenProp1599",
"GP:GenProp1710",
"METACYC:PWY-1042",
"METACYC:PWY-2221",
"METACYC:PWY-5484",
"METACYC:PWY-5723",
"METACYC:PWY-6886",
"METACYC:PWY-6901",
"METACYC:PWY-7003",
"META... | 56 | [
"1a3w",
"1a3x",
"1a49",
"1a5u",
"1aqf",
"1e0t",
"1e0u",
"1f3w",
"1f3x",
"1pkl",
"1pkm",
"1pkn",
"1pky",
"1t5a",
"1zjh",
"2e28",
"2g50",
"2vgb",
"2vgf",
"2vgg",
"2vgi",
"3bjf",
"3bjt",
"3e0v",
"3e0w",
"3eoe",
"3g2g",
"3gg8",
"3gqy",
"3gr4",
"3h6o",
"3hqn"... | 211 | [
"PUB00000569",
"PUB00014134",
"PUB00014243",
"PUB00024392",
"PUB00100069"
] | [
"2379684",
"11960989",
"12798932",
"10751408",
"29748232"
] | [
"Isoenzymes of pyruvate kinase.",
"Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia.",
"Pyruvate kinase: current status of regulatory and functional properties.",
"The allosteric regulation of pyruvate kinase.",
"An allostatic mechanism for M2 p... | [
1990,
2002,
2003,
2000,
2018
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctNmW2",
"unclassified sequences"
] | [
715,
31291,
18487,
1,
645
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
53,
8,
9,
11,
2,
23,
14,
1,
38,
16,
2,
1,
87
] | 13 | true | Family | Pyruvate kinase | Pyruvate kinase | Pyr_Knase | 6 |
IPR001699 | 1,699 | T-box transcription factor | TF_T-box | Family | 23,274 | false | false | Transcription factors of the T-box family are required both for early cell-fate decisions, such as those necessary for formation of the basic vertebrate body plan, for differentiation and organogenesis [ ] and also have been associated to multiple aspects of development and in adult terminal cell-type differentiation i... | [
"GO:0000978",
"GO:0003700",
"GO:0006355"
] | [
"RNA polymerase II cis-regulatory region sequence-specific DNA binding",
"DNA-binding transcription factor activity",
"regulation of DNA-templated transcription"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PANTHER"
] | [
"PTHR11267"
] | [
""
] | [
23274
] | 1 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00972",
"R-CEL-2032785",
"R-CEL-9856649",
"R-DME-9856649",
"R-DRE-2032785",
"R-GGA-2032785",
"R-HSA-2032785",
"R-HSA-5578768",
"R-HSA-8953750",
"R-HSA-9733709",
"R-HSA-9754189",
"R-HSA-9758919",
"R-HSA-9793380",
"R-HSA-9796292",
"R-HSA-9823730",
"R-HSA-9824272",
"R-HSA-9825892",... | [
"PROSITEDOC:PDOC00972",
"REACTOME:R-CEL-2032785",
"REACTOME:R-CEL-9856649",
"REACTOME:R-DME-9856649",
"REACTOME:R-DRE-2032785",
"REACTOME:R-GGA-2032785",
"REACTOME:R-HSA-2032785",
"REACTOME:R-HSA-5578768",
"REACTOME:R-HSA-8953750",
"REACTOME:R-HSA-9733709",
"REACTOME:R-HSA-9754189",
"REACTOME:... | 25 | [
"1h6f",
"1xbr",
"2x6u",
"2x6v",
"4a04",
"4s0h",
"5bqd",
"5flv",
"5qrf",
"5qrg",
"5qrh",
"5qri",
"5qrj",
"5qrk",
"5qrl",
"5qrm",
"5qrn",
"5qro",
"5qrp",
"5qrq",
"5qrr",
"5qrs",
"5qrt",
"5qru",
"5qrv",
"5qrw",
"5qrx",
"5qry",
"5qrz",
"5qs0",
"5qs1",
"5qs2"... | 65 | [
"PUB00000739",
"PUB00001985",
"PUB00003895",
"PUB00004265",
"PUB00005531",
"PUB00006158",
"PUB00007157",
"PUB00099960",
"PUB00099961"
] | [
"9504043",
"9503012",
"7920656",
"9349824",
"9196325",
"9395282",
"12093383",
"29726930",
"28057261"
] | [
"The T-box gene family.",
"A combined analysis of genomic and primary protein structure defines the phylogenetic relationship of new members if the T-box family.",
"An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus.",
"Crystallographic structure of the... | [
1998,
1998,
1994,
1997,
1997,
1997,
2002,
2018,
2017
] | 9 | [] | [
"IPR002070"
] | 0 | 1 | 0 | [
"Eukaryota",
"bird metagenome"
] | [
23273,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
19,
99,
22,
55,
53,
54
] | 6 | true | Family | T-box transcription factor | T-box transcription factor | TF_T-box | 6 |
IPR001701 | 1,701 | Glycoside hydrolase family 9 | Glyco_hydro_9 | Domain | 23,791 | false | false | O-Glycosyl hydrolases ( ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ ,... | [
"GO:0004553",
"GO:0005975"
] | [
"hydrolase activity, hydrolyzing O-glycosyl compounds",
"carbohydrate metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF00759"
] | [
"Glyco_hydro_9"
] | [
23791
] | 1 | [
"CAZY",
"EC",
"METACYC",
"PROSITEDOC"
] | [
"GH9",
"3.2.1.4",
"PWY-6788",
"PDOC00511"
] | [
"CAZY:GH9",
"EC:3.2.1.4",
"METACYC:PWY-6788",
"PROSITEDOC:PDOC00511"
] | 4 | [
"1clc",
"1g87",
"1ga2",
"1ia6",
"1ia7",
"1js4",
"1k72",
"1kfg",
"1ks8",
"1ksc",
"1ksd",
"1rq5",
"1tf4",
"1ut9",
"2xfg",
"2yik",
"3ez8",
"3gzk",
"3h2w",
"3h3k",
"3h7l",
"3rx5",
"3rx7",
"3rx8",
"3tf4",
"3wc3",
"3x17",
"4cj0",
"4cj1",
"4dod",
"4doe",
"4tf4"... | 57 | [
"PUB00004870",
"PUB00005266"
] | [
"7624375",
"8535779"
] | [
"Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.",
"Structures and mechanisms of glycosyl hydrolases."
] | [
1995,
1995
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
26,
7030,
16475,
1,
259
] | 5 | [
"Arabidopsis thaliana",
"Homo sapiens",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
129,
1,
56,
125
] | 4 | true | Domain | Glycoside hydrolase family 9 | Glycoside hydrolase family 9 | Glyco_hydro_9 | 2 |
IPR001702 | 1,702 | Porin, Gram-negative type | Porin_Gram-ve | Family | 23,824 | false | false | Porins are found in the outer membranes of Gram-negative bacteria, mitochondria and chloroplasts, where they form ion-selective channels for small hydrophilic molecules (up to ~600 D) [ , ]. X-ray structure analyses of several bacterial porins [ , , ] have revealed a large 16-stranded anti-parallel β-barrel structure e... | [
"GO:0015288",
"GO:0034220",
"GO:0009279",
"GO:0016020"
] | [
"porin activity",
"monoatomic ion transmembrane transport",
"cell outer membrane",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component",
"cellular_component"
] | 4 | [
"PFAM",
"PRINTS"
] | [
"PF00267",
"PR00182"
] | [
"Porin_1",
"ECOLNEIPORIN"
] | [
12461,
22479
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1236974",
"R-HSA-166058",
"R-HSA-168179",
"R-HSA-3000484",
"R-HSA-5602498",
"R-HSA-5603041"
] | [
"REACTOME:R-HSA-1236974",
"REACTOME:R-HSA-166058",
"REACTOME:R-HSA-168179",
"REACTOME:R-HSA-3000484",
"REACTOME:R-HSA-5602498",
"REACTOME:R-HSA-5603041"
] | 6 | [
"1bt9",
"1gfm",
"1gfn",
"1gfo",
"1gfp",
"1gfq",
"1hxt",
"1hxu",
"1hxx",
"1mpf",
"1opf",
"1osm",
"1pho",
"2j1n",
"2j4u",
"2omf",
"2xe1",
"2xe2",
"2xe3",
"2xe5",
"2xg6",
"2zfg",
"2zld",
"2zle",
"3a2s",
"3fyx",
"3hw9",
"3hwb",
"3k19",
"3k1b",
"3nb3",
"3nsg"... | 118 | [
"PUB00001604",
"PUB00003334",
"PUB00003475",
"PUB00003829",
"PUB00005073"
] | [
"1707373",
"7525973",
"1725488",
"1373213",
"2178269"
] | [
"The structure of porin from Rhodobacter capsulatus at 1.8 A resolution.",
"Refined structure of the porin from Rhodopseudomonas blastica. Comparison with the porin from Rhodobacter capsulatus.",
"A common channel-forming motif in evolutionarily distant porins.",
"Porins and specific channels of bacterial out... | [
1991,
1994,
1991,
1992,
1990
] | 5 | [] | [
"IPR001897",
"IPR002299"
] | 0 | 2 | 0 | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
23738,
10,
18,
58
] | 4 | [
"Escherichia coli (strain K12)"
] | [
8
] | 1 | true | Family | Porin, Gram-negative type | Porin, Gram-negative type | Porin_Gram-ve | 4 |
