LiteFold/InterPro · Datasets at Hugging Face

IPR003807

3,807

Domain of unknown function DUF202

DUF202

Domain

22,807

false

This entry describes a domain of unknown function found in bacterial inner membrane proteins and yeast vacuolar transporter chaperones.

[]

0

[ "PFAM" ]

[ "PF02656" ]

[ "DUF202" ]

[ 22807 ]

1

[]

0

[ "7ytj", "8i6v" ]

2

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 81, 12039, 10613, 2, 72 ]

5

[ "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 6, 4, 3 ]

4

true

Domain

Domain of unknown function DUF202

DUF202

3

IPR003808

3,808

Fe-S metabolism associated domain, SufE-like

Fe-S_metab-assoc_dom

Domain

15,680

false

This entry represents the core domain of SufE and related proteins. This domain of SufE shows strong structural similarity to IscU, and the sulfur-acceptor site in SufE coincides with the location of the cysteine residues mediating Fe-S cluster assembly in IscU. Thus, a conserved core structure is implicated in mediati...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF02657", "PTHR43597" ]

[ "SufE", "" ]

[ 15666, 14015 ]

2

[ "GP" ]

[ "GenProp0137" ]

[ "GP:GenProp0137" ]

1

[ "1mzg", "1ni7", "1wlo", "3g0m", "4lw4", "5eep", "5ft8", "5nq6", "8vbs" ]

9

[ "PUB00028992" ]

[ "15522304" ]

[ "The SufE sulfur-acceptor protein contains a conserved core structure that mediates interdomain interactions in a variety of redox protein complexes." ]

[ 2004 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "metagenomes" ]

[ 13425, 2058, 26, 171 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 10, 2, 8, 9 ]

4

true

Domain

Fe-S metabolism associated domain, SufE-like

Fe-S_metab-assoc_dom

1

IPR003810

3,810

Putative manganese efflux pump

Mntp/YtaF

Family

10,891

false

MntP is a family of bacterial proteins with a signal peptide and four transmembrane domains. It is a putative manganese efflux pump, since deletion of the gene leads to profound manganese sensitivity and elevated intracellular manganese levels in bacteria. Manganese is a highly important trace nutrient for organisms fr...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF02659", "PTHR35529" ]

[ "Mntp", "" ]

[ 10735, 10775 ]

2

[]

0

[]

0

[ "PUB00064727" ]

[ "21908668" ]

[ "The Escherichia coli MntR miniregulon includes genes encoding a small protein and an efflux pump required for manganese homeostasis." ]

[ 2011 ]

1

[]

[ "IPR014205", "IPR022929" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "Myoviridae sp. ctcaJ26", "unclassified sequences" ]

[ 161, 10601, 19, 1, 109 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Putative manganese efflux pump

Mntp/YtaF

9

IPR003812

3,812

Fido domain

Fido

Domain

54,432

false

This globular domain is named fido after the Fic and Doc proteins where it is found. It is approximately 125 to 150 residues long, and is present in proteins from all kingdoms of life [ , , , ], including: Fic (filamentation induced by cAMP) from diverse bacteria. It contains a longer insert in the fido domain. Doc (de...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF02661", "PS51459" ]

[ "Fic", "FIDO" ]

[ 50645, 53999 ]

2

[ "EC", "GP" ]

[ "2.7.7.108", "GenProp0321" ]

[ "EC:2.7.7.108", "GP:GenProp0321" ]

2

[ "2f6s", "2g03", "2jk8", "2vy3", "2vza", "3cuc", "3dd7", "3dd9", "3eqx", "3k33", "3kh2", "3let", "3n3u", "3s6a", "3se5", "3shg", "3sn9", "3zc7", "3zcb", "3zcn", "3zec", "3zlm", "4bep", "4ber", "4bes", "4itr", "4lu4", "4m16", "4n67", "4nps", "4py3", "4rgl"...

77

[ "PUB00015218", "PUB00051349", "PUB00051774", "PUB00057404" ]

[ "14659018", "18757857", "19127588", "19503829" ]

[ "New connections in the prokaryotic toxin-antitoxin network: relationship with the eukaryotic nonsense-mediated RNA decay system.", "Doc of prophage P1 is inhibited by its antitoxin partner Phd through fold complementation.", "Crystal structure of the Fic (Filamentation induced by cAMP) family protein SO4266 (g...

[ 2003, 2008, 2009, 2009 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Sym plasmid", "Viruses", "unclassified sequences" ]

[ 929, 47029, 5516, 1, 53, 904 ]

6

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 1, 1, 1, 1, 4 ]

7

true

Domain

Fido domain

Fido

3

IPR003813

3,813

F420-non-reducing hydrogenase iron-sulfur subunit D

MvhD/FlpD

Domain

3,197

false

This entry represents the F420-non-reducing hydrogenase iron-sulfur subunit D from Archaeoglobus profundus, MvhD , which is part of a complex that provides reducing equivalents for heterodisulfide reductase [ ], and from Methanobacterium thermoautotrophicum, known as FlpD [ ]. No specific functions have been assigned t...

[]

0

[ "PFAM" ]

[ "PF02662" ]

[ "FlpD" ]

[ 3197 ]

1

[ "EC" ]

[ "1.12.99.-" ]

[ "EC:1.12.99.-" ]

1

[ "5odc", "5odh", "5odi", "5odq", "5odr", "7bkb", "7bkc", "7bkd", "7bke", "8rvu", "8rvv", "8rvy" ]

12

[ "PUB00008258", "PUB00088715", "PUB00088716" ]

[ "7730278", "15009189", "19968794" ]

[ "Organization and growth phase-dependent transcription of methane genes in two regions of the Methanobacterium thermoautotrophicum genome.", "Two distinct heterodisulfide reductase-like enzymes in the sulfate-reducing archaeon Archaeoglobus profundus.", "Methanogenesis by Methanosarcina acetivorans involves two...

[ 1995, 2004, 2010 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Protostomia", "unclassified sequences" ]

[ 649, 2223, 3, 322 ]

4

[]

0

true

Domain

F420-non-reducing hydrogenase iron-sulfur subunit D

MvhD/FlpD

7

IPR003814

3,814

Formylmethanofuran dehydrogenase, subunit E domain

FmdEsu_dom

Domain

2,276

false

This entry represents a domain found in subunit E of formylmethanofuran dehydrogenase (FmdE). It appears to be related to the Tubulin/FtsZ 2-layer sandwich domain. Formylmethanofuran dehydrogenases ( ), found in methanogenic archaea, are molybdenum or tungsten iron-sulphur proteins containing a pterin dinucleotide cofa...

[]

0

[ "PFAM" ]

[ "PF02663" ]

[ "FmdE" ]

[ 2276 ]

1

[]

0

[ "2glz", "2gvi", "3d00" ]

3

[ "PUB00000170", "PUB00015859" ]

[ "9818358", "8575452" ]

[ "The formylmethanofuran dehydrogenase isoenzymes in Methanobacterium wolfei and Methanobacterium thermoautotrophicum: induction of the molybdenum isoenzyme by molybdate and constitutive synthesis of the tungsten isoenzyme.", "The tungsten formylmethanofuran dehydrogenase from Methanobacterium thermoautotrophicum ...

[ 1998, 1995 ]

2

[]

0

null

[ "Aduncisulcus paluster", "Archaea", "Bacteria", "unclassified sequences" ]

[ 1, 696, 1492, 87 ]

4

[]

0

true

Domain

Formylmethanofuran dehydrogenase, subunit E domain

FmdEsu_dom

2

IPR003815

3,815

S-ribosylhomocysteinase (LuxS)

S-ribosylhomocysteinase

Family

7,909

false

In bacteria, the regulation of gene expression in response to changes in cell density is called quorum sensing. Quorum-sensing bacteria produce, release, and respond to hormone-like molecules (autoinducers) that accumulate in the external environment as the cell population grows. For example, enteric bacteria use quoru...

[ "GO:0005506", "GO:0043768", "GO:0009372" ]

[ "iron ion binding", "S-ribosylhomocysteine lyase activity", "quorum sensing" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "HAMAP", "PFAM", "PIRSF", "PRINTS", "PANTHER" ]

[ "MF_00091", "PF02664", "PIRSF006160", "PR01487", "PTHR35799" ]

[ "LuxS", "LuxS", "AI2", "LUXSPROTEIN", "" ]

[ 6904, 7909, 6817, 7824, 7887 ]

5

[ "EC", "GP", "METACYC", "METACYC", "METACYC" ]

[ "4.4.1.21", "GenProp0757", "PWY-6151", "PWY-6153", "PWY-6154" ]

[ "EC:4.4.1.21", "GP:GenProp0757", "METACYC:PWY-6151", "METACYC:PWY-6153", "METACYC:PWY-6154" ]

5

[ "1ie0", "1inn", "1j6v", "1j6w", "1j6x", "1j98", "1joe", "1jqw", "1jvi", "1vgx", "1vh2", "1vje", "1ycl", "2fqo", "2fqt", "4xch", "5e68", "5v2w" ]

18

[ "PUB00019815", "PUB00032627", "PUB00035644", "PUB00035645" ]

[ "15287744", "15751951", "17133078", "16923076" ]

[ "Catalytic mechanism of S-ribosylhomocysteinase (LuxS): stereochemical course and kinetic isotope effect of proton transfer reactions.", "Crystal structure of S-ribosylhomocysteinase (LuxS) in complex with a catalytic 2-ketone intermediate.", "Quorum sensing by enteric pathogens.", "Isolation and functional a...

[ 2004, 2005, 2007, 2006 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Siphoviridae sp. ctaLC6", "unclassified sequences" ]

[ 7837, 14, 1, 57 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

S-ribosylhomocysteinase (LuxS)

S-ribosylhomocysteinase

1

IPR003816

3,816

Nitrate reductase, gamma subunit

Nitrate_red_gam

Family

7,306

false

The nitrate reductase enzyme ( ) is composed of three subunits; an alpha, a beta and two gamma. It is the second nitrate reductase enzyme which it can substitute for the NRA enzyme in Escherichia coli allowing it to use nitrate as an electron acceptor during anoerobic respiration [ ]. Nitrate reductase gamma subunit re...

[ "GO:0008940", "GO:0009325" ]

[ "nitrate reductase activity", "nitrate reductase complex" ]

[ "molecular_function", "cellular_component" ]

2

[ "NCBIFAM" ]

[ "TIGR00351" ]

[ "narI" ]

[ 7306 ]

1

[ "EC", "GP", "GP", "GP", "GP", "GP", "GP", "METACYC" ]

[ "1.7.5.1", "GenProp0636", "GenProp1122", "GenProp1329", "GenProp1474", "GenProp1583", "GenProp1676", "PWY-6748" ]

[ "EC:1.7.5.1", "GP:GenProp0636", "GP:GenProp1122", "GP:GenProp1329", "GP:GenProp1474", "GP:GenProp1583", "GP:GenProp1676", "METACYC:PWY-6748" ]

8

[ "1q16", "1siw", "1y4z", "1y5i", "1y5l", "1y5n", "3egw", "3ir5", "3ir6", "3ir7" ]

10

[ "PUB00008245", "PUB00008262" ]

[ "9738886", "2233673" ]

[ "Identification and characterization of the Staphylococcus carnosus nitrate reductase operon.", "Nitrate reductases of Escherichia coli: sequence of the second nitrate reductase and comparison with that encoded by the narGHJI operon." ]

[ 1998, 1990 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 15, 7217, 4, 70 ]

4

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Nitrate reductase, gamma subunit

Nitrate_red_gam

8

IPR003817

3,817

Phosphatidylserine decarboxylase-related

PS_Dcarbxylase

Family

32,742

false

PSD plays a pivotal role in the synthesis of phospholipid by the mitochondria. The substrate phosphatidylserine is synthesised extramitochondrially and must be translocated to the mitochondria prior to decarboxylation [ ]. Phosphatidylserine decarboxylases is responsible for conversion of phosphatidylserine to phosphat...

[ "GO:0004609", "GO:0008654" ]

[ "phosphatidylserine decarboxylase activity", "phospholipid biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER" ]

[ "PF02666", "PTHR10067" ]

[ "PS_Dcarbxylase", "" ]

[ 32522, 22475 ]

2

[ "EC", "GP", "METACYC", "REACTOME" ]

[ "4.1.1.65", "GenProp1542", "PWY-5669", "R-HSA-1483213" ]

[ "EC:4.1.1.65", "GP:GenProp1542", "METACYC:PWY-5669", "REACTOME:R-HSA-1483213" ]

4

[ "6l06", "6l07", "7cnw", "7cnx", "7cny", "7cnz", "8x4q", "8x4s", "8zia", "9jer", "9jf5", "9jfn" ]

12

[ "PUB00008264", "PUB00008265", "PUB00086873" ]

[ "8407984", "7890740", "28763571" ]

[ "Phosphatidylserine decarboxylase from Saccharomyces cerevisiae. Isolation of mutants, cloning of the gene, and creation of a null allele.", "Phosphatidylserine decarboxylase 2 of Saccharomyces cerevisiae. Cloning and mapping of the gene, heterologous expression, and creation of the null allele.", "Enzymatic Sy...

[ 1993, 1995, 2017 ]

3

[]

[ "IPR033175", "IPR033177" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 438, 19844, 12061, 34, 365 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 17, 1, 7, 2, 2, 5, 13, 4, 4, 14, 2, 3, 11 ]

13

true

Family

Phosphatidylserine decarboxylase-related

PS_Dcarbxylase

1

IPR003820

3,820

Potassium-transporting ATPase C chain

KdpC

Family

12,674

false

Kdp is a high affinity ATP-driven K+ transport system in Escherichia coli. It is a membrane complex (KdpFABC) composed of four subunits, KdpA, KdpB, KdpC and KdpF, although KdpF is not present in some species [ ]. It maintains intracellular homeostasis, cell shape and turgor under potassium-limiting conditions. KdpA is...

[ "GO:0008556", "GO:0006813", "GO:0016020" ]

[ "P-type potassium transmembrane transporter activity", "potassium ion transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "PFAM", "PIRSF", "PANTHER", "NCBIFAM" ]

[ "MF_00276", "PF02669", "PIRSF001296", "PTHR30042", "TIGR00681" ]

[ "KdpC", "KdpC", "K_ATPase_KdpC", "", "kdpC" ]

[ 12164, 12674, 11441, 12597, 10312 ]

5

[ "GP" ]

[ "GenProp0172" ]

[ "GP:GenProp0172" ]

1

[ "5mrw", "6hra", "6hrb", "7bgy", "7bh1", "7bh2", "7lc3", "7lc6", "7nnl", "7nnp", "7zrd", "7zre", "7zrg", "7zrh", "7zri", "7zrj", "7zrk", "7zrl", "7zrm", "9oc4" ]

20

[ "PUB00008269", "PUB00099204" ]

[ "9858692", "28636601" ]

[ "Assembly of the Kdp complex, the multi-subunit K+-transport ATPase of Escherichia coli.", "Crystal structure of the potassium-importing KdpFABC membrane complex." ]

[ 1998, 2017 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 78, 12510, 11, 75 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Potassium-transporting ATPase C chain

KdpC

4

IPR003821

3,821

1-deoxy-D-xylulose 5-phosphate reductoisomerase

DXP_reductoisomerase

Family

23,686

false

1-deoxy-D-xylulose 5-phosphate reductoisomerase synthesises 2-C-methyl-D-erythritol 4-phosphate from 1-deoxy-D-xylulose 5-phosphate in a single step by intramolecular rearrangement and reduction and is responsible for terpenoid biosynthesis in some organisms [ , ]. In Arabidopsis thaliana 1-deoxy-D-xylulose 5-phosphate...

[ "GO:0030604", "GO:0046872", "GO:0008299" ]

[ "1-deoxy-D-xylulose-5-phosphate reductoisomerase activity", "metal ion binding", "isoprenoid biosynthetic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "HAMAP", "PIRSF", "PANTHER", "NCBIFAM" ]

[ "MF_00183", "PIRSF006205", "PTHR30525", "TIGR00243" ]

[ "DXP_reductoisom", "Dxp_reductismrs", "", "Dxr" ]

[ 22730, 22198, 23685, 22419 ]

4

[ "EC", "GP", "GP", "METACYC" ]

[ "1.1.1.267", "GenProp0048", "GenProp1295", "PWY-7560" ]

[ "EC:1.1.1.267", "GP:GenProp0048", "GP:GenProp1295", "METACYC:PWY-7560" ]

4

[ "1jvs", "1k5h", "1onn", "1ono", "1onp", "1q0h", "1q0l", "1q0q", "1r0k", "1r0l", "1t1r", "1t1s", "2c82", "2egh", "2jcv", "2jcx", "2jcy", "2jd0", "2jd1", "2jd2", "2y1c", "2y1d", "2y1e", "2y1f", "2y1g", "3a06", "3a14", "3anl", "3anm", "3ann", "3au8", "3au9"...

88

[ "PUB00020977", "PUB00099840", "PUB00099841" ]

[ "9707569", "24998420", "30278288" ]

[ "A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis.", "Mechanism and inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase.", "Structural characterization of 1-deoxy-D-xylul...

[ 1998, 2014, 2018 ]

3

[]

0

null

[ "Bacteria", "Candidatus Iainarchaeum sp.", "Eukaryota", "unclassified sequences" ]

[ 21499, 2, 1530, 655 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 6, 1, 1, 17 ]

4

true

Family

1-deoxy-D-xylulose 5-phosphate reductoisomerase

DXP_reductoisomerase

9

IPR003823

3,823

CP12 domain

CP12_dom

Domain

2,409

false

This entry represents an uncharacterised domain found in calvin cycle protein CP12 and other proteins. This domain is sometimes found in association cystathionine-beta-synthase domains. CP12 is a chloroplast protein that regulates the Calvin cycle responsible for CO2 assimilation [ ]. Oxidized CP12 forms a supramolecul...

[]

0

[ "SMART" ]

[ "SM01093" ]

[ "CP12" ]

[ 2409 ]

1

[]

0

[ "2lj9", "3qv1", "3rvd", "5nmu", "5npl", "5nvd", "6gfo", "6gfq", "6gg7", "6ghl", "6ghr", "6gve", "6kez" ]

13

[ "PUB00089425", "PUB00089426" ]

[ "12846565", "22988853" ]

[ "The small protein CP12: a protein linker for supramolecular complex assembly.", "An intrinsically disordered protein, CP12: jack of all trades and master of the Calvin cycle." ]

[ 2003, 2012 ]

2

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota" ]

[ 914, 86, 1409 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 10, 6, 5 ]

3

true

Domain

CP12 domain

CP12_dom

9

IPR003824

3,824

Undecaprenyl-diphosphatase UppP

UppP

Family

29,140

false

This is a family of small, highly hydrophobic proteins. Over-expression of this protein in Escherichia coli is associated with bacitracin resistance [ ], and the protein was originally proposed to be an undecaprenol kinase called bacA. BacA protein, however, does not show undecaprenol phosphokinase activity [ ]. It is ...

[ "GO:0050380", "GO:0016311", "GO:0016020" ]

[ "undecaprenyl-diphosphatase activity", "dephosphorylation", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "PFAM", "PANTHER", "NCBIFAM" ]

[ "MF_01006", "PF02673", "PTHR30622", "TIGR00753" ]

[ "Undec_diphosphatase", "BacA", "", "undec_PP_bacA" ]

[ 28035, 29140, 29055, 18694 ]

4

[ "EC", "GP", "GP", "METACYC" ]

[ "3.6.1.27", "GenProp0971", "GenProp1670", "PWY-5785" ]

[ "EC:3.6.1.27", "GP:GenProp0971", "GP:GenProp1670", "METACYC:PWY-5785" ]

4

[ "5oon", "6cb2", "6fmt", "6fmv", "6fmw" ]

5

[ "PUB00008274", "PUB00043016", "PUB00043299", "PUB00043300" ]

[ "8389741", "15138271", "15946938", "15778224" ]

[ "Amplification of the bacA gene confers bacitracin resistance to Escherichia coli.", "The bacA gene of Escherichia coli encodes an undecaprenyl pyrophosphate phosphatase activity.", "BcrC from Bacillus subtilis acts as an undecaprenyl pyrophosphate phosphatase in bacitracin resistance.", "Identification of mu...

[ 1993, 2004, 2005, 2005 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Myoviridae sp. ctVCj30", "unclassified sequences" ]

[ 459, 28005, 19, 1, 656 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Undecaprenyl-diphosphatase UppP

UppP

4

IPR003825

3,825

Colicin V production, CvpA

Colicin-V_CvpA

Family

21,512

false

Colicin V is a small extracellular protein toxin which kills sensitive cells by disrupting their membrane potential [ ]. Colicin V is produced from large low-copy plasmids and requires four plasmid genes for synthesis export and immunity [ 3034857). The cvaC gene is the structural gene for colicin V and cvaA and cvaB a...

[ "GO:0009403", "GO:0016020" ]

[ "toxin biosynthetic process", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF02674" ]

[ "Colicin_V" ]

[ 21512 ]

1

[]

0

[]

0

[ "PUB00008275", "PUB00054034", "PUB00054035" ]

[ "2542219", "6373733", "6271732" ]

[ "Characterization of a purF operon mutation which affects colicin V production.", "Colicin V-treated Escherichia coli does not generate membrane potential.", "Cloning of immunity and structural genes for colicin V." ]

[ 1989, 1984, 1981 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Myoviridae sp. ctWXg38", "unclassified sequences" ]

[ 21081, 14, 2, 1, 414 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Colicin V production, CvpA

Colicin-V_CvpA

1

IPR003826

3,826

S-adenosylmethionine decarboxylase family, prokaryotic

AdoMetDC_fam_prok

Family

10,971

false

Polyamines such as spermidine and spermine are essential for cellular growth under most conditions, being implicated in a large number of cellular processes including DNA, RNA and protein synthesis. S-adenosylmethionine decarboxylase (AdoMetDC) plays an essential regulatory role in the polyamine biosynthetic pathway by...

