interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR004551 | 4,551 | Diphthine synthase | Dphthn_synthase | Family | 5,672 | false | false | Diphthine synthase ( ), also known as diphthamide biosynthesis S-adenosylmethionine-dependent methyltransferase, participates in the modification of a specific histidine residue in elongation factor 2 (EF-2) of eukaryotes and archaea to diphthamide. It is required for the methylation step in dipthamide biosynthesis. Th... | [
"GO:0004164",
"GO:0017183"
] | [
"diphthine synthase activity",
"protein histidyl modification to diphthamide"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"PIRSF",
"PANTHER",
"NCBIFAM",
"CDD"
] | [
"MF_01084",
"PIRSF036432",
"PTHR10882",
"TIGR00522",
"cd11647"
] | [
"Diphthine_synth",
"Diphthine_synth",
"",
"dph5",
"DHP5_DphB"
] | [
3944,
4728,
5612,
5344,
5281
] | 5 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.1.1.98",
"PWY-6482",
"R-BTA-5358493",
"R-DDI-5358493",
"R-HSA-5358493",
"R-MMU-5358493",
"R-SCE-5358493",
"R-SPO-5358493"
] | [
"EC:2.1.1.98",
"METACYC:PWY-6482",
"REACTOME:R-BTA-5358493",
"REACTOME:R-DDI-5358493",
"REACTOME:R-HSA-5358493",
"REACTOME:R-MMU-5358493",
"REACTOME:R-SCE-5358493",
"REACTOME:R-SPO-5358493"
] | 8 | [
"1vce",
"1vhv",
"1wde",
"1wng",
"2dek",
"2dsg",
"2dsh",
"2dsi",
"2dv3",
"2dv4",
"2dv5",
"2dv7",
"2dxv",
"2dxw",
"2dxx",
"2e07",
"2e08",
"2e15",
"2e16",
"2e17",
"2e4n",
"2e4r",
"2e7r",
"2e8h",
"2e8q",
"2e8r",
"2e8s",
"2ed3",
"2ed5",
"2eeq",
"2egb",
"2egl"... | 85 | [
"PUB00084383"
] | [
"24739148"
] | [
"Dph7 catalyzes a previously unknown demethylation step in diphthamide biosynthesis."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
939,
39,
4658,
36
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
1,
2,
1,
3,
4,
1,
2,
3,
1,
1,
5
] | 12 | true | Family | Diphthine synthase | Diphthine synthase | Dphthn_synthase | 1 |
IPR004552 | 4,552 | 1-acyl-sn-glycerol-3-phosphate acyltransferase | AGP_acyltrans | Domain | 14,091 | false | false | This domain describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases ( ). Proteins scoring above the trusted cut-off are likely to have the same general activity, which is to convert acyl-CoA and 1-acyl-SN-glycerol 3-p... | [
"GO:0003841",
"GO:0008654",
"GO:0016020"
] | [
"1-acylglycerol-3-phosphate O-acyltransferase activity",
"phospholipid biosynthetic process",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00530"
] | [
"AGP_acyltrn"
] | [
14091
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",... | [
"2.3.1.51",
"PWY-5667",
"PWY-5981",
"PWY-6453",
"PWY-7411",
"PWY-7417",
"PWY-7587",
"PWY-7589",
"PWY-7782",
"PWY-8051",
"PWY-8053",
"PWY-8055",
"R-BTA-1483166",
"R-CEL-1483166",
"R-CEL-6798695",
"R-HSA-1483166",
"R-HSA-163765",
"R-HSA-6798695",
"R-HSA-9841922",
"R-MMU-1483166",... | [
"EC:2.3.1.51",
"METACYC:PWY-5667",
"METACYC:PWY-5981",
"METACYC:PWY-6453",
"METACYC:PWY-7411",
"METACYC:PWY-7417",
"METACYC:PWY-7587",
"METACYC:PWY-7589",
"METACYC:PWY-7782",
"METACYC:PWY-8051",
"METACYC:PWY-8053",
"METACYC:PWY-8055",
"REACTOME:R-BTA-1483166",
"REACTOME:R-CEL-1483166",
"... | 25 | [
"5kym"
] | 1 | [
"PUB00057466",
"PUB00092800",
"PUB00092801"
] | [
"16949372",
"17557823",
"9242711"
] | [
"Acyl-phosphates initiate membrane phospholipid synthesis in Gram-positive pathogens.",
"Coupling of fatty acid and phospholipid synthesis in Bacillus subtilis.",
"Human lysophosphatidic acid acyltransferase. cDNA cloning, expression, and localization to chromosome 9q34.3."