IPR001704 | 1,704 | Prepro-orexin | Orexin | Family | 744 | false | false | Orexins (also known as hypocretins) are neuropeptides that are specifically localised to the hypothalamus. They are thought to interact with autonomic, neurendocrine and neuroregulatory systems, and play an important role in the regulation of feeding behaviour [ , ]. When applied to hypothalamic neurones, these peptide... | [
"GO:0007218",
"GO:0007631"
] | [
"neuropeptide signaling pathway",
"feeding behavior"
] | [
"biological_process",
"biological_process"
] | 2 | [
"PFAM",
"PIRSF",
"PRINTS",
"PANTHER"
] | [
"PF02072",
"PIRSF037824",
"PR01091",
"PTHR15173"
] | [
"Orexin",
"Orexin",
"OREXINPP",
""
] | [
743,
126,
563,
733
] | 4 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-389397",
"R-BTA-416476",
"R-CFA-389397",
"R-CFA-416476",
"R-HSA-389397",
"R-HSA-416476",
"R-MMU-389397",
"R-MMU-416476",
"R-RNO-389397",
"R-RNO-416476",
"R-SSC-389397",
"R-SSC-416476"
] | [
"REACTOME:R-BTA-389397",
"REACTOME:R-BTA-416476",
"REACTOME:R-CFA-389397",
"REACTOME:R-CFA-416476",
"REACTOME:R-HSA-389397",
"REACTOME:R-HSA-416476",
"REACTOME:R-MMU-389397",
"REACTOME:R-MMU-416476",
"REACTOME:R-RNO-389397",
"REACTOME:R-RNO-416476",
"REACTOME:R-SSC-389397",
"REACTOME:R-SSC-416... | 12 | [
"1cq0",
"1r02",
"1wso",
"7l1u"
] | 4 | [
"PUB00000959",
"PUB00004918",
"PUB00004929",
"PUB00101334"
] | [
"9491897",
"9419374",
"9892705",
"9879756"
] | [
"Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.",
"The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.",
"Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuror... | [
1998,
1998,
1999,
1998
] | 4 | [] | [] | 0 | 0 | null | [
"Chordata"
] | [
744
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
3,
4
] | 4 | true | Family | Prepro-orexin | Prepro-orexin | Orexin | 1 |
IPR001705 | 1,705 | Large ribosomal subunit protein bL33 | Ribosomal_bL33 | Family | 42,912 | false | false | Ribosomal protein bL33 is one of the proteins from the large ribosomal subunit. In Escherichia coli, bL33 has been shown to be on the surface of 50S subunit. L33 belongs to a family of ribosomal proteins which, on the basis of sequence similarities [ , ], groups: Eubacterial bL33. Algal and plant chloroplast bL33c. Cya... | [
"GO:0003735",
"GO:0006412",
"GO:0005840"
] | [
"structural constituent of ribosome",
"translation",
"ribosome"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"HAMAP",
"PFAM",
"PANTHER",
"NCBIFAM"
] | [
"MF_00294",
"PF00471",
"PTHR43168",
"TIGR01023"
] | [
"Ribosomal_bL33",
"Ribosomal_L33",
"",
"rpmG_bact"
] | [
40649,
42673,
26242,
42814
] | 4 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC00503",
"R-BTA-5389840",
"R-BTA-5419276",
"R-BTA-9937383",
"R-HSA-5368286",
"R-HSA-5389840",
"R-HSA-5419276",
"R-HSA-9937383",
"R-MMU-5389840",
"R-MMU-5419276",
"R-MMU-9937383"
] | [
"PROSITEDOC:PDOC00503",
"REACTOME:R-BTA-5389840",
"REACTOME:R-BTA-5419276",
"REACTOME:R-BTA-9937383",
"REACTOME:R-HSA-5368286",
"REACTOME:R-HSA-5389840",
"REACTOME:R-HSA-5419276",
"REACTOME:R-HSA-9937383",
"REACTOME:R-MMU-5389840",
"REACTOME:R-MMU-5419276",
"REACTOME:R-MMU-9937383"
] | 11 | [
"1nkw",
"1nwx",
"1nwy",
"1sm1",
"1vvj",
"1vy4",
"1vy5",
"1vy6",
"1vy7",
"1xbp",
"2ftc",
"2j28",
"2rdo",
"2zjp",
"2zjq",
"2zjr",
"3bbx",
"3cf5",
"3dll",
"3iy9",
"3j5l",
"3j5s",
"3j6b",
"3j7y",
"3j7z",
"3j9m",
"3j9w",
"3j9y",
"3j9z",
"3ja1",
"3jbu",
"3jbv"... | 1,175 | [
"PUB00000695",
"PUB00001843",
"PUB00007068",
"PUB00007069",
"PUB00007070",
"PUB00162566"
] | [
"1742360",
"8112583",
"11297922",
"11290319",
"11114498",
"30306205"
] | [
"Characterization and primary structure of proteins L28, L33 and L34 from Bacillus stearothermophilus ribosomes.",
"Identification of genes encoding ribosomal protein L33 from Bacillus licheniformis, Thermus thermophilus and Thermotoga maritima.",
"Atomic structures at last: the ribosome in 2000.",
"The ribos... | [
1991,
1994,
2001,
2001,
2000,
2018
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Thermoproteota archaeon",
"unclassified sequences"
] | [
27138,
15453,
1,
320
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)... | [
7,
1,
1,
1,
2,
1,
4,
3,
1,
1,
4
] | 11 | true | Family | Large ribosomal subunit protein bL33 | Large ribosomal subunit protein bL33 | Ribosomal_bL33 | 7 |
IPR001706 | 1,706 | Large ribosomal subunit protein bL35 | Ribosomal_bL35 | Family | 24,484 | false | false | This entry represents the large ribosomal subunit protein bL35. Members of this family are predominantly found in bacteria and some plant and fungal species. This entry represents the large ribosomal subunit protein bL35, previously known as L35, a basic protein of 60 to 70 amino-acid residues [ ]. Like many basic poly... | [
"GO:0003735",
"GO:0006412",
"GO:0005840"
] | [
"structural constituent of ribosome",
"translation",
"ribosome"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"HAMAP",
"PRINTS",
"PANTHER",
"NCBIFAM"
] | [
"MF_00514",
"PR00064",
"PTHR33343",
"TIGR00001"
] | [
"Ribosomal_bL35",
"RIBOSOMALL35",
"",
"rpmI_bact"
] | [
23718,
24013,
23179,
23421
] | 4 | [
"PROSITEDOC"
] | [
"PDOC00721"
] | [
"PROSITEDOC:PDOC00721"
] | 1 | [
"1nkw",
"1nwx",
"1nwy",
"1sm1",
"1vvj",
"1vy4",
"1vy5",
"1vy6",
"1vy7",
"1xbp",
"2j28",
"2rdo",
"2zjp",
"2zjq",
"2zjr",
"3bbx",
"3cf5",
"3dll",
"3j5l",
"3j6b",
"3j7z",
"3j8g",
"3j9w",
"3j9y",
"3j9z",
"3ja1",
"3jbu",
"3jbv",
"3jcd",
"3jce",
"3jcj",
"3jcn"... | 1,094 | [
"PUB00000333",
"PUB00000584",
"PUB00007068",
"PUB00007069",
"PUB00007070"
] | [
"2271612",
"3542048",
"11297922",
"11290319",
"11114498"
] | [
"Ribosomal protein L35: identification in spinach chloroplasts and isolation of a cDNA clone encoding its cytoplasmic precursor.",
"Nonspecific inhibition of Escherichia coli ornithine decarboxylase by various ribosomal proteins: detection of a new ribosomal protein possessing strong antizyme activity.",
"Atomi... | [
1990,
1987,
2001,
2001,
2000
] | 5 | [
"IPR021137"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctjdk2",
"unclassified sequences"
] | [
22203,
1860,
1,
420
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
2,
1,
3,
1,
1,
14
] | 6 | true | Family | Large ribosomal subunit protein bL35 | Large ribosomal subunit protein bL35 | Ribosomal_bL35 | 8 |
IPR001707 | 1,707 | Chloramphenicol acetyltransferase | Cmp_AcTrfase | Family | 4,492 | false | false | Chloramphenicol acetyltransferase (CAT) ( ) [ ] catalyzes the acetyl-CoA dependent acetylation of chloramphenicol (Cm), an antibiotic which inhibits prokaryotic peptidyltransferase activity. Acetylation of Cm by CAT inactivates the antibiotic. A histidine residue, located in the C-terminal section of the enzyme, plays ... | [
"GO:0008811"
] | [
"chloramphenicol O-acetyltransferase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PIRSF",
"PANTHER",
"SMART"
] | [
"PF00302",
"PIRSF000440",
"PTHR38474",
"SM01059"
] | [
"CAT",
"CAT",
"",
"CAT"
] | [
4439,
2910,
4377,
4344
] | 4 | [
"EC",
"PROSITEDOC"
] | [
"2.3.1.28",
"PDOC00093"
] | [
"EC:2.3.1.28",
"PROSITEDOC:PDOC00093"
] | 2 | [
"1cia",
"1cla",
"1noc",
"1pd5",
"1q23",
"1qca",
"2cla",
"2i9d",
"3cla",
"3u9b",
"3u9f",
"4cla",
"6x7q",
"9m5s",
"9xc8"
] | 15 | [
"PUB00000094",
"PUB00006247"
] | [
"1867713",
"2187098"
] | [
"The zipper-like folding of collagen triple helices and the effects of mutations that disrupt the zipper.",
"Refined crystal structure of type III chloramphenicol acetyltransferase at 1.75 A resolution."
