interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR003940 | 3,940 | Transforming growth factor beta-2 proprotein | TGFb2 | Family | 1,275 | false | false | The transforming growth factors-beta constitute a family of multi-functional cytokines that regulate cell growth and differentiation [ ]. Many cells synthesise TGF-beta, and essentially all have specific receptors for this peptide [ ]. TGF-beta regulates the actions of many other peptide growth factors and determines a... | [
"GO:0005160"
] | [
"transforming growth factor beta receptor binding"
] | [
"molecular_function"
] | 1 | [
"PRINTS"
] | [
"PR01425"
] | [
"TGFBETA2"
] | [
1275
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-114608",
"R-BTA-2129379",
"R-BTA-2173789",
"R-BTA-9839389",
"R-HSA-114608",
"R-HSA-2129379",
"R-HSA-2173789",
"R-HSA-3000178",
"R-HSA-9839389",
"R-MMU-114608",
"R-MMU-2129379",
"R-MMU-2173789",
"R-MMU-9839389",
"R-RNO-114608",
"R-RNO-2129379",
"R-RNO-2173789",
"R-RNO-9839389"
... | [
"REACTOME:R-BTA-114608",
"REACTOME:R-BTA-2129379",
"REACTOME:R-BTA-2173789",
"REACTOME:R-BTA-9839389",
"REACTOME:R-HSA-114608",
"REACTOME:R-HSA-2129379",
"REACTOME:R-HSA-2173789",
"REACTOME:R-HSA-3000178",
"REACTOME:R-HSA-9839389",
"REACTOME:R-MMU-114608",
"REACTOME:R-MMU-2129379",
"REACTOME:R... | 17 | [
"8fxs",
"8fxv"
] | 2 | [
"PUB00005153",
"PUB00007611",
"PUB00007612",
"PUB00007613",
"PUB00007614"
] | [
"1631557",
"8424942",
"2879635",
"8819159",
"8679613"
] | [
"Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily.",
"Transforming growth factor beta 1: NMR signal assignments of the recombinant protein expressed and isotopically enriched using Chinese hamster ovary cells.",
"The transforming growth factor-beta system, a complex pa... | [
1992,
1993,
1987,
1996,
1996
] | 5 | [
"IPR016319"
] | [] | 1 | 0 | 1 | [
"Vertebrata"
] | [
1275
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
5,
6,
5
] | 4 | true | Family | Transforming growth factor beta-2 proprotein | Transforming growth factor beta-2 proprotein | TGFb2 | 8 |
IPR003942 | 3,942 | Left- Right determination factor | LRDF | Family | 1,113 | false | false | Examples of lateral asymmetry are often found in vertebrates (e.g., the heart being on the left side), but the molecular mechanisms governing establishment of left-right (L-R) handedness are unknown [ ]. It is now thought that the gene lefty, a member of the transforming growth factor-beta family, may encode a morphoge... | [
"GO:0005160"
] | [
"transforming growth factor beta receptor binding"
] | [
"molecular_function"
] | 1 | [
"PIRSF",
"PRINTS"
] | [
"PIRSF037402",
"PR01427"
] | [
"TGFb4",
"TGFBETA4"
] | [
966,
1103
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-114608",
"R-HSA-1181150",
"R-HSA-1433617",
"R-MMU-114608"
] | [
"REACTOME:R-HSA-114608",
"REACTOME:R-HSA-1181150",
"REACTOME:R-HSA-1433617",
"REACTOME:R-MMU-114608"
] | 4 | [] | 0 | [
"PUB00007630",
"PUB00007631"
] | [
"9153275",
"8610011"
] | [
"Detection of ebaf, a novel human gene of the transforming growth factor beta superfamily association of gene expression with endometrial bleeding.",
"Left-right asymmetric expression of the TGF beta-family member lefty in mouse embryos."
] | [
1997,
1996
] | 2 | [
"IPR015615"
] | [] | 1 | 0 | 1 | [
"Deuterostomia"
] | [
1113
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
3,
3,
4
] | 4 | true | Family | Left- Right determination factor | Left- Right determination factor | LRDF | 5 |
IPR003943 | 3,943 | Protease-activated receptor 3 | Prot_act_rcpt_3 | Family | 776 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0015057",
"GO:0007596",
"GO:0070493",
"GO:0016020"
] | [
"thrombin-activated receptor activity",
"blood coagulation",
"thrombin-activated receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PRINTS"
] | [
"PR01429"
] | [
"PROTEASEAR3"
] | [
776
] | 1 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"349",
"R-HSA-375276",
"R-HSA-416476",
"R-HSA-456926",
"R-MMU-375276",
"R-MMU-416476",
"R-MMU-456926",
"R-RNO-375276",
"R-RNO-416476",
"R-RNO-456926"
] | [
"IUPHAR:349",
"REACTOME:R-HSA-375276",
"REACTOME:R-HSA-416476",
"REACTOME:R-HSA-456926",
"REACTOME:R-MMU-375276",
"REACTOME:R-MMU-416476",
"REACTOME:R-MMU-456926",
"REACTOME:R-RNO-375276",
"REACTOME:R-RNO-416476",
"REACTOME:R-RNO-456926"
] | 10 | [] | 0 | [
"PUB00000131",
"PUB00002477",
"PUB00002945",
"PUB00004960",
"PUB00004961",
"PUB00007615",
"PUB00007616",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816"
] | [
"2111655",
"2830256",
"7890726",
"8386361",
"8170923",
"9087410",
"8784787",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293"
] | [
"G proteins in signal transduction.",
"G protein involvement in receptor-effector coupling.",
"The mouse proteinase-activated receptor-2 cDNA and gene. Molecular cloning and functional expression.",
"Design of a discriminating fingerprint for G-protein-coupled receptors.",
"Fingerprinting G-protein-coupled ... | [
1990,
1988,
1995,
1993,
1994,
1997,
1996,
2003,
1994,
2005,
2009,
2006,
2013
] | 13 | [
"IPR003912"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
776
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
2,
2
] | 4 | true | Family | Protease-activated receptor 3 | Protease-activated receptor 3 | Prot_act_rcpt_3 | 6 |
IPR003944 | 3,944 | Protease-activated receptor 4 | Prot_act_rcpt_4 | Family | 841 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0015057",
"GO:0007596",
"GO:0070493",
"GO:0016020"
] | [
"thrombin-activated receptor activity",
"blood coagulation",
"thrombin-activated receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PRINTS"
] | [
"PR01430"
] | [
"PROTEASEAR4"
] | [
841
] | 1 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"350",
"R-HSA-375276",
"R-HSA-416476",
"R-HSA-456926",
"R-MMU-375276",
"R-MMU-416476",
"R-MMU-456926",
"R-RNO-375276",
"R-RNO-416476",
"R-RNO-456926"
] | [
"IUPHAR:350",
"REACTOME:R-HSA-375276",
"REACTOME:R-HSA-416476",
"REACTOME:R-HSA-456926",
"REACTOME:R-MMU-375276",
"REACTOME:R-MMU-416476",
"REACTOME:R-MMU-456926",
"REACTOME:R-RNO-375276",
"REACTOME:R-RNO-416476",
"REACTOME:R-RNO-456926"
] | 10 | [
"2pv9"
] | 1 | [
"PUB00000131",
"PUB00002477",
"PUB00002945",
"PUB00004960",
"PUB00004961",
"PUB00007615",
"PUB00007616",
"PUB00007632",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816"
] | [
"2111655",
"2830256",
"7890726",
"8386361",
"8170923",
"9087410",
"8784787",
"9618465",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293"
] | [
"G proteins in signal transduction.",
"G protein involvement in receptor-effector coupling.",
"The mouse proteinase-activated receptor-2 cDNA and gene. Molecular cloning and functional expression.",
"Design of a discriminating fingerprint for G-protein-coupled receptors.",
"Fingerprinting G-protein-coupled ... | [
1990,
1988,
1995,
1993,
1994,
1997,
1996,
1998,
2003,
1994,
2005,
2009,
2006,
2013
] | 14 | [
"IPR003912"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Opisthokonta"
] | [
2,
839
] | 2 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
4
] | 3 | true | Family | Protease-activated receptor 4 | Protease-activated receptor 4 | Prot_act_rcpt_4 | 7 |
IPR003945 | 3,945 | NADH-quinone oxidoreductase, chain 5-like | NU5C-like | Family | 118,271 | false | false | NADH-quinone oxidoreductase chain 5 is part of the NADH-ubiquinone oxidoreductase (complex I), which catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane [ ]: NADH + ubiquinone = NAD(+) + ubiquinol This family includes NAD(P)H-qui... | [
"GO:0008137",
"GO:0042773"
] | [
"NADH dehydrogenase (ubiquinone) activity",
"ATP synthesis coupled electron transport"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PANTHER"
] | [
"PTHR42829"
] | [
""
] | [
118271
] | 1 | [
"EC",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REA... | [
"7.1.1",
"GenProp0135",
"GenProp1198",
"GenProp1230",
"GenProp1254",
"GenProp1341",
"GenProp1537",
"GenProp1583",
"GenProp1608",
"GenProp1637",
"GenProp1751",
"R-CEL-5419276",
"R-DME-5419276",
"R-DME-611105",
"R-DME-6799198",
"R-DRE-611105",
"R-GGA-5419276",
"R-GGA-611105",
"R-GG... | [
"EC:7.1.1",
"GP:GenProp0135",
"GP:GenProp1198",
"GP:GenProp1230",
"GP:GenProp1254",
"GP:GenProp1341",
"GP:GenProp1537",
"GP:GenProp1583",
"GP:GenProp1608",
"GP:GenProp1637",
"GP:GenProp1751",
"REACTOME:R-CEL-5419276",
"REACTOME:R-DME-5419276",
"REACTOME:R-DME-611105",
"REACTOME:R-DME-679... | 32 | [
"3rko",
"4he8",
"4hea",
"4wz7",
"5gpn",
"5gup",
"5lc5",
"5ldw",
"5ldx",
"5lnk",
"5o31",
"5xtc",
"5xtd",
"5xth",
"5xti",
"6g2j",
"6g72",
"6gcs",
"6h8k",
"6hum",
"6i0d",
"6i1p",
"6khi",
"6khj",
"6l7o",
"6l7p",
"6nbq",
"6nbx",
"6nby",
"6q8o",
"6q8w",
"6q8x"... | 313 | [
"PUB00005074",
"PUB00093673",
"PUB00099647",
"PUB00099652"
] | [
"1470679",
"31406332",
"28911053",
"26286985"
] | [
"The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains.",
"DABs are inorganic carbon pumps found throughout prokaryotic phyla.",
"Co-ordination of NDH and Cup proteins in CO2 uptake in cyanobacterium Synechocystis sp. PCC 6803.",
"Why chloroplasts and mitochondria retain their own genomes and g... | [
1992,
2019,
2017,
2015
] | 4 | [] | [
"IPR010217",
"IPR018393",
"IPR046396"
] | 0 | 3 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
917,
23216,
93406,
732
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
19,
5,
1,
17,
2,
1688,
14,
2,
6,
10,
9
] | 11 | true | Family | NADH-quinone oxidoreductase, chain 5-like | NADH-quinone oxidoreductase, chain 5-like | NU5C-like | 8 |
IPR003947 | 3,947 | Potassium channel, voltage dependent, KCNQ2 | K_chnl_volt-dep_KCNQ2 | Family | 3,059 | false | false | Potassium channels are the most diverse group of the ion channel family [ , ]. They are important in shaping the action potential, and in neuronal excitability and plasticity [ ]. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups [ ]: the pr... | [
"GO:0005249",
"GO:0006813",
"GO:0016020"
] | [
"voltage-gated potassium channel activity",
"potassium ion transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01461"
] | [
"KCNQ2CHANNEL"
] | [
3059
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-1296072",
"R-HSA-445095"
] | [
"REACTOME:R-HSA-1296072",
"REACTOME:R-HSA-445095"
] | 2 | [
"7cr0",
"7cr1",
"7cr2",
"7cr3",
"7cr4",
"7cr7",
"8ijk",
"8izy",
"8j00",
"8j01",
"8j02",
"8j03",
"8j04",
"8j05",
"8w4u",
"8x43",
"8xo1",
"9ixy",
"9ixz"
] | 19 | [
"PUB00001055",
"PUB00001622",
"PUB00002771",
"PUB00004011",
"PUB00004020",
"PUB00006577",
"PUB00008295",
"PUB00008296",
"PUB00008297",
"PUB00008869",
"PUB00009378"
] | [
"1772658",
"1879548",
"1373731",
"2448635",
"2451788",
"2555158",
"10838601",
"8528244",
"9430594",
"9872318",
"11178249"
] | [
"The molecular biology of K+ channels.",
"Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.",
"Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.",
"Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso... | [
1991,
1991,
1992,
1988,
1988,
1989,
2000,
1996,
1998,
1998,
2000
] | 11 | [
"IPR003937"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
3059
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
19,
22,
11,
15
] | 4 | true | Family | Potassium channel, voltage dependent, KCNQ2 | Potassium channel, voltage dependent, KCNQ2 | K_chnl_volt-dep_KCNQ2 | 1 |
IPR003948 | 3,948 | Potassium channel, voltage dependent, KCNQ3 | K_chnl_volt-dep_KCNQ3 | Family | 1,058 | false | false | Potassium channels are the most diverse group of the ion channel family [ , ]. They are important in shaping the action potential, and in neuronal excitability and plasticity [ ]. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups [ ]: the pr... | [
"GO:0005249",
"GO:0006813",
"GO:0016020"
] | [
"voltage-gated potassium channel activity",
"potassium ion transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01462"
] | [
"KCNQ3CHANNEL"
] | [
1058
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-1296072",
"R-HSA-1296072",
"R-HSA-445095"
] | [
"REACTOME:R-BTA-1296072",
"REACTOME:R-HSA-1296072",
"REACTOME:R-HSA-445095"
] | 3 | [] | 0 | [
"PUB00001055",
"PUB00001622",
"PUB00002771",
"PUB00004011",
"PUB00004020",
"PUB00006577",
"PUB00008295",
"PUB00008296",
"PUB00008297",
"PUB00008869",
"PUB00009378"
] | [
"1772658",
"1879548",
"1373731",
"2448635",
"2451788",
"2555158",
"10838601",
"8528244",
"9430594",
"9872318",
"11178249"
] | [
"The molecular biology of K+ channels.",
"Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.",
"Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.",
"Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso... | [
1991,
1991,
1992,
1988,
1988,
1989,
2000,
1996,
1998,
1998,
2000
] | 11 | [
"IPR003937"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
1058
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
6,
2,
5
] | 4 | true | Family | Potassium channel, voltage dependent, KCNQ3 | Potassium channel, voltage dependent, KCNQ3 | K_chnl_volt-dep_KCNQ3 | 6 |
IPR003949 | 3,949 | Potassium channel, voltage-dependent, EAG | K_chnl_volt-dep_EAG | Family | 4,144 | false | false | Potassium channels are the most diverse group of the ion channel family [ , ]. They are important in shaping the action potential, and in neuronal excitability and plasticity [ ]. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups [ ]: the pr... | [
"GO:0005249",
"GO:0006813",
"GO:0016020"
] | [
"voltage-gated potassium channel activity",
"potassium ion transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01464"
] | [
"EAGCHANNEL"
] | [
4144
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-1296072",
"R-DME-1296072",
"R-HSA-1296072",
"R-MMU-1296072",
"R-RNO-1296072"
] | [
"REACTOME:R-BTA-1296072",
"REACTOME:R-DME-1296072",
"REACTOME:R-HSA-1296072",
"REACTOME:R-MMU-1296072",
"REACTOME:R-RNO-1296072"
] | 5 | [
"4f8a",
"4hoi",
"4llo",
"5j7e",
"5k7l",
"6pbx",
"6pby",
"7yid",
"7yie",
"7yif",
"7yig",
"7yih",
"7yij",
"8eow",
"8ep0",
"8ep1"
] | 16 | [
"PUB00001055",
"PUB00001622",
"PUB00002771",
"PUB00004011",
"PUB00004020",
"PUB00006577",
"PUB00007312",
"PUB00008879",
"PUB00009378"
] | [
"1772658",
"1879548",
"1373731",
"2448635",
"2451788",
"2555158",
"10798390",
"9524140",
"11178249"
] | [
"The molecular biology of K+ channels.",
"Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.",
"Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.",
"Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso... | [
1991,
1991,
1992,
1988,
1988,
1989,
2000,
1998,
2000
] | 9 | [
"IPR050818"
] | [] | 1 | 0 | 1 | [
"Eumetazoa"
] | [
4144
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
18,
9,
11,
6,
7
] | 6 | true | Family | Potassium channel, voltage-dependent, EAG | Potassium channel, voltage-dependent, EAG | K_chnl_volt-dep_EAG | 9 |
IPR003950 | 3,950 | Potassium channel, voltage-dependent, ELK | K_chnl_volt-dep_ELK | Family | 3,172 | false | false | Potassium channels are the most diverse group of the ion channel family [ , ]. They are important in shaping the action potential, and in neuronal excitability and plasticity [ ]. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups [ ]: the pr... | [
"GO:0005249",
"GO:0006813",
"GO:0016020"
] | [
"voltage-gated potassium channel activity",
"potassium ion transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01465"
] | [
"ELKCHANNEL"
] | [
3172
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1296072",
"R-MMU-1296072",
"R-RNO-1296072"
] | [
"REACTOME:R-HSA-1296072",
"REACTOME:R-MMU-1296072",
"REACTOME:R-RNO-1296072"
] | 3 | [] | 0 | [
"PUB00001055",
"PUB00001622",
"PUB00002771",
"PUB00004011",
"PUB00004020",
"PUB00006577",
"PUB00007312",
"PUB00008881",
"PUB00008882",
"PUB00009378"
] | [
"1772658",
"1879548",
"1373731",
"2448635",
"2451788",
"2555158",
"10798390",
"10455180",
"10191308",
"11178249"
] | [
"The molecular biology of K+ channels.",
"Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.",
"Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.",
"Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso... | [
1991,
1991,
1992,
1988,
1988,
1989,
2000,
1999,
1999,
2000
] | 10 | [
"IPR050818"
] | [] | 1 | 0 | 1 | [
"Eumetazoa"
] | [
3172
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
19,
5,
5,
4,
10
] | 5 | true | Family | Potassium channel, voltage-dependent, ELK | Potassium channel, voltage-dependent, ELK | K_chnl_volt-dep_ELK | 1 |
IPR003951 | 3,951 | Peptidase C58, Yersinia/Haemophilus virulence surface antigen | Peptidase_C58 | Family | 96 | false | false | This group of cysteine peptidases correspond to MEROPS peptidase family C58 (clan CA). They are found in bacteria that include plant pathogens (Pseudomonas syringae), root nodule bacteria, and intracellular pathogens (e.g. Yersinia pestis, Haemophilus ducreyi, Pasteurella multocida, Chlamydia trachomatis) of animal hos... | [
"GO:0004197"
] | [
"cysteine-type endopeptidase activity"
] | [
"molecular_function"
] | 1 | [
"PRINTS"
] | [
"PR01376"
] | [
"BACSURFANTGN"
] | [
96
] | 1 | [
"EC"
] | [
"3.4.22.-"
] | [
"EC:3.4.22.-"
] | 1 | [
"6u8t"
] | 1 | [
"PUB00003585",
"PUB00008886",
"PUB00009736",
"PUB00011704",
"PUB00020025",
"PUB00030423",
"PUB00076953"
] | [
"9618447",
"9746557",
"12062101",
"11517925",
"9891971",
"14725770",
"7044372"
] | [
"Type III protein secretion systems in bacterial pathogens of animals and plants.",
"DNA sequencing and analysis of the low-Ca2+-response plasmid pCD1 of Yersinia pestis KIM5.",
"A Yersinia effector and a Pseudomonas avirulence protein define a family of cysteine proteases functioning in bacterial pathogenesis.... | [
1998,
1998,
2002,
2001,
1998,
2004,
1982
] | 7 | [] | [] | 0 | 0 | null | [
"Pseudomonadota"
] | [
96
] | 1 | [] | [] | 0 | true | Family | Peptidase C58, Yersinia/Haemophilus virulence surface antigen | Peptidase C58, Yersinia/Haemophilus virulence surface antigen | Peptidase_C58 | 5 |
IPR003952 | 3,952 | Fumarate reductase/succinate dehydrogenase, FAD-binding site | FRD_SDH_FAD_BS | Binding_site | 23,852 | false | false | In bacteria two distinct, membrane-bound, enzyme complexes are responsible for the interconversion of fumarate and succinate ( ): fumarate reductase (Frd) is used in anaerobic growth, and succinate dehydrogenase (Sdh) is used in aerobic growth. Both complexes consist of two main components: a membrane-extrinsic compone... | [
"GO:0016491"
] | [
"oxidoreductase activity"
] | [
"molecular_function"
] | 1 | [
"PROSITE"
] | [
"PS00504"
] | [
"FRD_SDH_FAD_BINDING"
] | [
23852
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"... | [
"1.3.5.1",
"PWY-3781",
"PWY-4302",
"PWY-5392",
"PWY-561",
"PWY-5690",
"PWY-5913",
"PWY-6728",
"PWY-6969",
"PWY-7254",
"PWY-7279",
"PWY-7384",
"PWY-8086",
"PDOC00393",
"R-CEL-71403",
"R-CEL-9854311",
"R-DDI-71403",
"R-DDI-9854311",
"R-DME-71403",
"R-DME-9854311",
"R-DRE-71403"... | [
"EC:1.3.5.1",
"METACYC:PWY-3781",
"METACYC:PWY-4302",
"METACYC:PWY-5392",
"METACYC:PWY-561",
"METACYC:PWY-5690",
"METACYC:PWY-5913",
"METACYC:PWY-6728",
"METACYC:PWY-6969",
"METACYC:PWY-7254",
"METACYC:PWY-7279",
"METACYC:PWY-7384",
"METACYC:PWY-8086",
"PROSITEDOC:PDOC00393",
"REACTOME:R... | 38 | [
"1e7p",
"1kf6",
"1kfy",
"1l0v",
"1nek",
"1nen",
"1qlb",
"1yq3",
"1yq4",
"1zoy",
"1zp0",
"2acz",
"2b76",
"2bs2",
"2bs3",
"2bs4",
"2fbw",
"2h88",
"2h89",
"2wdq",
"2wdr",
"2wdv",
"2wp9",
"2wqy",
"2ws3",
"2wu2",
"2wu5",
"3abv",
"3ae1",
"3ae2",
"3ae3",
"3ae4"... | 97 | [
"PUB00002503",
"PUB00002711"
] | [
"2668268",
"1375942"
] | [
"Fumarate reductase mutants of Escherichia coli that lack covalently bound flavin.",
"The sequence of the flavoprotein subunit of bovine heart succinate dehydrogenase."
] | [
1989,
1992
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
542,
17601,
5460,
249
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
6,
2,
2,
4,
2,
5,
2,
1,
2,
4,
2,
1,
9
] | 13 | true | Binding_site | Fumarate reductase/succinate dehydrogenase, FAD-binding site | Fumarate reductase/succinate dehydrogenase, FAD-binding site | FRD_SDH_FAD_BS | 1 |
IPR003953 | 3,953 | FAD-dependent oxidoreductase 2, FAD-binding domain | FAD-dep_OxRdtase_2_FAD-bd | Domain | 112,138 | false | false | This domain is found in proteins that bind FAD, mainly in FAD-dependent oxidoreductase family 2 proteins, such as the flavoprotein subunits from succinate and fumarate dehydrogenase, and aspartate oxidase [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF00890"
] | [
"FAD_binding_2"
] | [
112138
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-71403",
"R-CEL-9854311",
"R-DDI-71403",
"R-DDI-9854311",
"R-DME-71403",
"R-DME-9854311",
"R-DRE-71403",
"R-DRE-9854311",
"R-GGA-372987",
"R-HSA-611105",
"R-HSA-71403",
"R-HSA-9854311",
"R-MMU-71403",
"R-MMU-9854311",
"R-RNO-71403",
"R-RNO-9854311",
"R-SCE-71403",
"R-SCE-9854... | [
"REACTOME:R-CEL-71403",
"REACTOME:R-CEL-9854311",
"REACTOME:R-DDI-71403",
"REACTOME:R-DDI-9854311",
"REACTOME:R-DME-71403",
"REACTOME:R-DME-9854311",
"REACTOME:R-DRE-71403",
"REACTOME:R-DRE-9854311",
"REACTOME:R-GGA-372987",
"REACTOME:R-HSA-611105",
"REACTOME:R-HSA-71403",
"REACTOME:R-HSA-9854... | 24 | [
"1chu",
"1d4c",
"1d4d",
"1d4e",
"1e39",
"1e7p",
"1jnr",
"1jnz",
"1jrx",
"1jry",
"1jrz",
"1kf6",
"1kfy",
"1knp",
"1knr",
"1kss",
"1ksu",
"1l0v",
"1lj1",
"1m64",
"1nek",
"1nen",
"1p2e",
"1p2h",
"1q9i",
"1qjd",
"1qlb",
"1qo8",
"1y0p",
"1yq3",
"1yq4",
"1zoy"... | 169 | [
"PUB00005021"
] | [
"8061609"
] | [
"Structure of glutathione reductase from Escherichia coli at 1.86 A resolution: comparison with the enzyme from human erythrocytes."