] | [
2006,
2007,
1997
] | 3 | [
"IPR002123"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"metagenomes",
"unclassified Candidatus Thermoprofundales"
] | [
8711,
5271,
102,
7
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
4,
2,
1,
3,
1,
6,
7,
1,
3,
7,
1,
1
] | 12 | true | Domain | 1-acyl-sn-glycerol-3-phosphate acyltransferase | 1-acyl-sn-glycerol-3-phosphate acyltransferase | AGP_acyltrans | 8 |
IPR004553 | 4,553 | Hydroxymethylglutaryl-CoA reductase, bacterial-type | HMG_CoA_Rdtase_bac-typ | Family | 4,678 | false | false | There are two distinct classes of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase enzymes: class I consists of eukaryotic and most archaeal enzymes ( ), while class II consists of prokaryotic enzymes ( ) [ , ]. Class I HMG-CoA reductases catalyse the NADP-dependent synthesis of mevalonate from 3-hydroxy-3-methylgl... | [
"GO:0016616",
"GO:0015936"
] | [
"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor",
"coenzyme A metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM",
"CDD"
] | [
"TIGR00532",
"cd00644"
] | [
"HMG_CoA_R_NAD",
"HMG-CoA_reductase_classII"
] | [
4538,
4472
] | 2 | [
"GP"
] | [
"GenProp0047"
] | [
"GP:GenProp0047"
] | 1 | [
"1qax",
"1qay",
"1r31",
"1r7i",
"1t02",
"3qae",
"3qau",
"4i4b",
"4i56",
"4i64",
"4i6a",
"4i6w",
"4i6y",
"5wpj",
"5wpk",
"6dio",
"6eeu",
"6eev",
"6p7k",
"7m1z",
"7m3h",
"7m66",
"7n7s",
"8gdn",
"8sz6",
"8vlq"
] | 26 | [
"PUB00013773",
"PUB00019711",
"PUB00036052",
"PUB00036053",
"PUB00036054",
"PUB00036055"
] | [
"10894743",
"15535874",
"10068515",
"10600463",
"15028676",
"11420376"
] | [
"Identification, evolution, and essentiality of the mevalonate pathway for isopentenyl diphosphate biosynthesis in gram-positive cocci.",
"The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases.",
"Sequence comparisons reveal two classes of 3-hydroxy-3-methylglutaryl coenzyme A reductase.",
"Expressio... | [
2000,
2004,
1999,
1999,
2004,
2001
] | 6 | [
"IPR002202"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
247,
4220,
150,
61
] | 4 | [] | [] | 0 | true | Family | Hydroxymethylglutaryl-CoA reductase, bacterial-type | Hydroxymethylglutaryl-CoA reductase, bacterial-type | HMG_CoA_Rdtase_bac-typ | 7 |
IPR004554 | 4,554 | Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type | HMG_CoA_Rdtase_eu_arc | Family | 8,516 | false | false | This entry represents class I HMG-CoA reductase enzymes. There are two distinct classes of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase enzymes: class I consists of eukaryotic and most archaeal enzymes ( ), while class II consists of prokaryotic enzymes ( ) [ , ]. Class I HMG-CoA reductases catalyse the NADP-de... | [
"GO:0004420",
"GO:0005515",
"GO:0008299"
] | [
"hydroxymethylglutaryl-CoA reductase (NADPH) activity",
"protein binding",
"isoprenoid biosynthetic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"NCBIFAM",
"CDD"
] | [
"TIGR00533",
"cd00643"
] | [
"HMG_CoA_R_NADP",
"HMG-CoA_reductase_classI"
] | [
6709,
8516
] | 2 | [
"EC",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.1.1.34",
"GenProp0047",
"GenProp1432",
"PWY-6174",
"PWY-7391",
"PWY-7524",
"PWY-8125",
"PWY-922",
"R-BTA-191273",
"R-DDI-191273",
"R-DME-191273",
"R-HSA-191273",
"R-HSA-1989781",
"R-HSA-2426168",
"R-HSA-9619665",
"R-MMU-191273",
"R-RNO-191273",
"R-SCE-191273",
"R-SPO-191273"
] | [
"EC:1.1.1.34",
"GP:GenProp0047",
"GP:GenProp1432",
"METACYC:PWY-6174",
"METACYC:PWY-7391",
"METACYC:PWY-7524",
"METACYC:PWY-8125",
"METACYC:PWY-922",
"REACTOME:R-BTA-191273",
"REACTOME:R-DDI-191273",
"REACTOME:R-DME-191273",
"REACTOME:R-HSA-191273",
"REACTOME:R-HSA-1989781",
"REACTOME:R-HS... | 19 | [
"1dq8",
"1dq9",
"1dqa",
"1hw8",
"1hw9",
"1hwi",
"1hwj",
"1hwk",
"1hwl",
"2q1l",
"2q6b",
"2q6c",
"2r4f",
"3bgl",
"3cct",
"3ccw",
"3ccz",
"3cd0",
"3cd5",
"3cd7",
"3cda",
"3cdb",
"6hr7",
"6hr8",
"7uli",
"8ecg",
"8pkn",
"8s6b"
] | 28 | [
"PUB00019711",
"PUB00036052",
"PUB00036053",
"PUB00036054"
] | [
"15535874",
"10068515",
"10600463",
"15028676"
] | [
"The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases.",
"Sequence comparisons reveal two classes of 3-hydroxy-3-methylglutaryl coenzyme A reductase.",
"Expression and characterization of the HMG-CoA reductase of the thermophilic archaeon Sulfolobus solfataricus.",