] | [
1991,
1990
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"Plasmid pSBK203",
"Viruses",
"unclassified sequences"
] | [
4351,
15,
61,
1,
10,
54
] | 6 | [] | [] | 0 | true | Family | Chloramphenicol acetyltransferase | Chloramphenicol acetyltransferase | Cmp_AcTrfase | 4 |
IPR001709 | 1,709 | Flavoprotein pyridine nucleotide cytochrome reductase | Flavoprot_Pyr_Nucl_cyt_Rdtase | Domain | 88,441 | false | false | Flavoprotein pyridine nucleotide cytochrome reductases [ ] (FPNCR) catalyse the interchange of reducing equivalents between one-electron carriers and the two-electron-carrying nicotinamide dinucleotides. The enzymes include ferredoxin:NADP + reductases (FNR) [ ], plant and fungal NAD(P)H:nitrate reductases [ , ], NADH:... | [
"GO:0016491"
] | [
"oxidoreductase activity"
] | [
"molecular_function"
] | 1 | [
"PRINTS"
] | [
"PR00371"
] | [
"FPNCR"
] | [
88441
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-114608",
"R-BTA-1237044",
"R-BTA-196836",
"R-BTA-211945",
"R-BTA-6798695",
"R-CEL-156581",
"R-CEL-1614635",
"R-CEL-9759218",
"R-CFA-196836",
"R-CFA-211945",
"R-CFA-6798695",
"R-DDI-114608",
"R-DDI-1222556",
"R-DDI-1474151",
"R-DDI-196836",
"R-DDI-203615",
"R-DDI-203754",
"R-... | [
"REACTOME:R-BTA-114608",
"REACTOME:R-BTA-1237044",
"REACTOME:R-BTA-196836",
"REACTOME:R-BTA-211945",
"REACTOME:R-BTA-6798695",
"REACTOME:R-CEL-156581",
"REACTOME:R-CEL-1614635",
"REACTOME:R-CEL-9759218",
"REACTOME:R-CFA-196836",
"REACTOME:R-CFA-211945",
"REACTOME:R-CFA-6798695",
"REACTOME:R-DD... | 127 | [
"1a8p",
"1amo",
"1b2r",
"1bjk",
"1bqe",
"1bx0",
"1bx1",
"1cne",
"1cnf",
"1ddg",
"1ddi",
"1e62",
"1e63",
"1e64",
"1ewy",
"1f20",
"1fnb",
"1fnc",
"1fnd",
"1frn",
"1frq",
"1gaq",
"1gaw",
"1gjr",
"1go2",
"1gr1",
"1h42",
"1h85",
"1i7p",
"1ib0",
"1j9z",
"1ja0"... | 184 | [
"PUB00001372",
"PUB00001683",
"PUB00002328",
"PUB00002370",
"PUB00002509",
"PUB00002674",
"PUB00003255",
"PUB00004098",
"PUB00005007",
"PUB00005135",
"PUB00005247",
"PUB00005356",
"PUB00005367"
] | [
"2924777",
"7890048",
"3700359",
"8027025",
"2550423",
"1748631",
"2319593",
"1712077",
"8298460",
"1986412",
"7812715",
"2204158",
"1908607"
] | [
"cDNA sequence of adrenodoxin reductase. Identification of NADP-binding sites in oxidoreductases.",
"Specific arrangement of three amino acid residues for flavin-binding barrel structures in NADH-cytochrome b5 reductase and the other flavin-dependent reductases.",
"Complete amino acid sequence of NADH-cytochrom... | [
1989,
1995,
1986,
1994,
1989,
1991,
1990,
1991,
1993,
1991,
1994,
1990,
1991
] | 13 | [
"IPR001433"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Vibrio phage VP-HS15",
"plasmids",
"unclassified sequences"
] | [
354,
47102,
40642,
1,
2,
340
] | 6 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
53,
6,
31,
19,
2,
37,
22,
10,
33,
43,
7,
6,
110
] | 13 | true | Domain | Flavoprotein pyridine nucleotide cytochrome reductase | Flavoprotein pyridine nucleotide cytochrome reductase | Flavoprot_Pyr_Nucl_cyt_Rdtase | 2 |
IPR001710 | 1,710 | Pro-adrenomedullin | Pro-ADM | Family | 728 | false | false | Pro-adrenomedullin (Pro-ADM) is a 185 amino acid long protein. It consists of a pro-ADM N-terminal 20 peptide (PAMP), a midregional pro-ADM (MR-proADM), an adrenotensin and a glycine-extended 53-amino acid peptides. The latter is subsequently converted to the mature ADM consisting of 52 amino acid by enzymatic amidatio... | [
"GO:0005179",
"GO:0005576"
] | [
"hormone activity",
"extracellular region"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR00801"
] | [
"ADRENOMEDULN"
] | [
728
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-418555",
"R-BTA-419812",
"R-BTA-9856530",
"R-HSA-418555",
"R-HSA-419812",
"R-HSA-9856530",
"R-MMU-418555",
"R-MMU-419812",
"R-MMU-9856530",
"R-RNO-419812",
"R-RNO-9856530",
"R-SSC-418555",
"R-SSC-419812",
"R-SSC-9856530"
] | [
"REACTOME:R-BTA-418555",
"REACTOME:R-BTA-419812",
"REACTOME:R-BTA-9856530",
"REACTOME:R-HSA-418555",
"REACTOME:R-HSA-419812",
"REACTOME:R-HSA-9856530",
"REACTOME:R-MMU-418555",
"REACTOME:R-MMU-419812",
"REACTOME:R-MMU-9856530",
"REACTOME:R-RNO-419812",
"REACTOME:R-RNO-9856530",
"REACTOME:R-SSC... | 14 | [
"2l7s",
"4rwf",
"6uun",
"6uus"
] | 4 | [
"PUB00094530",
"PUB00094531"
] | [
"29520277",
"31960799"
] | [
"Adrenomedullin and Adrenomedullin-Targeted Therapy As Treatment Strategies Relevant for Sepsis.",
"Adrenomedullin: an important participant in neurological diseases."
] | [
2018,
2020
] | 2 | [
"IPR021116"
] | [] | 1 | 0 | 1 | [
"Vertebrata"
] | [
728
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
5,
1,
4
] | 4 | true | Family | Pro-adrenomedullin | Pro-adrenomedullin | Pro-ADM | 7 |
IPR001712 | 1,712 | Type III secretion system FHIPEP | T3SS_FHIPEP | Family | 18,558 | false | false | The Flagellar/Hr/Invasion Proteins Export Pore (FHIPEP) family [ , ] consists of a number of proteins that constitute the type III secretion (or signal peptide-independent) pathway apparatus [ , ]. This mechanism translocates proteins lacking an N-terminal signal peptide across the cell membrane in one step, as it does... | [
"GO:0009306",
"GO:0016020"
] | [
"protein secretion",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PIRSF",
"PRINTS",
"PANTHER"
] | [
"PF00771",
"PIRSF005419",
"PR00949",
"PTHR30161"
] | [
"FHIPEP",
"FlhA",
"TYPE3IMAPROT",
""
] | [
18555,
16905,
17832,
18486
] | 4 | [
"PROSITEDOC"
] | [
"PDOC00763"
] | [
"PROSITEDOC:PDOC00763"
] | 1 | [
"2x49",
"2x4a",
"3a5i",
"3lw9",
"3mix",
"3myd",
"4a5p",
"6ai0",
"6ai1",
"6ai2",
"6ai3",
"6ch1",
"6ch2",
"6ch3",
"6wa6",
"6wa9",
"7alw",
"7amy",
"7awa",
"7ctn",
"7feb",
"7fec",
"7fed",
"7k08",
"7osl",
"7qij"
] | 26 | [
"PUB00002179",
"PUB00002235",
"PUB00002258",
"PUB00003759",
"PUB00005523",
"PUB00085104"
] | [
"1592799",
"8253684",
"8002587",
"8316211",
"1365398",
"18248436"
] | [
"Determinants of extracellular protein secretion in gram-negative bacteria.",
"HrpI of Erwinia amylovora functions in secretion of harpin and is a member of a new protein family.",
"Molecular characterization of the Salmonella typhimurium flhB operon and its protein products.",
"Homology between the HrpO prot... | [
1992,
1993,
1994,
1993,
1992,
2008
] | 6 | [] | [
"IPR006301",
"IPR006302"
] | 0 | 2 | 0 | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
18295,
46,
217
] | 3 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Type III secretion system FHIPEP | Type III secretion system FHIPEP | T3SS_FHIPEP | 9 |
IPR001713 | 1,713 | Proteinase inhibitor I25A, stefin | Prot_inh_stefin | Family | 2,941 | false | false | The cystatins are a superfamily of similar proteins present in mammals, birds, fish, insects, plants and protozoa. In general they are potent peptidase inhibitors [ , , , ] belonging to MEROPS inhibitor family I25, clan IH. The stefin family (MEROPS inhibitor family I25 clan IH, subfamily I25A) includes proteins that l... | [
"GO:0004866"
] | [
"endopeptidase inhibitor activity"
] | [
"molecular_function"
] | 1 | [
"PRINTS",
"PANTHER"
] | [
"PR00295",
"PTHR11414"
] | [
"STEFINA",
""
] | [
2607,
2899
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-6798695",
"R-HSA-6798695",
"R-HSA-6809371",
"R-MMU-6798695",
"R-MMU-6809371",
"R-RNO-6798695",
"R-SSC-6798695",
"R-SSC-6809371"
] | [
"REACTOME:R-DDI-6798695",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-6809371",
"REACTOME:R-MMU-6798695",
"REACTOME:R-MMU-6809371",
"REACTOME:R-RNO-6798695",
"REACTOME:R-SSC-6798695",
"REACTOME:R-SSC-6809371"
] | 8 | [
"1cyu",
"1cyv",
"1dvc",
"1dvd",
"1gd3",
"1gd4",
"1n9j",
"1nb3",
"1nb5",
"1stf",
"2oct",
"3k9m",
"3kfq",
"3kse",
"4n6v",
"5zc1",
"6qb2",
"8gqq",
"8gt0",
"8gt7",
"9uoz"
] | 21 | [
"PUB00001614",
"PUB00003345",
"PUB00003412",
"PUB00014312",
"PUB00015308"
] | [
"1855589",
"7869384",
"2107324",
"14587292",
"3555466"
] | [
"The cystatins: protein inhibitors of cysteine proteinases.",
"The three-dimensional solution structure of human stefin A.",
"Evolution of proteins of the cystatin superfamily.",
"Cystatins.",
"The cystatins: a diverse superfamily of cysteine peptidase inhibitors."
