interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR001874 | 1,874 | Dehydroquinase, class II | DHquinase_II | Family | 23,602 | false | false | 3-dehydroquinate dehydratase ( ), or dehydroquinase, catalyzes the conversion of 3-dehydroquinate into 3-dehydroshikimate. It is the third step in the shikimate pathway for the biosynthesis of aromatic amino acids from chorismate. Two classes of dehydroquinases exist, known as types I and II. Class-II enzymes are homod... | [
"GO:0003855"
] | [
"3-dehydroquinate dehydratase activity"
] | [
"molecular_function"
] | 1 | [
"HAMAP",
"PFAM",
"PIRSF",
"PANTHER",
"NCBIFAM",
"CDD"
] | [
"MF_00169",
"PF01220",
"PIRSF001399",
"PTHR21272",
"TIGR01088",
"cd00466"
] | [
"AroQ",
"DHquinase_II",
"DHquinase_II",
"",
"aroQ",
"DHQase_II"
] | [
23187,
23555,
23042,
23428,
20156,
23082
] | 6 | [
"EC",
"GP",
"METACYC",
"METACYC",
"METACYC",
"PROSITEDOC",
"REACTOME"
] | [
"4.2.1.10",
"GenProp0001",
"PWY-6163",
"PWY-6416",
"PWY-6707",
"PDOC00789",
"R-MTU-964903"
] | [
"EC:4.2.1.10",
"GP:GenProp0001",
"METACYC:PWY-6163",
"METACYC:PWY-6416",
"METACYC:PWY-6707",
"PROSITEDOC:PDOC00789",
"REACTOME:R-MTU-964903"
] | 7 | [
"1d0i",
"1gqo",
"1gtz",
"1gu0",
"1gu1",
"1h05",
"1h0r",
"1h0s",
"1j2y",
"1uqr",
"1v1j",
"2bt4",
"2c4v",
"2c4w",
"2c57",
"2cjf",
"2dhq",
"2uyg",
"2wks",
"2xb8",
"2xb9",
"2xd9",
"2xda",
"2y71",
"2y76",
"2y77",
"3kip",
"3lwz",
"3n59",
"3n76",
"3n7a",
"3n86"... | 79 | [
"PUB00003743",
"PUB00003855"
] | [
"1910148",
"8170389"
] | [
"The Mycobacterium tuberculosis shikimate pathway genes: evolutionary relationship between biosynthetic and catabolic 3-dehydroquinases.",
"Characterization of a 3-dehydroquinase gene from Actinobacillus pleuropneumoniae with homology to the eukaryotic genes qa-2 and QUTE."
] | [
1991,
1994
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriati",
"unclassified sequences"
] | [
21926,
1120,
2,
554
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | Dehydroquinase, class II | Dehydroquinase, class II | DHquinase_II | 7 |
IPR001875 | 1,875 | Death effector domain | DED_dom | Domain | 9,324 | false | false | The death effector domain (DED) is a homotypic protein interaction module composed of a bundle of six α-helices. DED is related in sequence and structure to the death domain (DD, see ) and the caspase recruitment domain (CARD, see ), which work in similar pathways and show similar interaction properties [ ]. The dimeri... | [
"GO:0005515",
"GO:0042981"
] | [
"protein binding",
"regulation of apoptotic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF01335",
"PS50168",
"SM00031"
] | [
"DED",
"DED",
"DED"
] | [
7324,
9296,
6913
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC50168",
"R-BTA-140534",
"R-BTA-2562578",
"R-BTA-3371378",
"R-BTA-5218900",
"R-BTA-5357786",
"R-BTA-5357905",
"R-BTA-5675482",
"R-BTA-69416",
"R-BTA-75157",
"R-HSA-111465",
"R-HSA-112409",
"R-HSA-140534",
"R-HSA-168638",
"R-HSA-2562578",
"R-HSA-264870",
"R-HSA-3371378",
"R-HSA-... | [
"PROSITEDOC:PDOC50168",
"REACTOME:R-BTA-140534",
"REACTOME:R-BTA-2562578",
"REACTOME:R-BTA-3371378",
"REACTOME:R-BTA-5218900",
"REACTOME:R-BTA-5357786",
"REACTOME:R-BTA-5357905",
"REACTOME:R-BTA-5675482",
"REACTOME:R-BTA-69416",
"REACTOME:R-BTA-75157",
"REACTOME:R-HSA-111465",
"REACTOME:R-HSA-... | 72 | [
"1a1w",
"1a1z",
"1n3k",
"2bbr",
"2bbz",
"2f1s",
"2gf5",
"2ls7",
"3cl3",
"4iz5",
"4iz7",
"4iza",
"4zbw",
"5h31",
"5h33",
"5jqe",
"5l08",
"5lde",
"6agw",
"6m6o",
"6p6b",
"6p6c",
"7dee",
"7lvj",
"7lvm",
"7lxc",
"7pdj",
"8ybx",
"8yd7",
"8yd8",
"8ym4",
"8ym5"... | 41 | [
"PUB00015010",
"PUB00015013",
"PUB00015057"
] | [
"15173180",
"11504623",
"15226512"
] | [
"Direct binding of Fas-associated death domain (FADD) to the tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 is regulated by the death effector domain of FADD.",
"The death domain superfamily: a tale of two interfaces?",
"The domains of apoptosis: a genomics perspective."
] | [
2004,
2001,
2004
] | 3 | [] | [
"IPR029546"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"Viruses",
"metagenomes"
] | [
169,
9089,
2,
55,
9
] | 5 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
13,
51,
20,
17
] | 4 | true | Domain | Death effector domain | Death effector domain | DED_dom | 8 |
IPR001879 | 1,879 | GPCR, family 2, extracellular hormone receptor domain | GPCR_2_extracellular_dom | Domain | 46,667 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0004930",
"GO:0016020"
] | [
"G protein-coupled receptor activity",
"membrane"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF02793",
"PS50227",
"SM00008"
] | [
"HRM",
"G_PROTEIN_RECEP_F2_3",
"HormR"
] | [
37549,
46443,
40788
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00559",
"R-BTA-418555",
"R-BTA-420092",
"R-CEL-419812",
"R-CFA-373080",
"R-DME-350368",
"R-DME-350376",
"R-DME-350379",
"R-DME-350411",
"R-DME-350480",
"R-DME-450728",
"R-DRE-419812",
"R-HSA-163359",
"R-HSA-187024",
"R-HSA-373080",
"R-HSA-381676",
"R-HSA-416476",
"R-HSA-418555... | [
"PROSITEDOC:PDOC00559",
"REACTOME:R-BTA-418555",
"REACTOME:R-BTA-420092",
"REACTOME:R-CEL-419812",
"REACTOME:R-CFA-373080",
"REACTOME:R-DME-350368",
"REACTOME:R-DME-350376",
"REACTOME:R-DME-350379",
"REACTOME:R-DME-350411",
"REACTOME:R-DME-350480",
"REACTOME:R-DME-450728",
"REACTOME:R-DRE-4198... | 43 | [
"1u34",
"2jnc",
"2jnd",
"2jod",
"2l27",
"2qkh",
"2x57",
"2xdg",
"3aqf",
"3c4m",
"3c59",
"3c5t",
"3ehs",
"3eht",
"3ehu",
"3h3g",
"3iol",
"3l2j",
"3n7p",
"3n7r",
"3n7s",
"3n93",
"3n94",
"3n95",
"3n96",
"4dlo",
"4dlq",
"4ers",
"4hj0",
"4lf3",
"4rwf",
"4rwg"... | 227 | [
"PUB00001208",
"PUB00004310",
"PUB00004961",
"PUB00005147",
"PUB00005148",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816"
] | [
"1646711",
"1314625",
"8170923",
"1658940",
"1658941",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293"
] | [
"Molecular cloning and expression of a cDNA encoding the secretin receptor.",
"Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide.",
"Fingerprinting G-protein-coupled receptors.",
"Expression cloning of an adenylate cyclase-coupled calcitonin receptor.",
... | [
1991,
1992,
1994,
1991,
1991,
2003,
1994,
2005,
2009,
2006,
2013
] | 11 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"freshwater metagenome"
] | [
10,
46656,
1
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
320,
21,
121,
106,
170
] | 6 | true | Domain | GPCR, family 2, extracellular hormone receptor domain | GPCR, family 2, extracellular hormone receptor domain | GPCR_2_extracellular_dom | 8 |
IPR001881 | 1,881 | EGF-like calcium-binding domain | EGF-like_Ca-bd_dom | Domain | 225,811 | false | false | A sequence of about forty amino-acid residues found in epidermal growth factor (EGF) has been shown [ , , , , ] to be present in a large number of membrane-bound and extracellular, mostly animal, proteins. Many of these proteins require calcium for their biological function, and a calcium-binding site has been found at... | [
"GO:0005509"
] | [
"calcium ion binding"
] | [
"molecular_function"
] | 1 | [
"SMART"
] | [
"SM00179"
] | [
"EGF_CA"
] | [
225811
] | 1 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00913",
"R-BTA-114608",
"R-BTA-140834",
"R-BTA-140837",
"R-BTA-140875",
"R-BTA-1474228",
"R-BTA-1566948",
"R-BTA-159740",
"R-BTA-159763",
"R-BTA-159782",
"R-BTA-1971475",
"R-BTA-2022870",
"R-BTA-2022923",
"R-BTA-2024101",
"R-BTA-202733",
"R-BTA-2129379",
"R-BTA-216083",
"R-BTA... | [
"PROSITEDOC:PDOC00913",
"REACTOME:R-BTA-114608",
"REACTOME:R-BTA-140834",
"REACTOME:R-BTA-140837",
"REACTOME:R-BTA-140875",
"REACTOME:R-BTA-1474228",
"REACTOME:R-BTA-1566948",
"REACTOME:R-BTA-159740",
"REACTOME:R-BTA-159763",
"REACTOME:R-BTA-159782",
"REACTOME:R-BTA-1971475",
"REACTOME:R-BTA-2... | 448 | [
"1apo",
"1apq",
"1aut",
"1bf9",
"1c5m",
"1ccf",
"1dan",
"1dva",
"1dx5",
"1edm",
"1emn",
"1emo",
"1ezq",
"1f0r",
"1f0s",
"1f7e",
"1f7m",
"1fak",
"1fax",
"1ff7",
"1ffm",
"1g2l",
"1g2m",
"1hj7",
"1hz8",
"1i0u",
"1ioe",
"1iqe",
"1iqf",
"1iqg",
"1iqh",
"1iqi"... | 296 | [
"PUB00000923",
"PUB00001555",
"PUB00002741",
"PUB00003983",
"PUB00004321",
"PUB00004609",
"PUB00004964"
] | [
"7606779",
"3282918",
"1527084",
"6607417",
"2288911",
"6334307",
"3534958"
] | [
"The structure of a Ca(2+)-binding epidermal growth factor-like domain: its role in protein-protein interactions.",
"Structure and function of epidermal growth factor-like regions in proteins.",
"How an epidermal growth factor (EGF)-like domain binds calcium. High resolution NMR structure of the calcium form of... | [
1995,
1988,
1992,
1984,
1990,
1984,
1986
] | 7 | [
"IPR000742"
] | [
"IPR049883"
] | 1 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"organismal metagenomes"
] | [
175,
225631,
5
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
66,
101,
652,
115,
618,
405,
252,
598,
126
] | 9 | true | Domain | EGF-like calcium-binding domain | EGF-like calcium-binding domain | EGF-like_Ca-bd_dom | 2 |
IPR001882 | 1,882 | Biotin-binding site | Biotin_BS | Binding_site | 69,496 | false | false | Biotin, which plays a catalytic role in some carboxyl transfer reactions, is covalently attached, via an amide bond, to a lysine residue in enzymes requiring this coenzyme [ , , , ]. Sequence data reveal that the region around the biocytin (biotin-lysine) residue is well conserved and is evolutionary related to that ar... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS00188"
] | [
"BIOTIN"
] | [
69496
] | 1 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00167",
"R-BTA-196780",
"R-BTA-70263",
"R-BTA-70268",
"R-CEL-196780",
"R-CEL-71032",
"R-DDI-196780",
"R-DDI-200425",
"R-DDI-70895",
"R-DDI-75105",
"R-HSA-163765",
"R-HSA-196780",
"R-HSA-200425",
"R-HSA-2426168",
"R-HSA-3371599",
"R-HSA-70263",
"R-HSA-70268",
"R-HSA-70895",
"... | [
"PROSITEDOC:PDOC00167",
"REACTOME:R-BTA-196780",
"REACTOME:R-BTA-70263",
"REACTOME:R-BTA-70268",
"REACTOME:R-CEL-196780",
"REACTOME:R-CEL-71032",
"REACTOME:R-DDI-196780",
"REACTOME:R-DDI-200425",
"REACTOME:R-DDI-70895",
"REACTOME:R-DDI-75105",
"REACTOME:R-HSA-163765",
"REACTOME:R-HSA-196780",
... | 47 | [
"1a6x",
"1bdo",
"1dcz",
"1dd2",
"1o78",
"2bdo",
"2d5d",
"2ejf",
"2ejg",
"2ejm",
"2evb",
"2jku",
"2qf7",
"3bdo",
"3bg3",
"3bg9",
"3n6r",
"3tw6",
"3tw7",
"3va7",
"4hr7",
"5csa",
"5csk",
"5csl",
"5gu8",
"5gu9",
"5gua",
"5i8i",
"5ks8",
"5mlk",
"6g2d",
"6g2h"... | 96 | [
"PUB00000064",
"PUB00002482",
"PUB00002740",
"PUB00003560"
] | [
"2673009",
"2896195",
"1526981",
"6438443"
] | [
"The mechanism of biotin-dependent enzymes.",
"Evolutionary conservation among biotin enzymes.",
"The importance of methionine residues for the catalysis of the biotin enzyme, transcarboxylase. Analysis by site-directed mutagenesis.",
"Formation of N epsilon-(biotinyl)lysine in biotin enzymes."
] | [
1989,
1988,
1992,
1984
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
699,
51982,
16016,
799
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
19,
2,
35,
9,
1,
13,
12,
2,
2,
28,
5,
2,
7
] | 13 | true | Binding_site | Biotin-binding site | Biotin-binding site | Biotin_BS | 8 |
IPR001883 | 1,883 | GPCR, family 3, metabotropic glutamate receptor 7 | GPCR_3_mGluR7 | Family | 1,296 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0007186",
"GO:0016020"
] | [
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01057"
] | [
"MTABOTROPC7R"
] | [
1296
] | 1 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"295",
"R-HSA-418594",
"R-HSA-420499",
"R-MMU-418594",
"R-MMU-420499",
"R-RNO-418594",
"R-RNO-420499"
] | [
"IUPHAR:295",
"REACTOME:R-HSA-418594",
"REACTOME:R-HSA-420499",
"REACTOME:R-MMU-418594",
"REACTOME:R-MMU-420499",
"REACTOME:R-RNO-418594",
"REACTOME:R-RNO-420499"
] | 7 | [
"2e4z",
"3mq4",
"5c5c",
"9omo",
"9omp"
] | 5 | [
"PUB00000774",
"PUB00002720",
"PUB00002840",
"PUB00004090",
"PUB00004161",
"PUB00004309",
"PUB00004961",
"PUB00005138",
"PUB00007343",
"PUB00036049",
"PUB00036050",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816"
] | [
"8840028",
"1320017",
"8288585",
"1847995",
"8255296",
"1309649",
"8170923",
"1656524",
"9292726",
"17266540",
"10773016",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293"
] | [
"Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS.",
"Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction.",
"Molecular characterization of a new metabotropic glutamate receptor mGluR7... | [
1996,
1992,
1994,
1991,
1993,
1992,
1994,
1991,
1997,
2007,
2000,
2003,
1994,
2005,
2009,
2006,
2013
] | 17 | [
"IPR000162"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
1296
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
8,
6,
8
] | 4 | true | Family | GPCR, family 3, metabotropic glutamate receptor 7 | GPCR, family 3, metabotropic glutamate receptor 7 | GPCR_3_mGluR7 | 3 |
IPR001884 | 1,884 | Translation elongation factor IF5A-like | IF5A-like | Family | 10,347 | false | false | Eukaryotic eIF-5A was initially thought to function as a translation initiation factor, based on its ability to stimulate methionyl-puromycin synthesis. However, subsequent work revealed a role for eIF5A in translation elongation [ , ]. Depletion or inactivation of eIF-5A in the yeast Saccharomyces cerevisiae (Baker's ... | [
"GO:0003723",
"GO:0003746",
"GO:0043022",
"GO:0006414"
] | [
"RNA binding",
"translation elongation factor activity",
"ribosome binding",
"translational elongation"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process"
] | 4 | [
"PIRSF",
"PANTHER",
"NCBIFAM"
] | [
"PIRSF003025",
"PTHR11673",
"TIGR00037"
] | [
"eIF5A",
"",
"eIF_5A"
] | [
7213,
10241,
8006
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC00274",
"R-BTA-204626",
"R-CEL-204626",
"R-DDI-204626",
"R-DME-204626",
"R-DRE-204626",
"R-GGA-204626",
"R-HSA-204626",
"R-MMU-204626",
"R-RNO-204626",
"R-SCE-204626",
"R-SPO-204626"
] | [
"PROSITEDOC:PDOC00274",
"REACTOME:R-BTA-204626",
"REACTOME:R-CEL-204626",
"REACTOME:R-DDI-204626",
"REACTOME:R-DME-204626",
"REACTOME:R-DRE-204626",
"REACTOME:R-GGA-204626",
"REACTOME:R-HSA-204626",
"REACTOME:R-MMU-204626",
"REACTOME:R-RNO-204626",
"REACTOME:R-SCE-204626",
"REACTOME:R-SPO-2046... | 12 | [
"1bkb",
"1eif",
"1iz6",
"1khi",
"1x6o",
"1xtd",
"2eif",
"3cpf",
"3er0",
"3hks",
"5dat",
"5dc3",
"5dge",
"5dgf",
"5dlq",
"5gak",
"5hy6",
"5mc6",
"6q84",
"6tnu",
"7asi",
"7asx",
"7n4d",
"7njh",
"7nji",
"7nrc",
"7oya",
"7oyc",
"7oyd",
"7rr5",
"8a0e",
"8aaf"... | 58 | [
"PUB00000742",
"PUB00003672",
"PUB00005808",
"PUB00010716",
"PUB00026734",
"PUB00046010",
"PUB00082267",
"PUB00090482",
"PUB00101067"
] | [
"8347280",
"1903841",
"9493264",
"9753699",
"12640443",
"19424157",
"23727016",
"28392174",
"23869404"
] | [
"Hypusine: its post-translational formation in eukaryotic initiation factor 5A and its potential role in cellular regulation.",
"Translation initiation factor 5A and its hypusine modification are essential for cell viability in the yeast Saccharomyces cerevisiae.",
"Crystal structure of the NAD complex of human... | [
1993,
1991,
1998,
1998,
2003,
2009,
2013,
2017,
2013
] | 9 | [] | [
"IPR022847"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Megaviricetes",
"metagenomes"
] | [
890,
8,
9391,
10,
48
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
8,
3,
6,
1,
8,
6,
2,
16,
7,
2,
2,
19
] | 12 | true | Family | Translation elongation factor IF5A-like | Translation elongation factor IF5A-like | IF5A-like | 9 |
IPR001885 | 1,885 | Lipoxygenase, mammalian | LipOase_mml | Family | 5,012 | false | false | Lipoxygenases ([ec:1.13.11.-]) are a class of iron-containing dioxygenases which catalyses the hydroperoxidation of lipids, containing a cis,cis-1,4-pentadiene structure. They are common in plants where they may be involved in a number of diverse aspects of plant physiology including growth and development, pest resist... | [
"GO:0005506",
"GO:0016702"
] | [
"iron ion binding",
"oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PRINTS"
] | [
"PR00467"
] | [
"MAMLPOXGNASE"
] | [
5012
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"... | [
"1.13.11",
"1.13.11.-",
"PWY-181",
"PWY-5163",
"PWY-5642",
"PWY-6068",
"PWY-6069",
"PWY-6084",
"PWY-6087",
"PWY-6089",
"PWY-6093",
"PWY-6094",
"PWY-6102",
"PWY-6107",
"PWY-6178",
"PWY-6190",
"PWY-6193",
"PWY-6336",
"PWY-6339",
"PWY-6667",
"PWY-7006",
"PWY-7009",
"PWY-7010... | [
"EC:1.13.11",
"EC:1.13.11.-",
"METACYC:PWY-181",
"METACYC:PWY-5163",
"METACYC:PWY-5642",
"METACYC:PWY-6068",
"METACYC:PWY-6069",
"METACYC:PWY-6084",
"METACYC:PWY-6087",
"METACYC:PWY-6089",
"METACYC:PWY-6093",
"METACYC:PWY-6094",
"METACYC:PWY-6102",
"METACYC:PWY-6107",
"METACYC:PWY-6178",... | 116 | [
"1lox",
"2fnq",
"2p0m",
"3d3l",
"3dy5",
"3fg1",
"3fg3",
"3fg4",
"3o8y",
"3rde",
"3v92",
"3v98",
"3v99",
"3vf1",
"4nre",
"4qwt",
"6n2w",
"6ncf",
"7laf",
"7ttj",
"7ttk",
"7ttl",
"8ghb",
"8ghc",
"8ghd",
"8ghe",
"8viy"
] | 27 | [
"PUB00000045",
"PUB00000363",
"PUB00002887",
"PUB00005162"
] | [
"3017195",
"1567851",
"7508918",
"8502991"
] | [
"Arachidonic acid metabolism.",
"Conserved histidine residues in soybean lipoxygenase: functional consequences of their replacement.",
"A novel lipoxygenase from rice. Primary structure and specific expression upon incompatible infection with rice blast fungus.",
"The three-dimensional structure of an arachid... | [
1986,
1992,
1994,
1993
] | 4 | [
"IPR000907"
] | [] | 1 | 0 | 1 | [
"Eukaryota",
"Thiohalocapsa halophila"
] | [
5011,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
44,
20,
22,
27
] | 4 | true | Family | Lipoxygenase, mammalian | Lipoxygenase, mammalian | LipOase_mml | 7 |
IPR001887 | 1,887 | Barnase | Barnase | Family | 1,220 | false | false | Barnase is the extracellular ribonuclease of Bacillus amyloliquefaciens, and barstar its specific intracellular inhibitor [ , ]. Expression of barstar is necessary to counter the lethal effect of expressed active barnase. Barnase hydrolyses phosphodiester bonds in RNA, poly- and oligo-ribonucleotides, resulting in 3'-n... | [
"GO:0003723",
"GO:0004521"
] | [
"RNA binding",
"RNA endonuclease activity"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PIRSF",
"PRINTS",
"CDD"
] | [
"PIRSF001013",
"PR00117",
"cd00933"
] | [
"Barnase",
"BARNASE",
"barnase"
] | [
620,
1183,
189
] | 3 | [
"EC"
] | [
"3.1.27.-"
] | [
"EC:3.1.27.-"
] | 1 | [
"1a2p",
"1b20",
"1b21",
"1b27",
"1b2s",
"1b2u",
"1b2x",
"1b2z",
"1b3s",
"1ban",
"1bao",
"1bgs",
"1bne",
"1bnf",
"1bng",
"1bni",
"1bnj",
"1bnr",
"1bns",
"1brg",
"1brh",
"1bri",
"1brj",
"1brk",
"1brn",
"1brs",
"1bsa",
"1bsb",
"1bsc",
"1bsd",
"1bse",
"1buj"... | 59 | [
"PUB00000354",
"PUB00003231",
"PUB00005346"
] | [
"1888730",
"3050134",
"2696173"
] | [
"Determination of the three-dimensional solution structure of barnase using nuclear magnetic resonance spectroscopy.",
"Barnase and barstar. Expression of its cloned inhibitor permits expression of a cloned ribonuclease.",
"Barnase and barstar: two small proteins to fold and fit together."
] | [
1991,
1988,
1989
] | 3 | [
"IPR000026"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Methanobacteriaceae",
"Phytophthora kernoviae 00238/432",
"bioreactor metagenome"
] | [
1197,
15,
1,
7
] | 4 | [] | [] | 0 | true | Family | Barnase | Barnase | Barnase | 2 |
IPR001888 | 1,888 | Transposase, type 1 | Transposase_1 | Family | 9,861 | false | false | Autonomous mobile genetic elements such as transposon or insertion sequences (IS) encode an enzyme, transposase, that is required for excising and inserting the mobile element. Transposases have been grouped into various families [ , , ]. This family includes the mariner transposase [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01359"
] | [
"Transposase_1"
] | [
9861
] | 1 | [] | [] | [] | 0 | [
"2f7t",
"3f2k",
"3hos",
"3hot",
"3k9j",
"3k9k",
"4mda",
"4mdb",
"4r79",
"4u7b",
"5hoo"
] | 11 | [
"PUB00001294",
"PUB00001812",
"PUB00003820",
"PUB00004452"
] | [
"8895590",
"1718819",
"1310791",
"8041625"
] | [
"A purified mariner transposase is sufficient to mediate transposition in vitro.",
"IS406 and IS407, two gene-activating insertion sequences for Pseudomonas cepacia.",
"Isolation and analysis of IS6120, a new insertion sequence from Mycobacterium smegmatis.",
"Sequence similarity of putative transposases link... | [
1996,
1991,
1992,
1994
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Nocardioides"
] | [
9859,
2
] | 2 | [
"Homo sapiens"
] | [
4
] | 1 | true | Family | Transposase, type 1 | Transposase, type 1 | Transposase_1 | 1 |
IPR001889 | 1,889 | Herpesvirus thymidine kinase | Herpes_TK | Family | 1,237 | false | false | The thymidine kinase from Herpesviridae catalyses the reaction: ATP + THYMIDINE = ADP + THYMIDINE 5'-PHOSPHATE. The enzyme is not subject to feedback inhibition by its product and the crystal structure of the enzyme from Human herpesvirus 1 (HHV-1) has been reported [ ]. | [
"GO:0004797",
"GO:0005524",
"GO:0006230"
] | [
"thymidine kinase activity",
"ATP binding",
"TMP biosynthetic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"HAMAP",
"PFAM"
] | [
"MF_04029",
"PF00693"
] | [
"HSV_KITH",
"Herpes_TK"
] | [
858,
1236
] | 2 | [
"EC",
"METACYC"
] | [
"2.7.1.21",
"PWY-7199"
] | [
"EC:2.7.1.21",
"METACYC:PWY-7199"
] | 2 | [
"1e2h",
"1e2i",
"1e2j",
"1e2k",
"1e2l",
"1e2m",
"1e2n",
"1e2p",
"1ki2",
"1ki3",
"1ki4",
"1ki6",
"1ki7",
"1ki8",
"1kim",
"1of1",
"1osn",
"1p6x",
"1p72",
"1p73",
"1p75",
"1p7c",
"1qhi",
"1vtk",
"2ki5",
"2vtk",
"3f0t",
"3rdp",
"3vtk",
"4ivp",
"4ivq",
"4ivr"... | 38 | [
"PUB00003924"
] | [
"7552712"
] | [
"Crystal structures of the thymidine kinase from herpes simplex virus type-1 in complex with deoxythymidine and ganciclovir."