"Class II 3-hydroxy-3-methylglutar... | [
2004,
1999,
1999,
2004
] | 4 | [
"IPR002202"
] | [
"IPR004816"
] | 1 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified Marseilleviridae",
"unclassified sequences"
] | [
688,
982,
6825,
2,
19
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
7,
3,
5,
4,
1,
10,
7,
2,
1,
18
] | 12 | true | Family | Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type | Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type | HMG_CoA_Rdtase_eu_arc | 5 |
IPR004555 | 4,555 | Glucose-6-phosphate dehydrogenase assembly protein OpcA | G6PDH_assembly_OpcA | Family | 5,475 | false | false | OpcA protein may play a role in the functional assembly of glucose-6-phosphate dehydrogenase [ ]. The opcA gene is found immediately downstream of zwf, the glucose-6-phosphate dehydrogenase (G6PDH) gene, in a number of species, including Mycobacterium tuberculosis, Streptomyces coelicolor, Nostoc punctiforme (strain AT... | [] | [] | [] | 0 | [
"PANTHER",
"NCBIFAM"
] | [
"PTHR38658",
"TIGR00534"
] | [
"",
"OpcA"
] | [
5474,
2657
] | 2 | [] | [] | [] | 0 | [
"9emm"
] | 1 | [
"PUB00017447"
] | [
"9639925"
] | [
"Multiple oligomeric forms of glucose-6-phosphate dehydrogenase in cyanobacteria and the role of OpcA in the assembly process."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
5426,
49
] | 2 | [] | [] | 0 | true | Family | Glucose-6-phosphate dehydrogenase assembly protein OpcA | Glucose-6-phosphate dehydrogenase assembly protein OpcA | G6PDH_assembly_OpcA | 9 |
IPR004556 | 4,556 | Methyltransferase HemK-like | HemK-like | Family | 38,485 | false | false | This entry includes HemK (also known as PrmC) from Escherichia coli. HemK methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif [ , ]. Its homologue in Saccharomyces cerevisiae, Mtq1, is a methyltransferase that methylates MR... | [
"GO:0008276",
"GO:0006479"
] | [
"protein methyltransferase activity",
"protein methylation"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00536"
] | [
"hemK_fam"
] | [
38485
] | 1 | [
"EC",
"EC",
"GP"
] | [
"2.1.1",
"2.1.1.297",
"GenProp0746"
] | [
"EC:2.1.1",
"EC:2.1.1.297",
"GP:GenProp0746"
] | 3 | [
"1nv8",
"1nv9",
"1sg9",
"1t43",
"1vq1",
"2b3t",
"4dzr"
] | 7 | [
"PUB00039505",
"PUB00043100",
"PUB00063062"
] | [
"16364916",
"11847124",
"16321977"
] | [
"Molecular basis for bacterial class I release factor methylation by PrmC.",
"The hemK gene in Escherichia coli encodes the N(5)-glutamine methyltransferase that modifies peptide release factors.",
"The yeast translation release factors Mrf1p and Sup45p (eRF1) are methylated, respectively, by the methyltransfer... | [
2005,
2002,
2006
] | 3 | [] | [
"IPR017127",
"IPR019874",
"IPR022446",
"IPR052663"
] | 0 | 4 | 0 | [
"Bacteria",
"Eukaryota",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
34876,
2974,
2,
633
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
... | [
6,
1,
11,
2,
3,
1,
3,
2,
1,
1,
2
] | 11 | true | Family | Methyltransferase HemK-like | Methyltransferase HemK-like | HemK-like | 6 |
IPR004557 | 4,557 | Eukaryotic/archaeal PrmC-related | PrmC-related | Family | 4,776 | false | false | These proteins exhibit homology to the Saccharomyces cerevisiae Mtq2 (also know as PrmC [ ]). Mtq2 methylates eRF1 on 'Gln-182' using S-adenosyl L-methionine as methyl donor. eRF1 needs to be complexed to eRF3 in its GTP-bound form to be efficiently methylated [ , , ]. In bacteria, the methylation of RF1/RF2 by PrmC is... | [
"GO:0008168"
] | [
"methyltransferase activity"
] | [
"molecular_function"
] | 1 | [
"NCBIFAM"
] | [
"TIGR00537"
] | [
"hemK_rel_arch"
] | [
4776
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.1.1.297",
"R-HSA-156581",
"R-HSA-72764",
"R-MMU-156581",
"R-MMU-72764",
"R-SCE-156581",
"R-SCE-72764"
] | [
"EC:2.1.1.297",
"REACTOME:R-HSA-156581",
"REACTOME:R-HSA-72764",
"REACTOME:R-MMU-156581",
"REACTOME:R-MMU-72764",
"REACTOME:R-SCE-156581",
"REACTOME:R-SCE-72764"
] | 7 | [
"6h1d",
"6h1e",
"6k0x",
"6khs",
"6kmr",
"6kms",
"6ped",
"8cnc",
"8qdg",
"8qdi",
"9fim",
"9fke",
"9fkg",
"9fkm",
"9fkv",
"9fkw",
"9fl4",
"9fl5"
] | 18 | [
"PUB00041889",
"PUB00063061",
"PUB00063062",
"PUB00090823",
"PUB00090976",
"PUB00093695",
"PUB00093696"
] | [
"17008308",
"15509572",
"16321977",
"30010922",
"30017583",
"9826500",
"17932046"