] | [
1991,
1995,
1990,
2003,
1986
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonas arcuscaelestis"
] | [
2940,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
6,
19,
20
] | 4 | true | Family | Proteinase inhibitor I25A, stefin | Proteinase inhibitor I25A, stefin | Prot_inh_stefin | 1 |
IPR001715 | 1,715 | Calponin homology domain | CH_dom | Domain | 169,165 | false | false | A number of actin-binding proteins, including spectrin, alpha-actinin and fimbrin, contain a 250 amino acid stretch called the actin binding domain (ABD). The ABD has probably arisen from duplication of a domain which is also found in a single copy in a number of other proteins like calponin or the vav proto-oncogene a... | [
"GO:0005515"
] | [
"protein binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF00307",
"PS50021",
"SM00033"
] | [
"CH",
"CH",
"CH"
] | [
144605,
167586,
129354
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC50021",
"R-BTA-114604",
"R-BTA-114608",
"R-BTA-1257604",
"R-BTA-141444",
"R-BTA-1433557",
"R-BTA-193648",
"R-BTA-2029482",
"R-BTA-2467813",
"R-BTA-2500257",
"R-BTA-2565942",
"R-BTA-2871796",
"R-BTA-2871809",
"R-BTA-380259",
"R-BTA-380270",
"R-BTA-380284",
"R-BTA-380320",
"R-BT... | [
"PROSITEDOC:PDOC50021",
"REACTOME:R-BTA-114604",
"REACTOME:R-BTA-114608",
"REACTOME:R-BTA-1257604",
"REACTOME:R-BTA-141444",
"REACTOME:R-BTA-1433557",
"REACTOME:R-BTA-193648",
"REACTOME:R-BTA-2029482",
"REACTOME:R-BTA-2467813",
"REACTOME:R-BTA-2500257",
"REACTOME:R-BTA-2565942",
"REACTOME:R-BT... | 401 | [
"1aa2",
"1aoa",
"1bhd",
"1bkr",
"1dxx",
"1h67",
"1mb8",
"1p2x",
"1p5s",
"1pa7",
"1pxy",
"1qag",
"1rt8",
"1sh5",
"1sh6",
"1sjj",
"1tjt",
"1ueg",
"1ujo",
"1v5k",
"1vka",
"1wix",
"1wjo",
"1wku",
"1wyl",
"1wym",
"1wyn",
"1wyo",
"1wyp",
"1wyq",
"1wyr",
"2d85"... | 140 | [
"PUB00001718",
"PUB00018082",
"PUB00024350",
"PUB00025538",
"PUB00029697",
"PUB00029793",
"PUB00031059",
"PUB00036320",
"PUB00042610",
"PUB00042611"
] | [
"9708889",
"9887274",
"10801490",
"11839310",
"15272162",
"12857735",
"15128297",
"9302997",
"17121810",
"17082327"
] | [
"CH domains revisited.",
"The 2.0 A structure of the second calponin homology domain from the actin-binding region of the dystrophin homologue utrophin.",
"The structure of the N-terminal actin-binding domain of human dystrophin and how mutations in this domain may cause Duchenne or Becker muscular dystrophy.",... | [
1998,
1999,
2000,
2002,
2004,
2003,
2004,
1997,
2007,
2007
] | 10 | [] | [
"IPR010441",
"IPR022613",
"IPR047290",
"IPR047291",
"IPR047826",
"IPR047827"
] | 0 | 6 | 0 | [
"Bacteria",
"Eukaryota",
"Fadolivirus FV1/VV64",
"bird metagenome"
] | [
9,
169152,
1,
3
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
84,
93,
1071,
148,
414,
325,
5,
26,
436,
5,
7,
183
] | 12 | true | Domain | Calponin homology domain | Calponin homology domain | CH_dom | 7 |
IPR001717 | 1,717 | Anion exchange protein | Anion_exchange | Family | 5,938 | false | false | Bicarbonate (HCO 3 - ) transport mechanisms are the principal regulators of pH in animal cells. Such transport also plays a vital role in acid-base movements in the stomach, pancreas, intestine, kidney, reproductive organs and the central nervous system. Functional studies have suggested four different HCO 3 - transpor... | [
"GO:0005452",
"GO:0006820",
"GO:0016020"
] | [
"solute:inorganic anion antiporter activity",
"monoatomic anion transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR00165"
] | [
"ANIONEXCHNGR"
] | [
5938
] | 1 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC00192",
"R-HSA-1237044",
"R-HSA-1247673",
"R-HSA-425381",
"R-HSA-5619050",
"R-MMU-1237044",
"R-MMU-1247673",
"R-MMU-425381",
"R-RNO-1237044",
"R-RNO-1247673",
"R-RNO-425381"
] | [
"PROSITEDOC:PDOC00192",
"REACTOME:R-HSA-1237044",
"REACTOME:R-HSA-1247673",
"REACTOME:R-HSA-425381",
"REACTOME:R-HSA-5619050",
"REACTOME:R-MMU-1237044",
"REACTOME:R-MMU-1247673",
"REACTOME:R-MMU-425381",
"REACTOME:R-RNO-1237044",
"REACTOME:R-RNO-1247673",
"REACTOME:R-RNO-425381"
] | 11 | [
"4yzf",
"7tvz",
"7tw0",
"7tw1",
"7tw2",
"7tw3",
"7tw5",
"7tw6",
"7ty4",
"7ty6",
"7ty7",
"7ty8",
"7tya",
"7uz3",
"7uzu",
"7uzv",
"7v07",
"7v0k",
"7v0m",
"7v0t",
"7v0u",
"7v0y",
"7v19",
"8crq",
"8crr",
"8crt",
"8cs9",
"8csl",
"8csv",
"8csy",
"8ct3",
"8cte"... | 55 | [
"PUB00005997",
"PUB00005998",
"PUB00005999",
"PUB00006000",
"PUB00006023",
"PUB00018713"
] | [
"2289848",
"2042971",
"9491367",
"10353704",
"9235899",
"9261985"
] | [
"Molecular biology of the anion exchanger gene family.",
"The band 3-related anion exchanger (AE) gene family.",
"The structure and function of band 3 (AE1): recent developments (review).",
"The association between familial distal renal tubular acidosis and mutations in the red cell anion exchanger (band 3, A... | [
1990,
1991,
1997,
1998,
1997,
1997
] | 6 | [
"IPR003020"
] | [
"IPR002977",
"IPR002978",
"IPR002979"
] | 1 | 3 | 0 | [
"Eukaryota",
"Lacipirellulaceae",
"bird metagenome"
] | [
5934,
3,
1
] | 3 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
33,
8,
21,
22,
17
] | 5 | true | Family | Anion exchange protein | Anion exchange protein | Anion_exchange | 1 |
IPR001718 | 1,718 | CC chemokine receptor 7 | Chemokine_CCR7 | Family | 748 | false | false | Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role [ ]. They have a wide rang... | [
"GO:0016493",
"GO:0006935",
"GO:0006954",
"GO:0006955",
"GO:0007186",
"GO:0016020"
] | [
"C-C chemokine receptor activity",
"chemotaxis",
"inflammatory response",
"immune response",
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"biological_process",
"biological_process",
"biological_process",
"cellular_component"
] | 6 | [
"PRINTS"
] | [
"PR00641"
] | [
"CHEMOKINER7"
] | [
748
] | 1 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"64",
"R-HSA-380108",
"R-HSA-418594",
"R-MMU-380108",
"R-MMU-418594"
] | [
"IUPHAR:64",
"REACTOME:R-HSA-380108",
"REACTOME:R-HSA-418594",
"REACTOME:R-MMU-380108",
"REACTOME:R-MMU-418594"
] | 5 | [
"6qzh"
] | 1 | [
"PUB00003502",
"PUB00009401",
"PUB00064589",
"PUB00064621",
"PUB00064622",
"PUB00064693",
"PUB00064695",
"PUB00064696",
"PUB00064697",
"PUB00064699",
"PUB00064700",
"PUB00064701",
"PUB00064702",
"PUB00064703",
"PUB00064974",
"PUB00067945",
"PUB00067946"
] | [
"8383238",
"11544102",
"10714678",
"10601351",
"9500790",
"9153236",
"11745346",
"16278415",
"15778365",
"15059845",
"12019175",
"12673677",
"12960129",
"17560334",
"10520991",
"9689100",
"7592998"
] | [
"Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors.",
"Chemokine receptors.",
"Chemokines: a new classification system and their role in immunity.",
"Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal langerhans cells."... | [
1993,
2001,
2000,
1999,
1998,
1997,
2001,
2005,
2005,
2004,
2002,
2003,
2003,