] | [
1995
] | 1 | [] | [] | 0 | 0 | null | [
"Herpesvirales",
"Pseudomonadati"
] | [
1234,
3
] | 2 | [] | [] | 0 | true | Family | Herpesvirus thymidine kinase | Herpesvirus thymidine kinase | Herpes_TK | 2 |
IPR001890 | 1,890 | RNA-binding, CRM domain | RNA-binding_CRM | Domain | 19,987 | false | false | The CRM domain is an ~100-amino acid RNA-binding domain. The name chloroplast RNA splicing and ribosome maturation (CRM) has been suggested to reflect the functions established for the four characterised members of the family: Zea mays (Maize) CRS1 ( ), CAF1 ( ) and CAF2 ( ) proteins and the Escherichia coli protein Yh... | [
"GO:0003723"
] | [
"RNA binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF01985",
"PS51295",
"SM01103"
] | [
"CRS1_YhbY",
"CRM",
"CRS1_YhbY"
] | [
19867,
19931,
19643
] | 3 | [] | [] | [] | 0 | [
"1jo0",
"1ln4",
"1rq8",
"8a22",
"8apn",
"8apo"
] | 6 | [
"PUB00019352",
"PUB00019354",
"PUB00043746",
"PUB00043747",
"PUB00044700"
] | [
"12429100",
"11565746",
"12881426",
"17105995",
"18065687"
] | [
"Crystal structure of E. coli YhbY: a representative of a novel class of RNA binding proteins.",
"CRS1 is a novel group II intron splicing factor that was derived from a domain of ancient origin.",
"Group II intron splicing factors derived by diversification of an ancient RNA-binding domain.",
"The CRM domain... | [
2002,
2001,
2003,
2007,
2007
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
707,
10452,
8677,
151
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
74,
1,
42,
97
] | 4 | true | Domain | RNA-binding, CRM domain | RNA-binding, CRM domain | RNA-binding_CRM | 7 |
IPR001891 | 1,891 | Malic oxidoreductase | Malic_OxRdtase | Family | 38,323 | false | false | Malic enzymes (malate oxidoreductases) catalyse the oxidative decarboxylation of malate to form pyruvate, a reaction important in a number of metabolic pathways - e.g. carbon dioxide released from the reaction may be used in sugar production during the Calvin cycle of photosynthesis [ ]. There are 3 forms of the enzyme... | [
"GO:0004470",
"GO:0016616"
] | [
"malic enzyme activity",
"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PIRSF",
"PRINTS"
] | [
"PIRSF000106",
"PR00072"
] | [
"ME",
"MALOXRDTASE"
] | [
35272,
28793
] | 2 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.1.1",
"1.1.1.38",
"PWY-3641",
"PWY-7115",
"PWY-7118",
"PWY-7384",
"PWY-7686",
"R-HSA-1989781",
"R-HSA-70268",
"R-HSA-9818025",
"R-HSA-9837999",
"R-HSA-9861718",
"R-MMU-70268",
"R-MMU-9837999",
"R-MMU-9861718",
"R-RNO-70268",
"R-RNO-9861718"
] | [
"EC:1.1.1",
"EC:1.1.1.38",
"METACYC:PWY-3641",
"METACYC:PWY-7115",
"METACYC:PWY-7118",
"METACYC:PWY-7384",
"METACYC:PWY-7686",
"REACTOME:R-HSA-1989781",
"REACTOME:R-HSA-70268",
"REACTOME:R-HSA-9818025",
"REACTOME:R-HSA-9837999",
"REACTOME:R-HSA-9861718",
"REACTOME:R-MMU-70268",
"REACTOME:R... | 17 | [
"1do8",
"1efk",
"1efl",
"1gq2",
"1gz3",
"1gz4",
"1llq",
"1o0s",
"1pj2",
"1pj3",
"1pj4",
"1pjl",
"1qr6",
"1vl6",
"1ww8",
"2a9f",
"2aw5",
"2dvm",
"2hae",
"3nv9",
"3wja",
"5cee",
"5ou5",
"6ags",
"6c7n",
"6urf",
"6w29",
"6w2n",
"6w49",
"6w53",
"6w56",
"6w57"... | 52 | [
"PUB00000616",
"PUB00002681",
"PUB00002876",
"PUB00004541",
"PUB00057828"
] | [
"1911848",
"1993674",
"8300616",
"2103472",
"2644282"
] | [
"Duck liver malic enzyme: sequence of a tryptic peptide containing the cysteine residue labeled by the substrate analog bromopyruvate.",
"Human NAD(+)-dependent mitochondrial malic enzyme. cDNA cloning, primary structure, and expression in Escherichia coli.",
"Cloning and analysis of the C4 photosynthetic NAD-d... | [
1991,
1991,
1994,
1990,
1989
] | 5 | [] | [
"IPR023667",
"IPR048182"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
299,
22025,
15688,
311
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
25,
1,
6,
25,
1,
16,
10,
2,
31,
15,
1,
2,
87
] | 13 | true | Family | Malic oxidoreductase | Malic oxidoreductase | Malic_OxRdtase | 7 |
IPR001892 | 1,892 | Small ribosomal subunit protein uS13 | Ribosomal_uS13 | Family | 34,983 | false | false | Small ribosomal subunit protein uS13, previously known as Ribosomal protein S13, is one of the proteins from the small ribosomal subunit. In Escherichia coli, it is known to be involved in binding fMet-tRNA and, hence, in the initiation of translation. It is a basic protein of 115 to 177 amino-acid residues that contai... | [
"GO:0003723",
"GO:0003735",
"GO:0006412",
"GO:0005840"
] | [
"RNA binding",
"structural constituent of ribosome",
"translation",
"ribosome"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"HAMAP",
"PFAM",
"PIRSF"
] | [
"MF_01315",
"PF00416",
"PIRSF002134"
] | [
"Ribosomal_uS13",
"Ribosomal_S13",
"Ribosomal_S13"
] | [
30930,
34944,
31846
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00556",
"R-BTA-156827",
"R-BTA-1799339",
"R-BTA-6791226",
"R-BTA-72649",
"R-BTA-72689",
"R-BTA-72695",
"R-BTA-72702",
"R-BTA-72706",
"R-BTA-975956",
"R-BTA-975957",
"R-CFA-156827",
"R-CFA-1799339",
"R-CFA-72649",
"R-CFA-72689",
"R-CFA-72695",
"R-CFA-72702",
"R-CFA-72706",
"R... | [
"PROSITEDOC:PDOC00556",
"REACTOME:R-BTA-156827",
"REACTOME:R-BTA-1799339",
"REACTOME:R-BTA-6791226",
"REACTOME:R-BTA-72649",
"REACTOME:R-BTA-72689",
"REACTOME:R-BTA-72695",
"REACTOME:R-BTA-72702",
"REACTOME:R-BTA-72706",
"REACTOME:R-BTA-975956",
"REACTOME:R-BTA-975957",
"REACTOME:R-CFA-156827"... | 109 | [
"1fjg",
"1hnw",
"1hnx",
"1hnz",
"1hr0",
"1i94",
"1i95",
"1i96",
"1i97",
"1ibk",
"1ibl",
"1ibm",
"1j5e",
"1jgo",
"1jgp",
"1jgq",
"1mj1",
"1ml5",
"1n32",
"1n33",
"1n34",
"1n36",
"1vvj",
"1vy4",
"1vy5",
"1vy6",
"1vy7",
"1xmo",
"1xmq",
"1xnq",
"1xnr",
"2e5l"... | 1,801 | [
"PUB00000201",
"PUB00007068",
"PUB00007069",
"PUB00007070",
"PUB00059102"
] | [
"1872840",
"11297922",
"11290319",
"11114498",
"22096102"
] | [
"The primary structure of rat ribosomal protein S18.",
"Atomic structures at last: the ribosome in 2000.",
"The ribosome in focus.",
"The end of the beginning: structural studies of ribosomal proteins.",
"The structure of the eukaryotic ribosome at 3.0 A resolution."
] | [
1991,
2001,
2001,
2000,
2011
] | 5 | [] | [
"IPR019977",
"IPR019980"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
912,
23339,
10241,
491
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
12,
1,
2,
3,
1,
2,
5,
2,
14,
7,
3,
3,
27
] | 13 | true | Family | Small ribosomal subunit protein uS13 | Small ribosomal subunit protein uS13 | Ribosomal_uS13 | 9 |
IPR001894 | 1,894 | Cathelicidin-like | Cathelicidin-like | Family | 1,469 | false | false | Cathelicidins-related peptides from reptiles are also included in this family. They are potent antimicrobial peptides with low cytotoxicity, being interesting candidates as antimicrobial agents [ ]. Cathelicidins are antimicrobial peptides and, together with defensins, form a large group of cationic peptides with amphi... | [
"GO:0006952",
"GO:0005576"
] | [
"defense response",
"extracellular region"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PANTHER"
] | [
"PTHR10206"
] | [
""
] | [
1469
] | 1 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC00729",
"R-BTA-6798695",
"R-BTA-6803157",
"R-GGA-6798695",
"R-GGA-6803157",
"R-HSA-6798695",
"R-HSA-6803157",
"R-MMU-6798695",
"R-MMU-6803157"
] | [
"PROSITEDOC:PDOC00729",
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-6803157",
"REACTOME:R-GGA-6798695",
"REACTOME:R-GGA-6803157",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-6803157",
"REACTOME:R-MMU-6798695",
"REACTOME:R-MMU-6803157"
] | 9 | [
"1kwi",
"1lxe",
"1n5h",
"1n5p",
"1pfp",
"4eyc"
] | 6 | [
"PUB00001695",
"PUB00048248",
"PUB00095113",
"PUB00095114"
] | [
"7589491",
"18818205",
"23065264",
"25100358"
] | [
"Cathelicidins: a novel protein family with a common proregion and a variable C-terminal antimicrobial domain.",
"Structures of human host defense cathelicidin LL-37 and its smallest antimicrobial peptide KR-12 in lipid micelles.",
"Cathelicidins: family of antimicrobial peptides. A review.",
"Vipericidins: a... | [
1995,
2008,
2012,
2014
] | 4 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
1469
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
5,
5
] | 3 | true | Family | Cathelicidin-like | Cathelicidin-like | Cathelicidin-like | 9 |
IPR001895 | 1,895 | Ras guanine-nucleotide exchange factors catalytic domain | RASGEF_cat_dom | Domain | 64,128 | false | false | This entry represents the catalytic domain of the Ras guanine-nucleotide exchange factors. Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP [ ] in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. The balance... | [
"GO:0005085",
"GO:0007264"
] | [
"guanyl-nucleotide exchange factor activity",
"small GTPase-mediated signal transduction"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PROFILE",
"SMART",
"CDD"
] | [
"PF00617",
"PS50009",
"SM00147",
"cd00155"
] | [
"RasGEF",
"RASGEF_CAT",
"RasGEF",
"RasGEF"
] | [
63783,
62801,
61494,
44617
] | 4 | [
"GP",
"GP",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REA... | [
"GenProp1511",
"GenProp1548",
"PDOC00594",
"R-BTA-354192",
"R-BTA-392517",
"R-BTA-5673001",
"R-CEL-1433557",
"R-CEL-1433559",
"R-CEL-179812",
"R-CEL-180336",
"R-CEL-1855204",
"R-CEL-186763",
"R-CEL-193648",
"R-CEL-1963640",
"R-CEL-2179392",
"R-CEL-354192",
"R-CEL-354194",
"R-CEL-37... | [
"GP:GenProp1511",
"GP:GenProp1548",
"PROSITEDOC:PDOC00594",
"REACTOME:R-BTA-354192",
"REACTOME:R-BTA-392517",
"REACTOME:R-BTA-5673001",
"REACTOME:R-CEL-1433557",
"REACTOME:R-CEL-1433559",
"REACTOME:R-CEL-179812",
"REACTOME:R-CEL-180336",
"REACTOME:R-CEL-1855204",
"REACTOME:R-CEL-186763",
"RE... | 234 | [
"1bkd",
"1nvu",
"1nvv",
"1nvw",
"1nvx",
"1xd2",
"1xd4",
"1xdv",
"2byv",
"2ii0",
"2ije",
"3cf6",
"3ksy",
"3qxl",
"3t6a",
"3t6g",
"4f7z",
"4jgw",
"4l9m",
"4mgi",
"4mgk",
"4mgy",
"4mgz",
"4mh0",
"4nyi",
"4nyj",
"4nym",
"4uru",
"4urv",
"4urw",
"4urx",
"4ury"... | 116 | [
"PUB00000728",
"PUB00001017",
"PUB00001237",
"PUB00004087",
"PUB00004162",
"PUB00081668"
] | [
"7786285",
"15335949",
"8094051",
"1898771",
"8259209",
"9438849"
] | [
"Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins.",
"Ras regulation: putting back the GTP.",
"Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase.",
"The GTPase superfamily: conserved structure and molecular mechanism.",
"Proteins regu... | [
1995,
1992,
1993,
1991,
1993,
1998
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"organismal metagenomes"
] | [
154,
63948,
24,
2
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
26,
325,
37,
176,
103,
4,
148,
5,
2
] | 9 | true | Domain | Ras guanine-nucleotide exchange factors catalytic domain | Ras guanine-nucleotide exchange factors catalytic domain | RASGEF_cat_dom | 1 |
IPR001896 | 1,896 | Plant virus coat protein | Plant_vir_prot | Family | 1,484 | false | false | This family of membrane/coat proteins are found in a number of different ssRNA plant virus families that include Potexvirus, Hordeivirus and Carlavirus. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01307"
] | [
"Plant_vir_prot"
] | [
1484
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses"
] | [
2,
4,
1478
] | 3 | [] | [] | 0 | true | Family | Plant virus coat protein | Plant virus coat protein | Plant_vir_prot | 9 |
IPR001897 | 1,897 | Porin, gammaproteobacterial | Porin_gammaproteobac | Family | 10,045 | false | false | Porins are found in the outer membranes of Gram-negative bacteria, mitochondria and chloroplasts, where they form ion-selective channels for small hydrophilic molecules (up to ~600 D) [ , ]. X-ray structure analyses of several bacterial porins [ , , ] have revealed a 16-stranded anti-parallel β-barrel structure enclosi... | [
"GO:0015288",
"GO:0034220",
"GO:0009279",
"GO:0016020"
] | [
"porin activity",
"monoatomic ion transmembrane transport",
"cell outer membrane",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component",
"cellular_component"
] | 4 | [
"PRINTS"
] | [
"PR00183"
] | [
"ECOLIPORIN"
] | [
10045
] | 1 | [] | [] | [] | 0 | [
"1bt9",
"1gfm",
"1gfn",
"1gfo",
"1gfp",
"1gfq",
"1hxt",
"1hxu",
"1hxx",
"1mpf",
"1opf",
"1osm",
"1pho",
"2j1n",
"2j4u",
"2omf",
"2xe1",
"2xe2",
"2xe3",
"2xe5",
"2xg6",
"2zfg",
"2zld",
"2zle",
"3fyx",
"3hw9",
"3hwb",
"3k19",
"3k1b",
"3nb3",
"3nsg",
"3o0e"... | 93 | [
"PUB00001604",
"PUB00003334",
"PUB00003475",
"PUB00003829",
"PUB00005073"
] | [
"1707373",
"7525973",
"1725488",
"1373213",
"2178269"
] | [
"The structure of porin from Rhodobacter capsulatus at 1.8 A resolution.",
"Refined structure of the porin from Rhodopseudomonas blastica. Comparison with the porin from Rhodobacter capsulatus.",
"A common channel-forming motif in evolutionarily distant porins.",
"Porins and specific channels of bacterial out... | [
1991,
1994,
1991,
1992,
1990
] | 5 | [
"IPR001702"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"metagenomes"
] | [
10016,
9,
12,
8
] | 4 | [
"Escherichia coli (strain K12)"
] | [
8
] | 1 | true | Family | Porin, gammaproteobacterial | Porin, gammaproteobacterial | Porin_gammaproteobac | 9 |
IPR001900 | 1,900 | Ribonuclease II/R | RNase_II/R | Domain | 46,563 | false | false | This entry represents the catalytic domain of ribonuclease II [ ]. It includes characterised and related sequences to exoribonuclease II (RNase II) and ribonuclease R, a bacterial 3' --> 5' exoribonuclease homologous to RNase II [ , , ]. | [
"GO:0003723",
"GO:0004540"
] | [
"RNA binding",
"RNA nuclease activity"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM",
"SMART"
] | [
"PF00773",
"SM00955"
] | [
"RNB",
"RNB"
] | [
46552,
45360
] | 2 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.1.13.1",
"PDOC00904",
"R-CEL-429958",
"R-CEL-450385",
"R-CEL-450513",
"R-CEL-9930044",
"R-HSA-1368108",
"R-HSA-1989781",
"R-HSA-2151201",
"R-HSA-2426168",
"R-HSA-380994",
"R-HSA-381340",
"R-HSA-400206",
"R-HSA-429958",
"R-HSA-450385",
"R-HSA-450513",
"R-HSA-450604",
"R-HSA-67912... | [
"EC:3.1.13.1",
"PROSITEDOC:PDOC00904",
"REACTOME:R-CEL-429958",
"REACTOME:R-CEL-450385",
"REACTOME:R-CEL-450513",
"REACTOME:R-CEL-9930044",
"REACTOME:R-HSA-1368108",
"REACTOME:R-HSA-1989781",
"REACTOME:R-HSA-2151201",
"REACTOME:R-HSA-2426168",
"REACTOME:R-HSA-380994",
"REACTOME:R-HSA-381340",
... | 36 | [
"2id0",
"2ix0",
"2ix1",
"2r7d",
"2r7f",
"2vnu",
"2wp8",
"4ifd",
"4pmw",
"4ro1",
"5c0w",
"5c0x",
"5g06",
"5jea",
"5k36",
"5vzj",
"5xgu",
"6d6q",
"6d6r",
"6f3h",
"6f4a",
"6fsz",
"6h25",
"6lqs",
"7ajt",
"7aju",
"7am1",
"7d4i",
"7dcy",
"7dic",
"7did",
"7dol"... | 48 | [
"PUB00015537",
"PUB00017190",
"PUB00017191",
"PUB00045119"
] | [
"11948193",
"15604703",
"9829834",
"16806266"
] | [
"Purification and characterization of the Escherichia coli exoribonuclease RNase R. Comparison with RNase II.",
"Ribosomal RNA processing and an RNase R family member in chloroplasts of Arabidopsis.",
"The yeast nuclear gene DSS1, which codes for a putative RNase II, is necessary for the function of the mitocho... | [
2002,
2004,
1998,
2006
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
400,
28860,
16738,
16,
549
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
14,
2,
11,
7,
2,
12,
11,
3,
11,
21,
3,
5,
36
] | 13 | true | Domain | Ribonuclease II/R | Ribonuclease II/R | RNase_II/R | 2 |
IPR001901 | 1,901 | Protein translocase complex, SecE/Sec61-gamma subunit | Translocase_SecE/Sec61-g | Family | 29,265 | false | false | Secretion across the inner membrane in some Gram-negative bacteria occurs via the preprotein translocase pathway. Proteins are produced in the cytoplasm as precursors, and require a chaperone subunit to direct them to the translocase component [ ]. From there, the mature proteins are either targeted to the outer membra... | [
"GO:0006605",
"GO:0006886",
"GO:0016020"
] | [
"protein targeting",
"intracellular protein transport",
"membrane"
] | [
"biological_process",
"biological_process",
"cellular_component"
] | 3 | [
"HAMAP",
"PFAM",
"PROSITE"
] | [
"MF_00422",
"PF00584",
"PS01067"
] | [
"SecE",
"SecE",
"SECE_SEC61G"
] | [
26720,
28862,
14195
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC00818",
"R-BTA-9609523",
"R-CEL-9609523",
"R-CFA-9609523",
"R-DDI-9609523",
"R-DME-9609523",
"R-HSA-1222387",
"R-HSA-1236974",
"R-HSA-1799339",
"R-HSA-9609523",
"R-HSA-9760173",
"R-MMU-9609523",
"R-SCE-9609523",
"R-SPO-9609523"
] | [
"PROSITEDOC:PDOC00818",
"REACTOME:R-BTA-9609523",
"REACTOME:R-CEL-9609523",
"REACTOME:R-CFA-9609523",
"REACTOME:R-DDI-9609523",
"REACTOME:R-DME-9609523",
"REACTOME:R-HSA-1222387",
"REACTOME:R-HSA-1236974",
"REACTOME:R-HSA-1799339",
"REACTOME:R-HSA-9609523",
"REACTOME:R-HSA-9760173",
"REACTOME:... | 14 | [
"1rh5",
"1rhz",
"2akh",
"2aki",
"2ww9",
"2wwa",
"2wwb",
"2yxq",
"2yxr",
"2zjs",
"2zqp",
"3bo0",
"3bo1",
"3din",
"3dkn",
"3dl8",
"3j45",
"3j46",
"3j7q",
"3j7r",
"3jc2",
"3mp7",
"4cg5",
"4cg6",
"4cg7",
"4v4n",
"4v6m",
"4v7i",
"5a6u",
"5abb",
"5aww",
"5ch4"... | 95 | [
"PUB00000955",
"PUB00004170",
"PUB00007064",
"PUB00007065",
"PUB00007066"
] | [
"9393849",
"8107851",
"2202721",
"11336818",
"10418149"
] | [
"Protein translocation in the three domains of life: variations on a theme.",
"Evolutionary conservation of components of the protein translocation complex.",
"The sec and prl genes of Escherichia coli.",
"SecB, a molecular chaperone with two faces.",
"Effects of pre-protein overexpression on SecB synthesis... | [
1997,
1994,
1990,
2001,
1999
] | 5 | [] | [
"IPR005807",
"IPR008158"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
753,
23162,
4905,
445
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
15,
1,
1,
6,
1,
1,
3,
1,
5,
10,
1,
1,
7
] | 13 | true | Family | Protein translocase complex, SecE/Sec61-gamma subunit | Protein translocase complex, SecE/Sec61-gamma subunit | Translocase_SecE/Sec61-g | 8 |
IPR001902 | 1,902 | SLC26A/SulP transporter | SLC26A/SulP_fam | Family | 66,639 | false | false | The SLC26A/SulP family is a large and ubiquitous family with members derived from archaea, bacteria, fungi, plants and animals. Many organisms including Bacillus subtilis, Synechocystis sp, Saccharomyces cerevisiae, Arabidopsis thaliana and Caenorhabditis elegans possess multiple SulP family paralogues. Many of these p... | [
"GO:0055085",
"GO:0016020"
] | [
"transmembrane transport",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PANTHER",
"NCBIFAM"
] | [
"PTHR11814",
"TIGR00815"
] | [
"",
"sulP"
] | [
66565,
28426
] | 2 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC00870",
"R-BTA-174362",
"R-BTA-427601",
"R-CEL-174362",
"R-CEL-427601",
"R-HSA-174362",
"R-HSA-3560792",
"R-HSA-427601",
"R-HSA-5619046",
"R-HSA-5619085",
"R-HSA-9662361",
"R-MMU-174362",
"R-MMU-427601",
"R-RNO-174362",
"R-RNO-427601",
"R-SCE-174362",
"R-SCE-427601",
"R-SPO-17... | [
"PROSITEDOC:PDOC00870",
"REACTOME:R-BTA-174362",
"REACTOME:R-BTA-427601",
"REACTOME:R-CEL-174362",
"REACTOME:R-CEL-427601",
"REACTOME:R-HSA-174362",
"REACTOME:R-HSA-3560792",
"REACTOME:R-HSA-427601",
"REACTOME:R-HSA-5619046",
"REACTOME:R-HSA-5619085",
"REACTOME:R-HSA-9662361",
"REACTOME:R-MMU-... | 20 | [
"2kln",
"3llo",
"3mgl",
"3oir",
"4dgf",
"4dgh",
"5eus",
"5euu",
"5euw",
"5eux",
"5euz",
"5ezb",
"6ki1",
"6rtc",
"6rtf",
"7ch1",
"7lgu",
"7lgw",
"7lh2",
"7lh3",
"7lhv",
"7s8x",
"7s9a",
"7s9b",
"7s9c",
"7s9d",
"7s9e",
"7sun",
"7v73",
"7v74",
"7v75",
"7wk1"... | 69 | [
"PUB00018267",
"PUB00072168",
"PUB00072277",
"PUB00075356"
] | [
"10662676",
"24710176",
"23506885",
"21070944"
] | [
"The STAS domain - a link between anion transporters and antisigma-factor antagonists.",
"Molecular architecture and the structural basis for anion interaction in prestin and SLC26 transporters.",
"The SLC26 gene family of anion transporters and channels.",
"Structure of a SLC26 anion transporter STAS domain ... | [
2000,
2014,
2013,
2010
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
127,
30068,
36050,
394
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
74,
15,
27,
16,
1,
53,
37,
3,
54,
41,
3,
3,
66
] | 13 | true | Family | SLC26A/SulP transporter | SLC26A/SulP transporter | SLC26A/SulP_fam | 9 |
IPR001903 | 1,903 | Spike glycoprotein fusion domain, Rhabdovirus | Rhabdo_glycop_FD | Domain | 6,142 | false | false | This entry represents the elongated fusion domain FD (also known as domain IV). The glycoprotein G from rhabdoviruses, such as rabies virus (RABV), Mokola virus (MOKV) and European bat lyssavirus 1 (EBLV) [ , , , , , ] attaches the virus to host cellular receptor, and induces endocytosis of the virion. It forms the gly... | [
"GO:0019031"
] | [
"viral envelope"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF00974"
] | [
"Rhabdo_glycop_FD"
] | [
6142
] | 1 | [] | [] | [] | 0 | [
"4d6w",
"5i2m",
"5i2s",
"5mdm",
"5oy9",
"5oyl",
"6lgw",
"6lgx",
"6tit",
"6tmr",
"7u9g",
"8a1e",
"8zhw",
"8zhz",
"9hgn",
"9hh9",
"9hhr",
"9i8q",
"9kef",
"9kep",
"9kfb"
] | 21 | [
"PUB00003167",
"PUB00005582",
"PUB00155794",
"PUB00155795",
"PUB00155796",
"PUB00155797"
] | [
"9000093",
"1660200",
"35714192",
"32150590",
"35985336",
"28188244"
] | [
"Low pH-induced pore formation by spike proteins of enveloped viruses.",
"Membrane fusion activity, oligomerization, and assembly of the rabies virus glycoprotein.",
"Structure of the rabies virus glycoprotein trimer bound to a prefusion-specific neutralizing antibody.",
"Crystal structure of Mokola virus gly... | [
1996,
1991,
2022,
2020,
2022,
2017
] | 6 | [] | [] | 0 | 0 | null | [
"Protostomia",
"Riboviria",
"Shewanella intestini"
] | [
29,
6112,
1
] | 3 | [] | [] | 0 | true | Domain | Spike glycoprotein fusion domain, Rhabdovirus | Spike glycoprotein fusion domain, Rhabdovirus | Rhabdo_glycop_FD | 6 |
IPR001905 | 1,905 | Ammonium transporter | Ammonium_transpt | Family | 40,771 | false | false | All functionally characterised members of the ammonium transporter family are ammonia or ammonium uptake transporters. Some, but not others, also transport methylammonium. Uptake of ammonium/ammonia by AtmB protein from E. coli is electrogenic. Following sequestration of NH4+ at the periplasmic face, NH4+ is deprotonat... | [
"GO:0008519",
"GO:0072488",
"GO:0016020"
] | [
"ammonium channel activity",
"ammonium transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PANTHER",
"NCBIFAM"
] | [
"PTHR43029",
"TIGR00836"
] | [
"",
"amt"
] | [
30501,
37137
] | 2 | [
"PROSITEDOC"
] | [
"PDOC00937"
] | [
"PROSITEDOC:PDOC00937"
] | 1 | [
"1u77",
"1u7c",
"1u7g",
"1xqe",
"1xqf",
"2b2f",
"2b2h",
"2b2i",
"2b2j",
"2nmr",
"2nop",
"2now",
"2npc",
"2npd",
"2npe",
"2npg",
"2npj",
"2npk",
"2ns1",
"2nuu",
"3c1g",
"3c1h",
"3c1i",
"3c1j",
"4nh2",
"5aex",
"5aez",
"5af1",
"5ah3",
"5aid",
"5fuf",
"6b21"... | 39 | [
"PUB00097855",
"PUB00097856"
] | [
"32662768",
"30211659"
] | [
"A two-lane mechanism for selective biological ammonium transport.",
"The lipid environment determines the activity of the Escherichia coli ammonium transporter AmtB."
] | [
2020,
2019
] | 2 | [] | [
"IPR019879"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
615,
26233,
13333,
590
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosacchar... | [
22,
4,
1,
1,
4,
23,
3,
3,
22
] | 9 | true | Family | Ammonium transporter | Ammonium transporter | Ammonium_transpt | 1 |
IPR001906 | 1,906 | Terpene synthase, N-terminal domain | Terpene_synth_N | Domain | 22,613 | false | false | Sequences containing this domain belong to the terpene synthase family [ ]. It has been suggested that this gene family be designated tps (for terpene synthase). Sequence comparisons reveal similarities between the monoterpene (C 10 ) synthases, sesquiterpene (C 15 ) synthases and the diterpene (C 20 ) synthases. It ha... | [
"GO:0010333",
"GO:0016829"
] | [
"terpene synthase activity",
"lyase activity"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM"
] | [
"PF01397"
] | [
"Terpene_synth"
] | [
22613
] | 1 | [
"EC",
"GP",
"GP",
"GP",
"GP",
"GP"
] | [
"4.2.3",
"GenProp1471",
"GenProp1638",
"GenProp1709",
"GenProp1739",
"GenProp1760"
] | [
"EC:4.2.3",
"GP:GenProp1471",
"GP:GenProp1638",
"GP:GenProp1709",
"GP:GenProp1739",
"GP:GenProp1760"
] | 6 | [
"1hx9",
"1hxa",
"1hxc",
"1hxg",
"1n1b",
"1n1z",
"1n20",
"1n21",
"1n22",
"1n23",
"1n24",
"2j5c",
"2ong",
"2onh",
"3g4d",
"3g4f",
"3lz9",
"3m00",
"3m01",
"3m02",
"3n0f",
"3n0g",
"3p5p",
"3p5r",
"3pya",
"3pyb",
"3s9v",
"3sae",
"3sdq",
"3sdr",
"3sdt",
"3sdu"... | 94 | [
"PUB00002995",
"PUB00011119",
"PUB00097281"
] | [
"9268308",
"9268298",
"28841019"
] | [
"Monoterpene synthases from grand fir (Abies grandis). cDNA isolation, characterization, and functional expression of myrcene synthase, (-)-(4S)-limonene synthase, and (-)-(1S,5S)-pinene synthase.",
"Ent-kaurene synthase from the fungus Phaeosphaeria sp. L487. cDNA isolation, characterization, and bacterial expre... | [
1997,
1997,
2017
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati"
] | [
22610,
3
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
151,
132,
183
] | 3 | true | Domain | Terpene synthase, N-terminal domain | Terpene synthase, N-terminal domain | Terpene_synth_N | 8 |
IPR001907 | 1,907 | ATP-dependent Clp protease proteolytic subunit | ClpP | Family | 72,797 | false | false | Clp is an ATP-dependent protease that cleaves a number of proteins, such as casein and albumin [ ] and is a member of peptidase family S14. It exists as a heterodimer of ATP-binding regulatory A and catalytic P subunits, both of which are required for effective levels of protease activity in the presence of ATP [ , ], ... | [
"GO:0004176",
"GO:0004252",
"GO:0006508"
] | [
"ATP-dependent peptidase activity",
"serine-type endopeptidase activity",
"proteolysis"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"HAMAP",
"PRINTS",
"NCBIFAM",
"CDD"
] | [
"MF_00444",
"PR00127",
"TIGR00493",
"cd07017"
] | [
"ClpP",
"CLPPROTEASEP",
"clpP",
"S14_ClpP_2"
] | [
56921,
72330,
15058,
64039
] | 4 | [
"EC",
"GP",
"GP",
"GP",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.4.21.92",
"GenProp0251",
"GenProp1108",
"GenProp1137",
"PDOC00358",
"R-BTA-9837999",
"R-CEL-9837999",
"R-HSA-9837999",
"R-MMU-9837999"
] | [
"EC:3.4.21.92",
"GP:GenProp0251",
"GP:GenProp1108",
"GP:GenProp1137",
"PROSITEDOC:PDOC00358",
"REACTOME:R-BTA-9837999",
"REACTOME:R-CEL-9837999",
"REACTOME:R-HSA-9837999",
"REACTOME:R-MMU-9837999"
] | 9 | [
"1tg6",
"1tyf",
"1y7o",
"1yg6",
"1yg8",
"2c8t",
"2cby",
"2ce3",
"2f6i",
"2fzs",
"2zl0",
"2zl2",
"2zl3",
"2zl4",
"3hln",
"3ktg",
"3kth",
"3kti",
"3ktj",
"3ktk",
"3mt6",
"3p2l",
"3q7h",
"3qwd",
"3st9",
"3sta",
"3tt6",
"3tt7",
"3v5e",
"3v5i",
"4emm",
"4emp"... | 190 | [
"PUB00000953",
"PUB00002564",
"PUB00081432",
"PUB00081434",
"PUB00081435",
"PUB00081437",
"PUB00085963",
"PUB00085964"
] | [
"9390554",
"2197275",
"17499722",
"10320569",
"2103893",
"18824507",
"19038348",
"17302811"
] | [
"The structure of ClpP at 2.3 A resolution suggests a model for ATP-dependent proteolysis.",
"Sequence and structure of Clp P, the proteolytic component of the ATP-dependent Clp protease of Escherichia coli.",
"ClpP: a distinctive family of cylindrical energy-dependent serine proteases.",
"New insights into t... | [
1997,
1990,
2007,
1999,
1990,
2008,
2009,
2007
] | 8 | [
"IPR023562"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
34,
46552,
24496,
665,
1050
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
35,
1,
1,
3,
1,
3,
3,
1,
36,
2,
68
] | 11 | true | Family | ATP-dependent Clp protease proteolytic subunit | ATP-dependent Clp protease proteolytic subunit | ClpP | 6 |
IPR001908 | 1,908 | Melanocortin receptor 3-5 | MC3-5R | Family | 4,410 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0004977",
"GO:0007186",
"GO:0016020"
] | [
"melanocortin receptor activity",
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR00535"
] | [
"MELNOCORTINR"
] | [
4410
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-375276",
"R-BTA-418555",
"R-DRE-375276",
"R-HSA-375276",
"R-HSA-418555",
"R-HSA-9856649",
"R-MMU-375276",
"R-MMU-418555",
"R-RNO-375276",
"R-SSC-375276",
"R-SSC-418555"
] | [
"REACTOME:R-BTA-375276",
"REACTOME:R-BTA-418555",
"REACTOME:R-DRE-375276",
"REACTOME:R-HSA-375276",
"REACTOME:R-HSA-418555",
"REACTOME:R-HSA-9856649",
"REACTOME:R-MMU-375276",
"REACTOME:R-MMU-418555",
"REACTOME:R-RNO-375276",
"REACTOME:R-SSC-375276",
"REACTOME:R-SSC-418555"
] | 11 | [
"6w25",
"7aue",
"7f53",
"7f54",
"7f55",
"7f58",
"7piu",
"7piv",
"8inr",
"8ioc",
"8iod",
"8kig",
"8qj2",
"8w8w",
"8w8x",
"8w8y",
"8wky",
"8wkz",
"9k3f",
"9k3h",
"9k3k"
] | 21 | [
"PUB00000131",
"PUB00002477",
"PUB00004960",
"PUB00004961",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816",
"PUB00099937",
"PUB00099938",
"PUB00099939",
"PUB00099940",
"PUB00099941"
] | [
"2111655",
"2830256",
"8386361",
"8170923",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293",
"25163632",
"32248247",
"19036988",
"12646665",
"23869017"
] | [
"G proteins in signal transduction.",
"G protein involvement in receptor-effector coupling.",
"Design of a discriminating fingerprint for G-protein-coupled receptors.",
"Fingerprinting G-protein-coupled receptors.",
"The G protein-coupled receptor repertoires of human and mouse.",
"GCRDb: a G-protein-coup... | [
1990,
1988,
1993,
1994,
2003,
1994,
2005,
2009,
2006,
2013,
2014,
2020,
2008,
2003,
2013
] | 15 | [
"IPR001671"
] | [
"IPR000155",
"IPR000621",
"IPR002122"
] | 1 | 3 | 0 | [
"Vertebrata"
] | [
4410
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
11,
17,
5
] | 4 | true | Family | Melanocortin receptor 3-5 | Melanocortin receptor 3-5 | MC3-5R | 1 |
IPR001910 | 1,910 | Inosine/uridine-preferring nucleoside hydrolase domain | Inosine/uridine_hydrolase_dom | Domain | 37,646 | false | false | Inosine-uridine preferring nucleoside hydrolase ( ) (IU-nucleoside hydrolase or IUNH) is an enzyme first identified in protozoan [ ] that catalyses the hydrolysis of all of the commonly occuring purine and pyrimidine nucleosides into ribose and the associated base, but has a preference for inosine and uridine as substr... | [
"GO:0016799"
] | [
"hydrolase activity, hydrolyzing N-glycosyl compounds"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF01156"
] | [
"IU_nuc_hydro"
] | [
37646
] | 1 | [
"GP",
"GP",
"GP",
"GP"
] | [
"GenProp1369",
"GenProp1430",
"GenProp1465",
"GenProp1540"
] | [
"GP:GenProp1369",
"GP:GenProp1430",
"GP:GenProp1465",
"GP:GenProp1540"
] | 4 | [
"1ezr",
"1hoz",
"1hp0",
"1kic",
"1kie",
"1mas",
"1q8f",
"1r4f",
"1yoe",
"2c40",
"2ff1",
"2ff2",
"2mas",
"3b9g",
"3b9x",
"3epw",
"3epx",
"3fz0",
"3g5i",
"3mkm",
"3mkn",
"3t8i",
"3t8j",
"4i70",
"4i71",
"4i72",
"4i73",
"4i74",
"4i75",
"4kl0",
"4kpn",
"4kpo"... | 56 | [
"PUB00000434",
"PUB00000435"
] | [
"8634237",
"8634238"
] | [
"Inosine-uridine nucleoside hydrolase from Crithidia fasciculata. Genetic characterization, crystallization, and identification of histidine 241 as a catalytic site residue.",
"Three-dimensional structure of the inosine-uridine nucleoside N-ribohydrolase from Crithidia fasciculata."