] | [
"The zinc finger protein Ynr046w is plurifunctional and a component of the eRF1 methyltransferase in yeast.",
"The glutamine residue of the conserved GGQ motif in Saccharomyces cerevisiae release factor eRF1 is methylated by the product of the YDR140w gene.",
"The yeast translation release factors Mrf1p and Sup... | [
2006,
2005,
2006,
2018,
2018,
1998,
2007
] | 7 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
825,
1610,
2310,
31
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
4,
1,
2,
1,
1,
2,
2,
2,
1
] | 9 | true | Family | Eukaryotic/archaeal PrmC-related | Eukaryotic/archaeal PrmC-related | PrmC-related | 5 |
IPR004558 | 4,558 | Oxygen-independent coproporphyrinogen III oxidase HemN | Coprogen_oxidase_HemN | Family | 12,017 | false | false | This family represents HemN, the oxygen-independent coproporphyrinogen III oxidase that replaces HemF function under anaerobic conditions. HemN catalyses the anaerobic transformation of coproporhyrinogen-III into protoporphyrinogen-IX during porphyrin biosynthesis. Several species, including Escherichia coli, Helicobac... | [
"GO:0004109",
"GO:0006779",
"GO:0005737"
] | [
"coproporphyrinogen oxidase activity",
"porphyrin-containing compound biosynthetic process",
"cytoplasm"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PIRSF",
"SFLD",
"NCBIFAM"
] | [
"PIRSF000167",
"SFLDF00277",
"TIGR00538"
] | [
"HemN",
"oxygen-independent_coproporphy",
"hemN"
] | [
11829,
3856,
11829
] | 3 | [
"EC",
"GP",
"GP",
"METACYC"
] | [
"1.3.98.3",
"GenProp0221",
"GenProp1686",
"PWY-5531"
] | [
"EC:1.3.98.3",
"GP:GenProp0221",
"GP:GenProp1686",
"METACYC:PWY-5531"
] | 4 | [
"1olt"
] | 1 | [] | [] | [] | [] | 0 | [
"IPR034505"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
11902,
10,
105
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Oxygen-independent coproporphyrinogen III oxidase HemN | Oxygen-independent coproporphyrinogen III oxidase HemN | Coprogen_oxidase_HemN | 3 |
IPR004559 | 4,559 | Heme chaperone HemW-like | HemW-like | Family | 26,298 | false | false | Proteins in this entry include HemW (also known as oxygen-independent coproporphyrinogen-III oxidase-like protein). HemW is a heme chaperone catalyzing the insertion of heme into hemoproteins [ ]. Experimentally determined examples of oxygen-independent coproporphyrinogen III oxidase, an enzyme that replaces HemF funct... | [
"GO:0004109",
"GO:0051539",
"GO:0006779",
"GO:0005737"
] | [
"coproporphyrinogen oxidase activity",
"4 iron, 4 sulfur cluster binding",
"porphyrin-containing compound biosynthetic process",
"cytoplasm"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"SFLD",
"NCBIFAM"
] | [
"SFLDF00562",
"TIGR00539"
] | [
"HemN-like__clustered_with_heat",
"hemN_rel"
] | [
25460,
26065
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00092698"
] | [
"29282292"
] | [
"The radical SAM protein HemW is a heme chaperone."
] | [
2018
] | 1 | [
"IPR034505"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Candidatus Iainarchaeum sp.",
"Eukaryota",
"unclassified sequences"
] | [
24395,
2,
1484,
417
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
3,
1,
1,
1,
1,
2,
3,
4
] | 8 | true | Family | Heme chaperone HemW-like | Heme chaperone HemW-like | HemW-like | 4 |
IPR004560 | 4,560 | L-ribulose-5-phosphate 3-epimerase | L-Ru-5P_3-Epase | Family | 3,197 | false | false | This entry represents the L-ribulose-5-phosphate 3-epimerase UlaE and SgbU from Escherichia coli and other bacterial species. L-ribulose-5-phosphate 3-epimerase ( ) is involved in isomerisation of L-xylulose-5-phosphate to L-ribulose-5-phosphate. Along with UlaD and UlaF, UlaE is involved in a pathway leading to fermen... | [
"GO:0016861",
"GO:0005975"
] | [
"intramolecular oxidoreductase activity, interconverting aldoses and ketoses",
"carbohydrate metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00542"
] | [
"hxl6Piso_put"
] | [
3197
] | 1 | [
"EC",
"METACYC"
] | [
"5.1.3.22",
"PWY-6961"
] | [
"EC:5.1.3.22",
"METACYC:PWY-6961"
] | 2 | [
"3cqh",
"3cqi",
"3cqj",
"3cqk"
] | 4 | [
"PUB00051092"
] | [
"18849419"
] | [
"Structure of L-xylulose-5-Phosphate 3-epimerase (UlaE) from the anaerobic L-ascorbate utilization pathway of Escherichia coli: identification of a novel phosphate binding motif within a TIM barrel fold."