2007,
1999,
1998,
1995
] | 17 | [
"IPR000355"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
748
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
2,
3
] | 3 | true | Family | CC chemokine receptor 7 | CC chemokine receptor 7 | Chemokine_CCR7 | 5 |
IPR001719 | 1,719 | AP endonuclease 2 | AP_endonuc_2 | Family | 18,532 | false | false | AP endonucleases can be classified into two families based on sequence similarity. This family contains members of AP endonuclease family 2. Family 2 groups the enzymes listed below [ , ]. Bacterial endonuclease IV ( ). Mycobacterium leprae probable endonuclease [ ]. Saccharomyces cerevisiae (Baker's yeast) apurinic en... | [
"GO:0003677",
"GO:0008270",
"GO:0006281"
] | [
"DNA binding",
"zinc ion binding",
"DNA repair"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"HAMAP",
"PROFILE",
"PANTHER",
"SMART",
"NCBIFAM",
"CDD"
] | [
"MF_00152",
"PS51432",
"PTHR21445",
"SM00518",
"TIGR00587",
"cd00019"
] | [
"Nfo",
"AP_NUCLEASE_F2_4",
"",
"AP2Ec",
"nfo",
"AP2Ec"
] | [
12345,
15609,
16873,
16827,
13466,
15186
] | 6 | [
"EC",
"PROSITEDOC"
] | [
"3.1.21.2",
"PDOC00599"
] | [
"EC:3.1.21.2",
"PROSITEDOC:PDOC00599"
] | 2 | [
"1qtw",
"1qum",
"1xp3",
"2nq9",
"2nqh",
"2nqj",
"2x7v",
"2x7w",
"3aal",
"3aam",
"3ayt",
"3ayv",
"3wqo",
"4hno",
"4k1g",
"5zhz",
"6khy",
"6ki3",
"8axy",
"8edd",
"8pkb",
"8rly"
] | 22 | [
"PUB00000730",
"PUB00002671",
"PUB00003837",
"PUB00004710",
"PUB00017986",
"PUB00048372",
"PUB00052615"
] | [
"7661852",
"1720775",
"8446028",
"1693433",
"10458614",
"18408731",
"17242363"
] | [
"Structure and function of apurinic/apyrimidinic endonucleases.",
"Metalloenzymes in DNA repair. Escherichia coli endonuclease IV and Saccharomyces cerevisiae Apn1.",
"Nucleotide sequence of the first cosmid from the Mycobacterium leprae genome project: structure and function of the Rif-Str regions.",
"Yeast ... | [
1995,
1991,
1993,
1990,
1999,
2008,
2007
] | 7 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1185,
14364,
2425,
106,
452
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
5,
2,
1,
1,
1
] | 6 | true | Family | AP endonuclease 2 | AP endonuclease 2 | AP_endonuc_2 | 3 |
IPR001721 | 1,721 | Threonine dehydratase, ACT-like domain | TD_ACT-like | Domain | 16,930 | false | false | Threonine deaminase (threonine dehydratase, TD) is the first enzyme on the pathway for the biosynthesis of isoleucine. TD is organized into two domains. The larger N-terminal domain is considered the catalytic domain as it contains the essential pyridoxal phosphate cofactor. The C-terminal regulatory domain folds as an... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE"
] | [
"PF00585",
"PS51672"
] | [
"Thr_dehydrat_C",
"ACT_LIKE"
] | [
16886,
16723
] | 2 | [
"EC",
"METACYC"
] | [
"4.3.1.19",
"PWY-8443"
] | [
"EC:4.3.1.19",
"METACYC:PWY-8443"
] | 2 | [
"1tdj",
"8y1j",
"9d2q",
"9d2r",
"9d2s",
"9d2t"
] | 6 | [
"PUB00005304",
"PUB00005850",
"PUB00007206"
] | [
"9562556",
"10222208",
"11751050"
] | [
"Structure and control of pyridoxal phosphate dependent allosteric threonine deaminase.",
"Gleaning non-trivial structural, functional and evolutionary information about proteins by iterative database searches.",
"The ACT domain family."
] | [
1998,
1999,
2001
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Imitervirales",
"Methanofollis liminatans",
"unclassified sequences"
] | [
13691,
3122,
5,
1,
111
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
3,
1,
2,
5,
1,
1,
12
] | 7 | true | Domain | Threonine dehydratase, ACT-like domain | Threonine dehydratase, ACT-like domain | TD_ACT-like | 7 |
IPR001722 | 1,722 | Glycoside hydrolase, family 7 | Glyco_hydro_7 | Family | 10,183 | false | false | O-Glycosyl hydrolases ( ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ ,... | [
"GO:0004553",
"GO:0005975"
] | [
"hydrolase activity, hydrolyzing O-glycosyl compounds",
"carbohydrate metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PRINTS",
"PANTHER",
"CDD"
] | [
"PF00840",
"PR00734",
"PTHR33753",
"cd07999"
] | [
"Glyco_hydro_7",
"GLHYDRLASE7",
"",
"GH7_CBH_EG"
] | [
10135,
9826,
10136,
4288
] | 4 | [
"CAZY",
"EC",
"METACYC"
] | [
"GH7",
"3.2.1.91",
"PWY-6788"
] | [
"CAZY:GH7",
"EC:3.2.1.91",
"METACYC:PWY-6788"
] | 3 | [
"1a39",
"1cel",
"1dy4",
"1dym",
"1eg1",
"1egn",
"1gpi",
"1h46",
"1oji",
"1ojj",
"1ojk",
"1ovw",
"1q2b",
"1q2e",
"1q9h",
"1z3t",
"1z3v",
"1z3w",
"2a39",
"2cel",
"2ovw",
"2rfw",
"2rfy",
"2rfz",
"2rg0",
"2v3i",
"2v3r",
"2xsp",
"2y9n",
"2yg1",
"2yok",
"3cel"... | 95 | [
"PUB00003608",
"PUB00004870",
"PUB00005266"
] | [
"1886523",
"7624375",
"8535779"
] | [
"Domains in microbial beta-1, 4-glycanases: sequence conservation, function, and enzyme families.",
"Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.",
"Structures and mechanisms of glycosyl hydrolases."
] | [
1991,
1995,
1995
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"viral metagenome"
] | [
10182,
1
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
6
] | 1 | true | Family | Glycoside hydrolase, family 7 | Glycoside hydrolase, family 7 | Glyco_hydro_7 | 4 |
IPR001723 | 1,723 | Nuclear hormone receptor | Nuclear_hrmn_rcpt | Family | 81,307 | false | false | Steroid or nuclear hormone receptors (NRs) constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions, including control of embryonic development, cell differentiation and homeostasis. Members of the superfamily include the steroid hormone receptors and r... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR00398"
] | [
"STRDHORMONER"
] | [
81307
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1251985",
"R-BTA-1257604",
"R-BTA-381340",
"R-BTA-383280",
"R-BTA-4090294",
"R-BTA-5362517",
"R-BTA-5689896",
"R-BTA-6811558",
"R-BTA-8866427",
"R-BTA-8866910",
"R-BTA-8931987",
"R-BTA-8939211",
"R-BTA-9009391",
"R-BTA-9018519",
"R-BTA-9029569",
"R-BTA-9623433",
"R-BTA-9841251... | [
"REACTOME:R-BTA-1251985",
"REACTOME:R-BTA-1257604",
"REACTOME:R-BTA-381340",
"REACTOME:R-BTA-383280",
"REACTOME:R-BTA-4090294",
"REACTOME:R-BTA-5362517",
"REACTOME:R-BTA-5689896",
"REACTOME:R-BTA-6811558",
"REACTOME:R-BTA-8866427",
"REACTOME:R-BTA-8866910",
"REACTOME:R-BTA-8931987",
"REACTOME:... | 205 | [
"1a28",
"1a52",
"1bsx",
"1db1",
"1dkf",
"1e3g",
"1e3k",
"1ere",
"1err",
"1exa",
"1exx",
"1fby",
"1fcx",
"1fcy",
"1fcz",
"1fd0",
"1fm6",
"1fm9",
"1g1u",
"1g2n",
"1g50",
"1g5y",
"1gs4",
"1gwq",
"1gwr",
"1gwx",
"1h9u",
"1hg4",
"1hj1",
"1i37",
"1i38",
"1i7g"... | 1,984 | [
"PUB00004464",
"PUB00006168",
"PUB00015853"
] | [
"7899080",
"8165128",
"14747695"
] | [
"Vitamin D receptor contains multiple dimerization interfaces that are functionally different.",
"Human androgen receptor expressed in HeLa cells activates transcription in vitro.",
"Nuclear receptors: the evolution of diversity."