] | [
1996,
1996
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
318,
25929,
11084,
7,
308
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",... | [
18,
2,
6,
4,
3,
3,
18,
1,
3,
63
] | 10 | true | Domain | Inosine/uridine-preferring nucleoside hydrolase domain | Inosine/uridine-preferring nucleoside hydrolase domain | Inosine/uridine_hydrolase_dom | 5 |
IPR001912 | 1,912 | Small ribosomal subunit protein uS4, N-terminal | Ribosomal_uS4_N | Domain | 61,517 | false | false | This entry represents the domain found at the N terminus of the small ribosomal subunit uS4. Small ribosomal subunit protein uS4 was previously known as Ribosomal protein S4 in bacteria and plants and S9 in fungi and animals. S4 is known to bind directly to 16S ribosomal RNA. The crystal structure of a bacterial S4 pro... | [
"GO:0019843"
] | [
"rRNA binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"SMART"
] | [
"PF00163",
"SM01390"
] | [
"Ribosomal_S4",
"Ribosomal_S4"
] | [
60740,
60099
] | 2 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00549",
"R-BTA-156827",
"R-BTA-1799339",
"R-BTA-6791226",
"R-BTA-72649",
"R-BTA-72689",
"R-BTA-72695",
"R-BTA-72702",
"R-BTA-72706",
"R-BTA-975956",
"R-BTA-975957",
"R-CEL-156827",
"R-CEL-1799339",
"R-CEL-6791226",
"R-CEL-72649",
"R-CEL-72689",
"R-CEL-72695",
"R-CEL-72702",
... | [
"PROSITEDOC:PDOC00549",
"REACTOME:R-BTA-156827",
"REACTOME:R-BTA-1799339",
"REACTOME:R-BTA-6791226",
"REACTOME:R-BTA-72649",
"REACTOME:R-BTA-72689",
"REACTOME:R-BTA-72695",
"REACTOME:R-BTA-72702",
"REACTOME:R-BTA-72706",
"REACTOME:R-BTA-975956",
"REACTOME:R-BTA-975957",
"REACTOME:R-CEL-156827"... | 99 | [
"1c05",
"1c06",
"1eg0",
"1fjg",
"1fka",
"1hnw",
"1hnx",
"1hnz",
"1hr0",
"1i94",
"1i95",
"1i96",
"1i97",
"1ibk",
"1ibl",
"1ibm",
"1j5e",
"1jgo",
"1jgp",
"1jgq",
"1ml5",
"1n32",
"1n33",
"1n34",
"1n36",
"1qd7",
"1vvj",
"1vy4",
"1vy5",
"1vy6",
"1vy7",
"1xmo"... | 1,812 | [
"PUB00001317",
"PUB00007068",
"PUB00007069",
"PUB00007070"
] | [
"9707415",
"11297922",
"11290319",
"11114498"
] | [
"The crystal structure of ribosomal protein S4 reveals a two-domain molecule with an extensive RNA-binding surface: one domain shows structural homology to the ETS DNA-binding motif.",
"Atomic structures at last: the ribosome in 2000.",
"The ribosome in focus.",
"The end of the beginning: structural studies o... | [
1998,
2001,
2001,
2000
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctNZc11",
"unclassified sequences"
] | [
882,
24964,
35168,
1,
502
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
16,
2,
2,
4,
1,
7,
7,
2,
14,
7,
3,
3,
26
] | 13 | true | Domain | Small ribosomal subunit protein uS4, N-terminal | Small ribosomal subunit protein uS4, N-terminal | Ribosomal_uS4_N | 9 |
IPR001913 | 1,913 | Equine arteritis virus GP2b envelope glycoprotein | Equi_arteri_GP2b | Family | 142 | false | false | Equine arteritis virus (EAV) is an enveloped, positive-strand RNA virus belonging to the family Arteriviridae. EAV virions contain six different envelope proteins. GP5 (previously named GL) and the unglycosylated membrane protein M are the major envelope proteins, while the glycoproteins GP2b (previously named Gs), GP3... | [
"GO:0019031"
] | [
"viral envelope"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF01309"
] | [
"EAV_GS"
] | [
142
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00003515",
"PUB00005632",
"PUB00076655"
] | [
"7745690",
"8938984",
"14645556"
] | [
"The small envelope glycoprotein (GS) of equine arteritis virus folds into three distinct monomers and a disulfide-linked dimer.",
"Comparison of nucleic and amino acid sequences and phylogenetic analysis of the Gs protein of various equine arteritis virus isolates.",
"Intra- and intermolecular disulfide bonds ... | [
1995,
1996,
2003
] | 3 | [] | [] | 0 | 0 | null | [
"Equine arteritis virus"
] | [
142
] | 1 | [] | [] | 0 | true | Family | Equine arteritis virus GP2b envelope glycoprotein | Equine arteritis virus GP2b envelope glycoprotein | Equi_arteri_GP2b | 8 |
IPR001915 | 1,915 | Peptidase M48 | Peptidase_M48 | Domain | 88,033 | false | false | This entry represents the largely extracellular catalytic region of CAAX prenyl protease homologues such as Human FACE-1 protease. These are metallopeptidases, with the characteristic HExxH motif giving the two histidine-zinc-ligands and an adjacent glutamate on the next helix being the third. The whole molecule folds ... | [
"GO:0004222",
"GO:0006508"
] | [
"metalloendopeptidase activity",
"proteolysis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF01435"
] | [
"Peptidase_M48"
] | [
88033
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.4.24.-",
"PWY-8119",
"R-BTA-169911",
"R-BTA-9840373",
"R-DRE-169911",
"R-DRE-9840373",
"R-HSA-169911",
"R-HSA-9837999",
"R-HSA-9840373",
"R-MMU-169911",
"R-MMU-9840373",
"R-RNO-169911",
"R-RNO-9840373",
"R-SCE-169911",
"R-SCE-9840373",
"R-SPO-169911",
"R-SPO-9840373"
] | [
"EC:3.4.24.-",
"METACYC:PWY-8119",
"REACTOME:R-BTA-169911",
"REACTOME:R-BTA-9840373",
"REACTOME:R-DRE-169911",
"REACTOME:R-DRE-9840373",
"REACTOME:R-HSA-169911",
"REACTOME:R-HSA-9837999",
"REACTOME:R-HSA-9840373",
"REACTOME:R-MMU-169911",
"REACTOME:R-MMU-9840373",
"REACTOME:R-RNO-169911",
"R... | 17 | [
"2ypt",
"3c37",
"3cqb",
"4aw6",
"4il3",
"5syt",
"6ait",
"6bh8",
"6sar"
] | 9 | [
"PUB00075616",
"PUB00075617"
] | [
"23539602",
"23539603"
] | [
"Structure of the integral membrane protein CAAX protease Ste24p.",
"The structural basis of ZMPSTE24-dependent laminopathies."
] | [
2013,
2013
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
2538,
72801,
11498,
16,
1180
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
17,
1,
3,
5,
4,
5,
3,
2,
9,
7,
2,
3,
41
] | 13 | true | Domain | Peptidase M48 | Peptidase M48 | Peptidase_M48 | 1 |
IPR001916 | 1,916 | Glycoside hydrolase, family 22 | Glyco_hydro_22 | Family | 5,996 | false | false | Glycoside hydrolase family 22 comprises enzymes with two known activities; lysozyme type C ( ) (also known as 1, 4-beta-N-acetylmuramidase or LYZ) and alpha-lactalbumins (also known as lactose synthase B protein or LA). Asp and/or the carbonyl oxygen of the C-2 acetamido group of the substrate acts as the catalytic nuc... | [] | [] | [] | 0 | [
"PFAM",
"PRINTS",
"PROFILE",
"PANTHER",
"SMART"
] | [
"PF00062",
"PR00135",
"PS51348",
"PTHR11407",
"SM00263"
] | [
"Lys",
"LYZLACT",
"GLYCOSYL_HYDROL_F22_2",
"",
"LYZ1"
] | [
5923,
5232,
5842,
5776,
5692
] | 5 | [
"CAZY",
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"GH22",
"3.2.1.17",
"PDOC00119",
"R-BTA-6798695",
"R-BTA-6803157",
"R-CFA-6798695",
"R-CFA-6803157",
"R-DME-5653890",
"R-GGA-5653890",
"R-GGA-6798695",
"R-GGA-6803157",
"R-HSA-5653890",
"R-HSA-6798695",
"R-HSA-6803157",
"R-HSA-977225",
"R-MMU-5653890",
"R-MMU-6798695",
"R-MMU-68031... | [
"CAZY:GH22",
"EC:3.2.1.17",
"PROSITEDOC:PDOC00119",
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-6803157",
"REACTOME:R-CFA-6798695",
"REACTOME:R-CFA-6803157",
"REACTOME:R-DME-5653890",
"REACTOME:R-GGA-5653890",
"REACTOME:R-GGA-6798695",
"REACTOME:R-GGA-6803157",
"REACTOME:R-HSA-5653890",
"REACT... | 23 | [
"132l",
"133l",
"134l",
"135l",
"193l",
"194l",
"1a2y",
"1a4v",
"1aki",
"1alc",
"1at5",
"1at6",
"1azf",
"1b0d",
"1b2k",
"1b5u",
"1b5v",
"1b5w",
"1b5x",
"1b5y",
"1b5z",
"1b7l",
"1b7m",
"1b7n",
"1b7o",
"1b7p",
"1b7q",
"1b7r",
"1b7s",
"1b9o",
"1bb3",
"1bb4"... | 1,616 | [
"PUB00001331",
"PUB00001375",
"PUB00001550",
"PUB00002334",
"PUB00002403",
"PUB00002496",
"PUB00003998",
"PUB00004870",
"PUB00005266",
"PUB00071536"
] | [
"3104032",
"2731545",
"3666156",
"3148618",
"6715332",
"2738070",
"3785375",
"7624375",
"8535779",
"12606493"
] | [
"Alpha-lactalbumin and related proteins: a versatile gene family with an interesting parentage.",
"The evolution of lysozyme and alpha-lactalbumin.",
"The calcium-binding property of equine lysozyme.",
"Amino acid sequence of a lysozyme (B-enzyme) from Bacillus subtilis YT-25.",
"Evolution of alpha-lactalbu... | [
1986,
1989,
1987,
1988,
1984,
1989,
1986,
1995,
1995,
2003
] | 10 | [] | [
"IPR000545",
"IPR000974"
] | 0 | 2 | 0 | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"viral metagenome"
] | [
13,
3,
5976,
4
] | 4 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
15,
22,
24,
23,
32
] | 5 | true | Family | Glycoside hydrolase, family 22 | Glycoside hydrolase, family 22 | Glyco_hydro_22 | 7 |
IPR001917 | 1,917 | Aminotransferase, class-II, pyridoxal-phosphate binding site | Aminotrans_II_pyridoxalP_BS | Binding_site | 70,013 | false | false | Aminotransferases share certain mechanistic features with other pyridoxal-phosphate dependent enzymes, such as the covalent binding of the pyridoxal-phosphate group to a lysine residue. On the basis of sequence similarity, these various enzymes can be grouped into subfamilies. One of these, is called class-II. It consi... | [
"GO:0016740"
] | [
"transferase activity"
] | [
"molecular_function"
] | 1 | [
"PROSITE"
] | [
"PS00599"
] | [
"AA_TRANSFER_CLASS_2"
] | [
70013
] | 1 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC00518",
"R-BTA-189451",
"R-DRE-189451",
"R-GGA-421984",
"R-HSA-1660661",
"R-HSA-189451",
"R-HSA-1989781",
"R-HSA-2151201",
"R-HSA-9837999",
"R-MMU-1660661",
"R-MMU-189451",
"R-MMU-9837999",
"R-RNO-1660661",
"R-RNO-189451",
"R-RNO-9837999",
"R-SCE-189451",
"R-SPO-189451"
] | [
"PROSITEDOC:PDOC00518",
"REACTOME:R-BTA-189451",
"REACTOME:R-DRE-189451",
"REACTOME:R-GGA-421984",
"REACTOME:R-HSA-1660661",
"REACTOME:R-HSA-189451",
"REACTOME:R-HSA-1989781",
"REACTOME:R-HSA-2151201",
"REACTOME:R-HSA-9837999",
"REACTOME:R-MMU-1660661",
"REACTOME:R-MMU-189451",
"REACTOME:R-MMU... | 17 | [
"1bs0",
"1dj9",
"1dje",
"1fc4",
"1fg3",
"1fg7",
"1gew",
"1gex",
"1gey",
"1h1c",
"1iji",
"1uu0",
"1uu1",
"1uu2",
"2bwn",
"2bwo",
"2bwp",
"2f8j",
"2g6w",
"2jg2",
"2jgt",
"2w8j",
"2w8t",
"2w8u",
"2w8v",
"2w8w",
"2x8u",
"2xbn",
"3a2b",
"3hdo",
"3tqx",
"3wy7"... | 119 | [
"PUB00007901"
] | [
"11518529"
] | [
"Crystal structure of histidinol phosphate aminotransferase (HisC) from Escherichia coli, and its covalent complex with pyridoxal-5'-phosphate and l-histidinol phosphate."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
891,
53478,
14861,
4,
779
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
13,
2,
8,
3,
3,
12,
18,
2,
4,
20,
3,
3,
16
] | 13 | true | Binding_site | Aminotransferase, class-II, pyridoxal-phosphate binding site | Aminotransferase, class-II, pyridoxal-phosphate binding site | Aminotrans_II_pyridoxalP_BS | 5 |
IPR001919 | 1,919 | Carbohydrate-binding type-2 domain | CBD2 | Domain | 27,537 | false | false | The microbial degradation of cellulose and xylans requires several types of enzyme such as endoglucanases (EC 3.2.1.4), cellobiohydrolases (EC 3.2.1.91) (exoglucanases), or xylanases (EC 3.2.1.8) [ ]. Structurally, cellulases and xylanases generally consist of a catalytic domain and a conserved region of ~100 amino aci... | [
"GO:0004553",
"GO:0030246",
"GO:0005975"
] | [
"hydrolase activity, hydrolyzing O-glycosyl compounds",
"carbohydrate binding",
"carbohydrate metabolic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF00553",
"PS51173",
"SM00637"
] | [
"CBM_2",
"CBM2",
"CBD_II"
] | [
25965,
26655,
27108
] | 3 | [
"EC",
"GP",
"PROSITEDOC"
] | [
"3.2.1",
"GenProp1522",
"PDOC00485"
] | [
"EC:3.2.1",
"GP:GenProp1522",
"PROSITEDOC:PDOC00485"
] | 3 | [
"1e5b",
"1e5c",
"1exg",
"1exh",
"1heh",
"1hej",
"1xbd",
"2cwr",
"2czn",
"2rtt",
"2xbd",
"3ndy",
"3ndz",
"5dhd",
"5dhe",
"6bt9",
"6f7e",
"6qfs"
] | 18 | [
"PUB00000421",
"PUB00003608",
"PUB00005068",
"PUB00032378",
"PUB00033740"
] | [
"7766609",
"1886523",
"1812490",
"10425686",
"9662439"
] | [
"Solution structure of a cellulose-binding domain from Cellulomonas fimi by nuclear magnetic resonance spectroscopy.",
"Domains in microbial beta-1, 4-glycanases: sequence conservation, function, and enzyme families.",
"Bacterial cellulose-binding domain-like sequences in eucaryotic polypeptides.",
"A family ... | [
1995,
1991,
1991,
1999,
1998
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Megaviricetes",
"Thermococcaceae",
"unclassified sequences"
] | [
27033,
431,
21,
10,
42
] | 5 | [] | [] | 0 | true | Domain | Carbohydrate-binding type-2 domain | Carbohydrate-binding type-2 domain | CBD2 | 5 |
IPR001920 | 1,920 | Asp/Glu racemase | Asp/Glu_race | Homologous_superfamily | 43,708 | false | false | Aspartate racemase ( ) and glutamate racemase ( ) are two evolutionary related bacterial enzymes that do not seem to require a cofactor for their activity [ ]. Glutamate racemase catalyses the interconversion of d-and l-glutamic acid and is the source of d-glutamate in most bacterial strains. d-Glutamic acid is an impo... | [
"GO:0016855"
] | [
"racemase and epimerase activity, acting on amino acids and derivatives"
] | [
"molecular_function"
] | 1 | [
"CATHGENE3D",
"SSF"
] | [
"G3DSA:3.40.50.1860",
"SSF53681"
] | [
"",
""
] | [
42670,
42171
] | 2 | [
"EC",
"METACYC",
"METACYC",
"PROSITEDOC"
] | [
"5.1.1.3",
"PWY-6386",
"PWY-6387",
"PDOC00714"
] | [
"EC:5.1.1.3",
"METACYC:PWY-6386",
"METACYC:PWY-6387",
"PROSITEDOC:PDOC00714"
] | 4 | [
"1b73",
"1b74",
"1iu9",
"1jfl",
"1zuw",
"2dgd",
"2dwu",
"2dx7",
"2eq5",
"2gzm",
"2jfn",
"2jfo",
"2jfp",
"2jfq",
"2jfu",
"2jfv",
"2jfw",
"2jfx",
"2jfy",
"2jfz",
"2ohg",
"2oho",
"2ohv",
"2vvt",
"2w4i",
"2zsk",
"3hfr",
"3ist",
"3isv",
"3ojc",
"3out",
"3s7z"... | 60 | [
"PUB00000380",
"PUB00023532",
"PUB00083403",
"PUB00083404"
] | [
"8385993",
"10331867",
"10194325",
"11371180"
] | [
"Purification, cloning, and cofactor independence of glutamate racemase from Lactobacillus.",
"Structure and mechanism of glutamate racemase from Aquifex pyrophilus.",
"Catalytic acid/base residues of glutamate racemase.",
"Active site residues of glutamate racemase."
] | [
1993,
1999,
1999,
2001
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
340,
40811,
1813,
2,
742
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
5,
3,
3,
1,
6
] | 5 | true | Homologous_superfamily | Asp/Glu racemase | Asp/Glu racemase | Asp/Glu_race | 2 |
IPR001921 | 1,921 | Large ribosomal subunit protein eL8, eukaryota | Ribosomal_eL8_euk | Family | 7,032 | false | false | This family includes the large ribosomal subunit protein eL8 from human, which was formerly known as L7a, and its homologues [ , ]. The human gene resembles other mammalian ribosomal protein genes so far, as it contains a short first exon, a short 5' untranslated leader and its transcriptional start sites at C residues... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR00882"
] | [
"RIBOSOMALL7A"
] | [
7032
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-156827",
"R-BTA-1799339",
"R-BTA-6791226",
"R-BTA-72689",
"R-BTA-72706",
"R-BTA-975956",
"R-BTA-975957",
"R-CEL-156827",
"R-CEL-1799339",
"R-CEL-72689",
"R-CEL-72706",
"R-CEL-975956",
"R-CEL-975957",
"R-DDI-156827",
"R-DDI-1799339",
"R-DDI-72689",
"R-DDI-72706",
"R-DDI-97595... | [
"REACTOME:R-BTA-156827",
"REACTOME:R-BTA-1799339",
"REACTOME:R-BTA-6791226",
"REACTOME:R-BTA-72689",
"REACTOME:R-BTA-72706",
"REACTOME:R-BTA-975956",
"REACTOME:R-BTA-975957",
"REACTOME:R-CEL-156827",
"REACTOME:R-CEL-1799339",
"REACTOME:R-CEL-72689",
"REACTOME:R-CEL-72706",
"REACTOME:R-CEL-9759... | 64 | [
"3j6x",
"3j6y",
"3j77",
"3j78",
"3j79",
"3j7o",
"3j7p",
"3j7q",
"3j7r",
"3j92",
"3jag",
"3jah",
"3jai",
"3jaj",
"3jan",
"3jbn",
"3jbo",
"3jbp",
"3jcs",
"3jct",
"4d5y",
"4d67",
"4u3m",
"4u3n",
"4u3u",
"4u4n",
"4u4o",
"4u4q",
"4u4r",
"4u4u",
"4u4y",
"4u4z"... | 586 | [
"PUB00000574",
"PUB00003742",
"PUB00004372",
"PUB00005644",
"PUB00007068",
"PUB00007069",
"PUB00007070",
"PUB00101554"
] | [
"1756182",
"2046660",
"2183194",
"2063628",
"11297922",
"11290319",
"11114498",
"32669547"
] | [
"The organization and expression of the human L7a ribosomal protein gene.",
"The organization and expression of the Saccharomyces cerevisiae L4 ribosomal protein genes and their identification as the homologues of the mammalian ribosomal protein gene L7a.",
"Ribosomal protein L4 of Saccharomyces cerevisiae: the... | [
1991,
1991,
1990,
1991,
2001,
2001,
2000,
2020
] | 8 | [
"IPR018492"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Natronococcus pandeyae"
] | [
4,
7027,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
8,
1,
1,
2,
4,
6,
1,
6,
33,
2,
1,
14
] | 12 | true | Family | Large ribosomal subunit protein eL8, eukaryota | Large ribosomal subunit protein eL8, eukaryota | Ribosomal_eL8_euk | 8 |
IPR001922 | 1,922 | Dopamine D2 receptor | Dopamine_D2_rcpt | Family | 1,126 | false | false | Dopamine receptors are members of the rhodopsin-like G-protein coupled receptor family and are prominent in the vertebrate central nervous system (CNS). Dysfunction of dopaminergic neurotransmission in the CNS has been implicated in a variety of neuropsychiatric disorders [ ], including social phobia [ ], Tourette's sy... | [
"GO:0004952",
"GO:0007195",
"GO:0016020"
] | [
"dopamine neurotransmitter receptor activity",
"adenylate cyclase-inhibiting dopamine receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR00567"
] | [
"DOPAMINED2R"
] | [
1126
] | 1 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"215",
"R-HSA-390651",
"R-MMU-390651",
"R-RNO-390651"
] | [
"IUPHAR:215",
"REACTOME:R-HSA-390651",
"REACTOME:R-MMU-390651",
"REACTOME:R-RNO-390651"
] | 4 | [
"7jvr",
"8irs",
"8tzq",
"8u02",
"9bs9",
"9bsb"
] | 6 | [
"PUB00064281",
"PUB00064282",
"PUB00064283",
"PUB00064284",
"PUB00064285",
"PUB00064286",
"PUB00064287",
"PUB00064288",
"PUB00064289",
"PUB00064290",
"PUB00064291",
"PUB00064292",
"PUB00064293",
"PUB00064301",
"PUB00067001",
"PUB00067006",
"PUB00067007",
"PUB00067008"
] | [
"15148138",
"10698826",
"16613557",
"17017512",
"12555236",
"16961425",
"11920678",
"9633679",
"16433053",
"14060771",
"1060115",
"12836695",
"9457173",
"16968475",
"16458973",
"15671878",
"9169514",
"11303741"
] | [
"The neurobiology of dopamine signaling.",
"Low dopamine D(2) receptor binding potential in social phobia.",
"Dopamine and the diseased brain.",
"The nigrostriatal DA pathway and Parkinson's disease.",
"Relationship between functional dopamine D2 and D3 receptors gene polymorphisms and neuroleptic malignant... | [
2004,
2000,
2006,
2006,
2003,
2006,
2002,
1998,
2005,
1963,
1975,
2003,
1998,
2006,
2006,
2005,
1997,
2001
] | 18 | [
"IPR000929"
] | [] | 1 | 0 | 1 | [
"Vertebrata"
] | [
1126
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
10,
4,
1,
3
] | 4 | true | Family | Dopamine D2 receptor | Dopamine D2 receptor | Dopamine_D2_rcpt | 3 |
IPR001925 | 1,925 | Porin, eukaryotic type | Porin_Euk | Family | 12,673 | false | false | Eukaryotic mitochondrial porins are voltage-dependent anion-selective channels (VDAC) that behave as general diffusion pores for small hydrophilic molecules [ , , , ]. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The proteins are compo... | [
"GO:0008308",
"GO:0098656",
"GO:0005741"
] | [
"voltage-gated monoatomic anion channel activity",
"monoatomic anion transmembrane transport",
"mitochondrial outer membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS",
"PROSITE",
"PANTHER",
"CDD"
] | [
"PR00185",
"PS00558",
"PTHR11743",
"cd07306"
] | [
"EUKARYTPORIN",
"EUKARYOTIC_PORIN",
"",
"Porin3_VDAC"
] | [
7008,
5291,
12531,
11350
] | 4 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00483",
"R-BTA-5205685",
"R-BTA-5689880",
"R-BTA-70268",
"R-CEL-5205685",
"R-CEL-5689880",
"R-CEL-70268",
"R-DDI-5205685",
"R-DDI-70268",
"R-DME-5205685",
"R-DME-5689880",
"R-DME-70268",
"R-HSA-1268020",
"R-HSA-5205685",
"R-HSA-5689880",
"R-HSA-70268",
"R-HSA-8949215",
"R-MMU-... | [
"PROSITEDOC:PDOC00483",
"REACTOME:R-BTA-5205685",
"REACTOME:R-BTA-5689880",
"REACTOME:R-BTA-70268",
"REACTOME:R-CEL-5205685",
"REACTOME:R-CEL-5689880",
"REACTOME:R-CEL-70268",
"REACTOME:R-DDI-5205685",
"REACTOME:R-DDI-70268",
"REACTOME:R-DME-5205685",
"REACTOME:R-DME-5689880",
"REACTOME:R-DME-... | 31 | [
"2jk4",
"2k4t",
"3emn",
"4bum",
"4c69",
"5jdp",
"5xdn",
"5xdo",
"6g6u",
"6g73",
"6tiq",
"6tir",
"7kuh",
"7nie",
"7qi2",
"7tcv",
"8j0o",
"9eih",
"9eii",
"9eij",
"9gng",
"9jvq"
] | 22 | [
"PUB00000661",
"PUB00001485",
"PUB00001974",
"PUB00002365",
"PUB00005391",
"PUB00072140",
"PUB00158948"
] | [
"8031826",
"1689252",
"8812436",
"2442148",
"1384178",
"22020053",
"31015432"
] | [
"Permeation of hydrophilic solutes through mitochondrial outer membranes: review on mitochondrial porins.",
"The biogenesis and function of eukaryotic porins.",
"A novel mouse mitochondrial voltage-dependent anion channel gene localizes to chromosome 8.",
"Molecular genetics of the VDAC ion channel: structura... | [
1994,
1990,
1996,
1987,
1992,
2012,
2019
] | 7 | [
"IPR027246"
] | [] | 1 | 0 | 1 | [
"Actinomycetes",
"Eukaryota",
"bird metagenome"
] | [
2,
12670,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
25,
1,
13,
8,
18,
15,
1,
11,
14,
2,
1,
52
] | 12 | true | Family | Porin, eukaryotic type | Porin, eukaryotic type | Porin_Euk | 8 |
IPR001926 | 1,926 | Tryptophan synthase beta chain-like, PALP domain | TrpB-like_PALP | Domain | 236,235 | false | false | This entry represents a domain found in a group of proteins of the PLP-dependent enzymes superfamily represented by the beta subunit of tryptophan synthase (TrpB) [ ]. This group of diverse proteins also include threonine dehydratase, cysteine synthase, threonine synthase and pyridoxal phosphate-dependent deaminase. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF00291"
] | [
"PALP"
] | [
236235
] | 1 | [
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"GenProp1223",
"GenProp1274",
"R-BTA-977347",
"R-CEL-1614603",
"R-DDI-1614603",
"R-DDI-8849175",
"R-DDI-977347",
"R-HSA-1614603",
"R-HSA-2408508",
"R-HSA-8849175",
"R-HSA-977347",
"R-MMU-1614603",
"R-MMU-8849175",
"R-MMU-977347",
"R-MTU-936654",
"R-MTU-936721",
"R-RNO-1614603",
"R-... | [
"GP:GenProp1223",
"GP:GenProp1274",
"REACTOME:R-BTA-977347",
"REACTOME:R-CEL-1614603",
"REACTOME:R-DDI-1614603",
"REACTOME:R-DDI-8849175",
"REACTOME:R-DDI-977347",
"REACTOME:R-HSA-1614603",
"REACTOME:R-HSA-2408508",
"REACTOME:R-HSA-8849175",
"REACTOME:R-HSA-977347",
"REACTOME:R-MMU-1614603",
... | 23 | [
"1a50",
"1a5a",
"1a5b",
"1a5s",
"1beu",
"1bks",
"1c29",
"1c8v",
"1c9d",
"1cw2",
"1cx9",
"1d6s",
"1e5x",
"1f2d",
"1fcj",
"1fuy",
"1j0a",
"1j0b",
"1j0c",
"1j0d",
"1j0e",
"1jbq",
"1k3u",
"1k7e",
"1k7f",
"1k7x",
"1k8x",
"1k8y",
"1k8z",
"1kfb",
"1kfc",
"1kfe"... | 443 | [
"PUB00070977"
] | [
"10673430"
] | [
"The manifold of vitamin B6 dependent enzymes."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
5972,
180925,
45577,
31,
3730
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
94,
13,
12,
3,
9,
22,
14,
11,
59,
21,
9,
7,
125
] | 13 | true | Domain | Tryptophan synthase beta chain-like, PALP domain | Tryptophan synthase beta chain-like, PALP domain | TrpB-like_PALP | 6 |
IPR001927 | 1,927 | Sodium:galactoside symporter | Na/Gal_symport | Domain | 17,094 | false | false | It has been shown [ ] that integral membrane proteins that mediate the intake of a wide variety of molecules with the concomitant uptake of sodium ions (sodium symporters) can be grouped, on the basis of sequence and functional similarities into a number of distinct families. This collection of sequences represents the... | [
"GO:0006814",
"GO:0016020"
] | [
"sodium ion transport",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00792"
] | [
"gph"
] | [
17094
] | 1 | [
"PROSITEDOC"
] | [
"PDOC00680"
] | [
"PROSITEDOC:PDOC00680"
] | 1 | [
"4m64",
"7l16",
"7l17",
"8fq9",
"8frh",
"8t60"
] | 6 | [
"PUB00000660"
] | [
"8031825"
] | [
"A functional superfamily of sodium/solute symporters."