] | [
2008
] | 1 | [] | [
"IPR023492"
] | 0 | 1 | 0 | [
"Bacteria",
"Trichuris trichiura",
"metagenomes"
] | [
3192,
1,
4
] | 3 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | L-ribulose-5-phosphate 3-epimerase | L-ribulose-5-phosphate 3-epimerase | L-Ru-5P_3-Epase | 2 |
IPR004561 | 4,561 | Isochorismate synthase | IsoChor_synthase | Family | 13,344 | false | false | Isochorismate synthase ( ) catalyses the conversion of chorismate to isochorismate, the first step in the biosynthesis of both the respiratory chain component menaquinone (MK, vitamin K2) and phylloquinone (vitamin K1). In bacteria, isochorismate is a precursor of siderophores enterobactin (via the 2,3-dihydroxybenzoat... | [
"GO:0008909",
"GO:0009058"
] | [
"isochorismate synthase activity",
"biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00543"
] | [
"isochor_syn"
] | [
13344
] | 1 | [
"EC",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"5.4.4.2",
"GenProp0058",
"GenProp1058",
"GenProp1243",
"GenProp1291",
"GenProp1336",
"GenProp1560",
"PWY-5837",
"PWY-5901",
"PWY-6406",
"PWY-8321"
] | [
"EC:5.4.4.2",
"GP:GenProp0058",
"GP:GenProp1058",
"GP:GenProp1243",
"GP:GenProp1291",
"GP:GenProp1336",
"GP:GenProp1560",
"METACYC:PWY-5837",
"METACYC:PWY-5901",
"METACYC:PWY-6406",
"METACYC:PWY-8321"
] | 11 | [
"2eua",
"3bzm",
"3bzn",
"3gse",
"3hwo",
"3os6",
"5jxz",
"5jy4",
"5jy8",
"5jzd",
"8w6v",
"8w71"
] | 12 | [
"PUB00011071",
"PUB00014355",
"PUB00014408",
"PUB00014410",
"PUB00014421",
"PUB00014431",
"PUB00014433",
"PUB00014434",
"PUB00014438",
"PUB00014456"
] | [
"7500944",
"11779629",
"10678827",
"8549818",
"10449718",
"2139795",
"1830579",
"8550523",
"11734859",
"8764478"
] | [
"Structural genes for salicylate biosynthesis from chorismate in Pseudomonas aeruginosa.",
"Clustering of isochorismate synthase genes menF and entC and channeling of isochorismate in Escherichia coli.",
"Self-assembling amphiphilic siderophores from marine bacteria.",
"An isochorismate hydroxymutase isogene ... | [
1995,
2001,
2000,
1996,
1999,
1990,
1991,
1996,
2001,
1996
] | 10 | [] | [
"IPR034681"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Halobacteriales",
"metagenomes"
] | [
12051,
726,
328,
239
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
10,
2,
2,
3
] | 4 | true | Family | Isochorismate synthase | Isochorismate synthase | IsoChor_synthase | 4 |
IPR004563 | 4,563 | Apolipoprotein N-acyltransferase | Apolipo_AcylTrfase | Family | 21,211 | false | false | Apolipoprotein N-acyltransferase (Lnt) transfers the acyl group to lipoproteins and is involved in lipoprotein biosynthesis in Gram-negative bacteria. It is an integral membrane protein [ ]. In the last step of lipoprotein maturation, N-acylation by apolipoprotein N-acyltransferase of the plasma membrane is required fo... | [
"GO:0016410",
"GO:0042158",
"GO:0016020"
] | [
"N-acyltransferase activity",
"lipoprotein biosynthetic process",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"HAMAP",
"PANTHER",
"NCBIFAM",
"CDD"
] | [
"MF_01148",
"PTHR38686",
"TIGR00546",
"cd07571"
] | [
"Lnt",
"",
"lnt",
"ALP_N-acyl_transferase"
] | [
18901,
21206,
19376,
18925
] | 4 | [
"EC",
"GP",
"GP",
"METACYC"
] | [
"2.3.1.269",
"GenProp0061",
"GenProp1327",
"PWY-7884"
] | [
"EC:2.3.1.269",
"GP:GenProp0061",
"GP:GenProp1327",
"METACYC:PWY-7884"
] | 4 | [
"5n6h",
"5n6l",
"5n6m",
"5vrg",
"5vrh",
"5xhq",
"6nwr",
"6q3a",
"7aci",
"8aq2",
"8aq3",
"8aq4",
"8b0k",
"8b0l",
"8b0m",
"8b0n",
"8b0o",
"8b0p",
"8q2p",
"8rqr"
] | 20 | [
"PUB00005733",