] | [
1995,
1994,
2004
] | 3 | [] | [
"IPR000003",
"IPR000128",
"IPR000324",
"IPR001409",
"IPR001728",
"IPR003069",
"IPR003070",
"IPR003074",
"IPR003078",
"IPR003079",
"IPR016355",
"IPR023257",
"IPR024178",
"IPR033544"
] | 0 | 14 | 0 | [
"Avian erythroblastosis virus",
"Eukaryota",
"unclassified sequences"
] | [
4,
81301,
2
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
70,
338,
52,
292,
169,
249
] | 6 | true | Family | Nuclear hormone receptor | Nuclear hormone receptor | Nuclear_hrmn_rcpt | 4 |
IPR001724 | 1,724 | Glycosyl hydrolase 58 | Glycl_Hydrolase_58 | Family | 59 | false | false | O-Glycosyl hydrolases ( ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ ,... | [
"GO:0016996"
] | [
"endo-alpha-(2,8)-sialidase activity"
] | [
"molecular_function"
] | 1 | [
"PRINTS"
] | [
"PR00849"
] | [
"GLHYDRLASE58"
] | [
59
] | 1 | [
"CAZY"
] | [
"GH58"
] | [
"CAZY:GH58"
] | 1 | [
"1v0e",
"1v0f",
"3gvj",
"3gvk",
"3gvl",
"3gw6",
"3ju4",
"4hiz"
] | 8 | [
"PUB00000538",
"PUB00002222",
"PUB00004870",
"PUB00005266",
"PUB00037909",
"PUB00082574"
] | [
"7626018",
"8331067",
"7624375",
"8535779",
"15608653",
"20096705"
] | [
"Complete nucleotide sequence of the gene encoding bacteriophage E endosialidase: implications for K1E endosialidase structure and function.",
"Complete nucleotide sequence of the bacteriophage K1F tail gene encoding endo-N-acylneuraminidase (endo-N) and comparison to an endo-N homolog in bacteriophage PK1E.",
... | [
1995,
1993,
1995,
1995,
2005,
2010
] | 6 | [] | [] | 0 | 0 | null | [
"Gammaproteobacteria",
"Viruses"
] | [
20,
39
] | 2 | [] | [] | 0 | true | Family | Glycosyl hydrolase 58 | Glycosyl hydrolase 58 | Glycl_Hydrolase_58 | 7 |
IPR001726 | 1,726 | DNA nucleotidylexotransferase (TdT) / DNA-directed DNA/RNA polymerase mu | TdT/Mu | Family | 2,437 | false | false | DNA carries the biological information that instructs cells how to exist in an ordered fashion: accurate replication is thus one of the most important events in the cell life cycle. This function is mediated by DNA-directed DNA-polymerases, which add nucleotide triphosphate (dNTP) residues to the 5'-end of the growing ... | [
"GO:0034061"
] | [
"DNA polymerase activity"
] | [
"molecular_function"
] | 1 | [
"PIRSF",
"PRINTS"
] | [
"PIRSF000817",
"PR00871"
] | [
"DNA_NT",
"DNAPOLXTDT"
] | [
2202,
2054
] | 2 | [
"EC",
"REACTOME",
"REACTOME"
] | [
"2.7.7.31",
"R-HSA-5693571",
"R-MMU-5693571"
] | [
"EC:2.7.7.31",
"REACTOME:R-HSA-5693571",
"REACTOME:R-MMU-5693571"
] | 3 | [
"1jms",
"1kdh",
"1kej",
"2coe",
"2dun",
"2htf",
"2ihm",
"4i27",
"4i28",
"4i29",
"4i2a",
"4i2b",
"4i2c",
"4i2d",
"4i2e",
"4i2f",
"4i2g",
"4i2h",
"4i2i",
"4i2j",
"4iqt",
"4iqu",
"4iqv",
"4iqw",
"4lzd",
"4lzg",
"4m04",
"4m0a",
"4qz8",
"4qz9",
"4qza",
"4qzb"... | 168 | [
"PUB00004647",
"PUB00004955",
"PUB00063546",
"PUB00063547"
] | [
"3479792",
"2196557",
"12640116",
"17483519"
] | [
"Bacteriophage PRD1 DNA polymerase: evolution of DNA polymerases.",
"An attempt to unify the structure of polymerases.",
"Polymerase mu is a DNA-directed DNA/RNA polymerase.",
"Involvement of DNA polymerase mu in the repair of a specific subset of DNA double-strand breaks in mammalian cells."
] | [
1987,
1990,
2003,
2007
] | 4 | [
"IPR022312"
] | [
"IPR027249",
"IPR027292"
] | 1 | 2 | 0 | [
"Eukaryota"
] | [
2437
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
10,
10,
6,
7
] | 4 | true | Family | DNA nucleotidylexotransferase (TdT) / DNA-directed DNA/RNA polymerase mu | DNA nucleotidylexotransferase (TdT) / DNA-directed DNA/RNA polymerase mu | TdT/Mu | 8 |
IPR001727 | 1,727 | GDT1-like | GDT1-like | Family | 16,155 | false | false | Budding yeast GDT1 is a Golgi-localized calcium transporter required for stress-induced calcium signalling and protein glycosylation [ ]. Its human homologue, TMEM165, also a Golgi protein, transports Ca2+ and Mn2+, which are both required for proper protein glycosylation in cells [ , ]. Defects in the human protein TM... | [
"GO:0046873"
] | [
"metal ion transmembrane transporter activity"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF01169",
"PTHR12608"
] | [
"GDT1",
""
] | [
16108,
15651
] | 2 | [
"PROSITEDOC"
] | [
"PDOC00934"
] | [
"PROSITEDOC:PDOC00934"
] | 1 | [] | 0 | [
"PUB00079030",
"PUB00079031",
"PUB00079032",
"PUB00083225",
"PUB00083226",
"PUB00152812"
] | [
"27075443",
"24530912",
"23569283",
"27302341",
"27020959",
"32047108"
] | [
"Yeast Gdt1 is a Golgi-localized calcium transporter required for stress-induced calcium signaling and protein glycosylation.",
"The Ca(2+)/H(+) antiporter TMEM165 expression, localization in the developing, lactating and involuting mammary gland parallels the secretory pathway Ca(2+) ATPase (SPCA1).",
"Newly c... | [
2016,
2014,
2013,
2016,
2016,
2020
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
355,
8204,
7491,
105
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
21,
2,
1,
4,
5,
3,
1,
7,
2,
1,
2,
45
] | 12 | true | Family | GDT1-like | GDT1-like | GDT1-like | 6 |
IPR001728 | 1,728 | Thyroid hormone receptor | ThyrH_rcpt | Family | 9,579 | false | false | Steroid or nuclear hormone receptors (NRs) constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions, including control of embryonic development, cell differentiation and homeostasis. Members of the superfamily include the steroid hormone receptors and r... | [
"GO:0003677",
"GO:0004879",
"GO:0006355"
] | [
"DNA binding",
"nuclear receptor activity",
"regulation of DNA-templated transcription"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PRINTS"
] | [
"PR00546"
] | [
"THYROIDHORMR"
] | [
9579
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-200425",
"R-DME-381340",
"R-DME-383280",
"R-DME-400206",
"R-DME-4090294",
"R-DME-5362517",
"R-DME-9616222",
"R-DME-9707564",
"R-DME-9841922",
"R-GGA-383280",
"R-GGA-4090294",
"R-HSA-159418",
"R-HSA-192105",
"R-HSA-193368",
"R-HSA-193807",
"R-HSA-1989781",
"R-HSA-211976",
"R-... | [
"REACTOME:R-DME-200425",
"REACTOME:R-DME-381340",
"REACTOME:R-DME-383280",
"REACTOME:R-DME-400206",
"REACTOME:R-DME-4090294",
"REACTOME:R-DME-5362517",
"REACTOME:R-DME-9616222",
"REACTOME:R-DME-9707564",
"REACTOME:R-DME-9841922",
"REACTOME:R-GGA-383280",
"REACTOME:R-GGA-4090294",
"REACTOME:R-H... | 35 | [
"1bsx",
"1db1",
"1ie8",
"1ie9",
"1ilg",
"1ilh",
"1m13",
"1n46",
"1nav",
"1nax",
"1nde",
"1nq0",
"1nq1",
"1nq2",
"1nrl",
"1nuo",
"1osh",
"1osv",
"1ot7",
"1q4x",
"1qkm",
"1r6g",
"1rjk",
"1rk3",
"1rkg",
"1rkh",
"1s0z",
"1s19",
"1skx",
"1txi",
"1u3q",
"1u3r"... | 378 | [
"PUB00004221",
"PUB00004225",
"PUB00004464",
"PUB00006168",
"PUB00015853"
] | [
"7566127",
"7501015",
"7899080",
"8165128",
"14747695"
] | [
"A transcriptional co-repressor that interacts with nuclear hormone receptors.",
"A structural role for hormone in the thyroid hormone receptor.",
"Vitamin D receptor contains multiple dimerization interfaces that are functionally different.",
"Human androgen receptor expressed in HeLa cells activates transcr... | [
1995,
1995,
1995,
1994,
2004
] | 5 | [
"IPR001723"
] | [] | 1 | 0 | 1 | [
"Avian erythroblastosis virus",
"Metazoa"
] | [
4,
9575
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
60,
15,
30,
15,
26
] | 5 | true | Family | Thyroid hormone receptor | Thyroid hormone receptor | ThyrH_rcpt | 5 |
IPR001729 | 1,729 | Pulmonary surfactant-associated protein C | SP-C | Family | 934 | false | false | Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-C, a component of surfactant, is a highly hydrophobic peptide of 35 amino acid residues which is processed from a larger precursor protein. SP-C is post-transl... | [
"GO:0007585",
"GO:0005576"
] | [
"respiratory gaseous exchange by respiratory system",
"extracellular region"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PANTHER",
"SMART"
] | [
"PTHR10800",
"SM00019"
] | [
"",
"SF_P"
] | [
899,
797
] | 2 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC00298",
"R-HSA-5683826",
"R-HSA-5688354",
"R-HSA-5688849",
"R-HSA-5688890",
"R-MMU-5683826",
"R-RNO-5683826"
] | [
"PROSITEDOC:PDOC00298",
"REACTOME:R-HSA-5683826",
"REACTOME:R-HSA-5688354",
"REACTOME:R-HSA-5688849",
"REACTOME:R-HSA-5688890",
"REACTOME:R-MMU-5683826",
"REACTOME:R-RNO-5683826"
] | 7 | [
"2yad",
"8ovi",
"8ox2"
] | 3 | [
"PUB00001605",
"PUB00004706"
] | [
"2015882",
"2326260"
] | [
"Canine hydrophobic surfactant polypeptide SP-C. A lipopeptide with one thioester-linked palmitoyl group.",
"Hydrophobic surfactant-associated polypeptides: SP-C is a lipopeptide with two palmitoylated cysteine residues, whereas SP-B lacks covalently linked fatty acyl groups."