] | [
1994
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
17037,
10,
1,
46
] | 4 | [
"Escherichia coli (strain K12)"
] | [
7
] | 1 | true | Domain | Sodium:galactoside symporter | Sodium:galactoside symporter | Na/Gal_symport | 2 |
IPR001928 | 1,928 | Endothelin-like toxin | Endothln-like_toxin | Domain | 2,957 | false | false | Endothelins (ET's) are the most potent vasoconstrictors known [ , , ]. They stimulate cardiac contraction, regulate release of vasoactive substances, and stimulate mitogenesis in blood vessels in primary culture. They also stimulate contraction in almost all other smooth muscles (e.g., uterus, bronchus, vas deferensa a... | [
"GO:0019229",
"GO:0005576"
] | [
"regulation of vasoconstriction",
"extracellular region"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"SMART"
] | [
"PF00322",
"SM00272"
] | [
"Endothelin",
"END"
] | [
2908,
2946
] | 2 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC00243",
"R-BTA-375276",
"R-BTA-416476",
"R-CFA-375276",
"R-CFA-416476",
"R-HSA-375276",
"R-HSA-416476",
"R-HSA-9856649",
"R-MMU-375276",
"R-MMU-416476",
"R-RNO-375276",
"R-RNO-416476",
"R-SSC-375276",
"R-SSC-416476"
] | [
"PROSITEDOC:PDOC00243",
"REACTOME:R-BTA-375276",
"REACTOME:R-BTA-416476",
"REACTOME:R-CFA-375276",
"REACTOME:R-CFA-416476",
"REACTOME:R-HSA-375276",
"REACTOME:R-HSA-416476",
"REACTOME:R-HSA-9856649",
"REACTOME:R-MMU-375276",
"REACTOME:R-MMU-416476",
"REACTOME:R-RNO-375276",
"REACTOME:R-RNO-416... | 14 | [
"1edn",
"1edp",
"1srb",
"1t7h",
"1v6r",
"2lde",
"2ldf",
"3cmh",
"5glh",
"6cmh",
"6dk5",
"6igk",
"6igl",
"6lry",
"8hbd",
"8hcq",
"8hcx",
"8iy5",
"8iy6",
"8xgr",
"8xve",
"8xvh",
"8xvi",
"8xwp",
"8xwq",
"8zrt"
] | 26 | [
"PUB00001506",
"PUB00001510",
"PUB00005372",
"PUB00005552",
"PUB00005553"
] | [
"2168326",
"1916094",
"1656557",
"2549664",
"2690429"
] | [
"Cellular signaling by peptides of the endothelin gene family.",
"Endothelins.",
"Endothelins and sarafotoxins: physiological regulation, receptor subtypes and transmembrane signaling.",
"Similarities in mode and sites of action of sarafotoxins and endothelins.",
"Molecular biology and biochemistry of the e... | [
1990,
1991,
1991,
1989,
1989
] | 5 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Bilateria",
"Chordopoxvirinae"
] | [
2,
2952,
3
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
8,
6,
9
] | 4 | true | Domain | Endothelin-like toxin | Endothelin-like toxin | Endothln-like_toxin | 1 |
IPR001932 | 1,932 | PPM-type phosphatase-like domain | PPM-type_phosphatase-like_dom | Domain | 234,626 | false | false | Protein phosphatases remove phosphate groups from various proteins that are the key components of a number of signalling pathways in eukaryotes and prokaryotes. Protein phosphatases that dephosphorylate Ser and Thr residues are classified into the phosphoprotein (PPP) and the protein phosphatase Mg2- or Mn2-dependent (... | [] | [] | [] | 0 | [
"PFAM",
"PFAM",
"PFAM",
"PROFILE",
"SMART",
"SMART",
"CDD"
] | [
"PF00481",
"PF07228",
"PF13672",
"PS51746",
"SM00331",
"SM00332",
"cd00143"
] | [
"PP2C",
"SpoIIE",
"PP2C_2",
"PPM_2",
"PP2C_SIG",
"PP2Cc",
"PP2Cc"
] | [
104387,
85290,
37744,
149655,
132803,
137910,
126810
] | 7 | [
"EC",
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"3.1.3",
"3.1.3.16",
"R-BTA-1169408",
"R-BTA-204174",
"R-BTA-2173795",
"R-BTA-380972",
"R-BTA-70895",
"R-CEL-1169408",
"R-CEL-2173795",
"R-CEL-380972",
"R-DME-199418",
"R-DME-6803207",
"R-HSA-1169408",
"R-HSA-1660661",
"R-HSA-168638",
"R-HSA-199418",
"R-HSA-204174",
"R-HSA-2173795"... | [
"EC:3.1.3",
"EC:3.1.3.16",
"REACTOME:R-BTA-1169408",
"REACTOME:R-BTA-204174",
"REACTOME:R-BTA-2173795",
"REACTOME:R-BTA-380972",
"REACTOME:R-BTA-70895",
"REACTOME:R-CEL-1169408",
"REACTOME:R-CEL-2173795",
"REACTOME:R-CEL-380972",
"REACTOME:R-DME-199418",
"REACTOME:R-DME-6803207",
"REACTOME:R... | 66 | [
"1a6q",
"1txo",
"2cm1",
"2i0o",
"2i44",
"2iq1",
"2irm",
"2isn",
"2j4o",
"2j82",
"2j86",
"2jfr",
"2jfs",
"2jft",
"2p8e",
"2pk0",
"2pnq",
"2pom",
"2pop",
"2v06",
"2xzv",
"2y09",
"3d8k",
"3eq2",
"3es2",
"3f79",
"3f7a",
"3fxj",
"3fxk",
"3fxl",
"3fxm",
"3fxo"... | 128 | [
"PUB00001297",
"PUB00056982",
"PUB00074808",
"PUB00074809",
"PUB00101158"
] | [
"9003755",
"22115775",
"9869399",
"22668558",
"24518043"
] | [
"Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution.",
"Structure of the Phosphatase Domain of the Cell Fate Determinant SpoIIE from Bacillus subtilis.",
"Protein phosphatase 2C (PP2C) function in higher plants.",
"Function analysis of conserved amino acid residues in a Mn(2+... | [
1996,
2011,
1998,
2012,
2014
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
354,
120383,
112739,
96,
1054
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
350,
13,
57,
35,
1,
83,
56,
8,
200,
82,
8,
7,
810
] | 13 | true | Domain | PPM-type phosphatase-like domain | PPM-type phosphatase-like domain | PPM-type_phosphatase-like_dom | 9 |
IPR001933 | 1,933 | Neuropeptide Y4 receptor | NPY4_rcpt | Family | 659 | false | false | Neuropeptide Y (NPY) acts as a neurotransmitter in the brain and in the autonomic nervous system. In the brain it is thought to have several functions, including increasing food intake and storage of energy as fat [ , , , ], facilitation of learning and memory via the modulation of hippocampal activity [ , , ], inhibit... | [
"GO:0004983",
"GO:0007186",
"GO:0016020"
] | [
"neuropeptide Y receptor activity",
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01015"
] | [
"NRPEPTIDEY4R"
] | [
659
] | 1 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"307",
"R-HSA-375276",
"R-HSA-418594",
"R-MMU-375276",
"R-MMU-418594",
"R-RNO-375276",
"R-RNO-418594"
] | [
"IUPHAR:307",
"REACTOME:R-HSA-375276",
"REACTOME:R-HSA-418594",
"REACTOME:R-MMU-375276",
"REACTOME:R-MMU-418594",
"REACTOME:R-RNO-375276",
"REACTOME:R-RNO-418594"
] | 7 | [
"7x9c"
] | 1 | [
"PUB00002930",
"PUB00063739",
"PUB00063740",
"PUB00063741",
"PUB00063742",
"PUB00063743",
"PUB00063744",
"PUB00063745",
"PUB00063746",
"PUB00063747",
"PUB00063748",
"PUB00063749",
"PUB00063750",
"PUB00063751",
"PUB00063752",
"PUB00063753",
"PUB00063754",
"PUB00063755",
"PUB000637... | [
"7592911",
"6549409",
"16874931",
"6547387",
"6549039",
"2821236",
"8395947",
"16190896",
"7529442",
"7644568",
"15337373",
"8685245",
"8369959",
"11287113",
"7629398",
"6133408",
"3855566",
"12678499",
"17222466",
"8013354",
"9833945",
"9389418",
"9446690",
"2453065",
... | [
"Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.",
"Neuropeptide Y: a potent inducer of consummatory behavior in rats.",
"Neuropeptide Y in normal eating and in genetic and dietary-induced obesity.",
"Neuropeptide Y and human pancrea... | [
1995,
1984,
2006,
1984,
1984,
1987,
1993,
2005,
1994,
1995,
2004,
1996,
1993,
2001,
1995,
1982,
1985,
2003,
2007,
1994,
1998,
1997,
1998,
1988,
1991,
1995,
2003,
2007,
1998,
2004,
2007,
2007,
2007,
2006,
2007,
2006,
2007,
2008,
1996,
1996... | 42 | [
"IPR000611"
] | [] | 1 | 0 | 1 | [
"Vertebrata"
] | [
659
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
2,
2
] | 4 | true | Family | Neuropeptide Y4 receptor | Neuropeptide Y4 receptor | NPY4_rcpt | 2 |
IPR001936 | 1,936 | Ras GTPase-activating domain | RasGAP_dom | Domain | 35,943 | false | false | This entry represents a conserved domain in the RasGAPs (Ras GTPase-activating proteins). This domain is also known as the RasGAP domain. Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP [ ]. This intrinsic GTPase activity of Ras is regulated by a family of p... | [
"GO:0043087"
] | [
"regulation of GTPase activity"
] | [
"biological_process"
] | 1 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF00616",
"PS50018",
"SM00323"
] | [
"RasGAP",
"RAS_GTPASE_ACTIV_2",
"RasGAP"
] | [
34566,
35799,
31427
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00438",
"R-BTA-8856828",
"R-BTA-8876198",
"R-CEL-8856828",
"R-CEL-8876198",
"R-DDI-5626467",
"R-DDI-5658442",
"R-DDI-6798695",
"R-DDI-9013149",
"R-DDI-9013404",
"R-DDI-9013406",
"R-DDI-9013408",
"R-DDI-9013420",
"R-DDI-9013424",
"R-DME-5658442",
"R-DME-8856828",
"R-DME-8876198",... | [
"PROSITEDOC:PDOC00438",
"REACTOME:R-BTA-8856828",
"REACTOME:R-BTA-8876198",
"REACTOME:R-CEL-8856828",
"REACTOME:R-CEL-8876198",
"REACTOME:R-DDI-5626467",
"REACTOME:R-DDI-5658442",
"REACTOME:R-DDI-6798695",
"REACTOME:R-DDI-9013149",
"REACTOME:R-DDI-9013404",
"REACTOME:R-DDI-9013406",
"REACTOME:... | 88 | [
"1nf1",
"1wer",
"1wq1",
"3bxj",
"3fay",
"5cjp",
"6ob2",
"6ob3",
"6v65",
"6v6f",
"7moc",
"7mp5",
"7mp6",
"7pgp",
"7pgq",
"7pgr",
"7pgs",
"7pgt",
"7pgu",
"7r03",
"7r04",
"8bos",
"8e20",
"8edl",
"8edm",
"8edn",
"8edo",
"8eoz",
"9bz4"
] | 29 | [
"PUB00000726",
"PUB00000983",
"PUB00004087",
"PUB00004162"
] | [
"7945277",
"1883874",
"1898771",
"8259209"
] | [
"Regulation of the Ras signalling network.",
"sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1.",
"The GTPase superfamily: conserved structure and molecular mechanism.",
"Proteins regulating Ras and its relatives."
] | [
1994,
1991,
1991,
1993
] | 4 | [] | [
"IPR037776"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Halopenitus persicus",
"Marseillevirus LCMAC101",
"ecological metagenomes"
] | [
48,
35891,
1,
1,
2
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
5,
151,
22,
72,
55,
4,
83,
4,
2
] | 9 | true | Domain | Ras GTPase-activating domain | Ras GTPase-activating domain | RasGAP_dom | 2 |
IPR001937 | 1,937 | Galactose-1-phosphate uridyl transferase, class I | GalP_UDPtransf1 | Family | 14,240 | false | false | Galactose-1-phosphate uridyl transferase (GalT) catalyses the transfer of an uridyldiphosphate group on galactose (or glucose) 1-phosphate. During the reaction, the uridyl moiety links to a histidine residue. In the Escherichia coli enzyme, it has been shown [ ] that two histidine residues separated by a single proline... | [
"GO:0008108",
"GO:0008270",
"GO:0006012"
] | [
"UDP-glucose:hexose-1-phosphate uridylyltransferase activity",
"zinc ion binding",
"galactose metabolic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PIRSF",
"PANTHER",
"NCBIFAM",
"CDD"
] | [
"PIRSF000808",
"PTHR11943",
"TIGR00209",
"cd00608"
] | [
"GalT",
"",
"galT_1",
"GalT"
] | [
12808,
12079,
12520,
7747
] | 4 | [
"EC",
"GP",
"GP",
"GP",
"METACYC",
"METACYC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.7.12",
"GenProp0143",
"GenProp1310",
"GenProp1661",
"PWY-6317",
"PWY-6527",
"PDOC00108",
"R-CEL-70370",
"R-DME-70370",
"R-HSA-5609978",
"R-HSA-70370",
"R-MMU-70370",
"R-RNO-70370"
] | [
"EC:2.7.7.12",
"GP:GenProp0143",
"GP:GenProp1310",
"GP:GenProp1661",
"METACYC:PWY-6317",
"METACYC:PWY-6527",
"PROSITEDOC:PDOC00108",
"REACTOME:R-CEL-70370",
"REACTOME:R-DME-70370",
"REACTOME:R-HSA-5609978",
"REACTOME:R-HSA-70370",
"REACTOME:R-MMU-70370",
"REACTOME:R-RNO-70370"
] | 13 | [
"1gup",
"1guq",
"1hxp",
"1hxq",
"1z84",
"1zwj",
"2h39",
"2q4h",
"2q4l",
"4qvu",
"5in3",
"6gqd",
"6k5z",
"6k9z"
] | 14 | [
"PUB00002146",
"PUB00004352"
] | [
"2066342",
"2845364"
] | [
"Galactose utilization in Lactobacillus helveticus: isolation and characterization of the galactokinase (galK) and galactose-1-phosphate uridyl transferase (galT) genes.",
"Conservation of short patches of amino acid sequence amongst proteins with a common function but evolutionarily distinct origins: implication... | [
1991,
1988
] | 2 | [] | [
"IPR012361",
"IPR043576"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
239,
9528,
4205,
268
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
4,
1,
4,
2,
1,
28,
9,
1,
1,
4,
1,
1,
4
] | 13 | true | Family | Galactose-1-phosphate uridyl transferase, class I | Galactose-1-phosphate uridyl transferase, class I | GalP_UDPtransf1 | 5 |
IPR001938 | 1,938 | Thaumatin family | Thaumatin | Family | 21,535 | false | false | Thaumatin [ ] is an intensely sweet-tasting protein, 100 000 times sweeter than sucrose on a molar basis [ ], found in berries from Thaumatococcus daniellii, a tropical flowering plant known as Katemfe. It is induced by attack by viroids, which are single-stranded unencapsulated RNA molecules that do not code for prote... | [] | [] | [] | 0 | [
"PFAM",
"PIRSF",
"PRINTS",
"PROFILE",
"PANTHER",
"SMART"
] | [
"PF00314",
"PIRSF002703",
"PR00347",
"PS51367",
"PTHR31048",
"SM00205"
] | [
"Thaumatin",
"Thaumatin",
"THAUMATIN",
"THAUMATIN_2",
"",
"THN"
] | [
20323,
14005,
16847,
20903,
17892,
20587
] | 6 | [
"PROSITEDOC"
] | [
"PDOC00286"
] | [
"PROSITEDOC:PDOC00286"
] | 1 | [
"1aun",
"1du5",
"1lr2",
"1lr3",
"1lxz",
"1ly0",
"1pcv",
"1pp3",
"1rqw",
"1thi",
"1thu",
"1thv",
"1thw",
"1z3q",
"2a7i",
"2ahn",
"2blr",
"2blu",
"2d8o",
"2d8p",
"2g4y",
"2i0w",
"2oqn",
"2pe7",
"2vhk",
"2vhr",
"2vi1",
"2vi2",
"2vi3",
"2vi4",
"2vu6",
"2vu7"... | 215 | [
"PUB00001747",
"PUB00004543",
"PUB00004556",
"PUB00004580",
"PUB00004582",
"PUB00043682",
"PUB00088725"
] | [
"7049841",
"1650615",
"1463856",
"7846159",
"7630973",
"16666857",
"8637920"
] | [
"Cloning of cDNA encoding the sweet-tasting plant protein thaumatin and its expression in Escherichia coli.",
"A wheat glutathione-S-transferase gene with transposon-like sequences in the promoter region.",
"Nucleotide sequence of an osmotin-like cDNA induced in tomato during viroid infection.",
"Characteriza... | [
1982,
1991,
1992,
1994,
1995,
1989,
1996
] | 7 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
454,
21048,
29,
4
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
136,
5,
1,
142,
163
] | 5 | true | Family | Thaumatin family | Thaumatin family | Thaumatin | 8 |
IPR001940 | 1,940 | Peptidase S1C | Peptidase_S1C | Family | 86,468 | false | false | This group of serine peptidases and non-peptidase homologues belong to the MEROPS peptidase family S1, subfamily S1C (protease Do subfamily, clan PS(S)). A type example is the protease Do from Escherichia coli. This entry also includes the membrane transporter protein MamO and the magnetosome formation protease MamE. M... | [
"GO:0004252",
"GO:0006508"
] | [
"serine-type endopeptidase activity",
"proteolysis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PRINTS"
] | [
"PR00834"
] | [
"PROTEASES2C"
] | [
86468
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.4.21",
"R-BTA-9837999",
"R-DME-9837999",
"R-HSA-1474228",
"R-HSA-9760173",
"R-HSA-9837999",
"R-HSA-9841251",
"R-MMU-1474228",
"R-MMU-9837999",
"R-RNO-1474228"
] | [
"EC:3.4.21",
"REACTOME:R-BTA-9837999",
"REACTOME:R-DME-9837999",
"REACTOME:R-HSA-1474228",
"REACTOME:R-HSA-9760173",
"REACTOME:R-HSA-9837999",
"REACTOME:R-HSA-9841251",
"REACTOME:R-MMU-1474228",
"REACTOME:R-MMU-9837999",
"REACTOME:R-RNO-1474228"
] | 10 | [
"1ky9",
"1l1j",
"1lcy",
"1sot",
"1soz",
"1te0",
"1vcw",
"1y8t",
"2qf0",
"2qf3",
"2qgr",
"2r3u",
"2r3y",
"2rce",
"2z9i",
"2zle",
"3b8j",
"3cs0",
"3gcn",
"3gco",
"3gds",
"3gdu",
"3gdv",
"3k6y",
"3k6z",
"3lgi",
"3lgt",
"3lgu",
"3lgv",
"3lgw",
"3lgy",
"3lh1"... | 137 | [
"PUB00002101",
"PUB00002289",
"PUB00004344",
"PUB00009824",
"PUB00093597",
"PUB00093599"
] | [
"2180903",
"8576051",
"3057437",
"12408815",
"26981620",
"21414040"
] | [
"The HtrA (DegP) protein, essential for Escherichia coli survival at high temperatures, is an endopeptidase.",
"Characterization of degQ and degS, Escherichia coli genes encoding homologs of the DegP protease.",
"Sequence analysis and regulation of the htrA gene of Escherichia coli: a sigma 32-independent mecha... | [
1990,
1996,
1988,
2002,
2016,
2011
] | 6 | [] | [
"IPR011782",
"IPR011783",
"IPR047680"
] | 0 | 3 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
735,
70574,
13760,
28,
1371
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae... | [
59,
68,
2,
3,
15,
14,
1,
27,
16,
1,
1,
60
] | 12 | true | Family | Peptidase S1C | Peptidase S1C | Peptidase_S1C | 5 |
IPR001941 | 1,941 | Pro-opiomelanocortin | PMOC | Family | 5,375 | false | false | Pro-opiomelanocortin is present in high levels in the pituitary and is processed into 3 major peptide families: adrenocorticotrophin (ACTH); alpha-, beta- and gamma-melanocyte- stimulating hormones (MSH); and beta-endorphin [ ]. ACTH regulates the synthesis and release of glucocorticoids and, to some extent, aldosteron... | [
"GO:0005179",
"GO:0005576"
] | [
"hormone activity",
"extracellular region"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR00383"
] | [
"MELANOCORTIN"
] | [
5375
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-111885",
"R-BTA-193048",
"R-BTA-194002",
"R-BTA-202040",
"R-BTA-209952",
"R-BTA-211976",
"R-BTA-375276",
"R-BTA-418555",
"R-BTA-418594",
"R-HSA-111885",
"R-HSA-193048",
"R-HSA-194002",
"R-HSA-202040",
"R-HSA-209952",
"R-HSA-211976",
"R-HSA-375276",
"R-HSA-418555",
"R-HSA-418... | [
"REACTOME:R-BTA-111885",
"REACTOME:R-BTA-193048",
"REACTOME:R-BTA-194002",
"REACTOME:R-BTA-202040",
"REACTOME:R-BTA-209952",
"REACTOME:R-BTA-211976",
"REACTOME:R-BTA-375276",
"REACTOME:R-BTA-418555",
"REACTOME:R-BTA-418594",
"REACTOME:R-HSA-111885",
"REACTOME:R-HSA-193048",
"REACTOME:R-HSA-194... | 39 | [
"8gy7"
] | 1 | [
"PUB00000465",
"PUB00002596"
] | [
"2839146",
"2266117"
] | [
"Alpha-amidated peptides derived from pro-opiomelanocortin in normal human pituitary.",
"Post-translational modification of bovine pro-opiomelanocortin. Tyrosine sulfation and pyroglutamate formation, a mass spectrometric study."
] | [
1988,
1990
] | 2 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
5375
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
12,
1,
4
] | 4 | true | Family | Pro-opiomelanocortin | Pro-opiomelanocortin | PMOC | 5 |
IPR001943 | 1,943 | UVR domain | UVR_dom | Domain | 82,001 | false | false | During the process of Escherichia coli nucleotide excision repair, DNA damage recognition and processing are achieved by the action of the uvrA, uvrB, and uvrC gene products [ ]. UvrB and UvrC share a common domain of around 35 amino acids, the so called UVR domain. This domain in UvrB can interact with the homologous ... | [
"GO:0005515"
] | [
"protein binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE"
] | [
"PF02151",
"PS50151"
] | [
"UVR",
"UVR"
] | [
59795,
79291
] | 2 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC50151",
"R-HSA-8980692",
"R-HSA-9013026",
"R-HSA-9013106",
"R-MMU-8980692",
"R-MMU-9013026",
"R-MMU-9013106",
"R-RNO-8980692",
"R-RNO-9013026"
] | [
"PROSITEDOC:PDOC50151",
"REACTOME:R-HSA-8980692",
"REACTOME:R-HSA-9013026",
"REACTOME:R-HSA-9013106",
"REACTOME:R-MMU-8980692",
"REACTOME:R-MMU-9013026",
"REACTOME:R-MMU-9013106",
"REACTOME:R-RNO-8980692",
"REACTOME:R-RNO-9013026"
] | 9 | [
"1c4o",
"1d2m",
"1d9x",
"1d9z",
"1e52",
"1qoj",
"1t5l",
"2d7d",
"2fdc",
"2nmv",
"3j3r",
"3j3s",
"3j3t",
"3j3u",
"3pxg",
"3pxi",
"3uwx",
"3v4r",
"6em8",
"6em9",
"6emw",
"6lsy",
"6lt4",
"7abr",
"8a8u",
"8a8v",
"8a8w",
"8wtb",
"8wtc",
"8xon",
"8xoo",
"8ycx"... | 43 | [
"PUB00006064",
"PUB00006065",
"PUB00057847"
] | [
"8466476",
"8530482",
"15554981"
] | [
"Mechanism of action of the Escherichia coli UvrABC nuclease: clues to the damage recognition problem.",
"The C-terminal region of the UvrB protein of Escherichia coli contains an important determinant for UvrC binding to the preincision complex but not the catalytic site for 3'-incision.",
"Clp ATPases are req... | [
1993,
1995,
2004
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1220,
72453,
6717,
7,
1604
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
32,
1,
2,
2,
2,
21,
5,
46
] | 8 | true | Domain | UVR domain | UVR domain | UVR_dom | 9 |
IPR001944 | 1,944 | Glycoside hydrolase, family 35 | Glycoside_Hdrlase_35 | Family | 33,285 | false | false | Glycoside hydrolase family 35 ( ) comprises enzymes with only one known activity: beta-galactosidase ( ). Mammalian beta-galactosidase is a lysosomal enzyme (gene GLB1 ) that cleaves the terminal galactose from gangliosides, glycoproteins, and glycosaminoglycans and whose deficiency is the cause of the genetic disease ... | [
"GO:0004553",
"GO:0005975"
] | [
"hydrolase activity, hydrolyzing O-glycosyl compounds",
"carbohydrate metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PRINTS",
"PANTHER"
] | [
"PR00742",
"PTHR23421"
] | [
"GLHYDRLASE35",
""
] | [
30558,
33052
] | 2 | [
"CAZY",
"EC",
"METACYC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"RE... | [
"GH35",
"3.2.1.23",
"PWY-6807",
"PDOC00910",
"R-CFA-2022857",
"R-CFA-2024101",
"R-CFA-4085001",
"R-CFA-6798695",
"R-CFA-9840310",
"R-DDI-2022857",
"R-DDI-2024101",
"R-DDI-6798695",
"R-DDI-9840310",
"R-HSA-2022857",
"R-HSA-2024101",
"R-HSA-2206308",
"R-HSA-4085001",
"R-HSA-4341670",... | [
"CAZY:GH35",
"EC:3.2.1.23",
"METACYC:PWY-6807",
"PROSITEDOC:PDOC00910",
"REACTOME:R-CFA-2022857",
"REACTOME:R-CFA-2024101",
"REACTOME:R-CFA-4085001",
"REACTOME:R-CFA-6798695",
"REACTOME:R-CFA-9840310",
"REACTOME:R-DDI-2022857",
"REACTOME:R-DDI-2024101",
"REACTOME:R-DDI-6798695",
"REACTOME:R-... | 29 | [
"1tg7",
"1xc6",
"3d3a",
"3og2",
"3ogr",
"3ogs",
"3ogv",
"3thc",
"3thd",
"3w5f",
"3w5g",
"3wez",
"3wf0",
"3wf1",
"3wf2",
"3wf3",
"3wf4",
"4e8c",
"4e8d",
"4iug",
"4mad",
"5gsl",
"5gsm",
"5ifp",
"5ift",
"5ihr",
"5juv",
"5mgc",
"5mgd",
"6eon",
"6ik5",
"6ik6"... | 57 | [
"PUB00004870",
"PUB00005266",
"PUB00160296"
] | [
"7624375",
"8535779",
"35065074"
] | [
"Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.",
"Structures and mechanisms of glycosyl hydrolases.",
"Characterization and structural analyses of a novel glycosyltransferase acting on the β-1,2-glucosidic linkages."