"PUB00016852",
"PUB00043370",
"PUB00043371"
] | [
"7987228",
"11380987",
"17416655",
"15513925"
] | [
"A new family of carbon-nitrogen hydrolases.",
"The nitrilase superfamily: classification, structure and function.",
"Identification of essential residues in apolipoprotein N-acyl transferase, a member of the CN hydrolase family.",
"Depletion of apolipoprotein N-acyltransferase causes mislocalization of outer... | [
1994,
2001,
2007,
2005
] | 4 | [] | [
"IPR059110"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
4,
20440,
241,
1,
525
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Apolipoprotein N-acyltransferase | Apolipoprotein N-acyltransferase | Apolipo_AcylTrfase | 1 |
IPR004564 | 4,564 | Outer membrane lipoprotein carrier protein LolA-like | OM_lipoprot_carrier_LolA-like | Family | 18,563 | false | false | In Escherichia coli, lipoproteins are anchored to the periplasmic side of either the inner or outer membrane through N-terminal lipids, depending on the lipoprotein-sorting signal present at position 2 [ ]. Five Lol proteins are involved in the sorting and outer membrane localization of lipoproteins. LolCDE, an ATP bin... | [] | [] | [] | 0 | [
"PFAM",
"PFAM",
"PFAM",
"PANTHER",
"CDD"
] | [
"PF03548",
"PF16584",
"PF19574",
"PTHR35869",
"cd16325"
] | [
"LolA",
"LolA_2",
"LolA_3",
"",
"LolA"
] | [
14823,
671,
2439,
13908,
18027
] | 5 | [] | [] | [] | 0 | [
"1iwl",
"1ua8",
"2w7q",
"2zpc",
"2zpd",
"3ksn",
"4ki3",
"4mxt",
"6f3z",
"6fhm",
"7arm",
"7tpm",
"7z6w",
"7z6x",
"8cgm",
"8chx",
"8orn",
"8t5j",
"8t5t",
"8v1k",
"8veh",
"9azz",
"9c89",
"9coz",
"9cwl",
"9gtx"
] | 26 | [
"PUB00007680",
"PUB00061670",
"PUB00061671",
"PUB00061675"
] | [
"12032293",
"19716823",
"20620146",
"20419407"
] | [
"Elucidation of the function of lipoprotein-sorting signals that determine membrane localization.",
"Real time analysis of lipoprotein transfer from LolA to LolB by means of surface plasmon resonance.",
"Hydrophobic surface patches on LolA of Pseudomonas aeruginosa are essential for lipoprotein binding.",
"So... | [
2002,
2009,
2010,
2010
] | 4 | [] | [
"IPR018323"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"unclassified sequences"
] | [
18212,
28,
18,
305
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Outer membrane lipoprotein carrier protein LolA-like | Outer membrane lipoprotein carrier protein LolA-like | OM_lipoprot_carrier_LolA-like | 8 |
IPR004565 | 4,565 | Outer membrane lipoprotein LolB | OM_lipoprot_LolB | Family | 6,675 | false | false | This protein, LolB, is known so far only in the gamma subdivision of the Proteobacteria. It is a processed, lipid-modified outer membrane protein. In Escherichia coli, lipoproteins are anchored to the periplasmic side of either the inner or outer membrane through N-terminal lipids, depending on the lipoprotein-sorting ... | [
"GO:0015031",
"GO:0009279"
] | [
"protein transport",
"cell outer membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"HAMAP",
"PFAM",
"NCBIFAM",
"CDD"
] | [
"MF_00233",
"PF03550",
"TIGR00548",
"cd16326"
] | [
"LolB",
"LolB",
"lolB",
"LolB"
] | [
4278,
6670,
5773,
6236
] | 4 | [
"GP"
] | [
"GenProp0207"
] | [
"GP:GenProp0207"
] | 1 | [
"1iwm",
"1iwn",
"3wjt",
"3wju",
"3wjv",
"8cm1",
"8orn"
] | 7 | [
"PUB00007680"
] | [
"12032293"
] | [
"Elucidation of the function of lipoprotein-sorting signals that determine membrane localization."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
6573,
6,
96