] | [
1994
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
2530,
89663,
17874,
3,
2068
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
21,
3,
3,
2,
4,
11,
3,
9,
21,
4,
4,
2,
41
] | 13 | true | Domain | FAD-dependent oxidoreductase 2, FAD-binding domain | FAD-dependent oxidoreductase 2, FAD-binding domain | FAD-dep_OxRdtase_2_FAD-bd | 1 |
IPR003954 | 3,954 | RNA recognition motif domain, eukaryotic-type | RRM_euk-type | Domain | 60,194 | false | false | Many eukaryotic proteins that are known or supposed to bind single-stranded RNA contain one or more copies of a putative RNA-binding domain of about 90 amino acids. This is known as the eukaryotic putative RNA-binding region RNP-1 motif [ , ], or RNA recognition motif (RRM). RRMs are found in a variety of RNA binding p... | [
"GO:0003676"
] | [
"nucleic acid binding"
] | [
"molecular_function"
] | 1 | [
"SMART"
] | [
"SM00361"
] | [
"RRM_1"
] | [
60194
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-156827",
"R-BTA-159236",
"R-BTA-429947",
"R-BTA-450408",
"R-BTA-72163",
"R-BTA-72165",
"R-BTA-72187",
"R-BTA-72203",
"R-BTA-72649",
"R-BTA-73856",
"R-BTA-975956",
"R-BTA-975957",
"R-CEL-72163",
"R-DDI-156827",
"R-DDI-450408",
"R-DDI-975956",
"R-DDI-975957",
"R-DME-159236",
... | [
"REACTOME:R-BTA-156827",
"REACTOME:R-BTA-159236",
"REACTOME:R-BTA-429947",
"REACTOME:R-BTA-450408",
"REACTOME:R-BTA-72163",
"REACTOME:R-BTA-72165",
"REACTOME:R-BTA-72187",
"REACTOME:R-BTA-72203",
"REACTOME:R-BTA-72649",
"REACTOME:R-BTA-73856",
"REACTOME:R-BTA-975956",
"REACTOME:R-BTA-975957",
... | 120 | [
"1jmt",
"1x5s",
"2cpi",
"2dny",
"2e5h",
"2kn4",
"2lea",
"2leb",
"2lec",
"2mb0",
"2mjn",
"2mks",
"2pe8",
"2peh",
"3dxb",
"3md3",
"3ue2",
"3us5",
"4yh8",
"5lso",
"5tbx",
"6hip",
"6lur",
"6r5k",
"6slo",
"7c06",
"7c07",
"7c08",
"9cb5"
] | 29 | [
"PUB00001891",
"PUB00004440",
"PUB00005341"
] | [
"2470643",
"8290338",
"3072706"
] | [
"RNA-binding proteins as developmental regulators.",
"Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors.",
"Heterogeneous nuclear ribonucleoprotein particles and the pathway of mRNA formation."
] | [
1989,
1993,
1988
] | 3 | [
"IPR000504"
] | [
"IPR034653",
"IPR034827",
"IPR034830"
] | 1 | 3 | 0 | [
"Bacteria",
"Eukaryota",
"Methanofollis formosanus",
"ecological metagenomes"
] | [
258,
59932,
1,
3
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
96,
19,
77,
18,
107,
71,
4,
72,
87,
7,
6,
188
] | 12 | true | Domain | RNA recognition motif domain, eukaryotic-type | RNA recognition motif domain, eukaryotic-type | RRM_euk-type | 8 |
IPR003956 | 3,956 | Transcription factor, NFYB/HAP3, conserved site | Transcrpt_fac_NFYB/HAP3_CS | Conserved_site | 8,651 | false | false | The CCAAT-binding factor (CBF, of NFY) is a mammalian transcription factor that binds to a CCAAT motif in the promoters of a wide variety of genes, including type I collagen and albumin. The factor is a heteromeric complex of A and B subunits, both of which are required for DNA-binding [ , ]. The subunits can interact ... | [
"GO:0043565",
"GO:0006355",
"GO:0005634"
] | [
"sequence-specific DNA binding",
"regulation of DNA-templated transcription",
"nucleus"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PROSITE"
] | [
"PS00685"
] | [
"NFYB_HAP3"
] | [
8651
] | 1 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC00578",
"R-HSA-1989781",
"R-HSA-2426168",
"R-HSA-380994",
"R-HSA-381183",
"R-HSA-9614657"
] | [
"PROSITEDOC:PDOC00578",
"REACTOME:R-HSA-1989781",
"REACTOME:R-HSA-2426168",
"REACTOME:R-HSA-380994",
"REACTOME:R-HSA-381183",
"REACTOME:R-HSA-9614657"
] | 6 | [
"1n1j",
"4awl",
"4csr",
"4g91",
"4g92",
"5g49",
"6qmp",
"6qmq",
"6qms",
"6r0l",
"6r0m",
"6r0n",
"6r2v",
"6y35",
"6y36",
"6y37",
"6y39",
"7ah8",
"7aw7",
"7aw9",
"7c9o",
"7c9p",
"7cvo",
"7cvq",
"8qu2",
"8qu3",
"8qu4"
] | 27 | [
"PUB00002598",
"PUB00003767",
"PUB00004401"
] | [
"2266139",
"7845362",
"1549471"
] | [
"Purification and molecular cloning of the \"A\" chain of a rat heteromeric CCAAT-binding protein. Sequence identity with the yeast HAP3 transcription factor.",
"Sequence of the HAP3 transcription factor of Kluyveromyces lactis predicts the presence of a novel 4-cysteine zinc-finger motif.",
"Evolutionary varia... | [
1990,
1994,
1992
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
8651
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (st... | [
44,
12,
2,
5,
2,
28,
6,
1,
1,
50
] | 10 | true | Conserved_site | Transcription factor, NFYB/HAP3, conserved site | Transcription factor, NFYB/HAP3, conserved site | Transcrpt_fac_NFYB/HAP3_CS | 3 |
IPR003958 | 3,958 | Transcription factor CBF/NF-Y/archaeal histone domain | CBFA_NFYB_domain | Domain | 34,135 | false | false | This domain is found in archaebacterial histones and histone-like transcription factors from eukaryotes. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF00808"
] | [
"CBFD_NFYB_HMF"
] | [
34135
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-110314",
"R-BTA-5651801",
"R-BTA-5656169",
"R-BTA-5685942",
"R-BTA-5696397",
"R-BTA-5696400",
"R-BTA-6782135",
"R-BTA-6782210",
"R-BTA-68952",
"R-BTA-68962",
"R-DDI-110314",
"R-DDI-5651801",
"R-DDI-5656169",
"R-DDI-5696397",
"R-DDI-6782135",
"R-DDI-6782210",
"R-DDI-68952",
"... | [
"REACTOME:R-BTA-110314",
"REACTOME:R-BTA-5651801",
"REACTOME:R-BTA-5656169",
"REACTOME:R-BTA-5685942",
"REACTOME:R-BTA-5696397",
"REACTOME:R-BTA-5696400",
"REACTOME:R-BTA-6782135",
"REACTOME:R-BTA-6782210",
"REACTOME:R-BTA-68952",
"REACTOME:R-BTA-68962",
"REACTOME:R-DDI-110314",
"REACTOME:R-DD... | 76 | [
"1a7w",
"1b67",
"1b6w",
"1bfm",
"1f1e",
"1hta",
"1jfi",
"1ku5",
"1n1j",
"2byk",
"2bym",
"4awl",
"4csr",
"4g91",
"4g92",
"4wzs",
"5g49",
"5t5k",
"5y26",
"5y27",
"6qmp",
"6qmq",
"6qms",
"6r0l",
"6r0m",
"6r0n",
"6r2v",
"6y35",
"6y36",
"6y37",
"6y39",
"7ah8"... | 50 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
1119,
12,
32926,
15,
63
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
97,
7,
20,
10,
13,
21,
7,
55,
23,
3,
6,
119
] | 12 | true | Domain | Transcription factor CBF/NF-Y/archaeal histone domain | Transcription factor CBF/NF-Y/archaeal histone domain | CBFA_NFYB_domain | 9 |
IPR003959 | 3,959 | ATPase, AAA-type, core | ATPase_AAA_core | Domain | 584,677 | false | false | AAA ATPases (ATPases Associated with diverse cellular Activities) form a large protein family and play a number of roles in the cell including cell-cycle regulation, protein proteolysis and disaggregation, organelle biogenesis and intracellular transport. Some of them function as molecular chaperones, subunits of prote... | [
"GO:0005524",
"GO:0016887"
] | [
"ATP binding",
"ATP hydrolysis activity"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM",
"PFAM",
"PFAM"
] | [
"PF00004",
"PF07724",
"PF13304"
] | [
"AAA",
"AAA_2",
"AAA_21"
] | [
503120,
133386,
36151
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-110312",
"R-BTA-110314",
"R-BTA-110320",
"R-BTA-1169091",
"R-BTA-1234176",
"R-BTA-1236978",
"R-BTA-174084",
"R-BTA-174154",
"R-BTA-174178",
"R-BTA-174184",
"R-BTA-174411",
"R-BTA-176187",
"R-BTA-187577",
"R-BTA-195253",
"R-BTA-202424",
"R-BTA-2467813",
"R-BTA-2871837",
"R-BT... | [
"REACTOME:R-BTA-110312",
"REACTOME:R-BTA-110314",
"REACTOME:R-BTA-110320",
"REACTOME:R-BTA-1169091",
"REACTOME:R-BTA-1234176",
"REACTOME:R-BTA-1236978",
"REACTOME:R-BTA-174084",
"REACTOME:R-BTA-174154",
"REACTOME:R-BTA-174178",
"REACTOME:R-BTA-174184",
"REACTOME:R-BTA-174411",
"REACTOME:R-BTA-... | 755 | [
"1d2n",
"1do0",
"1do2",
"1e32",
"1e94",
"1f2t",
"1f2u",
"1g3i",
"1g41",
"1g4a",
"1g4b",
"1hqy",
"1ht1",
"1ht2",
"1im2",
"1iqp",
"1ixz",
"1iy0",
"1iy1",
"1iy2",
"1jbk",
"1ksf",
"1kyi",
"1lv7",
"1nsf",
"1ofh",
"1ofi",
"1qvr",
"1r6b",
"1r7r",
"1s3s",
"1sxj"... | 933 | [
"PUB00014779",
"PUB00033933",
"PUB00043605",
"PUB00043606"
] | [
"15037233",
"16919475",
"17201069",
"16828312"
] | [
"Phylogenetic analysis of AAA proteins.",
"Proteasomes and their associated ATPases: a destructive combination.",
"[Structure, function and mechanisms of action of ATPases from the AAA superfamily of proteins]",
"Classification of AAA+ proteins."
] | [
2004,
2006,
2006,
2006
] | 4 | [] | [
"IPR047533",
"IPR047828",
"IPR047858",
"IPR048612"
] | 0 | 4 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
8231,
275976,
292068,
1854,
6548
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
609,
45,
247,
99,
7,
253,
145,
45,
334,
215,
34,
34,
1071
] | 13 | true | Domain | ATPase, AAA-type, core | ATPase, AAA-type, core | ATPase_AAA_core | 3 |
IPR003960 | 3,960 | ATPase, AAA-type, conserved site | ATPase_AAA_CS | Conserved_site | 196,527 | false | false | The functional variety seen between AAA ATPases is in part due to their extensive number of accessory domains and factors, and to their variable organisation within oligomeric assemblies, in addition to changes in key functional residues within the ATPase domain itself. This entry covers a highly conserved region in th... | [
"GO:0005524",
"GO:0016887"
] | [
"ATP binding",
"ATP hydrolysis activity"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PROSITE"
] | [
"PS00674"
] | [
"AAA"
] | [
196527
] | 1 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00572",
"R-BTA-1169091",
"R-BTA-1234176",
"R-BTA-1236978",
"R-BTA-174084",
"R-BTA-174154",
"R-BTA-174178",
"R-BTA-174184",
"R-BTA-187577",
"R-BTA-195253",
"R-BTA-202424",
"R-BTA-2467813",
"R-BTA-2871837",
"R-BTA-349425",
"R-BTA-350562",
"R-BTA-382556",
"R-BTA-450408",
"R-BTA-4... | [
"PROSITEDOC:PDOC00572",
"REACTOME:R-BTA-1169091",
"REACTOME:R-BTA-1234176",
"REACTOME:R-BTA-1236978",
"REACTOME:R-BTA-174084",
"REACTOME:R-BTA-174154",
"REACTOME:R-BTA-174178",
"REACTOME:R-BTA-174184",
"REACTOME:R-BTA-187577",
"REACTOME:R-BTA-195253",
"REACTOME:R-BTA-202424",
"REACTOME:R-BTA-2... | 569 | [
"1e32",
"1ixz",
"1iy0",
"1iy1",
"1iy2",
"1lv7",
"1r7r",
"1s3s",
"1xwi",
"2ce7",
"2cea",
"2dhr",
"2qp9",
"2qpa",
"2r62",
"2r65",
"2rko",
"2x8a",
"2zam",
"2zan",
"2zao",
"3b9p",
"3cf0",
"3cf1",
"3cf2",
"3cf3",
"3d8b",
"3eie",
"3eih",
"3h4m",
"3hu1",
"3hu2"... | 495 | [
"PUB00014779",
"PUB00033933",
"PUB00043605",
"PUB00043606"
] | [
"15037233",
"16919475",
"17201069",
"16828312"
] | [
"Phylogenetic analysis of AAA proteins.",
"Proteasomes and their associated ATPases: a destructive combination.",
"[Structure, function and mechanisms of action of ATPases from the AAA superfamily of proteins]",
"Classification of AAA+ proteins."
] | [
2004,
2006,
2006,
2006
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
4544,
44862,
145899,
131,
1091
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
343,
28,
76,
59,
1,
119,
71,
20,
197,
123,
21,
20,
543
] | 13 | true | Conserved_site | ATPase, AAA-type, conserved site | ATPase, AAA-type, conserved site | ATPase_AAA_CS | 2 |
IPR003963 | 3,963 | Bi-component toxin, staphylococci | Bi-component_toxin_staph | Family | 678 | false | false | Many virulence mechanisms are employed by Staphylococci to induce pathogenesis: these can include polysaccharide capsules and exotoxins [ ]. Examples of the latter are bi-component toxins, which involve the synergistic combination of an "S" and an "F" component. These undergo conformational changes in their protein str... | [
"GO:0005576"
] | [
"extracellular region"
] | [
"cellular_component"
] | 1 | [
"PRINTS",
"NCBIFAM"
] | [
"PR01468",
"TIGR01002"
] | [
"BICOMPNTOXIN",
"hlyII"
] | [
675,
543
] | 2 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-844456",
"R-HSA-9660826"
] | [
"REACTOME:R-HSA-844456",
"REACTOME:R-HSA-9660826"
] | 2 | [
"1lkf",
"1pvl",
"1t5r",
"2lkf",
"2qk7",
"2ygt",
"3anz",
"3b07",
"3lkf",
"3m2l",
"3m3r",
"3m4d",
"3m4e",
"3roh",
"4h56",
"4i0n",
"4idj",
"4iya",
"4iyc",
"4iyt",
"4izl",
"4j0o",
"4p1x",
"4p1y",
"4p24",
"4q7g",
"4tw1",
"4u6v",
"4yhd",
"5k59",
"6rhv",
"6rhw"... | 62 | [
"PUB00008306",
"PUB00067858",
"PUB00067859"
] | [
"9350200",
"12636257",
"8467905"
] | [
"Composition of staphylococcal bi-component toxins determines pathophysiological reactions.",
"Purification, cloning and characterization of variant LukE-LukD with strong leukocidal activity of staphylococcal bi-component leukotoxin family.",
"The two Staphylococcal bi-component toxins, leukocidin and gamma-hem... | [
1997,
2003,
1993
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viruses"
] | [
618,
60
] | 2 | [] | [] | 0 | true | Family | Bi-component toxin, staphylococci | Bi-component toxin, staphylococci | Bi-component_toxin_staph | 9 |
IPR003964 | 3,964 | Carbamate kinase | Carb_kinase | Family | 10,167 | false | false | The arginine dihydrolase (AD) pathway is found in many prokaryotes and some primitive eukaryotes. The three- enzyme anaerobic pathway breaks down L-arginine to form 1 mol of ATP, carbon dioxide and ammonia. In simpler bacteria, the first enzyme, arginine deiminase, can account for up to 10% of total cell protein [ ]. C... | [
"GO:0008804",
"GO:0006525"
] | [
"carbamate kinase activity",
"arginine metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF",
"PANTHER",
"NCBIFAM",
"CDD"
] | [
"PIRSF000723",
"PTHR30409",
"TIGR00746",
"cd04235"
] | [
"Carbamate_kin",
"",
"arcC",
"AAK_CK"
] | [
9377,
10166,
7134,
9400
] | 4 | [
"EC",
"GP",
"GP",
"GP"
] | [
"2.7.2.2",
"GenProp0639",
"GenProp0687",
"GenProp1357"
] | [
"EC:2.7.2.2",
"GP:GenProp0639",
"GP:GenProp0687",
"GP:GenProp1357"
] | 4 | [
"1b7b",
"1e19",
"2e9y",
"2we4",
"2we5",
"3kzf",
"4axs",
"4jz7",
"4jz8",
"4jz9",
"4olc",
"8crv"
] | 12 | [
"PUB00008308",
"PUB00008309",
"PUB00008310",
"PUB00008311"
] | [
"9504342",
"2537202",
"9851988",
"10211841"
] | [
"Anaerobic bacterial metabolism in the ancient eukaryote Giardia duodenalis.",
"Sequence analysis and expression of the arginine-deiminase and carbamate-kinase genes of Pseudomonas aeruginosa.",
"The arcABDC gene cluster, encoding the arginine deiminase pathway of Bacillus licheniformis, and its activation by t... | [
1998,
1989,
1998,
1999
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
262,
9560,
135,
210
] | 4 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Family | Carbamate kinase | Carbamate kinase | Carb_kinase | 7 |
IPR003965 | 3,965 | Fatty acid synthase | Fatty_acid_synthase | Domain | 13,302 | false | false | The yeast fatty acid synthase (FAS) is a hexameric complex (alpha 6 beta 6) of two multifunctional proteins, alpha and beta [ ]. The alpha subunit contains two of the seven enzymatic activities required for the synthesis of fatty acids, together with the site for attachment of the prosthetic group 4'-phosphopantetheine... | [
"GO:0004312",
"GO:0006633",
"GO:0005835"
] | [
"fatty acid synthase activity",
"fatty acid biosynthetic process",
"fatty acid synthase complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01483"
] | [
"FASYNTHASE"
] | [
13302
] | 1 | [
"EC",
"EC",
"EC",
"EC",
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC... | [
"1.3.1.9",
"2.3.1.38",
"2.3.1.39",
"2.3.1.86",
"3.1.2.14",
"4.2.1.59",
"PWY-4381",
"PWY-5142",
"PWY-5147",
"PWY-5366",
"PWY-5367",
"PWY-5966",
"PWY-5971",
"PWY-5973",
"PWY-5989",
"PWY-5994",
"PWY-6113",
"PWY-6282",
"PWY-6519",
"PWY-6799",
"PWY-7388",
"PWY-7663",
"PWY-7664... | [
"EC:1.3.1.9",
"EC:2.3.1.38",
"EC:2.3.1.39",
"EC:2.3.1.86",
"EC:3.1.2.14",
"EC:4.2.1.59",
"METACYC:PWY-4381",
"METACYC:PWY-5142",
"METACYC:PWY-5147",
"METACYC:PWY-5366",
"METACYC:PWY-5367",
"METACYC:PWY-5966",
"METACYC:PWY-5971",
"METACYC:PWY-5973",
"METACYC:PWY-5989",
"METACYC:PWY-5994... | 38 | [
"1iq6",
"2b3m",
"2pff",
"2uv8",
"2vkz",
"3hmj",
"3k67",
"3wew",
"4oob",
"4v58",
"4v59",
"4v8l",
"4v8v",
"4v8w",
"5cpg",
"6gjc",
"6jsh",
"6jsi",
"6ql5",
"6ql6",
"6ql7",
"6ql9",
"6ta1",
"6u5t",
"6u5u",
"6u5v",
"6u5w",
"6wc7",
"7bc4",
"7q5s",
"7tui",
"8prv"... | 51 | [
"PUB00008312",
"PUB00008313",
"PUB00008314"
] | [
"3031066",
"2034224",
"8643646"
] | [
"Complementation of mutations and nucleotide sequence of FAS1 gene encoding beta subunit of yeast fatty acid synthase.",
"The pentafunctional FAS1 genes of Saccharomyces cerevisiae and Yarrowia lipolytica are co-linear and considerably longer than previously estimated.",
"Twenty-five coregulated transcripts def... | [
1987,
1991,
1996
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
57,
9931,
3174,
140
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Domain | Fatty acid synthase | Fatty acid synthase | Fatty_acid_synthase | 5 |
IPR003966 | 3,966 | Prothrombin/thrombin | Prothrombin/thrombin | Family | 1,183 | false | false | Thrombin belongs to the MEROPS peptidase family S1, subfamily S1A. Prothrombin consists of an N-terminal gamma-carboxyglutamate (GLA) domain, two kringle domains, and the S1A peptidase catalytic domain. The cleavage of prothrombin to thrombin is catalysed by the prothrombinase enzyme complex that consists of serine pro... | [
"GO:0004252",
"GO:0005509",
"GO:0006508",
"GO:0007596"
] | [
"serine-type endopeptidase activity",
"calcium ion binding",
"proteolysis",
"blood coagulation"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"biological_process"
] | 4 | [
"PIRSF",
"PRINTS"
] | [
"PIRSF001149",
"PR01505"
] | [
"Thrombin",
"PROTHROMBIN"
] | [
740,
1166
] | 2 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.4.21.5",
"R-HSA-140837",
"R-HSA-140875",
"R-HSA-159740",
"R-HSA-159763",
"R-HSA-159782",
"R-HSA-202733",
"R-HSA-375276",
"R-HSA-381426",
"R-HSA-416476",
"R-HSA-456926",
"R-HSA-76009",
"R-HSA-9657688",
"R-HSA-9672391",
"R-HSA-977606",
"R-MMU-140837",
"R-MMU-140875",
"R-MMU-159740... | [
"EC:3.4.21.5",
"REACTOME:R-HSA-140837",
"REACTOME:R-HSA-140875",
"REACTOME:R-HSA-159740",
"REACTOME:R-HSA-159763",
"REACTOME:R-HSA-159782",
"REACTOME:R-HSA-202733",
"REACTOME:R-HSA-375276",
"REACTOME:R-HSA-381426",
"REACTOME:R-HSA-416476",
"REACTOME:R-HSA-456926",
"REACTOME:R-HSA-76009",
"RE... | 38 | [
"1a0h",
"1a2c",
"1a3b",
"1a3e",
"1a46",
"1a4w",
"1a5g",
"1a61",
"1abi",
"1abj",
"1ad8",
"1ae8",
"1afe",
"1aht",
"1ai8",
"1aix",
"1avg",
"1awf",
"1awh",
"1ay6",
"1b5g",
"1b7x",
"1ba8",
"1bb0",
"1bbr",
"1bcu",
"1bhx",
"1bmm",
"1bmn",
"1bth",
"1c1u",
"1c1v"... | 501 | [
"PUB00008317",
"PUB00008318",
"PUB00008319",
"PUB00017186"
] | [
"2583108",
"10051558",
"1557383",
"9535876"
] | [
"The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment.",
"Unexpected crucial role of residue 225 in serine proteases.",
"Partial characterization of vertebrate prothrombin cDNAs: amplification and... | [
1989,
1999,
1992,
1998
] | 4 | [
"IPR001314"
] | [] | 1 | 0 | 1 | [
"Eumetazoa"
] | [
1183
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
4,
3,
4
] | 4 | true | Family | Prothrombin/thrombin | Prothrombin/thrombin | Prothrombin/thrombin | 3 |
IPR003968 | 3,968 | Potassium channel, voltage dependent, Kv | K_chnl_volt-dep_Kv | Family | 34,298 | false | false | This entry represents the entire Kv family of voltage-dependent potassium channels. The Kv family can be divided into several subfamilies on the basis of sequence similarity and function. Four of these subfamilies, Kv1 (Shaker), Kv2 (Shab), Kv3 (Shaw) and Kv4 (Shal), consist of pore-forming alpha subunits that associat... | [
"GO:0005249",
"GO:0006813",
"GO:0008076"
] | [
"voltage-gated potassium channel activity",
"potassium ion transport",
"voltage-gated potassium channel complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01491"
] | [
"KVCHANNEL"
] | [
34298
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-1296072",
"R-BTA-5576894",
"R-CEL-381676",
"R-CEL-5576890",
"R-DME-1296072",
"R-DME-381676",
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"REACTOME:R-GGA-1296072",
"REACTOME:R-GGA-381676",
"REACTOME:R-HSA-1296072",
"REACTOME:R... | 22 | [
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"3lnm",
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"7phi",
"7phk",
"7phl",
"7pqt",
"7pqu",
"7sip",
"7sit",
"7siz",
"7sj1"... | 65 | [
"PUB00008322",
"PUB00009391"
] | [
"9305895",
"10712896"
] | [
"New modulatory alpha subunits for mammalian Shab K+ channels.",
"Potassium channels: watching a voltage-sensor tilt and twist."