] | [
1991,
1990
] | 2 | [] | [] | 0 | 0 | null | [
"Eumetazoa",
"bird metagenome"
] | [
932,
2
] | 2 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
2,
4
] | 3 | true | Family | Pulmonary surfactant-associated protein C | Pulmonary surfactant-associated protein C | SP-C | 7 |
IPR001730 | 1,730 | Potyvirus NIa protease (NIa-pro) domain | Potyv_NIa-pro_dom | Domain | 5,131 | false | false | Tobacco etch virus (TEV), tomato vein mottling virus (TVMV), and plum pox virus (PPV) are members of the Potyviridae family. The potyvirus genome is a (+) stranded RNA and is translated into a single polyprotein upon infection, which is processed by the virally encoded proteases P1, HC-Pro, and NIa. Most of the cleavag... | [
"GO:0008234",
"GO:0006508"
] | [
"cysteine-type peptidase activity",
"proteolysis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PRINTS",
"PROFILE"
] | [
"PF00863",
"PR00966",
"PS51436"
] | [
"Peptidase_C4",
"NIAPOTYPTASE",
"POTYVIRUS_NIA_PRO"
] | [
4590,
5054,
4588
] | 3 | [
"EC",
"EC",
"EC",
"EC",
"EC",
"METACYC",
"METACYC"
] | [
"2.7.7.48",
"3.4.21.-",
"3.4.22.44",
"3.4.22.45",
"3.6.4.-",
"PWY-7250",
"PWY-7884"
] | [
"EC:2.7.7.48",
"EC:3.4.21.-",
"EC:3.4.22.44",
"EC:3.4.22.45",
"EC:3.6.4.-",
"METACYC:PWY-7250",
"METACYC:PWY-7884"
] | 7 | [
"1lvb",
"1lvm",
"1q31",
"3mmg",
"6nfw",
"6suq",
"9n7y"
] | 7 | [
"PUB00011704",
"PUB00020025",
"PUB00022120",
"PUB00030423",
"PUB00057996",
"PUB00057997",
"PUB00076953"
] | [
"11517925",
"9891971",
"12377789",
"14725770",
"18024078",
"9356344",
"7044372"
] | [
"Evolutionary lines of cysteine peptidases.",
"Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases.",
"Structural basis for the substrate specificity of tobacco etch virus protease.",
"The structure of sortase B, a cysteine tr... | [
2001,
1998,
2002,
2004,
2008,
1997,
1982
] | 7 | [] | [] | 0 | 0 | null | [
"Opisthokonta",
"Orthornavirae",
"Streptococcus pneumoniae"
] | [
2,
5128,
1
] | 3 | [] | [] | 0 | true | Domain | Potyvirus NIa protease (NIa-pro) domain | Potyvirus NIa protease (NIa-pro) domain | Potyv_NIa-pro_dom | 3 |
IPR001731 | 1,731 | Delta-aminolevulinic acid dehydratase | ALAD | Family | 28,021 | false | false | Tetrapyrroles are large macrocyclic compounds derived from a common biosynthetic pathway [ ]. The end-product, uroporphyrinogen III, is used to synthesise a number of important molecules, including vitamin B12, haem, sirohaem, chlorophyll, coenzyme F430 and phytochromobilin [ ]. The first stage in tetrapyrrole synthesi... | [
"GO:0004655",
"GO:0046872",
"GO:0033014"
] | [
"porphobilinogen synthase activity",
"metal ion binding",
"tetrapyrrole biosynthetic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"NCBIFAM",
"PFAM",
"PIRSF",
"PRINTS",
"PANTHER",
"SMART"
] | [
"NF006762",
"PF00490",
"PIRSF001415",
"PR00144",
"PTHR11458",
"SM01004"
] | [
"PRK09283.1",
"ALAD",
"Porphbilin_synth",
"DALDHYDRTASE",
"",
"ALAD"
] | [
26272,
27994,
25187,
27253,
27819,
27835
] | 6 | [
"EC",
"GP",
"GP",
"GP",
"METACYC",
"METACYC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"4.2.1.24",
"GenProp0220",
"GenProp1525",
"GenProp1701",
"PWY-5188",
"PWY-5189",
"PDOC00153",
"R-BTA-189451",
"R-BTA-6798695",
"R-DDI-189451",
"R-DDI-6798695",
"R-HSA-189451",
"R-HSA-6798695",
"R-MMU-189451",
"R-MMU-6798695",
"R-RNO-189451",
"R-RNO-6798695",
"R-SCE-189451",
"R-SC... | [
"EC:4.2.1.24",
"GP:GenProp0220",
"GP:GenProp1525",
"GP:GenProp1701",
"METACYC:PWY-5188",
"METACYC:PWY-5189",
"PROSITEDOC:PDOC00153",
"REACTOME:R-BTA-189451",
"REACTOME:R-BTA-6798695",
"REACTOME:R-DDI-189451",
"REACTOME:R-DDI-6798695",
"REACTOME:R-HSA-189451",
"REACTOME:R-HSA-6798695",
"REA... | 21 | [
"1aw5",
"1b4e",
"1b4k",
"1e51",
"1eb3",
"1gjp",
"1gzg",
"1h7n",
"1h7o",
"1h7p",
"1h7r",
"1i8j",
"1l6s",
"1l6y",
"1ohl",
"1pv8",
"1qml",
"1qnv",
"1w1z",
"1w31",
"1w54",
"1w56",
"1w5m",
"1w5n",
"1w5o",
"1w5p",
"1w5q",
"1ylv",
"2c13",
"2c14",
"2c15",
"2c16"... | 43 | [
"PUB00000460",
"PUB00009744",
"PUB00035496",
"PUB00035498",
"PUB00035500",
"PUB00035501"
] | [
"3092810",
"11215515",
"17227226",
"16564539",
"17311232",
"17236137"
] | [
"Identification of lysine at the active site of human 5-aminolaevulinate dehydratase.",
"Biosynthesis of cobalamin (vitamin B12): a bacterial conundrum.",
"Tetrapyrrole biosynthesis in higher plants.",
"Evolutionary relationship between initial enzymes of tetrapyrrole biosynthesis.",
"Synthesis of bisubstra... | [
1986,
2000,
2007,
2006,
2007,
2007
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
779,
21774,
5097,
371
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae... | [
6,
1,
1,
1,
5,
4,
1,
1,
5,
1,
1,
6
] | 12 | true | Family | Delta-aminolevulinic acid dehydratase | Delta-aminolevulinic acid dehydratase | ALAD | 1 |
IPR001732 | 1,732 | UDP-glucose/GDP-mannose dehydrogenase, N-terminal | UDP-Glc/GDP-Man_DH_N | Domain | 61,750 | false | false | This entry represents the N-terminal NAD(+)-binding domain. Structural studies indicate that this domain forms an α-β structure containing the six-stranded parallel β sheet characteristic of the dinucleotide binding Rossman fold [ , ]. The UDP-glucose/GDP-mannose dehydrogenases are a small group of enzymes which posses... | [
"GO:0016616",
"GO:0051287"
] | [
"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor",
"NAD binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM"
] | [
"PF03721"
] | [
"UDPG_MGDP_dh_N"
] | [
61750
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.1.1",
"1.1.1.22",
"PWY-7346",
"PWY-7820",
"R-BTA-173599",
"R-CEL-173599",
"R-DME-173599",
"R-GGA-173599",
"R-HSA-173599",
"R-MMU-173599",
"R-RNO-173599"
] | [
"EC:1.1.1",
"EC:1.1.1.22",
"METACYC:PWY-7346",
"METACYC:PWY-7820",
"REACTOME:R-BTA-173599",
"REACTOME:R-CEL-173599",
"REACTOME:R-DME-173599",
"REACTOME:R-GGA-173599",
"REACTOME:R-HSA-173599",
"REACTOME:R-MMU-173599",
"REACTOME:R-RNO-173599"
] | 11 | [
"1dli",
"1dlj",
"1mfz",
"1muu",
"1mv8",
"2o3j",
"2q3e",
"2qg4",
"2y0c",
"2y0d",
"2y0e",
"3g79",
"3gg2",
"3itk",
"3khu",
"3ojl",
"3ojo",
"3phl",
"3pid",
"3pjg",
"3pln",
"3plr",
"3prj",
"3ptz",
"3tdk",
"3tf5",
"3vtf",
"4a7p",
"4edf",
"4r16",
"4rjt",
"4xr9"... | 45 | [
"PUB00002546",
"PUB00003005",
"PUB00009417",
"PUB00009418",
"PUB00009419",
"PUB00009420",
"PUB00009421",
"PUB00027324",
"PUB00028366"
] | [
"2470755",
"9013585",
"12031484",
"11533493",
"11554764",
"12135385",
"9864323",
"12705829",
"10841783"
] | [
"Purification and characterization of guanosine diphospho-D-mannose dehydrogenase. A key enzyme in the biosynthesis of alginate by Pseudomonas aeruginosa.",
"Properties and kinetic analysis of UDP-glucose dehydrogenase from group A streptococci. Irreversible inhibition by UDP-chloroacetol.",
"Molecular cloning ... | [
1989,
1997,
2002,
2001,
2001,
2002,
1999,
2003,
2000
] | 9 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1832,
51152,
7492,
51,
1223
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
8,
1,
1,
1,
2,
9,
7,
2,
12,
3,
8
] | 11 | true | Domain | UDP-glucose/GDP-mannose dehydrogenase, N-terminal | UDP-glucose/GDP-mannose dehydrogenase, N-terminal | UDP-Glc/GDP-Man_DH_N | 4 |
IPR001733 | 1,733 | Peptidase S26B | Peptidase_S26B | Family | 13,002 | false | false | Proteolytic enzymes that exploit serine in their catalytic activity are ubiquitous, being found in viruses, bacteria and eukaryotes [ ]. They include a wide range of peptidase activity, including exopeptidase, endopeptidase, oligopeptidase and omega-peptidase activity. Many families of serine protease have been identif... | [
"GO:0008233",
"GO:0006465",
"GO:0016020"
] | [
"peptidase activity",
"signal peptide processing",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS",
"PANTHER",
"NCBIFAM"
] | [
"PR00728",
"PTHR10806",
"TIGR02228"
] | [
"SIGNALPTASE",
"",
"sigpep_I_arch"
] | [
8022,
11053,
11660
] | 3 | [
"EC",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.4.21.89",
"GenProp0957",
"R-BTA-422085",
"R-BTA-9768727",
"R-CFA-422085",
"R-CFA-9768727",
"R-HSA-1799339",
"R-HSA-381771",
"R-HSA-400511",
"R-HSA-422085",
"R-HSA-9768727",
"R-HSA-9828806",
"R-MMU-422085",
"R-MMU-9768727",
"R-RNO-422085",
"R-RNO-9768727"
] | [
"EC:3.4.21.89",
"GP:GenProp0957",
"REACTOME:R-BTA-422085",
"REACTOME:R-BTA-9768727",
"REACTOME:R-CFA-422085",
"REACTOME:R-CFA-9768727",
"REACTOME:R-HSA-1799339",
"REACTOME:R-HSA-381771",
"REACTOME:R-HSA-400511",
"REACTOME:R-HSA-422085",
"REACTOME:R-HSA-9768727",
"REACTOME:R-HSA-9828806",
"RE... | 16 | [
"7p2p",
"7p2q"
] | 2 | [
"PUB00000522",
"PUB00003576"
] | [
"8439290",
"7845208"
] | [
"Evolutionary families of peptidases.",
"Families of serine peptidases."