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Outer membrane lipoprotein LolB | Outer membrane lipoprotein LolB | OM_lipoprot_LolB | 4 |
IPR004566 | 4,566 | Pantothenate kinase | PanK | Family | 9,273 | false | false | Pantothenate kinase ( ) catalyses the rate-limiting step in the biosynthesis of coenzyme A, the conversion of pantothenate to D-4'-phosphopantothenate in the presence of ATP. It is very well conserved from Escherichia coli to Bacillus subtilis, but differs considerably from known eukaryotic forms, described in a separa... | [
"GO:0004594",
"GO:0015937"
] | [
"pantothenate kinase activity",
"coenzyme A biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"PIRSF",
"NCBIFAM",
"CDD"
] | [
"MF_00215",
"PIRSF000545",
"TIGR00554",
"cd02025"
] | [
"Pantothen_kinase_1",
"Pantothenate_kin",
"panK_bact",
"PanK"
] | [
9137,
9122,
9268,
9161
] | 4 | [
"EC",
"GP",
"GP",
"GP",
"METACYC"
] | [
"2.7.1.33",
"GenProp0171",
"GenProp1601",
"GenProp1748",
"PWY-3961"
] | [
"EC:2.7.1.33",
"GP:GenProp0171",
"GP:GenProp1601",
"GP:GenProp1748",
"METACYC:PWY-3961"
] | 5 | [
"1esm",
"1esn",
"1sq5",
"2ges",
"2get",
"2geu",
"2gev",
"2zs7",
"2zs8",
"2zs9",
"2zsa",
"2zsb",
"2zsd",
"2zse",
"2zsf",
"3aez",
"3af0",
"3af1",
"3af2",
"3af3",
"3af4",
"3avo",
"3avp",
"3avq",
"3tqc",
"4bfs",
"4bft",
"4bfu",
"4bfv",
"4bfw",
"4bfx",
"4bfy"... | 39 | [
"PUB00017459"
] | [
"7929447"
] | [
"Kinetics and regulation of pantothenate kinase from Escherichia coli."
] | [
1994
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Thermoplasmata",
"metagenomes"
] | [
9189,
6,
11,
67
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Pantothenate kinase | Pantothenate kinase | PanK | 5 |
IPR004567 | 4,567 | Type II pantothenate kinase | Type_II_PanK | Family | 12,683 | false | false | This family describes the type II form of pantothenate kinase PanK, characterised from the fungus Emericella nidulans and with similar forms known in several other eukaryotes. It also includes forms from several Gram-positive bacteria suggested to have originated from the eukaryotic form by lateral transfer. It differs... | [
"GO:0005524",
"GO:0015937"
] | [
"ATP binding",
"coenzyme A biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PANTHER",
"NCBIFAM"
] | [
"PF03630",
"PTHR12280",
"TIGR00555"
] | [
"Fumble",
"",
"panK_eukar"
] | [
11588,
12493,
8597
] | 3 | [
"EC",
"GP",
"GP",
"GP",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.1.33",
"GenProp0171",
"GenProp1561",
"GenProp1748",
"PWY-3961",
"R-BTA-196783",
"R-HSA-196783",
"R-HSA-199220",
"R-MMU-196783",
"R-MMU-199220",
"R-RNO-199220",
"R-SCE-199220",
"R-SPO-199220"
] | [
"EC:2.7.1.33",
"GP:GenProp0171",
"GP:GenProp1561",
"GP:GenProp1748",
"METACYC:PWY-3961",
"REACTOME:R-BTA-196783",
"REACTOME:R-HSA-196783",
"REACTOME:R-HSA-199220",
"REACTOME:R-MMU-196783",
"REACTOME:R-MMU-199220",
"REACTOME:R-RNO-199220",
"REACTOME:R-SCE-199220",
"REACTOME:R-SPO-199220"
] | 13 | [
"1xfi",
"2ews",
"2i7n",
"2i7p",
"2q40",
"3mk6",
"3smp",
"3sms",
"4m7x",
"4m7y",
"4nb4",
"5e26",
"5elz",
"5jic",
"5kpr",
"5kpt",
"5kpz",
"5kq8",
"5kqd",
"6avp",
"6awg",
"6awh",
"6awi",
"6awj",
"6b3v",
"6ebv",
"6pe6",
"6uj5",
"6x4j",
"6x4k",
"6x4l",
"7t1g"... | 53 | [
"PUB00015017",
"PUB00015018",
"PUB00050612"
] | [
"12760898",
"9890959",
"18186650"
] | [
"Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections.",
"Cloning and characterization of a eukaryotic pantothenate kinase gene (panK) from Aspergillus nidulans.",
"Structural basis for substrate binding and the catalytic mechanism of type III pantothenate kinase."