] | [
1997,
2000
] | 2 | [] | [
"IPR003969",
"IPR003970",
"IPR003971",
"IPR003972",
"IPR003973",
"IPR003974",
"IPR003975"
] | 0 | 7 | 0 | [
"Bacteria",
"Eukaryota",
"Stenosarchaea group",
"marine sediment metagenome"
] | [
23,
34270,
4,
1
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
40,
106,
23,
52,
49,
81
] | 6 | true | Family | Potassium channel, voltage dependent, Kv | Potassium channel, voltage dependent, Kv | K_chnl_volt-dep_Kv | 1 |
IPR003969 | 3,969 | Potassium channel, voltage dependent, Kv6 | K_chnl_volt-dep_Kv6 | Family | 1,671 | false | false | Potassium channels are the most diverse group of the ion channel family [ , ]. They are important in shaping the action potential, and in neuronal excitability and plasticity [ ]. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups [ ]: the pr... | [
"GO:0005249",
"GO:0006813",
"GO:0008076"
] | [
"voltage-gated potassium channel activity",
"potassium ion transport",
"voltage-gated potassium channel complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01492"
] | [
"KV6CHANNEL"
] | [
1671
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-GGA-1296072",
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"REACTOME:R-HSA-381676",
"REACTOME:R-MMU-1296072",
"REACTOME:R-RNO-1296072",
"REACTOME:R-RNO-381676"
] | 7 | [] | 0 | [
"PUB00001055",
"PUB00001622",
"PUB00002771",
"PUB00004011",
"PUB00004020",
"PUB00006577",
"PUB00008322",
"PUB00008323",
"PUB00009378",
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"The molecular biology of K+ channels.",
"Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.",
"Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.",
"Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso... | [
1991,
1991,
1992,
1988,
1988,
1989,
1997,
1998,
2000,
2000
] | 10 | [
"IPR003968"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
1671
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
5,
4,
5
] | 4 | true | Family | Potassium channel, voltage dependent, Kv6 | Potassium channel, voltage dependent, Kv6 | K_chnl_volt-dep_Kv6 | 8 |
IPR003970 | 3,970 | Potassium channel, voltage dependent, Kv8.1 | K_chnl_volt-dep_Kv8.1 | Family | 586 | false | false | Potassium channels are the most diverse group of the ion channel family [ , ]. They are important in shaping the action potential, and in neuronal excitability and plasticity [ ]. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups [ ]: the pr... | [
"GO:0005249",
"GO:0006813",
"GO:0008076"
] | [
"voltage-gated potassium channel activity",
"potassium ion transport",
"voltage-gated potassium channel complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01493"
] | [
"KV8CHANNEL"
] | [
586
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1296072",
"R-MMU-1296072",
"R-RNO-1296072"
] | [
"REACTOME:R-HSA-1296072",
"REACTOME:R-MMU-1296072",
"REACTOME:R-RNO-1296072"
] | 3 | [] | 0 | [
"PUB00001055",
"PUB00001622",
"PUB00002771",
"PUB00004011",
"PUB00004020",
"PUB00006577",
"PUB00008322",
"PUB00008908",
"PUB00009378",
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"The molecular biology of K+ channels.",
"Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.",
"Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.",
"Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso... | [
1991,
1991,
1992,
1988,
1988,
1989,
1997,
1997,
2000,
2000
] | 10 | [
"IPR003968"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
586
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
1,
3
] | 3 | true | Family | Potassium channel, voltage dependent, Kv8.1 | Potassium channel, voltage dependent, Kv8.1 | K_chnl_volt-dep_Kv8.1 | 7 |
IPR003971 | 3,971 | Potassium channel, voltage dependent, Kv5/Kv9 | K_chnl_volt-dep_Kv5/Kv9 | Family | 8,914 | false | false | The Kv family can be divided into several subfamilies on the basis of sequence similarity and function. Four of these subfamilies, Kv1 (Shaker), Kv2 (Shab), Kv3 (Shaw) and Kv4 (Shal), consist of pore-forming alpha subunits that associate with different types of beta subunit. Each alpha subunit comprises six hydrophobic... | [
"GO:0005249",
"GO:0006813",
"GO:0008076"
] | [
"voltage-gated potassium channel activity",
"potassium ion transport",
"voltage-gated potassium channel complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01494"
] | [
"KV9CHANNEL"
] | [
8914
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-381676",
"R-DME-1296072",
"R-DME-381676",
"R-HSA-1296072",
"R-HSA-381676",
"R-MMU-1296072",
"R-MMU-381676",
"R-RNO-1296072",
"R-RNO-381676"
] | [
"REACTOME:R-CEL-381676",
"REACTOME:R-DME-1296072",
"REACTOME:R-DME-381676",
"REACTOME:R-HSA-1296072",
"REACTOME:R-HSA-381676",
"REACTOME:R-MMU-1296072",
"REACTOME:R-MMU-381676",
"REACTOME:R-RNO-1296072",
"REACTOME:R-RNO-381676"
] | 9 | [
"7re5",
"7spd"
] | 2 | [
"PUB00001055",
"PUB00001622",
"PUB00002771",
"PUB00004011",
"PUB00004020",
"PUB00006577",
"PUB00008322",
"PUB00008911",
"PUB00009378",
"PUB00009391"
] | [
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"1373731",
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"2555158",
"9305895",
"10484328",
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] | [
"The molecular biology of K+ channels.",
"Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.",
"Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.",
"Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso... | [
1991,
1991,
1992,
1988,
1988,
1989,
1997,
1999,
2000,
2000
] | 10 | [
"IPR003968"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
8914
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
26,
16,
9,
13,
12,
16
] | 6 | true | Family | Potassium channel, voltage dependent, Kv5/Kv9 | Potassium channel, voltage dependent, Kv5/Kv9 | K_chnl_volt-dep_Kv5/Kv9 | 2 |
IPR003972 | 3,972 | Potassium channel, voltage dependent, Kv1 | K_chnl_volt-dep_Kv1 | Family | 9,820 | false | false | Potassium channels are the most diverse group of the ion channel family [ , ]. They are important in shaping the action potential, and in neuronal excitability and plasticity [ ]. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups [ ]: the pr... | [
"GO:0005249",
"GO:0006813",
"GO:0008076"
] | [
"voltage-gated potassium channel activity",
"potassium ion transport",
"voltage-gated potassium channel complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01496"
] | [
"SHAKERCHANEL"
] | [
9820
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
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"R-MMU-1296072",
"R-MMU-5576890",
"R-RNO-1296072",
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"REACTOME:R-HSA-1296072",
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"REACTOME:R-MMU-1296072",
"REACTOME:R-MMU-5576890",
"REACTOME:R-RNO-1296072",
"REACTOME:R-RNO-5576890"
] | 9 | [
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"7siz",
"7sj1",
"7wf3",
"7wf4",
"8teo",
"8vc3",
"8vc4"... | 39 | [
"PUB00001055",
"PUB00001622",
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"PUB00006577",
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"The molecular biology of K+ channels.",
"Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.",
"Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.",
"Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso... | [
1991,
1991,
1992,
1988,
1988,
1989,
2000,
1997,
2000,
2000,
2000
] | 11 | [
"IPR003968"
] | [
"IPR004048",
"IPR004049",
"IPR004050",
"IPR004052",
"IPR004053",
"IPR020467"
] | 1 | 6 | 0 | [
"Candidatus Epulonipiscium fishelsonii",
"Eukaryota"
] | [
1,
9819
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
18,
9,
12,
11,
20
] | 5 | true | Family | Potassium channel, voltage dependent, Kv1 | Potassium channel, voltage dependent, Kv1 | K_chnl_volt-dep_Kv1 | 2 |
IPR003973 | 3,973 | Potassium channel, voltage dependent, Kv2 | K_chnl_volt-dep_Kv2 | Family | 2,202 | false | false | Potassium channels are the most diverse group of the ion channel family [ , ]. They are important in shaping the action potential, and in neuronal excitability and plasticity [ ]. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups [ ]: the pr... | [
"GO:0005249",
"GO:0006813",
"GO:0008076"
] | [
"voltage-gated potassium channel activity",
"potassium ion transport",
"voltage-gated potassium channel complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PRINTS"
] | [
"PF03521",
"PR01495"
] | [
"Kv2channel",
"SHABCHANNEL"
] | [
1798,
1952
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-1296072",
"R-HSA-1296072",
"R-HSA-381676",
"R-MMU-1296072",
"R-MMU-381676",
"R-RNO-1296072",
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"REACTOME:R-MMU-381676",
"REACTOME:R-RNO-1296072",
"REACTOME:R-RNO-381676"
] | 7 | [
"8sd3",
"8sda",
"9o10",
"9o11",
"9o12",
"9o13"
] | 6 | [
"PUB00001055",
"PUB00001622",
"PUB00002771",
"PUB00004011",
"PUB00004020",
"PUB00006577",
"PUB00008322",
"PUB00009378",
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] | [
"The molecular biology of K+ channels.",
"Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.",
"Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.",
"Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso... | [
1991,
1991,
1992,
1988,
1988,
1989,
1997,
2000,
2000,
2005
] | 10 | [
"IPR003968"
] | [
"IPR004350",
"IPR005826"
] | 1 | 2 | 0 | [
"Bilateria"
] | [
2202
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
1,
3,
4,
6
] | 5 | true | Family | Potassium channel, voltage dependent, Kv2 | Potassium channel, voltage dependent, Kv2 | K_chnl_volt-dep_Kv2 | 5 |
IPR003974 | 3,974 | Potassium channel, voltage dependent, Kv3 | K_chnl_volt-dep_Kv3 | Family | 7,636 | false | false | A voltage-dependent potassium channel gene designated Shaw was initially isolated from Drosophila melanogaster (Fruit fly). Subsequently, several vetebrate potassium channels with similar amino acid sequences were found and, together with the D. melanogaster channel, now constitute the Kv3 family. These channels are th... | [
"GO:0005249",
"GO:0006813",
"GO:0008076"
] | [
"voltage-gated potassium channel activity",
"potassium ion transport",
"voltage-gated potassium channel complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01498"
] | [
"SHAWCHANNEL"
] | [
7636
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-1296072",
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"R-HSA-381676",
"R-MMU-1296072",
"R-MMU-381676",
"R-RNO-1296072",
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"REACTOME:R-DME-381676",
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"REACTOME:R-HSA-381676",
"REACTOME:R-MMU-1296072",
"REACTOME:R-MMU-381676",
"REACTOME:R-RNO-1296072",
"REACTOME:R-RNO-381676"
] | 8 | [
"1nn7",
"1s1g",
"2i2r",
"2nz0",
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"7phh",
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"7phk",
"7phl",
"7pqt",
"7pqu",
"8f1c",
"8f1d",
"8quc",
"8qud"
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"PUB00001055",
"PUB00001622",
"PUB00002771",
"PUB00004011",
"PUB00004020",
"PUB00006577",
"PUB00008322",
"PUB00009378",
"PUB00009391"
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"The molecular biology of K+ channels.",
"Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.",
"Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.",
"Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso... | [
1991,
1991,
1992,
1988,
1988,
1989,
1997,
2000,
2000
] | 9 | [
"IPR003968"
] | [
"IPR005403",
"IPR005404",
"IPR005405"
] | 1 | 3 | 0 | [
"Eukaryota"
] | [
7636
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
12,
53,
7,
10,
13,
22
] | 6 | true | Family | Potassium channel, voltage dependent, Kv3 | Potassium channel, voltage dependent, Kv3 | K_chnl_volt-dep_Kv3 | 3 |
IPR003975 | 3,975 | Potassium channel, voltage dependent, Kv4 | K_chnl_volt-dep_Kv4 | Family | 4,127 | false | false | The Kv family can be divided into several subfamilies on the basis of sequence similarity and function. Four of these subfamilies, Kv1 (Shaker), Kv2 (Shab), Kv3 (Shaw) and Kv4 (Shal), consist of pore-forming alpha subunits that associate with different types of beta subunit. Each alpha subunit comprises six hydrophobic... | [
"GO:0005249",
"GO:0006813",
"GO:0008076"
] | [
"voltage-gated potassium channel activity",
"potassium ion transport",
"voltage-gated potassium channel complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01497"
] | [
"SHALCHANNEL"
] | [
4127
] | 1 | [
"REACTOME",
"REACTOME",
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"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
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"R-RNO-1296072",
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"REACTOME:R-MMU-5576894",
"REACTOME:R-RNO-1296072",
"REACTOME:R-RNO-5576894"
] | 10 | [
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"7e84",
"7e87",
"7e8b",
"7e8e",
"7e8h",
"7f0j",
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"7uke",
"7ukf",
"7ukg",
"7ukh",
"7w3y",
"7w6n",
"7w6s",
"7w6t"
] | 20 | [
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"PUB00004020",
"PUB00006577",
"PUB00008322",
"PUB00009378",
"PUB00009391",
"PUB00036046"
] | [
"1772658",
"1879548",
"1373731",
"2448635",
"2451788",
"2555158",
"9305895",
"11178249",
"10712896",
"15269337"
] | [
"The molecular biology of K+ channels.",
"Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.",
"Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.",
"Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso... | [
1991,
1991,
1992,
1988,
1988,
1989,
1997,
2000,
2000,
2004
] | 10 | [
"IPR003968"
] | [
"IPR004054",
"IPR004055",
"IPR004056"
] | 1 | 3 | 0 | [
"Eumetazoa"
] | [
4127
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
9,
2,
8,
6,
9
] | 6 | true | Family | Potassium channel, voltage dependent, Kv4 | Potassium channel, voltage dependent, Kv4 | K_chnl_volt-dep_Kv4 | 8 |
IPR003976 | 3,976 | Two pore domain potassium channel, TREK | 2pore_dom_K_chnl_TREK | Family | 3,304 | false | false | Potassium channels are the most diverse group of the ion channel family [ , ]. They are important in shaping the action potential, and in neuronal excitability and plasticity [ ]. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups [ ]: the pr... | [
"GO:0005267",
"GO:0071805",
"GO:0016020"
] | [
"potassium channel activity",
"potassium ion transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01499"
] | [
"TREKCHANNEL"
] | [
3304
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1299503",
"R-HSA-5576886",
"R-MMU-1299503",
"R-MMU-5576886",
"R-RNO-1299503",
"R-RNO-5576886"
] | [
"REACTOME:R-HSA-1299503",
"REACTOME:R-HSA-5576886",
"REACTOME:R-MMU-1299503",
"REACTOME:R-MMU-5576886",
"REACTOME:R-RNO-1299503",
"REACTOME:R-RNO-5576886"
] | 6 | [
"4bw5",
"4twk",
"4xdj",
"4xdk",
"4xdl",
"6cq6",
"6cq8",
"6cq9",
"6v36",
"6v37",
"6v3c",
"6v3i",
"6w7b",
"6w7c",
"6w7d",
"6w7e",
"6w82",
"6w83",
"6w84",
"6w85",
"6w86",
"6w87",
"6w88",
"6w8a",
"6w8c",
"6w8f",
"8de7",
"8de8",
"8de9",
"8qz1",
"8qz2",
"8qz3"... | 38 | [
"PUB00001055",
"PUB00001278",
"PUB00001298",
"PUB00001308",
"PUB00001622",
"PUB00002771",
"PUB00004011",
"PUB00004020",
"PUB00004219",
"PUB00004878",
"PUB00006577",
"PUB00008327",
"PUB00008328",
"PUB00009378"
] | [
"1772658",
"8605869",
"9003761",
"9312005",
"1879548",
"1373731",
"2448635",
"2451788",
"7651518",
"8917578",
"2555158",
"10835347",
"10747911",
"11178249"
] | [
"The molecular biology of K+ channels.",
"TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure.",
"Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel.",
"TASK, a human background K+ channel to sense external pH variatio... | [
1991,
1996,
1996,
1997,
1991,
1992,
1988,
1988,
1995,
1996,
1989,
2000,
2000,
2000
] | 14 | [
"IPR003280"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
3304
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
23,
12,
9,
10
] | 4 | true | Family | Two pore domain potassium channel, TREK | Two pore domain potassium channel, TREK | 2pore_dom_K_chnl_TREK | 6 |
IPR003977 | 3,977 | E3 ubiquitin-protein ligase parkin | Parkin | Family | 1,855 | false | false | E3 ubiquitin-protein ligase parkin, also called Parkinson juvenile disease protein 2, is an RBR-type E3 ubiquitin-protein ligase that is associated with recessive early onset Parkinson's disease (PD), and exerts a protective effect against dopamine-induced alpha-synuclein-dependent cell toxicity. Mutations in the parki... | [
"GO:0004842",
"GO:0005739",
"GO:0005829"
] | [
"ubiquitin-protein transferase activity",
"mitochondrion",
"cytosol"
] | [
"molecular_function",
"cellular_component",
"cellular_component"
] | 3 | [
"PIRSF",
"PRINTS"
] | [
"PIRSF037880",
"PR01475"
] | [
"Parkin",
"PARKIN"
] | [
1069,
1840
] | 2 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.3.2.31",
"R-DME-5205685",
"R-DME-5689877",
"R-DME-9646399",
"R-DME-983168",
"R-HSA-5205685",
"R-HSA-5675482",
"R-HSA-5689877",
"R-HSA-9646399",
"R-HSA-977225",
"R-HSA-983168",
"R-MMU-5205685",
"R-MMU-5675482",
"R-MMU-5689877",
"R-MMU-9646399",
"R-MMU-983168",
"R-RNO-5205685",
"R... | [
"EC:2.3.2.31",
"REACTOME:R-DME-5205685",
"REACTOME:R-DME-5689877",
"REACTOME:R-DME-9646399",
"REACTOME:R-DME-983168",
"REACTOME:R-HSA-5205685",
"REACTOME:R-HSA-5675482",
"REACTOME:R-HSA-5689877",
"REACTOME:R-HSA-9646399",
"REACTOME:R-HSA-977225",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-520568... | 21 | [
"2m48",
"4bm9",
"4i1f",
"4i1h",
"4k7d",
"4k95",
"4zyn",
"5c1z",
"5c23",
"5c9v",
"5caw",
"5n2w",
"5n38",
"6djw",
"6djx",
"6glc",
"6hue",
"6n13",
"7us1",
"8ik6",
"8ikm",
"8ikt",
"8ikv",
"8jwv",
"8w31",
"8wzn",
"8wzo"
] | 27 | [
"PUB00008328",
"PUB00008917",
"PUB00067022",
"PUB00074717",
"PUB00102793",
"PUB00103490",
"PUB00103491",
"PUB00103493",
"PUB00103495",
"PUB00103496",
"PUB00103497",
"PUB00103498",
"PUB00103499",
"PUB00103500"
] | [
"10747911",
"11078524",
"23661642",
"21532592",
"25621951",
"17846173",
"26254304",
"26254305",
"15823698",
"24741456",
"24751536",
"26161729",
"10973942",
"19801972"
] | [
"TREK-2, a new member of the mechanosensitive tandem-pore K+ channel family.",
"Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1.",
"Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation.",
"UBCH7 r... | [
2000,
2000,
2013,
2011,
2015,
2007,
2015,
2015,
2005,
2014,
2014,
2015,
2000,
2009
] | 14 | [
"IPR031127"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
1855
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
2,
1,
12,
6,
27
] | 6 | true | Family | E3 ubiquitin-protein ligase parkin | E3 ubiquitin-protein ligase parkin | Parkin | 7 |
IPR003978 | 3,978 | Thrombopoietin | Thrombopoietin | Family | 1,024 | false | false | Megakaryocytes are large cells found in the bone marrow that, upon maturation, fragment into platelets. The term thrombopoietin (TPO) was coined in 1958 to describe a possible humoral entity that stimulates megakaryocyte development into platelets. The discovery of a novel haemopoietic cytokine receptor encoded by the ... | [
"GO:0005125",
"GO:0008283",
"GO:0005576"
] | [
"cytokine activity",
"cell population proliferation",
"extracellular region"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS",
"PANTHER"
] | [
"PR01485",
"PTHR10560"
] | [
"THROMBOPTN",
""
] | [
742,
1020
] | 2 | [
"REACTOME"
] | [
"R-HSA-76009"
] | [
"REACTOME:R-HSA-76009"
] | 1 | [
"1v7m",
"1v7n",
"8g04",
"8u18",
"8vu5"
] | 5 | [
"PUB00008331",
"PUB00008332",
"PUB00008333",
"PUB00008334"
] | [
"10377897",
"8202158",
"10582337",
"9417073"
] | [
"The enigmatic megakaryocyte gradually reveals its secrets.",
"Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo.",
"Thrombopoietin and the c-Mpl receptor: insights from gene targeting.",
"Identification of functionally important residues of human thrombopoiet... | [
1999,
1994,
1999,
1998
] | 4 | [
"IPR001323"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
1024
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
5,
4,
5
] | 4 | true | Family | Thrombopoietin | Thrombopoietin | Thrombopoietin | 7 |
IPR003979 | 3,979 | Tropoelastin | Tropoelastin | Family | 1,447 | false | false | Tropoelastin is the precursor to the elastin molecule. Elastin aggregates are responsible for the stretch properties of skin, arterial walls and ligaments, and elastin is implicated in several hereditary diseases, including cutis laxa (where the elasticity of the skin is lost) and elastoderma (similar to cutis laxa but... | [
"GO:0005201",
"GO:0031012"
] | [
"extracellular matrix structural constituent",
"extracellular matrix"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PANTHER"
] | [
"PTHR24018"
] | [
""
] | [
1447
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1474228",
"R-HSA-1566948",
"R-HSA-2129379",
"R-MMU-1474228",
"R-MMU-1566948",
"R-MMU-2129379",
"R-RNO-1474228",
"R-RNO-1566948",
"R-RNO-2129379"
] | [
"REACTOME:R-HSA-1474228",
"REACTOME:R-HSA-1566948",
"REACTOME:R-HSA-2129379",
"REACTOME:R-MMU-1474228",
"REACTOME:R-MMU-1566948",
"REACTOME:R-MMU-2129379",
"REACTOME:R-RNO-1474228",
"REACTOME:R-RNO-1566948",
"REACTOME:R-RNO-2129379"
] | 9 | [] | 0 | [
"PUB00008335",
"PUB00008336",
"PUB00008921",
"PUB00008922"
] | [
"10216959",
"5684878",
"2272748",
"3345315"
] | [
"Elastin: molecular description and function.",
"Evidence for order in the structure of alpha-elastin.",
"Conformation of a cyclic decapeptide analog of a repeat pentapeptide sequence of elastin: cyclo-bis(valyl-prolyl-alanyl-valyl-glycyl).",
"Chemotaxis of fibroblasts toward nonapeptide of elastin."