] | [
1993,
1994
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Pandoravirus",
"metagenomes"
] | [
1851,
4168,
6840,
8,
135
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
7,
1,
1,
2,
12,
10,
1,
10,
16,
1,
1,
18
] | 12 | true | Family | Peptidase S26B | Peptidase S26B | Peptidase_S26B | 8 |
IPR001734 | 1,734 | Sodium/solute symporter | Na/solute_symporter | Family | 124,179 | false | false | Sodium/substrate symport (or co-transport) is a widespread mechanism of solute transport across cytoplasmic membranes of pro-and eukaryotic cells. Thereby the energy stored in an inwardly directed electrochemical sodium gradient (sodium motive force, SMF) is used to drive solute accumulation against a concentration gra... | [
"GO:0022857",
"GO:0055085",
"GO:0016020"
] | [
"transmembrane transporter activity",
"transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PROFILE",
"NCBIFAM"
] | [
"PF00474",
"PS50283",
"TIGR00813"
] | [
"SSF",
"NA_SOLUT_SYMP_3",
"sss"
] | [
111409,
123901,
56806
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00429",
"R-BTA-189200",
"R-BTA-427601",
"R-CEL-264642",
"R-CEL-425366",
"R-CFA-429593",
"R-DME-209968",
"R-DME-264642",
"R-DME-425366",
"R-DME-427601",
"R-DME-428643",
"R-DRE-189200",
"R-DRE-196807",
"R-DRE-427601",
"R-DRE-428643",
"R-HSA-189200",
"R-HSA-196780",
"R-HSA-196807... | [
"PROSITEDOC:PDOC00429",
"REACTOME:R-BTA-189200",
"REACTOME:R-BTA-427601",
"REACTOME:R-CEL-264642",
"REACTOME:R-CEL-425366",
"REACTOME:R-CFA-429593",
"REACTOME:R-DME-209968",
"REACTOME:R-DME-264642",
"REACTOME:R-DME-425366",
"REACTOME:R-DME-427601",
"REACTOME:R-DME-428643",
"REACTOME:R-DRE-1892... | 56 | [
"2xq2",
"3dh4",
"5nv9",
"5nva",
"7sl8",
"7sl9",
"7sla",
"7uuy",
"7uuz",
"7uv0",
"7vsi",
"7wmv",
"7yni",
"7ynj",
"7ynk",
"8hb0",
"8hdh",
"8hez",
"8hg7",
"8hin",
"8j74",
"8j75",
"8j76",
"8j77",
"8zqo",
"8zqp",
"8zqq",
"8zqr",
"9bfi",
"9bfj",
"9bfk",
"9bim"... | 40 | [
"PUB00000660",
"PUB00005080",
"PUB00009984"
] | [
"8031825",
"1965458",
"12354616"
] | [
"A functional superfamily of sodium/solute symporters.",
"The Na+/pantothenate symporter (PanF) of Escherichia coli is homologous to the Na+/proline symporter (PutP) of E. coli and the Na+/glucose symporters of mammals.",
"The sodium/substrate symporter family: structural and functional features."
] | [
1994,
1990,
2002
] | 3 | [] | [
"IPR011849",
"IPR011851",
"IPR014083",
"IPR019899",
"IPR031155",
"IPR035689",
"IPR042731"
] | 0 | 7 | 0 | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
2179,
84729,
11,
35754,
1506
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
2,
5,
37,
38,
4,
44,
49,
3,
1,
58,
1,
3,
2
] | 13 | true | Family | Sodium/solute symporter | Sodium/solute symporter | Na/solute_symporter | 2 |
IPR001735 | 1,735 | Opsin RH1/RH2 | Opsin_RH1/RH2 | Family | 419 | false | false | By contrast with vertebrate rhodopsin, which is found in rod cells, insect photoreceptors are found in the ommatidia that comprise the compound eyes. Each Drosophila eye has 800 ommatidia, each of which contains 8 photoreceptor cells (designated R1-R8): R1-R6 are outer cells, while R7 and R8 are inner cells. Opsins RH1... | [
"GO:0007186",
"GO:0007602",
"GO:0016020"
] | [
"G protein-coupled receptor signaling pathway",
"phototransduction",
"membrane"
] | [
"biological_process",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR00576"
] | [
"OPSINRH1RH2"
] | [
419
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-DME-416476",
"R-DME-419771"
] | [
"REACTOME:R-DME-416476",
"REACTOME:R-DME-419771"
] | 2 | [] | 0 | [
"PUB00000800",
"PUB00000801",
"PUB00000807"
] | [
"2985266",
"2580638",
"2936466"
] | [
"The Drosophila ninaE gene encodes an opsin.",
"Isolation and structure of a rhodopsin gene from D. melanogaster.",
"An opsin gene expressed in only one photoreceptor cell type of the Drosophila eye."
] | [
1985,
1985,
1986
] | 3 | [
"IPR001760"
] | [] | 1 | 0 | 1 | [
"Arthropoda"
] | [
419
] | 1 | [
"Drosophila melanogaster"
] | [
5
] | 1 | true | Family | Opsin RH1/RH2 | Opsin RH1/RH2 | Opsin_RH1/RH2 | 5 |
IPR001736 | 1,736 | Phospholipase D/Transphosphatidylase | PLipase_D/transphosphatidylase | Domain | 93,356 | false | false | Phosphatidylcholine-hydrolysing phospholipase D (PLD) isoforms are activated by ADP-ribosylation factors (ARFs). PLD produces phosphatidic acid from phosphatidylcholine, which may be essential for the formation of certain types of transport vesicles or may be constitutive vesicular transport to signal transduction path... | [
"GO:0003824"
] | [
"catalytic activity"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF00614",
"PS50035",
"SM00155"
] | [
"PLDc",
"PLD",
"PLDc"
] | [
21016,
92213,
75892
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC50035",
"R-BTA-1483166",
"R-BTA-2029485",
"R-CEL-1855204",
"R-CEL-2029485",
"R-DDI-1483166",
"R-DDI-1855204",
"R-DDI-2029485",
"R-DDI-6798695",
"R-DDI-9013149",
"R-DDI-9013404",
"R-DDI-9013408",
"R-HSA-1483148",
"R-HSA-1483166",
"R-HSA-1855204",
"R-HSA-2029485",
"R-HSA-5601884",... | [
"PROSITEDOC:PDOC50035",
"REACTOME:R-BTA-1483166",
"REACTOME:R-BTA-2029485",
"REACTOME:R-CEL-1855204",
"REACTOME:R-CEL-2029485",
"REACTOME:R-DDI-1483166",
"REACTOME:R-DDI-1855204",
"REACTOME:R-DDI-2029485",
"REACTOME:R-DDI-6798695",
"REACTOME:R-DDI-9013149",
"REACTOME:R-DDI-9013404",
"REACTOME:... | 48 | [
"1byr",
"1bys",
"1f0i",
"1v0r",
"1v0s",
"1v0t",
"1v0u",
"1v0v",
"1v0w",
"1v0y",
"1xdo",
"1xdp",
"2ze4",
"2ze9",
"3hsi",
"4ggj",
"4ggk",
"6ehi",
"6kz8",
"6kz9",
"6ohm",
"6oho",
"6ohp",
"6ohq",
"6ohr",
"6ohs",
"6u8z",
"7e0m",
"7jrb",
"7jrc",
"7jru",
"7jrv"... | 64 | [
"PUB00000088",
"PUB00002867",
"PUB00005043",
"PUB00005451"
] | [
"9242915",
"8051126",
"8732763",
"8755242"
] | [
"Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D.",
"Cloning and expression of phosphatidylcholine-hydrolyzing phospholipase D from Ricinus communis L.",
"A novel family of phospholipase D homologues that includes phospholipid synthases and putative endonucleases: iden... | [
1997,
1994,
1996,
1996
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Plasmid R64",
"Viruses",
"unclassified sequences"
] | [
869,
59052,
32345,
1,
532,
557
] | 6 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
66,
9,
30,
9,
6,
30,
21,
7,
52,
32,
2,
2,
127
] | 13 | true | Domain | Phospholipase D/Transphosphatidylase | Phospholipase D/Transphosphatidylase | PLipase_D/transphosphatidylase | 8 |
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