] | [
1995,
1995,
2022
] | 3 | [] | [
"IPR026283"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
44,
7948,
25255,
38
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
107,
2,
10,
3,
21,
22,
2,
51,
27,
233
] | 10 | true | Family | Glycoside hydrolase, family 35 | Glycoside hydrolase, family 35 | Glycoside_Hdrlase_35 | 8 |
IPR001945 | 1,945 | RAD3/XPD | RAD3/XPD | Family | 4,487 | false | false | Xeroderma pigmentosum (XP) [ ] is a human autosomal recessive disease, characterised by a high incidence of sunlight-induced skin cancer. People's skin cells with this condition are hypersensitive to ultraviolet light, due to defects in the incision step of DNA excision repair. There are a minimum of seven genetic comp... | [
"GO:0003677",
"GO:0003678",
"GO:0005524",
"GO:0016818",
"GO:0006289",
"GO:0005634"
] | [
"DNA binding",
"DNA helicase activity",
"ATP binding",
"hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides",
"nucleotide-excision repair",
"nucleus"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 6 | [
"PRINTS"
] | [
"PR00852"
] | [
"XRODRMPGMNTD"
] | [
4487
] | 1 | [
"EC",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"5.6.2.3",
"GenProp2048",
"R-BTA-113418",
"R-BTA-5696395",
"R-BTA-5696400",
"R-BTA-674695",
"R-BTA-6781823",
"R-BTA-6782135",
"R-BTA-6782210",
"R-BTA-6796648",
"R-BTA-72086",
"R-BTA-73762",
"R-BTA-73772",
"R-BTA-73776",
"R-BTA-73779",
"R-BTA-73863",
"R-BTA-75953",
"R-BTA-75955",
... | [
"EC:5.6.2.3",
"GP:GenProp2048",
"REACTOME:R-BTA-113418",
"REACTOME:R-BTA-5696395",
"REACTOME:R-BTA-5696400",
"REACTOME:R-BTA-674695",
"REACTOME:R-BTA-6781823",
"REACTOME:R-BTA-6782135",
"REACTOME:R-BTA-6782210",
"REACTOME:R-BTA-6796648",
"REACTOME:R-BTA-72086",
"REACTOME:R-BTA-73762",
"REACT... | 111 | [
"5fmf",
"5ivw",
"5iy6",
"5iy7",
"5iy8",
"5iy9",
"5of4",
"5oqj",
"5oqm",
"5sva",
"6gym",
"6nmi",
"6o9l",
"6o9m",
"6ro4",
"6tun",
"7ad8",
"7egb",
"7egc",
"7ena",
"7enc",
"7k01",
"7k04",
"7lbm",
"7m2u",
"7ml0",
"7ml1",
"7ml2",
"7ml3",
"7ml4",
"7nvr",
"7nvw"... | 72 | [
"PUB00002008",
"PUB00002851",
"PUB00003894",
"PUB00004160",
"PUB00004189",
"PUB00004395",
"PUB00004415",
"PUB00005433",
"PUB00097845",
"PUB00154490"
] | [
"9101292",
"8206890",
"7920640",
"8247134",
"8090225",
"1956796",
"8464724",
"8160271",
"32821917",
"31253769"
] | [
"Mutations in the XPD gene leading to xeroderma pigmentosum symptoms.",
"Isolation of active recombinant XPG protein, a human DNA repair endonuclease.",
"Mutations in the xeroderma pigmentosum group D DNA repair/transcription gene in patients with trichothiodystrophy.",
"Yeast excision repair gene RAD2 encode... | [
1997,
1994,
1994,
1993,
1994,
1991,
1993,
1994,
2020,
2019
] | 10 | [
"IPR013020"
] | [] | 1 | 0 | 1 | [
"Eukaryota",
"bird metagenome"
] | [
4486,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
1,
1,
7,
7,
5,
1,
2,
4,
1,
1,
7
] | 12 | true | Family | RAD3/XPD | RAD3/XPD | RAD3/XPD | 5 |
IPR001946 | 1,946 | Alpha 2A adrenoceptor | ADRA2A_rcpt | Family | 230 | false | false | This entry represents the alpha 2A adrenoceptor. It is expressed at high levels in the CNS, and in peripheral tissues such as kidney, aorta, skeletal muscle, spleen and lung [ , , , ]. The adrenoceptors (or adrenergic receptors) are rhodopsin-like G protein-coupled receptors that are targets of the catecholamines, espe... | [
"GO:0004938",
"GO:0006940",
"GO:0007186",
"GO:0019229",
"GO:0030168",
"GO:0016020"
] | [
"alpha2-adrenergic receptor activity",
"regulation of smooth muscle contraction",
"G protein-coupled receptor signaling pathway",
"regulation of vasoconstriction",
"platelet activation",
"membrane"
] | [
"molecular_function",
"biological_process",
"biological_process",
"biological_process",
"biological_process",
"cellular_component"
] | 6 | [
"PRINTS"
] | [
"PR00558"
] | [
"ADRENRGCA2AR"
] | [
230
] | 1 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"... | [
"25",
"R-BTA-390696",
"R-BTA-392023",
"R-BTA-400042",
"R-BTA-418594",
"R-BTA-418597",
"R-BTA-5683826",
"R-HSA-390696",
"R-HSA-392023",
"R-HSA-400042",
"R-HSA-418594",
"R-HSA-418597",
"R-HSA-5683826",
"R-MMU-390696",
"R-MMU-392023",
"R-MMU-400042",
"R-MMU-418594",
"R-MMU-418597",
... | [
"IUPHAR:25",
"REACTOME:R-BTA-390696",
"REACTOME:R-BTA-392023",
"REACTOME:R-BTA-400042",
"REACTOME:R-BTA-418594",
"REACTOME:R-BTA-418597",
"REACTOME:R-BTA-5683826",
"REACTOME:R-HSA-390696",
"REACTOME:R-HSA-392023",
"REACTOME:R-HSA-400042",
"REACTOME:R-HSA-418594",
"REACTOME:R-HSA-418597",
"RE... | 31 | [
"6kux",
"6kuy",
"7ej0",
"7ej8",
"7eja",
"7ejk",
"7w6p",
"7w7e",
"9pln",
"9plo",
"9pqd"
] | 11 | [
"PUB00066376",
"PUB00066377",
"PUB00066395",
"PUB00066396",
"PUB00066462",
"PUB00066463",
"PUB00066464",
"PUB00066465",
"PUB00066466",
"PUB00066467",
"PUB00066468",
"PUB00066469",
"PUB00066470",
"PUB00066471",
"PUB00066472"
] | [
"18882199",
"2855960",
"2887122",
"9280371",
"9605427",
"9760042",
"9824686",
"8670422",
"15684247",
"2574568",
"10215710",
"7688069",
"1334200",
"7812219",
"7684725"
] | [
"A study of the adrenotropic receptors.",
"Subtypes of alpha 2-adrenoceptors: pharmacological and molecular biological evidence converge.",
"Coronary vasoconstriction mediated by alpha 1- and alpha 2-adrenoceptors in conscious dogs.",
"Alpha-adrenoceptors in equine digital veins: evidence for the presence of ... | [
1948,
1988,
1987,
1997,
1998,
1998,
1998,
1996,
2004,
1989,
1999,
1993,
1992,
1994,
1993
] | 15 | [
"IPR002233"
] | [] | 1 | 0 | 1 | [
"Eukaryota",
"Streptomyces"
] | [
228,
2
] | 2 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
2
] | 3 | true | Family | Alpha 2A adrenoceptor | Alpha 2A adrenoceptor | ADRA2A_rcpt | 4 |
IPR001947 | 1,947 | Scorpion short chain toxin, potassium channel inhibitor | Scorpion_toxinS_K_inh | Family | 254 | false | false | Scorpion venoms contain a variety of peptides toxic to mammals, insects and crustaceans. Among these peptides there is a family of short toxins (30 to 40 residues) [ , ]. This entry represents members of this family with potassium channel blocking activity [ ]. KTX 12 Sp2 toxin from Scorpiops pococki has shown a strong... | [
"GO:0008200",
"GO:0005576"
] | [
"ion channel inhibitor activity",
"extracellular region"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM",
"PRINTS"
] | [
"PF00451",
"PR00286"
] | [
"Toxin_2",
"CHARYBDTOXIN"
] | [
254,
139
] | 2 | [
"PROSITEDOC"
] | [
"PDOC00875"
] | [
"PROSITEDOC:PDOC00875"
] | 1 | [
"1agt",
"1bah",
"1big",
"1bkt",
"1c49",
"1c55",
"1c56",
"1cmr",
"1hly",
"1hp2",
"1j5j",
"1ktx",
"1lgl",
"1lir",
"1m2s",
"1mtx",
"1n8m",
"1pjv",
"1pnh",
"1q2k",
"1qky",
"1quz",
"1r1g",
"1sco",
"1scy",
"1sxm",
"1tsk",
"1txm",
"1wmt",
"1wpd",
"1wt7",
"1wz5"... | 83 | [
"PUB00000410",
"PUB00000536",
"PUB00030001",
"PUB00095583",
"PUB00097194",
"PUB00097857"
] | [
"7819188",
"7998956",
"15146482",
"31890149",
"32602722",
"33466524"
] | [
"NMR sequential assignments and solution structure of chlorotoxin, a small scorpion toxin that blocks chloride channels.",
"Novel K(+)-channel-blocking toxins from the venom of the scorpion Centruroides limpidus limpidus Karsch.",
"Solution structure of BmKK2, a new potassium channel blocker from the venom of c... | [
1995,
1994,
2004,
2019,
2020,
2021
] | 6 | [] | [] | 0 | 0 | null | [
"Corallococcus sicarius",
"Eukaryota"
] | [
1,
253
] | 2 | [] | [] | 0 | true | Family | Scorpion short chain toxin, potassium channel inhibitor | Scorpion short chain toxin, potassium channel inhibitor | Scorpion_toxinS_K_inh | 5 |
IPR001948 | 1,948 | Peptidase M18 | Peptidase_M18 | Family | 16,090 | false | false | This group of metallopeptidases belong to the MEROPS peptidase family M18, (clan MH). The proteins have two catalytic zinc ions at the active site, bound by His/Asp, Asp, Glu, Asp/Glu and His. The catalysed reaction involves the release of an N-terminal aminoacid, usually neutral or hydrophobic, from a polypeptide [ ].... | [
"GO:0004177",
"GO:0008270",
"GO:0006508"
] | [
"aminopeptidase activity",
"zinc ion binding",
"proteolysis"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM",
"PRINTS",
"PANTHER"
] | [
"PF02127",
"PR00932",
"PTHR28570"
] | [
"Peptidase_M18",
"AMINO1PTASE",
""
] | [
16084,
15532,
15980
] | 3 | [
"EC",
"METACYC",
"METACYC",
"METACYC"
] | [
"3.4.11.-",
"PWY-6423",
"PWY-7694",
"PWY-7954"
] | [
"EC:3.4.11.-",
"METACYC:PWY-6423",
"METACYC:PWY-7694",
"METACYC:PWY-7954"
] | 4 | [
"1y7e",
"2glf",
"2glj",
"2ijz",
"3var",
"3vat",
"3wt4",
"4dyo",
"4eme",
"4njq",
"4njr",
"4oid",
"4oiw",
"4r8f",
"5jgf",
"5jh9",
"5jm6",
"5jm9",
"6pev",
"7dde",
"7u5h"
] | 21 | [
"PUB00002544",
"PUB00003579"
] | [
"2651436",
"7674922"
] | [
"Molecular cloning and sequencing of genomic DNA encoding aminopeptidase I from Saccharomyces cerevisiae.",
"Evolutionary families of metallopeptidases."
] | [
1989,
1995
] | 2 | [] | [
"IPR022983",
"IPR022984"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
22,
8721,
7194,
153
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"S... | [
9,
2,
2,
16,
11,
2,
5,
10,
2,
1,
10
] | 11 | true | Family | Peptidase M18 | Peptidase M18 | Peptidase_M18 | 1 |
IPR001949 | 1,949 | NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site | NADH-UbQ_OxRdtase_51kDa_CS | Conserved_site | 28,332 | false | false | Among the many polypeptide subunits that make up complex I, there is one with a molecular weight of 51kDa (in mammals), which is the second largest subunit of complex I and is a component of the iron-sulphur (IP) fragment of the enzyme. It seems to bind to NAD, FMN, and a 2Fe-2S cluster. The 51kDa subunit and the bacte... | [
"GO:0008137",
"GO:0010181",
"GO:0051539"
] | [
"NADH dehydrogenase (ubiquinone) activity",
"FMN binding",
"4 iron, 4 sulfur cluster binding"
] | [
"molecular_function",
"molecular_function",
"molecular_function"
] | 3 | [
"PROSITE",
"PROSITE"
] | [
"PS00644",
"PS00645"
] | [
"COMPLEX1_51K_1",
"COMPLEX1_51K_2"
] | [
18989,
27899
] | 2 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"7.1.1.-",
"PDOC00555",
"R-DDI-6799198",
"R-DDI-9837999",
"R-HSA-611105",
"R-HSA-6799198",
"R-HSA-9837999",
"R-MMU-611105",
"R-MMU-6799198",
"R-MMU-9837999"
] | [
"EC:7.1.1.-",
"PROSITEDOC:PDOC00555",
"REACTOME:R-DDI-6799198",
"REACTOME:R-DDI-9837999",
"REACTOME:R-HSA-611105",
"REACTOME:R-HSA-6799198",
"REACTOME:R-HSA-9837999",
"REACTOME:R-MMU-611105",
"REACTOME:R-MMU-6799198",
"REACTOME:R-MMU-9837999"
] | 10 | [
"2fug",
"2ybb",
"3i9v",
"3iam",
"3ias",
"3m9s",
"4hea",
"5gpn",
"5gup",
"5lc5",
"5ldw",
"5ldx",
"5lnk",
"5o31",
"5xf9",
"5xfa",
"5xtb",
"5xtd",
"5xth",
"5xti",
"6g2j",
"6g72",
"6gcs",
"6hl2",
"6hl3",
"6hl4",
"6hla",
"6hli",
"6hlj",
"6hlm",
"6i0d",
"6i1p"... | 369 | [
"PUB00005074",
"PUB00043561",
"PUB00045437"
] | [
"1470679",
"10940377",
"18394423"
] | [
"The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains.",
"The respiratory complex I of bacteria, archaea and eukarya and its module common with membrane-bound multisubunit hydrogenases.",
"Assembly of the Escherichia coli NADH:ubiquinone oxidoreductase (complex I)."
] | [
1992,
2000,
2008
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
65,
22666,
4888,
713
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
2,
1,
1,
4,
1,
9,
4,
1,
5,
4,
10
] | 11 | true | Conserved_site | NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site | NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site | NADH-UbQ_OxRdtase_51kDa_CS | 8 |
IPR001950 | 1,950 | SUI1 domain | SUI1 | Domain | 25,141 | false | false | In budding yeast (Saccharomyces cerevisiae), SUI1 is a translation initiation factor that functions in concert with eIF-2 and the initiator tRNA-Met in directing the ribosome to the proper start site of translation [ ]. SUI1 is a protein of 108 residues. Close homologues of SUI1 have been found [ ] in mammals, insects ... | [
"GO:0003743",
"GO:0006413"
] | [
"translation initiation factor activity",
"translational initiation"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PROFILE"
] | [
"PF01253",
"PS50296"
] | [
"SUI1",
"SUI1"
] | [
25019,
25014
] | 2 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC00862",
"R-DME-5389840",
"R-DME-5419276",
"R-DME-9937383"
] | [
"PROSITEDOC:PDOC00862",
"REACTOME:R-DME-5389840",
"REACTOME:R-DME-5419276",
"REACTOME:R-DME-9937383"
] | 4 | [
"1d1r",
"2if1",
"2ogh",
"2rvh",
"3j80",
"3j81",
"3jam",
"3jap",
"4bts",
"4kzx",
"4kzy",
"4mo0",
"4uer",
"4v5o",
"5jb3",
"5jbh",
"5oa3",
"5oa9",
"5vyc",
"5w2f",
"5zcy",
"6gsm",
"6gsn",
"6vpq",
"6vpr",
"6ybw",
"6zce",
"6zmw",
"6zp4",
"6zvj",
"7a09",
"7ase"... | 43 | [
"PUB00000232",
"PUB00003679"
] | [
"7904817",
"1729602"
] | [
"Expressed sequence tags identify a human isolog of the suil translation initiation factor.",
"The suil suppressor locus in Saccharomyces cerevisiae encodes a translation factor that functions during tRNA(iMet) recognition of the start codon."
] | [
1994,
1992
] | 2 | [] | [
"IPR039759",
"IPR046447"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Megaviricetes",
"unclassified sequences"
] | [
1121,
7190,
16632,
43,
155
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
21,
3,
5,
7,
1,
11,
12,
2,
19,
21,
3,
2,
48
] | 13 | true | Domain | SUI1 domain | SUI1 domain | SUI1 | 9 |
IPR001951 | 1,951 | Histone H4 | Histone_H4 | Family | 13,871 | false | false | Histone H4 is one of the five histones, along with H1/H5, H2A, H2B and H3. Two copies of each of the H2A, H2B, H3, and H4 histones ensemble to form the core of the nucleosome [ ]. The nucleosome forms octameric structure that wraps DNA in a left-handed manner. H3 is a highly conserved protein of 135 amino acid residues... | [
"GO:0003677",
"GO:0030527"
] | [
"DNA binding",
"structural constituent of chromatin"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PRINTS",
"PANTHER",
"SMART",
"CDD"
] | [
"PR00623",
"PTHR10484",
"SM00417",
"cd22912"
] | [
"HISTONEH4",
"",
"H4",
"HFD_H4"
] | [
13151,
13126,
13034,
13007
] | 4 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00046",
"R-BTA-110330",
"R-BTA-110331",
"R-BTA-171306",
"R-BTA-201722",
"R-BTA-212300",
"R-BTA-2299718",
"R-BTA-2559580",
"R-BTA-2559582",
"R-BTA-2559586",
"R-BTA-3214815",
"R-BTA-3214841",
"R-BTA-3214842",
"R-BTA-3214847",
"R-BTA-3214858",
"R-BTA-427359",
"R-BTA-427413",
"R-B... | [
"PROSITEDOC:PDOC00046",
"REACTOME:R-BTA-110330",
"REACTOME:R-BTA-110331",
"REACTOME:R-BTA-171306",
"REACTOME:R-BTA-201722",
"REACTOME:R-BTA-212300",
"REACTOME:R-BTA-2299718",
"REACTOME:R-BTA-2559580",
"REACTOME:R-BTA-2559582",
"REACTOME:R-BTA-2559586",
"REACTOME:R-BTA-3214815",
"REACTOME:R-BTA... | 279 | [
"1aoi",
"1eqz",
"1f66",
"1hio",
"1hq3",
"1id3",
"1kx3",
"1kx4",
"1kx5",
"1m18",
"1m19",
"1m1a",
"1p34",
"1p3a",
"1p3b",
"1p3f",
"1p3g",
"1p3i",
"1p3k",
"1p3l",
"1p3m",
"1p3o",
"1p3p",
"1s32",
"1tzy",
"1u35",
"1zbb",
"1zla",
"2aro",
"2cv5",
"2f8n",
"2fj7"... | 971 | [
"PUB00003642",
"PUB00004015",
"PUB00004388",
"PUB00004448",
"PUB00040100",
"PUB00056944",
"PUB00061022",
"PUB00066796",
"PUB00095672",
"PUB00100973",
"PUB00150375",
"PUB00156085",
"PUB00157111",
"PUB00157117",
"PUB00157122",
"PUB00157123",
"PUB00157124",
"PUB00157125",
"PUB001571... | [
"6808351",
"3340182",
"2041803",
"8121801",
"15951514",
"21812398",
"20498094",
"16472024",
"30886146",
"31353180",
"29280735",
"24251097",
"31542297",
"27016736",
"26607036",
"32327602",
"6314274",
"27105115",
"27105113"
] | [
"Acetylation of histones in nucleosomes.",
"A highly basic histone H4 domain bound to the sharply bent region of nucleosomal DNA.",
"Histone and histone gene compilation and alignment update.",
"Phylogenetic analysis of the core histones H2A, H2B, H3, and H4.",
"Alteration of the nucleosomal DNA path in the... | [
1982,
1988,
1991,
1994,
2005,
2011,
2010,
2006,
2019,
2019,
2017,
2013,
2019,
2016,
2015,
2020,
1983,
2016,
2016
] | 19 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"organismal metagenomes"
] | [
5,
4,
13749,
110,
3
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
7,
2,
5,
4,
2,
6,
2,
1,
1,
44
] | 12 | true | Family | Histone H4 | Histone H4 | Histone_H4 | 4 |
IPR001952 | 1,952 | Alkaline phosphatase | Alkaline_phosphatase | Family | 23,211 | false | false | This entry represents alkaline phosphatases ( ) (ALP), which act as non-specific phosphomonoesterases to hydrolyse phosphate esters, optimally at high pH. The reaction mechanism involves the attack of a serine alkoxide on a phosphorus of the substrate to form a transient covalent enzyme-phosphate complex, followed by t... | [
"GO:0016791"
] | [
"phosphatase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PRINTS",
"PANTHER",
"SMART",
"CDD"
] | [
"PF00245",
"PR00113",
"PTHR11596",
"SM00098",
"cd16012"
] | [
"Alk_phosphatase",
"ALKPHPHTASE",
"",
"alkPPc",
"ALP"
] | [
23202,
21403,
22971,
21963,
21217
] | 5 | [
"EC",
"GP",
"GP",
"GP",
"GP",
"METACYC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.1.3.1",
"GenProp1255",
"GenProp1407",
"GenProp1411",
"GenProp1630",
"PWY-5491",
"PDOC00113",
"R-BTA-163125",
"R-DME-1483166",
"R-DME-6811438",
"R-DME-8935690",
"R-HSA-1483166",
"R-HSA-163125",
"R-HSA-6811438",
"R-HSA-8935690",
"R-MMU-163125",
"R-MMU-6811438",
"R-RNO-1483166",
... | [
"EC:3.1.3.1",
"GP:GenProp1255",
"GP:GenProp1407",
"GP:GenProp1411",
"GP:GenProp1630",
"METACYC:PWY-5491",
"PROSITEDOC:PDOC00113",
"REACTOME:R-BTA-163125",
"REACTOME:R-DME-1483166",
"REACTOME:R-DME-6811438",
"REACTOME:R-DME-8935690",
"REACTOME:R-HSA-1483166",
"REACTOME:R-HSA-163125",
"REACT... | 21 | [
"1aja",
"1ajb",
"1ajc",
"1ajd",
"1alh",
"1ali",
"1alj",
"1alk",
"1ani",
"1anj",
"1b8j",
"1ed8",
"1ed9",
"1elx",
"1ely",
"1elz",
"1ew2",
"1ew8",
"1ew9",
"1hjk",
"1hqa",
"1k7h",
"1kh4",
"1kh5",
"1kh7",
"1kh9",
"1khj",
"1khk",
"1khl",
"1khn",
"1shn",
"1shq"... | 86 | [
"PUB00003744",
"PUB00024691",
"PUB00038439",
"PUB00038859",
"PUB00042958",
"PUB00042959",
"PUB00042960",
"PUB00042961"
] | [
"1654502",
"11124260",
"15938627",
"15946677",
"11910033",
"17520090",
"18292227",
"17719863"
] | [
"Genetics of streptomycin production in Streptomyces griseus: nucleotide sequence of five genes, strFGHIK, including a phosphatase gene.",
"Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity.",
"Metal specificity is correlated with two cruc... | [
1991,
2001,
2005,
2005,
2002,
2007,
2008,
2007
] | 8 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
89,
11445,
11523,
1,
153
] | 5 | [
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe... | [
7,
16,
2,
12,
17,
3,
18,
1,
1,
1
] | 10 | true | Family | Alkaline phosphatase | Alkaline phosphatase | Alkaline_phosphatase | 2 |
IPR001953 | 1,953 | Sodium/hydrogen exchanger 2/4 | NHE-2/4 | Family | 851 | false | false | Sodium proton exchangers (NHEs) constitute a large family of integral membrane protein transporters that are responsible for the counter-transport of protons and sodium ions across lipid bilayers [ , ]. These proteins are found in organisms across all domains of life. In archaea, bacteria, yeast and plants, these excha... | [
"GO:0015385",
"GO:0006814",
"GO:0006885",
"GO:0016020"
] | [
"sodium:proton antiporter activity",
"sodium ion transport",
"regulation of pH",
"membrane"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PRINTS"
] | [
"PR01086"
] | [
"NAHEXCHNGR2"
] | [
851
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-425986",
"R-MMU-425986",
"R-RNO-425986"
] | [
"REACTOME:R-HSA-425986",
"REACTOME:R-MMU-425986",
"REACTOME:R-RNO-425986"
] | 3 | [] | 0 | [
"PUB00001715",
"PUB00002996",
"PUB00003039",
"PUB00044828",
"PUB00044829",
"PUB00044830",
"PUB00044831",
"PUB00044832",
"PUB00044833",
"PUB00044834",
"PUB00100472",
"PUB00100473",
"PUB00100474",
"PUB00100475",
"PUB00100476",
"PUB00100477"
] | [
"9537504",
"9278382",
"9507001",
"12027219",
"12502567",
"16734752",
"17071327",
"16513813",
"11187762",
"17218973",
"19458287",
"7961960",
"9038815",
"17943310",
"26350456",
"34785669"
] | [
"Comparative molecular analysis of Na+/H+ exchangers: a unified model for Na+/H+ antiport?",
"Na+/H+ exchangers of mammalian cells.",
"Identification of a mitochondrial Na+/H+ exchanger.",
"The Na+/H+ exchanger gene family.",
"Multiple modes of regulation of Na+/H+ exchangers.",
"Na+/H+ exchangers and the... | [
1998,
1997,
1998,
2002,
2002,
2006,
2006,
2006,
2000,
2006,
2009,
1994,
1997,
2008,
2015,
2021
] | 16 | [
"IPR004709"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
851
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
9
] | 3 | true | Family | Sodium/hydrogen exchanger 2/4 | Sodium/hydrogen exchanger 2/4 | NHE-2/4 | 2 |
IPR001954 | 1,954 | Gliadin/LMW glutenin | Glia_glutenin | Family | 5,019 | false | false | Gluten is the protein component of Triticum aestivum (Wheat) flour. It consists of numerous proteins, which are of 2 different types responsible for different physical properties of dough: the glutenins, which are primarily responsible for the elasticity, and the gliadins, which contribute to the extensibility. The glu... | [
"GO:0045735"
] | [
"nutrient reservoir activity"
] | [
"molecular_function"
] | 1 | [
"PRINTS",
"PANTHER"
] | [
"PR00208",
"PTHR33454"
] | [
"GLIADGLUTEN",
""
] | [
4030,
4999
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00001754",
"PUB00002416",
"PUB00004336",
"PUB00004360",
"PUB00082623"
] | [
"3017812",
"2989281",
"3840588",
"2563152",
"27503660"
] | [
"Structure of wheat gamma-gliadin genes.",
"Evolution and heterogeneity of the alpha-/beta-type and gamma-type gliadin DNA sequences.",
"Nucleotide sequence of a gene from chromosome 1D of wheat encoding a HMW-glutenin subunit.",
"Nucleotide sequences of the two high-molecular-weight glutenin genes from the D... | [
1986,
1985,
1985,
1989,
2016
] | 5 | [] | [] | 0 | 0 | null | [
"Mesangiospermae",
"Pseudomonadati"
] | [
5006,
13
] | 2 | [
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
60,
39
] | 2 | true | Family | Gliadin/LMW glutenin | Gliadin/LMW glutenin | Glia_glutenin | 7 |
IPR001956 | 1,956 | Carbohydrate-binding module 3 | CBM3 | Domain | 3,351 | false | false | Carbohydrate-binding modules (CBM) have been classified into more than 40 families according to sequence homology. Several cellulolytic enzymes share a conserved region of about 150 amino acid residues, the CBM3 domain [ ]. It has been classified in three different subtypes, termed family IIIa, IIIb and IIIc. The famil... | [
"GO:0030248",
"GO:0005975"
] | [
"cellulose binding",
"carbohydrate metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF00942",
"PS51172",
"SM01067"
] | [
"CBM_3",
"CBM3",
"CBM_3"
] | [
3340,
3281,
3141
] | 3 | [
"EC",
"METACYC",
"PROSITEDOC"
] | [
"3.2.1.4",
"PWY-6788",
"PDOC51172"
] | [
"EC:3.2.1.4",
"METACYC:PWY-6788",
"PROSITEDOC:PDOC51172"
] | 3 | [
"1g43",
"1g87",
"1ga2",
"1js4",
"1k72",
"1kfg",
"1nbc",
"1tf4",
"2l8a",
"2wnx",
"2wo4",
"2wob",
"2xbt",
"2xfg",
"2ylk",
"3tf4",
"3zqw",
"3zqx",
"3zu8",
"3zuc",
"4b96",
"4b97",
"4b9c",
"4b9f",
"4b9p",
"4c8x",
"4jo5",
"4tf4",
"5gxx",
"5gxy",
"5gxz",
"5gy0"... | 42 | [
"PUB00001296",
"PUB00001730",
"PUB00025133",
"PUB00033741",
"PUB00033742"
] | [
"8918451",
"1490597",
"11092922",
"9537366",
"9055408"
] | [
"Crystal structure of a bacterial family-III cellulose-binding domain: a general mechanism for attachment to cellulose.",
"Identification of the cellulose-binding domain of the cellulosome subunit S1 from Clostridium thermocellum YS.",
"Structure of a family IIIa scaffoldin CBD from the cellulosome of Clostridi... | [
1996,
1992,
2000,
1998,
1997
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Haloarculaceae",
"bioreactor metagenome"
] | [
3323,
22,
5,
1
] | 4 | [] | [] | 0 | true | Domain | Carbohydrate-binding module 3 | Carbohydrate-binding module 3 | CBM3 | 3 |
IPR001957 | 1,957 | Chromosomal replication control, initiator DnaA | Chromosome_initiator_DnaA | Family | 25,509 | false | false | The bacterial DnaA protein [ , , ] plays an important role in initiating and regulating chromosomal replication. DnaA is an ATP- and DNA-binding protein. It binds specifically to 9 bp nucleotide repeats known as dnaA boxes which are found in the chromosome origin of replication (oriC). DnaA contains two conserved regio... | [
"GO:0003677",
"GO:0003688",
"GO:0005524",
"GO:0006270",
"GO:0006275"
] | [
"DNA binding",
"DNA replication origin binding",
"ATP binding",
"DNA replication initiation",
"regulation of DNA replication"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process",
"biological_process"
] | 5 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_00377",
"TIGR00362"
] | [
"DnaA_bact",
"DnaA"
] | [
25049,
25455
] | 2 | [
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"PROSITEDOC"
] | [
"GenProp0806",
"GenProp1113",
"GenProp1152",
"GenProp1186",
"GenProp1195",
"GenProp1200",
"GenProp1207",
"GenProp1210",
"PDOC00771"
] | [
"GP:GenProp0806",
"GP:GenProp1113",
"GP:GenProp1152",
"GP:GenProp1186",
"GP:GenProp1195",
"GP:GenProp1200",
"GP:GenProp1207",
"GP:GenProp1210",
"PROSITEDOC:PDOC00771"
] | 9 | [
"1l8q",
"2hcb",
"2z4r",
"2z4s",
"3r8f",
"8btg",
"8bv3"
] | 7 | [
"PUB00000665",
"PUB00001793",
"PUB00003815",
"PUB00005517"
] | [
"8110826",
"2172087",
"1779750",
"2558436"
] | [
"The initiator protein DnaA: evolution, properties and function.",
"Nucleotide sequence of a Proteus mirabilis DNA fragment homologous to the 60K-rnpA-rpmH-dnaA-dnaN-recF-gyrB region of Escherichia coli.",
"Structure and function of DnaA and the DnaA-box in eubacteria: evolutionary relationships of bacterial re... | [
1994,
1990,
1991,
1989
] | 4 | [
"IPR020591"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"Microviridae sp. ctNWS1",
"unclassified sequences"
] | [
25017,
40,
2,
1,
449
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Chromosomal replication control, initiator DnaA | Chromosomal replication control, initiator DnaA | Chromosome_initiator_DnaA | 7 |
IPR001959 | 1,959 | Probable transposase, IS891/IS1136/IS1341 | Transposase | Domain | 32,776 | false | false | This entry represents a conserved region of a probable transposase family, which is found in a number prokaryotic and viral proteins, including the insertion sequence (IS)-like element of the Bacillus PS3 (Thermophilic bacterium PS-3) that promotes expression of the alanine carrier protein-encoding gene [ ] and IS1136 ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01385"
] | [
"OrfB_IS605"
] | [
32776
] | 1 | [] | [] | [] | 0 | [
"8bf8",
"8ex9",
"8exa",
"8h1j",
"8iaz",
"9b0l",
"9j09",
"9udi"
] | 8 | [
"PUB00001825",
"PUB00001858",
"PUB00002091",
"PUB00100808",
"PUB00100809"
] | [
"8386127",
"7557457",
"2553665",
"34619744",
"20090938"
] | [
"IS1136, an insertion element in the erythromycin gene cluster of Saccharopolyspora erythraea.",
"A novel insertion sequence (IS)-like element of the thermophilic bacterium PS3 promotes expression of the alanine carrier protein-encoding gene.",
"Characterization of an insertion sequence (IS891) of novel structu... | [
1993,
1995,
1989,
2021,
2010
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
3771,
28281,
84,
256,
384
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Probable transposase, IS891/IS1136/IS1341 | Probable transposase, IS891/IS1136/IS1341 | Transposase | 7 |
IPR001962 | 1,962 | Asparagine synthase | Asn_synthase | Domain | 51,348 | false | false | Most family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase [glutamine-hydrolyzing] (ASNS, ) catalyses the assembly of asparagine from aspartate, Mg(2+)ATP, and glutamine [ , , ]. The three-dimensional architecture of the N-terminal domain of asparagine synthet... | [] | [] | [] | 0 | [
"PFAM",
"CDD"
] | [
"PF00733",
"cd01991"
] | [
"Asn_synthase",
"Asn_synthase_B_C"
] | [
50927,
42837
] | 2 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"6.3.5.4",
"R-BTA-8963693",
"R-DDI-8963693",
"R-HSA-380994",
"R-HSA-8963693",
"R-HSA-9633012",
"R-HSA-9648895",
"R-MMU-8963693",
"R-RNO-8963693",
"R-SCE-8963693",
"R-SPO-8963693"
] | [
"EC:6.3.5.4",
"REACTOME:R-BTA-8963693",
"REACTOME:R-DDI-8963693",
"REACTOME:R-HSA-380994",
"REACTOME:R-HSA-8963693",
"REACTOME:R-HSA-9633012",
"REACTOME:R-HSA-9648895",
"REACTOME:R-MMU-8963693",
"REACTOME:R-RNO-8963693",
"REACTOME:R-SCE-8963693",
"REACTOME:R-SPO-8963693"
] | 11 | [
"1ct9",
"1jgt",
"1m1z",
"1mb9",
"1mbz",
"1mc1",
"1q15",
"1q19",
"6gq3",
"7ylz",
"8sue",
"9b6c"
] | 12 | [
"PUB00002540",
"PUB00006460",
"PUB00043790",
"PUB00080257",
"PUB00161693"
] | [
"2564390",
"10587437",
"2573597",
"11551215",
"32638637"
] | [
"Expression of human asparagine synthetase in Escherichia coli.",
"Three-dimensional structure of Escherichia coli asparagine synthetase B: a short journey from substrate to product.",
"The N-terminal cysteine of human asparagine synthetase is essential for glutamine-dependent activity.",
"Characterization of... | [
1989,
1999,
1989,
2001,
2020
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1747,
36337,
12286,
76,
902
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
19,
3,
3,
2,
1,
7,
5,
2,
7,
7,
3,
2,
49
] | 13 | true | Domain | Asparagine synthase | Asparagine synthase | Asn_synthase | 9 |
IPR001964 | 1,964 | Luteovirus VPG protein | Luteo_VPG | Family | 1,510 | false | false | The nucleotide sequence of the RNA of Potato leafroll virus (PLrV) has been determined [ , ]. The sequence contains six large ORFs. The 3' coding region encodes three polypeptides: a 23K coat protein, a 17K polypeptide encoded in a different frame, and a 53K polypeptide, immediately following the coat protein sequence ... | [] | [] | [] | 0 | [
"PFAM",
"PRINTS"
] | [
"PF01659",
"PR00912"
] | [
"Luteo_Vpg",
"LVIRUSORF5"
] | [
1510,
1266
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00001567",
"PUB00003126"
] | [
"2466700",
"2732710"
] | [
"Nucleotide sequence and organization of potato leafroll virus genomic RNA.",
"Nucleotide sequence of potato leafroll luteovirus RNA."