] | [
1999,
1968,
1990,
1988
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1447
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
18,
3,
13
] | 4 | true | Family | Tropoelastin | Tropoelastin | Tropoelastin | 2 |
IPR003980 | 3,980 | Histamine H3 receptor | Histamine_H3_rcpt | Family | 2,557 | false | false | This entry represents the histamine H3 receptor (also known as HH3R), which functions as presynaptic autoreceptor on histamine-containing neurones. The H3 receptor is expressed abundantly in the CNS, with highest levels found in the thalamus, caudate nucleus, cortex [ , ], hypothalamus, hippocampus and olfactory tuberc... | [
"GO:0004969",
"GO:0007186",
"GO:0016020"
] | [
"histamine receptor activity",
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01471"
] | [
"HISTAMINEH3R"
] | [
2557
] | 1 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"264",
"R-HSA-390650",
"R-MMU-390650",
"R-RNO-390650"
] | [
"IUPHAR:264",
"REACTOME:R-HSA-390650",
"REACTOME:R-MMU-390650",
"REACTOME:R-RNO-390650"
] | 4 | [
"7f61",
"8yn5",
"8yn6",
"8yn7",
"8yn8",
"8yuu",
"8yuv",
"9jeq"
] | 8 | [
"PUB00008338",
"PUB00010558",
"PUB00063488",
"PUB00063489",
"PUB00063490",
"PUB00063491",
"PUB00063500",
"PUB00063501",
"PUB00063502",
"PUB00063503",
"PUB00063504",
"PUB00063506",
"PUB00063507",
"PUB00063549",
"PUB00063550",
"PUB00063551",
"PUB00063555"
] | [
"10347254",
"11179434",
"6188956",
"3033516",
"8169830",
"8838460",
"16402096",
"19772756",
"12113221",
"17490952",
"19843401",
"9311023",
"12626656",
"9652190",
"11130725",
"1846044",
"15665857"
] | [
"Cloning and functional expression of the human histamine H3 receptor.",
"Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow.",
"Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor.",
"Highly potent and select... | [
1999,
2001,
1983,
1987,
1994,
1996,
2006,
2009,
2002,
2007,
2009,
1997,
2003,
1998,
2000,
1991,
2005
] | 17 | [
"IPR000276"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Methanocorpusculum vombati"
] | [
19,
2537,
1
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
12,
12,
9
] | 4 | true | Family | Histamine H3 receptor | Histamine H3 receptor | Histamine_H3_rcpt | 3 |
IPR003981 | 3,981 | Leukotriene B4 receptor | Leukotriene_B4_rcpt | Family | 1,157 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0004974",
"GO:0007186",
"GO:0016020"
] | [
"leukotriene receptor activity",
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01476"
] | [
"LTBRECEPTOR"
] | [
1157
] | 1 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"267",
"R-BTA-391906",
"R-BTA-416476",
"R-HSA-391906",
"R-HSA-416476",
"R-MMU-391906",
"R-MMU-416476",
"R-RNO-391906",
"R-RNO-416476"
] | [
"IUPHAR:267",
"REACTOME:R-BTA-391906",
"REACTOME:R-BTA-416476",
"REACTOME:R-HSA-391906",
"REACTOME:R-HSA-416476",
"REACTOME:R-MMU-391906",
"REACTOME:R-MMU-416476",
"REACTOME:R-RNO-391906",
"REACTOME:R-RNO-416476"
] | 9 | [
"7k15",
"7vkt"
] | 2 | [
"PUB00000131",
"PUB00002477",
"PUB00004960",
"PUB00004961",
"PUB00008340",
"PUB00008928",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816"
] | [
"2111655",
"2830256",
"8386361",
"8170923",
"11006272",
"10943331",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293"
] | [
"G proteins in signal transduction.",
"G protein involvement in receptor-effector coupling.",
"Design of a discriminating fingerprint for G-protein-coupled receptors.",
"Fingerprinting G-protein-coupled receptors.",
"A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization."... | [
1990,
1988,
1993,
1994,
2000,
2000,
2003,
1994,
2005,
2009,
2006,
2013
] | 12 | [
"IPR000276"
] | [
"IPR003982",
"IPR003983"
] | 1 | 2 | 0 | [
"Gnathostomata"
] | [
1157
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
9,
4,
4
] | 4 | true | Family | Leukotriene B4 receptor | Leukotriene B4 receptor | Leukotriene_B4_rcpt | 7 |
IPR003982 | 3,982 | Leukotriene B4 type 2 receptor | Leukotriene_B4_typ-2_rcpt | Family | 182 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0004974",
"GO:0007186",
"GO:0016020"
] | [
"leukotriene receptor activity",
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01478"
] | [
"LTB2RECEPTOR"
] | [
182
] | 1 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"268",
"R-HSA-391906",
"R-HSA-416476",
"R-MMU-391906",
"R-MMU-416476",
"R-RNO-391906",
"R-RNO-416476"
] | [
"IUPHAR:268",
"REACTOME:R-HSA-391906",
"REACTOME:R-HSA-416476",
"REACTOME:R-MMU-391906",
"REACTOME:R-MMU-416476",
"REACTOME:R-RNO-391906",
"REACTOME:R-RNO-416476"
] | 7 | [] | 0 | [
"PUB00000131",
"PUB00002477",
"PUB00004960",
"PUB00004961",
"PUB00008340",
"PUB00008928",
"PUB00008933",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816"
] | [
"2111655",
"2830256",
"8386361",
"8170923",
"11006272",
"10943331",
"10889186",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293"
] | [
"G proteins in signal transduction.",
"G protein involvement in receptor-effector coupling.",
"Design of a discriminating fingerprint for G-protein-coupled receptors.",
"Fingerprinting G-protein-coupled receptors.",
"A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization."... | [
1990,
1988,
1993,
1994,
2000,
2000,
2000,
2003,
1994,
2005,
2009,
2006,
2013
] | 13 | [
"IPR003981"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota"
] | [
3,
179
] | 2 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
1,
2
] | 3 | true | Family | Leukotriene B4 type 2 receptor | Leukotriene B4 type 2 receptor | Leukotriene_B4_typ-2_rcpt | 1 |
IPR003983 | 3,983 | Leukotriene B4 type 1 receptor | Leukotriene_B4_typ-1_rcpt | Family | 209 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0004974",
"GO:0007186",
"GO:0016020"
] | [
"leukotriene receptor activity",
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01477"
] | [
"LTB1RECEPTOR"
] | [
209
] | 1 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"267",
"R-BTA-391906",
"R-BTA-416476",
"R-HSA-391906",
"R-HSA-416476",
"R-MMU-391906",
"R-MMU-416476",
"R-RNO-391906",
"R-RNO-416476"
] | [
"IUPHAR:267",
"REACTOME:R-BTA-391906",
"REACTOME:R-BTA-416476",
"REACTOME:R-HSA-391906",
"REACTOME:R-HSA-416476",
"REACTOME:R-MMU-391906",
"REACTOME:R-MMU-416476",
"REACTOME:R-RNO-391906",
"REACTOME:R-RNO-416476"
] | 9 | [
"7k15",
"7vkt"
] | 2 | [
"PUB00000131",
"PUB00002477",
"PUB00004960",
"PUB00004961",
"PUB00008340",
"PUB00008928",
"PUB00008940",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816"
] | [
"2111655",
"2830256",
"8386361",
"8170923",
"11006272",
"10943331",
"10673227",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293"
] | [
"G proteins in signal transduction.",
"G protein involvement in receptor-effector coupling.",
"Design of a discriminating fingerprint for G-protein-coupled receptors.",
"Fingerprinting G-protein-coupled receptors.",
"A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization."... | [
1990,
1988,
1993,
1994,
2000,
2000,
2000,
2003,
1994,
2005,
2009,
2006,
2013
] | 13 | [
"IPR003981"
] | [] | 1 | 0 | 1 | [
"Opisthokonta"
] | [
209
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
2
] | 3 | true | Family | Leukotriene B4 type 1 receptor | Leukotriene B4 type 1 receptor | Leukotriene_B4_typ-1_rcpt | 7 |
IPR003984 | 3,984 | Neurotensin receptor | NT_rcpt | Family | 992 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0016492",
"GO:0007186",
"GO:0016020"
] | [
"G protein-coupled neurotensin receptor activity",
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01479"
] | [
"NEUROTENSINR"
] | [
992
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-375276",
"R-HSA-416476",
"R-MMU-375276",
"R-MMU-416476",
"R-RNO-375276",
"R-RNO-416476"
] | [
"REACTOME:R-HSA-375276",
"REACTOME:R-HSA-416476",
"REACTOME:R-MMU-375276",
"REACTOME:R-MMU-416476",
"REACTOME:R-RNO-375276",
"REACTOME:R-RNO-416476"
] | 6 | [
"3zev",
"4buo",
"4bv0",
"4bwb",
"6os9",
"6osa",
"6pwc",
"6up7",
"6yvr",
"6z4q",
"6z4s",
"6z4v",
"6z66",
"6z8n",
"6za8",
"6zin",
"7l0p",
"7l0q",
"7l0r",
"7l0s",
"7ul2",
"8fmz",
"8fn0",
"8fn1",
"8jpb",
"8jpc",
"8jpf",
"8zyt",
"8zyu",
"8zyy",
"9m0d"
] | 31 | [
"PUB00000131",
"PUB00002477",
"PUB00004960",
"PUB00004961",
"PUB00007633",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816"
] | [
"2111655",
"2830256",
"8386361",
"8170923",
"10390649",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293"
] | [
"G proteins in signal transduction.",
"G protein involvement in receptor-effector coupling.",
"Design of a discriminating fingerprint for G-protein-coupled receptors.",
"Fingerprinting G-protein-coupled receptors.",
"Neurotensin and neurotensin receptors.",
"The G protein-coupled receptor repertoires of h... | [
1990,
1988,
1993,
1994,
1999,
2003,
1994,
2005,
2009,
2006,
2013
] | 11 | [
"IPR000276"
] | [
"IPR003985",
"IPR003986"
] | 1 | 2 | 0 | [
"Vertebrata"
] | [
992
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
10,
2,
7,
6
] | 4 | true | Family | Neurotensin receptor | Neurotensin receptor | NT_rcpt | 9 |
IPR003986 | 3,986 | Neurotensin type 2 receptor | NT2_rcpt | Family | 170 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0016492",
"GO:0007186",
"GO:0016020"
] | [
"G protein-coupled neurotensin receptor activity",
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01481"
] | [
"NEUROTENSN2R"
] | [
170
] | 1 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"310",
"R-HSA-375276",
"R-HSA-416476",
"R-MMU-375276",
"R-MMU-416476",
"R-RNO-375276",
"R-RNO-416476"
] | [
"IUPHAR:310",
"REACTOME:R-HSA-375276",
"REACTOME:R-HSA-416476",
"REACTOME:R-MMU-375276",
"REACTOME:R-MMU-416476",
"REACTOME:R-RNO-375276",
"REACTOME:R-RNO-416476"
] | 7 | [] | 0 | [
"PUB00000131",
"PUB00002477",
"PUB00004960",
"PUB00004961",
"PUB00007633",
"PUB00007635",
"PUB00007636",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816"
] | [
"2111655",
"2830256",
"8386361",
"8170923",
"10390649",
"9851594",
"9627096",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293"
] | [
"G proteins in signal transduction.",
"G protein involvement in receptor-effector coupling.",
"Design of a discriminating fingerprint for G-protein-coupled receptors.",
"Fingerprinting G-protein-coupled receptors.",
"Neurotensin and neurotensin receptors.",
"Neurotensin is an antagonist of the human neuro... | [
1990,
1988,
1993,
1994,
1999,
1998,
1998,
2003,
1994,
2005,
2009,
2006,
2013
] | 13 | [
"IPR003984"
] | [] | 1 | 0 | 1 | [
"Sarcopterygii"
] | [
170
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
6,
4
] | 3 | true | Family | Neurotensin type 2 receptor | Neurotensin type 2 receptor | NT2_rcpt | 8 |
IPR003987 | 3,987 | Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal | ICAM_VCAM_N | Domain | 3,612 | false | false | Intercellular adhesion molecules (ICAMs) and vascular cell adhesion molecule-1 (VCAM-1) are part of the immunoglobulin superfamily. They are important in inflammation, immune responses and in intracellular signalling events [ ]. The ICAM family consists of five members, designated ICAM-1 to ICAM-5. They are known to bi... | [
"GO:0098609",
"GO:0016020"
] | [
"cell-cell adhesion",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01472"
] | [
"ICAMVCAM1"
] | [
3612
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CFA-198933",
"R-CFA-216083",
"R-HSA-198933",
"R-HSA-216083",
"R-HSA-5621575",
"R-HSA-6783783",
"R-HSA-6785807",
"R-HSA-877300",
"R-MMU-198933",
"R-MMU-216083",
"R-MMU-5621575",
"R-RNO-198933",
"R-RNO-216083"
] | [
"REACTOME:R-CFA-198933",
"REACTOME:R-CFA-216083",
"REACTOME:R-HSA-198933",
"REACTOME:R-HSA-216083",
"REACTOME:R-HSA-5621575",
"REACTOME:R-HSA-6783783",
"REACTOME:R-HSA-6785807",
"REACTOME:R-HSA-877300",
"REACTOME:R-MMU-198933",
"REACTOME:R-MMU-216083",
"REACTOME:R-MMU-5621575",
"REACTOME:R-RNO... | 13 | [
"1d3e",
"1d3i",
"1d3l",
"1iam",
"1ic1",
"1ij9",
"1mq8",
"1vca",
"1vsc",
"1z7z",
"1zxq",
"3bn3",
"4oi9",
"4oia",
"4oib",
"5mza",
"6s8u",
"7bg7"
] | 18 | [
"PUB00007637",
"PUB00007638",
"PUB00007639",
"PUB00007640",
"PUB00007641",
"PUB00007642",
"PUB00009398",
"PUB00009399",
"PUB00009400"
] | [
"10352278",
"10725740",
"10846180",
"10741396",
"11133225",
"7531291",
"9151947",
"10998349",
"9539703"
] | [
"ICAM-2 and a peptide from its binding domain are efficient activators of leukocyte adhesion and integrin affinity.",
"Shear and time-dependent changes in Mac-1, LFA-1, and ICAM-3 binding regulate neutrophil homotypic adhesion.",
"Binding sites of leukocyte beta 2 integrins (LFA-1, Mac-1) on the human ICAM-4/LW... | [
1999,
2000,
2000,
2000,
2001,
1995,
1997,
2000,
1998
] | 9 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
3612
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
13,
30,
29,
25
] | 4 | true | Domain | Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal | Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal | ICAM_VCAM_N | 9 |
IPR003988 | 3,988 | Intercellular adhesion molecule | ICAM | Domain | 760 | false | false | Intercellular adhesion molecules (ICAMs) and vascular cell adhesion molecule-1 (VCAM-1) are part of the immunoglobulin superfamily. They are important in inflammation, immune responses and in intracellular signalling events [ ]. The ICAM family consists of five members, designated ICAM-1 to ICAM-5. They are known to bi... | [
"GO:0098609",
"GO:0016020"
] | [
"cell-cell adhesion",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01473"
] | [
"ICAM"
] | [
760
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CFA-198933",
"R-CFA-216083",
"R-HSA-198933",
"R-HSA-216083",
"R-HSA-5621575",
"R-HSA-6783783",
"R-HSA-6785807",
"R-HSA-877300",
"R-MMU-198933",
"R-MMU-216083",
"R-RNO-198933",
"R-RNO-216083"
] | [
"REACTOME:R-CFA-198933",
"REACTOME:R-CFA-216083",
"REACTOME:R-HSA-198933",
"REACTOME:R-HSA-216083",
"REACTOME:R-HSA-5621575",
"REACTOME:R-HSA-6783783",
"REACTOME:R-HSA-6785807",
"REACTOME:R-HSA-877300",
"REACTOME:R-MMU-198933",
"REACTOME:R-MMU-216083",
"REACTOME:R-RNO-198933",
"REACTOME:R-RNO-... | 12 | [
"1d3e",
"1d3i",
"1d3l",
"1iam",
"1ic1",
"1mq8",
"1z7z",
"1zxq",
"3bn3",
"4oi9",
"4oia",
"4oib",
"5mza",
"6s8u",
"7bg7"
] | 15 | [
"PUB00007637",
"PUB00007638",
"PUB00007639",
"PUB00007640",
"PUB00007641",
"PUB00007642",
"PUB00009398",
"PUB00009399",
"PUB00009400"
] | [
"10352278",
"10725740",
"10846180",
"10741396",
"11133225",
"7531291",
"9151947",
"10998349",
"9539703"
] | [
"ICAM-2 and a peptide from its binding domain are efficient activators of leukocyte adhesion and integrin affinity.",
"Shear and time-dependent changes in Mac-1, LFA-1, and ICAM-3 binding regulate neutrophil homotypic adhesion.",
"Binding sites of leukocyte beta 2 integrins (LFA-1, Mac-1) on the human ICAM-4/LW... | [
1999,
2000,
2000,
2000,
2001,
1995,
1997,
2000,
1998
] | 9 | [] | [] | 0 | 0 | null | [
"Mammalia"
] | [
760
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
21,
15,
7
] | 3 | true | Domain | Intercellular adhesion molecule | Intercellular adhesion molecule | ICAM | 2 |
IPR003989 | 3,989 | Vascular cell adhesion molecule-1 | VCAM-1 | Family | 1,289 | false | false | Intercellular adhesion molecules (ICAMs) and vascular cell adhesion molecule-1 (VCAM-1) are part of the immunoglobulin superfamily. They are important in inflammation, immune responses and in intracellular signalling events [ ]. The ICAM family consists of five members, designated ICAM-1 to ICAM-5. They are known to bi... | [
"GO:0098609",
"GO:0016020"
] | [
"cell-cell adhesion",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01474"
] | [
"VCAM1"
] | [
1289
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-198933",
"R-HSA-216083",
"R-HSA-6785807",
"R-HSA-877300",
"R-MMU-198933",
"R-MMU-216083",
"R-RNO-198933",
"R-RNO-216083"
] | [
"REACTOME:R-HSA-198933",
"REACTOME:R-HSA-216083",
"REACTOME:R-HSA-6785807",
"REACTOME:R-HSA-877300",
"REACTOME:R-MMU-198933",
"REACTOME:R-MMU-216083",
"REACTOME:R-RNO-198933",
"REACTOME:R-RNO-216083"
] | 8 | [
"1ij9",
"1vca"
] | 2 | [
"PUB00007637",
"PUB00007638",
"PUB00007639",
"PUB00007640",
"PUB00007641",
"PUB00007642",
"PUB00009398",
"PUB00009399",
"PUB00009400"
] | [
"10352278",
"10725740",
"10846180",
"10741396",
"11133225",
"7531291",
"9151947",
"10998349",
"9539703"
] | [
"ICAM-2 and a peptide from its binding domain are efficient activators of leukocyte adhesion and integrin affinity.",
"Shear and time-dependent changes in Mac-1, LFA-1, and ICAM-3 binding regulate neutrophil homotypic adhesion.",
"Binding sites of leukocyte beta 2 integrins (LFA-1, Mac-1) on the human ICAM-4/LW... | [
1999,
2000,
2000,
2000,
2001,
1995,
1997,
2000,
1998
] | 9 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1289
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
6,
7,
4
] | 4 | true | Family | Vascular cell adhesion molecule-1 | Vascular cell adhesion molecule-1 | VCAM-1 | 9 |
IPR003991 | 3,991 | Pertactin virulence factor family | Pertactin_virulence_factor | Family | 4,289 | false | false | Bordetella pertussis is a Gram-negative, aerobic coccobacillus that causes pertussis (whooping cough), especially in young children [ ]. Once present in the lungs, the bacterium attaches to ciliated pulmonary epithelial cells via a collection of outer membrane proteins, all of which are virulence factors. Pertactin, or... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR01484"
] | [
"PRTACTNFAMLY"
] | [
4289
] | 1 | [
"REACTOME"
] | [
"R-HSA-9760173"
] | [
"REACTOME:R-HSA-9760173"
] | 1 | [
"3qq2"
] | 1 | [
"PUB00007646",
"PUB00007647",
"PUB00007648",
"PUB00007649",
"PUB00007650",
"PUB00007651"
] | [
"2542937",
"1527510",
"10943406",
"8609998",
"7476158",
"7927748"
] | [
"Molecular cloning and characterization of protective outer membrane protein P.69 from Bordetella pertussis.",
"Cloning, nucleotide sequence and heterologous expression of the protective outer-membrane protein P.68 pertactin from Bordetella bronchiseptica.",
"Molecular aspects of Bordetella pertussis pathogenes... | [
1989,
1992,
1999,
1996,
1995,
1994
] | 6 | [] | [
"IPR003992"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ct5lU19",
"metagenomes"
] | [
4275,
4,
1,
9
] | 4 | [
"Escherichia coli (strain K12)"
] | [
5
] | 1 | true | Family | Pertactin virulence factor family | Pertactin virulence factor family | Pertactin_virulence_factor | 3 |
IPR003992 | 3,992 | Pertactin autotransporter | Pertactin | Family | 481 | false | false | Pertactin (PRN) is an autotransporter protein produced by all members of the Bordetella bronchiseptica cluster. It functions as an adhesin and that an RGD motif located in the centre of the passenger domain is important for this function [ ]. | [
"GO:0007155"
] | [
"cell adhesion"
] | [
"biological_process"
] | 1 | [
"PRINTS"
] | [
"PR01482"
] | [
"PERTACTIN"
] | [
481
] | 1 | [] | [] | [] | 0 | [
"1dab",
"2iou"
] | 2 | [
"PUB00091100"
] | [
"20421378"
] | [
"Pertactin is required for Bordetella species to resist neutrophil-mediated clearance."
] | [
2010
] | 1 | [
"IPR003991"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota"
] | [
478,
3
] | 2 | [] | [] | 0 | true | Family | Pertactin autotransporter | Pertactin autotransporter | Pertactin | 8 |
IPR003994 | 3,994 | Ubiquitously expressed transcript protein UXT | UXT | Family | 1,153 | false | false | Ubiquitously expressed transcript protein UXT is involved in gene transcription regulation. It acts in concert with the corepressor URI1 to regulate androgen receptor transcription (AR). It is an AR N terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation [ ]. | [
"GO:0003714",
"GO:0000122"
] | [
"transcription corepressor activity",
"negative regulation of transcription by RNA polymerase II"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PRINTS"
] | [
"PR01502"
] | [
"UXTPROTEIN"
] | [
1153
] | 1 | [
"REACTOME"
] | [
"R-HSA-8953750"
] | [
"REACTOME:R-HSA-8953750"
] | 1 | [] | 0 | [
"PUB00013187",
"PUB00013306",
"PUB00015151",
"PUB00015152"
] | [
"12456645",
"11106732",
"11854421",
"15264020"
] | [
"Structure of eukaryotic prefoldin and of its complexes with unfolded actin and the cytosolic chaperonin CCT.",
"Structure of the molecular chaperone prefoldin: unique interaction of multiple coiled coil tentacles with unfolded proteins.",
"Identification and characterization of ART-27, a novel coactivator for ... | [
2002,
2000,
2002,
2004
] | 4 | [
"IPR004127"
] | [] | 1 | 0 | 1 | [
"Eukaryota",
"bird metagenome"
] | [
1152,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
2,
5
] | 4 | true | Family | Ubiquitously expressed transcript protein UXT | Ubiquitously expressed transcript protein UXT | UXT | 4 |
IPR003995 | 3,995 | RTX toxin determinant A | RTX_toxin_determinant-A | Family | 4,925 | false | false | Secretion of virulence factors in Gram-negative bacteria involves transportation of the protein across two membranes to reach the cell exterior [ , ]. Four principal exotoxin secretion systems have been described. In the type II and IV secretion systems, toxins are first exported to the periplasm by way of a cleaved N-... | [
"GO:0005509",
"GO:0005576"
] | [
"calcium ion binding",
"extracellular region"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01488"
] | [
"RTXTOXINA"
] | [
4925
] | 1 | [
"REACTOME"
] | [
"R-HSA-9760173"
] | [
"REACTOME:R-HSA-9760173"
] | 1 | [
"7usl"
] | 1 | [
"PUB00007655",
"PUB00007656",
"PUB00007657",
"PUB00007658",
"PUB00007659",
"PUB00100829",
"PUB00100830"
] | [
"1558765",
"8800842",
"10470043",
"9521785",
"8808931",
"33260488",
"30405113"
] | [
"Structural and functional relationships among the RTX toxin determinants of gram-negative bacteria.",
"Biological effects of RTX toxins: the possible role of lipopolysaccharide.",
"The interaction between RTX toxins and target cells.",
"The biochemistry of hemolysin toxin activation: characterization of HlyC... | [
1992,
1995,
1999,
1998,
1996,
2020,
2018
] | 7 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Nitrososphaerota",
"unclassified sequences"
] | [
4869,
20,
8,
28
] | 4 | [] | [] | 0 | true | Family | RTX toxin determinant A | RTX toxin determinant A | RTX_toxin_determinant-A | 8 |
IPR003996 | 3,996 | RTX toxin-activating protein C, bacteria | RTX_toxin-activating_protC_bac | Family | 1,331 | false | false | Secretion of virulence factors in Gram-negative bacteria involves transportation of the protein across two membranes to reach the cell exterior [ ]. Four principal exotoxin secretion systems have been described. In the type II and IV secretion systems, toxins are first exported to the periplasm by way of a cleaved N-te... | [
"GO:0016746",
"GO:0009404",
"GO:0005737"
] | [
"acyltransferase activity",
"toxin metabolic process",
"cytoplasm"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PRINTS"
] | [
"PF02794",
"PR01489"
] | [
"HlyC",
"RTXTOXINC"
] | [
1331,
729
] | 2 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.3.1.-",
"PWY-3602",
"PWY-361",
"PWY-4801",
"PWY-4922",
"PWY-5048",
"PWY-5139",
"PWY-5268",
"PWY-5284",
"PWY-5292",
"PWY-5307",
"PWY-5313",
"PWY-5317",
"PWY-5318",
"PWY-5353",
"PWY-5400",
"PWY-5473",
"PWY-5475",
"PWY-5477",
"PWY-5660",
"PWY-5679",
"PWY-5710",
"PWY-5794"... | [
"EC:2.3.1.-",
"METACYC:PWY-3602",
"METACYC:PWY-361",
"METACYC:PWY-4801",
"METACYC:PWY-4922",
"METACYC:PWY-5048",
"METACYC:PWY-5139",
"METACYC:PWY-5268",
"METACYC:PWY-5284",
"METACYC:PWY-5292",
"METACYC:PWY-5307",
"METACYC:PWY-5313",
"METACYC:PWY-5317",
"METACYC:PWY-5318",
"METACYC:PWY-53... | 219 | [
"4whn"
] | 1 | [
"PUB00007655",
"PUB00007656",
"PUB00007657",
"PUB00007658",
"PUB00007660"
] | [
"1558765",
"8800842",
"10470043",
"9521785",
"10413532"
] | [
"Structural and functional relationships among the RTX toxin determinants of gram-negative bacteria.",
"Biological effects of RTX toxins: the possible role of lipopolysaccharide.",
"The interaction between RTX toxins and target cells.",
"The biochemistry of hemolysin toxin activation: characterization of HlyC... | [
1992,
1995,
1999,
1998,
1999
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"hydrothermal vent metagenome",
"uncultured Caudovirales phage"
] | [
1327,
2,
1,
1
] | 4 | [] | [] | 0 | true | Family | RTX toxin-activating protein C, bacteria | RTX toxin-activating protein C, bacteria | RTX_toxin-activating_protC_bac | 3 |
IPR004000 | 4,000 | Actin family | Actin | Family | 103,509 | false | false | Actin [ , ] is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. These filaments interact with myosin to produce a sliding effect, which is the basis of muscular contraction and many aspects of cell motility, including cytokinesis. Each actin protomer binds one m... | [] | [] | [] | 0 | [
"PFAM",
"PRINTS",
"PANTHER",
"SMART"
] | [
"PF00022",
"PR00190",
"PTHR11937",
"SM00268"
] | [
"Actin",
"ACTIN",
"",
"ACTIN"
] | [
101444,
56714,
91065,
86779
] | 4 | [
"EC",
"GP",
"METACYC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REAC... | [
"3.6.4.-",
"GenProp2081",
"PWY-7250",
"PDOC00340",
"R-BTA-114608",
"R-BTA-190873",
"R-BTA-196025",
"R-BTA-2029482",
"R-BTA-2132295",
"R-BTA-3214858",
"R-BTA-3371497",
"R-BTA-390522",
"R-BTA-3928662",
"R-BTA-418990",
"R-BTA-4420097",
"R-BTA-445355",
"R-BTA-446353",
"R-BTA-5250924",
... | [
"EC:3.6.4.-",
"GP:GenProp2081",
"METACYC:PWY-7250",
"PROSITEDOC:PDOC00340",
"REACTOME:R-BTA-114608",
"REACTOME:R-BTA-190873",
"REACTOME:R-BTA-196025",
"REACTOME:R-BTA-2029482",
"REACTOME:R-BTA-2132295",
"REACTOME:R-BTA-3214858",
"REACTOME:R-BTA-3371497",
"REACTOME:R-BTA-390522",
"REACTOME:R-... | 387 | [
"1atn",
"1c0f",
"1c0g",
"1d4x",
"1dej",
"1eqy",
"1esv",
"1h1v",
"1hlu",
"1ijj",
"1j6z",
"1k8k",
"1kxp",
"1lcu",
"1lot",
"1m8q",
"1ma9",
"1mdu",
"1mvw",
"1nlv",
"1nm1",
"1nmd",
"1nwk",
"1o18",
"1o19",
"1o1a",
"1o1b",
"1o1c",
"1o1d",
"1o1e",
"1o1f",
"1o1g"... | 731 | [
"PUB00000090",
"PUB00001058",
"PUB00004744",
"PUB00004796"
] | [
"1388079",
"8448030",
"1828889",
"1323828"
] | [
"Structure and function of actin.",
"Actin isoforms.",
"Similarity of the three-dimensional structures of actin and the ATPase fragment of a 70-kDa heat shock cognate protein.",
"An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins."