[ "GO:0004014", "GO:0008295" ]

[ "adenosylmethionine decarboxylase activity", "spermidine biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER" ]

[ "PF02675", "PTHR33866" ]

[ "AdoMet_dc", "" ]

[ 10951, 9844 ]

2

[ "EC", "GP", "GP", "GP", "METACYC" ]

[ "4.1.1.50", "GenProp0641", "GenProp1571", "GenProp1596", "PWY-6834" ]

[ "EC:4.1.1.50", "GP:GenProp0641", "GP:GenProp1571", "GP:GenProp1596", "METACYC:PWY-6834" ]

5

[ "1tlu", "1tmi", "1vr7", "2iii", "3iwb", "3iwc", "3iwd" ]

7

[ "PUB00019108", "PUB00019109", "PUB00035745", "PUB00035746", "PUB00064852" ]

[ "11526206", "10844697", "2197977", "10047786", "18650422" ]

[ "In vivo mechanism-based inactivation of S-adenosylmethionine decarboxylases from Escherichia coli, Salmonella typhimurium, and Saccharomyces cerevisiae.", "S-adenosylmethionine decarboxylase of Bacillus subtilis is closely related to archaebacterial counterparts.", "Pyruvoyl-dependent enzymes.", "S-adenosylm...

[ 2001, 2000, 1990, 1998, 2008 ]

5

[]

[ "IPR009165", "IPR017716" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 480, 9932, 234, 68, 257 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)" ]

[ 1, 1 ]

2

true

Family

S-adenosylmethionine decarboxylase family, prokaryotic

AdoMetDC_fam_prok

1

IPR003827

3,827

tRNA wybutosine-synthesizing protein

tRNA_yW-synthesising

Domain

3,795

false

The methyltransferase TYW3 (tRNA-yW- synthesising protein 3) has been identified in yeast to be involved in wybutosine (yW) biosynthesis [ ]. yW is a complexly modified guanosine residue that contains a tricyclic base and is found at the 3'-position adjacent the anticodon of phenylalanine tRNA. TYW3 is an N-4 methylase...

[]

0

[ "PFAM" ]

[ "PF02676" ]

[ "TYW3" ]

[ 3795 ]

1

[ "EC", "GP", "METACYC", "REACTOME" ]

[ "2.1.1.282", "GenProp1241", "PWY-7286", "R-HSA-6782861" ]

[ "EC:2.1.1.282", "GP:GenProp1241", "METACYC:PWY-7286", "REACTOME:R-HSA-6782861" ]

4

[ "1tlj", "2drv", "2dvk", "2it2", "2it3", "2qg3" ]

6

[ "PUB00044611" ]

[ "16642040" ]

[ "Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA." ]

[ 2006 ]

1

[]

0

null

[ "Archaea", "Bacteria candidate phyla", "Eukaryota", "ecological metagenomes" ]

[ 310, 2, 3477, 6 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (st...

[ 5, 2, 4, 4, 1, 1, 6, 1, 1, 6 ]

10

true

Domain

tRNA wybutosine-synthesizing protein

tRNA_yW-synthesising

5

IPR003828

3,828

Epoxyqueuosine reductase QueH

QueH

Family

5,612

false

QueH has been predicted to be an epoxyqueuosine reductase that catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) [ ].

[]

0

[ "HAMAP", "PFAM", "PANTHER" ]

[ "MF_02089", "PF02677", "PTHR36701" ]

[ "QueH", "QueH", "" ]

[ 5144, 5612, 5576 ]

3

[ "EC", "METACYC", "METACYC" ]

[ "1.17.99.6", "PWY-6700", "PWY-8106" ]

[ "EC:1.17.99.6", "METACYC:PWY-6700", "METACYC:PWY-8106" ]

3

[ "7lc5", "7lc7", "9d86", "9dco", "9deu" ]

5

[ "PUB00085190" ]

[ "28128549" ]

[ "Identification of a Novel Epoxyqueuosine Reductase Family by Comparative Genomics." ]

[ 2017 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "unclassified sequences" ]

[ 5405, 89, 6, 112 ]

4

[]

0

true

Family

Epoxyqueuosine reductase QueH

QueH

7

IPR003830

3,830

(2R)-phospho-3-sulpholactate synthase, ComA

ComA_synth

Family

3,181

false

Methanogenic archaea produce methane via the anaerobic reduction of acetate or single carbon compounds [ ]. Coenzyme M (CoM; 2-mercaptoethanesulphonic acid) serves as the terminal methyl carrier for this process. Previously thought to be unique to methanogenic archaea, CoM has also been found in methylotrophic bacteria...

[]

0

[ "PFAM" ]

[ "PF02679" ]

[ "ComA" ]

[ 3181 ]

1

[ "EC" ]

[ "4.4.1.19" ]

[ "EC:4.4.1.19" ]

1

[ "1qwg", "1u83", "9cm1" ]

3

[ "PUB00010729", "PUB00010730", "PUB00010731", "PUB00010732", "PUB00010733", "PUB00077547" ]

[ "12440773", "11830598", "11589710", "10850983", "10940029", "23439916" ]

[ "Redox-driven proton translocation in methanogenic Archaea.", "Identification of coenzyme M biosynthetic phosphosulfolactate synthase: a new family of sulfonate-biosynthesizing enzymes.", "Identification of coenzyme M biosynthetic 2-phosphosulfolactate phosphatase. A member of a new class of Mg(2+)-dependent ac...

[ 2002, 2002, 2001, 2000, 2000, 2013 ]

6

[]

[ "IPR022370" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 166, 1789, 1177, 49 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 3, 3 ]

3

true

Family

(2R)-phospho-3-sulpholactate synthase, ComA

ComA_synth

6

IPR003831

3,831

Protein of unknown function DUF211

DUF211

Family

631

false

This entry represents a group of prokaryotic proteins of unknown function that includes Uncharacterized protein MJ0319 from Methanocaldococcus jannaschii ( ).

[]

0

[ "PFAM", "PANTHER" ]

[ "PF02680", "PTHR42240" ]

[ "DUF211", "" ]

[ 631, 624 ]

2

[]

0

[ "2raq", "2x3d", "3bpd" ]

3

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Cyprideis torosa", "ecological metagenomes" ]

[ 483, 125, 1, 22 ]

4

[]

0

true

Family

Protein of unknown function DUF211

DUF211

4

IPR003833

3,833

Carboxyltransferase domain, subdomain C and D

CT_C_D

Domain

22,233

false

Urea carboxylase (UC) catalyses a two-step, ATP- and biotin-dependent carboxylation reaction of urea. It is composed of biotin carboxylase (BC), carboxyltransferase (CT), and biotin carboxyl carrier protein (BCCP) domains. The CT domain of UC consists of four subdomains, named A, B, C and D. This domain covers the C an...

[]

0

[ "PFAM", "SMART" ]

[ "PF02682", "SM00796" ]

[ "CT_C_D", "AHS1" ]

[ 22227, 22069 ]

2

[]

0

[ "2kwa", "2phc", "2zp2", "3mml", "3oep", "3opf", "3ore", "3va7", "5dud", "5i8i" ]

10

[ "PUB00064884", "PUB00076467", "PUB00076468", "PUB00076469", "PUB00088732" ]

[ "9334321", "20884691", "22869039", "22277658", "28830929" ]

[ "A novel histidine kinase inhibitor regulating development in Bacillus subtilis.", "Dur3 is the major urea transporter in Candida albicans and is co-regulated with the urea amidolyase Dur1,2.", "Structure and function of biotin-dependent carboxylases.", "Crystal structure of urea carboxylase provides insights...

[ 1997, 2011, 2013, 2012, 2017 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 82, 20354, 1589, 208 ]

4

[ "Escherichia coli (strain K12)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1 ]

2

true

Domain

Carboxyltransferase domain, subdomain C and D

CT_C_D

7

IPR003834

3,834

Cytochrome C biogenesis protein, transmembrane domain

Cyt_c_assmbl_TM_dom

Domain

34,460

false

This entry represents the transmembrane domain of Cytochrome C biogenesis proteins also known as disulphide interchange proteins, such as DsbD from E. coli and DipZ from Mycobacterium. These proteins posses a protein disulphide isomerase like domain that is not found within the aligned region of this family. DsbA and D...

[ "GO:0017004", "GO:0016020" ]

[ "cytochrome complex assembly", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF02683" ]

[ "DsbD_TM" ]

[ 34460 ]

1

[ "EC" ]

[ "1.8.1.8" ]

[ "EC:1.8.1.8" ]

1

[ "5vkv" ]

1

[ "PUB00008276", "PUB00008277" ]

[ "7628442", "7623667" ]

[ "Identification and characterization of a new disulfide isomerase-like protein (DsbD) in Escherichia coli.", "The biogenesis of c-type cytochromes in Escherichia coli requires a membrane-bound protein, DipZ, with a protein disulphide isomerase-like domain." ]

[ 1995, 1995 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctPAi1", "unclassified sequences" ]

[ 429, 32560, 864, 1, 606 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 6, 1, 4, 7 ]

4

true

Domain

Cytochrome C biogenesis protein, transmembrane domain

Cyt_c_assmbl_TM_dom

7

IPR003835

3,835

Glycosyl transferase, family 19

Glyco_trans_19

Family

16,187

false

The biosynthesis of disaccharides, oligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These enzymes catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. A classification of glycosyltransferas...

[ "GO:0008915", "GO:0009245" ]

[ "lipid-A-disaccharide synthase activity", "lipid A biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PFAM", "PANTHER", "NCBIFAM" ]

[ "MF_00392", "PF02684", "PTHR30372", "TIGR00215" ]

[ "LpxB", "LpxB", "", "lpxB" ]

[ 8065, 15702, 16079, 14303 ]

4

[ "CAZY", "EC", "GP", "GP", "METACYC", "METACYC", "METACYC" ]

[ "GT19", "2.4.1.182", "GenProp0204", "GenProp1290", "PWY-8073", "PWY-8245", "PWY-8283" ]

[ "CAZY:GT19", "EC:2.4.1.182", "GP:GenProp0204", "GP:GenProp1290", "METACYC:PWY-8073", "METACYC:PWY-8245", "METACYC:PWY-8283" ]

7

[ "5w8n", "5w8s", "5w8x", "7tgh", "8b6f", "8bqs", "8gym", "8gzu" ]

8

[ "PUB00009409" ]

[ "9334165" ]

[ "A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities." ]

[ 1997 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified Caudoviricetes", "unclassified sequences" ]

[ 14756, 1079, 2, 350 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 7, 1, 2, 8 ]

4

true

Family

Glycosyl transferase, family 19

Glyco_trans_19

2

IPR003836

3,836

Glucokinase

Family

10,979

false

Glucokinases ( ) are found in invertebrates and microorganisms and are highly specific for glucose. These enzymes phosphorylate glucose using ATP as a donor to give glucose-6-phosphate and ADP [ ].

[ "GO:0004340", "GO:0005524", "GO:0005536", "GO:0006096", "GO:0051156" ]

[ "glucokinase activity", "ATP binding", "D-glucose binding", "glycolytic process", "glucose 6-phosphate metabolic process" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "biological_process" ]

5

[ "HAMAP", "PFAM", "NCBIFAM", "CDD" ]

[ "MF_00524", "PF02685", "TIGR00749", "cd24008" ]

[ "Glucokinase", "Glucokinase", "glk", "ASKHA_NBD_GLK" ]

[ 7243, 10979, 7837, 10577 ]

4

[ "EC", "GP", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.7.1.2", "GenProp1394", "GenProp1412", "GenProp1564", "PWY-2722", "PWY-2723", "PWY-5514", "PWY-5661", "PWY-5941", "PWY-621", "PWY-7238", "PWY-7385" ]

[ "EC:2.7.1.2", "GP:GenProp1394", "GP:GenProp1412", "GP:GenProp1564", "METACYC:PWY-2722", "METACYC:PWY-2723", "METACYC:PWY-5514", "METACYC:PWY-5661", "METACYC:PWY-5941", "METACYC:PWY-621", "METACYC:PWY-7238", "METACYC:PWY-7385" ]

12

[ "1q18", "1sz2", "2q2r", "3vpz", "5brd", "5bre", "5brf", "5brh", "6da0", "6edi", "6vzz", "7s2h", "7s2n", "7s2p", "8dtc", "8stx", "9duc", "9dvz" ]

18

[ "PUB00000566", "PUB00003590", "PUB00008278", "PUB00030072", "PUB00048853", "PUB00158289", "PUB00158313", "PUB00158314", "PUB00158315", "PUB00158316" ]

[ "2199258", "7952186", "9023215", "15466045", "17761195", "20512568", "11250082", "26778112", "30783001", "30571993" ]

[ "Hexokinases and glucokinases.", "Evolutionary relationships between sugar kinases and transcriptional repressors in bacteria.", "Molecular characterization of glucokinase from Escherichia coli K-12.", "Crystal structures of Escherichia coli ATP-dependent glucokinase and its complex with glucose.", "The cry...

[ 1990, 1994, 1997, 2004, 2007, 2010, 2001, 2015, 2019, 2019 ]

10

[]

0

null

[ "Bacteria", "Eukaryota", "Methanomicrobia", "unclassified sequences" ]

[ 10165, 697, 6, 111 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Glucokinase

2

IPR003837

3,837

Glu-tRNAGln amidotransferase C subunit

GatC

Family

23,503

false

This entry includes the C subunit of the bacterial/archaeal aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferases (known as GatC) and eukaryotic Glu-tRNAGln amidotransferases. Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase ([ec:6.3.5.-]) allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the...

[ "GO:0006450" ]

[ "regulation of translational fidelity" ]

[ "biological_process" ]

1

[ "HAMAP", "PFAM", "PANTHER", "NCBIFAM" ]

[ "MF_00122", "PF02686", "PTHR15004", "TIGR00135" ]

[ "GatC", "GatC", "", "gatC" ]

[ 20985, 22601, 21174, 21445 ]

4

[ "EC", "GP", "GP", "GP", "GP", "METACYC", "METACYC", "METACYC" ]

[ "6.3.5.-", "GenProp0188", "GenProp0258", "GenProp1383", "GenProp1660", "PWY-5297", "PWY-7811", "PWY-8229" ]

[ "EC:6.3.5.-", "GP:GenProp0188", "GP:GenProp0258", "GP:GenProp1383", "GP:GenProp1660", "METACYC:PWY-5297", "METACYC:PWY-7811", "METACYC:PWY-8229" ]

8

[ "2df4", "2dqn", "2f2a", "2g5h", "2g5i", "3al0", "3h0l", "3h0m", "3h0r", "3ip4", "3kfu", "4wj3" ]

12

[ "PUB00007932" ]

[ "9342321" ]

[ "Glu-tRNAGln amidotransferase: a novel heterotrimeric enzyme required for correct decoding of glutamine codons during translation." ]

[ 1997 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 646, 19436, 2928, 493 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 3, 1, 3, 2, 4, 1, 1, 1, 5, 3 ]

10

true

Family

Glu-tRNAGln amidotransferase C subunit

GatC

7

IPR003838

3,838

ABC3 transporter permease, C-terminal

ABC3_permease_C

Domain

205,484

false

This domain is found in members of the ABC type 3 transporter family [ ]. Proteins containing this domain include: Cell division protein FtsX from Gram-negative and Gram-positive bacteria. It is a component of the septal ring [ ]. It may insert division proteins into the cytoplasmic membrane [ ]. Permease protein MacB ...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF02687" ]

[ "FtsX" ]

[ 205484 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-9638334", "R-HSA-9760173", "R-HSA-9913143" ]

[ "REACTOME:R-HSA-9638334", "REACTOME:R-HSA-9760173", "REACTOME:R-HSA-9913143" ]

3

[ "5gko", "5lil", "5lj6", "5lj7", "5nik", "5nil", "5ws4", "5xu1", "7arh", "7ari", "7arj", "7ark", "7arl", "7arm", "7mdx", "7mdy", "7tcg", "7tch", "7v8i", "7v8l", "7v8m", "7w78", "7w79", "7w7a", "7w7b", "7w7c", "7w7d", "8g3a", "8g3b", "8g3f", "8g3l", "8g4c"...

60

[ "PUB00054122", "PUB00062414", "PUB00062416", "PUB00071889", "PUB00072503", "PUB00072504", "PUB00072505", "PUB00072506", "PUB00096431" ]

[ "10986249", "12890034", "15870467", "18955484", "19376877", "12370001", "10783239", "16933993", "19806386" ]

[ "An operon for a putative ATP-binding cassette transport system involved in acetoin utilization of Bacillus subtilis.", "The BceRS two-component regulatory system induces expression of the bacitracin transporter, BceAB, in Bacillus subtilis.", "Cationic antimicrobial peptides elicit a complex stress response in...

[ 2000, 2003, 2005, 2009, 2009, 2002, 2000, 2006, 2009 ]

9

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified Caudoviricetes", "unclassified sequences" ]

[ 2758, 199484, 541, 5, 2696 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica" ]

[ 2, 6, 2 ]

3

true

Domain

ABC3 transporter permease, C-terminal

ABC3_permease_C

4

IPR003839

3,839

7TM GPCR, serpentine receptor class u (Sru)

7TM_GPCR_serpentine_rcpt_Sru

Family

615

false

G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10322", "PTHR46045" ]

[ "7TM_GPCR_Sru", "" ]

[ 615, 393 ]

2

[]

0

[]

0

[ "PUB00000924", "PUB00004961", "PUB00007387", "PUB00044128", "PUB00044129", "PUB00053635", "PUB00063577", "PUB00063578", "PUB00063579", "PUB00063580", "PUB00063816" ]

[ "7585938", "8170923", "10580986", "18050473", "15618405", "12679517", "8081729", "15914470", "18948278", "16753280", "23020293" ]

[ "Divergent seven transmembrane receptors are candidate chemosensory receptors in C. elegans.", "Fingerprinting G-protein-coupled receptors.", "Chemosensory signaling in C. elegans.", "The putative chemoreceptor families of C. elegans.", "Identification of a nematode chemosensory gene family.", "The G prot...

[ 1995, 1994, 1999, 2006, 2005, 2003, 1994, 2005, 2009, 2006, 2013 ]

11

[]

0

null

[ "Nitratireductor basaltis", "Rhabditida" ]

[ 1, 614 ]

2

[ "Caenorhabditis elegans" ]

[ 50 ]

1

true

Family

7TM GPCR, serpentine receptor class u (Sru)

7TM_GPCR_serpentine_rcpt_Sru

9

IPR003840

3,840

DNA replication helicase domain

DNA_helicase_dom

Domain

1,727

false

This entry represents a domain found in viral DNA replication helicases, bacterial ATP-dependent DNA helicase Pif1 and eukaryotic ATP-dependent DNA helicase PIF7.

[ "GO:0004386", "GO:0005524" ]

[ "helicase activity", "ATP binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM" ]

[ "PF02689" ]

[ "Herpes_Helicase" ]

[ 1727 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME" ]

[ "3.6.4.-", "PWY-7250", "R-HSA-9609690", "R-HSA-9610379" ]

[ "EC:3.6.4.-", "METACYC:PWY-7250", "REACTOME:R-HSA-9609690", "REACTOME:R-HSA-9610379" ]

4

[ "9ndt", "9ne0", "9nee", "9nel" ]

4

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Heunggongvirae", "ecological metagenomes" ]

[ 131, 496, 1091, 9 ]

4

[ "Homo sapiens", "Zea mays" ]

[ 1, 1 ]

2

true

Domain

DNA replication helicase domain

DNA_helicase_dom

6

IPR003841

3,841

Sodium-dependent phosphate transport protein

Na/Pi_transpt

Family

19,339

false

This family consists of sodium-dependent phosphate transport proteins of the solute carrier family SLC34A [ ]. It includes mammalian type II renal Na+/Pi-cotransporters and other proteins from lower eukaryotes and bacteria, some of which are also Na+/Pi-cotransporters. In kidneys these proteins may be involved in activ...

[ "GO:0005436", "GO:0044341", "GO:0016020" ]

[ "sodium:phosphate symporter activity", "sodium-dependent phosphate transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER", "NCBIFAM" ]

[ "PF02690", "PTHR10010", "TIGR01013" ]

[ "Na_Pi_cotrans", "", "2a58" ]

[ 19019, 19121, 5731 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-427589", "R-HSA-5619040", "R-HSA-5619045", "R-HSA-5619097", "R-HSA-5683826", "R-HSA-5687583", "R-MMU-427589", "R-MMU-5683826", "R-RNO-427589", "R-RNO-5683826" ]

[ "REACTOME:R-HSA-427589", "REACTOME:R-HSA-5619040", "REACTOME:R-HSA-5619045", "REACTOME:R-HSA-5619097", "REACTOME:R-HSA-5683826", "REACTOME:R-HSA-5687583", "REACTOME:R-MMU-427589", "REACTOME:R-MMU-5683826", "REACTOME:R-RNO-427589", "REACTOME:R-RNO-5683826" ]

10

[]

0

[ "PUB00008280", "PUB00055070" ]

[ "8327470", "12750889" ]

[ "Expression cloning of human and rat renal cortex Na/Pi cotransport.", "The sodium phosphate cotransporter family SLC34." ]

[ 1993, 2004 ]

2

[]

[ "IPR004633" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 96, 14440, 4583, 220 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 23, 1, 14, 8, 17 ]

6

true

Family

Sodium-dependent phosphate transport protein

Na/Pi_transpt

9

IPR003842

3,842

Vacuolating cytotoxin, beta-helical domain

VacA_beta-helix

Domain

1,859

false

This entry represents the N-terminal domain of Vacuolating cyotoxin proteins (VacA), which adopts a right-handed parallel β-helix fold [ , ]. VacA forms a hexamer that may correspond to the prepore-forming state, and this region may be responsible for the membrane insertion. Helicobacter pylori is a micro-aerophilic ba...