] | [
1989,
1989
] | 2 | [] | [] | 0 | 0 | null | [
"Viruses"
] | [
1510
] | 1 | [] | [] | 0 | true | Family | Luteovirus VPG protein | Luteovirus VPG protein | Luteo_VPG | 9 |
IPR001965 | 1,965 | Zinc finger, PHD-type | Znf_PHD | Domain | 240,751 | false | false | This entry represents the PHD (homeodomain) zinc finger domain [ ], which is a C4HC3 zinc-finger-like motif found in nuclear proteins thought to be involved in chromatin-mediated transcriptional regulation. The PHD finger motif is reminiscent of, but distinct from the C3HC4 type RING finger. The function of this domain... | [] | [] | [] | 0 | [
"SMART"
] | [
"SM00249"
] | [
"PHD"
] | [
240751
] | 1 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC50016",
"R-BTA-6807505",
"R-BTA-9772755",
"R-CEL-114608",
"R-CEL-2299718",
"R-CEL-3214842",
"R-CEL-3214847",
"R-CEL-4551638",
"R-CEL-6804758",
"R-CEL-9031628",
"R-DME-114608",
"R-DME-201722",
"R-DME-209407",
"R-DME-209421",
"R-DME-3214815",
"R-DME-6804758",
"R-DME-6807505",
"R... | [
"PROSITEDOC:PDOC50016",
"REACTOME:R-BTA-6807505",
"REACTOME:R-BTA-9772755",
"REACTOME:R-CEL-114608",
"REACTOME:R-CEL-2299718",
"REACTOME:R-CEL-3214842",
"REACTOME:R-CEL-3214847",
"REACTOME:R-CEL-4551638",
"REACTOME:R-CEL-6804758",
"REACTOME:R-CEL-9031628",
"REACTOME:R-DME-114608",
"REACTOME:R-... | 172 | [
"1f62",
"1fp0",
"1mm2",
"1mm3",
"1we9",
"1wee",
"1wem",
"1wen",
"1wep",
"1wes",
"1weu",
"1wev",
"1wew",
"1x4i",
"1xwh",
"2dx8",
"2e6r",
"2e6s",
"2f6j",
"2f6n",
"2fsa",
"2fui",
"2fuu",
"2g6q",
"2jmi",
"2jmj",
"2k16",
"2k17",
"2k1j",
"2ke1",
"2kft",
"2kgg"... | 465 | [
"PUB00005446",
"PUB00014077",
"PUB00035804",
"PUB00035805",
"PUB00035806",
"PUB00035807",
"PUB00035812"
] | [
"7701562",
"12665246",
"17210253",
"15963892",
"15718139",
"10529348",
"11179890"
] | [
"The PHD finger: implications for chromatin-mediated transcriptional regulation.",
"Zinc fingers--folds for many occasions.",
"Sticky fingers: zinc-fingers as protein-recognition motifs.",
"Multiple modes of RNA recognition by zinc finger proteins.",
"Zinc finger proteins: getting a grip on RNA.",
"Zinc f... | [
1995,
2002,
2007,
2005,
2005,
1999,
2001
] | 7 | [] | [
"IPR019787",
"IPR034732",
"IPR039095",
"IPR042015",
"IPR042017",
"IPR043319",
"IPR047010",
"IPR047432",
"IPR047442",
"IPR047458",
"IPR047527",
"IPR055197",
"IPR055198",
"IPR059102"
] | 0 | 14 | 0 | [
"Bacteria",
"Eukaryota",
"Haloarculaceae",
"metagenomes",
"unclassified Marseilleviridae"
] | [
2,
240725,
9,
13,
2
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
707,
61,
680,
103,
463,
298,
21,
203,
399,
15,
17,
1070
] | 12 | true | Domain | Zinc finger, PHD-type | Zinc finger, PHD-type | Znf_PHD | 3 |
IPR001966 | 1,966 | Gastrin-releasing peptide receptor | Gastrin_pep_rcpt | Family | 652 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0008528",
"GO:0007186",
"GO:0016020"
] | [
"G protein-coupled peptide receptor activity",
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR00640"
] | [
"GASTRINRELPR"
] | [
652
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-375276",
"R-HSA-416476",
"R-MMU-375276",
"R-MMU-416476",
"R-RNO-375276",
"R-RNO-416476"
] | [
"REACTOME:R-HSA-375276",
"REACTOME:R-HSA-416476",
"REACTOME:R-MMU-375276",
"REACTOME:R-MMU-416476",
"REACTOME:R-RNO-375276",
"REACTOME:R-RNO-416476"
] | 6 | [
"8h0q"
] | 1 | [
"PUB00000131",
"PUB00002477",
"PUB00004960",
"PUB00004961",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816"
] | [
"2111655",
"2830256",
"8386361",
"8170923",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293"
] | [
"G proteins in signal transduction.",
"G protein involvement in receptor-effector coupling.",
"Design of a discriminating fingerprint for G-protein-coupled receptors.",
"Fingerprinting G-protein-coupled receptors.",
"The G protein-coupled receptor repertoires of human and mouse.",
"GCRDb: a G-protein-coup... | [
1990,
1988,
1993,
1994,
2003,
1994,
2005,
2009,
2006,
2013
] | 10 | [
"IPR001556"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
652
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
1,
1
] | 4 | true | Family | Gastrin-releasing peptide receptor | Gastrin-releasing peptide receptor | Gastrin_pep_rcpt | 1 |
IPR001967 | 1,967 | Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, N-terminal | Peptidase_S11_N | Domain | 49,799 | false | false | Proteolytic enzymes that exploit serine in their catalytic activity are ubiquitous, being found in viruses, bacteria and eukaryotes [ ]. They include a wide range of peptidase activity, including exopeptidase, endopeptidase, oligopeptidase and omega-peptidase activity. Many families of serine protease have been identif... | [
"GO:0009002",
"GO:0006508"
] | [
"serine-type D-Ala-D-Ala carboxypeptidase activity",
"proteolysis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF00768"
] | [
"Peptidase_S11"
] | [
49799
] | 1 | [
"EC",
"METACYC",
"METACYC"
] | [
"3.4.16.4",
"PWY-5265",
"PWY-6471"
] | [
"EC:3.4.16.4",
"METACYC:PWY-5265",
"METACYC:PWY-6471"
] | 3 | [
"1es2",
"1es3",
"1es4",
"1es5",
"1esi",
"1hd8",
"1j9m",
"1nj4",
"1nzo",
"1nzu",
"1sdn",
"1skf",
"1tvf",
"1xp4",
"1z6f",
"3a3j",
"3beb",
"3bec",
"3hum",
"3hun",
"3it9",
"3ita",
"3itb",
"3mfd",
"3mzd",
"3mze",
"3mzf",
"4drt",
"4k91",
"4p0m",
"4ppr",
"4rye"... | 57 | [
"PUB00000120",
"PUB00000499",
"PUB00000522",
"PUB00003576"
] | [
"1741619",
"1930140",
"8439290",
"7845208"
] | [
"Serine beta-lactamases and penicillin-binding proteins.",
"Amino acid sequence of the penicillin-binding protein/DD-peptidase of Streptomyces K15. Predicted secondary structures of the low Mr penicillin-binding proteins of class A.",
"Evolutionary families of peptidases.",
"Families of serine peptidases."
] | [
1991,
1991,
1993,
1994
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
49135,
10,
272,
382
] | 4 | [
"Escherichia coli (strain K12)"
] | [
4
] | 1 | true | Domain | Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, N-terminal | Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, N-terminal | Peptidase_S11_N | 2 |
IPR001969 | 1,969 | Aspartic peptidase, active site | Aspartic_peptidase_AS | Active_site | 456,804 | false | false | This signature contains the active site residues which are conserved in eukaryotic and viral aspartyl proteases. Aspartic peptidase, also known as aspartyl proteases ([ec:3.4.23.-]) are a widely distributed family of proteolytic enzymes [ , , ] known to exist in vertebrates, fungi, plants, retroviruses and some plant v... | [
"GO:0004190",
"GO:0006508"
] | [
"aspartic-type endopeptidase activity",
"proteolysis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PROSITE"
] | [
"PS00141"
] | [
"ASP_PROTEASE"
] | [
456804
] | 1 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.4.23",
"PDOC00128",
"R-CEL-2022377",
"R-CEL-5683826",
"R-CFA-1442490",
"R-CFA-2022377",
"R-CFA-2132295",
"R-CFA-5683826",
"R-CFA-6798695",
"R-CFA-77387",
"R-DDI-2132295",
"R-DDI-5683826",
"R-DDI-6798695",
"R-GGA-2022377",
"R-GGA-2132295",
"R-GGA-6798695",
"R-GGA-77387",
"R-HSA-1... | [
"EC:3.4.23",
"PROSITEDOC:PDOC00128",
"REACTOME:R-CEL-2022377",
"REACTOME:R-CEL-5683826",
"REACTOME:R-CFA-1442490",
"REACTOME:R-CFA-2022377",
"REACTOME:R-CFA-2132295",
"REACTOME:R-CFA-5683826",
"REACTOME:R-CFA-6798695",
"REACTOME:R-CFA-77387",
"REACTOME:R-DDI-2132295",
"REACTOME:R-DDI-5683826",... | 52 | [
"1a30",
"1a8g",
"1a8k",
"1a94",
"1a9m",
"1aaq",
"1aid",
"1ajv",
"1ajx",
"1am5",
"1apt",
"1apu",
"1apv",
"1apw",
"1avf",
"1axa",
"1az5",
"1b11",
"1b5f",
"1b6j",
"1b6k",
"1b6l",
"1b6m",
"1b6p",
"1bai",
"1bbs",
"1bdl",
"1bdq",
"1bdr",
"1bil",
"1bim",
"1bv7"... | 2,554 | [
"PUB00000093",
"PUB00000349",
"PUB00000522",
"PUB00001330",
"PUB00011023",
"PUB00011707",
"PUB00021296",
"PUB00042504",
"PUB00065205",
"PUB00066803",
"PUB00076784",
"PUB00076785",
"PUB00076786"
] | [
"2194475",
"1851433",
"8439290",
"6795036",
"10331925",
"11566868",
"10864493",
"2682266",
"23254940",
"21765428",
"4912600",
"10497172",
"21751400"
] | [
"The structure and function of the aspartic proteinases.",
"Structural and evolutionary relationships between retroviral and eucaryotic aspartic proteinases.",
"Evolutionary families of peptidases.",
"Gastric proteinases--structure, function, evolution and mechanism of action.",
"Crystal structure of the hy... | [
1990,
1991,
1993,
1981,
1999,
2001,
2000,
1989,
2013,
2011,
1970,
1999,
2011
] | 13 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
122,
10774,
93792,
351957,
159
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
224,
14,
80,
23,
68,
62,
11,
458,
33,
38,
14,
240
] | 12 | true | Active_site | Aspartic peptidase, active site | Aspartic peptidase, active site | Aspartic_peptidase_AS | 9 |
IPR001971 | 1,971 | Small ribosomal subunit protein uS11 | Ribosomal_uS11 | Family | 49,734 | false | false | Small ribosomal subunit protein uS11, previously known as Ribosomal protein S11 [ ], plays an essential role in selecting the correct tRNA in protein biosynthesis. It is located on the large lobe of the small ribosomal subunit. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. ... | [
"GO:0003735",
"GO:0006412",
"GO:0005840"
] | [
"structural constituent of ribosome",
"translation",
"ribosome"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"HAMAP",
"PFAM",
"PIRSF",
"PANTHER"
] | [
"MF_01310",
"PF00411",
"PIRSF002131",
"PTHR11759"
] | [
"Ribosomal_uS11",
"Ribosomal_S11",
"Ribosomal_S11",
""
] | [
47818,
49316,
43809,
48937
] | 4 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00053",
"R-CEL-156827",
"R-CEL-1799339",
"R-CEL-6791226",
"R-CEL-72649",
"R-CEL-72689",
"R-CEL-72695",
"R-CEL-72702",
"R-CEL-72706",
"R-CEL-975956",
"R-CEL-975957",
"R-DDI-156827",
"R-DDI-1799339",
"R-DDI-6791226",
"R-DDI-72689",
"R-DDI-72695",
"R-DDI-72702",
"R-DDI-72706",
... | [
"PROSITEDOC:PDOC00053",
"REACTOME:R-CEL-156827",
"REACTOME:R-CEL-1799339",
"REACTOME:R-CEL-6791226",
"REACTOME:R-CEL-72649",
"REACTOME:R-CEL-72689",
"REACTOME:R-CEL-72695",
"REACTOME:R-CEL-72702",
"REACTOME:R-CEL-72706",
"REACTOME:R-CEL-975956",
"REACTOME:R-CEL-975957",
"REACTOME:R-DDI-156827"... | 86 | [
"1fjg",
"1hnw",
"1hnx",
"1hnz",
"1hr0",
"1i94",
"1i95",
"1i96",
"1i97",
"1ibk",
"1ibl",
"1ibm",
"1j5e",
"1jgo",
"1jgp",
"1jgq",
"1ml5",
"1n32",
"1n33",
"1n34",
"1n36",
"1vvj",
"1vy4",
"1vy5",
"1vy6",
"1vy7",
"1x18",
"1xmo",
"1xmq",
"1xnq",
"1xnr",
"2e5l"... | 1,906 | [
"PUB00001562",
"PUB00007068",
"PUB00007069",
"PUB00007070",
"PUB00086615"
] | [
"3191988",
"11297922",
"11290319",
"11114498",
"14568531"
] | [
"Amino acid sequences of ribosomal proteins S11 from Bacillus stearothermophilus and S19 from Halobacterium marismortui. Comparison of the ribosomal protein S11 family.",
"Atomic structures at last: the ribosome in 2000.",
"The ribosome in focus.",
"The end of the beginning: structural studies of ribosomal pr... | [
1988,
2001,
2001,
2000,
2003
] | 5 | [] | [
"IPR019961",
"IPR019981"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
903,
23063,
25275,
493
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
17,
2,
2,
5,
1,
7,
9,
2,
18,
9,
3,
3,
43
] | 13 | true | Family | Small ribosomal subunit protein uS11 | Small ribosomal subunit protein uS11 | Ribosomal_uS11 | 6 |
IPR001972 | 1,972 | Stomatin/HflK family | Stomatin_HflK_fam | Family | 46,946 | false | false | This entry includes human Stomatin, bacterial HflK and similar proteins from all cellular organisms. The band-7 protein family comprises a diverse set of membrane-bound proteins characterised by the presence of a conserved domain, the band-7 domain, also known as SPFH or PHB domain. The exact function of the band-7 dom... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PRINTS"
] | [
"PR00721"
] | [
"STOMATIN"
] | [
46946
] | 1 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00977",
"R-CEL-2672351",
"R-CEL-373753",
"R-CEL-6798695",
"R-CEL-8980692",
"R-CEL-9013026",
"R-CEL-9013406",
"R-CEL-9013407",
"R-DME-2672351",
"R-DME-373753",
"R-DME-6798695",
"R-DME-8980692",
"R-DME-9013026",
"R-DME-9013406",
"R-DME-9013407",
"R-HSA-2672351",
"R-HSA-373753",
... | [
"PROSITEDOC:PDOC00977",
"REACTOME:R-CEL-2672351",
"REACTOME:R-CEL-373753",
"REACTOME:R-CEL-6798695",
"REACTOME:R-CEL-8980692",
"REACTOME:R-CEL-9013026",
"REACTOME:R-CEL-9013406",
"REACTOME:R-CEL-9013407",
"REACTOME:R-DME-2672351",
"REACTOME:R-DME-373753",
"REACTOME:R-DME-6798695",
"REACTOME:R-... | 40 | [
"2rpb",
"3bk6",
"4fvf",
"4fvg",
"4fvj",
"7vhp",
"7vhq",
"7wh3",
"7wi3",
"8gn9",
"8z5g",
"9cz1",
"9cz2",
"9oh9"
] | 14 | [
"PUB00002046",
"PUB00068598",
"PUB00068600",
"PUB00068627",
"PUB00076124",
"PUB00093790",
"PUB00093791"
] | [
"9147127",
"15471860",
"12239636",
"21501885",
"24782879",
"28575093",
"19684140"
] | [
"Stomatin.",
"Stomatin modulates gating of acid-sensing ion channels.",
"Cloning and characterization of SLP3: a novel member of the stomatin family expressed by olfactory receptor neurons.",
"Stomatin-domain proteins.",
"Mitochondrial Band-7 family proteins: scaffolds for respiratory chain assembly?",
"S... | [
1997,
2004,
2003,
2012,
2014,
2017,
2009
] | 7 | [] | [
"IPR043202"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Mimiviridae",
"unclassified sequences"
] | [
1221,
30187,
15032,
26,
480
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
9,
33,
16,
20,
2,
16,
18,
2,
4,
14,
1,
5
] | 12 | true | Family | Stomatin/HflK family | Stomatin/HflK family | Stomatin_HflK_fam | 6 |
IPR001973 | 1,973 | P2Y6 purinoceptor | P2Y6_rcpt | Family | 207 | false | false | There are three distinct families of extracellular receptors for purine and pyrimidine nucleotides [ ], known as P1, P2X and P2Y purinoceptors [ ]. These receptors induce a wide variety of biological effects and are involved in many different cellular functions [ , , ]. P2X receptors are ligand-gated ion channels, wher... | [
"GO:0045028",
"GO:0007186",
"GO:0016020"
] | [
"G protein-coupled purinergic nucleotide receptor activity",
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01068"
] | [
"P2Y6PRNOCPTR"
] | [
207
] | 1 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"326",
"R-HSA-416476",
"R-HSA-417957",
"R-MMU-416476",
"R-MMU-417957",
"R-RNO-416476",
"R-RNO-417957"
] | [
"IUPHAR:326",
"REACTOME:R-HSA-416476",
"REACTOME:R-HSA-417957",
"REACTOME:R-MMU-416476",
"REACTOME:R-MMU-417957",
"REACTOME:R-RNO-416476",
"REACTOME:R-RNO-417957"
] | 7 | [] | 0 | [
"PUB00002928",
"PUB00007054",
"PUB00028347",
"PUB00033968",
"PUB00066193",
"PUB00066194",
"PUB00066195",
"PUB00066196",
"PUB00066197",
"PUB00066198",
"PUB00066203",
"PUB00066204",
"PUB00066205",
"PUB00066206",
"PUB00066207",
"PUB00066208",
"PUB00066209",
"PUB00066210",
"PUB000662... | [
"7592819",
"12270951",
"8872457",
"11111826",
"10629443",
"20471713",
"11099464",
"19921464",
"11734617",
"16257449",
"9364468",
"7724657",
"16968944",
"8508924",
"19386608",
"8921391",
"8702478",
"12724320",
"18404483",
"9755289",
"11794691",
"16914897",
"16934527",
"1... | [
"Molecular cloning and functional analysis of a novel P2 nucleotide receptor.",
"Molecular physiology of P2X receptors.",
"Modelling the P2Y purinoceptor using rhodopsin as template.",
"Molecular pharmacology of P2Y-receptors.",
"Renal vascular reactivity to P(2)-purinoceptor activation in spontaneously hyp... | [
1995,
2002,
1995,
2000,
2000,
2011,
2000,
2010,
2001,
2006,
1997,
1994,
2006,
1993,
2009,
1996,
1996,
2003,
2006,
1998,
2001,
2006,
2006,
2000,
2001,
1996,
1996,
1997,
2008,
2008
] | 30 | [
"IPR000276"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
207
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
2,
2
] | 3 | true | Family | P2Y6 purinoceptor | P2Y6 purinoceptor | P2Y6_rcpt | 3 |
IPR001975 | 1,975 | Large ribosomal subunit protein eL40 domain | Ribosomal_eL40_dom | Domain | 5,524 | false | false | This entry represents the L40 ribosomal domain from both archaea and eukaryotes. In eukaryotes, L40 is fused to ubiquitin moieties, and this fusion protein is known as Ubiquitin-ribosomal protein eL40 fusion protein or UBL40 [ , ]. Specific endopeptidases cleave these precursor molecules to release ubiquitin moieties [... | [
"GO:0003735",
"GO:0006412",
"GO:0005840"
] | [
"structural constituent of ribosome",
"translation",
"ribosome"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"SMART"
] | [
"PF01020",
"SM01377"
] | [
"Ribosomal_L40e",
"Ribosomal_L40e"
] | [
5344,
5200
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-110312",
"R-BTA-110314",
"R-BTA-110320",
"R-BTA-1169091",
"R-BTA-1234176",
"R-BTA-1253288",
"R-BTA-1295596",
"R-BTA-1358803",
"R-BTA-156827",
"R-BTA-168638",
"R-BTA-174048",
"R-BTA-174084",
"R-BTA-174113",
"R-BTA-174154",
"R-BTA-174178",
"R-BTA-174184",
"R-BTA-179409",
"R-BT... | [
"REACTOME:R-BTA-110312",
"REACTOME:R-BTA-110314",
"REACTOME:R-BTA-110320",
"REACTOME:R-BTA-1169091",
"REACTOME:R-BTA-1234176",
"REACTOME:R-BTA-1253288",
"REACTOME:R-BTA-1295596",
"REACTOME:R-BTA-1358803",
"REACTOME:R-BTA-156827",
"REACTOME:R-BTA-168638",
"REACTOME:R-BTA-174048",
"REACTOME:R-BT... | 792 | [
"2ayj",
"3j6x",
"3j6y",
"3j77",
"3j78",
"3j79",
"3j7o",
"3j7p",
"3j7q",
"3j7r",
"3j92",
"3jag",
"3jah",
"3jai",
"3jaj",
"3jan",
"3jbn",
"3jbo",
"3jbp",
"4adx",
"4d5y",
"4d67",
"4u3m",
"4u3n",
"4u3u",
"4u4n",
"4u4o",
"4u4q",
"4u4r",
"4u4u",
"4u4y",
"4u4z"... | 483 | [
"PUB00000250",
"PUB00007068",
"PUB00007069",
"PUB00007070",
"PUB00083511",
"PUB00083514",
"PUB00083520",
"PUB00083521",
"PUB00101554",
"PUB00151163",
"PUB00151164"
] | [
"7488009",
"11297922",
"11290319",
"11114498",
"15571815",
"16185873",
"22297692",
"25208476",
"32669547",
"35613268",
"23169626"
] | [
"The carboxyl extensions of two rat ubiquitin fusion proteins are ribosomal proteins S27a and L40.",
"Atomic structures at last: the ribosome in 2000.",
"The ribosome in focus.",
"The end of the beginning: structural studies of ribosomal proteins.",
"Mechanism and function of deubiquitinating enzymes.",
"... | [
1995,
2001,
2001,
2000,
2004,
2005,
2012,
2014,
2020,
2022,
2013
] | 11 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
784,
6,
4713,
2,
19
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
1,
1,
2,
4,
4,
2,
20,
5,
2,
2,
10
] | 12 | true | Domain | Large ribosomal subunit protein eL40 domain | Large ribosomal subunit protein eL40 domain | Ribosomal_eL40_dom | 2 |
IPR001977 | 1,977 | Dephospho-CoA kinase | Depp_CoAkinase | Family | 32,347 | false | false | This family contains Dephospho-coenzyme A kinase (DPCK, ), which catalyzes the final step in dephosphocoenzyme A (dCoA) biosynthesis, the phosphorylation of the 3'-hydroxyl group of ribose using ATP as a phosphate donor. The crystal structures of a number of the proteins in this entry have been determined, including th... | [
"GO:0004140",
"GO:0005524",
"GO:0015937"
] | [
"dephospho-CoA kinase activity",
"ATP binding",
"coenzyme A biosynthetic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"HAMAP",
"PFAM",
"PROFILE",
"NCBIFAM"
] | [
"MF_00376",
"PF01121",
"PS51219",
"TIGR00152"
] | [
"Dephospho_CoA_kinase",
"CoaE",
"DPCK",
""
] | [
30613,
32138,
32211,
31402
] | 4 | [
"EC",
"GP",
"METACYC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.1.24",
"GenProp0171",
"PWY-7851",
"PDOC00996",
"R-CEL-196783",
"R-DRE-196783",
"R-HSA-196783",
"R-MMU-196783",
"R-RNO-196783",
"R-SCE-196783",
"R-SPO-196783",
"R-SSC-196783",
"R-XTR-196783"
] | [
"EC:2.7.1.24",
"GP:GenProp0171",
"METACYC:PWY-7851",
"PROSITEDOC:PDOC00996",
"REACTOME:R-CEL-196783",
"REACTOME:R-DRE-196783",
"REACTOME:R-HSA-196783",
"REACTOME:R-MMU-196783",
"REACTOME:R-RNO-196783",
"REACTOME:R-SCE-196783",
"REACTOME:R-SPO-196783",
"REACTOME:R-SSC-196783",
"REACTOME:R-XTR... | 13 | [
"1jjv",
"1n3b",
"1t3h",
"1uf9",
"1vhl",
"1vht",
"1viy",
"2f6r",
"2grj",
"2if2",
"4i1u",
"4i1v",
"4ttp",
"4ttq",
"4ttr",
"4zo4",
"6ari",
"6n39",
"8dv0",
"8sbn",
"8sbo",
"8u94",
"8u96",
"8u97",
"9bkz",
"9dug"
] | 26 | [
"PUB00026419"
] | [
"11886213"
] | [
"Crystal structure of dephospho-coenzyme A kinase from Haemophilus influenzae."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
10,
25076,
6586,
4,
671
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
5,
5,
3,
4,
1,
7,
5,
1,
2,
6,
1,
1,
10
] | 13 | true | Family | Dephospho-CoA kinase | Dephospho-CoA kinase | Depp_CoAkinase | 8 |
IPR001978 | 1,978 | Troponin | Troponin | Family | 16,040 | false | false | The troponin (Tn) complex regulates Ca 2+ induced muscle contraction. Tn contains three subunits, Ca 2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). This family includes troponin T and troponin I. Troponin I binds to actin and troponin T binds to tropomyosin [ , , ]. | [
"GO:0005861"
] | [
"troponin complex"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF00992"
] | [
"Troponin"
] | [
16040
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-390522",
"R-CEL-5578775",
"R-CFA-390522",
"R-CFA-5578775",
"R-DME-5578775",
"R-HSA-390522",
"R-HSA-5578775",
"R-MMU-390522",
"R-MMU-5578775",
"R-RNO-390522",
"R-RNO-5578775",
"R-SSC-390522"
] | [
"REACTOME:R-BTA-390522",
"REACTOME:R-CEL-5578775",
"REACTOME:R-CFA-390522",
"REACTOME:R-CFA-5578775",
"REACTOME:R-DME-5578775",
"REACTOME:R-HSA-390522",
"REACTOME:R-HSA-5578775",
"REACTOME:R-MMU-390522",
"REACTOME:R-MMU-5578775",
"REACTOME:R-RNO-390522",
"REACTOME:R-RNO-5578775",
"REACTOME:R-S... | 12 | [
"1a2x",
"1j1d",
"1j1e",
"1ytz",
"1yv0",
"2mzp",
"2n7l",
"2w49",
"2w4u",
"2z5h",
"4y99",
"5vln",
"5w88",
"5wcl",
"6klt",
"6klu",
"6kn7",
"6kn8",
"6mv3",
"7jgi",
"7kaa",
"7ko4",
"7ko5",
"7ko7",
"7kon",
"7kor",
"7sc2",
"7sc3",
"7sup",
"7svc",
"7swg",
"7swi"... | 80 | [
"PUB00001531",
"PUB00002926",
"PUB00004000"
] | [
"7601340",
"7852318",
"3102969"
] | [
"The troponin complex and regulation of muscle contraction.",
"A direct regulatory role for troponin T and a dual role for troponin C in the Ca2+ regulation of muscle contraction.",
"Structure of co-crystals of tropomyosin and troponin."