] | [
1992,
1993,
1991,
1992
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
88,
1768,
101514,
5,
134
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
124,
14,
37,
26,
243,
118,
10,
46,
112,
11,
11,
199
] | 12 | true | Family | Actin family | Actin family | Actin | 5 |
IPR004001 | 4,001 | Actin, conserved site | Actin_CS | Conserved_site | 37,116 | false | false | Actin [ , ] is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. These filaments interact with myosin to produce a sliding effect, which is the basis of muscular contraction and many aspects of cell motility, including cytokinesis. Each actin protomer binds one m... | [] | [] | [] | 0 | [
"PROSITE",
"PROSITE"
] | [
"PS00406",
"PS00432"
] | [
"ACTINS_1",
"ACTINS_2"
] | [
27097,
27699
] | 2 | [
"EC",
"METACYC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.6.4.-",
"PWY-7250",
"PDOC00340",
"R-BTA-114608",
"R-BTA-190873",
"R-BTA-196025",
"R-BTA-2029482",
"R-BTA-2132295",
"R-BTA-3214858",
"R-BTA-390522",
"R-BTA-3928662",
"R-BTA-418990",
"R-BTA-4420097",
"R-BTA-445355",
"R-BTA-446353",
"R-BTA-5250924",
"R-BTA-5626467",
"R-BTA-5663213"... | [
"EC:3.6.4.-",
"METACYC:PWY-7250",
"PROSITEDOC:PDOC00340",
"REACTOME:R-BTA-114608",
"REACTOME:R-BTA-190873",
"REACTOME:R-BTA-196025",
"REACTOME:R-BTA-2029482",
"REACTOME:R-BTA-2132295",
"REACTOME:R-BTA-3214858",
"REACTOME:R-BTA-390522",
"REACTOME:R-BTA-3928662",
"REACTOME:R-BTA-418990",
"REAC... | 358 | [
"1atn",
"1c0f",
"1c0g",
"1d4x",
"1dej",
"1eqy",
"1esv",
"1h1v",
"1hlu",
"1ijj",
"1j6z",
"1kxp",
"1lcu",
"1lot",
"1m8q",
"1ma9",
"1mdu",
"1mvw",
"1nlv",
"1nm1",
"1nmd",
"1nwk",
"1o18",
"1o19",
"1o1a",
"1o1b",
"1o1c",
"1o1d",
"1o1e",
"1o1f",
"1o1g",
"1p8z"... | 639 | [
"PUB00000090",
"PUB00001058",
"PUB00004744",
"PUB00004796"
] | [
"1388079",
"8448030",
"1828889",
"1323828"
] | [
"Structure and function of actin.",
"Actin isoforms.",
"Similarity of the three-dimensional structures of actin and the ATPase fragment of a 70-kDa heat shock cognate protein.",
"An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins."
] | [
1992,
1993,
1991,
1992
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
51,
37053,
4,
8
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
76,
8,
22,
14,
82,
59,
2,
24,
41,
1,
3,
89
] | 12 | true | Conserved_site | Actin, conserved site | Actin, conserved site | Actin_CS | 6 |
IPR004004 | 4,004 | Helicase/polymerase/peptidase polyprotein, Calicivirus-type | Helic/Pol/Pept_Calicivir-typ | Family | 8,832 | false | false | Caliciviruses are positive-stranded ssRNA viruses that cause gastroenteritis [ ]. The calicivirus genome contains two open reading frames, ORF1 and ORF2 [ , ]. ORF1 encodes a non-structural polypeptide, which has RNA helicase, cysteine protease and RNA polymerase activity. The cysteine peptidases of the Calciviruses be... | [
"GO:0003968",
"GO:0004386",
"GO:0005524"
] | [
"RNA-directed RNA polymerase activity",
"helicase activity",
"ATP binding"
] | [
"molecular_function",
"molecular_function",
"molecular_function"
] | 3 | [
"PRINTS"
] | [
"PR00918"
] | [
"CALICVIRUSNS"
] | [
8832
] | 1 | [
"EC",
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.7.7.48",
"3.4.22",
"3.6.1.15",
"PWY-6545",
"PWY-7184",
"PWY-7185",
"PWY-7198",
"PWY-7210"
] | [
"EC:2.7.7.48",
"EC:3.4.22",
"EC:3.6.1.15",
"METACYC:PWY-6545",
"METACYC:PWY-7184",
"METACYC:PWY-7185",
"METACYC:PWY-7198",
"METACYC:PWY-7210"
] | 8 | [
"1khv",
"1khw",
"1sh0",
"1sh2",
"1sh3",
"2b43",
"2ckw",
"2uut",
"2uuw",
"2wk4",
"3bsn",
"3bso",
"3h5x",
"3h5y",
"3nah",
"3nai",
"3qid",
"3sfg",
"3sfu",
"3upf",
"3uqs",
"3ur0",
"4lq3",
"4lq9",
"4nrt",
"4nru",
"4o4r",
"4qpx",
"5tsn",
"5y3d",
"8tuf",
"9r34"... | 32 | [
"PUB00001630",
"PUB00003519",
"PUB00003528",
"PUB00005577"
] | [
"1551442",
"8642693",
"8892921",
"1840711"
] | [
"An insect picornavirus may have genome organization similar to that of caliciviruses.",
"Polyprotein processing in Southampton virus: identification of 3C-like protease cleavage sites by in vitro mutagenesis.",
"Genetic map of the calicivirus rabbit hemorrhagic disease virus as deduced from in vitro translatio... | [
1992,
1996,
1996,
1991
] | 4 | [] | [] | 0 | 0 | null | [
"Amycolatopsis",
"Opisthokonta",
"Viruses",
"viral metagenome"
] | [
15,
16,
8800,
1
] | 4 | [] | [] | 0 | true | Family | Helicase/polymerase/peptidase polyprotein, Calicivirus-type | Helicase/polymerase/peptidase polyprotein, Calicivirus-type | Helic/Pol/Pept_Calicivir-typ | 5 |
IPR004005 | 4,005 | Calicivirus coat protein | Calicivirus_coat | Domain | 41,109 | false | false | Rabbit hemorrhagic disease virus (RHDV) which causes a highly contagious disease of wild and domestic rabbits belongs to the family Caliciviridae [ ]. The capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry. It is about 38nm in diameter and consists of 180 capsid proteins. The capsid encapsu... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF00915"
] | [
"Calici_coat"
] | [
41109
] | 1 | [] | [] | [] | 0 | [
"1ihm",
"2gh8",
"2zl5",
"2zl6",
"2zl7",
"3asp",
"3asq",
"3asr",
"3ass",
"3ast",
"3by1",
"3by2",
"3d26",
"3j1p",
"3m8l",
"3zue",
"4egt",
"4ejr",
"4p12",
"4p1v",
"4p25",
"4p26",
"4p2n",
"4p3i",
"4pb6",
"4rdj",
"4rdk",
"4rdl",
"4rlz",
"4rm0",
"4rpb",
"4x1w"... | 116 | [
"PUB00044072"
] | [
"16733562"
] | [
"Recombinant VP60 in the form of virion-like particles as a potential vaccine against rabbit hemorrhagic disease virus."
] | [
2006
] | 1 | [
"IPR033703"
] | [] | 1 | 0 | 1 | [
"Arthropoda",
"Riboviria"
] | [
6,
41103
] | 2 | [] | [] | 0 | true | Domain | Calicivirus coat protein | Calicivirus coat protein | Calicivirus_coat | 5 |
IPR004006 | 4,006 | DhaK domain | DhaK_dom | Domain | 21,220 | false | false | Dihydroxyacetone (Dha) kinases are a family of sequence-conserved enzymes that phosphorylate dihydroxyacetone, glyceraldehyde and other short-chain ketoses and aldoses. They can be divided into two groups according to the source of high-energy phosphate that they utilise, either ATP or phosphoenolpyruvate (PEP). The AT... | [
"GO:0004371",
"GO:0006071"
] | [
"glycerone kinase activity",
"glycerol metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PROFILE"
] | [
"PF02733",
"PS51481"
] | [
"Dak1",
"DHAK"
] | [
20972,
21190
] | 2 | [
"EC",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.1",
"GenProp1324",
"R-DDI-70350",
"R-HSA-168928",
"R-HSA-70350",
"R-HSA-9692916",
"R-HSA-9705671",
"R-MMU-70350",
"R-RNO-70350",
"R-SCE-70350",
"R-SPO-70350"
] | [
"EC:2.7.1",
"GP:GenProp1324",
"REACTOME:R-DDI-70350",
"REACTOME:R-HSA-168928",
"REACTOME:R-HSA-70350",
"REACTOME:R-HSA-9692916",
"REACTOME:R-HSA-9705671",
"REACTOME:R-MMU-70350",
"REACTOME:R-RNO-70350",
"REACTOME:R-SCE-70350",
"REACTOME:R-SPO-70350"
] | 11 | [
"1oi2",
"1oi3",
"1un8",
"1un9",
"1uod",
"1uoe",
"2iu4",
"2iu6",
"3ct4",
"3pnk",
"3pnl",
"3pnm",
"3pno",
"3pnq",
"4lrx",
"4lry"
] | 16 | [
"PUB00017762",
"PUB00029449",
"PUB00039753",
"PUB00051102"
] | [
"12966101",
"12813127",
"16647083",
"18957416"
] | [
"Crystal structure of the Citrobacter freundii dihydroxyacetone kinase reveals an eight-stranded alpha-helical barrel ATP-binding domain.",
"A mechanism of covalent substrate binding in the x-ray structure of subunit K of the Escherichia coli dihydroxyacetone kinase.",
"Crystal structure of the nucleotide-bindi... | [
2003,
2003,
2006,
2008
] | 4 | [] | [
"IPR012736"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
141,
14354,
6620,
105
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae ... | [
19,
1,
1,
1,
6,
4,
2,
7,
5,
2,
2,
8
] | 12 | true | Domain | DhaK domain | DhaK domain | DhaK_dom | 9 |
IPR004007 | 4,007 | DhaL domain | DhaL_dom | Domain | 30,278 | false | false | Dihydroxyacetone (Dha) kinases are a family of sequence-conserved enzymes that phosphorylate dihydroxyacetone, glyceraldehyde and other short-chain ketoses and aldoses. They can be divided into two groups according to the source of high-energy phosphate that they utilise, either ATP or phosphoenolpyruvate (PEP). The AT... | [
"GO:0004371",
"GO:0006071"
] | [
"glycerone kinase activity",
"glycerol metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF02734",
"PS51480",
"SM01120"
] | [
"Dak2",
"DHAL",
"Dak2"
] | [
29988,
30140,
29614
] | 3 | [
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"GenProp1324",
"R-DDI-70350",
"R-HSA-168928",
"R-HSA-70350",
"R-HSA-9692916",
"R-HSA-9705671",
"R-MMU-70350",
"R-RNO-70350",
"R-SCE-70350",
"R-SPO-70350"
] | [
"GP:GenProp1324",
"REACTOME:R-DDI-70350",
"REACTOME:R-HSA-168928",
"REACTOME:R-HSA-70350",
"REACTOME:R-HSA-9692916",
"REACTOME:R-HSA-9705671",
"REACTOME:R-MMU-70350",
"REACTOME:R-RNO-70350",
"REACTOME:R-SCE-70350",
"REACTOME:R-SPO-70350"
] | 10 | [
"1un8",
"1un9",
"2btd",
"3cr3",
"3pnl",
"4lrz",
"7ed6",
"7ed9",
"7rm7",
"7rzk",
"7snb",
"7uq1",
"7w7h",
"8vip",
"8viq",
"8vir",
"8vit"
] | 17 | [
"PUB00017762",
"PUB00039753",
"PUB00051102"
] | [
"12966101",
"16647083",
"18957416"
] | [
"Crystal structure of the Citrobacter freundii dihydroxyacetone kinase reveals an eight-stranded alpha-helical barrel ATP-binding domain.",
"Crystal structure of the nucleotide-binding subunit DhaL of the Escherichia coli dihydroxyacetone kinase.",
"X-ray structures of the three Lactococcus lactis dihydroxyacet... | [
2003,
2006,
2008
] | 3 | [] | [
"IPR012737"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
138,
23478,
6369,
293
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae ... | [
17,
1,
1,
1,
5,
2,
2,
7,
5,
2,
2,
10
] | 12 | true | Domain | DhaL domain | DhaL domain | DhaL_dom | 3 |
IPR004009 | 4,009 | Myosin, SH3 domain | SH3_Myosin | Domain | 43,813 | false | false | This entry represents the N-terminal in myosin proteins. The myosin N-terminal SH3-like domain may mediate some aspect of the conformational communication that occurs within the myosin head during actin and nucleotide binding. Part of this effect may be mediated through interactions with the neck-associated essential l... | [
"GO:0003774",
"GO:0005524",
"GO:0016459"
] | [
"cytoskeletal motor activity",
"ATP binding",
"myosin complex"
] | [
"molecular_function",
"molecular_function",
"cellular_component"
] | 3 | [
"PFAM",
"PROFILE"
] | [
"PF02736",
"PS51844"
] | [
"Myosin_N",
"SH3_LIKE"
] | [
31716,
43128
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-5627123",
"R-CFA-2029482",
"R-DDI-5627123",
"R-DDI-9013418",
"R-DDI-9013419",
"R-DDI-9013420",
"R-DDI-9013422",
"R-DDI-9013425",
"R-DME-190873",
"R-DME-350480",
"R-DME-445355",
"R-DME-5627123",
"R-DME-9013418",
"R-DME-9013420",
"R-DME-9013422",
"R-HSA-1445148",
"R-HSA-1839117"... | [
"REACTOME:R-BTA-5627123",
"REACTOME:R-CFA-2029482",
"REACTOME:R-DDI-5627123",
"REACTOME:R-DDI-9013418",
"REACTOME:R-DDI-9013419",
"REACTOME:R-DDI-9013420",
"REACTOME:R-DDI-9013422",
"REACTOME:R-DDI-9013425",
"REACTOME:R-DME-190873",
"REACTOME:R-DME-350480",
"REACTOME:R-DME-445355",
"REACTOME:R... | 66 | [
"1b7t",
"1br1",
"1br2",
"1br4",
"1d0x",
"1d0y",
"1d0z",
"1d1a",
"1d1b",
"1d1c",
"1dfk",
"1dfl",
"1fmv",
"1fmw",
"1g8x",
"1i84",
"1jwy",
"1jx2",
"1kk7",
"1kk8",
"1kqm",
"1kwo",
"1l2o",
"1lvk",
"1m8q",
"1mma",
"1mmd",
"1mmg",
"1mmn",
"1mnd",
"1mne",
"1mvw"... | 220 | [
"PUB00039658",
"PUB00088672",
"PUB00088673",
"PUB00088674"
] | [
"15944696",
"16982629",
"17597155",
"20217677"
] | [
"The structure of the myosin VI motor reveals the mechanism of directionality reversal.",
"Functional characterization of the N-terminal region of myosin-2.",
"Evidence for an interaction between the SH3 domain and the N-terminal extension of the essential light chain in class II myosins.",
"Myosin diversity ... | [
2005,
2006,
2007,
2010
] | 4 | [] | [
"IPR057535",
"IPR057772"
] | 0 | 2 | 0 | [
"Bacteria",
"Eukaryota"
] | [
7,
43806
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
103,
11,
133,
25,
85,
78,
2,
40,
87,
3,
4,
123
] | 12 | true | Domain | Myosin, SH3 domain | Myosin, SH3 domain | SH3_Myosin | 1 |
IPR004010 | 4,010 | Double Cache domain 2 | Double_Cache_2 | Domain | 4,445 | false | false | Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins, including the animal dihydropyridine-sensitive voltage-gated Ca2 channel alpha-2delta subunit, and various bacterial chemotaxis receptors. The name Cache comes from CAlcium channels and CHEmotaxi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08269"
] | [
"dCache_2"
] | [
4445
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00007364",
"PUB00017181",
"PUB00078916"
] | [
"11292341",
"11084361",
"27049771"
] | [
"Regulatory potential, phyletic distribution and evolution of ancient, intracellular small-molecule-binding domains.",
"Cache - a signaling domain common to animal Ca(2+)-channel subunits and a class of prokaryotic chemotaxis receptors.",
"Cache Domains That are Homologous to, but Different from PAS Domains Com... | [
2001,
2000,
2016
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
135,
4228,
19,
63
] | 4 | [] | [] | 0 | true | Domain | Double Cache domain 2 | Double Cache domain 2 | Double_Cache_2 | 6 |
IPR004013 | 4,013 | PHP domain | PHP_dom | Domain | 90,580 | false | false | The PHP (Polymerase and Histidinol Phosphatase) domain has four conserved sequence motifs that contain invariant histidine and aspartate residues implicated in metal ion coordination. It is found in alpha-subunit of bacterial DNA polymerase III ( ) and family X DNA polymerases in addition to histidinol phosphatase ( ) ... | [
"GO:0003824"
] | [
"catalytic activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF02811"
] | [
"PHP"
] | [
90580
] | 1 | [
"EC"
] | [
"2.7.7.7"
] | [
"EC:2.7.7.7"
] | 1 | [
"1m65",
"1m68",
"1pb0",
"2hnh",
"2hpi",
"2hpm",
"2hqa",
"2yb1",
"2yb4",
"2yxo",
"2yz5",
"2z4g",
"3au2",
"3au6",
"3auo",
"3b0x",
"3b0y",
"3dcp",
"3e0d",
"3e0f",
"3f2b",
"3f2c",
"3f2d",
"3o0f",
"4gc3",
"4gk8",
"4gx8",
"4gx9",
"4gyf",
"4iqj",
"4jom",
"5fku"... | 43 | [
"PUB00027226",
"PUB00042649"
] | [
"12661000",
"17929834"
] | [
"Crystal structure of the Escherichia coli YcdX protein reveals a trinuclear zinc active site.",
"Crystal structure of monofunctional histidinol phosphate phosphatase from Thermus thermophilus HB8."
] | [
2003,
2007
] | 2 | [] | [
"IPR003141",
"IPR047967",
"IPR049821"
] | 0 | 3 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
2493,
83286,
2762,
373,
1666
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
5,
3,
1,
4,
1,
1,
4
] | 7 | true | Domain | PHP domain | PHP domain | PHP_dom | 4 |
IPR004014 | 4,014 | Cation-transporting P-type ATPase, N-terminal | ATPase_P-typ_cation-transptr_N | Domain | 106,753 | false | false | This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H + ( ), Na + ( ), Ca 2+ ( ), Na + /K + ( ), and H + /K + ( ). In the H + /K + -and Na + /K + -exchange P-ATPases, this domain is found in the catalytic alpha chain. In ga... | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF00690",
"SM00831"
] | [
"Cation_ATPase_N",
"Cation_ATPase_N"
] | [
106333,
95538
] | 2 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"7.2.2",
"R-BTA-418359",
"R-BTA-5578775",
"R-BTA-936837",
"R-CEL-418359",
"R-CEL-5578775",
"R-CEL-936837",
"R-CFA-418359",
"R-CFA-5578775",
"R-CFA-936837",
"R-DDI-418359",
"R-DDI-5578775",
"R-DDI-936837",
"R-DME-418359",
"R-DME-5578775",
"R-DME-936837",
"R-GGA-418359",
"R-GGA-55787... | [
"EC:7.2.2",
"REACTOME:R-BTA-418359",
"REACTOME:R-BTA-5578775",
"REACTOME:R-BTA-936837",
"REACTOME:R-CEL-418359",
"REACTOME:R-CEL-5578775",
"REACTOME:R-CEL-936837",
"REACTOME:R-CFA-418359",
"REACTOME:R-CFA-5578775",
"REACTOME:R-CFA-936837",
"REACTOME:R-DDI-418359",
"REACTOME:R-DDI-5578775",
"... | 42 | [
"1iwo",
"1kju",
"1mhs",
"1su4",
"1t5s",
"1t5t",
"1vfp",
"1wpg",
"1xp5",
"2agv",
"2by4",
"2c88",
"2c8k",
"2c8l",
"2c9m",
"2dqs",
"2ear",
"2eat",
"2eau",
"2o9j",
"2oa0",
"2voy",
"2xzb",
"2yfy",
"2yn9",
"2zbd",
"2zbe",
"2zbf",
"2zbg",
"2zxe",
"3a3y",
"3ar2"... | 257 | [
"PUB00009616",
"PUB00020603",
"PUB00020604",
"PUB00020661",
"PUB00020663",
"PUB00068786",
"PUB00068787",
"PUB00068788",
"PUB00068789",
"PUB00160065",
"PUB00160066"
] | [
"9419228",
"15473999",
"15078220",
"12480547",
"12529322",
"20450191",
"18937357",
"1385979",
"9741106",
"37264943",
"37838176"
] | [
"Evolution of substrate specificities in the P-type ATPase superfamily.",
"The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ratio.",
"Mechanisms of ATPases--a multi-disciplinary approach.",
"Structure determination and conformational chang... | [
1998,
2004,
2004,
2003,
2003,
2010,
2008,
1992,
1998,
2023,
2023
] | 11 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1067,
31848,
73470,
10,
358
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
118,
25,
114,
32,
1,
73,
72,
8,
70,
98,
7,
6,
200
] | 13 | true | Domain | Cation-transporting P-type ATPase, N-terminal | Cation-transporting P-type ATPase, N-terminal | ATPase_P-typ_cation-transptr_N | 8 |
IPR004015 | 4,015 | SKI-interacting protein SKIP, SNW domain | SKI-int_prot_SKIP_SNW-dom | Domain | 5,315 | false | false | SKIP (SKI-interacting protein) is an essential spliceosomal component and transcriptional coregulator, which may provide regulatory coupling of transcription initiation and splicing [ ]. SKIP was identified in a yeast 2-hybrid screen, where it was shown to interact with both the cellular and viral forms of SKI through ... | [
"GO:0000398",
"GO:0005681"
] | [
"mRNA splicing, via spliceosome",
"spliceosomal complex"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF02731"
] | [
"SKIP_SNW"
] | [
5315
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-2173795",
"R-BTA-350054",
"R-BTA-72163",
"R-BTA-8941856",
"R-CEL-2173795",
"R-CEL-72163",
"R-DDI-72163",
"R-DME-2173795",
"R-DME-350054",
"R-DME-72163",
"R-HSA-1912408",
"R-HSA-210744",
"R-HSA-2122947",
"R-HSA-2173795",
"R-HSA-2644606",
"R-HSA-2894862",
"R-HSA-350054",
"R-HS... | [
"REACTOME:R-BTA-2173795",
"REACTOME:R-BTA-350054",
"REACTOME:R-BTA-72163",
"REACTOME:R-BTA-8941856",
"REACTOME:R-CEL-2173795",
"REACTOME:R-CEL-72163",
"REACTOME:R-DDI-72163",
"REACTOME:R-DME-2173795",
"REACTOME:R-DME-350054",
"REACTOME:R-DME-72163",
"REACTOME:R-HSA-1912408",
"REACTOME:R-HSA-21... | 28 | [
"3jb9",
"5gm6",
"5gmk",
"5lj3",
"5lj5",
"5lqw",
"5mps",
"5mq0",
"5mqf",
"5wsg",
"5xjc",
"5y88",
"5ylz",
"5yzg",
"5z56",
"5z57",
"5z58",
"6bk8",
"6exn",
"6ff4",
"6ff7",
"6icz",
"6id0",
"6id1",
"6j6g",
"6j6h",
"6j6n",
"6j6q",
"6qdv",
"6zym",
"7a5p",
"7aav"... | 62 | [
"PUB00043556",
"PUB00043557",
"PUB00043558"
] | [
"15052407",
"11522815",
"10644367"
] | [
"Transcriptional coregulator SNW/SKIP: the concealed tie of dissimilar pathways.",
"Ski interacts with the evolutionarily conserved SNW domain of Skip.",
"A role for SKIP in EBNA2 activation of CBF1-repressed promoters."
] | [
2004,
2001,
2000
] | 3 | [] | [] | 0 | 0 | null | [
"Empedobacter",
"Eukaryota"
] | [
2,
5313
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
3,
1,
1,
2,
11,
4,
1,
4,
3,
1,
1,
6
] | 12 | true | Domain | SKI-interacting protein SKIP, SNW domain | SKI-interacting protein SKIP, SNW domain | SKI-int_prot_SKIP_SNW-dom | 3 |
IPR004017 | 4,017 | Cysteine-rich domain | Cys_rich_dom | Domain | 51,617 | false | false | This domain is usually found in two copies per protein. It contains up to four conserved cysteines. The group includes proteins characterised as: heterodisulphide reductase, subunit B (HrdB, ); lactate utilization protein A (LutA); Fe-S oxidoreductase; glycerol-3-phosphate dehydrogenase subunit C (Anaerobic GlpC); and ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02754"
] | [
"CCG"
] | [
51617
] | 1 | [] | [] | [] | 0 | [
"5odc",
"5odh",
"5odi",
"5odq",
"5odr",
"7bkb",
"7bkc",
"7bkd",
"7bke",
"8rvu",
"8rvv",
"8rvy",
"8rwn",
"9ojn"
] | 14 | [
"PUB00007282"
] | [
"8606183"
] | [
"glc locus of Escherichia coli: characterization of genes encoding the subunits of glycolate oxidase and the glc regulator protein."
] | [
1996
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Sym plasmid",
"unclassified sequences"
] | [
3397,
46630,
67,
1,
1522
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)"
] | [
1,
3
] | 2 | true | Domain | Cysteine-rich domain | Cysteine-rich domain | Cys_rich_dom | 1 |
IPR004018 | 4,018 | RPEL repeat | RPEL_repeat | Repeat | 16,100 | false | false | RPEL repeat (RPxxxEL) containing proteins are found in a wide range of metazoan organisms. RPEL repeats have been shown to be required for unpolymerised actin binding and proteins containing RPEL repeats are able to modify cell shape and/or are important in the regulation of gene expression by the actin cytoskeleton. R... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF02755",
"PS51073",
"SM00707"
] | [
"RPEL",
"RPEL",
"RPEL"
] | [
15102,
15815,
15494
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC51073",
"R-HSA-114608",
"R-HSA-3899300",
"R-HSA-5663220",
"R-HSA-9733709",
"R-MMU-3899300",
"R-MMU-5663220",
"R-RNO-114608"
] | [
"PROSITEDOC:PDOC51073",
"REACTOME:R-HSA-114608",
"REACTOME:R-HSA-3899300",
"REACTOME:R-HSA-5663220",
"REACTOME:R-HSA-9733709",
"REACTOME:R-MMU-3899300",
"REACTOME:R-MMU-5663220",
"REACTOME:R-RNO-114608"
] | 8 | [
"2v51",
"2v52",
"2yje",
"2yjf",
"3tpm",
"3tpq",
"4b1u",
"4b1v",
"4b1w",
"4b1x",
"4b1y",
"4b1z"
] | 12 | [
"PUB00018528",
"PUB00018529"
] | [
"12732141",
"15620697"
] | [
"Actin dynamics control SRF activity by regulation of its coactivator MAL.",
"Overexpression of a family of RPEL proteins modifies cell shape."