[ "GO:0005576" ]

[ "extracellular region" ]

[ "cellular_component" ]

1

[ "PFAM", "PRINTS" ]

[ "PF02691", "PR01656" ]

[ "VacA", "VACCYTOTOXIN" ]

[ 1613, 1299 ]

2

[]

0

[ "2qv3", "6nyf", "6nyg", "6nyj", "6nyl", "6nym", "6nyn", "6ody" ]

8

[ "PUB00007565", "PUB00049157", "PUB00162461" ]

[ "11160018", "17911250", "30894496" ]

[ "Amino-terminal hydrophobic region of Helicobacter pylori vacuolating cytotoxin (VacA) mediates transmembrane protein dimerization.", "Crystal structure of the Helicobacter pylori vacuolating toxin p55 domain.", "Cryo-EM structures of <i>Helicobacter pylori</i> vacuolating cytotoxin A oligomeric assemblies at n...

[ 2001, 2007, 2019 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "freshwater metagenome" ]

[ 1850, 8, 1 ]

3

[]

0

true

Domain

Vacuolating cytotoxin, beta-helical domain

VacA_beta-helix

6

IPR003844

3,844

Uncharacterised protein family UPF0060

UPF0060

Family

9,507

false

This entry describes a family of integral membrane proteins. Some members of this family have been proposed to function as a thallium-specific efflux pump [ ].

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "HAMAP", "NCBIFAM", "PFAM", "PANTHER" ]

[ "MF_00010", "NF002586", "PF02694", "PTHR36116" ]

[ "UPF0060", "PRK02237.1", "UPF0060", "" ]

[ 9004, 9057, 9507, 9383 ]

4

[]

0

[]

0

[ "PUB00093610" ]

[ "29769716" ]

[ "Mutant phenotypes for thousands of bacterial genes of unknown function." ]

[ 2018 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 85, 9225, 150, 2, 45 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family UPF0060

UPF0060

9

IPR003846

3,846

Protein adenylyltransferase SelO

SelO

Family

19,720

false

SelO and its homologues are widespread among most eukaryotic taxa, and are also common in many major bacterial taxa. SelO is a conserved pseudokinase that transfers AMP from ATP to Ser, Thr, and Tyr residues on protein substrates (AMPylation). It contains a protein kinase fold with ATP flipped in the active site [ ]. I...

[]

0

[ "HAMAP", "PFAM", "PANTHER" ]

[ "MF_00692", "PF02696", "PTHR32057" ]

[ "SelO", "SelO", "" ]

[ 16975, 19629, 16145 ]

3

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.7.7.-", "2.7.7.108", "PWY-6322", "PWY-6626", "PWY-6749", "PWY-6955", "PWY-6998", "PWY-7127", "PWY-7419", "PWY-7529", "PWY-7706", "PWY-7719", "PWY-7735", "PWY-7737", "PWY-7769", "PWY-7888", "PWY-7904", "PWY-8117", "PWY-8179" ]

[ "EC:2.7.7.-", "EC:2.7.7.108", "METACYC:PWY-6322", "METACYC:PWY-6626", "METACYC:PWY-6749", "METACYC:PWY-6955", "METACYC:PWY-6998", "METACYC:PWY-7127", "METACYC:PWY-7419", "METACYC:PWY-7529", "METACYC:PWY-7706", "METACYC:PWY-7719", "METACYC:PWY-7735", "METACYC:PWY-7737", "METACYC:PWY-7769"...

19

[ "6eac", "6iii", "6iny", "6k20", "6lna" ]

5

[ "PUB00092455", "PUB00092456" ]

[ "30270044", "24751718" ]

[ "Protein AMPylation by an Evolutionarily Conserved Pseudokinase.", "Characterization of mammalian selenoprotein o: a redox-active mitochondrial protein." ]

[ 2018, 2014 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 42, 13955, 5529, 5, 189 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)...

[ 7, 2, 1, 2, 4, 1, 3, 4, 1, 1, 10 ]

11

true

Family

Protein adenylyltransferase SelO

SelO

9

IPR003847

3,847

Putative antitoxin

Put_antitoxin

Family

1,087

false

Proteins in this family represent the antitoxin component of a toxin-antitoxin (TA) module, which includes VapB2, VapB3, VapB18, AF_1481, M1627_0365 and similar antitoxins. TA loci are thought to be mobile cassettes that move frequently within and between chromosomes and may function as stress-response elements benefic...

[]

0

[ "HAMAP", "PFAM" ]

[ "MF_00794", "PF02697" ]

[ "UPF0330", "VAPB_antitox" ]

[ 114, 1087 ]

2

[]

0

[]

0

[ "PUB00056596" ]

[ "15718296" ]

[ "Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes." ]

[ 2005 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "unclassified sequences" ]

[ 980, 52, 2, 53 ]

4

[]

0

true

Family

Putative antitoxin

Put_antitoxin

9

IPR003848

3,848

Domain of unknown function DUF218

DUF218

Domain

39,006

false

This domain contains several highly conserved charged amino acids, suggesting this may be an enzymatic domain. It is found in Escherichia coli YdcF, which has been shown to bind S-adenosyl-L-methionine (AdoMet), but whose biochemical function has not been identified [ ]. It is also found in Escherichia coli SanA and Sa...

[]

0

[ "PFAM", "CDD" ]

[ "PF02698", "cd06259" ]

[ "DUF218", "YdcF-like" ]

[ 38791, 38242 ]

2

[]

0

[ "3ca8" ]

1

[ "PUB00019464", "PUB00019465", "PUB00050945", "PUB00104618" ]

[ "8550448", "9738879", "18393394", "24391520" ]

[ "Amplification of a novel gene, sanA, abolishes a vancomycin-sensitive defect in Escherichia coli.", "The sfiX, rfe and metN genes of Salmonella typhimurium and their involvement in the His(c) pleiotropic response.", "The Escherichia coli YdcF binds S-adenosyl-L-methionine and adopts an alpha/beta-fold characte...

[ 1996, 1998, 2008, 2014 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 36, 37383, 1213, 7, 367 ]

5

[ "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 4, 2 ]

2

true

Domain

Domain of unknown function DUF218

DUF218

6

IPR003849

3,849

Preprotein translocase YajC

Preprotein_translocase_YajC

Family

22,569

false

Secretion across the inner membrane in some Gram-negative bacteria occurs via the preprotein translocase pathway. Proteins are produced in the cytoplasm as precursors, and require a chaperone subunit to direct them to the translocase component [ ]. From there, the mature proteins are either targeted to the outer membra...

[]

0

[ "PFAM", "PRINTS", "PANTHER", "SMART", "NCBIFAM" ]

[ "PF02699", "PR01853", "PTHR33909", "SM01323", "TIGR00739" ]

[ "YajC", "YAJCTRNLCASE", "", "YajC", "yajC" ]

[ 22556, 18181, 22140, 22518, 21681 ]

5

[ "GP", "GP" ]

[ "GenProp0209", "GenProp1132" ]

[ "GP:GenProp0209", "GP:GenProp1132" ]

2

[ "2rdd" ]

1

[ "PUB00007064", "PUB00017282", "PUB00017576", "PUB00017577" ]

[ "2202721", "12068816", "9305629", "9826342" ]

[ "The sec and prl genes of Escherichia coli.", "SecDFyajC forms a heterotetrameric complex with YidC.", "The SecDFyajC domain of preprotein translocase controls preprotein movement by regulating SecA membrane cycling.", "Cloning and sequencing of yajC and secD homologs of Brucella abortus and demonstration of ...

[ 1990, 2002, 1997, 1998 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Phage sp. ctnfz20", "unclassified sequences" ]

[ 22073, 42, 1, 453 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Preprotein translocase YajC

Preprotein_translocase_YajC

7

IPR003850

3,850

Phosphoribosylformylglycinamidine synthase subunit PurS

PurS

Family

12,150

false

Phosphoribosylformylglycinamidine(FGAM) synthetase, , catalyses the fourth step in the de novo purine biosynthetic pathway [ ]. 5-phosphoribosylformylglycinamide (FGAR) + glutamine + ATP = FGAM + glutamate + ADP + Pi In eukaryotes and many bacterial systems (including Escherichia coli and Salmonella typhimurium), the F...

[]

0

[ "HAMAP", "PFAM", "PANTHER", "NCBIFAM" ]

[ "MF_01926", "PF02700", "PTHR34696", "TIGR00302" ]

[ "PurS", "PurS", "", "" ]

[ 11459, 12149, 11787, 11638 ]

4

[ "EC", "GP", "METACYC", "METACYC", "METACYC" ]

[ "6.3.5.3", "GenProp0110", "PWY-6121", "PWY-6122", "PWY-6277" ]

[ "EC:6.3.5.3", "GP:GenProp0110", "METACYC:PWY-6121", "METACYC:PWY-6122", "METACYC:PWY-6277" ]

5

[ "1gtd", "1t4a", "1twj", "1vq3", "2cuw", "2dgb", "2yx5", "2zw2", "3d54", "8j3n" ]

10

[ "PUB00014926", "PUB00016817" ]

[ "10784038", "15301532" ]

[ "The yexA gene product is required for phosphoribosylformylglycinamidine synthetase activity in Bacillus subtilis.", "A model for the Bacillus subtilis formylglycinamide ribonucleotide amidotransferase multiprotein complex." ]

[ 2000, 2004 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 736, 11057, 10, 36, 311 ]

5

[]

0

true

Family

Phosphoribosylformylglycinamidine synthase subunit PurS

PurS

1

IPR003851

3,851

Zinc finger, Dof-type

Znf_Dof

Domain

18,308

false

This entry consists of proteins containing a Dof domain, which is a zinc finger DNA-binding domain that shows resemblance to the Cys2 zinc finger, although it has a longer putative loop where an extra Cys residue is conserved [ ]. AOBP, a DNA-binding protein in pumpkin (Cucurbita maxima), contains a 52 amino acid Dof d...

[ "GO:0003677", "GO:0006355" ]

[ "DNA binding", "regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PROSITE", "PROFILE" ]

[ "PF02701", "PS01361", "PS50884" ]

[ "Zn_ribbon_Dof", "ZF_DOF_1", "ZF_DOF_2" ]

[ 18307, 17345, 17932 ]

3

[ "PROSITEDOC" ]

[ "PDOC50884" ]

[ "PROSITEDOC:PDOC50884" ]

1

[ "8xuf" ]

1

[ "PUB00007566", "PUB00014077", "PUB00035804", "PUB00035805", "PUB00035806", "PUB00035807", "PUB00035812" ]

[ "9688549", "12665246", "17210253", "15963892", "15718139", "10529348", "11179890" ]

[ "Functional analyses of the Dof domain, a zinc finger DNA-binding domain, in a pumpkin DNA-binding protein AOBP.", "Zinc fingers--folds for many occasions.", "Sticky fingers: zinc-fingers as protein-recognition motifs.", "Multiple modes of RNA recognition by zinc finger proteins.", "Zinc finger proteins: ge...

[ 1998, 2002, 2007, 2005, 2005, 1999, 2001 ]

7

[]

0

null

[ "Viridiplantae" ]

[ 18308 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 148, 95, 166 ]

3

true

Domain

Zinc finger, Dof-type

Znf_Dof

3

IPR003852

3,852

Signal transduction histidine kinase, osmosensitive K+ channel sensor, N-terminal

Sig_transdc_His_kinase_KdpD_N

Domain

13,634

false

Signal transducing histidine kinases are the key elements in two-component signal transduction systems, which control complex processes such as the initiation of development in microorganisms [ , ]. Examples of histidine kinases are EnvZ, which plays a central role in osmoregulation [ ], and CheA, which plays a central...

[ "GO:0000155", "GO:0004673", "GO:0000160", "GO:0016020" ]

[ "phosphorelay sensor kinase activity", "protein histidine kinase activity", "phosphorelay signal transduction system", "membrane" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PFAM" ]

[ "PF02702" ]

[ "KdpD" ]

[ 13634 ]

1

[ "EC" ]

[ "2.7.13.3" ]

[ "EC:2.7.13.3" ]

1

[ "2r8r" ]

1

[ "PUB00000966", "PUB00007567", "PUB00007568", "PUB00007866", "PUB00011096", "PUB00013246", "PUB00013247", "PUB00013562", "PUB00013563", "PUB00020801" ]

[ "9989504", "9226259", "1532388", "11406410", "10966457", "8868347", "10426948", "8029829", "1482126", "11145881" ]

[ "Structure of CheA, a signal-transducing histidine kinase.", "The kdp system of Clostridium acetobutylicum: cloning, sequencing, and transcriptional regulation in response to potassium concentration.", "KdpD and KdpE, proteins that control expression of the kdpABC operon, are members of the two-component sensor...

[ 1999, 1997, 1992, 2001, 2000, 1996, 1999, 1994, 1992, 2000 ]

10

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "metagenomes" ]

[ 13541, 9, 17, 67 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Signal transduction histidine kinase, osmosensitive K+ channel sensor, N-terminal

Sig_transdc_His_kinase_KdpD_N

2

IPR003854

3,854

Gibberellin regulated protein

GASA

Family

6,614

false

This is the GASA gibberellin regulated cysteine rich protein (GRPs) family. The expression of these proteins is up-regulated by the plant hormone gibberellin, most of these proteins have a role in plant development and some of its members have antimicrobial activity [ , ]. There are 12 cysteine residues conserved withi...

[]

0

[ "PFAM" ]

[ "PF02704" ]

[ "GASA" ]

[ 6614 ]

1

[]

0

[ "5e5q", "5e5t", "5e5y", "8x0r", "8x67" ]

5

[ "PUB00096615", "PUB00096616", "PUB00096617", "PUB00096618" ]

[ "32506709", "23278887", "31784246", "11891250" ]

[ "Characterization of a 7 kDa pollen allergen belonging to the gibberellin-regulated protein family from three Cupressaceae species.", "Peamaclein--a new peach allergenic protein: similarities, differences and misleading features compared to Pru p 3.", "Gibberellin-regulated protein allergy: Clinical features an...

[ 2020, 2013, 2020, 2002 ]

4

[]

0

null

[ "Embryophyta", "Staphylococcus warneri" ]

[ 6613, 1 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 51, 26, 58 ]

3

true

Family

Gibberellin regulated protein

GASA

7

IPR003855

3,855

Potassium transporter

K+_transporter

Family

28,442

false

This is a family of K+ potassium transporters that are conserved across phyla, having both bacterial (KUP) [ ], yeast (HAK) [ ], and plant (AtKT/POT) [ ] sequences as members. POT1 from Arabidopsis thaliana plays an essential role in telomere maintenance [ ].

[ "GO:0015079", "GO:0071805", "GO:0016020" ]

[ "potassium ion transmembrane transporter activity", "potassium ion transmembrane transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PANTHER", "NCBIFAM" ]

[ "PTHR30540", "TIGR00794" ]

[ "", "kup" ]

[ 28427, 11901 ]

2

[]

0

[]

0

[ "PUB00007570", "PUB00007571", "PUB00007572", "PUB00068278" ]

[ "8226635", "7621817", "9350997", "17627276" ]

[ "Nucleotide sequence and 3'-end deletion studies indicate that the K(+)-uptake protein kup from Escherichia coli is composed of a hydrophobic core linked to a large and partially essential hydrophilic C terminus.", "A potassium transporter of the yeast Schwanniomyces occidentalis homologous to the Kup system of E...

[ 1993, 1995, 1997, 2007 ]

4

[]

[ "IPR023051" ]

0

1

0

[ "Bacteria", "Chlorovirus", "Eukaryota", "Methanomicrobia", "unclassified sequences" ]

[ 12708, 2, 15567, 48, 117 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 60, 1, 1, 66, 232 ]

5

true

Family

Potassium transporter

K+_transporter

1

IPR003856

3,856

Polysaccharide chain length determinant, N-terminal domain

LPS_length_determ_N

Domain

38,075

false

A number of related proteins are involved in the synthesis of lipopolysaccharide, O-antigen polysaccharide, capsule polysaccharide and exopolysaccharides. Chain length determinant protein (or wzz protein) is involved in lipopolysaccharide (lps) biosynthesis, conferring a modal distribution of chain length on the O-anti...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF02706" ]

[ "Wzz" ]

[ 38075 ]

1

[]

0

[ "4wl1", "6rbg", "7nhr", "7nhs", "7ni2", "7nib", "7nih", "7nii", "8bhw", "8c0e", "8p3o", "8p3p", "9exo", "9exp", "9exq", "9exr", "9i2q", "9i2r" ]

18

[ "PUB00007573", "PUB00007574" ]

[ "9573151", "10658645" ]

[ "The wzz (cld) protein in Escherichia coli: amino acid sequence variation determines O-antigen chain length specificity.", "Evaluation of Wzz/MPA1/MPA2 proteins based on the presence of coiled-coil regions." ]

[ 1998, 2000 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Inoviridae sp. ctDEu7", "Methanomicrobia", "unclassified sequences" ]

[ 37696, 21, 1, 3, 354 ]

5

[ "Escherichia coli (strain K12)" ]

[ 6 ]

1

true

Domain

Polysaccharide chain length determinant, N-terminal domain

LPS_length_determ_N

8

IPR003857

3,857

Major outer sheath protein, N-terminal

MOSP_N

Domain

887

false

This entry represents the N-terminal region of major outer sheath proteins from spirochaetales. Major outer sheath proteins are present on the bacterial cell surface. In Treponema denticola the major outer sheath protein (Msp) binds immobilized laminin and fibronectin, supporting the hypothesis that Msp mediates the ex...

[]

0

[ "PFAM" ]

[ "PF02707" ]

[ "MOSP_N" ]

[ 887 ]

1

[]

0

[]

0

[ "PUB00007575" ]

[ "9023187" ]

[ "Conservation of msp, the gene encoding the major outer membrane protein of oral Treponema spp." ]

[ 1997 ]

1

[]

0

null

[ "Treponema" ]

[ 887 ]

1

[]

0

true

Domain

Major outer sheath protein, N-terminal

MOSP_N

2

IPR003859

3,859

Beta-1,4-galactosyltransferase

Galactosyl_T

Family

13,621

false

Beta-1,4-galactosyltransferase is responsible for catalysing the transfer of galactose onto proteins or lipids [ ]. Studies on C.elegans have shown that the enzyme is required for susceptibility to pore-forming crystal toxins, together with glycosyltransferase genes bre-1, bre-2, bre-3 and bre-5 [ ]. In mammals, the pr...

[ "GO:0016757", "GO:0005975" ]

[ "glycosyltransferase activity", "carbohydrate metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PRINTS", "PANTHER" ]

[ "PR02050", "PTHR19300" ]

[ "B14GALTRFASE", "" ]

[ 12817, 13427 ]

2

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "...

[ "2.4.1", "2.4.1.-", "PWY-1901", "PWY-1961", "PWY-1981", "PWY-2021", "PWY-2881", "PWY-2901", "PWY-2902", "PWY-4421", "PWY-4801", "PWY-5094", "PWY-5105", "PWY-5129", "PWY-5139", "PWY-5160", "PWY-5161", "PWY-5268", "PWY-5284", "PWY-5286", "PWY-5310", "PWY-5312", "PWY-5313", ...

[ "EC:2.4.1", "EC:2.4.1.-", "METACYC:PWY-1901", "METACYC:PWY-1961", "METACYC:PWY-1981", "METACYC:PWY-2021", "METACYC:PWY-2881", "METACYC:PWY-2901", "METACYC:PWY-2902", "METACYC:PWY-4421", "METACYC:PWY-4801", "METACYC:PWY-5094", "METACYC:PWY-5105", "METACYC:PWY-5129", "METACYC:PWY-5139", ...

246

[ "1fgx", "1fr8", "1nf5", "1nhe", "1nkh", "1nmm", "1nqi", "1nwg", "1o0r", "1o23", "1oqm", "1pzt", "1pzy", "1tvy", "1tw1", "1tw5", "1yro", "2ae7", "2aec", "2aes", "2agd", "2ah9", "2fy7", "2fya", "2fyb", "2fyc", "2fyd", "3ee5", "3lw6", "4ee3", "4ee4", "4ee5"...

45

[ "PUB00064256", "PUB00066762", "PUB00066763" ]

[ "12944392", "10580128", "1714903" ]

[ "Resistance to a bacterial toxin is mediated by removal of a conserved glycosylation pathway required for toxin-host interactions.", "Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions.", "Evidence for a molecular distinction between Golgi ...

[ 2003, 1999, 1991 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes", "uncultured marine group II/III euryarchaeote AD1000_88_G11" ]

[ 128, 13341, 10, 141, 1 ]

5

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 26, 4, 38, 29, 26 ]

6

true

Family

Beta-1,4-galactosyltransferase

Galactosyl_T

3

IPR003860

3,860

Haemagglutinin-esterase glycoprotein, haemagglutinin domain

Hemagglutn-estrase_hemagglutn

Domain

917

false

Haemagglutinin-esterase fusion glycoprotein (HEF) is a multi-functional protein embedded in the viral envelope of several viruses, including influenza C virus, coronaviruses and toroviruses [ , ]. HEF is required for infectivity, and functions to recognise the host cell surface receptor, to fuse the viral and host cell...