] | [
1995,
1995,
1987
] | 3 | [] | [
"IPR027707"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Lightbulbvirus",
"bird metagenome"
] | [
15,
16019,
5,
1
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
12,
85,
17,
58,
49,
46
] | 6 | true | Family | Troponin | Troponin | Troponin | 9 |
IPR001980 | 1,980 | Phosphopantetheine adenylyltransferase | PPAT | Family | 24,591 | false | false | Phosphopantetheine adenylyltransferase (PPAT; ) is an essential enzyme in bacteria, responsible for catalyzing the rate-limiting step in coenzyme A (CoA) biosynthesis: catalysis of the reversible transfer of an adenylyl group from ATP to 4'-phosphopantetheine to give dephospho-CoA (DPCOA) and pyrophosphate in the fourt... | [
"GO:0004595",
"GO:0015937"
] | [
"pantetheine-phosphate adenylyltransferase activity",
"coenzyme A biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"PRINTS",
"NCBIFAM",
"CDD"
] | [
"MF_00151",
"PR01020",
"TIGR01510",
"cd02163"
] | [
"PPAT_bact",
"LPSBIOSNTHSS",
"coaD_prev_kdtB",
"PPAT"
] | [
24058,
24470,
24219,
21738
] | 4 | [
"EC",
"GP",
"METACYC",
"METACYC"
] | [
"2.7.7.3",
"GenProp0171",
"PWY-7851",
"PWY-8342"
] | [
"EC:2.7.7.3",
"GP:GenProp0171",
"METACYC:PWY-7851",
"METACYC:PWY-8342"
] | 4 | [
"1b6t",
"1gn8",
"1h1t",
"1o6b",
"1od6",
"1qjc",
"1tfu",
"1vlh",
"3f3m",
"3k9w",
"3l92",
"3l93",
"3lcj",
"3nba",
"3nbk",
"3nd5",
"3nd6",
"3nd7",
"3nv7",
"3otw",
"3pnb",
"3pxu",
"3rba",
"3rff",
"3rhs",
"3uc5",
"3x1j",
"3x1k",
"3x1m",
"4e1a",
"4f3r",
"4nah"... | 118 | [
"PUB00000266",
"PUB00002701",
"PUB00015594",
"PUB00023529",
"PUB00036800",
"PUB00080721"
] | [
"10208837",
"2033061",
"10480925",
"10205156",
"11812124",
"17873050"
] | [
"CTP:phosphocholine cytidylyltransferase: insights into regulatory mechanisms and novel functions.",
"A gene coding for 3-deoxy-D-manno-octulosonic-acid transferase in Escherichia coli. Identification, mapping, cloning, and sequencing.",
"Purification and characterization of phosphopantetheine adenylyltransfera... | [
1999,
1991,
1999,
1999,
2002,
2007
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
18,
23863,
94,
12,
604
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Phosphopantetheine adenylyltransferase | Phosphopantetheine adenylyltransferase | PPAT | 6 |
IPR001981 | 1,981 | Colipase | Colipase | Family | 1,421 | false | false | Colipase [ , ] is a small protein cofactor needed by pancreatic lipase for efficient dietary lipid hydrolyisis. It also binds to the bile-salt covered triacylglycerol interface, thus allowing the enzyme to anchor itself to the water-lipid interface. Efficient absorption of dietary fats is dependent on the action of pan... | [
"GO:0008047",
"GO:0007586",
"GO:0016042",
"GO:0005576"
] | [
"enzyme activator activity",
"digestion",
"lipid catabolic process",
"extracellular region"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PRINTS",
"PROFILE",
"PANTHER",
"SMART"
] | [
"PR00128",
"PS51342",
"PTHR10041",
"SM00023"
] | [
"COLIPASE",
"COLIPASE_2",
"",
"COLIPASE"
] | [
769,
965,
1269,
767
] | 4 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC00111",
"R-BTA-192456",
"R-BTA-975634",
"R-HSA-192456",
"R-HSA-975634",
"R-MMU-192456",
"R-MMU-975634",
"R-RNO-192456",
"R-RNO-975634",
"R-SSC-192456",
"R-SSC-975634",
"R-XTR-192456",
"R-XTR-975634"
] | [
"PROSITEDOC:PDOC00111",
"REACTOME:R-BTA-192456",
"REACTOME:R-BTA-975634",
"REACTOME:R-HSA-192456",
"REACTOME:R-HSA-975634",
"REACTOME:R-MMU-192456",
"REACTOME:R-MMU-975634",
"REACTOME:R-RNO-192456",
"REACTOME:R-RNO-975634",
"REACTOME:R-SSC-192456",
"REACTOME:R-SSC-975634",
"REACTOME:R-XTR-1924... | 13 | [
"1eth",
"1lpa",
"1lpb",
"1n8s",
"1pcn",
"1pco"
] | 6 | [
"PUB00000630",
"PUB00000684",
"PUB00006457",
"PUB00006494"
] | [
"1567900",
"3147715",
"10570245",
"9240923"
] | [
"Pancreatic colipase. Structural and physiological aspects.",
"Minireview on pancreatic lipase and colipase.",
"Colipase: structure and interaction with pancreatic lipase.",
"Structure and function of pancreatic lipase and colipase."
] | [
1992,
1988,
1999,
1997
] | 4 | [] | [
"IPR047576"
] | 0 | 1 | 0 | [
"Enterobacteriaceae",
"Eukaryota"
] | [
2,
1419
] | 2 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
5,
8
] | 3 | true | Family | Colipase | Colipase | Colipase | 8 |
IPR001985 | 1,985 | S-adenosylmethionine decarboxylase, eukaryotes | S-AdoMet_decarboxylase_euk | Family | 5,525 | false | false | This entry includes S-adenosylmethionine decarboxylases from eukaryotes. S-adenosylmethionine decarboxylase (AdoMetDC) [ ] catalyses the removal of the carboxylate group of S-adenosylmethionine to form S-adenosyl-5'-3-methylpropylamine which then acts as the n-propylamine group donor in the synthesis of the polyamines ... | [
"GO:0004014",
"GO:0006597",
"GO:0008295"
] | [
"adenosylmethionine decarboxylase activity",
"spermine biosynthetic process",
"spermidine biosynthetic process"
] | [
"molecular_function",
"biological_process",
"biological_process"
] | 3 | [
"PIRSF",
"NCBIFAM"
] | [
"PIRSF001355",
"TIGR00535"
] | [
"S-AdenosylMet_decarboxylase",
"SAM_DCase"
] | [
3763,
5251
] | 2 | [
"EC",
"GP",
"METACYC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"4.1.1.50",
"GenProp1571",
"PWY-6834",
"PDOC01038",
"R-BTA-351202",
"R-CEL-351202",
"R-DDI-351202",
"R-DME-351202",
"R-HSA-351202",
"R-MMU-351202",
"R-RNO-351202",
"R-SCE-351202",
"R-SPO-351202"
] | [
"EC:4.1.1.50",
"GP:GenProp1571",
"METACYC:PWY-6834",
"PROSITEDOC:PDOC01038",
"REACTOME:R-BTA-351202",
"REACTOME:R-CEL-351202",
"REACTOME:R-DDI-351202",
"REACTOME:R-DME-351202",
"REACTOME:R-HSA-351202",
"REACTOME:R-MMU-351202",
"REACTOME:R-RNO-351202",
"REACTOME:R-SCE-351202",
"REACTOME:R-SPO... | 13 | [
"1i72",
"1i79",
"1i7b",
"1i7c",
"1i7m",
"1jen",
"1jl0",
"1mhm",
"1msv",
"3dz2",
"3dz3",
"3dz4",
"3dz5",
"3dz6",
"3dz7",
"3ep3",
"3ep4",
"3ep5",
"3ep6",
"3ep7",
"3ep8",
"3ep9",
"3epa",
"3epb",
"3h0v",
"3h0w",
"9p1h",
"9p7q",
"9pbb"
] | 29 | [
"PUB00006224"
] | [
"10378277"
] | [
"The crystal structure of human S-adenosylmethionine decarboxylase at 2.25 A resolution reveals a novel fold."
] | [
1999
] | 1 | [
"IPR048283"
] | [] | 1 | 0 | 1 | [
"Eukaryota",
"Pseudomonadati"
] | [
5520,
5
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
13,
1,
1,
2,
5,
3,
1,
12,
4,
1,
1,
13
] | 12 | true | Family | S-adenosylmethionine decarboxylase, eukaryotes | S-adenosylmethionine decarboxylase, eukaryotes | S-AdoMet_decarboxylase_euk | 3 |
IPR001986 | 1,986 | Enolpyruvate transferase domain | Enolpyruvate_Tfrase_dom | Domain | 66,279 | false | false | This entry represents the core domain of 3-phosphoshikimate 1-carboxyvinyltransferase and UDP-N-acetylglucosamine 1-carboxyvinyltransferase. These proteins transfer enolpryruvate from phosphoenolpyruvate to 3-phosphoshikimate and UDP-N-acetyl-alpha-D-glucosamine respectively [ , ]. The domain can also be found in the f... | [
"GO:0016765"
] | [
"transferase activity, transferring alkyl or aryl (other than methyl) groups"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF00275"
] | [
"EPSP_synthase"
] | [
66279
] | 1 | [
"EC",
"PROSITEDOC",
"REACTOME"
] | [
"2.5.1",
"PDOC00097",
"R-MTU-964903"
] | [
"EC:2.5.1",
"PROSITEDOC:PDOC00097",
"REACTOME:R-MTU-964903"
] | 3 | [
"1a2n",
"1dlg",
"1ejc",
"1ejd",
"1eps",
"1eyn",
"1g6s",
"1g6t",
"1mi4",
"1naw",
"1p88",
"1p89",
"1q36",
"1q3g",
"1rf4",
"1rf5",
"1rf6",
"1ryw",
"1uae",
"1x8r",
"1x8t",
"1ybg",
"2aa9",
"2aay",
"2bjb",
"2gg4",
"2gg6",
"2gga",
"2ggd",
"2o0b",
"2o0d",
"2o0e"... | 123 | [
"PUB00024300",
"PUB00031046",
"PUB00099962",
"PUB00099963"
] | [
"9685163",
"15103156",
"28064057",
"28830812"
] | [
"Structure of dehydroquinate synthase reveals an active site capable of multistep catalysis.",
"Structure of the 'open' form of Aspergillus nidulans 3-dehydroquinate synthase at 1.7 A resolution from crystals grown following enzyme turnover.",
"UDP-N-Acetylglucosamine enolpyruvyl transferase (MurA) of Acinetoba... | [
1998,
2004,
2017,
2017
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
882,
59903,
3985,
2,
1507
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
12,
2,
1,
6,
1,
1,
12
] | 7 | true | Domain | Enolpyruvate transferase domain | Enolpyruvate transferase domain | Enolpyruvate_Tfrase_dom | 7 |
IPR001989 | 1,989 | Radical-activating enzyme, conserved site | Radical_activat_CS | Conserved_site | 19,474 | false | false | In Escherichia coli and related bacteria, the pflA protein (or act) [ ] is involved ( ) in the activation of pyruvate formate-lyase (gene pflB) under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. The activi... | [
"GO:0016491",
"GO:0051539"
] | [
"oxidoreductase activity",
"4 iron, 4 sulfur cluster binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PROSITE"
] | [
"PS01087"
] | [
"RADICAL_ACTIVATING"
] | [
19474
] | 1 | [
"EC",
"PROSITEDOC"
] | [
"1.97.1",
"PDOC00834"
] | [
"EC:1.97.1",
"PROSITEDOC:PDOC00834"
] | 2 | [
"3c8f",
"3cb8",
"8fo0",
"8fol",
"8fsi"
] | 5 | [
"PUB00001367",
"PUB00002923",
"PUB00003594"
] | [
"3053170",
"7852304",
"7773398"
] | [
"Primary structures of Escherichia coli pyruvate formate-lyase and pyruvate-formate-lyase-activating enzyme deduced from the DNA nucleotide sequences.",
"Generation of the glycyl radical of the anaerobic Escherichia coli ribonucleotide reductase requires a specific activating enzyme.",
"Novel phosphotransferase... | [
1988,
1995,
1995
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
85,
18723,
121,
411,
134
] | 5 | [
"Escherichia coli (strain K12)"
] | [
5
] | 1 | true | Conserved_site | Radical-activating enzyme, conserved site | Radical-activating enzyme, conserved site | Radical_activat_CS | 7 |
IPR001990 | 1,990 | Chromogranin A/B/C | Granin | Family | 2,752 | false | false | Granins (chromogranins or secretogranins) [ ] are a family of acidic proteins present in the secretory granules of a wide variety of endocrine and neuro-endocrine cells. The exact function(s) of these proteins is not yet known but they seem to be the precursors of biologically active peptides and/or they may act as hel... | [
"GO:0030141"
] | [
"secretory granule"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF01271"
] | [
"Granin"
] | [
2752
] | 1 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC00365",
"R-BTA-381426",
"R-BTA-8957275",
"R-HSA-381426",
"R-HSA-6803157",
"R-HSA-8957275",
"R-MMU-381426",
"R-MMU-6803157",
"R-MMU-8957275",
"R-RNO-381426",
"R-RNO-6803157",
"R-RNO-8957275",
"R-SSC-381426",
"R-SSC-8957275"
] | [
"PROSITEDOC:PDOC00365",
"REACTOME:R-BTA-381426",
"REACTOME:R-BTA-8957275",
"REACTOME:R-HSA-381426",
"REACTOME:R-HSA-6803157",
"REACTOME:R-HSA-8957275",
"REACTOME:R-MMU-381426",
"REACTOME:R-MMU-6803157",
"REACTOME:R-MMU-8957275",
"REACTOME:R-RNO-381426",
"REACTOME:R-RNO-6803157",
"REACTOME:R-RN... | 14 | [] | 0 | [
"PUB00005374"
] | [
"2053134"
] | [
"The granin (chromogranin/secretogranin) family."
] | [
1991
] | 1 | [] | [
"IPR001819",
"IPR038858"
] | 0 | 2 | 0 | [
"Vertebrata"
] | [
2752
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
11,
10,
23
] | 4 | true | Family | Chromogranin A/B/C | Chromogranin A/B/C | Granin | 8 |
IPR001991 | 1,991 | Sodium:dicarboxylate symporter | Na-dicarboxylate_symporter | Family | 71,445 | false | false | It has been shown [ ] that integral membrane proteins that mediate the uptake of a wide variety of molecules with the concomitant uptake of sodium ions (sodium symporters) can be grouped, on the basis of sequence and functional similarities into a number of distinct families. One of these families is known as the sodiu... | [
"GO:0015293",
"GO:0016020"
] | [
"symporter activity",
"membrane"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF00375",
"PTHR42865"
] | [
"SDF",
""
] | [
71423,
52207
] | 2 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00591",
"R-BTA-210455",
"R-BTA-210500",
"R-BTA-352230",
"R-BTA-425393",
"R-BTA-9013149",
"R-BTA-9013406",
"R-BTA-9013407",
"R-BTA-9013423",
"R-CEL-210455",
"R-CEL-210500",
"R-CEL-352230",
"R-CEL-425393",
"R-CEL-9013149",
"R-CEL-9013406",
"R-CEL-9013407",
"R-CEL-9013423",
"R-HS... | [
"PROSITEDOC:PDOC00591",
"REACTOME:R-BTA-210455",
"REACTOME:R-BTA-210500",
"REACTOME:R-BTA-352230",
"REACTOME:R-BTA-425393",
"REACTOME:R-BTA-9013149",
"REACTOME:R-BTA-9013406",
"REACTOME:R-BTA-9013407",
"REACTOME:R-BTA-9013423",
"REACTOME:R-CEL-210455",
"REACTOME:R-CEL-210500",
"REACTOME:R-CEL-... | 43 | [
"1xfh",
"2nwl",
"2nww",
"2nwx",
"3kbc",
"3v8f",
"3v8g",
"4izm",
"4ky0",
"4oye",
"4oyf",
"4p19",
"4p1a",
"4p3j",
"4p6h",
"4x2s",
"5cfy",
"5dwy",
"5e9s",
"5llm",
"5llu",
"5lm4",
"5mju",
"6bat",
"6bau",
"6bav",
"6bmi",
"6ctf",
"6gct",
"6mp6",
"6mpb",
"6r7r"... | 125 | [
"PUB00000660",
"PUB00004137",
"PUB00004138",
"PUB00004767"
] | [
"8031825",
"1448170",
"1280334",
"1279699"
] | [
"A functional superfamily of sodium/solute symporters.",
"Cloning and expression of a rat brain L-glutamate transporter.",
"Primary structure and functional characterization of a high-affinity glutamate transporter.",
"Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate tra... | [
1994,
1992,
1992,
1992
] | 4 | [] | [
"IPR023025",
"IPR023954",
"IPR034703"
] | 0 | 3 | 0 | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
373,
53449,
3,
17187,
433
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
32,
8,
4,
69,
40,
55
] | 7 | true | Family | Sodium:dicarboxylate symporter | Sodium:dicarboxylate symporter | Na-dicarboxylate_symporter | 8 |
IPR001992 | 1,992 | T2SS_GspF/T4SS_PilC conserved site | T2SS_GspF/T4SS_PilC_CS | Conserved_site | 12,070 | false | false | GspF is the inner membrane component of the type II secretion system (T2SS). It interacts with GspE, a cytoplasmic hexameric ATPase of the T2SS [ ]. It shows considerable sequence similarity to PilC, which is required for the formation of type IV pili [ ]. The type II secretion system (T2SS) is one of several extracell... | [
"GO:0009306",
"GO:0016020"
] | [
"protein secretion",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PROSITE"
] | [
"PS00874"
] | [
"T2SP_F"
] | [
12070
] | 1 | [
"PROSITEDOC"
] | [
"PDOC00682"
] | [
"PROSITEDOC:PDOC00682"
] | 1 | [] | 0 | [
"PUB00051842",
"PUB00093998",
"PUB00094002",
"PUB00094004",
"PUB00094010"
] | [
"19217396",
"30767847",
"28258547",
"22523076",
"17464073"
] | [
"Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody.",
"Architecture, Function, and Substrates of the Type II Secretion System.",
"1H, 15N and 13C resonance assignments and secondary structure of PulG, the major pseudopilin from Klebsiella oxyt... | [
2009,
2019,
2017,
2012,
2007
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
11820,
22,
228
] | 3 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Conserved_site | T2SS_GspF/T4SS_PilC conserved site | T2SS_GspF/T4SS_PilC conserved site | T2SS_GspF/T4SS_PilC_CS | 2 |
IPR001995 | 1,995 | Peptidase A2A, retrovirus, catalytic | Peptidase_A2_cat | Domain | 384,106 | false | false | This group of aspartic peptidases belong to the peptidase clan AA. The clan includes the single domain aspartic proteases from retroviruses, retrotransposons, and badnaviruses (plant dsDNA viruses) which are active as homodimers. While fungal and mammalian pepsins are bilobal proteins with structurally related N- and C... | [
"GO:0004190",
"GO:0006508"
] | [
"aspartic-type endopeptidase activity",
"proteolysis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PROFILE"
] | [
"PS50175"
] | [
"ASP_PROT_RETROV"
] | [
384106
] | 1 | [
"EC",
"EC",
"EC",
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",... | [
"2.7.7.-",
"2.7.7.49",
"2.7.7.7",
"3.1.26",
"3.4.23",
"PWY-6322",
"PWY-6626",
"PWY-6749",
"PWY-6955",
"PWY-6998",
"PWY-7127",
"PWY-7419",
"PWY-7529",
"PWY-7706",
"PWY-7719",
"PWY-7735",
"PWY-7737",
"PWY-7769",
"PWY-7888",
"PWY-7904",
"PWY-8117",
"PWY-8179",
"PDOC00128",
... | [
"EC:2.7.7.-",
"EC:2.7.7.49",
"EC:2.7.7.7",
"EC:3.1.26",
"EC:3.4.23",
"METACYC:PWY-6322",
"METACYC:PWY-6626",
"METACYC:PWY-6749",
"METACYC:PWY-6955",
"METACYC:PWY-6998",
"METACYC:PWY-7127",
"METACYC:PWY-7419",
"METACYC:PWY-7529",
"METACYC:PWY-7706",
"METACYC:PWY-7719",
"METACYC:PWY-7735... | 36 | [
"1a30",
"1a8g",
"1a8k",
"1a94",
"1a9m",
"1aaq",
"1aid",
"1ajv",
"1ajx",
"1axa",
"1az5",
"1b11",
"1b6j",
"1b6k",
"1b6l",
"1b6m",
"1b6p",
"1bai",
"1bdl",
"1bdq",
"1bdr",
"1bv7",
"1bv9",
"1bve",
"1bvg",
"1bwa",
"1bwb",
"1c6x",
"1c6y",
"1c6z",
"1c70",
"1cpi"... | 963 | [
"PUB00000093",
"PUB00000349",
"PUB00000522",
"PUB00001330",
"PUB00011023",
"PUB00011707",
"PUB00021296",
"PUB00032703",
"PUB00041573",
"PUB00042504",
"PUB00048142",
"PUB00065205",
"PUB00066803",
"PUB00076754",
"PUB00076784",
"PUB00076785",
"PUB00076786",
"PUB00076788",
"PUB000767... | [
"2194475",
"1851433",
"8439290",
"6795036",
"10331925",
"11566868",
"10864493",
"8841139",
"17010377",
"2682266",
"18597783",
"23254940",
"21765428",
"16395329",
"4912600",
"10497172",
"21751400",
"15831103",
"9311808"
] | [
"The structure and function of the aspartic proteinases.",
"Structural and evolutionary relationships between retroviral and eucaryotic aspartic proteinases.",
"Evolutionary families of peptidases.",
"Gastric proteinases--structure, function, evolution and mechanism of action.",
"Crystal structure of the hy... | [
1990,
1991,
1993,
1981,
1999,
2001,
2000,
1996,
2006,
1989,
2008,
2013,
2011,
2006,
1970,
1999,
2011,
2005,
1997
] | 19 | [] | [
"IPR018061"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
118,
4156,
18451,
361315,
66
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
4,
17,
8,
21,
19,
1,
31,
1,
1,
1
] | 10 | true | Domain | Peptidase A2A, retrovirus, catalytic | Peptidase A2A, retrovirus, catalytic | Peptidase_A2_cat | 8 |
IPR001996 | 1,996 | Phosphotransferase system, IIB component, type 1 | PTS_IIB_1 | Domain | 44,446 | false | false | This entry represents the component IIB of the glucose family of PTS systems (type 1). Several PTS permease families are currently recognised, namely, the (i) glucose (including glucoside), (ii) fructose (including mannitol), (iii) lactose (including N,N-diacetylchitobiose), (iv) galactitol, (v) glucitol, (vi) mannose,... | [
"GO:0008982",
"GO:0009401"
] | [
"protein-N(PI)-phosphohistidine-sugar phosphotransferase activity",
"phosphoenolpyruvate-dependent sugar phosphotransferase system"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PROFILE",
"NCBIFAM"
] | [
"PS51098",
"TIGR00826"
] | [
"PTS_EIIB_TYPE_1",
"EIIB_glc"
] | [
44425,
27199
] | 2 | [
"EC",
"GP",
"PROSITEDOC"
] | [
"2.7.1",
"GenProp0119",
"PDOC00795"
] | [
"EC:2.7.1",
"GP:GenProp0119",
"PROSITEDOC:PDOC00795"
] | 3 | [
"1iba",
"1o2f",
"3bp3",
"3bp8",
"3ipj",
"8qsr",
"8qst",
"9hnp"
] | 8 | [
"PUB00000073",
"PUB00002162",
"PUB00003612",
"PUB00070132"
] | [
"2197982",
"1537788",
"8246840",
"16339738"
] | [
"The bacterial phosphoenolpyruvate: glycose phosphotransferase system.",
"Proposed uniform nomenclature for the proteins and protein domains of the bacterial phosphoenolpyruvate: sugar phosphotransferase system.",
"Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria.",
"Comparative genomic... | [
1990,
1992,
1993,
2005
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
44330,
41,
75
] | 3 | [
"Escherichia coli (strain K12)"
] | [
8
] | 1 | true | Domain | Phosphotransferase system, IIB component, type 1 | Phosphotransferase system, IIB component, type 1 | PTS_IIB_1 | 4 |
IPR001997 | 1,997 | Calponin/LIMCH1 | Calponin/LIMCH1 | Family | 5,206 | false | false | Calponin is a smooth muscle-specific, actin-, tropomyosin- and calmodulin-binding protein believed to be involved in regulation or modulation of contraction [ , ]. Interaction of the protein with actin inhibits actomyosin MgATPase activity. Multiple isoforms are found in smooth muscle [ ]. Calponin is a basic protein o... | [
"GO:0003779",
"GO:0031032"
] | [
"actin binding",
"actomyosin structure organization"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PRINTS"
] | [
"PR00889"
] | [
"CALPONIN"
] | [
5206
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-6798695",
"R-HSA-6798695",
"R-HSA-8950505",
"R-HSA-9927432",
"R-MMU-6798695"
] | [
"REACTOME:R-BTA-6798695",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-8950505",
"REACTOME:R-HSA-9927432",
"REACTOME:R-MMU-6798695"
] | 5 | [
"1h67",
"1wyn",
"1wyp"
] | 3 | [
"PUB00001664",
"PUB00002836",
"PUB00002979"
] | [
"8370452",
"8144658",
"8550594"
] | [
"Mammalian calponin. Identification and expression of genetic variants.",
"Cloning and expression of a novel acidic calponin isoform from rat aortic vascular smooth muscle.",
"Developmental pattern of expression and genomic organization of the calponin-h1 gene. A contractile smooth muscle cell marker."