] | [
2003,
2005
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
16100
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
6,
100,
15,
41,
34,
1,
59
] | 7 | true | Repeat | RPEL repeat | RPEL repeat | RPEL_repeat | 1 |
IPR004019 | 4,019 | YLP motif | YLP_motif | Conserved_site | 340 | false | false | The YLP motif is found in one or several copies in various Drosophila proteins. Its function is unknown, however the presence of completely conserved tyrosine residues and its presence in the human Erbb-2 and ErbB-4 receptor protein-tyrosine kinases ( ) may suggest it could be a substrate for tyrosine kinases. ErbBs (1... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02757"
] | [
"YLP"
] | [
340
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044083",
"PUB00095316"
] | [
"18721752",
"18793634"
] | [
"System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties.",
"Endocytosis and intracellular trafficking of ErbBs."
] | [
2008,
2008
] | 2 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
340
] | 1 | [
"Drosophila melanogaster"
] | [
14
] | 1 | true | Conserved_site | YLP motif | YLP motif | YLP_motif | 1 |
IPR004020 | 4,020 | DAPIN domain | DAPIN | Domain | 10,205 | false | false | The DAPIN (Domain in Apoptosis and INterferon response) domain is an 80-100- residue domain which is found in the N terminus of diverse vertebrate and vertebrate-specific viral proteins involved in apoptosis, cancer, inflammation, and immune response. The DAPIN domain can be found alone or in association with other dom... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF02758",
"PS50824",
"SM01289"
] | [
"PYRIN",
"DAPIN",
"PYRIN"
] | [
9958,
9465,
9643
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC50824",
"R-BTA-5689901",
"R-BTA-844456",
"R-DRE-111458",
"R-DRE-6798695",
"R-DRE-844455",
"R-DRE-844456",
"R-DRE-9627069",
"R-HSA-1606341",
"R-HSA-1834941",
"R-HSA-1834949",
"R-HSA-3134975",
"R-HSA-3270619",
"R-HSA-5660668",
"R-HSA-5689901",
"R-HSA-6798695",
"R-HSA-844455",
"R... | [
"PROSITEDOC:PDOC50824",
"REACTOME:R-BTA-5689901",
"REACTOME:R-BTA-844456",
"REACTOME:R-DRE-111458",
"REACTOME:R-DRE-6798695",
"REACTOME:R-DRE-844455",
"REACTOME:R-DRE-844456",
"REACTOME:R-DRE-9627069",
"REACTOME:R-HSA-1606341",
"REACTOME:R-HSA-1834941",
"REACTOME:R-HSA-1834949",
"REACTOME:R-HS... | 33 | [
"1pn5",
"1ucp",
"2dbg",
"2do9",
"2hm2",
"2km6",
"2kn6",
"2l6a",
"2m5v",
"2mpc",
"2n00",
"2n1f",
"2naq",
"2yu0",
"3j63",
"3qf2",
"3vd8",
"4ewi",
"4n1j",
"4n1k",
"4n1l",
"4o7q",
"4qob",
"4xhs",
"5gpp",
"5h7n",
"5h7q",
"5wpz",
"5wq6",
"6mb2",
"6ncv",
"6ndj"... | 52 | [
"PUB00018291",
"PUB00018292",
"PUB00018293",
"PUB00057244"
] | [
"11166557",
"11166558",
"11250163",
"1166557"
] | [
"The DAPIN family: a novel domain links apoptotic and interferon response proteins.",
"PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases.",
"The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation.",
"[Practolol (Eraldin ... | [
2001,
2001,
2001,
1975
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Nucleocytoviricota"
] | [
5,
10149,
51
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
97,
114,
77,
42
] | 4 | true | Domain | DAPIN domain | DAPIN domain | DAPIN | 3 |
IPR004021 | 4,021 | HIN-200/IF120x | HIN200/IF120x | Domain | 966 | false | false | This domain is found in one or two copies per protein, and is found associated with the PAAD/DAPIN domain . The HIN domain recognises and interacts with the phosphate backbone of dsDNA in a sequence-independent manner [ , , ]. | [] | [] | [] | 0 | [
"PFAM",
"PROFILE"
] | [
"PF02760",
"PS50834"
] | [
"HIN",
"HIN_200"
] | [
868,
942
] | 2 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC50834",
"R-HSA-1834941",
"R-HSA-1834949",
"R-HSA-3270619",
"R-HSA-6798695",
"R-HSA-844615",
"R-MMU-1834949",
"R-MMU-6798695",
"R-MMU-844615"
] | [
"PROSITEDOC:PDOC50834",
"REACTOME:R-HSA-1834941",
"REACTOME:R-HSA-1834949",
"REACTOME:R-HSA-3270619",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-844615",
"REACTOME:R-MMU-1834949",
"REACTOME:R-MMU-6798695",
"REACTOME:R-MMU-844615"
] | 9 | [
"2oq0",
"3b6y",
"3rln",
"3rlo",
"3rn2",
"3rn5",
"3rnu",
"4jbj",
"4jbk",
"4jbm",
"4l5q",
"4l5r",
"4l5s",
"4l5t",
"4lnq",
"4qgu",
"5yzp",
"5yzw",
"5z7d",
"6oe9",
"8i6k",
"8idx",
"8x70"
] | 23 | [
"PUB00059438",
"PUB00100689",
"PUB00100691"
] | [
"22483801",
"33619523",
"23567559"
] | [
"Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor.",
"Structural mechanism of DNA recognition by the p204 HIN domain.",
"Structural basis for termination of AIM2-mediated signaling by p202."
] | [
2012,
2021,
2013
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
22,
944
] | 2 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
12,
21,
6
] | 3 | true | Domain | HIN-200/IF120x | HIN-200/IF120x | HIN200/IF120x | 1 |
IPR004023 | 4,023 | Mago nashi protein | Mago_nashi | Family | 4,938 | false | false | This family was originally identified in Drosophila and called mago nashi, it is a strict maternal effect, grandchildless-like, gene [ ]. The protein is an integral member of the exon junction complex (EJC). The EJC is a multiprotein complex that is deposited on spliced mRNAs after intron removal at a conserved positio... | [
"GO:0008380",
"GO:0035145"
] | [
"RNA splicing",
"exon-exon junction complex"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PANTHER",
"CDD"
] | [
"PF02792",
"PTHR12638",
"cd11295"
] | [
"Mago_nashi",
"",
"Mago_nashi"
] | [
4938,
4851,
4010
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-159236",
"R-BTA-72163",
"R-BTA-72187",
"R-BTA-73856",
"R-BTA-975957",
"R-CEL-159236",
"R-CEL-72163",
"R-CEL-72187",
"R-CEL-73856",
"R-CEL-975957",
"R-DDI-72163",
"R-DDI-975957",
"R-DME-159236",
"R-DME-72163",
"R-DME-72187",
"R-DME-73856",
"R-DME-975957",
"R-DRE-72163",
"R-... | [
"REACTOME:R-BTA-159236",
"REACTOME:R-BTA-72163",
"REACTOME:R-BTA-72187",
"REACTOME:R-BTA-73856",
"REACTOME:R-BTA-975957",
"REACTOME:R-CEL-159236",
"REACTOME:R-CEL-72163",
"REACTOME:R-CEL-72187",
"REACTOME:R-CEL-73856",
"REACTOME:R-CEL-975957",
"REACTOME:R-DDI-72163",
"REACTOME:R-DDI-975957",
... | 38 | [
"1hl6",
"1oo0",
"1p27",
"1rk8",
"2hyi",
"2j0q",
"2j0s",
"2x1g",
"2xb2",
"3ex7",
"5xjc",
"5yzg",
"6icz",
"6qdv",
"7a5p",
"7w59",
"7w5a",
"7w5b",
"7znj",
"8c6j",
"8i0w",
"9fmd"
] | 22 | [
"PUB00007284",
"PUB00007285",
"PUB00007286",
"PUB00019831",
"PUB00021760",
"PUB00029696",
"PUB00030702",
"PUB00079498",
"PUB00079499",
"PUB00079500",
"PUB00079501",
"PUB00079502",
"PUB00079503",
"PUB00079504",
"PUB00079505",
"PUB00079506",
"PUB00079507"
] | [
"1765008",
"10662555",
"10656761",
"11707413",
"12730685",
"12781131",
"14968132",
"18164611",
"20818392",
"20946982",
"15734573",
"15145352",
"18423193",
"9272960",
"15567724",
"16380844",
"17545126"
] | [
"Mutations in a newly identified Drosophila melanogaster gene, mago nashi, disrupt germ cell formation and result in the formation of mirror-image symmetrical double abdomen embryos.",
"MAGOH interacts with a novel RNA-binding protein.",
"mag-1, a homolog of Drosophila mago nashi, regulates hermaphrodite germ-l... | [
1991,
2000,
2000,
2001,
2003,
2003,
2004,
2008,
2010,
2010,
2005,
2004,
2008,
1997,
2004,
2006,
2007
] | 17 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4938
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (stra... | [
3,
1,
1,
2,
7,
6,
1,
3,
6,
1,
8
] | 11 | true | Family | Mago nashi protein | Mago nashi protein | Mago_nashi | 1 |
IPR004025 | 4,025 | Fungal ribotoxin | Fun_ribotoxin | Family | 54 | false | false | The fungal ribotoxins are a family of highly specific ribonucleases that inactivate the ribosome by cleavage of the 23-28S RNA of the large ribosomal subunit at a single phosphodiester bond. Cleavage abolishes the capacity of ribosomes to carry out protein synthesis by inhibiting elongation factor 1- dependent binding ... | [
"GO:0003723",
"GO:0004540",
"GO:0017148"
] | [
"RNA binding",
"RNA nuclease activity",
"negative regulation of translation"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PRINTS"
] | [
"PR01704"
] | [
"FUNRIBOTOXIN"
] | [
54
] | 1 | [
"EC"
] | [
"3.1.27.-"
] | [
"EC:3.1.27.-"
] | 1 | [
"1aqz",
"1de3",
"1jbr",
"1jbs",
"1jbt",
"1r4y"
] | 6 | [
"PUB00018906"
] | [
"10212236"
] | [
"Molecular dissection of mitogillin reveals that the fungal ribotoxins are a family of natural genetically engineered ribonucleases."
] | [
1999
] | 1 | [
"IPR048269"
] | [] | 1 | 0 | 1 | [
"Dikarya"
] | [
54
] | 1 | [] | [] | 0 | true | Family | Fungal ribotoxin | Fungal ribotoxin | Fun_ribotoxin | 9 |
IPR004026 | 4,026 | Ada DNA repair, metal-binding | Ada_DNA_repair_Zn-bd | Domain | 17,629 | false | false | The Escherichia coli Ada protein repairs O6-methylguanine residues and methyl phosphotriesters in DNA by direct transfer of the methyl group to a cysteine residue. This domain contains four conserved cysteines that form a zinc binding site [ , ]. One of these cysteines is a methyl group acceptor. The methylated domain ... | [
"GO:0003677",
"GO:0008168",
"GO:0008270",
"GO:0006281",
"GO:0006355"
] | [
"DNA binding",
"methyltransferase activity",
"zinc ion binding",
"DNA repair",
"regulation of DNA-templated transcription"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process",
"biological_process"
] | 5 | [
"PFAM"
] | [
"PF02805"
] | [
"Ada_Zn_binding"
] | [
17629
] | 1 | [] | [] | [] | 0 | [
"1adn",
"1eyf",
"1u8b",
"1wpk",
"1zgw"
] | 5 | [
"PUB00007287",
"PUB00007288"
] | [
"1581309",
"8500619"
] | [
"Zinc binding by the methylation signaling domain of the Escherichia coli Ada protein.",
"Folding topology and DNA binding of the N-terminal fragment of Ada protein."
] | [
1992,
1993
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
43,
16430,
1054,
102
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Ada DNA repair, metal-binding | Ada DNA repair, metal-binding | Ada_DNA_repair_Zn-bd | 3 |
IPR004027 | 4,027 | SEC-C motif | SEC_C_motif | Conserved_site | 42,615 | false | false | The SEC-C motif found in the C terminus of the SecA protein, in the middle of some SWI2 ATPases and also solo in several proteins. The motif is predicted to chelate zinc with the CXC and C[HC] pairs that constitute the most conserved feature of the motif. It is predicted to be a potential nucleic acid binding domain. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02810"
] | [
"SEC-C"
] | [
42615
] | 1 | [
"EC",
"REACTOME"
] | [
"7.4.2.8",
"R-HSA-9760173"
] | [
"EC:7.4.2.8",
"REACTOME:R-HSA-9760173"
] | 2 | [
"1ozb",
"1sx0",
"1sx1",
"1tf2",
"1tf5",
"1tm6",
"2i9w",
"2jq5",
"3iqy",
"9l6b",
"9vxg"
] | 11 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
85,
40145,
1486,
13,
886
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
7,
3,
2,
4
] | 4 | true | Conserved_site | SEC-C motif | SEC-C motif | SEC_C_motif | 6 |
IPR004029 | 4,029 | UreE urease accessory, N-terminal | UreE_N | Domain | 7,680 | false | false | The N-terminal domain is termed the peptide-binding domain. Deletion of this domain does not eliminate enzymatic activity, and the truncated protein can still activate urease [ ]. Urease and other nickel metalloenzymes are synthesised as precursors devoid of the metalloenzyme active site. These precursors then undergo ... | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF02814",
"SM00988"
] | [
"UreE_N",
"UreE_N"
] | [
7543,
7565
] | 2 | [
"GP"
] | [
"GenProp0051"
] | [
"GP:GenProp0051"
] | 1 | [
"1ear",
"1eb0",
"1gmu",
"1gmv",
"1gmw",
"3l9z",
"3la0",
"3nxz",
"3ny0",
"3tj8",
"3tj9",
"3tja",
"4l3k"
] | 13 | [
"PUB00015648",
"PUB00015660",
"PUB00015688",
"PUB00015770",
"PUB00015786",
"PUB00015811",
"PUB00015843",
"PUB00015858",
"PUB00016986"
] | [
"12072968",
"11591723",
"11602602",
"11157956",
"10753863",
"12388207",
"8318889",
"7721685",
"15866948"
] | [
"Molecular characterization of Bacillus pasteurii UreE, a metal-binding chaperone for the assembly of the urease active site.",
"Crystal structure of Klebsiella aerogenes UreE, a nickel-binding metallochaperone for urease activation.",
"Structural basis for Ni(2+) transport and assembly of the urease active sit... | [
2002,
2001,
2001,
2001,
2000,
2003,
1993,
1995,
2005
] | 9 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
158,
7456,
2,
64
] | 4 | [] | [] | 0 | true | Domain | UreE urease accessory, N-terminal | UreE urease accessory, N-terminal | UreE_N | 7 |
IPR004030 | 4,030 | Nitric oxide synthase, N-terminal | NOS_N | Domain | 7,522 | false | false | This entry represents the N-terminal of the nitric oxide synthases. Nitric oxide synthase ( ) (NOS) enzymes produce nitric oxide (NO) by catalysing a five-electron oxidation of a guanidino nitrogen of L-arginine (L-Arg). Oxidation of L-Arg to L-citrulline occurs via two successive monooxygenation reactions producing N(... | [
"GO:0004517",
"GO:0006809"
] | [
"nitric-oxide synthase activity",
"nitric oxide biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PROSITE"
] | [
"PF02898",
"PS60001"
] | [
"NO_synthase",
"NOS"
] | [
7509,
5806
] | 2 | [
"EC",
"GP",
"GP",
"METACYC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",... | [
"1.14.13.39",
"GenProp1320",
"GenProp1481",
"PWY-4983",
"PDOC60001",
"R-DME-1222556",
"R-DME-1474151",
"R-DME-203615",
"R-DME-203754",
"R-DME-392154",
"R-DME-5218920",
"R-DME-5578775",
"R-DME-9009391",
"R-DME-9033241",
"R-DME-9856530",
"R-HSA-1222556",
"R-HSA-1474151",
"R-HSA-20361... | [
"EC:1.14.13.39",
"GP:GenProp1320",
"GP:GenProp1481",
"METACYC:PWY-4983",
"PROSITEDOC:PDOC60001",
"REACTOME:R-DME-1222556",
"REACTOME:R-DME-1474151",
"REACTOME:R-DME-203615",
"REACTOME:R-DME-203754",
"REACTOME:R-DME-392154",
"REACTOME:R-DME-5218920",
"REACTOME:R-DME-5578775",
"REACTOME:R-DME-... | 53 | [
"1d0c",
"1d0o",
"1d1v",
"1d1w",
"1d1x",
"1d1y",
"1dd7",
"1df1",
"1dm6",
"1dm7",
"1dm8",
"1dmi",
"1dmj",
"1dmk",
"1dwv",
"1dww",
"1dwx",
"1ed4",
"1ed5",
"1ed6",
"1foi",
"1foj",
"1fol",
"1foo",
"1fop",
"1i83",
"1jwj",
"1jwk",
"1k2r",
"1k2s",
"1k2t",
"1k2u"... | 797 | [
"PUB00007289",
"PUB00007290",
"PUB00007291",
"PUB00007292"
] | [
"8782597",
"7510950",
"9199168",
"7535955"
] | [
"Binding sites of nitric oxide synthases.",
"Nitric oxide synthases in mammals.",
"The first 35 amino acids and fatty acylation sites determine the molecular targeting of endothelial nitric oxide synthase into the Golgi region of cells: a green fluorescent protein study.",
"DHR domains in syntrophins, neurona... | [
1996,
1994,
1997,
1995
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halobacteriales",
"human gut metagenome"
] | [
2581,
4917,
23,
1
] | 4 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
13,
1,
15,
9,
23
] | 5 | true | Domain | Nitric oxide synthase, N-terminal | Nitric oxide synthase, N-terminal | NOS_N | 5 |
IPR004031 | 4,031 | PMP-22/EMP/MP20/Claudin | PMP22/EMP/MP20/Claudin | Family | 50,501 | false | false | This family of evolutionarily related integral membrane proteins includes PMP22, EMP, claudins and voltage-gated calcium channel gamma subunits, many of which perform diverse functions at specialised cell-cell contacts [ ]. Family members from vertebrates and invertebrates are highly divergent. | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PFAM",
"PFAM"
] | [
"PF00822",
"PF13903"
] | [
"PMP22_Claudin",
"Claudin_2"
] | [
36416,
14109
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-399719",
"R-BTA-5682910",
"R-HSA-112308",
"R-HSA-399719",
"R-HSA-420029",
"R-HSA-5576892",
"R-HSA-5576893",
"R-HSA-5682910",
"R-HSA-6803205",
"R-HSA-6809371",
"R-HSA-8935964",
"R-HSA-9619665",
"R-HSA-9856532",
"R-HSA-9925563",
"R-MMU-112308",
"R-MMU-399719",
"R-MMU-5576892",
... | [
"REACTOME:R-BTA-399719",
"REACTOME:R-BTA-5682910",
"REACTOME:R-HSA-112308",
"REACTOME:R-HSA-399719",
"REACTOME:R-HSA-420029",
"REACTOME:R-HSA-5576892",
"REACTOME:R-HSA-5576893",
"REACTOME:R-HSA-5682910",
"REACTOME:R-HSA-6803205",
"REACTOME:R-HSA-6809371",
"REACTOME:R-HSA-8935964",
"REACTOME:R-... | 25 | [
"3jbr",
"3x29",
"4p79",
"5b2g",
"5gjv",
"5gjw",
"5kbs",
"5kbt",
"5kbu",
"5kk2",
"5vot",
"5vou",
"5vov",
"5weo",
"6ake",
"6akf",
"6akg",
"6dlz",
"6dm0",
"6dm1",
"6jp5",
"6jp8",
"6jpa",
"6jpb",
"6njl",
"6njm",
"6njn",
"6o9g",
"6ov2",
"6ov3",
"6qkc",
"6qkz"... | 143 | [
"PUB00070973"
] | [
"24665403"
] | [
"Claudins reign: The claudin/EMP/PMP22/γ channel protein family in C. elegans."
] | [
2013
] | 1 | [] | [
"IPR004032",
"IPR006187",
"IPR008368",
"IPR039625",
"IPR039951"
] | 0 | 5 | 0 | [
"Bacteria",
"Eukaryota",
"viral metagenome"
] | [
9,
50490,
2
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
161,
15,
131,
106,
135
] | 6 | true | Family | PMP-22/EMP/MP20/Claudin | PMP-22/EMP/MP20/Claudin | PMP22/EMP/MP20/Claudin | 8 |
IPR004032 | 4,032 | PMP-22/EMP/MP20 | PMP22_EMP_MP20 | Family | 4,918 | false | false | Several vertebrate small integral membrane glycoproteins are evolutionary related [ , , ], including eye lens specific membrane protein 20 (MP20 or MP19); epithelial membrane protein-1 (EMP-1), which is also known as tumor-associated membrane protein (TMP) or as squamous cell-specific protein Cl-20; epithelial membrane... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PRINTS",
"PROSITE",
"PROSITE"
] | [
"PR01453",
"PS01221",
"PS01222"
] | [
"EPMEMFAMILY",
"PMP22_1",
"PMP22_2"
] | [
3801,
3966,
2728
] | 3 | [
"PROSITEDOC",
"REACTOME"
] | [
"PDOC00939",
"R-HSA-9619665"
] | [
"PROSITEDOC:PDOC00939",
"REACTOME:R-HSA-9619665"
] | 2 | [
"9cbv"
] | 1 | [
"PUB00001869",
"PUB00002934",
"PUB00002936"
] | [
"8996089",
"7499407",
"7499420"
] | [
"Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins.",
"Epithelial membrane protein-1, peripheral myelin protein 22, and lens membrane protein 20 define a novel gene family.",
"Identification and characterization of a novel squamous cell-associated g... | [
1996,
1995,
1995
] | 3 | [
"IPR004031"
] | [
"IPR003932",
"IPR003933",
"IPR003934",
"IPR003935",
"IPR003936"
] | 1 | 5 | 0 | [
"Eumetazoa",
"Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)",
"Pusillimonas minor"
] | [
4916,
1,
1
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
39,
25,
18,
17
] | 4 | true | Family | PMP-22/EMP/MP20 | PMP-22/EMP/MP20 | PMP22_EMP_MP20 | 1 |
IPR004033 | 4,033 | UbiE/COQ5 methyltransferase | UbiE/COQ5_MeTrFase | Family | 27,682 | false | false | This entry represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli [ ] are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of... | [
"GO:0008168"
] | [
"methyltransferase activity"
] | [
"molecular_function"
] | 1 | [
"HAMAP",
"PROFILE",
"NCBIFAM"
] | [
"MF_01813",
"PS51608",
"TIGR01934"
] | [
"MenG_UbiE_methyltr",
"SAM_MT_UBIE",
"MenG_MenH_UbiE"
] | [
25243,
27655,
25560
] | 3 | [
"EC",
"EC",
"GP",
"GP",
"GP",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"PROSITEDOC",
"REACTOME",
"REACTOME... | [
"2.1.1.163",
"2.1.1.201",
"GenProp0058",
"GenProp0136",
"GenProp1291",
"GenProp1498",
"GenProp1744",
"PWY-5839",
"PWY-5844",
"PWY-5849",
"PWY-5855",
"PWY-5856",
"PWY-5857",
"PWY-5870",
"PWY-5871",
"PWY-5872",
"PWY-5873",
"PWY-5890",
"PWY-5891",
"PWY-5892",
"PWY-5895",
"PWY-... | [
"EC:2.1.1.163",
"EC:2.1.1.201",
"GP:GenProp0058",
"GP:GenProp0136",
"GP:GenProp1291",
"GP:GenProp1498",
"GP:GenProp1744",
"METACYC:PWY-5839",
"METACYC:PWY-5844",
"METACYC:PWY-5849",
"METACYC:PWY-5855",
"METACYC:PWY-5856",
"METACYC:PWY-5857",
"METACYC:PWY-5870",
"METACYC:PWY-5871",
"MET... | 35 | [
"4obw",
"4obx"
] | 2 | [
"PUB00002307",
"PUB00013801"
] | [
"9045837",
"8340421"
] | [
"A C-methyltransferase involved in both ubiquinone and menaquinone biosynthesis: isolation and identification of the Escherichia coli ubiE gene.",
"Isolation and functional expression in Escherichia coli of a gene encoding phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides."