[ "GO:0016788", "GO:0046789", "GO:0019064", "GO:0019031" ]

[ "hydrolase activity, acting on ester bonds", "host cell surface receptor binding", "fusion of virus membrane with host plasma membrane", "viral envelope" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PFAM" ]

[ "PF02710" ]

[ "Hema_HEFG" ]

[ 917 ]

1

[ "EC" ]

[ "3.1.1.53" ]

[ "EC:3.1.1.53" ]

1

[ "1flc", "3cl4", "3cl5", "3i1k", "3i1l", "3i26", "3i27", "4c7l", "4c7w", "4zxn", "5e5w", "5e62", "5e64", "5e65", "5e66", "5jif", "5jil", "5n11", "6y3y", "6yi5" ]

20

[ "PUB00010667", "PUB00033172" ]

[ "9817207", "16575523" ]

[ "Structure of the haemagglutinin-esterase-fusion glycoprotein of influenza C virus.", "Structure, function and evolution of the hemagglutinin-esterase proteins of corona- and toroviruses." ]

[ 1998, 2006 ]

2

[]

0

null

[ "Rhizophagus irregularis", "Viruses" ]

[ 1, 916 ]

2

[]

0

true

Domain

Haemagglutinin-esterase glycoprotein, haemagglutinin domain

Hemagglutn-estrase_hemagglutn

4

IPR003861

3,861

E4 protein

Papilloma_E4

Family

1,279

false

This is is a family of Papillomavirus proteins, E4, coded for by ORF4. A splice variant, E1--E4, exists but the function of neither E4 nor E1--E4 is known [ ].

[]

0

[ "PFAM" ]

[ "PF02711" ]

[ "Pap_E4" ]

[ 1279 ]

1

[]

0

[]

0

[ "PUB00007576" ]

[ "9454695" ]

[ "Identification of conserved hydrophobic C-terminal residues of the human papillomavirus type 1 E1E4 protein necessary for E4 oligomerisation in vivo." ]

[ 1998 ]

1

[]

0

null

[ "Papillomaviridae" ]

[ 1279 ]

1

[]

0

true

Family

E4 protein

Papilloma_E4

5

IPR003863

3,863

Domain of unknown function DUF220

DUF220

Domain

1,190

false

This entry consists of several Arabidopsis thaliana hypothetical proteins, none of which have any known function. They contain a conserved region with two cysteine residues. This domain exhibits structural similarities with members of the Bet v1-like superfamily and may play a role in lipid binding [ ].

[]

0

[ "PFAM" ]

[ "PF02713" ]

[ "DUF220" ]

[ 1190 ]

1

[]

0

[]

0

[ "PUB00099734" ]

[ "31068459" ]

[ "JASSY, a chloroplast outer membrane protein required for jasmonate biosynthesis." ]

[ 2019 ]

1

[]

0

null

[ "Streptophyta" ]

[ 1190 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 89, 3, 3 ]

3

true

Domain

Domain of unknown function DUF220

DUF220

5

IPR003864

3,864

CSC1/OSCA1-like, 7TM region

CSC1/OSCA1-like_7TM

Domain

25,077

false

This entry represents the seven transmembrane domain region of plant OSCA1, yeast PHM7 and RSN1 and CSC1-like protein 1 (also known as TRANSMEMBRANE PROTEIN 63A) [ , , ]. Members of this entry are mechanosensitive calcium-permeable ion channels consisting of an N-terminal transmembrane domain (RSN1_TM), a cytosolic dom...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF02714" ]

[ "RSN1_7TM" ]

[ 25077 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-6798695", "R-HSA-6798695", "R-MMU-6798695", "R-SCE-6798695", "R-SPO-6798695" ]

[ "REACTOME:R-DME-6798695", "REACTOME:R-HSA-6798695", "REACTOME:R-MMU-6798695", "REACTOME:R-SCE-6798695", "REACTOME:R-SPO-6798695" ]

5

[ "5z1f", "6ijz", "6jpf", "6mgv", "6mgw", "6oce", "8ehw", "8ehx", "8grn", "8gro", "8grs", "8gso", "8k0b", "8t56", "8t57", "8u53", "8wg3", "8wg4", "8wua", "8xaj", "8xng", "8xry", "8xs0", "8xs4", "8xs5", "8xvx", "8xvy", "8xvz", "8xw0", "8xw1", "8xw2", "8xw3"...

40

[ "PUB00063120", "PUB00070978", "PUB00075479", "PUB00076961", "PUB00100815", "PUB00100836" ]

[ "11102525", "15590821", "17005914", "24503647", "30498218", "30190597" ]

[ "New components of a system for phosphate accumulation and polyphosphate metabolism in Saccharomyces cerevisiae revealed by genomic expression analysis.", "Morphogenetic pathway of spore wall assembly in Saccharomyces cerevisiae.", "The yeast tumor suppressor homologue Sro7p is required for targeting of the sod...

[ 2000, 2004, 2006, 2014, 2018, 2018 ]

6

[]

0

null

[ "Eukaryota" ]

[ 25077 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 87, 21, 1, 7, 3, 5, 30, 12, 4, 3, 66 ]

11

true

Domain

CSC1/OSCA1-like, 7TM region

CSC1/OSCA1-like_7TM

7

IPR003869

3,869

Polysaccharide biosynthesis protein, CapD-like domain

Polysac_CapD-like

Domain

24,879

false

This domain is found in diverse bacterial polysaccharide biosynthesis proteins including the CapD protein from Staphylococcus aureus [ ], the WalL protein, mannosyl-transferase [ ], and several putative epimerases. The CapD protein is required for biosynthesis of type 1 capsular polysaccharide.

[]

0

[ "PFAM", "CDD" ]

[ "PF02719", "cd05237" ]

[ "Polysacc_synt_2", "UDP_invert_4-6DH_SDR_e" ]

[ 24879, 23027 ]

2

[]

0

[ "2gn4", "2gn6", "2gn8", "2gn9", "2gna", "3pvz", "3vvb", "3vvc", "3w1v", "4g5h", "4j2o", "4tqg", "5bju", "5bjv", "5bjw", "5bjx", "5bjy", "6bwc" ]

18

[ "PUB00007578", "PUB00007579" ]

[ "7961465", "9079898" ]

[ "Sequence analysis and molecular characterization of genes required for the biosynthesis of type 1 capsular polysaccharide in Staphylococcus aureus.", "Identification of additional genes required for O-antigen biosynthesis in Vibrio cholerae O1." ]

[ 1994, 1997 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 194, 23922, 76, 41, 646 ]

5

[]

0

true

Domain

Polysaccharide biosynthesis protein, CapD-like domain

Polysac_CapD-like

2

IPR003870

3,870

Domain of unknown function DUF222

DUF222

Domain

22,189

false

This domain is found in hypothetical proteins, many of them from Mycobacterium tuberculosis. The family has been called the 13E12 repeat family [ ]. The function of this domain is uncertain.

[]

0

[ "PFAM" ]

[ "PF02720" ]

[ "DUF222" ]

[ 22189 ]

1

[]

0

[]

0

[ "PUB00057273" ]

[ "12029045" ]

[ "Definition of the mycobacterial SOS box and use to identify LexA-regulated genes in Mycobacterium tuberculosis." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 21903, 10, 276 ]

3

[]

0

true

Domain

Domain of unknown function DUF222

DUF222

5

IPR003871

3,871

Replication protein A 70 kDa DNA-binding subunit B/D, first OB fold domain

RFA1B/D_OB_1st

Domain

10,441

false

This entry represents the first OB fold found Replication protein A 70 kDa DNA-binding subunit B/D from plants which are similar to human RPA1 (also called RPA70) and are part of the RPA complex. RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be i...

[]

0

[ "PFAM" ]

[ "PF02721" ]

[ "DUF223" ]

[ 10441 ]

1

[]

0

[]

0

[ "PUB00016304", "PUB00027748", "PUB00045121", "PUB00081058", "PUB00116530" ]

[ "15102447", "10473346", "16523492", "12598368", "9242902" ]

[ "From RPA to BRCA2: lessons from single-stranded DNA binding by the OB-fold.", "Replication protein A (RPA): the eukaryotic SSB.", "Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses.", "Nucleic acid recognition by OB-fold proteins.", "Replication protein...

[ 2004, 1999, 2006, 2003, 1997 ]

5

[]

0

null

[ "Eukaryota", "Photobacterium carnosum" ]

[ 10440, 1 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 142, 66, 144 ]

3

true

Domain

Replication protein A 70 kDa DNA-binding subunit B/D, first OB fold domain

RFA1B/D_OB_1st

3

IPR003874

3,874

CDC45

Family

5,071

false

CDC45 is an essential gene required for initiation of DNA replication in Saccharomyces cerevisiae (cell division control protein 45), forming a complex with MCM5/CDC46. Homologs of CDC45 have been identified in human [ ], mouse and the smut fungus, Melampsora spp., (tsd2 protein) among others.

[ "GO:0006270" ]

[ "DNA replication initiation" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF02724", "PTHR10507" ]

[ "CDC45", "" ]

[ 5046, 5001 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-68962", "R-HSA-176187", "R-HSA-176974", "R-HSA-68962", "R-HSA-69205", "R-MMU-176187", "R-MMU-68962", "R-SCE-176187", "R-SCE-68962", "R-SPO-176187", "R-SPO-68962" ]

[ "REACTOME:R-DDI-68962", "REACTOME:R-HSA-176187", "REACTOME:R-HSA-176974", "REACTOME:R-HSA-68962", "REACTOME:R-HSA-69205", "REACTOME:R-MMU-176187", "REACTOME:R-MMU-68962", "REACTOME:R-SCE-176187", "REACTOME:R-SCE-68962", "REACTOME:R-SPO-176187", "REACTOME:R-SPO-68962" ]

11

[ "3jc5", "3jc6", "3jc7", "5dgo", "5u8s", "5u8t", "6cc2", "6hv9", "6ptj", "6ptn", "6pto", "6raw", "6rax", "6ray", "6raz", "6skl", "6u0m", "6xtx", "6xty", "7pfo", "7plo", "7pmk", "7pmn", "7qhs", "7z13", "8b9a", "8b9b", "8b9c", "8b9d", "8j09", "8kg6", "8kg8"...

45

[ "PUB00007580" ]

[ "9660782" ]

[ "The human homolog of Saccharomyces cerevisiae CDC45." ]

[ 1998 ]

1

[]

0

null

[ "Eukaryota" ]

[ 5071 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 1, 1, 8, 5, 1, 5, 5, 1, 1, 6 ]

12

true

Family

CDC45

3

IPR003875

3,875

Paramyxoviridae nonstructural protein C

Paramyxovir_NSC

Family

327

false

This family consists of the polymerase accessory protein C from members of the paramyxoviridae.

[]

0

[ "PFAM" ]

[ "PF02725" ]

[ "Paramyxo_NS_C" ]

[ 327 ]

1

[]

0

[ "9dut", "9oce" ]

2

[]

0

[]

0

null

[ "Morbillivirus" ]

[ 327 ]

1

[]

0

true

Family

Paramyxoviridae nonstructural protein C

Paramyxovir_NSC

2

IPR003876

3,876

Arginine deiminase

Arg_deiminase

Family

9,355

false

This is a family of arginine deiminases, . These enzymes catalyse the conversion of arginine + H2O to citrulline + NH3. The family member from Streptococcus pyogenes has been characterised as an antitumour protein [ ].

[ "GO:0016990", "GO:0006527" ]

[ "arginine deiminase activity", "L-arginine catabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PIRSF", "PRINTS", "NCBIFAM" ]

[ "MF_00242", "PIRSF006356", "PR01466", "TIGR01078" ]

[ "Arg_deiminase", "Arg_deiminase", "ARGDEIMINASE", "arcA" ]

[ 7862, 8522, 9318, 4387 ]

4

[ "EC", "GP", "METACYC", "METACYC" ]

[ "3.5.3.6", "GenProp0639", "PWY-6344", "PWY-8187" ]

[ "EC:3.5.3.6", "GP:GenProp0639", "METACYC:PWY-6344", "METACYC:PWY-8187" ]

4

[ "1lxy", "1rxx", "1s9r", "2a9g", "2aaf", "2abr", "2aci", "4bof", "4e4j" ]

9

[ "PUB00007581" ]

[ "3123442" ]

[ "Antitumor activity of streptococcal acid glycoprotein produced by Streptococcus pyogenes Su." ]

[ 1987 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 91, 9095, 104, 65 ]

4

[]

0

true

Family

Arginine deiminase

Arg_deiminase

1

IPR003877

3,877

SPRY domain

SPRY_dom

Domain

126,565

false

The SPRY domain is a ~140-amino-acid protein interaction module involved in many important signalling pathways like RNA processing, regulation of histone H3 methylation, innate immunity, or embryonic development [ , , ]. It can be divided into 11 subfamilies based on amino acid sequence similarity or the presence of ad...

[ "GO:0005515" ]

[ "protein binding" ]

[ "molecular_function" ]

1

[ "PFAM", "SMART" ]

[ "PF00622", "SM00449" ]

[ "SPRY", "SPRY" ]

[ 124388, 115378 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-3134975", "R-BTA-8951664", "R-BTA-9755511", "R-BTA-983168", "R-CEL-3214841", "R-CEL-72163", "R-CEL-72203", "R-CEL-8936459", "R-CEL-9772755", "R-DDI-5675482", "R-DME-201722", "R-DME-8936459", "R-DME-8951664", "R-DME-9772755", "R-DME-983168", "R-DME-9861718", "R-DRE-5673001", ...

[ "REACTOME:R-BTA-3134975", "REACTOME:R-BTA-8951664", "REACTOME:R-BTA-9755511", "REACTOME:R-BTA-983168", "REACTOME:R-CEL-3214841", "REACTOME:R-CEL-72163", "REACTOME:R-CEL-72203", "REACTOME:R-CEL-8936459", "REACTOME:R-CEL-9772755", "REACTOME:R-DDI-5675482", "REACTOME:R-DME-201722", "REACTOME:R-DM...

110

[ "2afj", "2fbe", "2fnj", "2ihs", "2iwg", "2jk9", "2lm3", "2v24", "2vok", "2wl1", "2yyo", "3ek9", "3emw", "3f2o", "3j8h", "3kb5", "3toj", "3uv9", "3zo0", "4b3n", "4b8e", "4cfg", "4cg4", "4n7i", "4n7u", "4p9i", "4p9j", "4p9l", "4qt6", "4uwa", "4uwe", "4v1p"...

482

[ "PUB00005467", "PUB00033710", "PUB00033711", "PUB00033712", "PUB00033713", "PUB00039269", "PUB00041714", "PUB00085899", "PUB00086126", "PUB00095661", "PUB00130360" ]

[ "9204703", "8114113", "16498413", "9196055", "10223295", "16369487", "17189197", "23139046", "15713673", "27812363", "21199876" ]

[ "SPRY domains in ryanodine receptors (Ca(2+)-release channels).", "Evolutionary study of multigenic families mapping close to the human MHC class I region.", "Structural and functional insights into the B30.2/SPRY domain.", "B30.2-like domain proteins: a growing family.", "Protein fold analysis of the B30.2...

[ 1997, 1993, 2006, 1997, 1999, 2006, 2006, 2013, 2005, 2016, 2011 ]

11

[]

[ "IPR035754", "IPR035761", "IPR035762", "IPR035764", "IPR035768", "IPR035773", "IPR035774", "IPR035782", "IPR035783", "IPR048222" ]

0

10

0

[ "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 129, 126393, 29, 14 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 27, 43, 1069, 30, 269, 190, 3, 15, 212, 4, 3, 52 ]

12

true

Domain

SPRY domain

SPRY_dom

6

IPR003879

3,879

Butyrophylin-like, SPRY domain

Butyrophylin_SPRY

Domain

71,551

false

Several proteins that contain RING fingers also contain a well-conserved 40-residue cysteine-rich domain termed a B-box zinc finger. Often, one or two copies of the B-box are associated with a coiled coil domain ( ) in addition to the ring finger ( ), forming a tripartite motif. The tripartite motif is found in transcr...

[]

0

[ "PRINTS" ]

[ "PR01407" ]

[ "BUTYPHLNCDUF" ]

[ 71551 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-3134975", "R-BTA-9755511", "R-BTA-983168", "R-HSA-1169408", "R-HSA-168928", "R-HSA-1834941", "R-HSA-3134975", "R-HSA-3232142", "R-HSA-445355", "R-HSA-5656169", "R-HSA-5689896", "R-HSA-844456", "R-HSA-877300", "R-HSA-8851680", "R-HSA-8948751", "R-HSA-918233", "R-HSA-933541", ...

[ "REACTOME:R-BTA-3134975", "REACTOME:R-BTA-9755511", "REACTOME:R-BTA-983168", "REACTOME:R-HSA-1169408", "REACTOME:R-HSA-168928", "REACTOME:R-HSA-1834941", "REACTOME:R-HSA-3134975", "REACTOME:R-HSA-3232142", "REACTOME:R-HSA-445355", "REACTOME:R-HSA-5656169", "REACTOME:R-HSA-5689896", "REACTOME:R...

41

[ "2fbe", "2iwg", "2lm3", "2vok", "2wl1", "3kb5", "3uv9", "3zo0", "4b3n", "4b8e", "4cfg", "4cg4", "4n7i", "4n7u", "4v1p", "4wvm", "5hm7", "5lyg", "5lyk", "5zxk", "5zz3", "6flm", "6fln", "6ism", "6ita", "6j06", "6j0g", "6j0k", "6j0l", "6jbm", "6sjh", "6uma"...

230

[ "PUB00006018", "PUB00006153" ]

[ "8846787", "9923704" ]

[ "Novel topology of a zinc-binding domain from a protein involved in regulating early Xenopus development.", "RING fingers and B-boxes: zinc-binding protein-protein interaction domains." ]

[ 1995, 1998 ]

2

[ "IPR001870" ]

[ "IPR035033", "IPR035687", "IPR035727", "IPR035742", "IPR035752", "IPR035826", "IPR035827", "IPR035828", "IPR035829", "IPR035830", "IPR035831", "IPR037954", "IPR037958", "IPR037960", "IPR042753" ]

1

15

0

[ "Cyvirus", "Eukaryota", "Nocardioides malaquae", "bird metagenome" ]

[ 5, 71544, 1, 1 ]

4

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 982, 193, 132, 135 ]

4

true

Domain

Butyrophylin-like, SPRY domain

Butyrophylin_SPRY

1

IPR003882

3,882

Pistil-specific extensin-like protein

Pistil_extensin

Family

2,100

false

Extensins are plant cell-wall proteins; they can account for up to 20% of the dry weight of the cell wall. They are highly-glycosylated, possibly reflecting their interactions with cell-wall carbohydrates. Amongst their functions is cell wall strengthening in response to mechanical stress (e.g., during attack by pests,...

[]

0

[ "PRINTS" ]

[ "PR01218" ]

[ "PSTLEXTENSIN" ]

[ 2100 ]

1

[]

0

[]

0

[ "PUB00006108" ]

[ "1392607" ]

[ "Developmental expression of tobacco pistil-specific genes encoding novel extensin-like proteins." ]

[ 1992 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "mine drainage metagenome" ]

[ 263, 1833, 3, 1 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 2, 2, 2, 6 ]

5

true

Family

Pistil-specific extensin-like protein

Pistil_extensin

4

IPR003883

3,883

Extensin-like

Family

113

false

Extensins are plant cell-wall proteins; they can account for up to 20% of the dry weight of the cell wall. They are highly-glycosylated, possibly reflecting their interactions with cell-wall carbohydrates. Amongst their functions is cell wall strengthening in response to mechanical stress (e.g., during attack by pests,...

[ "GO:0005199" ]

[ "structural constituent of cell wall" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF02095" ]

[ "Extensin_1" ]

[ 113 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Streptomyces neyagawaensis" ]

[ 112, 1 ]

2

[]

0

true

Family

Extensin-like

8

IPR003884

3,884

Factor I / membrane attack complex

FacI_MAC

Domain

5,813

false

This domain is found in complement component proteins, complement component factor 1 and agrin. Complement components C5b, C6, C7 C8 and C9 are the constituents of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. ...

[]

0

[ "SMART" ]

[ "SM00057" ]

[ "FIMAC" ]

[ 5813 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-166665", "R-HSA-1971475", "R-HSA-2022928", "R-HSA-2024096", "R-HSA-216083", "R-HSA-3000171", "R-HSA-3000178", "R-HSA-3560783", "R-HSA-3560801", "R-HSA-3656237", "R-HSA-3656253", "R-HSA-419037", "R-HSA-4420332", "R-HSA-9694614", "R-HSA-975634", "R-HSA-977606", "R-HSA-9820960", ...

[ "REACTOME:R-HSA-166665", "REACTOME:R-HSA-1971475", "REACTOME:R-HSA-2022928", "REACTOME:R-HSA-2024096", "REACTOME:R-HSA-216083", "REACTOME:R-HSA-3000171", "REACTOME:R-HSA-3000178", "REACTOME:R-HSA-3560783", "REACTOME:R-HSA-3560801", "REACTOME:R-HSA-3656237", "REACTOME:R-HSA-3656253", "REACTOME:...