] | [
1993,
1994,
1996
] | 3 | [
"IPR003096"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"bird metagenome"
] | [
2,
5203,
1
] | 3 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
20,
1,
26,
18,
21
] | 5 | true | Family | Calponin/LIMCH1 | Calponin/LIMCH1 | Calponin/LIMCH1 | 5 |
IPR001998 | 1,998 | Xylose isomerase | Xylose_isomerase | Family | 13,237 | false | false | Xylose isomerase ( ) [ ] is an enzyme found in microorganisms which catalyzes the interconversion of D-xylose to D-xylulose. It can also isomerize D-ribose to D-ribulose and D-glucose to D-fructose. The enzyme is a homotetramer, which is stabilised by cobalt, and requires magnesium for its catalytic activity. Each subu... | [
"GO:0009045",
"GO:0005975"
] | [
"xylose isomerase activity",
"carbohydrate metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"PRINTS",
"PROFILE",
"PANTHER"
] | [
"MF_00455",
"PR00688",
"PS51415",
"PTHR48408"
] | [
"Xylose_isom_A",
"XYLOSISMRASE",
"XYLOSE_ISOMERASE",
""
] | [
11189,
12282,
13173,
11689
] | 4 | [
"EC",
"PROSITEDOC"
] | [
"5.3.1.5",
"PDOC00156"
] | [
"EC:5.3.1.5",
"PROSITEDOC:PDOC00156"
] | 2 | [
"1a0c",
"1a0d",
"1a0e",
"1bhw",
"1bxb",
"1bxc",
"1clk",
"1did",
"1die",
"1dxi",
"1gw9",
"1mnz",
"1muw",
"1o1h",
"1oad",
"1qt1",
"1s5m",
"1s5n",
"1xib",
"1xic",
"1xid",
"1xie",
"1xif",
"1xig",
"1xih",
"1xii",
"1xij",
"1xim",
"1xin",
"1xis",
"1xla",
"1xlb"... | 208 | [
"PUB00001465",
"PUB00001569",
"PUB00003247"
] | [
"8620879",
"2651156",
"2769749"
] | [
"Protein purification, and cloning and characterization of the cDNA and gene for xylose isomerase of barley.",
"Crystallisation and preliminary analysis of glucose isomerase from Streptomyces albus.",
"Structures of D-xylose isomerase from Arthrobacter strain B3728 containing the inhibitors xylitol and D-sorbit... | [
1996,
1989,
1989
] | 3 | [] | [
"IPR013452",
"IPR013453"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
14,
11548,
1494,
181
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
9,
1,
4,
42
] | 4 | true | Family | Xylose isomerase | Xylose isomerase | Xylose_isomerase | 2 |
IPR001999 | 1,999 | Osteonectin-like, conserved site | Osteonectin_CS | Conserved_site | 2,659 | false | false | The osteonectin like domain, of unknown function, is found in extracellular proteins strongly expressed in tissues undergoing morphogenesis. It is a 240 amino acids domain, highly conserved, localised in the C-terminal part of the protein [ ]. This domain has a N-terminal section of about 90 residues that contains 11 c... | [
"GO:0005615"
] | [
"extracellular space"
] | [
"cellular_component"
] | 1 | [
"PROSITE",
"PROSITE"
] | [
"PS00612",
"PS00613"
] | [
"OSTEONECTIN_1",
"OSTEONECTIN_2"
] | [
2094,
2596
] | 2 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00535",
"R-BTA-114608",
"R-BTA-3000178",
"R-BTA-3000497",
"R-CEL-114608",
"R-CEL-3000178",
"R-CEL-381426",
"R-CEL-8957275",
"R-HSA-114608",
"R-HSA-1251985",
"R-HSA-3000178",
"R-HSA-3000497",
"R-HSA-381426",
"R-HSA-8957275",
"R-MMU-114608",
"R-MMU-3000178",
"R-MMU-3000497",
"R-... | [
"PROSITEDOC:PDOC00535",
"REACTOME:R-BTA-114608",
"REACTOME:R-BTA-3000178",
"REACTOME:R-BTA-3000497",
"REACTOME:R-CEL-114608",
"REACTOME:R-CEL-3000178",
"REACTOME:R-CEL-381426",
"REACTOME:R-CEL-8957275",
"REACTOME:R-HSA-114608",
"REACTOME:R-HSA-1251985",
"REACTOME:R-HSA-3000178",
"REACTOME:R-HS... | 27 | [
"1bmo",
"1nub",
"1sra",
"2v53",
"7kbu"
] | 5 | [
"PUB00001526",
"PUB00003931"
] | [
"8119487",
"8548457"
] | [
"The biology of SPARC, a protein that modulates cell-matrix interactions.",
"Structure of a novel extracellular Ca(2+)-binding module in BM-40."
] | [
1994,
1996
] | 2 | [] | [] | 0 | 0 | null | [
"Kangiella spongicola",
"Opisthokonta"
] | [
1,
2658
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
4,
1,
14,
9,
12
] | 6 | true | Conserved_site | Osteonectin-like, conserved site | Osteonectin-like, conserved site | Osteonectin_CS | 6 |
IPR002000 | 2,000 | Lysosome-associated membrane glycoprotein | Lysosome-assoc_membr_glycop | Family | 6,740 | false | false | Lysosome-associated membrane glycoproteins (lamp) [ ] are integral membrane proteins, specific to lysosomes, and whose exact biological function is not yet clear. Structurally, the lamp proteins consist of two internally homologous lysosome-luminal domains separated by a proline-rich hinge region; at the C-terminal ext... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PRINTS",
"PROFILE",
"PANTHER"
] | [
"PR00336",
"PS51407",
"PTHR11506"
] | [
"LYSASSOCTDMP",
"LAMP_3",
""
] | [
3722,
5267,
6632
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC00280",
"R-BTA-6798695",
"R-CEL-114608",
"R-CEL-6798695",
"R-HSA-114608",
"R-HSA-6798695",
"R-HSA-9613829",
"R-MMU-114608",
"R-MMU-6798695",
"R-RNO-114608",
"R-RNO-6798695"
] | [
"PROSITEDOC:PDOC00280",
"REACTOME:R-BTA-6798695",
"REACTOME:R-CEL-114608",
"REACTOME:R-CEL-6798695",
"REACTOME:R-HSA-114608",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-9613829",
"REACTOME:R-MMU-114608",
"REACTOME:R-MMU-6798695",
"REACTOME:R-RNO-114608",
"REACTOME:R-RNO-6798695"
] | 11 | [
"4akm",
"5gv0",
"5gv3",
"8ath",
"8fy5",
"8fyf"
] | 6 | [
"PUB00002666",
"PUB00002833",
"PUB00052605",
"PUB00052606"
] | [
"1939168",
"8486654",
"9768752",
"10862717"
] | [
"Lysosomal membrane glycoproteins. Structure, biosynthesis, and intracellular trafficking.",
"Macrosialin, a mouse macrophage-restricted glycoprotein, is a member of the lamp/lgp family.",
"A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC cl... | [
1991,
1993,
1998,
2000
] | 4 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
6740
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
16,
7,
22,
17,
29
] | 6 | true | Family | Lysosome-associated membrane glycoprotein | Lysosome-associated membrane glycoprotein | Lysosome-assoc_membr_glycop | 7 |
IPR002001 | 2,001 | GPCR, family 2, diuretic hormone receptor | GPCR_2_diuretic_rcpt | Family | 691 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0008036",
"GO:0016020"
] | [
"diuretic hormone receptor activity",
"membrane"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01127"
] | [
"DIUHORMONER"
] | [
691
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00001208",
"PUB00002036",
"PUB00002894",
"PUB00004310",
"PUB00004961",
"PUB00005147",
"PUB00005148",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816"
] | [
"1646711",
"8673074",
"8276884",
"1314625",
"8170923",
"1658940",
"1658941",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293"
] | [
"Molecular cloning and expression of a cDNA encoding the secretin receptor.",
"Molecular cloning and function expression of a diuretic hormone receptor from the house cricket, Acheta domesticus.",
"Expression cloning of an insect diuretic hormone receptor. A member of the calcitonin/secretin receptor family.",
... | [
1991,
1996,
1994,
1992,
1994,
1991,
1991,
2003,
1994,
2005,
2009,
2006,
2013
] | 13 | [
"IPR000832"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
691
] | 1 | [
"Drosophila melanogaster"
] | [
4
] | 1 | true | Family | GPCR, family 2, diuretic hormone receptor | GPCR, family 2, diuretic hormone receptor | GPCR_2_diuretic_rcpt | 3 |
IPR002002 | 2,002 | Octopamine receptor | Octopmn_rcpt | Family | 652 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0004989",
"GO:0007186",
"GO:0016020"
] | [
"octopamine receptor activity",
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR00664"
] | [
"OCTOPAMINER"
] | [
652
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-390696",
"R-CEL-392023",
"R-CEL-400042",
"R-CEL-418594",
"R-CEL-418597",
"R-DME-390696",
"R-DME-392023",
"R-DME-400042",
"R-DME-418594",
"R-DME-418597"
] | [
"REACTOME:R-CEL-390696",
"REACTOME:R-CEL-392023",
"REACTOME:R-CEL-400042",
"REACTOME:R-CEL-418594",
"REACTOME:R-CEL-418597",
"REACTOME:R-DME-390696",
"REACTOME:R-DME-392023",
"REACTOME:R-DME-400042",
"REACTOME:R-DME-418594",
"REACTOME:R-DME-418597"
] | 10 | [] | 0 | [
"PUB00000131",
"PUB00001197",
"PUB00002477",
"PUB00004304",
"PUB00004960",
"PUB00004961",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816"
] | [
"2111655",
"2170118",
"2830256",
"2156539",
"8386361",
"8170923",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293"
] | [
"G proteins in signal transduction.",
"Cloning and characterization of a Drosophila tyramine receptor.",
"G protein involvement in receptor-effector coupling.",
"Cloning, localization, and permanent expression of a Drosophila octopamine receptor.",
"Design of a discriminating fingerprint for G-protein-coupl... | [
1990,
1990,
1988,
1990,
1993,
1994,
2003,
1994,
2005,
2009,
2006,
2013
] | 12 | [
"IPR000276"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
652
] | 1 | [
"Caenorhabditis elegans",
"Drosophila melanogaster"
] | [
4,
2
] | 2 | true | Family | Octopamine receptor | Octopamine receptor | Octopmn_rcpt | 6 |
IPR002003 | 2,003 | Gas vesicle protein GvpC | Gas-vesicle_GvpC | Repeat | 228 | false | false | Gas vesicles are small, hollow, gas filled protein structures found in several cyanobacterial and archaebacterial microorganisms [ ]. They allow the positioning of the bacteria at the favorable depth for growth. Gas vesicles are hollow cylindrical tubes, closed by a hollow, conical cap at each end. Both the conical end... | [
"GO:0031412",
"GO:0031411"
] | [
"gas vesicle organization",
"gas vesicle"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"NCBIFAM"
] | [
"PF01304",
"TIGR02641"
] | [
"Gas_vesicle_C",
"gvpC_cyan_rpt"
] | [
153,
228
] | 2 | [
"GP",
"PROSITEDOC"
] | [
"GenProp0460",
"PDOC00208"
] | [
"GP:GenProp0460",
"PROSITEDOC:PDOC00208"
] | 2 | [] | 0 | [
"PUB00000481"
] | [
"2513809"
] | [
"Gas vesicle proteins."
] | [
1989
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"marine metagenome"
] | [
227,
1
] | 2 | [] | [] | 0 | true | Repeat | Gas vesicle protein GvpC | Gas vesicle protein GvpC | Gas-vesicle_GvpC | 9 |
IPR002004 | 2,004 | Polyadenylate-binding protein/Hyperplastic disc protein, C-terminal | PABP_HYD_C | Domain | 15,966 | false | false | The polyadenylate-binding protein (PABP) has a conserved C-terminal domain (PABC), which is also found in the hyperplastic discs protein (HYD) family of ubiquitin ligases that contain HECT domains ( ) [ ]. PABP recognises the 3' mRNA poly(A) tail and plays an essential role in eukaryotic translation initiation and mRNA... | [
"GO:0003723"
] | [
"RNA binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF00658",
"PS51309",
"SM00517"
] | [
"MLLE",
"PABC",
"PolyA"
] | [
15784,
15562,
15457
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-156827",
"R-BTA-429947",
"R-BTA-450408",
"R-BTA-72649",
"R-BTA-975956",
"R-BTA-975957",
"R-DDI-156827",
"R-DDI-450408",
"R-DDI-975956",
"R-DDI-975957",
"R-DRE-156827",
"R-DRE-450408",
"R-DRE-975956",
"R-DRE-975957",
"R-HSA-156827",
"R-HSA-429947",
"R-HSA-450408",
"R-HSA-7264... | [
"REACTOME:R-BTA-156827",
"REACTOME:R-BTA-429947",
"REACTOME:R-BTA-450408",
"REACTOME:R-BTA-72649",
"REACTOME:R-BTA-975956",
"REACTOME:R-BTA-975957",
"REACTOME:R-DDI-156827",
"REACTOME:R-DDI-450408",
"REACTOME:R-DDI-975956",
"REACTOME:R-DDI-975957",
"REACTOME:R-DRE-156827",
"REACTOME:R-DRE-4504... | 35 | [
"1g9l",
"1i2t",
"1ifw",
"1jgn",
"1jh4",
"1nmr",
"2dyd",
"2rqg",
"2rqh",
"2x04",
"3ktp",
"3ktr",
"3kui",
"3kuj",
"3kur",
"3kus",
"3kut",
"3ntw",
"3pkn",
"3pth",
"4ive",
"6h7a",
"6h7b",
"6r5k",
"7bn3",
"7pze",
"8bja",
"8c06",
"8c07",
"8d4x",
"8e0q",
"8ewi"... | 38 | [
"PUB00015091",
"PUB00015092"
] | [
"11287654",
"11940585"
] | [
"X-ray structure of the human hyperplastic discs protein: an ortholog of the C-terminal domain of poly(A)-binding protein.",
"Solution structure of the orphan PABC domain from Saccharomyces cerevisiae poly(A)-binding protein."
] | [
2001,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
11,
15944,
11
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
28,
4,
42,
5,
41,
21,
1,
22,
20,
1,
1,
42
] | 12 | true | Domain | Polyadenylate-binding protein/Hyperplastic disc protein, C-terminal | Polyadenylate-binding protein/Hyperplastic disc protein, C-terminal | PABP_HYD_C | 7 |
IPR002006 | 2,006 | Hepatitis core antigen | Hepatitis_core | Family | 24,018 | false | false | This entry represent the core antigen of the viral capsid (HBcAg) from various Hepatitis B virus (HBV), which is a major human pathogen. The virus is composed of an outer envelope of host-derived lipid containing the surface proteins, and an inner protein capsid that contains genomic DNA. The capsid is composed of a si... | [
"GO:0005198"
] | [
"structural molecule activity"
] | [
"molecular_function"
] | 1 | [
"HAMAP",
"PFAM"
] | [
"MF_04076",
"PF00906"
] | [
"HBV_HBEAG",
"Hepatitis_core"
] | [
8178,
24018
] | 2 | [] | [] | [] | 0 | [
"1qgt",
"2g33",
"2g34",
"2qij",
"3j2v",
"3kxs",
"3v6z",
"4bmg",
"4g93",
"5d7y",
"5e0i",
"5gmz",
"5t2p",
"5wre",
"5wtw",
"6bvf",
"6bvn",
"6cvk",
"6cwd",
"6cwt",
"6ecs",
"6edj",
"6htx",
"6hu4",
"6hu7",
"6j10",
"6t36",
"6tik",
"6ui6",
"6ui7",
"6vzp",
"6w0k"... | 86 | [
"PUB00030260"
] | [
"10394365"
] | [
"The crystal structure of the human hepatitis B virus capsid."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Hepadnaviridae",
"Opisthokonta"
] | [
24014,
4
] | 2 | [] | [] | 0 | true | Family | Hepatitis core antigen | Hepatitis core antigen | Hepatitis_core | 6 |
IPR002008 | 2,008 | DNA polymerase family X, beta-like | DNA_pol_X_beta-like | Family | 10,052 | false | false | DNA carries the biological information that instructs cells how to exist in an ordered fashion: accurate replication is thus one of the most important events in the cell life cycle. This function is mediated by DNA-directed DNA-polymerases, which add nucleotide triphosphate (dNTP) residues to the 3'-end of the growing ... | [
"GO:0003677",
"GO:0006281"
] | [
"DNA binding",
"DNA repair"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PRINTS"
] | [
"PR00870"
] | [
"DNAPOLXBETA"
] | [
10052
] | 1 | [
"EC",
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTO... | [
"2.7.7.7",
"4.2.99.-",
"PWY-5397",
"R-BTA-110362",
"R-BTA-110373",
"R-BTA-110381",
"R-BTA-5649702",
"R-BTA-5651801",
"R-BTA-5689880",
"R-BTA-73930",
"R-DRE-110362",
"R-DRE-110373",
"R-DRE-5649702",
"R-DRE-73930",
"R-HSA-110362",
"R-HSA-110373",
"R-HSA-110381",
"R-HSA-5649702",
"R... | [
"EC:2.7.7.7",
"EC:4.2.99.-",
"METACYC:PWY-5397",
"REACTOME:R-BTA-110362",
"REACTOME:R-BTA-110373",
"REACTOME:R-BTA-110381",
"REACTOME:R-BTA-5649702",
"REACTOME:R-BTA-5651801",
"REACTOME:R-BTA-5689880",
"REACTOME:R-BTA-73930",
"REACTOME:R-DRE-110362",
"REACTOME:R-DRE-110373",
"REACTOME:R-DRE-... | 38 | [
"1bpb",
"1bpd",
"1bpe",
"1bpx",
"1bpy",
"1bpz",
"1huo",
"1huz",
"1jn3",
"1mq2",
"1mq3",
"1nom",
"1rpl",
"1rzt",
"1tv9",
"1tva",
"1xsl",
"1xsn",
"1xsp",
"1zjm",
"1zjn",
"1zqa",
"1zqb",
"1zqc",
"1zqd",
"1zqe",
"1zqf",
"1zqg",
"1zqh",
"1zqi",
"1zqj",
"1zqk"... | 547 | [
"PUB00004647",
"PUB00004955"
] | [
"3479792",
"2196557"
] | [
"Bacteriophage PRD1 DNA polymerase: evolution of DNA polymerases.",
"An attempt to unify the structure of polymerases."
] | [
1987,
1990
] | 2 | [
"IPR022312"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
490,
2649,
6618,
66,
229
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (st... | [
5,
3,
22,
2,
2,
2,
7,
1,
1,
8
] | 10 | true | Family | DNA polymerase family X, beta-like | DNA polymerase family X, beta-like | DNA_pol_X_beta-like | 4 |
IPR002009 | 2,009 | Bromovirus coat protein | Bromo_CP | Family | 24 | false | false | null | [
"GO:0005198",
"GO:0019028"
] | [
"structural molecule activity",
"viral capsid"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF01318"
] | [
"Bromo_coat"
] | [
24
] | 1 | [] | [] | [] | 0 | [
"1cwp",
"1js9",
"1yc6",
"1za7",
"3j7l",
"3j7m",
"3j7n",
"6voc",
"7pe1",
"7pe2",
"8bi4",
"8c38",
"8cpy"
] | 13 | [
"PUB00005263"
] | [
"7743132"
] | [
"Structures of the native and swollen forms of cowpea chlorotic mottle virus determined by X-ray crystallography and cryo-electron microscopy."
] | [
1995
] | 1 | [] | [] | 0 | 0 | null | [
"Bromovirus"
] | [
24
] | 1 | [] | [] | 0 | true | Family | Bromovirus coat protein | Bromovirus coat protein | Bromo_CP | 1 |
IPR002010 | 2,010 | Type III secretion system inner membrane R protein | T3SS_IM_R | Family | 17,407 | false | false | Secretion of virulence factors in Gram-negative bacteria involves transportation of the protein across two membranes to reach the cell exterior [ ]. There have been four secretion systems described in animal enteropathogens such as Salmonella and Yersinia, with further sequence similarities in plant pathogens like Rals... | [
"GO:0006605",
"GO:0016020"
] | [
"protein targeting",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PRINTS",
"PANTHER"
] | [
"PF01311",
"PR00953",
"PTHR30065"
] | [
"Bac_export_1",
"TYPE3IMRPROT",
""
] | [
17403,
16913,
17120
] | 3 | [] | [] | [] | 0 | [
"6f2d",
"6pem",
"6pep",
"6q14",
"6q15",
"6q16",
"6r69",
"6r6b",
"6rwy",
"6s3l",
"6s3r",
"6s3s",
"7agx",
"7ah9",
"7ahi",
"7bin",
"7cgo",
"7e80",
"7nvg",
"8axk",
"8wk3",
"8wkk",
"8wkq",
"8wl2",
"8wlh",
"8wln",
"8wlq",
"8wlt",
"8wo5",
"8woe",
"8z5s",
"8z5u"... | 35 | [
"PUB00003585",
"PUB00007583",
"PUB00007897",
"PUB00007898"
] | [
"9618447",
"10564516",
"8969244",
"10334981"
] | [
"Type III protein secretion systems in bacterial pathogens of animals and plants.",
"Flagellar proteins and type III-exported virulence factors are the predominant proteins secreted into the culture media of Salmonella typhimurium.",
"Molecular mechanisms of bacterial virulence: type III secretion and pathogeni... | [
1998,
1999,
1996,
1999
] | 4 | [] | [
"IPR006303",
"IPR006304"
] | 0 | 2 | 0 | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
17208,
18,
181
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Type III secretion system inner membrane R protein | Type III secretion system inner membrane R protein | T3SS_IM_R | 4 |
IPR002011 | 2,011 | Tyrosine-protein kinase, receptor class II, conserved site | Tyr_kinase_rcpt_2_CS | Conserved_site | 17,564 | false | false | Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substra... | [
"GO:0004714",
"GO:0005524",
"GO:0006468",
"GO:0007169",
"GO:0016020"
] | [
"transmembrane receptor protein tyrosine kinase activity",
"ATP binding",
"protein phosphorylation",
"cell surface receptor protein tyrosine kinase signaling pathway",
"membrane"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 5 | [
"PROSITE"
] | [
"PS00239"
] | [
"RECEPTOR_TYR_KIN_II"
] | [
17564
] | 1 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.10.1",
"PDOC00212",
"R-DME-110478",
"R-DME-5140745",
"R-DME-77387",
"R-DME-9009391",
"R-DRE-201556",
"R-DRE-9842663",
"R-DRE-9851151",
"R-GGA-1257604",
"R-GGA-388844",
"R-GGA-6811558",
"R-GGA-9026527",
"R-GGA-9028731",
"R-GGA-9032759",
"R-GGA-9034013",
"R-GGA-9034793",
"R-GGA-... | [
"EC:2.7.10.1",
"PROSITEDOC:PDOC00212",
"REACTOME:R-DME-110478",
"REACTOME:R-DME-5140745",
"REACTOME:R-DME-77387",
"REACTOME:R-DME-9009391",
"REACTOME:R-DRE-201556",
"REACTOME:R-DRE-9842663",
"REACTOME:R-DRE-9851151",
"REACTOME:R-GGA-1257604",
"REACTOME:R-GGA-388844",
"REACTOME:R-GGA-6811558",
... | 122 | [
"1g1f",
"1gag",
"1i44",
"1ir3",
"1irk",
"1jqh",
"1k3a",
"1m7n",
"1p14",
"1p4o",
"1rqq",
"2auh",
"2b4s",
"2oj9",
"2xb7",
"2xba",
"2xp2",
"2yfx",
"2yhv",
"2yjr",
"2yjs",
"2z8c",
"2zm3",
"3aox",
"3bu3",
"3bu5",
"3bu6",
"3d94",
"3ekk",
"3ekn",
"3eta",
"3f5p"... | 265 | [
"PUB00000055",
"PUB00005115",
"PUB00015362",
"PUB00020114",
"PUB00034898",
"PUB00034899",
"PUB00052410",
"PUB00052411",
"PUB00052412"
] | [
"3052279",
"3291115",
"12368087",
"12471243",
"15078142",
"15320712",
"19275641",
"16700535",
"15845350"
] | [
"Growth factor receptor tyrosine kinases.",
"The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.",
"Evolution of protein kinase signaling from yeast to man.",
"The protein kinase complement of the human genome.",
"High-throughput structural biology in drug discovery... | [
1988,
1988,
2002,
2002,
2004,
2004,
2009,
2006,
2005
] | 9 | [] | [] | 0 | 0 | null | [
"Archaeoglobus fulgidus",
"Bacteria",
"Eukaryota",
"UR2 avian sarcoma virus"
] | [
3,
12,
17548,
1
] | 4 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
77,
42,
89,
25,
40
] | 5 | true | Conserved_site | Tyrosine-protein kinase, receptor class II, conserved site | Tyrosine-protein kinase, receptor class II, conserved site | Tyr_kinase_rcpt_2_CS | 9 |
IPR002013 | 2,013 | SAC domain | SAC_dom | Domain | 28,957 | false | false | The Sac domain is a region of homology between the N terminus of synaptojanin and the otherwise unrelated yeast protein Sac1p. The Sac domain is approximately 400 residues in length, and proteins containing this domain show approximately 35% identity with other Sac domains throughout this region. The Sac domain exhibit... | [
"GO:0016791"
] | [
"phosphatase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE"
] | [
"PF02383",
"PS50275"
] | [
"Syja_N",
"SAC"
] | [
28058,
27505
] | 2 | [
"EC",
"GP",
"GP",
"GP",
"GP",
"GP",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.1.3",
"GenProp1229",
"GenProp1395",
"GenProp1509",
"GenProp1605",
"GenProp1758",
"PDOC50275",
"R-BTA-1483248",
"R-BTA-1660514",
"R-CEL-1660499",
"R-CEL-1855183",
"R-CEL-1855204",
"R-CEL-8856828",
"R-DDI-1483248",
"R-DDI-1660514",
"R-DDI-1660516",
"R-DME-1483248",
"R-DME-1660514"... | [
"EC:3.1.3",
"GP:GenProp1229",
"GP:GenProp1395",
"GP:GenProp1509",
"GP:GenProp1605",
"GP:GenProp1758",
"PROSITEDOC:PDOC50275",
"REACTOME:R-BTA-1483248",
"REACTOME:R-BTA-1660514",
"REACTOME:R-CEL-1660499",
"REACTOME:R-CEL-1855183",
"REACTOME:R-CEL-1855204",
"REACTOME:R-CEL-8856828",
"REACTOM... | 54 | [
"3lwt",
"4tu3",
"7k1w",
"8c81"
] | 4 | [
"PUB00018232"
] | [
"11413010"
] | [
"The Sac phosphatase domain."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanocrinis",
"marine sediment metagenome"
] | [
37,
28917,
2,
1
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
49,
5,
60,
11,
65,
22,
4,
37,
40,
5,
5,
169
] | 12 | true | Domain | SAC domain | SAC domain | SAC_dom | 8 |
IPR002014 | 2,014 | VHS domain | VHS_dom | Domain | 33,042 | false | false | The VHS domain is an about 150 residues long domain, whose name is derived from its occurrence in VPS-27, Hrs and STAM. The VHS domain is found at the N- termini of proteins associated with endocytocis and/or vesicular trafficking, often in association with other domains like FYVE, SH3 or TAM [ , ]. The VHS domain of H... | [
"GO:0035091",
"GO:0043130"
] | [
"phosphatidylinositol binding",
"ubiquitin binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF00790",
"PS50179",
"SM00288"
] | [
"VHS",
"VHS",
"VHS"
] | [
29574,
32957,
29177
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC50179",
"R-BTA-182971",
"R-BTA-432720",
"R-BTA-5689880",
"R-BTA-6807004",
"R-BTA-8856825",
"R-BTA-8856828",
"R-BTA-9013420",
"R-BTA-917729",
"R-BTA-9706019",
"R-CEL-182971",
"R-CEL-6807004",
"R-CEL-8856825",
"R-CEL-8856828",
"R-CEL-9013420",
"R-CEL-917729",
"R-DME-182971",
"R-... | [
"PROSITEDOC:PDOC50179",
"REACTOME:R-BTA-182971",
"REACTOME:R-BTA-432720",
"REACTOME:R-BTA-5689880",
"REACTOME:R-BTA-6807004",
"REACTOME:R-BTA-8856825",
"REACTOME:R-BTA-8856828",
"REACTOME:R-BTA-9013420",
"REACTOME:R-BTA-917729",
"REACTOME:R-BTA-9706019",
"REACTOME:R-CEL-182971",
"REACTOME:R-CE... | 67 | [
"1dvp",
"1elk",
"1jpl",
"1juq",
"1jwf",
"1jwg",
"1lf8",
"1mhq",
"1py1",
"1ujj",
"1ujk",
"1vdy",
"1x5b",
"2dcp",
"2l0t",
"3g2s",
"3g2t",
"3g2u",
"3g2v",
"3g2w",
"3ldz",
"3rru",
"3zyq",
"4avx",
"9rdc"
] | 25 | [
"PUB00008037",
"PUB00008038",
"PUB00018177",
"PUB00018178"
] | [
"10985773",
"10693761",
"9600884",
"9872381"
] | [
"Structure of the VHS domain of human Tom1 (target of myb 1): insights into interactions with proteins and membranes.",
"Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction.",
"SMART, a simple modular architecture research tool: identif... | [
2000,
2000,
1998,
1998
] | 4 | [] | [
"IPR027429",
"IPR046996",
"IPR047013",
"IPR047493",
"IPR047528"
] | 0 | 5 | 0 | [
"Bacteria",
"Eukaryota",
"Methanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM 10308 / V24 S)",
"Pithovirus LCPAC001",
"uncultured organism MedDCM-OCT-S01-C7"
] | [
65,
32974,
1,
1,
1
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
45,
5,
31,
8,
93,
35,
6,
31,
48,
4,
5,
101
] | 12 | true | Domain | VHS domain | VHS domain | VHS_dom | 8 |
IPR002015 | 2,015 | Proteasome/cyclosome repeat | Proteasome/cyclosome_rpt | Repeat | 12,638 | false | false | A weakly conserved repeat module of unknown function, which occurs in two regulatory subunits of the 26S-proteasome and in one subunit of the anaphase-promoting complex [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01851"
] | [
"PC_rep"
] | [
12638
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1169091",
"R-BTA-1234176",
"R-BTA-1236978",
"R-BTA-174084",
"R-BTA-174154",
"R-BTA-174178",
"R-BTA-174184",
"R-BTA-187577",
"R-BTA-195253",
"R-BTA-202424",
"R-BTA-2467813",
"R-BTA-2871837",
"R-BTA-349425",
"R-BTA-350562",
"R-BTA-382556",
"R-BTA-450408",
"R-BTA-4608870",
"R-B... | [
"REACTOME:R-BTA-1169091",
"REACTOME:R-BTA-1234176",
"REACTOME:R-BTA-1236978",
"REACTOME:R-BTA-174084",
"REACTOME:R-BTA-174154",
"REACTOME:R-BTA-174178",
"REACTOME:R-BTA-174184",
"REACTOME:R-BTA-187577",
"REACTOME:R-BTA-195253",
"REACTOME:R-BTA-202424",
"REACTOME:R-BTA-2467813",
"REACTOME:R-BTA... | 355 | [
"2n3t",
"2n3u",
"2n3v",
"2n3w",
"2nbw",
"3jco",
"3jcp",
"4ady",
"4cr2",
"4cr3",
"4cr4",
"5a5b",
"5gjq",
"5gjr",
"5l4k",
"5ln3",
"5m32",
"5mpb",
"5mpc",
"5mpd",
"5mpe",
"5t0c",
"5t0g",
"5t0h",
"5t0i",
"5t0j",
"5vfp",
"5vfq",
"5vfr",
"5vfs",
"5vft",
"5vfu"... | 126 | [
"PUB00005789"
] | [
"9204704"
] | [
"A repetitive sequence in subunits of the 26S proteasome and 20S cyclosome (anaphase-promoting complex)."
] | [
1997
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
12638
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
13,
2,
3,
4,
22,
18,
2,
23,
12,
2,
2,
37
] | 12 | true | Repeat | Proteasome/cyclosome repeat | Proteasome/cyclosome repeat | Proteasome/cyclosome_rpt | 4 |
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