] | [
1997,
1993
] | 2 | [] | [
"IPR014122",
"IPR032904"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
62,
21582,
5438,
2,
598
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
6,
1,
1,
2,
1,
5,
2,
1,
7,
2,
1,
1,
20
] | 13 | true | Family | UbiE/COQ5 methyltransferase | UbiE/COQ5 methyltransferase | UbiE/COQ5_MeTrFase | 7 |
IPR004035 | 4,035 | Endonuclease III, iron-sulphur binding site | Endouclease-III_FeS-bd_BS | Binding_site | 26,236 | false | false | Endonuclease III is a DNA repair enzyme which removes a number of damaged pyrimidines from DNA via its glycosylase activity and also cleaves the phosphodiester backbone at apurinic / apyrimidinic sites via a beta-elimination mechanism [ , ]. The structurally related DNA glycosylase MutY recognises and excises the mutat... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS00764"
] | [
"ENDONUCLEASE_III_1"
] | [
26236
] | 1 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC00615",
"R-BTA-110329",
"R-BTA-110357",
"R-CEL-110329",
"R-CEL-110357",
"R-GGA-110329",
"R-HSA-110330",
"R-HSA-110331",
"R-HSA-110357",
"R-HSA-9608287",
"R-HSA-9608290",
"R-MMU-110331",
"R-MMU-110357",
"R-RNO-110331",
"R-RNO-110357",
"R-SPO-110331"
] | [
"PROSITEDOC:PDOC00615",
"REACTOME:R-BTA-110329",
"REACTOME:R-BTA-110357",
"REACTOME:R-CEL-110329",
"REACTOME:R-CEL-110357",
"REACTOME:R-GGA-110329",
"REACTOME:R-HSA-110330",
"REACTOME:R-HSA-110331",
"REACTOME:R-HSA-110357",
"REACTOME:R-HSA-9608287",
"REACTOME:R-HSA-9608290",
"REACTOME:R-MMU-11... | 16 | [
"1kea",
"1kg2",
"1kg3",
"1kg4",
"1kg5",
"1kg6",
"1kg7",
"1mud",
"1mun",
"1muy",
"1wef",
"1weg",
"1wei",
"2abk",
"3n5n",
"4unf",
"7ef8",
"7ef9",
"8a5c",
"8a5f",
"8fay"
] | 21 | [
"PUB00002202",
"PUB00005158",
"PUB00006161",
"PUB00007293",
"PUB00007294",
"PUB00007295",
"PUB00007296"
] | [
"1328155",
"1411536",
"7664751",
"7773744",
"9032058",
"9846876",
"10900127"
] | [
"The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine).",
"Atomic structure of the DNA repair [4Fe-4S] enzyme endonuclease III.",
"Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure.",
"DNA repair prot... | [
1992,
1992,
1995,
1995,
1997,
1998,
2000
] | 7 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
465,
22751,
2579,
1,
440
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
3,
1,
2,
20,
4,
9,
6,
1,
13
] | 9 | true | Binding_site | Endonuclease III, iron-sulphur binding site | Endonuclease III, iron-sulphur binding site | Endouclease-III_FeS-bd_BS | 2 |
IPR004036 | 4,036 | Endonuclease III-like, conserved site-2 | Endonuclease-III-like_CS2 | Conserved_site | 34,777 | false | false | Endonuclease III is a DNA repair enzyme which removes a number of damaged pyrimidines from DNA via its glycosylase activity and also cleaves the phosphodiester backbone at apurinic / apyrimidinic sites via a beta-elimination mechanism [ , ]. The structurally related DNA glycosylase MutY recognises and excises the mutat... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS01155"
] | [
"ENDONUCLEASE_III_2"
] | [
34777
] | 1 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"4.2.99.18",
"PDOC00615",
"R-BTA-110329",
"R-BTA-110357",
"R-CEL-110329",
"R-CEL-110357",
"R-GGA-110329",
"R-HSA-110328",
"R-HSA-110329",
"R-HSA-110330",
"R-HSA-110331",
"R-HSA-110357",
"R-HSA-9608287",
"R-HSA-9608290",
"R-HSA-9630221",
"R-HSA-9630222",
"R-MMU-110329",
"R-MMU-11033... | [
"EC:4.2.99.18",
"PROSITEDOC:PDOC00615",
"REACTOME:R-BTA-110329",
"REACTOME:R-BTA-110357",
"REACTOME:R-CEL-110329",
"REACTOME:R-CEL-110357",
"REACTOME:R-GGA-110329",
"REACTOME:R-HSA-110328",
"REACTOME:R-HSA-110329",
"REACTOME:R-HSA-110330",
"REACTOME:R-HSA-110331",
"REACTOME:R-HSA-110357",
"R... | 24 | [
"1kea",
"1kg2",
"1kg3",
"1kg4",
"1kg5",
"1kg6",
"1kg7",
"1kqj",
"1mud",
"1mun",
"1muy",
"1orn",
"1orp",
"1p59",
"1wef",
"1weg",
"1wei",
"2abk",
"3n5n",
"7ef8",
"7ef9",
"7rds",
"7rdt",
"8fay",
"8uuc"
] | 25 | [
"PUB00002202",
"PUB00005158",
"PUB00006161",
"PUB00007293",
"PUB00007294",
"PUB00007295",
"PUB00007296"
] | [
"1328155",
"1411536",
"7664751",
"7773744",
"9032058",
"9846876",
"10900127"
] | [
"The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine).",
"Atomic structure of the DNA repair [4Fe-4S] enzyme endonuclease III.",
"Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure.",
"DNA repair prot... | [
1992,
1992,
1995,
1995,
1997,
1998,
2000
] | 7 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
412,
28400,
5417,
548
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (stra... | [
6,
1,
3,
2,
2,
26,
6,
1,
9,
2,
2
] | 11 | true | Conserved_site | Endonuclease III-like, conserved site-2 | Endonuclease III-like, conserved site-2 | Endonuclease-III-like_CS2 | 4 |
IPR004037 | 4,037 | Large ribosomal subunit protein eL8-like, conserved site | Ribosomal_eL8-like_CS | Conserved_site | 12,433 | false | false | This entry includes large ribosomal subunit protein eL8 (in human is also known as L7a and in yeast is also known as L4) [ , , ] and several other ribosomal proteins that have been found to share sequence similarity with eL8/L7a, including Saccharomyces cerevisiae NHP2 [ , ], NHP2-like proteins and Bacillus subtilis RN... | [
"GO:0042254",
"GO:1990904"
] | [
"ribosome biogenesis",
"ribonucleoprotein complex"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PROSITE"
] | [
"PS01082"
] | [
"RIBOSOMAL_L7AE"
] | [
12433
] | 1 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00831",
"R-BTA-156827",
"R-BTA-1799339",
"R-BTA-6791226",
"R-BTA-72163",
"R-BTA-72689",
"R-BTA-72706",
"R-BTA-975956",
"R-BTA-975957",
"R-CEL-156827",
"R-CEL-1799339",
"R-CEL-6791226",
"R-CEL-72689",
"R-CEL-72706",
"R-CEL-975956",
"R-CEL-975957",
"R-DDI-156827",
"R-DDI-1799339... | [
"PROSITEDOC:PDOC00831",
"REACTOME:R-BTA-156827",
"REACTOME:R-BTA-1799339",
"REACTOME:R-BTA-6791226",
"REACTOME:R-BTA-72163",
"REACTOME:R-BTA-72689",
"REACTOME:R-BTA-72706",
"REACTOME:R-BTA-975956",
"REACTOME:R-BTA-975957",
"REACTOME:R-CEL-156827",
"REACTOME:R-CEL-1799339",
"REACTOME:R-CEL-6791... | 75 | [
"1e7k",
"1ffk",
"1jj2",
"1k73",
"1k8a",
"1k9m",
"1kc8",
"1kd1",
"1kqs",
"1m1k",
"1m90",
"1n8r",
"1nji",
"1pxw",
"1q7y",
"1q81",
"1q82",
"1q86",
"1qvf",
"1qvg",
"1ra4",
"1rlg",
"1s72",
"1sds",
"1vq4",
"1vq5",
"1vq6",
"1vq7",
"1vq8",
"1vq9",
"1vqk",
"1vql"... | 786 | [
"PUB00000574",
"PUB00003742",
"PUB00004372",
"PUB00005644",
"PUB00007068",
"PUB00007069",
"PUB00007070",
"PUB00053438",
"PUB00058488"
] | [
"1756182",
"2046660",
"2183194",
"2063628",
"11297922",
"11290319",
"11114498",
"9848653",
"22355167"
] | [
"The organization and expression of the human L7a ribosomal protein gene.",
"The organization and expression of the Saccharomyces cerevisiae L4 ribosomal protein genes and their identification as the homologues of the mammalian ribosomal protein gene L7a.",
"Ribosomal protein L4 of Saccharomyces cerevisiae: the... | [
1991,
1991,
1990,
1991,
2001,
2001,
2000,
1998,
2012
] | 9 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Colneyvirus",
"Eukaryota",
"ecological metagenomes"
] | [
305,
127,
5,
11987,
9
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
18,
3,
3,
4,
9,
7,
3,
10,
25,
4,
2,
27
] | 12 | true | Conserved_site | Large ribosomal subunit protein eL8-like, conserved site | Large ribosomal subunit protein eL8-like, conserved site | Ribosomal_eL8-like_CS | 9 |
IPR004038 | 4,038 | Ribosomal protein eL8/eL30/eS12/Gadd45 | Ribosomal_eL8/eL30/eS12/Gad45 | Domain | 44,736 | false | false | This family includes: the metazoan large ribosomal subunit protein eL8 (known as L7A), the fungal ribosomal eL8-A and eL8-B, the eukaryotic small ribosomal subunit protein eS12 (known as S12), the eukaryotic and archaeal large ribosomal subunit protein eL30 (known as L30), Gadd45 and other closely related proteins [ ].... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01248"
] | [
"Ribosomal_L7Ae"
] | [
44736
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-156827",
"R-BTA-171319",
"R-BTA-1799339",
"R-BTA-6791226",
"R-BTA-6804114",
"R-BTA-72163",
"R-BTA-72649",
"R-BTA-72689",
"R-BTA-72695",
"R-BTA-72702",
"R-BTA-72706",
"R-BTA-975956",
"R-BTA-975957",
"R-CEL-156827",
"R-CEL-1799339",
"R-CEL-6791226",
"R-CEL-72649",
"R-CEL-72689... | [
"REACTOME:R-BTA-156827",
"REACTOME:R-BTA-171319",
"REACTOME:R-BTA-1799339",
"REACTOME:R-BTA-6791226",
"REACTOME:R-BTA-6804114",
"REACTOME:R-BTA-72163",
"REACTOME:R-BTA-72649",
"REACTOME:R-BTA-72689",
"REACTOME:R-BTA-72695",
"REACTOME:R-BTA-72702",
"REACTOME:R-BTA-72706",
"REACTOME:R-BTA-975956... | 134 | [
"1ck2",
"1cn7",
"1e7k",
"1ffk",
"1go0",
"1go1",
"1h7m",
"1jj2",
"1k73",
"1k8a",
"1k9m",
"1kc8",
"1kd1",
"1kqs",
"1m1k",
"1m90",
"1n8r",
"1nji",
"1nmu",
"1pxw",
"1q7y",
"1q81",
"1q82",
"1q86",
"1qvf",
"1qvg",
"1ra4",
"1rlg",
"1s72",
"1sds",
"1t0k",
"1vq4"... | 1,037 | [
"PUB00007068",
"PUB00007069",
"PUB00007070",
"PUB00007297"
] | [
"11297922",
"11290319",
"11114498",
"9151207"
] | [
"Atomic structures at last: the ribosome in 2000.",
"The ribosome in focus.",
"The end of the beginning: structural studies of ribosomal proteins.",
"Cell cycle and apoptosis: possible roles of Gadd45 and MyD118 proteins inferred from their homology to ribosomal proteins."
] | [
2001,
2001,
2000,
1997
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
1480,
6657,
36465,
134
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
43,
7,
22,
13,
38,
32,
5,
31,
86,
6,
7,
94
] | 12 | true | Domain | Ribosomal protein eL8/eL30/eS12/Gadd45 | Ribosomal protein eL8/eL30/eS12/Gadd45 | Ribosomal_eL8/eL30/eS12/Gad45 | 7 |
IPR004041 | 4,041 | NAF domain | NAF_dom | Domain | 15,511 | false | false | The NAF domain is a 24 amino acid domain that is found in a plant-specific subgroup of serine-threonine protein kinases (CIPKs), that interact with calcineurin B-like calcium sensor proteins (CBLs). Whereas the N-terminal part of CIPKs comprises a conserved catalytic domain typical of Ser-Thr kinases, the much less con... | [
"GO:0007165"
] | [
"signal transduction"
] | [
"biological_process"
] | 1 | [
"PFAM"
] | [
"PF03822"
] | [
"NAF"
] | [
15511
] | 1 | [
"EC",
"PROSITEDOC"
] | [
"2.7.11.1",
"PDOC50816"
] | [
"EC:2.7.11.1",
"PROSITEDOC:PDOC50816"
] | 2 | [
"2ehb",
"2zfd",
"4czt",
"4czu",
"4d28"
] | 5 | [
"PUB00007298"
] | [
"11230129"
] | [
"The NAF domain defines a novel protein-protein interaction module conserved in Ca2+-regulated kinases."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
15511
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
106,
113,
211
] | 3 | true | Domain | NAF domain | NAF domain | NAF_dom | 9 |
IPR004042 | 4,042 | Intein DOD homing endonuclease, central region | Intein_endonuc_central | Domain | 10,193 | false | false | Inteins (for INternal proTEINs) are in frame intervening sequences that disrupt the coding region of a host gene. They are post-translationally excised from a protein precursor by a self-catalytic protein splicing process [ , , ]. Most inteins are bifunctional proteins mediating both protein splicing and DNA cleavage. ... | [
"GO:0004519"
] | [
"endonuclease activity"
] | [
"molecular_function"
] | 1 | [
"PROFILE"
] | [
"PS50819"
] | [
"INTEIN_ENDONUCLEASE"
] | [
10193
] | 1 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC50819",
"R-SCE-1222556",
"R-SCE-77387",
"R-SCE-917977",
"R-SCE-9639288"
] | [
"PROSITEDOC:PDOC50819",
"REACTOME:R-SCE-1222556",
"REACTOME:R-SCE-77387",
"REACTOME:R-SCE-917977",
"REACTOME:R-SCE-9639288"
] | 5 | [
"1b24",
"1dfa",
"1dq3",
"1ef0",
"1jva",
"1lws",
"1lwt",
"1mow",
"1um2",
"1vde",
"2cw7",
"2cw8",
"2dch",
"2vs7",
"2vs8",
"4d6n",
"4d6o",
"4un7",
"4un8",
"4un9",
"4una",
"4unb",
"4unc",
"4ut0",
"5a0w",
"5ak9",
"5akf",
"5akm",
"5akn",
"5o6g",
"5o6i",
"7qss"... | 35 | [
"PUB00004478",
"PUB00006563",
"PUB00007299",
"PUB00007300",
"PUB00007301"
] | [
"9254693",
"10487208",
"11092822",
"9092614",
"10592269"
] | [
"Homing endonucleases: keeping the house in order.",
"Homing endonucleases: structure, function and evolution.",
"Protein-splicing intein: Genetic mobility, origin, and evolution.",
"Compilation and analysis of intein sequences.",
"InBase, the Intein Database."
] | [
1997,
1999,
2000,
1997,
2000
] | 5 | [] | [
"IPR015147"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1560,
6608,
766,
607,
652
] | 5 | [
"Arabidopsis thaliana",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
2
] | 2 | true | Domain | Intein DOD homing endonuclease, central region | Intein DOD homing endonuclease, central region | Intein_endonuc_central | 5 |
IPR004043 | 4,043 | LCCL domain | LCCL | Domain | 10,682 | false | false | The LCCL domain has been named after the best characterised proteins that were found to contain it, namely Limulus factor C, Coch-5b2 and Lgl1. It is an about 100 amino acids domain whose C-terminal part contains a highly conserved histidine in a conserved motif YxxxSxxCxAAVHxGVI. The LCCL module is thought to be an au... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF03815",
"PS50820",
"SM00603"
] | [
"LCCL",
"LCCL",
"LCCL"
] | [
10644,
10289,
9687
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC50820",
"R-BTA-6798695",
"R-HSA-6798695",
"R-MMU-6798695"
] | [
"PROSITEDOC:PDOC50820",
"REACTOME:R-BTA-6798695",
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-6798695"
] | 4 | [
"1jbi"
] | 1 | [
"PUB00007302",
"PUB00007303",
"PUB00007304",
"PUB00019778"
] | [
"10971586",
"9806553",
"10362728",
"11574466"
] | [
"The LCCL module.",
"Mutations in a novel cochlear gene cause DFNA9, a human nonsyndromic deafness with vestibular dysfunction.",
"A novel developmentally regulated gene in lung mesenchyme: homology to a tumor-derived trypsin inhibitor.",
"NMR structure of the LCCL domain and implications for DFNA9 deafness d... | [
2000,
1998,
1999,
2001
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Klosneuvirus KNV1",
"bioreactor metagenome"
] | [
213,
10464,
1,
4
] | 4 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
33,
20,
8,
2,
25,
1
] | 6 | true | Domain | LCCL domain | LCCL domain | LCCL | 4 |
IPR004044 | 4,044 | K Homology domain, type 2 | KH_dom_type_2 | Domain | 69,196 | false | false | The K homology (KH) domain was first identified in the human heterogeneous nuclear ribonucleoprotein (hnRNP) K. It is a domain of around 70 amino acids that is present in a wide variety of quite diverse nucleic acid-binding proteins [ ]. It has been shown to bind RNA [ , ]. Like many other RNA-binding motifs, KH motifs... | [
"GO:0003723"
] | [
"RNA binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE"
] | [
"PF07650",
"PS50823"
] | [
"KH_2",
"KH_TYPE_2"
] | [
59922,
64611
] | 2 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC50084",
"R-BTA-156827",
"R-BTA-1799339",
"R-BTA-5389840",
"R-BTA-5419276",
"R-BTA-6791226",
"R-BTA-72649",
"R-BTA-72689",
"R-BTA-72695",
"R-BTA-72702",
"R-BTA-72706",
"R-BTA-975956",
"R-BTA-975957",
"R-BTA-9937383",
"R-CEL-156827",
"R-CEL-1799339",
"R-CEL-72649",
"R-CEL-72689"... | [
"PROSITEDOC:PDOC50084",
"REACTOME:R-BTA-156827",
"REACTOME:R-BTA-1799339",
"REACTOME:R-BTA-5389840",
"REACTOME:R-BTA-5419276",
"REACTOME:R-BTA-6791226",
"REACTOME:R-BTA-72649",
"REACTOME:R-BTA-72689",
"REACTOME:R-BTA-72695",
"REACTOME:R-BTA-72702",
"REACTOME:R-BTA-72706",
"REACTOME:R-BTA-97595... | 122 | [
"1ega",
"1fjg",
"1hnw",
"1hnx",
"1hnz",
"1hr0",
"1i94",
"1i95",
"1i96",
"1i97",
"1ibk",
"1ibl",
"1ibm",
"1j5e",
"1jgo",
"1jgp",
"1jgq",
"1ml5",
"1n32",
"1n33",
"1n34",
"1n36",
"1vvj",
"1vy4",
"1vy5",
"1vy6",
"1vy7",
"1wf3",
"1wh9",
"1x18",
"1x1l",
"1xmo"... | 1,721 | [
"PUB00005188",
"PUB00005961",
"PUB00005962",
"PUB00007305"
] | [
"8036511",
"9302998",
"10369774",
"11160884"
] | [
"Conserved structures and diversity of functions of RNA-binding proteins.",
"The solution structure of the first KH domain of FMR1, the protein responsible for the fragile X syndrome.",
"High precision solution structure of the C-terminal KH domain of heterogeneous nuclear ribonucleoprotein K, a c-myc transcrip... | [
1994,
1997,
1999,
2001
] | 4 | [
"IPR004087"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
2263,
47788,
17902,
2,
1241
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
21,
1,
2,
3,
2,
10,
12,
1,
9,
23,
1,
1,
28
] | 13 | true | Domain | K Homology domain, type 2 | K Homology domain, type 2 | KH_dom_type_2 | 4 |
IPR004045 | 4,045 | Glutathione S-transferase, N-terminal | Glutathione_S-Trfase_N | Domain | 244,301 | false | false | This entry represents the N-terminal domain of GST. In eukaryotes, glutathione S-transferases (GSTs) participate in the detoxification of reactive electrophilic compounds by catalysing their conjugation to glutathione. The GST domain is also found in S-crystallins from squid, and proteins with no known GST activity, su... | [] | [] | [] | 0 | [
"PFAM",
"PFAM",
"PFAM",
"PROFILE"
] | [
"PF02798",
"PF13409",
"PF13417",
"PS50404"
] | [
"GST_N",
"GST_N_2",
"GST_N_3",
"GST_NTER"
] | [
99223,
80250,
54630,
219852
] | 4 | [
"EC",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"... | [
"2.5.1.18",
"GenProp1603",
"PWY-4061",
"PWY-6842",
"PWY-7112",
"PWY-7533",
"R-BTA-156590",
"R-BTA-189483",
"R-BTA-9603798",
"R-BTA-9748787",
"R-BTA-9753281",
"R-CEL-156581",
"R-CEL-156590",
"R-CEL-196836",
"R-CEL-204174",
"R-CEL-3299685",
"R-CEL-6798695",
"R-CEL-8963684",
"R-CEL-... | [
"EC:2.5.1.18",
"GP:GenProp1603",
"METACYC:PWY-4061",
"METACYC:PWY-6842",
"METACYC:PWY-7112",
"METACYC:PWY-7533",
"REACTOME:R-BTA-156590",
"REACTOME:R-BTA-189483",
"REACTOME:R-BTA-9603798",
"REACTOME:R-BTA-9748787",
"REACTOME:R-BTA-9753281",
"REACTOME:R-CEL-156581",
"REACTOME:R-CEL-156590",
... | 98 | [
"10gs",
"11gs",
"12gs",
"13gs",
"14gs",
"16gs",
"17gs",
"18gs",
"19gs",
"1a0f",
"1ags",
"1aqv",
"1aqw",
"1aqx",
"1aw9",
"1axd",
"1b48",
"1b4p",
"1b8x",
"1bay",
"1bg5",
"1bx9",
"1bye",
"1c72",
"1dug",
"1e6b",
"1eem",
"1eog",
"1eoh",
"1ev4",
"1ev9",
"1f2e"... | 789 | [
"PUB00007306",
"PUB00007307",
"PUB00007308",
"PUB00007309",
"PUB00007310",
"PUB00007311",
"PUB00021969",
"PUB00043691"
] | [
"9074797",
"10783391",
"11035031",
"10416260",
"11327815",
"9045797",
"12211029",
"16399376"
] | [
"Structure, catalytic mechanism, and evolution of the glutathione transferases.",
"Identification, characterization, and crystal structure of the Omega class glutathione transferases.",
"The glutathione transferase structural family includes a nuclear chloride channel and a ryanodine receptor calcium release ch... | [
1997,
2000,
2001,
1999,
2001,
1997,
2002,
2005
] | 8 | [] | [
"IPR034333",
"IPR034341",
"IPR034345",
"IPR040075"
] | 0 | 4 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1518,
125373,
116120,
56,
1234
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
243,
60,
30,
75,
10,
136,
87,
11,
229,
122,
9,
7,
388
] | 13 | true | Domain | Glutathione S-transferase, N-terminal | Glutathione S-transferase, N-terminal | Glutathione_S-Trfase_N | 9 |
IPR004046 | 4,046 | Glutathione S-transferase, C-terminal | GST_C | Domain | 132,213 | false | false | In eukaryotes, glutathione S-transferases (GSTs) participate in the detoxification of reactive electrophilic compounds by catalysing their conjugation to glutathione. The GST domain is also found in S-crystallins from squid, and proteins with no known GST activity, such as eukaryotic elongation factors 1-gamma and the ... | [] | [] | [] | 0 | [
"PFAM",
"PFAM"
] | [
"PF00043",
"PF14497"
] | [
"GST_C",
"GST_C_3"
] | [
100905,
31414
] | 2 | [
"EC",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"... | [
"2.5.1.18",
"GenProp1603",
"PWY-4061",
"PWY-6842",
"PWY-7112",
"PWY-7533",
"R-BTA-156590",
"R-BTA-189483",
"R-BTA-9748787",
"R-BTA-9753281",
"R-BTA-9856649",
"R-CEL-156581",
"R-CEL-156590",
"R-CEL-196836",
"R-CEL-204174",
"R-CEL-3299685",
"R-CEL-6798695",
"R-CEL-8963684",
"R-CEL-... | [
"EC:2.5.1.18",
"GP:GenProp1603",
"METACYC:PWY-4061",
"METACYC:PWY-6842",
"METACYC:PWY-7112",
"METACYC:PWY-7533",
"REACTOME:R-BTA-156590",
"REACTOME:R-BTA-189483",
"REACTOME:R-BTA-9748787",
"REACTOME:R-BTA-9753281",
"REACTOME:R-BTA-9856649",
"REACTOME:R-CEL-156581",
"REACTOME:R-CEL-156590",
... | 97 | [
"10gs",
"11gs",
"12gs",
"13gs",
"14gs",
"16gs",
"17gs",
"18gs",
"19gs",
"1a0f",
"1ags",
"1aqv",
"1aqw",
"1aqx",
"1aw9",
"1axd",
"1b48",
"1b4p",
"1b8x",
"1bay",
"1bg5",
"1bx9",
"1bye",
"1c72",
"1dug",
"1e6b",
"1eem",
"1eog",
"1eoh",
"1ev4",
"1ev9",
"1f2e"... | 616 | [
"PUB00007306",
"PUB00007307",
"PUB00007308",
"PUB00007309",
"PUB00007310",
"PUB00007311"
] | [
"9074797",
"10783391",
"11035031",
"10416260",
"11327815",
"9045797"
] | [
"Structure, catalytic mechanism, and evolution of the glutathione transferases.",
"Identification, characterization, and crystal structure of the Omega class glutathione transferases.",
"The glutathione transferase structural family includes a nuclear chloride channel and a ryanodine receptor calcium release ch... | [
1997,
2000,
2001,
1999,
2001,
1997
] | 6 | [
"IPR010987"
] | [
"IPR034342",
"IPR034346",
"IPR034347",
"IPR040077"
] | 1 | 4 | 0 | [
"Bacteria",
"Eukaryota",
"Mimiviridae",
"unclassified sequences",
"uncultured Poseidoniia archaeon"
] | [
54982,
76707,
2,
521,
1
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
139,
61,
31,
66,
5,
100,
70,
5,
116,
126,
6,
6,
152
] | 13 | true | Domain | Glutathione S-transferase, C-terminal | Glutathione S-transferase, C-terminal | GST_C | 8 |
IPR004047 | 4,047 | Melanin-concentrating hormone receptor 1 | MCHR1 | Family | 1,021 | false | false | Melanin-concentrating hormone (MCH) is a cyclic peptide originally identified in teleost fish [ ]. In fish, MCH is released from the pituitary and causes lightening of skin pigment cells through pigment aggregation [ , ]. In mammals, MCH is predominantly expressed in the hypothalamus, and functions as a neurotransmitte... | [
"GO:0030273",
"GO:0007218",
"GO:0016020"
] | [
"melanin-concentrating hormone receptor activity",
"neuropeptide signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01507"
] | [
"MCH1RECEPTOR"
] | [
1021
] | 1 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"280",
"R-HSA-375276",
"R-HSA-416476",
"R-HSA-418594",
"R-HSA-5620922",
"R-MMU-375276",
"R-MMU-416476",
"R-MMU-418594",
"R-MMU-5620922",
"R-RNO-375276",
"R-RNO-416476",
"R-RNO-418594",
"R-RNO-5620922",
"R-SSC-375276",
"R-SSC-416476",
"R-SSC-418594",
"R-SSC-5620922"
] | [
"IUPHAR:280",
"REACTOME:R-HSA-375276",
"REACTOME:R-HSA-416476",
"REACTOME:R-HSA-418594",
"REACTOME:R-HSA-5620922",
"REACTOME:R-MMU-375276",
"REACTOME:R-MMU-416476",
"REACTOME:R-MMU-418594",
"REACTOME:R-MMU-5620922",
"REACTOME:R-RNO-375276",
"REACTOME:R-RNO-416476",
"REACTOME:R-RNO-418594",
"... | 17 | [
"8wss",
"8wwh",
"8wwi",
"8wwj",
"8wwk",
"8wwl",
"8wwm",
"8wwn",
"8yns",
"8ynt"
] | 10 | [
"PUB00000131",
"PUB00002477",
"PUB00004960",
"PUB00004961",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816",
"PUB00095299",
"PUB00095311"
] | [
"2111655",
"2830256",
"8386361",
"8170923",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293",
"23626585",
"27152164"
] | [
"G proteins in signal transduction.",
"G protein involvement in receptor-effector coupling.",
"Design of a discriminating fingerprint for G-protein-coupled receptors.",
"Fingerprinting G-protein-coupled receptors.",
"The G protein-coupled receptor repertoires of human and mouse.",
"GCRDb: a G-protein-coup... | [
1990,
1988,
1993,
1994,
2003,
1994,
2005,
2009,
2006,
2013,
2013,
2014
] | 12 | [
"IPR008361"
] | [] | 1 | 0 | 1 | [
"Deuterostomia"
] | [
1021
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
4,
1,
1
] | 4 | true | Family | Melanin-concentrating hormone receptor 1 | Melanin-concentrating hormone receptor 1 | MCHR1 | 9 |
IPR004048 | 4,048 | Potassium channel, voltage dependent, Kv1.1 | K_chnl_volt-dep_Kv1.1 | Family | 948 | false | false | Potassium channels are the most diverse group of the ion channel family [ , ]. They are important in shaping the action potential, and in neuronal excitability and plasticity [ ]. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups [ ]: the pr... | [
"GO:0005249",
"GO:0006813",
"GO:0008076"