35

[ "2wcy", "2xrc", "3t5o", "4a5w", "4e0s", "5o32", "6h03", "6h04", "7nyc", "7nyd", "7q6c", "8b0f", "8b0g", "8b0h", "8s9p", "9b3h" ]

16

[]

0

[]

0

null

[ "Eumetazoa", "Kangiella spongicola" ]

[ 5812, 1 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 54, 20, 9, 14 ]

4

true

Domain

Factor I / membrane attack complex

FacI_MAC

2

IPR003886

3,886

NIDO domain

NIDO_dom

Domain

13,019

false

The ~180-residue NIDO domain is an extracellular domain of unknown function, found in nidogen (entactin) and hypothetical proteins. The NIDO domain is found in association with other domains, such as nidogen G2 β-barrel ( ), thyroglobulin type-1 ( ), LDLRB ( ), AMOP ( ), EGF-like ( ), VWFD, IPT/TIG, or sushi/CCP/SCR ( ...

[ "GO:0007160" ]

[ "cell-matrix adhesion" ]

[ "biological_process" ]

1

[ "PFAM", "PROFILE", "SMART" ]

[ "PF06119", "PS51220", "SM00539" ]

[ "NIDO", "NIDO", "NIDO" ]

[ 12882, 11167, 11498 ]

3

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "PDOC51220", "R-HSA-1474228", "R-HSA-163125", "R-HSA-3000157", "R-HSA-5083625", "R-HSA-5083632", "R-HSA-5083636", "R-HSA-5621480", "R-HSA-913709", "R-HSA-977068", "R-MMU-1474228", "R-MMU-163125", "R-MMU-3000157", "R-MMU-913709", "R-MMU-977068", "R-RNO-3000157", "R-RNO-913709", "R-R...

[ "PROSITEDOC:PDOC51220", "REACTOME:R-HSA-1474228", "REACTOME:R-HSA-163125", "REACTOME:R-HSA-3000157", "REACTOME:R-HSA-5083625", "REACTOME:R-HSA-5083632", "REACTOME:R-HSA-5083636", "REACTOME:R-HSA-5621480", "REACTOME:R-HSA-913709", "REACTOME:R-HSA-977068", "REACTOME:R-MMU-1474228", "REACTOME:R-M...

18

[]

0

[ "PUB00014202", "PUB00035311", "PUB00035312", "PUB00035313" ]

[ "11893501", "12084055", "15053982", "16500040" ]

[ "AMOP, a protein module alternatively spliced in cancer cells.", "Cloning, chromosomal localization and characterization of the murine mucin gene orthologous to human MUC4.", "Spatial and temporal expression pattern of a novel gene in the frog Xenopus laevis: correlations with adult intestinal epithelial differ...

[ 2002, 2002, 2004, 2006 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 3, 430, 12570, 16 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 8, 76, 3, 41, 14, 17 ]

6

true

Domain

NIDO domain

NIDO_dom

1

IPR003887

3,887

LEM domain

LEM_dom

Domain

8,133

false

The LEM (LAP2, emerin, MAN1) domain is a globular module of approximately 40 amino acids, which is mostly found in the nucleoplasmic portions of metazoan inner nuclear membrane proteins. The LEM domain has been shown to mediate binding to BAF (barrier-to-autointegration factor) and BAF-DNA complexes. BAF dimers bind to...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF03020", "PS50954", "SM00540" ]

[ "LEM", "LEM", "LEM" ]

[ 7672, 8012, 6956 ]

3

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "PDOC50954", "R-HSA-2980766", "R-HSA-2995383", "R-HSA-4419969", "R-HSA-8980692", "R-HSA-9013106", "R-HSA-9013148", "R-HSA-9013149", "R-HSA-9013404", "R-HSA-9013405", "R-HSA-9013408", "R-HSA-9013409", "R-HSA-9013423", "R-HSA-9035034", "R-HSA-9609523", "R-HSA-9668328", "R-HSA-9696264",...

[ "PROSITEDOC:PDOC50954", "REACTOME:R-HSA-2980766", "REACTOME:R-HSA-2995383", "REACTOME:R-HSA-4419969", "REACTOME:R-HSA-8980692", "REACTOME:R-HSA-9013106", "REACTOME:R-HSA-9013148", "REACTOME:R-HSA-9013149", "REACTOME:R-HSA-9013404", "REACTOME:R-HSA-9013405", "REACTOME:R-HSA-9013408", "REACTOME:...

36

[ "1gjj", "1h9f", "1jei", "2odc", "2odg", "6ghd", "6rpr", "7ndy" ]

8

[ "PUB00017332", "PUB00017333", "PUB00018424" ]

[ "10671519", "11435115", "11500367" ]

[ "MAN1, an inner nuclear membrane protein that shares the LEM domain with lamina-associated polypeptide 2 and emerin.", "Structural characterization of the LEM motif common to three human inner nuclear membrane proteins.", "Solution structure of the constant region of nuclear envelope protein LAP2 reveals two LE...

[ 2000, 2001, 2001 ]

3

[]

[ "IPR034989", "IPR035006" ]

0

2

0

[ "Bacteria", "Eukaryota", "Halorubrum", "metagenomes" ]

[ 71, 8052, 8, 2 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 54, 6, 21, 24, 30 ]

6

true

Domain

LEM domain

LEM_dom

9

IPR003888

3,888

FY-rich, N-terminal

FYrich_N

Conserved_site

13,027

false

The "FY-rich" domain N-terminal (FYRN) and "FY-rich" domain C-terminal (FYRC) sequence motifs are two poorly characterised phenylalanine/ tyrosine-rich regions of around 50 and 100 amino acids, respectively, that are found in a variety of chromatin-associated proteins [ , , , ]. They are particularly common in histone ...

[ "GO:0005634" ]

[ "nucleus" ]

[ "cellular_component" ]

1

[ "PFAM", "PROFILE", "SMART" ]

[ "PF05964", "PS51542", "SM00541" ]

[ "FYRN", "FYRN", "FYRN" ]

[ 11730, 12948, 10982 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DME-201722", "R-DME-8936459", "R-DME-8939236", "R-DME-9772755", "R-HSA-201722", "R-HSA-3214841", "R-HSA-3769402", "R-HSA-5617472", "R-HSA-8936459", "R-HSA-8939236", "R-HSA-9616222", "R-HSA-9772755", "R-HSA-9818564", "R-HSA-9841922", "R-HSA-9931510", "R-HSA-9931512", "R-HSA-9931521...

[ "REACTOME:R-DME-201722", "REACTOME:R-DME-8936459", "REACTOME:R-DME-8939236", "REACTOME:R-DME-9772755", "REACTOME:R-HSA-201722", "REACTOME:R-HSA-3214841", "REACTOME:R-HSA-3769402", "REACTOME:R-HSA-5617472", "REACTOME:R-HSA-8936459", "REACTOME:R-HSA-8939236", "REACTOME:R-HSA-9616222", "REACTOME:...

24

[ "2wzo" ]

1

[ "PUB00008126", "PUB00011448", "PUB00057968", "PUB00057969", "PUB00057970" ]

[ "10838566", "11779830", "9247308", "20506279", "12482972" ]

[ "Evidence of domain swapping within the jumonji family of transcription factors.", "Systematic identification of novel protein domain families associated with nuclear functions.", "Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosoph...

[ 2000, 2002, 1997, 2010, 2003 ]

5

[]

0

null

[ "Eukaryota" ]

[ 13027 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 36, 1, 73, 3, 38, 18, 10, 17, 70 ]

9

true

Conserved_site

FY-rich, N-terminal

FYrich_N

4

IPR003889

3,889

FY-rich, C-terminal

FYrich_C

Conserved_site

12,819

false

The "FY-rich" domain N-terminal (FYRN) and "FY-rich" domain C-terminal (FYRC) sequence motifs are two poorly characterised phenylalanine/ tyrosine-rich regions of around 50 and 100 amino acids, respectively, that are found in a variety of chromatin-associated proteins [ , , , ]. They are particularly common in histone ...

[ "GO:0005634" ]

[ "nucleus" ]

[ "cellular_component" ]

1

[ "PFAM", "PROFILE", "SMART" ]

[ "PF05965", "PS51543", "SM00542" ]

[ "FYRC", "FYRC", "FYRC" ]

[ 11814, 12590, 10286 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DME-201722", "R-DME-8936459", "R-DME-8939236", "R-DME-9772755", "R-HSA-201722", "R-HSA-3214841", "R-HSA-3769402", "R-HSA-5617472", "R-HSA-8936459", "R-HSA-8939236", "R-HSA-9616222", "R-HSA-9772755", "R-HSA-9818564", "R-HSA-9841922", "R-HSA-9931510", "R-HSA-9931512", "R-HSA-9931521...

[ "REACTOME:R-DME-201722", "REACTOME:R-DME-8936459", "REACTOME:R-DME-8939236", "REACTOME:R-DME-9772755", "REACTOME:R-HSA-201722", "REACTOME:R-HSA-3214841", "REACTOME:R-HSA-3769402", "REACTOME:R-HSA-5617472", "REACTOME:R-HSA-8936459", "REACTOME:R-HSA-8939236", "REACTOME:R-HSA-9616222", "REACTOME:...

24

[ "2wzo" ]

1

[ "PUB00008126", "PUB00011448", "PUB00057968", "PUB00057969", "PUB00057970" ]

[ "10838566", "11779830", "9247308", "20506279", "12482972" ]

[ "Evidence of domain swapping within the jumonji family of transcription factors.", "Systematic identification of novel protein domain families associated with nuclear functions.", "Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosoph...

[ 2000, 2002, 1997, 2010, 2003 ]

5

[]

0

null

[ "Eukaryota", "Gammaproteobacteria" ]

[ 12817, 2 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 37, 1, 73, 3, 34, 18, 9, 19, 86 ]

9

true

Conserved_site

FY-rich, C-terminal

FYrich_C

2

IPR003890

3,890

MIF4G-like, type 3

MIF4G-like_typ-3

Domain

40,474

false

MIF4G stands for middle domain of eukaryotic initiation factor 4G (eIF4G). eIF4G is a component of the translation initiation factor eIF4F complex and the cytoplasmic cap-binding protein complex (CBC). In the cytoplasm, cap binding complexes, distinct in their composition from nuclear cap-binding complexes, have import...

[ "GO:0003723", "GO:0005515" ]

[ "RNA binding", "protein binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM", "SMART" ]

[ "PF02854", "SM00543" ]

[ "MIF4G", "MIF4G" ]

[ 39072, 36899 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-111367", "R-CEL-113418", "R-CEL-159236", "R-CEL-674695", "R-CEL-6803529", "R-CEL-6807505", "R-CEL-72086", "R-CEL-72163", "R-CEL-72165", "R-CEL-72187", "R-CEL-72203", "R-CEL-73856", "R-CEL-77588", "R-CEL-77595", "R-CEL-975956", "R-CEL-975957", "R-CEL-9930044", "R-DDI-111367",...

[ "REACTOME:R-CEL-111367", "REACTOME:R-CEL-113418", "REACTOME:R-CEL-159236", "REACTOME:R-CEL-674695", "REACTOME:R-CEL-6803529", "REACTOME:R-CEL-6807505", "REACTOME:R-CEL-72086", "REACTOME:R-CEL-72163", "REACTOME:R-CEL-72165", "REACTOME:R-CEL-72187", "REACTOME:R-CEL-72203", "REACTOME:R-CEL-73856"...

211

[ "1h2t", "1h2u", "1h2v", "1h6k", "1hu3", "1n52", "1n54", "1uw4", "2i2o", "2vso", "2vsx", "3fex", "3fey", "3rk6", "4c9b", "4cek", "4cem", "4iul", "4jhj", "4jhk", "4lun", "5gm6", "5gmk", "5lj3", "5lj5", "5lqw", "5mps", "5mq0", "5mqf", "5oo6", "5oob", "5wsg"...

89

[ "PUB00019825" ]

[ "10973054" ]

[ "Novel eIF4G domain homologues linking mRNA translation with nonsense-mediated mRNA decay." ]

[ 2000 ]

1

[]

0

null

[ "Eukaryota", "Viruses", "metagenomes" ]

[ 40441, 12, 21 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 36, 11, 94, 20, 55, 54, 5, 30, 57, 6, 5, 116 ]

12

true

Domain

MIF4G-like, type 3

MIF4G-like_typ-3

4

IPR003891

3,891

Initiation factor eIF-4 gamma, MA3

Initiation_fac_eIF4g_MI

Domain

28,153

false

This entry represents the MI domain (after MA-3 and eIF4G), it is a protein-protein interaction module of ~130 amino acids [ , , ]. It appears in several translation factors and is found in: One copy in plant and animal eIF4G 1 and 2 (DAP-5/NAT1/p97) Two copies in the animal programmed cell death protein 4 (PDCD4) or M...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF02847", "PS51366", "SM00544" ]

[ "MA3", "MI", "MA3" ]

[ 27171, 27997, 25654 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-72163", "R-DDI-1169408", "R-DDI-156827", "R-DDI-166208", "R-DDI-450408", "R-DDI-72662", "R-DDI-72702", "R-DDI-975956", "R-DDI-975957", "R-DME-72163", "R-DRE-72163", "R-HSA-1169408", "R-HSA-156827", "R-HSA-166208", "R-HSA-429947", "R-HSA-450408", "R-HSA-72163", "R-HSA-72649",...

[ "REACTOME:R-CEL-72163", "REACTOME:R-DDI-1169408", "REACTOME:R-DDI-156827", "REACTOME:R-DDI-166208", "REACTOME:R-DDI-450408", "REACTOME:R-DDI-72662", "REACTOME:R-DDI-72702", "REACTOME:R-DDI-975956", "REACTOME:R-DDI-975957", "REACTOME:R-DME-72163", "REACTOME:R-DRE-72163", "REACTOME:R-HSA-1169408...

40

[ "1ug3", "2ggf", "2hm8", "2iol", "2ion", "2ios", "2kzt", "2nsz", "2rg8", "2zu6", "3eij", "3eiq", "3l6a", "5gm6", "5gmk", "5lj3", "5lj5", "5lqw", "5mps", "5mq0", "5mqf", "5wsg", "5xjc", "5ylz", "5yzg", "5z56", "5z57", "5z58", "6bk8", "6exn", "6ff7", "6icz"...

68

[ "PUB00019825", "PUB00035800", "PUB00041752", "PUB00043678" ]

[ "10973054", "10958635", "17060447", "15082783" ]

[ "Novel eIF4G domain homologues linking mRNA translation with nonsense-mediated mRNA decay.", "Eukaryote-specific domains in translation initiation factors: implications for translation regulation and evolution of the translation system.", "Structural basis for inhibition of translation by the tumor suppressor P...

[ 2000, 2000, 2007, 2004 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Faunusvirus sp.", "seawater metagenome" ]

[ 3, 28148, 1, 1 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 44, 2, 84, 20, 38, 31, 2, 34, 43, 2, 2, 80 ]

12

true

Domain

Initiation factor eIF-4 gamma, MA3

Initiation_fac_eIF4g_MI

6

IPR003892

3,892

Ubiquitin system component CUE

CUE

Domain

29,298

false

This domain promotes intramolecular monoubiquitination and has a dual role in mono- and poly-ubiquitination recognition, being involved in binding ubiquitin-conjugating enzymes (UBCs) [ , , ]. CUE domains also occur in two proteins of the IL-1 signal transduction pathway, tollip and TAB2.

[ "GO:0043130" ]

[ "ubiquitin binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PROFILE", "SMART" ]

[ "PF02845", "PS51140", "SM00546" ]

[ "CUE", "CUE", "CUE" ]

[ 22706, 28317, 16999 ]

3

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "PDOC51140", "R-BTA-6798695", "R-BTA-9020702", "R-CEL-532668", "R-DRE-532668", "R-DRE-6798695", "R-HSA-112126", "R-HSA-1251985", "R-HSA-168638", "R-HSA-202424", "R-HSA-2871837", "R-HSA-445989", "R-HSA-450302", "R-HSA-450321", "R-HSA-532668", "R-HSA-5357956", "R-HSA-5607764", "R-HSA...

[ "PROSITEDOC:PDOC51140", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-9020702", "REACTOME:R-CEL-532668", "REACTOME:R-DRE-532668", "REACTOME:R-DRE-6798695", "REACTOME:R-HSA-112126", "REACTOME:R-HSA-1251985", "REACTOME:R-HSA-168638", "REACTOME:R-HSA-202424", "REACTOME:R-HSA-2871837", "REACTOME:R-HSA...

59

[ "1mn3", "1otr", "1p3q", "1wgl", "2dae", "2dhy", "2di0", "2ejs", "2ekf", "2lvn", "2lvo", "2lvp", "2lvq", "2myx", "4g3o", "6h3a", "6qu1", "7z36", "9jao" ]

19

[ "PUB00018578", "PUB00019369", "PUB00094307" ]

[ "12628920", "12573224", "23665229" ]

[ "A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain.", "Ubiquitin signals protein trafficking via interaction with a novel ubiquitin binding domain in the membrane fusion regulator, Vps9p.", "Ubiquitin binding by a CUE domain regulates ubiquitin chain formation by ERAD E3 l...

[ 2003, 2003, 2013 ]

3

[]

[ "IPR035667", "IPR040195", "IPR041799", "IPR041800", "IPR041801", "IPR041803", "IPR041804", "IPR041806", "IPR041807", "IPR041808", "IPR041809", "IPR041810", "IPR041911", "IPR048056" ]

0

14

0

[ "Bacteria", "Eukaryota", "Hyperionvirus sp.", "marine metagenome" ]

[ 16, 29279, 1, 2 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 36, 4, 34, 14, 33, 32, 7, 20, 30, 8, 5, 63 ]

12

true

Domain

Ubiquitin system component CUE

CUE

7

IPR003893

3,893

Iroquois-class homeodomain protein

Iroquois_homeo

Domain

5,353

false

This is a motif found only in Iroquois-class homeodomain proteins. It has unknown function. Examples include iroquois-class homeodomain protein IRX-4, and homeobox proteins caupolican and araucan, which control proneural and vein forming genesand are positive transcriptional controllers of achaete-scute. They may act a...

[ "GO:0003677", "GO:0006355", "GO:0005634" ]

[ "DNA binding", "regulation of DNA-templated transcription", "nucleus" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "SMART" ]

[ "SM00548" ]

[ "IRO" ]

[ 5353 ]

1

[ "REACTOME" ]

[ "R-HSA-9831926" ]

[ "REACTOME:R-HSA-9831926" ]

1

[]

0

[]

0

[]

0

null

[ "Opisthokonta" ]

[ 5353 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 16, 7, 6, 10, 16 ]

6

true

Domain

Iroquois-class homeodomain protein

Iroquois_homeo

5

IPR003894

3,894

TAFH/NHR1

TAFH_NHR1

Domain

8,703

false

The TAF homology (TAFH) or Nervy homology region 1 (NHR1) domain is a domain of 95-100 amino acids present in eukaryotic proteins of the MTG/ETO family and whereof the core ~75-80 residues occur in TAF proteins. The transcription initiation TFIID complex is composed of TATA binding protein (TBP) and a number of TBP-ass...

[ "GO:0006351" ]

[ "DNA-templated transcription" ]

[ "biological_process" ]

1

[ "PFAM", "PROFILE", "SMART" ]

[ "PF07531", "PS51119", "SM00549" ]

[ "TAFH", "TAFH", "TAFH" ]

[ 8662, 8658, 8447 ]

3

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "PDOC51119", "R-CEL-674695", "R-CEL-73776", "R-CEL-73779", "R-CEL-75953", "R-CEL-76042", "R-DME-674695", "R-DME-6804756", "R-DME-73776", "R-DME-73779", "R-DME-75953", "R-DME-76042", "R-HSA-167161", "R-HSA-167162", "R-HSA-167172", "R-HSA-674695", "R-HSA-6804756", "R-HSA-73776", "R...

[ "PROSITEDOC:PDOC51119", "REACTOME:R-CEL-674695", "REACTOME:R-CEL-73776", "REACTOME:R-CEL-73779", "REACTOME:R-CEL-75953", "REACTOME:R-CEL-76042", "REACTOME:R-DME-674695", "REACTOME:R-DME-6804756", "REACTOME:R-DME-73776", "REACTOME:R-DME-73779", "REACTOME:R-DME-75953", "REACTOME:R-DME-76042", ...

28

[ "2h7b", "2knh", "2p6v", "2pp4", "5ecj", "6mzc", "6mzd", "6mzl", "6mzm", "7edx", "7eg7", "7eg8", "7eg9", "7ega", "7egb", "7egc", "7egd", "7ege", "7egf", "7egg", "7egi", "7egj", "7ena", "7enc", "8gxq", "8gxs", "8wak", "8wal", "8wan", "8wao", "8wap", "8waq"...

34

[ "PUB00014283", "PUB00017005", "PUB00017006", "PUB00017007" ]

[ "9790752", "9447981", "12559562", "10076566" ]

[ "CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family.", "The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1.", "The ETO (MTG8) gene family.", "Association of MTG8 (ETO/CDR), a leukemia-related protein, with serine/threonine ...

[ 1998, 1998, 2003, 1999 ]

4

[]

0

null

[ "Bacillati", "Metazoa" ]

[ 2, 8701 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 72, 10, 31, 20, 25 ]

6

true

Domain

TAFH/NHR1

TAFH_NHR1

8

IPR003895

3,895

Type III secretion system, SctE/BipB

T3SS_SctE/BipB

Family

706

false

Secretion of virulence factors in Gram-negative bacteria involves transportation of the protein across two membranes to reach the cell exterior [ ]. There have been four secretion systems described in animal enteropathogens, such as Salmonella and Yersinia, with further sequence similarities in plant pathogens like Ral...

[ "GO:0005576", "GO:0016020" ]

[ "extracellular region", "membrane" ]

[ "cellular_component", "cellular_component" ]

2

[ "PRINTS" ]

[ "PR01375" ]

[ "BACINVASINB" ]

[ 706 ]

1

[]

0

[ "3tul", "3u0c", "5wkq" ]

3

[ "PUB00003585", "PUB00007582", "PUB00007583", "PUB00020764", "PUB00053407", "PUB00053408", "PUB00053409", "PUB00053410", "PUB00151514", "PUB00151515", "PUB00151516", "PUB00151517" ]

[ "9618447", "7608068", "10564516", "12169593", "10051653", "14662750", "9009343", "16159789", "17367391", "19433542", "23544147", "34809452" ]

[ "Type III protein secretion systems in bacterial pathogens of animals and plants.", "Homologs of the Shigella IpaB and IpaC invasins are required for Salmonella typhimurium entry into cultured epithelial cells.", "Flagellar proteins and type III-exported virulence factors are the predominant proteins secreted i...

[ 1998, 1995, 1999, 2002, 1999, 2003, 1997, 2005, 2007, 2009, 2013, 2021 ]

12

[]

0

null

[ "Pseudomonadota" ]

[ 706 ]

1

[]

0

true

Family

Type III secretion system, SctE/BipB

T3SS_SctE/BipB

9

IPR003896

3,896

Bacterial exotoxin B

Bacterial_exotoxin_B

Family

340

false

A large group of bacterial exotoxins are referred to as "A/B toxins", essentially because they are formed from two subunits [ ]. The "A" subunit possesses enzyme activity, and is transferred to the host cell following a conformational change in the membrane-bound transport "B" subunit. Clostridial species are one of th...

[ "GO:0005576" ]

[ "extracellular region" ]

[ "cellular_component" ]

1

[ "PRINTS" ]

[ "PR01391" ]

[ "BINARYTOXINB" ]

[ 340 ]

1

[ "REACTOME" ]

[ "R-HSA-5210891" ]

[ "REACTOME:R-HSA-5210891" ]

1

[ "1acc", "1t6b", "1tzn", "1tzo", "2j42", "3hvd", "3j9c", "3kwv", "3mhz", "3q8a", "3q8b", "3q8c", "3q8e", "3q8f", "3tew", "3tex", "3tey", "3tez", "4ee2", "4h2a", "4nam", "5fr3", "6klo", "6klw", "6klx", "6o2m", "6o2n", "6o2o", "6okr", "6oks", "6okt", "6oku"...

75

[ "PUB00006620", "PUB00006643", "PUB00007584", "PUB00007585", "PUB00010540" ]

[ "10802189", "8225592", "9659689", "3148491", "1910002" ]

[ "Production of actin-specific ADP-ribosyltransferase (binary toxin) by strains of Clostridium difficile.", "Characterization of Clostridium perfringens iota-toxin genes and expression in Escherichia coli.", "The gene for component-II of botulinum C2 toxin.", "Sequence and analysis of the DNA encoding protecti...

[ 2000, 1993, 1998, 1988, 1991 ]

5

[]

0

null

[ "Bacteria", "Methanosarcina barkeri" ]

[ 337, 3 ]

2

[]

0

true

Family

Bacterial exotoxin B

Bacterial_exotoxin_B

1

IPR003897

3,897

Clostridium enterotoxin

Clenterotox

Family

82

false

Clostridial species are one of the major causes of food poisoning/gastro-intestinal illnesses. They are Gram-positive, spore-forming rods that occur naturally in the soil [ ]. Among the family are: Clostridium botulinum, which produces one of the most potent toxins in existence; Clostridium tetani, causative agent of t...

[ "GO:0005576" ]

[ "extracellular region" ]

[ "cellular_component" ]

1

[ "PFAM", "PRINTS" ]

[ "PF03505", "PR01394" ]

[ "Clenterotox", "CLENTEROTOXN" ]

[ 82, 67 ]

2

[ "GP" ]

[ "GenProp0707" ]

[ "GP:GenProp0707" ]

1

[ "2quo", "2xh6", "2yhj", "2zoe", "2zs6", "3am2", "3win", "3x29", "3ziw", "3zix", "4en6", "4en7", "4en8", "4en9", "4lo4", "4lo5", "4lo6", "4lo7", "4lo8", "4p5h", "4qd2", "5b2g", "6ake", "6akf", "6akg", "6ov2", "6ov3", "7kp4", "7tdm", "7tdn", "8u4v", "8u5b"...

49

[ "PUB00007586", "PUB00007587", "PUB00007588", "PUB00047334", "PUB00091109" ]

[ "8335373", "9087440", "9334247", "17581814", "22684008" ]

[ "Cloning, nucleotide sequencing, and expression of the Clostridium perfringens enterotoxin gene in Escherichia coli.", "Molecular cloning and functional characterization of the receptor for Clostridium perfringens enterotoxin.", "Clostridium perfringens enterotoxin utilizes two structurally related membrane pro...

[ 1993, 1997, 1997, 2007, 2012 ]

5

[]

0

null

[ "Bacillota", "unclassified Caudoviricetes" ]

[ 78, 4 ]

2

[]

0

true

Family

Clostridium enterotoxin

Clenterotox

3

IPR003898

3,898

Bordetella pertussis toxin A

Borpert_toxA

Family

503

false

A large group of bacterial exotoxins are referred to as "A/B toxins", essentially because they are formed from two subunits [ ]. The "A" subunit possesses enzyme activity, and is transferred to the host cell following a conformational change in the membrane-bound transport "B" subunit [ ]. Bordetella pertussis is the c...

[ "GO:0003950", "GO:0005576" ]

[ "NAD+ poly-ADP-ribosyltransferase activity", "extracellular region" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM", "PRINTS" ]

[ "PF02917", "PR01395" ]

[ "Pertussis_S1", "BORPETOXINA" ]

[ 503, 243 ]

2

[]

0

[ "1bcp", "1prt", "1pto", "4k6l", "4tlv", "4tlw", "4z9c", "4z9d", "6ro0", "6vx4", "7ee6", "7ski", "7skk", "7sky", "7sne", "7u6z", "9e3h", "9e3j", "9e3k", "9e3l", "9kyb", "9kyc", "9kyd", "9kye", "9mr7" ]

25

[ "PUB00006643", "PUB00007589", "PUB00007590", "PUB00007591", "PUB00007592" ]

[ "8225592", "3704651", "2873570", "2737291", "8075982" ]

[ "Characterization of Clostridium perfringens iota-toxin genes and expression in Escherichia coli.", "Pertussis toxin gene: nucleotide sequence and genetic organization.", "Cloning and sequencing of the pertussis toxin genes: operon structure and gene duplication.", "Identification of an active-site residue in...

[ 1993, 1986, 1986, 1989, 1994 ]

5

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 493, 10 ]

2

[]

0

true

Family

Bordetella pertussis toxin A

Borpert_toxA

2

IPR003899

3,899

Bordetella pertussis toxin B

ToxinB_BORPE

Family

26

false

A large group of bacterial exotoxins are referred to as "A/B toxins", essentially because they are formed from two subunits [ ]. The "A" subunit possesses enzyme activity, and is transferred to the host cell following a conformational change in the membrane-bound transport "B" subunit [ ]. Bordetella pertussis is the c...

[ "GO:0005576" ]

[ "extracellular region" ]

[ "cellular_component" ]

1

[ "PRINTS" ]

[ "PR01396" ]

[ "BORPETOXINB" ]

[ 26 ]

1

[]

0

[ "1bcp", "1prt", "1pto", "6ro0", "9e3h", "9e3j", "9e3k", "9e3l", "9mr7" ]

9

[ "PUB00006643", "PUB00007589", "PUB00007590", "PUB00007592" ]

[ "8225592", "3704651", "2873570", "8075982" ]

[ "Characterization of Clostridium perfringens iota-toxin genes and expression in Escherichia coli.", "Pertussis toxin gene: nucleotide sequence and genetic organization.", "Cloning and sequencing of the pertussis toxin genes: operon structure and gene duplication.", "The crystal structure of pertussis toxin." ...

[ 1993, 1986, 1986, 1994 ]

4

[]

0

null

[ "Pseudomonadota" ]

[ 26 ]

1

[]

0

true

Family

Bordetella pertussis toxin B

ToxinB_BORPE

8

IPR003901

3,901

Methyl-coenzyme M reductase, protein D

Me_CoM_Rdtase_D

Family

322

false

Methyl-coenzyme M reductase (MCR) catalyses the reduction of methyl-coenzyme M (CH3-SCoM) and coenzyme B (HS-CoB) to methane and the corresponding heterosulphide CoM-S-S-CoB ( ), the final step in methane biosynthesis. This reaction proceeds under anaerobic conditions by methanogenic Archaea [ ], and requires a nickel-...

[ "GO:0015948" ]

[ "methanogenesis" ]

[ "biological_process" ]

1

[ "PFAM", "PIRSF", "NCBIFAM" ]

[ "PF02505", "PIRSF005636", "TIGR03260" ]

[ "MCR_D", "McrD", "met_CoM_red_D" ]

[ 322, 288, 302 ]

3

[ "GP", "GP" ]

[ "GenProp0719", "GenProp0722" ]

[ "GP:GenProp0719", "GP:GenProp0722" ]

2

[ "8gf5", "8gf6", "8w33" ]

3

[ "PUB00006391", "PUB00007594", "PUB00007595", "PUB00010614", "PUB00035993", "PUB00035994" ]

[ "9367957", "8863453", "3170483", "11491299", "16260307", "16234924" ]

[ "Crystal structure of methyl-coenzyme M reductase: the key enzyme of biological methane formation.", "Phylogeny of Methanopyrus kandleri based on methyl coenzyme M reductase operons.", "Structure and comparative analysis of the genes encoding component C of methyl coenzyme M reductase in the extremely thermophi...

[ 1997, 1996, 1988, 2001, 2005, 2005 ]

6

[]

0

null

[ "Archaea", "ecological metagenomes" ]

[ 317, 5 ]

2

[]

0

true

Family

Methyl-coenzyme M reductase, protein D

Me_CoM_Rdtase_D

5

IPR003902

3,902

Transcription regulator GCM domain

Tscrpt_reg_GCM

Domain

2,238

false

GCM transcription factors are a family of proteins which contain a GCM motif. The GCM motif is a domain that has been identified in proteins belonging to a family of transcriptional regulators involved in fundamental developmental processes which comprise Drosophila melanogaster GCM and its mammalian homologues [ , , ,...

[ "GO:0003677", "GO:0006355" ]

[ "DNA binding", "regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PROFILE" ]

[ "PF03615", "PS50807" ]

[ "GCM", "GCM" ]

[ 2079, 2226 ]

2

[ "PROSITEDOC" ]

[ "PDOC50807" ]

[ "PROSITEDOC:PDOC50807" ]

1

[ "1odh" ]

1

[ "PUB00007596", "PUB00007597", "PUB00007598", "PUB00007599", "PUB00011125" ]

[ "8962155", "9114061", "9580683", "10671510", "12682016" ]

[ "The gcm-motif: a novel DNA-binding motif conserved in Drosophila and mammals.", "The regulator of early gliogenesis glial cells missing is a transcription factor with a novel type of DNA-binding domain.", "Structural requirements for DNA binding of GCM proteins.", "Protein stability and domain topology deter...

[ 1996, 1997, 1998, 2000, 2003 ]

5

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "ecological metagenomes" ]

[ 54, 2176, 6, 2 ]

4

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 3, 5, 4 ]

5

true

Domain

Transcription regulator GCM domain

Tscrpt_reg_GCM

3

IPR003903

3,903

Ubiquitin interacting motif

UIM_dom

Conserved_site

55,317

false

The Ubiquitin Interacting Motif (UIM), or 'LALAL-motif', is a stretch of about 20 amino acid residues, which was first described in the 26S proteasome subunit PSD4/RPN-10 that is known to recognise ubiquitin [ , ]. In addition, the UIM is found, often in tandem or triplet arrays, in a variety of proteins either involve...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF02809", "PS50330", "SM00726" ]

[ "UIM", "UIM", "UIM" ]

[ 14860, 52279, 33608 ]

3

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "PDOC50330", "R-BTA-182971", "R-BTA-432720", "R-BTA-5689880", "R-BTA-6807004", "R-BTA-8856825", "R-BTA-8856828", "R-BTA-9013420", "R-BTA-917729", "R-BTA-9706019", "R-CEL-182971", "R-CEL-5689877", "R-CEL-6807004", "R-CEL-8856825", "R-CEL-8856828", "R-CEL-9013420", "R-CEL-917729", "R...

[ "PROSITEDOC:PDOC50330", "REACTOME:R-BTA-182971", "REACTOME:R-BTA-432720", "REACTOME:R-BTA-5689880", "REACTOME:R-BTA-6807004", "REACTOME:R-BTA-8856825", "REACTOME:R-BTA-8856828", "REACTOME:R-BTA-9013420", "REACTOME:R-BTA-917729", "REACTOME:R-BTA-9706019", "REACTOME:R-CEL-182971", "REACTOME:R-CE...

163

[ "1o06", "1p9c", "1p9d", "1q0v", "1q0w", "1uel", "1yx4", "1yx5", "1yx6", "2d3g", "2kde", "2kdf", "2kdi", "2klz", "2mkf", "2mkg", "2mux", "2rr9", "3a1q", "3jco", "3jcp", "4cr2", "4cr3", "4cr4", "4xkh", "5a5b", "5gjq", "5gjr", "5ixf", "5l4k", "5ln3", "5m32"...

151

[ "PUB00007601", "PUB00018086", "PUB00018255", "PUB00018256", "PUB00018257", "PUB00044081" ]

[ "9488668", "12062168", "11406394", "12121618", "11919614", "1919637" ]

[ "Characterization of two polyubiquitin binding sites in the 26 S protease subunit 5a.", "From UBA to UBX: new words in the ubiquitin vocabulary.", "A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems.", "The ubiquitin-interacting motifs target the...

[ 1998, 2002, 2001, 2002, 2002, 1991 ]

6

[]

0

null

[ "Bacteria", "Eukaryota", "Thermoproteus sp. AZ2", "Viruses", "metagenomes" ]

[ 142, 55157, 1, 3, 14 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 65, 10, 147, 27, 265, 70, 7, 36, 99, 7, 7, 107 ]

12

true

Conserved_site

Ubiquitin interacting motif

UIM_dom

6

IPR003904

3,904

Apelin receptor

Apelin_rcpt

Family

171

false

G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can...

[ "GO:0004930", "GO:0007186", "GO:0016020" ]

[ "G protein-coupled receptor activity", "G protein-coupled receptor signaling pathway", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01416" ]

[ "APJRECEPTOR" ]

[ 171 ]

1

[ "IUPHAR", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "36", "R-HSA-375276", "R-HSA-418594", "R-MMU-375276", "R-MMU-418594", "R-RNO-375276", "R-RNO-418594" ]

[ "IUPHAR:36", "REACTOME:R-HSA-375276", "REACTOME:R-HSA-418594", "REACTOME:R-MMU-375276", "REACTOME:R-MMU-418594", "REACTOME:R-RNO-375276", "REACTOME:R-RNO-418594" ]

7

[ "2lot", "2lou", "2lov", "2low", "5vbl", "6knm", "7sus", "7w0l", "7w0m", "7w0n", "7w0o", "7w0p", "8s4d", "8xqe", "8xqf", "8xqi", "8xqj", "8xzf", "8xzg", "8xzh", "8xzi", "8xzj", "8z74", "8z7j", "9jh3", "9kuv", "9kuw", "9kux" ]

28

[ "PUB00000131", "PUB00002477", "PUB00004960", "PUB00004961", "PUB00007602", "PUB00007603", "PUB00007604", "PUB00053635", "PUB00063577", "PUB00063578", "PUB00063579", "PUB00063580", "PUB00063816", "PUB00095416", "PUB00095417" ]

[ "2111655", "2830256", "8386361", "8170923", "8294032", "9792798", "10617103", "12679517", "8081729", "15914470", "18948278", "16753280", "23020293", "28137936", "25639753" ]

[ "G proteins in signal transduction.", "G protein involvement in receptor-effector coupling.", "Design of a discriminating fingerprint for G-protein-coupled receptors.", "Fingerprinting G-protein-coupled receptors.", "A human gene that shows identity with the gene encoding the angiotensin receptor is located...

[ 1990, 1988, 1993, 1994, 1993, 1998, 2000, 2003, 1994, 2005, 2009, 2006, 2013, 2017, 2015 ]

15

[ "IPR000276" ]

[]

1

0

1

[ "Amniota" ]

[ 171 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 3, 2 ]

3

true

Family

Apelin receptor

Apelin_rcpt

1

IPR003905

3,905

Growth hormone secretagogue receptor/motilin receptor

GHS-R/MTLR

Family

2,254

false

G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can...

[ "GO:0007186", "GO:0016020" ]

[ "G protein-coupled receptor signaling pathway", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PRINTS" ]

[ "PR01417" ]

[ "GHSRECEPTOR" ]

[ 2254 ]

1

[ "IUPHAR", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "246", "R-HSA-375276", "R-HSA-416476", "R-MMU-416476", "R-RNO-416476", "R-SSC-416476" ]

[ "IUPHAR:246", "REACTOME:R-HSA-375276", "REACTOME:R-HSA-416476", "REACTOME:R-MMU-416476", "REACTOME:R-RNO-416476", "REACTOME:R-SSC-416476" ]

6

[ "6ko5", "7f83", "7f9y", "7f9z", "7na7", "7na8", "7w2z", "8ibu", "8ibv", "8jsr", "9jmc", "9jmd", "9uy3", "9v2n" ]

14

[ "PUB00000131", "PUB00002477", "PUB00004960", "PUB00004961", "PUB00053635", "PUB00063577", "PUB00063578", "PUB00063579", "PUB00063580", "PUB00063816", "PUB00088962", "PUB00088971", "PUB00088972" ]

[ "2111655", "2830256", "8386361", "8170923", "12679517", "8081729", "15914470", "18948278", "16753280", "23020293", "24100676", "11813507", "16628271" ]

[ "G proteins in signal transduction.", "G protein involvement in receptor-effector coupling.", "Design of a discriminating fingerprint for G-protein-coupled receptors.", "Fingerprinting G-protein-coupled receptors.", "The G protein-coupled receptor repertoires of human and mouse.", "GCRDb: a G-protein-coup...

[ 1990, 1988, 1993, 1994, 2003, 1994, 2005, 2009, 2006, 2013, 2013, 2001, 2006 ]

13

[ "IPR000276" ]

[]

1

0

1

[ "Chordata" ]

[ 2254 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 2, 3, 4 ]

4

true

Family

Growth hormone secretagogue receptor/motilin receptor

GHS-R/MTLR

5

IPR003906

3,906

Galanin receptor 1

GAL1_rcpt

Family

1,050

false

Galanin is involved in a variety of physiological mechanisms and disease states, from appetite and neuroregeneration to seizures and pain [ , ]. The actions of galanin are mediated through interaction with specific membrane receptors. Three receptor subtypes have been identified; Galanin receptor 1 (GALR1), Galanin rec...

[ "GO:0004966", "GO:0007186", "GO:0007194", "GO:0007204", "GO:0016020" ]

[ "galanin receptor activity", "G protein-coupled receptor signaling pathway", "negative regulation of adenylate cyclase activity", "positive regulation of cytosolic calcium ion concentration", "membrane" ]

[ "molecular_function", "biological_process", "biological_process", "biological_process", "cellular_component" ]

5

[ "PRINTS" ]

[ "PR01418" ]

[ "GALANIN1R" ]

[ 1050 ]

1

[ "IUPHAR", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "243", "R-HSA-375276", "R-HSA-418594", "R-MMU-375276", "R-MMU-418594", "R-RNO-375276", "R-RNO-418594" ]

[ "IUPHAR:243", "REACTOME:R-HSA-375276", "REACTOME:R-HSA-418594", "REACTOME:R-MMU-375276", "REACTOME:R-MMU-418594", "REACTOME:R-RNO-375276", "REACTOME:R-RNO-418594" ]

7

[ "7wq3", "7xjj" ]

2

[ "PUB00007607", "PUB00007608", "PUB00007609", "PUB00063814", "PUB00066627", "PUB00066628", "PUB00066629", "PUB00066630", "PUB00066631", "PUB00066632", "PUB00066633", "PUB00066634", "PUB00066635", "PUB00066636", "PUB00066637", "PUB00066639", "PUB00066640", "PUB00066647", "PUB000666...

[ "9578554", "10689365", "9722565", "8750821", "17604107", "16052044", "9126874", "7682064", "2417156", "10619483", "15670772", "1281259", "8734340", "12769595", "23233848", "7524088", "8670213", "2463283", "2471574" ]

[ "Differential intracellular signaling of the GalR1 and GalR2 galanin receptor subtypes.", "Galanin receptor subtypes.", "Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.", "Cloning and characterization of the rat GALR1 galanin receptor fro...

[ 1998, 2000, 1998, 1995, 2007, 2005, 1997, 1993, 1985, 2000, 2005, 1992, 1996, 2002, 2012, 1994, 1996, 1988, 1989 ]

19

[ "IPR000405" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 1050 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1, 3 ]

4

true

Family

Galanin receptor 1

GAL1_rcpt

3

IPR003907

3,907

Galanin receptor 2

GAL2_rcpt

Family

165

false

Galanin is involved in a variety of physiological mechanisms and disease states, from appetite and neuroregeneration to seizures and pain [ , ]. The actions of galanin are mediated through interaction with specific membrane receptors. Three receptor subtypes have been identified; Galanin receptor 1 (GALR1), Galanin rec...