] | [
"voltage-gated potassium channel activity",
"potassium ion transport",
"voltage-gated potassium channel complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01508"
] | [
"KV11CHANNEL"
] | [
948
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1296072",
"R-MMU-1296072",
"R-RNO-1296072"
] | [
"REACTOME:R-HSA-1296072",
"REACTOME:R-MMU-1296072",
"REACTOME:R-RNO-1296072"
] | 3 | [] | 0 | [
"PUB00001055",
"PUB00001622",
"PUB00002771",
"PUB00004011",
"PUB00004020",
"PUB00006577",
"PUB00007312",
"PUB00007313",
"PUB00008322",
"PUB00009378",
"PUB00009391",
"PUB00036044"
] | [
"1772658",
"1879548",
"1373731",
"2448635",
"2451788",
"2555158",
"10798390",
"10428758",
"9305895",
"11178249",
"10712896",
"11343973"
] | [
"The molecular biology of K+ channels.",
"Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.",
"Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.",
"Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso... | [
1991,
1991,
1992,
1988,
1988,
1989,
2000,
1999,
1997,
2000,
2000,
2000
] | 12 | [
"IPR003972"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
948
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
2,
4,
2
] | 5 | true | Family | Potassium channel, voltage dependent, Kv1.1 | Potassium channel, voltage dependent, Kv1.1 | K_chnl_volt-dep_Kv1.1 | 5 |
IPR004049 | 4,049 | Potassium channel, voltage dependent, Kv1.2 | K_chnl_volt-dep_Kv1.2 | Family | 998 | false | false | Potassium channels are the most diverse group of the ion channel family [ , ]. They are important in shaping the action potential, and in neuronal excitability and plasticity [ ]. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups [ ]: the pr... | [
"GO:0005249",
"GO:0006813",
"GO:0008076"
] | [
"voltage-gated potassium channel activity",
"potassium ion transport",
"voltage-gated potassium channel complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01509"
] | [
"KV12CHANNEL"
] | [
998
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1296072",
"R-MMU-1296072",
"R-RNO-1296072"
] | [
"REACTOME:R-HSA-1296072",
"REACTOME:R-MMU-1296072",
"REACTOME:R-RNO-1296072"
] | 3 | [
"2a79",
"2r9r",
"3lnm",
"3lut",
"4jta",
"4jtc",
"4jtd",
"5wie",
"6ebk",
"6ebl",
"6ebm",
"7sit",
"7siz",
"8vc3",
"8vc4",
"8vc6",
"8vch"
] | 17 | [
"PUB00001055",
"PUB00001622",
"PUB00002771",
"PUB00004011",
"PUB00004020",
"PUB00006577",
"PUB00007312",
"PUB00008322",
"PUB00009378",
"PUB00009391",
"PUB00036044"
] | [
"1772658",
"1879548",
"1373731",
"2448635",
"2451788",
"2555158",
"10798390",
"9305895",
"11178249",
"10712896",
"11343973"
] | [
"The molecular biology of K+ channels.",
"Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.",
"Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.",
"Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso... | [
1991,
1991,
1992,
1988,
1988,
1989,
2000,
1997,
2000,
2000,
2000
] | 11 | [
"IPR003972"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
998
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
4,
1,
2
] | 4 | true | Family | Potassium channel, voltage dependent, Kv1.2 | Potassium channel, voltage dependent, Kv1.2 | K_chnl_volt-dep_Kv1.2 | 3 |
IPR004050 | 4,050 | Potassium channel, voltage dependent, Kv1.3 | K_chnl_volt-dep_Kv1.3 | Family | 684 | false | false | Potassium channels are the most diverse group of the ion channel family [ , ]. They are important in shaping the action potential, and in neuronal excitability and plasticity [ ]. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups [ ]: the pr... | [
"GO:0005249",
"GO:0006813",
"GO:0008076"
] | [
"voltage-gated potassium channel activity",
"potassium ion transport",
"voltage-gated potassium channel complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01510"
] | [
"KV13CHANNEL"
] | [
684
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1296072",
"R-MMU-1296072",
"R-RNO-1296072"
] | [
"REACTOME:R-HSA-1296072",
"REACTOME:R-MMU-1296072",
"REACTOME:R-RNO-1296072"
] | 3 | [
"7ej1",
"7ej2"
] | 2 | [
"PUB00001055",
"PUB00001622",
"PUB00002771",
"PUB00004011",
"PUB00004020",
"PUB00006577",
"PUB00007312",
"PUB00008322",
"PUB00009378",
"PUB00009391",
"PUB00036044"
] | [
"1772658",
"1879548",
"1373731",
"2448635",
"2451788",
"2555158",
"10798390",
"9305895",
"11178249",
"10712896",
"11343973"
] | [
"The molecular biology of K+ channels.",
"Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.",
"Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.",
"Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso... | [
1991,
1991,
1992,
1988,
1988,
1989,
2000,
1997,
2000,
2000,
2000
] | 11 | [
"IPR003972"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
684
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
1,
2
] | 4 | true | Family | Potassium channel, voltage dependent, Kv1.3 | Potassium channel, voltage dependent, Kv1.3 | K_chnl_volt-dep_Kv1.3 | 9 |
IPR004052 | 4,052 | Potassium channel, voltage dependent, Kv1.5 | K_chnl_volt-dep_Kv1.5 | Family | 537 | false | false | Potassium channels are the most diverse group of the ion channel family [ , ]. They are important in shaping the action potential, and in neuronal excitability and plasticity [ ]. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups [ ]: the pr... | [
"GO:0005249",
"GO:0006813",
"GO:0008076"
] | [
"voltage-gated potassium channel activity",
"potassium ion transport",
"voltage-gated potassium channel complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01512"
] | [
"KV15CHANNEL"
] | [
537
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1296072",
"R-HSA-5576890",
"R-MMU-1296072",
"R-MMU-5576890",
"R-RNO-1296072",
"R-RNO-5576890"
] | [
"REACTOME:R-HSA-1296072",
"REACTOME:R-HSA-5576890",
"REACTOME:R-MMU-1296072",
"REACTOME:R-MMU-5576890",
"REACTOME:R-RNO-1296072",
"REACTOME:R-RNO-5576890"
] | 6 | [] | 0 | [
"PUB00001055",
"PUB00001622",
"PUB00002771",
"PUB00004011",
"PUB00004020",
"PUB00006577",
"PUB00007312",
"PUB00007314",
"PUB00007315",
"PUB00007316",
"PUB00008322",
"PUB00009378",
"PUB00009391",
"PUB00036044"
] | [
"1772658",
"1879548",
"1373731",
"2448635",
"2451788",
"2555158",
"10798390",
"9118489",
"7615797",
"11163793",
"9305895",
"11178249",
"10712896",
"11343973"
] | [
"The molecular biology of K+ channels.",
"Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.",
"Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.",
"Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso... | [
1991,
1991,
1992,
1988,
1988,
1989,
2000,
1997,
1995,
2001,
1997,
2000,
2000,
2000
] | 14 | [
"IPR003972"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
537
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
2
] | 3 | true | Family | Potassium channel, voltage dependent, Kv1.5 | Potassium channel, voltage dependent, Kv1.5 | K_chnl_volt-dep_Kv1.5 | 1 |
IPR004053 | 4,053 | Potassium voltage-gated channel subfamily A member 6 | KCNA6 | Family | 389 | false | false | Potassium channels are the most diverse group of the ion channel family [ , ]. They are important in shaping the action potential, and in neuronal excitability and plasticity [ ]. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups [ ]: the pr... | [
"GO:0005249",
"GO:0006813",
"GO:0008076"
] | [
"voltage-gated potassium channel activity",
"potassium ion transport",
"voltage-gated potassium channel complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01513"
] | [
"KV16CHANNEL"
] | [
389
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1296072",
"R-MMU-1296072",
"R-RNO-1296072"
] | [
"REACTOME:R-HSA-1296072",
"REACTOME:R-MMU-1296072",
"REACTOME:R-RNO-1296072"
] | 3 | [] | 0 | [
"PUB00001055",
"PUB00001622",
"PUB00002771",
"PUB00004011",
"PUB00004020",
"PUB00006577",
"PUB00007312",
"PUB00008322",
"PUB00009378",
"PUB00009391",
"PUB00036044"
] | [
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"10798390",
"9305895",
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] | [
"The molecular biology of K+ channels.",
"Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.",
"Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.",
"Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso... | [
1991,
1991,
1992,
1988,
1988,
1989,
2000,
1997,
2000,
2000,
2000
] | 11 | [
"IPR003972"
] | [] | 1 | 0 | 1 | [
"Amniota"
] | [
389
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
4
] | 3 | true | Family | Potassium voltage-gated channel subfamily A member 6 | Potassium voltage-gated channel subfamily A member 6 | KCNA6 | 9 |
IPR004054 | 4,054 | Potassium channel, voltage dependent, Kv4.1 | K_chnl_volt-dep_Kv4.1 | Family | 369 | false | false | The Kv family can be divided into several subfamilies on the basis of sequence similarity and function. Four of these subfamilies, Kv1 (Shaker), Kv2 (Shab), Kv3 (Shaw) and Kv4 (Shal), consist of pore-forming alpha subunits that associate with different types of beta subunit. Each alpha subunit comprises six hydrophobic... | [
"GO:0005249",
"GO:0006813",
"GO:0008076"
] | [
"voltage-gated potassium channel activity",
"potassium ion transport",
"voltage-gated potassium channel complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01516"
] | [
"KV41CHANNEL"
] | [
369
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-1296072",
"R-BTA-5576894",
"R-HSA-1296072",
"R-HSA-5576894",
"R-MMU-1296072",
"R-MMU-5576894"
] | [
"REACTOME:R-BTA-1296072",
"REACTOME:R-BTA-5576894",
"REACTOME:R-HSA-1296072",
"REACTOME:R-HSA-5576894",
"REACTOME:R-MMU-1296072",
"REACTOME:R-MMU-5576894"
] | 6 | [] | 0 | [
"PUB00001055",
"PUB00001622",
"PUB00002771",
"PUB00004011",
"PUB00004020",
"PUB00006577",
"PUB00008322",
"PUB00009378",
"PUB00009391",
"PUB00036046"
] | [
"1772658",
"1879548",
"1373731",
"2448635",
"2451788",
"2555158",
"9305895",
"11178249",
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"15269337"
] | [
"The molecular biology of K+ channels.",
"Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.",
"Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.",
"Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso... | [
1991,
1991,
1992,
1988,
1988,
1989,
1997,
2000,
2000,
2004
] | 10 | [
"IPR003975"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
369
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
2,
2,
2
] | 4 | true | Family | Potassium channel, voltage dependent, Kv4.1 | Potassium channel, voltage dependent, Kv4.1 | K_chnl_volt-dep_Kv4.1 | 9 |
IPR004055 | 4,055 | Potassium channel, voltage dependent, Kv4.2 | K_chnl_volt-dep_Kv4.2 | Family | 696 | false | false | The Kv family can be divided into several subfamilies on the basis of sequence similarity and function. Four of these subfamilies, Kv1 (Shaker), Kv2 (Shab), Kv3 (Shaw) and Kv4 (Shal), consist of pore-forming alpha subunits that associate with different types of beta subunit. Each alpha subunit comprises six hydrophobic... | [
"GO:0005249",
"GO:0006813",
"GO:0008076"
] | [
"voltage-gated potassium channel activity",
"potassium ion transport",
"voltage-gated potassium channel complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01517"
] | [
"KV42CHANNEL"
] | [
696
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1296072",
"R-HSA-5576894",
"R-MMU-1296072",
"R-MMU-5576894",
"R-RNO-1296072",
"R-RNO-5576894"
] | [
"REACTOME:R-HSA-1296072",
"REACTOME:R-HSA-5576894",
"REACTOME:R-MMU-1296072",
"REACTOME:R-MMU-5576894",
"REACTOME:R-RNO-1296072",
"REACTOME:R-RNO-5576894"
] | 6 | [
"7e83",
"7e84",
"7e8e",
"7e8h",
"7f0j",
"7f3f",
"7uk5",
"7ukc",
"7ukd",
"7uke",
"7ukf",
"7ukg",
"7ukh"
] | 13 | [
"PUB00001055",
"PUB00001622",
"PUB00002771",
"PUB00004011",
"PUB00004020",
"PUB00006577",
"PUB00007317",
"PUB00007318",
"PUB00008322",
"PUB00009378",
"PUB00009391",
"PUB00036046",
"PUB00154491"
] | [
"1772658",
"1879548",
"1373731",
"2448635",
"2451788",
"2555158",
"10632587",
"11080179",
"9305895",
"11178249",
"10712896",
"15269337",
"34552243"
] | [
"The molecular biology of K+ channels.",
"Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.",
"Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.",
"Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso... | [
1991,
1991,
1992,
1988,
1988,
1989,
2000,
2000,
1997,
2000,
2000,
2004,
2021
] | 13 | [
"IPR003975"
] | [] | 1 | 0 | 1 | [
"Vertebrata"
] | [
696
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
4,
1,
3
] | 4 | true | Family | Potassium channel, voltage dependent, Kv4.2 | Potassium channel, voltage dependent, Kv4.2 | K_chnl_volt-dep_Kv4.2 | 7 |
IPR004056 | 4,056 | Potassium channel, voltage dependent, Kv4.3 | K_chnl_volt-dep_Kv4.3 | Family | 1,271 | false | false | The Kv family can be divided into several subfamilies on the basis of sequence similarity and function. Four of these subfamilies, Kv1 (Shaker), Kv2 (Shab), Kv3 (Shaw) and Kv4 (Shal), consist of pore-forming alpha subunits that associate with different types of beta subunit. Each alpha subunit comprises six hydrophobic... | [
"GO:0005249",
"GO:0006813",
"GO:0008076"
] | [
"voltage-gated potassium channel activity",
"potassium ion transport",
"voltage-gated potassium channel complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01518"
] | [
"KV43CHANNEL"
] | [
1271
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1296072",
"R-HSA-5576894",
"R-MMU-1296072",
"R-MMU-5576894",
"R-RNO-1296072",
"R-RNO-5576894"
] | [
"REACTOME:R-HSA-1296072",
"REACTOME:R-HSA-5576894",
"REACTOME:R-MMU-1296072",
"REACTOME:R-MMU-5576894",
"REACTOME:R-RNO-1296072",
"REACTOME:R-RNO-5576894"
] | 6 | [
"7w3y",
"7w6n",
"7w6s",
"7w6t"
] | 4 | [
"PUB00001055",
"PUB00001622",
"PUB00002771",
"PUB00004011",
"PUB00004020",
"PUB00006577",
"PUB00007319",
"PUB00007320",
"PUB00008322",
"PUB00009378",
"PUB00009391",
"PUB00036046",
"PUB00042076",
"PUB00154492"
] | [
"1772658",
"1879548",
"1373731",
"2448635",
"2451788",
"2555158",
"10200233",
"11087728",
"9305895",
"11178249",
"10712896",
"15269337",
"17187064",
"34997220"
] | [
"The molecular biology of K+ channels.",
"Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.",
"Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.",
"Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso... | [
1991,
1991,
1992,
1988,
1988,
1989,
1999,
2001,
1997,
2000,
2000,
2004,
2007,
2022
] | 14 | [
"IPR003975"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
1271
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
2,
3,
6
] | 4 | true | Family | Potassium channel, voltage dependent, Kv4.3 | Potassium channel, voltage dependent, Kv4.3 | K_chnl_volt-dep_Kv4.3 | 3 |
IPR004057 | 4,057 | Epsilon tubulin | Epsilon_tubulin | Family | 2,370 | false | false | Microtubules are polymers of tubulin, a dimer of two 55kDa subunits, designated alpha and beta [ , ]. Within the microtubule lattice, α-β heterodimers associate in a head-to-tail fashion, giving rise to microtubule polarity. Fluorescent labelling studies have suggested that tubulin is oriented in microtubules with beta... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR01519"
] | [
"EPSLNTUBULIN"
] | [
2370
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00000039",
"PUB00000721",
"PUB00000978",
"PUB00002443",
"PUB00006112",
"PUB00007321",
"PUB00007322",
"PUB00063568",
"PUB00072958"
] | [
"3896122",
"8274140",
"2194680",
"3680207",
"8102497",
"10620804",
"10753756",
"12510196",
"23704354"
] | [
"Molecular biology and genetics of tubulin.",
"Gamma-tubulin: the hub of cellular microtubule assemblies.",
"Diversity among tubulin subunits: toward what functional end?",
"Tubulin sequence region beta 155-174 is involved in binding exchangeable guanosine triphosphate.",
"Localization of an exchangeable GT... | [
1985,
1993,
1990,
1987,
1993,
2000,
2000,
2003,
2013
] | 9 | [
"IPR000217"
] | [] | 1 | 0 | 1 | [
"Eukaryota",
"Pseudomonadati"
] | [
2360,
10
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
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1,
5,
2,
6,
1
] | 5 | true | Family | Epsilon tubulin | Epsilon tubulin | Epsilon_tubulin | 5 |
IPR004058 | 4,058 | Zeta tubulin | Zeta_tubulin | Family | 44 | false | false | Microtubules are polymers of tubulin, a dimer of two 55kDa subunits, designated alpha and beta [ , ]. Within the microtubule lattice, α-β heterodimers associate in a head-to-tail fashion, giving rise to microtubule polarity. Fluorescent labelling studies have suggested that tubulin is oriented in microtubules with beta... | [] | [] | [] | 0 | [
"PRINTS"
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"ZETATUBULIN"
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44
] | 1 | [] | [] | [] | 0 | [] | 0 | [
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1985,
1993,
1990,
1987,
1993,
2000,
2001,
2015,
2019
] | 9 | [
"IPR000217"
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44
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IPR004059 | 4,059 | Orexin/Hypocretin receptor type 1 | OX1R | Family | 179 | false | false | The neuropeptide hormone orexin stimulates appetite and food consumption [ ], and is found in the hypothalamus, which has been shown to be the 'feeding centre' and plays a central role in the integrated control of feeding and energy homeostasis [ ]. It also has a prominent role in promoting wakefulness [ , , ]. The ore... | [
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"cellular_component"
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"PRINTS"
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"PR01521"
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"OREXIN1R"
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179
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"Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary ... | [
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1998,
1999,
1999,
2000,
1999,
2006,
2011,
2010,
2002,
2000,
2001,
2006,
2016
] | 14 | [
"IPR000204"
] | [] | 1 | 0 | 1 | [
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179
] | 1 | [
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2,
2
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IPR004060 | 4,060 | Orexin receptor 2 | Orexin_rcpt_2 | Family | 598 | false | false | The neuropeptide hormone orexin stimulates appetite and food consumption [ ], and is found in the hypothalamus, which has been shown to be the 'feeding centre' and plays a central role in the integrated control of feeding and energy homeostasis [ ]. It also has a prominent role in promoting wakefulness [ , , ]. The ore... | [
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598,
469
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"REACTOME:R-RNO-416476",
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1998,
1999,
1999,
2000,
1999,
2006,
2011,
2002,
1998,
2001,
2001,
2003
] | 13 | [
"IPR000204"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
598
] | 1 | [
"Danio rerio",
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1,
3,
3,
3
] | 4 | true | Family | Orexin receptor 2 | Orexin receptor 2 | Orexin_rcpt_2 | 3 |
IPR004061 | 4,061 | Sphingosine 1-phosphate receptor | S1P_rcpt | Family | 3,968 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0038036",
"GO:0007186",
"GO:0016020"
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"sphingosine-1-phosphate receptor activity",
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"PRINTS"
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"PR01523"
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"S1PRECEPTOR"
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3968
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1990,
1988,
1993,
1994,
2001,
1999,
2000,
2003,
1994,
2005,
2009,
2006,
2013
] | 13 | [
"IPR000276"
] | [
"IPR000987",
"IPR004062",
"IPR004063",
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3967,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
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12,
9,
9,
13
] | 4 | true | Family | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor | S1P_rcpt | 1 |
IPR004062 | 4,062 | EDG-3 sphingosine 1-phosphate receptor | EDG3_rcpt | Family | 782 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0038036",
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"PRINTS"
] | [
"PR01524"
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"EDG3RECEPTOR"
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782
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] | 7 | [
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1988,
1993,
1994,
2001,
1999,
2000,
1999,
2003,
1994,
2005,
2009,
2006,
2013
] | 14 | [
"IPR004061"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
782
] | 1 | [
"Danio rerio",
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1,
1,
1,
3
] | 4 | true | Family | EDG-3 sphingosine 1-phosphate receptor | EDG-3 sphingosine 1-phosphate receptor | EDG3_rcpt | 4 |
IPR004063 | 4,063 | EDG-5 sphingosine 1-phosphate receptor | EDG5_rcpt | Family | 478 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
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] | 3 | [
"PRINTS"
] | [
"PR01525"
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478
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1988,
1993,
1994,
2001,
1999,
2000,
1999,
2000,
2003,
1994,
2005,
2009,
2006,
2013
] | 15 | [
"IPR004061"
] | [] | 1 | 0 | 1 | [
"Euteleostomi",
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] | [
477,
1
] | 2 | [
"Homo sapiens",
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] | [
1,
2,
4
] | 3 | true | Family | EDG-5 sphingosine 1-phosphate receptor | EDG-5 sphingosine 1-phosphate receptor | EDG5_rcpt | 6 |
IPR004064 | 4,064 | EDG-6 sphingosine 1-phosphate receptor | EDG6_rcpt | Family | 486 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
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486
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1988,
1993,
1994,
2001,
1999,
2000,
1999,
2003,
1994,
2005,
2009,
2006,
2013
] | 14 | [
"IPR004061"
] | [] | 1 | 0 | 1 | [
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] | [
486
] | 1 | [
"Homo sapiens",
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"Rattus norvegicus"
] | [
1,
1,
2
] | 3 | true | Family | EDG-6 sphingosine 1-phosphate receptor | EDG-6 sphingosine 1-phosphate receptor | EDG6_rcpt | 4 |
IPR004065 | 4,065 | Lysophosphatidic acid receptor | LPA_rcpt | Family | 2,669 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0070915",
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"GO:0016020"
] | [
"lysophosphatidic acid receptor activity",
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] | [
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"PRINTS"
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"PR01527"
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2669
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"REACTOME:R-RNO-418594",
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] | 9 | [
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"7yu8",
"9izf",
"9izg",
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"9j5v"
] | 16 | [
"PUB00000131",
"PUB00002477",
"PUB00004960",
"PUB00004961",
"PUB00007103",
"PUB00007104",
"PUB00007190",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816"
] | [
"2111655",
"2830256",
"8386361",
"8170923",
"11264467",
"10603487",
"11093753",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293"
] | [
"G proteins in signal transduction.",
"G protein involvement in receptor-effector coupling.",
"Design of a discriminating fingerprint for G-protein-coupled receptors.",
"Fingerprinting G-protein-coupled receptors.",
"Lysophospholipid receptors.",
"Life on the edg.",
"Lysophosphatidic acid receptors.",
... | [
1990,
1988,
1993,
1994,
2001,
1999,
2000,
2003,
1994,
2005,
2009,
2006,
2013
] | 13 | [
"IPR000276"
] | [
"IPR002277",
"IPR004066",
"IPR005385"
] | 1 | 3 | 0 | [
"Vertebrata"
] | [
2669
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
11,
10,
6,
7
] | 4 | true | Family | Lysophosphatidic acid receptor | Lysophosphatidic acid receptor | LPA_rcpt | 4 |
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