[ "GO:0004966", "GO:0007186", "GO:0007194", "GO:0007204", "GO:0016020" ]

[ "galanin receptor activity", "G protein-coupled receptor signaling pathway", "negative regulation of adenylate cyclase activity", "positive regulation of cytosolic calcium ion concentration", "membrane" ]

[ "molecular_function", "biological_process", "biological_process", "biological_process", "cellular_component" ]

5

[ "PRINTS" ]

[ "PR01419" ]

[ "GALANIN2R" ]

[ 165 ]

1

[ "IUPHAR", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "244", "R-HSA-375276", "R-HSA-418594", "R-MMU-375276", "R-MMU-418594", "R-RNO-375276", "R-RNO-418594" ]

[ "IUPHAR:244", "REACTOME:R-HSA-375276", "REACTOME:R-HSA-418594", "REACTOME:R-MMU-375276", "REACTOME:R-MMU-418594", "REACTOME:R-RNO-375276", "REACTOME:R-RNO-418594" ]

7

[ "7wq4", "7xbd", "7xjk", "7xjl" ]

4

[ "PUB00007607", "PUB00007608", "PUB00063814", "PUB00066627", "PUB00066628", "PUB00066629", "PUB00066630", "PUB00066631", "PUB00066632", "PUB00066633", "PUB00066634", "PUB00066635", "PUB00066636", "PUB00066637", "PUB00066641", "PUB00066642", "PUB00066643", "PUB00066645", "PUB000666...

[ "9578554", "10689365", "8750821", "17604107", "16052044", "9126874", "7682064", "2417156", "10619483", "15670772", "1281259", "8734340", "12769595", "23233848", "9427506", "10379831", "9685625", "9305929", "9880084", "2463283", "2471574" ]

[ "Differential intracellular signaling of the GalR1 and GalR2 galanin receptor subtypes.", "Galanin receptor subtypes.", "Cloning and characterization of the rat GALR1 galanin receptor from Rin14B insulinoma cells.", "The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implic...

[ 1998, 2000, 1995, 2007, 2005, 1997, 1993, 1985, 2000, 2005, 1992, 1996, 2002, 2012, 1997, 1999, 1998, 1997, 1998, 1988, 1989 ]

21

[ "IPR000405" ]

[]

1

0

1

[ "Eukaryota" ]

[ 165 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 3 ]

3

true

Family

Galanin receptor 2

GAL2_rcpt

6

IPR003912

3,912

Protease-activated receptor

Protea_act_rcpt

Family

4,250

false

G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can...

[ "GO:0015057", "GO:0007596", "GO:0070493", "GO:0016020" ]

[ "thrombin-activated receptor activity", "blood coagulation", "thrombin-activated receptor signaling pathway", "membrane" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PRINTS" ]

[ "PR01428" ]

[ "PROTEASEAR" ]

[ 4250 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-140875", "R-HSA-375276", "R-HSA-416476", "R-HSA-456926", "R-MMU-140875", "R-MMU-375276", "R-MMU-416476", "R-MMU-456926", "R-RNO-140875", "R-RNO-375276", "R-RNO-416476", "R-RNO-456926" ]

[ "REACTOME:R-HSA-140875", "REACTOME:R-HSA-375276", "REACTOME:R-HSA-416476", "REACTOME:R-HSA-456926", "REACTOME:R-MMU-140875", "REACTOME:R-MMU-375276", "REACTOME:R-MMU-416476", "REACTOME:R-MMU-456926", "REACTOME:R-RNO-140875", "REACTOME:R-RNO-375276", "REACTOME:R-RNO-416476", "REACTOME:R-RNO-456...

12

[ "5nj6", "8xor", "8xos", "8zmd", "8zme", "9d0a", "9d4z", "9e7r" ]

8

[ "PUB00000131", "PUB00002477", "PUB00002945", "PUB00004960", "PUB00004961", "PUB00007615", "PUB00007616", "PUB00053635", "PUB00063577", "PUB00063578", "PUB00063579", "PUB00063580", "PUB00063816" ]

[ "2111655", "2830256", "7890726", "8386361", "8170923", "9087410", "8784787", "12679517", "8081729", "15914470", "18948278", "16753280", "23020293" ]

[ "G proteins in signal transduction.", "G protein involvement in receptor-effector coupling.", "The mouse proteinase-activated receptor-2 cDNA and gene. Molecular cloning and functional expression.", "Design of a discriminating fingerprint for G-protein-coupled receptors.", "Fingerprinting G-protein-coupled ...

[ 1990, 1988, 1995, 1993, 1994, 1997, 1996, 2003, 1994, 2005, 2009, 2006, 2013 ]

13

[ "IPR000276" ]

[ "IPR000935", "IPR002281", "IPR003943", "IPR003944", "IPR027669" ]

1

5

0

[ "Vertebrata" ]

[ 4250 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 25, 5, 10, 12 ]

4

true

Family

Protease-activated receptor

Protea_act_rcpt

7

IPR003913

3,913

Tuberin

Family

2,942

false

Tuberous sclerosis (TSC) is an autosomal dominant disorder caused by a mutation in either the TSC1 or TSC2 tumour suppressor genes. The disease is characterised by hamartomas in one or more organs (including brain, skin, heart and kidney) giving rise to a broad phenotypic spectrum (including seizures, mental retardatio...

[ "GO:0005096", "GO:0032007", "GO:0043547", "GO:0033596" ]

[ "GTPase activator activity", "negative regulation of TOR signaling", "positive regulation of GTPase activity", "TSC1-TSC2 complex" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PRINTS" ]

[ "PR01431" ]

[ "TUBERIN" ]

[ 2942 ]

1

[ "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "GenProp2033", "R-HSA-1632852", "R-HSA-165181", "R-HSA-198323", "R-HSA-380972", "R-HSA-5628897", "R-HSA-5674400", "R-HSA-8854214", "R-MMU-1632852", "R-MMU-165181", "R-MMU-198323", "R-MMU-380972", "R-MMU-5628897", "R-MMU-8854214", "R-RNO-1632852", "R-RNO-165181", "R-RNO-198323", "R-...

[ "GP:GenProp2033", "REACTOME:R-HSA-1632852", "REACTOME:R-HSA-165181", "REACTOME:R-HSA-198323", "REACTOME:R-HSA-380972", "REACTOME:R-HSA-5628897", "REACTOME:R-HSA-5674400", "REACTOME:R-HSA-8854214", "REACTOME:R-MMU-1632852", "REACTOME:R-MMU-165181", "REACTOME:R-MMU-198323", "REACTOME:R-MMU-38097...

20

[ "7dl2", "9ce3" ]

2

[ "PUB00007617", "PUB00007618", "PUB00007619", "PUB00062931", "PUB00062932" ]

[ "9580671", "7558029", "9045618", "15340059", "12271141" ]

[ "Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products.", "Alternative splicing of the tuberous sclerosis 2 (TSC2) gene in human and mouse tissues.", "The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis.", "Biochemic...

[ 1998, 1995, 1997, 2004, 2002 ]

5

[ "IPR027107" ]

[]

1

0

1

[ "Deferribacter", "Eukaryota" ]

[ 2, 2940 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 8, 34, 12, 7 ]

5

true

Family

Tuberin

6

IPR003914

3,914

Rabaptin

Family

3,596

false

Rabaptins interact with the GTP form of the small GTPase Rab5, a potent regulator of endocytic transport [ ]. Two rabaptins have been identified, rabaptin-5 and rabaptin-5beta. Both proteins bind to Rab5 and cooperate in endocytic membrane fusion [ ].

[ "GO:0005096", "GO:0006897" ]

[ "GTPase activator activity", "endocytosis" ]

[ "molecular_function", "biological_process" ]

2

[ "PRINTS", "PANTHER" ]

[ "PR01432", "PTHR31179" ]

[ "RABAPTIN", "" ]

[ 1896, 3587 ]

2

[ "REACTOME" ]

[ "R-HSA-8854214" ]

[ "REACTOME:R-HSA-8854214" ]

1

[ "1tu3", "1x79", "4n3y", "4n3z", "4q9u" ]

5

[ "PUB00007621", "PUB00071213" ]

[ "8521472", "9524116" ]

[ "Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion.", "Two distinct effectors of the small GTPase Rab5 cooperate in endocytic membrane fusion." ]

[ 1995, 1998 ]

2

[]

0

null

[ "Eukaryota", "Funiculus sociatus GB2-A5" ]

[ 3595, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 4, 1, 15, 7, 20 ]

6

true

Family

Rabaptin

6

IPR003915

3,915

Polycystic kidney disease type 2 protein

PKD_2

Family

7,909

false

Polycystic kidney diseases (PKD) are disorders characterised by large numbers of cysts distributed throughout grossly-enlarged kidneys. Cyst development is associated with impairment of kidney function, and ultimately kidney failure and death [ , ]. Most cases of autosomal dominant PKD result from mutations in the PKD1...

[ "GO:0005509", "GO:0016020" ]

[ "calcium ion binding", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PRINTS" ]

[ "PR01433" ]

[ "POLYCYSTIN2" ]

[ 7909 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5620916", "R-CEL-5620916", "R-DRE-5620916", "R-HSA-5620916", "R-MMU-5620916" ]

[ "REACTOME:R-BTA-5620916", "REACTOME:R-CEL-5620916", "REACTOME:R-DRE-5620916", "REACTOME:R-HSA-5620916", "REACTOME:R-MMU-5620916" ]

5

[ "4dxw", "5k47", "5mke", "5mkf", "5t4d", "5z1w", "6a70", "6d1w", "6du8", "6t9n", "6t9o", "6wb8", "7d7e", "7d7f", "8hk7", "8k3s", "8z6b", "8z6f", "8z6h", "8zkh", "8zkr", "8zks", "8zkt", "8zku", "9dli", "9dwq" ]

26

[ "PUB00004881", "PUB00007622", "PUB00007623", "PUB00099174" ]

[ "8643665", "8650545", "9326320", "29567962" ]

[ "Polycystin, the polycystic kidney disease 1 protein, is expressed by epithelial cells in fetal, adult, and polycystic kidney.", "PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein.", "A spectrum of mutations in the second gene for autosomal dominant polycystic kidney disease (...

[ 1996, 1996, 1997, 2018 ]

4

[]

0

null

[ "Bacteria", "Candidatus Nitrosocosmicus", "Eukaryota", "ecological metagenomes" ]

[ 278, 2, 7622, 7 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 22, 8, 11, 12, 11 ]

6

true

Family

Polycystic kidney disease type 2 protein

PKD_2

7

IPR003917

3,917

NADH:ubiquinone oxidoreductase, chain 2

NADH_UbQ_OxRdtase_chain2

Family

88,880

false

This entry represents subunit 2 (ND2 or chain 2) from NADH:ubiquinone oxidoreductase (complex I). Defects in the ND2 gene are one of the causes of Leber's hereditary optic neuropathy, a maternally inherited disease resulting in acute bilateral blindness due to retinal degeneration, predominantly in young men [ , ]. Car...

[ "GO:0008137", "GO:0006120" ]

[ "NADH dehydrogenase (ubiquinone) activity", "mitochondrial electron transport, NADH to ubiquinone" ]

[ "molecular_function", "biological_process" ]

2

[ "PRINTS" ]

[ "PR01436" ]

[ "NADHDHGNASE2" ]

[ 88880 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REA...

[ "7.1.1.2", "PWY-3781", "PWY-4302", "PWY-5083", "PWY-6692", "R-DME-5419276", "R-DME-611105", "R-DME-6799198", "R-DRE-611105", "R-GGA-5419276", "R-GGA-611105", "R-GGA-6799198", "R-HSA-5419276", "R-HSA-611105", "R-HSA-6799198", "R-HSA-9837999", "R-MMU-5419276", "R-MMU-611105", "R-MM...

[ "EC:7.1.1.2", "METACYC:PWY-3781", "METACYC:PWY-4302", "METACYC:PWY-5083", "METACYC:PWY-6692", "REACTOME:R-DME-5419276", "REACTOME:R-DME-611105", "REACTOME:R-DME-6799198", "REACTOME:R-DRE-611105", "REACTOME:R-GGA-5419276", "REACTOME:R-GGA-611105", "REACTOME:R-GGA-6799198", "REACTOME:R-HSA-541...

25

[ "5gpn", "5gup", "5lc5", "5ldw", "5ldx", "5lnk", "5o31", "5xtc", "5xtd", "5xth", "5xti", "6g2j", "6g72", "6q9b", "6qa9", "6qbx", "6qc2", "6qc3", "6qc4", "6qc5", "6qc6", "6qc7", "6qc8", "6qc9", "6qca", "6qcf", "6zka", "6zkb", "6zkc", "6zkd", "6zke", "6zkf"...

209

[ "PUB00005074", "PUB00008815", "PUB00008816", "PUB00008817", "PUB00008824", "PUB00043561", "PUB00045437" ]

[ "1470679", "1900003", "1732158", "3201231", "1370613", "10940377", "18394423" ]

[ "The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains.", "Alternative, simultaneous complex I mitochondrial DNA mutations in Leber's hereditary optic neuropathy.", "Mitochondrial DNA complex I and III mutations associated with Leber's hereditary optic neuropathy.", "Mitochondrial DNA mutation ...

[ 1992, 1991, 1992, 1988, 1992, 2000, 2008 ]

7

[]

0

null

[ "Bacteria", "Eukaryota", "marine sediment metagenome" ]

[ 64, 88815, 1 ]

3

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 13, 984, 24, 11 ]

5

true

Family

NADH:ubiquinone oxidoreductase, chain 2

NADH_UbQ_OxRdtase_chain2

9

IPR003918

3,918

NADH:ubiquinone oxidoreductase

NADH_UbQ_OxRdtase

Family

111,581

false

This entry contains members of the subunit families 4, 2 and 5 from complex I.

[ "GO:0008137", "GO:0042773" ]

[ "NADH dehydrogenase (ubiquinone) activity", "ATP synthesis coupled electron transport" ]

[ "molecular_function", "biological_process" ]

2

[ "PRINTS", "PANTHER" ]

[ "PR01437", "PTHR43507" ]

[ "NUOXDRDTASE4", "" ]

[ 100782, 94681 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "7.1.1", "R-BTA-5419276", "R-BTA-611105", "R-BTA-6799198", "R-CEL-5419276", "R-DME-5419276", "R-DME-611105", "R-DME-6799198", "R-DRE-611105", "R-GGA-5419276", "R-GGA-611105", "R-GGA-6799198", "R-HSA-5419276", "R-HSA-611105", "R-HSA-6799198", "R-MMU-5419276", "R-MMU-611105", "R-MMU-...

[ "EC:7.1.1", "REACTOME:R-BTA-5419276", "REACTOME:R-BTA-611105", "REACTOME:R-BTA-6799198", "REACTOME:R-CEL-5419276", "REACTOME:R-DME-5419276", "REACTOME:R-DME-611105", "REACTOME:R-DME-6799198", "REACTOME:R-DRE-611105", "REACTOME:R-GGA-5419276", "REACTOME:R-GGA-611105", "REACTOME:R-GGA-6799198", ...

24

[ "3rko", "4he8", "4hea", "4wz7", "5gpn", "5gup", "5lc5", "5ldw", "5ldx", "5lnk", "5o31", "5xtc", "5xtd", "5xth", "5xti", "6g2j", "6g72", "6gcs", "6h8k", "6hum", "6i0d", "6i1p", "6khi", "6khj", "6l7o", "6l7p", "6nbq", "6nbx", "6nby", "6q8o", "6q8w", "6q8x"...

318

[ "PUB00005074", "PUB00043561", "PUB00045437" ]

[ "1470679", "10940377", "18394423" ]

[ "The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains.", "The respiratory complex I of bacteria, archaea and eukarya and its module common with membrane-bound multisubunit hydrogenases.", "Assembly of the Escherichia coli NADH:ubiquinone oxidoreductase (complex I)." ]

[ 1992, 2000, 2008 ]

3

[]

[ "IPR004775", "IPR010227" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1591, 36696, 72361, 933 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 17, 3, 1, 38, 3, 708, 12, 2, 8, 10, 3 ]

11

true

Family

NADH:ubiquinone oxidoreductase

NADH_UbQ_OxRdtase

5

IPR003919

3,919

Cellulose synthase, subunit A

Cell_synth_A

Family

5,171

false

An operon encoding 4 proteins required for bacterial cellulose biosynthesis (bcs) in Acetobacter xylinus (Gluconacetobacter xylinus) has been isolated via genetic complementation with strains lacking cellulose synthase activity [ ]. Nucleotide sequence analysis showed the cellulose synthase operon to consist of 4 genes...

[ "GO:0016759", "GO:0035438", "GO:0006011", "GO:0016020" ]

[ "cellulose synthase activity", "cyclic-di-GMP binding", "UDP-alpha-D-glucose metabolic process", "membrane" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PRINTS", "NCBIFAM" ]

[ "PR01439", "TIGR03030" ]

[ "CELLSNTHASEA", "CelA" ]

[ 5088, 3985 ]

2

[ "CAZY", "EC", "GP", "METACYC", "REACTOME" ]

[ "GT2", "2.4.1.12", "GenProp0658", "PWY-1001", "R-HSA-9931953" ]

[ "CAZY:GT2", "EC:2.4.1.12", "GP:GenProp0658", "METACYC:PWY-1001", "REACTOME:R-HSA-9931953" ]

5

[ "4hg6", "4p00", "4p02", "5eiy", "5ej1", "5ejz", "7lby", "9b8v", "9fmv", "9fmz", "9fnn", "9fp0" ]

12

[ "PUB00007624", "PUB00007625", "PUB00049330", "PUB00055000" ]

[ "2146681", "2151718", "18034161", "16920715" ]

[ "Genetic organization of the cellulose synthase operon in Acetobacter xylinum.", "Cloning and sequencing of the cellulose synthase catalytic subunit gene of Acetobacter xylinum.", "The structural basis of cyclic diguanylate signal transduction by PilZ domains.", "The PilZ domain is a receptor for the second m...

[ 1990, 1990, 2007, 2006 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Synechococcus phage S-CBWM1", "metagenomes" ]

[ 7, 5133, 13, 1, 17 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Cellulose synthase, subunit A

Cell_synth_A

7

IPR003920

3,920

Cellulose synthase, subunit B

Cell_synth_B

Family

3,336

false

An operon encoding 4 proteins required for bacterial cellulose biosynthesis (bcs) in Acetobacter xylinus (Gluconacetobacter xylinus) has been isolated via genetic complementation with strains lacking cellulose synthase activity [ ]. Nucleotide sequence analysis showed the cellulose synthase operon to consist of 4 genes...

[ "GO:0006011", "GO:0016020" ]

[ "UDP-alpha-D-glucose metabolic process", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PRINTS" ]

[ "PR01440" ]

[ "CELLSNTHASEB" ]

[ 3336 ]

1

[ "REACTOME" ]

[ "R-HSA-9931953" ]

[ "REACTOME:R-HSA-9931953" ]

1

[ "6yg8", "7l2z", "7lby", "9b8i", "9b8v", "9fmt", "9fmv", "9fmz", "9fnn", "9fp0" ]

10

[ "PUB00007624" ]

[ "2146681" ]

[ "Genetic organization of the cellulose synthase operon in Acetobacter xylinum." ]

[ 1990 ]

1

[ "IPR018513" ]

[]

1

0

1

[ "Opisthokonta", "Pseudomonadati", "metagenomes" ]

[ 7, 3298, 31 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Cellulose synthase, subunit B

Cell_synth_B

7

IPR003921

3,921

Cellulose synthase, subunit C

Cell_synth_C

Family

1,766

false

An operon encoding 4 proteins required for bacterial cellulose biosynthesis (bcs) in Acetobacter xylinus (Gluconacetobacter xylinus) has been isolated via genetic complementation with strains lacking cellulose synthase activity [ ]. Nucleotide sequence analysis showed the cellulose synthase operon to consist of 4 genes...

[ "GO:0006011", "GO:0016020" ]

[ "UDP-alpha-D-glucose metabolic process", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PRINTS" ]

[ "PR01441" ]

[ "CELLSNTHASEC" ]

[ 1766 ]

1

[]

0

[]

0

[ "PUB00007624" ]

[ "2146681" ]

[ "Genetic organization of the cellulose synthase operon in Acetobacter xylinum." ]

[ 1990 ]

1

[]

0

null

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 1754, 3, 9 ]

3

[]

0

true

Family

Cellulose synthase, subunit C

Cell_synth_C

1

IPR003923

3,923

Transcription initiation factor TFIID, subunit 10

TAF10

Family

4,309

false

Transcription initiation factor TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. The complex includes TATA binding protein (TBP) and various TBP-associated factors (TAFS). TFIID is a bona fide RNA polymerase II-specific TATA-binding pr...

[ "GO:0006352", "GO:0005634" ]

[ "DNA-templated transcription initiation", "nucleus" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PIRSF", "PRINTS", "PANTHER", "CDD" ]

[ "PF03540", "PIRSF017246", "PR01443", "PTHR21242", "cd07982" ]

[ "TAF10", "TFIID_TAF10", "TFIID30KDSUB", "", "HFD_TAF10" ]

[ 4303, 2497, 3061, 4074, 3986 ]

5

[ "GP", "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "GenProp2052", "GenProp2054", "GenProp2057", "R-CEL-674695", "R-CEL-73776", "R-CEL-73779", "R-CEL-75953", "R-CEL-76042", "R-DME-5689880", "R-DME-674695", "R-DME-6804756", "R-DME-73776", "R-DME-73779", "R-DME-75953", "R-DME-76042", "R-HSA-167161", "R-HSA-167162", "R-HSA-167172", "...

[ "GP:GenProp2052", "GP:GenProp2054", "GP:GenProp2057", "REACTOME:R-CEL-674695", "REACTOME:R-CEL-73776", "REACTOME:R-CEL-73779", "REACTOME:R-CEL-75953", "REACTOME:R-CEL-76042", "REACTOME:R-DME-5689880", "REACTOME:R-DME-674695", "REACTOME:R-DME-6804756", "REACTOME:R-DME-73776", "REACTOME:R-DME-...

45

[ "4wv4", "6mzc", "6mzd", "6mzl", "6mzm", "6t9i", "6t9k", "6tb4", "6tbm", "7edx", "7eg7", "7eg8", "7eg9", "7ega", "7egb", "7egc", "7egd", "7ege", "7egf", "7egg", "7egi", "7egj", "7ena", "7enc", "7ktr", "7kts", "8gxq", "8gxs", "8h7g", "8wak", "8wal", "8wan"...

37

[ "PUB00007626", "PUB00044510", "PUB00079561", "PUB00079562" ]

[ "8662725", "16858867", "15870280", "17375202" ]

[ "Isolation and characterization of TAF25, an essential yeast gene that encodes an RNA polymerase II-specific TATA-binding protein-associated factor.", "The general transcription machinery and general cofactors.", "The nuclear import of TAF10 is regulated by one of its three histone fold domain-containing intera...

[ 1996, 2006, 2005, 2007 ]

4

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 4308, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 2, 1, 2, 2, 1, 1, 3, 2, 1, 1, 7 ]

12

true

Family

Transcription initiation factor TFIID, subunit 10

TAF10

5

IPR003924

3,924

GPCR, family 2, latrophilin

GPCR_2_latrophilin

Family

9,021

false

Latrophilins are a family of secretin-like GPCRs that can be subdividedinto 3 subtypes: LPH1, LPH2 and LPH3. LPH1 is a brain-specific calcium independent receptor of alpha-latrotoxin (LTX), a neurotoxin. It is the affinity of this form of the receptor for LTX that gives the family its name. LPH2 and LPH3, whilst sharin...

[ "GO:0004930", "GO:0016020" ]

[ "G protein-coupled receptor activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PRINTS" ]

[ "PR01444" ]

[ "LATROPHILIN" ]

[ 9021 ]

1

[]

0

[ "5afb", "5ftt", "5ftu", "6ska", "6vhh", "7sf7", "7wy5", "7wy8", "7wyb", "7x10", "8vti", "9e51" ]

12

[ "PUB00001208", "PUB00004310", "PUB00004961", "PUB00005147", "PUB00005148", "PUB00007627", "PUB00053635", "PUB00063577", "PUB00063578", "PUB00063579", "PUB00063580", "PUB00063816", "PUB00095314" ]

[ "1646711", "1314625", "8170923", "1658940", "1658941", "10025961", "12679517", "8081729", "15914470", "18948278", "16753280", "23020293", "26235031" ]

[ "Molecular cloning and expression of a cDNA encoding the secretin receptor.", "Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide.", "Fingerprinting G-protein-coupled receptors.", "Expression cloning of an adenylate cyclase-coupled calcitonin receptor.", ...

[ 1991, 1992, 1994, 1991, 1991, 1999, 2003, 1994, 2005, 2009, 2006, 2013, 2015 ]

13

[ "IPR000832" ]

[]

1

0

1

[ "Bilateria" ]

[ 9021 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 135, 29, 31, 49 ]

4

true

Family

GPCR, family 2, latrophilin

GPCR_2_latrophilin

9

IPR003925

3,925

Claudin-6

Claudin6

Family

155

false

Claudins form the paracellular tight junction seal in epithelial tissues. In humans, 24 claudins (claudin 1-24) have been identified. Their ability to polymerise and form strands is affected by the cell types [ , , ]. They can also form heteropolymers with each other within and between tight junction strands [ ]. Most ...

[ "GO:0005198", "GO:0005923" ]

[ "structural molecule activity", "bicellular tight junction" ]

[ "molecular_function", "cellular_component" ]

2

[ "PRINTS" ]

[ "PR01445" ]

[ "CLAUDIN6" ]

[ 155 ]

1

[ "REACTOME" ]

[ "R-HSA-420029" ]

[ "REACTOME:R-HSA-420029" ]

1

[]

0

[ "PUB00004927", "PUB00070979", "PUB00070980", "PUB00070981", "PUB00070982" ]

[ "9892664", "24665401", "20188437", "21372174", "10562289" ]

[ "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands.", "Claudin interactions in and out of the tight junction.", "The protoplasmic or exoplasmic face association of tight junction particles cannot predict paracellular permeability or heterotypic claudin comp...

[ 1999, 2013, 2010, 2011, 1999 ]

5

[ "IPR006187" ]

[]

1

0

1

[ "Eutheria" ]

[ 155 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 3 ]

3

true

Family

Claudin-6

Claudin6

3

IPR003927

3,927

Claudin-16

Claudin16

Family

1,059

false

Claudins form the paracellular tight junction seal in epithelial tissues. In humans, 24 claudins (claudin 1-24) have been identified. Their ability to polymerise and form strands is affected by the cell types [ , , ]. They can also form heteropolymers with each other within and between tight junction strands [ ]. Most ...

[ "GO:0005198", "GO:0005923" ]

[ "structural molecule activity", "bicellular tight junction" ]

[ "molecular_function", "cellular_component" ]

2

[ "PRINTS" ]

[ "PR01447" ]

[ "CLAUDIN16" ]

[ 1059 ]

1

[ "REACTOME" ]

[ "R-HSA-420029" ]

[ "REACTOME:R-HSA-420029" ]

1

[]

0

[ "PUB00006694", "PUB00006695", "PUB00070979", "PUB00070980", "PUB00070981", "PUB00070982" ]

[ "10810088", "10390358", "24665401", "20188437", "21372174", "10562289" ]

[ "Null mutation of PCLN-1/Claudin-16 results in bovine chronic interstitial nephritis.", "Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption.", "Claudin interactions in and out of the tight junction.", "The protoplasmic or exoplasmic face association of tight junction partic...

[ 2000, 1999, 2013, 2010, 2011, 1999 ]

6

[ "IPR006187" ]

[]

1

0

1

[ "Vertebrata" ]

[ 1059 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 3 ]

3

true

Family

Claudin-16

Claudin16

1

IPR003928

3,928

Claudin-18

Claudin18

Family

941

false

Claudins form the paracellular tight junction seal in epithelial tissues. In humans, 24 claudins (claudin 1-24) have been identified. Their ability to polymerise and form strands is affected by the cell types [ , , ]. They can also form heteropolymers with each other within and between tight junction strands [ ]. Most ...

[ "GO:0005198", "GO:0005923" ]

[ "structural molecule activity", "bicellular tight junction" ]

[ "molecular_function", "cellular_component" ]

2

[ "PRINTS" ]

[ "PR01448" ]

[ "CLAUDIN18" ]

[ 941 ]

1

[ "REACTOME" ]

[ "R-HSA-420029" ]

[ "REACTOME:R-HSA-420029" ]

1

[]

0

[ "PUB00070979", "PUB00070980", "PUB00070981", "PUB00070982" ]

[ "24665401", "20188437", "21372174", "10562289" ]

[ "Claudin interactions in and out of the tight junction.", "The protoplasmic or exoplasmic face association of tight junction particles cannot predict paracellular permeability or heterotypic claudin compatibility.", "Role of claudin species-specific dynamics in reconstitution and remodeling of the zonula occlud...

[ 2013, 2010, 2011, 1999 ]

4

[ "IPR006187" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 941 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 2, 1 ]

3

true

Family

Claudin-18

Claudin18

8

IPR003929

3,929

Calcium-activated potassium channel BK, alpha subunit

K_chnl_BK_asu

Domain

15,292

false

This entry represents a conserved region found in calcium-activated potassium channels, known as BK channels (also referred to as high-conductance, maxi-K channels) [ ] or Slowpoke homologues (Slo1-3), including calcium-activated potassium channel slowpoke (Slo) from Drosophila and its homologues from vertebrates, name...

[ "GO:0006813", "GO:0016020" ]

[ "potassium ion transport", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF03493" ]

[ "BK_channel_a" ]

[ 15292 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-1296052", "R-CEL-1300642", "R-DME-1300642", "R-GGA-1296052", "R-GGA-1300642", "R-HSA-1296052", "R-HSA-1300642", "R-HSA-418457", "R-HSA-9662360", "R-HSA-9667769", "R-MMU-1296052", "R-MMU-1300642", "R-PFA-1300642", "R-RNO-1296052", "R-RNO-1300642" ]

[ "REACTOME:R-BTA-1296052", "REACTOME:R-CEL-1300642", "REACTOME:R-DME-1300642", "REACTOME:R-GGA-1296052", "REACTOME:R-GGA-1300642", "REACTOME:R-HSA-1296052", "REACTOME:R-HSA-1300642", "REACTOME:R-HSA-418457", "REACTOME:R-HSA-9662360", "REACTOME:R-HSA-9667769", "REACTOME:R-MMU-1296052", "REACTOME...

15

[ "3mt5", "3naf", "3u6n", "4hpf", "5a6e", "5a6f", "5tj6", "5tji", "5u70", "5u76", "6nd0", "6v22", "6v35", "6v38", "6v3g", "6v5a", "7pxe", "7pxf", "7pxg", "7pxh", "7rjt", "7rk6", "7ynz", "7yo0", "7yo1", "7yo2", "7yo3", "7yo4", "7yo5", "8gh9", "8ghf", "8ghg"...

62

[ "PUB00001055", "PUB00001622", "PUB00002771", "PUB00004011", "PUB00004020", "PUB00006577", "PUB00009378", "PUB00083185", "PUB00083186", "PUB00083187", "PUB00151177", "PUB00151178" ]

[ "1772658", "1879548", "1373731", "2448635", "2451788", "2555158", "11178249", "17115074", "26587966", "23129643", "34980136", "31152168" ]

[ "The molecular biology of K+ channels.", "Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.", "Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.", "Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso...

[ 1991, 1991, 1992, 1988, 1988, 1989, 2000, 2006, 2016, 2012, 2022, 2019 ]

12

[]

0

null

[ "Eukaryota" ]

[ 15292 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 21, 107, 18, 78, 58, 28 ]

6

true

Domain

Calcium-activated potassium channel BK, alpha subunit

K_chnl_BK_asu

2

IPR003932

3,932

Epithelial membrane protein EMP-1

EMP_1

Family

209

false

The epithelial membrane proteins (EMP-1, -2 and -3), peripheral myelin protein 22 (PMP22), and lens fibre membrane intrinsic protein (LMIP) comprise a protein family on the basis of sequence and structural similarities [ ]. Each family member is a small hydrophobic membrane glycoprotein, ~160-170 amino acids in length,...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PRINTS" ]

[ "PR01454" ]

[ "EPMEMPROT1" ]

[ 209 ]

1

[]

0

[]

0

[ "PUB00001869", "PUB00002934", "PUB00008831", "PUB00008833" ]

[ "8996089", "7499407", "8884260", "9126480" ]

[ "Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins.", "Epithelial membrane protein-1, peripheral myelin protein 22, and lens membrane protein 20 define a novel gene family.", "Identification and characterization of a cDNA and the structural gene enc...

[ 1996, 1995, 1996, 1997 ]

4

[ "IPR004032" ]

[]

1

0

1

[ "Amniota" ]

[ 209 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 4, 4 ]

3

true

Family

Epithelial membrane protein EMP-1

EMP_1

1

IPR003933

3,933

Epithelial membrane protein 2

EMP-2

Family

699

false

The epithelial membrane proteins (EMP-1, -2 and -3), peripheral myelin protein 22 (PMP22), and lens fibre membrane intrinsic protein (LMIP) comprise a protein family on the basis of sequence and structural similarities [ ]. Each family member is a small hydrophobic membrane glycoprotein, ~160-170 amino acids in length,...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PRINTS" ]

[ "PR01455" ]

[ "EPMEMPROT2" ]

[ 699 ]

1

[]

0

[]

0

[ "PUB00001869", "PUB00002934", "PUB00008831", "PUB00008842" ]

[ "8996089", "7499407", "8884260", "8917086" ]

[ "Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins.", "Epithelial membrane protein-1, peripheral myelin protein 22, and lens membrane protein 20 define a novel gene family.", "Identification and characterization of a cDNA and the structural gene enc...

[ 1996, 1995, 1996, 1996 ]

4

[ "IPR004032" ]

[]

1

0

1

[ "Euteleostomi", "Pusillimonas minor" ]

[ 698, 1 ]

2

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 6, 1 ]

3

true

Family

Epithelial membrane protein 2

EMP-2

7

IPR003934

3,934

Epithelial membrane protein EMP-3

EMP_3

Family

249

false

The epithelial membrane proteins (EMP-1, -2 and -3), peripheral myelin protein 22 (PMP22), and lens fibre membrane intrinsic protein (LMIP) comprise a protein family on the basis of sequence and structural similarities [ ]. Each family member is a small hydrophobic membrane glycoprotein, ~160-170 amino acids in length,...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PRINTS" ]

[ "PR01456" ]

[ "EPMEMPROT3" ]

[ 249 ]

1

[]

0

[]

0

[ "PUB00001869", "PUB00002934", "PUB00008831", "PUB00008842" ]

[ "8996089", "7499407", "8884260", "8917086" ]

[ "Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins.", "Epithelial membrane protein-1, peripheral myelin protein 22, and lens membrane protein 20 define a novel gene family.", "Identification and characterization of a cDNA and the structural gene enc...

[ 1996, 1995, 1996, 1996 ]

4

[ "IPR004032" ]

[]

1

0

1

[ "Euteleostomi" ]

[ 249 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 2, 2 ]

3

true

Family

Epithelial membrane protein EMP-3

EMP_3

1

IPR003935

3,935

Lens fibre membrane intrinsic protein

LMIP

Family

1,236

false

The epithelial membrane proteins (EMP-1, -2 and -3), peripheral myelin protein 22 (PMP22), and lens fibre membrane intrinsic protein (LMIP) comprise a protein family on the basis of sequence and structural similarities [ ]. Each family member is a small hydrophobic membrane glycoprotein, ~160-170 amino acids in length,...

[ "GO:0005212", "GO:0016020" ]

[ "structural constituent of eye lens", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PRINTS" ]

[ "PR01457" ]

[ "LENSMEMPROT" ]

[ 1236 ]

1

[]

0

[ "9cbv" ]

1

[ "PUB00002934", "PUB00008831", "PUB00008853", "PUB00008854", "PUB00008855" ]

[ "7499407", "8884260", "2584203", "1331134", "2584204" ]

[ "Epithelial membrane protein-1, peripheral myelin protein 22, and lens membrane protein 20 define a novel gene family.", "Identification and characterization of a cDNA and the structural gene encoding the mouse epithelial membrane protein-1.", "Identification of an 18,000-dalton protein in mammalian lens fiber ...

[ 1995, 1996, 1989, 1992, 1989 ]

5

[ "IPR004032" ]

[]

1

0

1

[ "Vertebrata" ]

[ 1236 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 12, 4, 3, 2 ]

4

true

Family

Lens fibre membrane intrinsic protein

LMIP

1

IPR003936

3,936

Peripheral myelin protein PMP22

PMP22

Family

390

false

The epithelial membrane proteins (EMP-1, -2 and -3), peripheral myelin protein 22 (PMP22), and lens fibre membrane intrinsic protein (LMIP) comprise a protein family on the basis of sequence and structural similarities [ ]. Each family member is a small hydrophobic membrane glycoprotein, ~160-170 amino acids in length,...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PRINTS" ]

[ "PR01458" ]

[ "PMYELIN22" ]

[ 390 ]

1

[ "REACTOME" ]

[ "R-HSA-9619665" ]

[ "REACTOME:R-HSA-9619665" ]

1

[]

0

[ "PUB00002934", "PUB00008831", "PUB00008858", "PUB00008859", "PUB00008860", "PUB00008862", "PUB00008863" ]

[ "7499407", "8884260", "7680499", "7605070", "8275092", "7720703", "7649472" ]

[ "Epithelial membrane protein-1, peripheral myelin protein 22, and lens membrane protein 20 define a novel gene family.", "Identification and characterization of a cDNA and the structural gene encoding the mouse epithelial membrane protein-1.", "Progress in the molecular understanding of hereditary peripheral ne...

[ 1995, 1996, 1993, 1995, 1993, 1995, 1995 ]

7

[ "IPR004032" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 390 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 8, 2, 3 ]

3

true

Family

Peripheral myelin protein PMP22

PMP22

8

IPR003938

3,938

Potassium channel, voltage-dependent, EAG/ELK/ERG-like

K_chnl_volt-dep_EAG/ELK/ERG

Family

29,162

false

The first EAG K+ channel was identified in Drosophila melanogaster (Fruit fly), following a screening for mutations giving rise to behavioural abnormalities. Disruption of the Eag gene caused an ether-induced, leg-shaking behaviour. Subsequent studies have revealed a conserved multi-gene family of EAG-like K+ channels,...

[ "GO:0005249", "GO:0006813", "GO:0016020" ]

[ "voltage-gated potassium channel activity", "potassium ion transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01463" ]

[ "EAGCHANLFMLY" ]

[ 29162 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-1296072", "R-CEL-2485179", "R-CEL-2514859", "R-CEL-5620916", "R-CFA-1296072", "R-CFA-5576890", "R-DME-1296072", "R-HSA-1296061", "R-HSA-1296072", "R-HSA-5576890", "R-MMU-1296061", "R-MMU-1296072", "R-MMU-5576890", "R-MMU-5620916", "R-RNO-1296061", "R-RNO-1296072", "R-RNO-55768...

[ "REACTOME:R-BTA-1296072", "REACTOME:R-CEL-2485179", "REACTOME:R-CEL-2514859", "REACTOME:R-CEL-5620916", "REACTOME:R-CFA-1296072", "REACTOME:R-CFA-5576890", "REACTOME:R-DME-1296072", "REACTOME:R-HSA-1296061", "REACTOME:R-HSA-1296072", "REACTOME:R-HSA-5576890", "REACTOME:R-MMU-1296061", "REACTOM...

20

[ "5h3o", "5k7l", "5u6o", "5u6p", "5v4s", "5va1", "5va2", "5va3", "6gyn", "6gyo", "6pbx", "6pby", "6ufe", "6uqf", "6uqg", "6v1x", "6v1y", "6wej", "6wek", "6wel", "7cal", "7cn0", "7cn1", "7fcv", "7n15", "7n16", "7n17", "7np3", "7np4", "7t4x", "7wm1", "7wm2"...

93

[ "PUB00001055", "PUB00001622", "PUB00002771", "PUB00004011", "PUB00004020", "PUB00006577", "PUB00007312", "PUB00009378" ]

[ "1772658", "1879548", "1373731", "2448635", "2451788", "2555158", "10798390", "11178249" ]

[ "The molecular biology of K+ channels.", "Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.", "Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.", "Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso...

[ 1991, 1991, 1992, 1988, 1988, 1989, 2000, 2000 ]

8

[]

[ "IPR045319", "IPR050818" ]

0

2

0

[ "Bacteria", "Eukaryota", "Methanobacteriota", "metagenomes" ]

[ 775, 28370, 9, 8 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 76, 14, 86, 25, 41, 29, 43, 49, 72 ]

9

true

Family

Potassium channel, voltage-dependent, EAG/ELK/ERG-like

K_chnl_volt-dep_EAG/ELK/ERG

3

IPR003939

3,939

Transforming growth factor beta-1 proprotein

TGFb1

Family

602

false

The transforming growth factors-beta constitute a family of multi-functional cytokines that regulate cell growth and differentiation [ ]. Many cells synthesise TGF-beta, and essentially all have specific receptors for this peptide [ ]. TGF-beta regulates the actions of many other peptide growth factors and determines a...

[ "GO:0005160" ]

[ "transforming growth factor beta receptor binding" ]

[ "molecular_function" ]

1

[ "PRINTS" ]

[ "PR01424" ]

[ "TGFBETA1" ]

[ 602 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-114608", "R-HSA-168277", "R-HSA-202733", "R-HSA-2129379", "R-HSA-2173788", "R-HSA-2173789", "R-HSA-2173791", "R-HSA-3000170", "R-HSA-3000178", "R-HSA-3304356", "R-HSA-3642279", "R-HSA-3645790", "R-HSA-3656532", "R-HSA-3656535", "R-HSA-381340", "R-HSA-5689603", "R-HSA-6785807",...

[ "REACTOME:R-HSA-114608", "REACTOME:R-HSA-168277", "REACTOME:R-HSA-202733", "REACTOME:R-HSA-2129379", "REACTOME:R-HSA-2173788", "REACTOME:R-HSA-2173789", "REACTOME:R-HSA-2173791", "REACTOME:R-HSA-3000170", "REACTOME:R-HSA-3000178", "REACTOME:R-HSA-3304356", "REACTOME:R-HSA-3642279", "REACTOME:R...

54

[ "5ffo", "5vqf", "5vqp", "6gff", "6p7j", "6uja", "7y1r", "7y1t", "8c7h", "8rew", "8rex", "8udz", "8vsc", "8vsd" ]

14

[ "PUB00005153", "PUB00007611", "PUB00007612", "PUB00007613", "PUB00007614", "PUB00007628" ]

[ "1631557", "8424942", "2879635", "8819159", "8679613", "2628730" ]

[ "Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily.", "Transforming growth factor beta 1: NMR signal assignments of the recombinant protein expressed and isotopically enriched using Chinese hamster ovary cells.", "The transforming growth factor-beta system, a complex pa...

[ 1992, 1993, 1987, 1996, 1996, 1989 ]

6

[ "IPR016319" ]

[]

1

0

1

[ "Bilateria" ]

[ 602 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 16, 2, 3 ]

4

true

Family

Transforming growth factor beta-1 proprotein

TGFb1

2