] | [
2003,
1999,
2008
] | 3 | [] | [
"IPR011602",
"IPR015844",
"IPR016949"
] | 0 | 3 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
6,
1102,
11550,
25
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
29,
4,
18,
9,
19,
15,
1,
7,
15,
1,
1,
32
] | 12 | true | Family | Type II pantothenate kinase | Type II pantothenate kinase | Type_II_PanK | 6 |
IPR004568 | 4,568 | Phosphopantetheine-protein transferase domain | Ppantetheine-prot_Trfase_dom | Domain | 22,788 | false | false | This domain is active in transferring the phophopantetheine prosthetic group to its attachment site on enzymes and carrier proteins. Many members of the family containing this domain are small proteins that act on the acyl carrier protein involved in fatty acid biosynthesis [ ]. Some members are domains of larger prote... | [
"GO:0000287",
"GO:0008897",
"GO:0006633"
] | [
"magnesium ion binding",
"holo-[acyl-carrier-protein] synthase activity",
"fatty acid biosynthetic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00556"
] | [
"pantethn_trn"
] | [
22788
] | 1 | [
"EC",
"GP",
"METACYC",
"METACYC"
] | [
"2.7.8.7",
"GenProp1220",
"PWY-6012",
"PWY-6289"
] | [
"EC:2.7.8.7",
"GP:GenProp1220",
"METACYC:PWY-6012",
"METACYC:PWY-6289"
] | 4 | [
"1f7l",
"1f7t",
"1f80",
"1fte",
"1ftf",
"1fth",
"1qr0",
"2bdd",
"2jbz",
"2jca",
"2qg8",
"2uv8",
"2vkz",
"2was",
"2wat",
"2wdo",
"2wds",
"2wdy",
"3gwm",
"3h7q",
"3hmj",
"3hqj",
"3hyk",
"3ne1",
"3ne3",
"3ne9",
"3nfd",
"3qmn",
"4dxe",
"4hc6",
"4jm7",
"4mrt"... | 79 | [
"PUB00095175"
] | [
"24292120"
] | [
"The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life."
] | [
2014
] | 1 | [
"IPR008278"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
54,
19401,
2898,
435
] | 4 | [
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
1,
1,
1,
2,
4
] | 5 | true | Domain | Phosphopantetheine-protein transferase domain | Phosphopantetheine-protein transferase domain | Ppantetheine-prot_Trfase_dom | 4 |
IPR004569 | 4,569 | Pyridoxal phosphate (active vitamin B6) biosynthesis PdxJ | PyrdxlP_synth_PdxJ | Family | 13,655 | false | false | Pyridoxal phosphate is the active form of vitamin B6 (pyridoxine or pyridoxal). Pyridoxal 5'-phosphate (PLP) is a versatile catalyst, acting as a coenzyme in a multitude of reactions, including decarboxylation, deamination and transamination [ , , ]. PLP-dependent enzymes are primarily involved in the biosynthesis of a... | [
"GO:0033856",
"GO:0008615",
"GO:0005737"
] | [
"pyridoxine 5'-phosphate synthase activity",
"pyridoxine biosynthetic process",
"cytoplasm"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"HAMAP",
"PFAM",
"PANTHER",
"NCBIFAM",
"CDD"
] | [
"MF_00279",
"PF03740",
"PTHR30456",
"TIGR00559",
"cd00003"
] | [
"PdxJ",
"PdxJ",
"",
"pdxJ",
"PNPsynthase"
] | [
13381,
13655,
13612,
13117,
12574
] | 5 | [
"EC",
"GP",
"GP"
] | [
"2.6.99.2",
"GenProp0862",
"GenProp1633"
] | [
"EC:2.6.99.2",
"GP:GenProp0862",
"GP:GenProp1633"
] | 3 | [
"1ho1",
"1ho4",
"1ixn",
"1ixo",
"1ixp",
"1ixq",
"1m5w",
"3f4n",
"3gk0",
"3o6c",
"3o6d",
"5dlc",
"6rg0",
"6w6a"
] | 14 | [
"PUB00006322",
"PUB00009884",
"PUB00025731",
"PUB00035504",
"PUB00035505",
"PUB00035506",
"PUB00035507",
"PUB00035508",
"PUB00035509",
"PUB00035510"
] | [
"7748903",
"10225425",
"11286891",
"15581583",
"8690703",
"15189147",
"17109392",
"16763894",
"15242009",
"17344055"
] | [
"Pyridoxal phosphate-dependent enzymes.",
"Vitamin B6 biosynthesis: formation of pyridoxine 5'-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein.",
"Structural basis for the function of pyridoxine 5'-phosphate synthase.",
"Reaction specificity in pyridox... | [
1995,
1999,
2001,
2005,
1995,
2004,
2006,
2006,
2004,
2007
] | 10 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences",
"uncultured marine thaumarchaeote AD1000_100_C06"
] | [
13312,
45,
297,
1
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Pyridoxal phosphate (active vitamin B6) biosynthesis PdxJ | Pyridoxal phosphate (active vitamin B6) biosynthesis PdxJ | PyrdxlP_synth_PdxJ | 5 |
IPR004570 | 4,570 | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase | Phosphatidylglycerol_P_synth | Family | 29,441 | false | false | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase ( ), also known as phosphatidylglycerophosphate synthase, glycerophosphate phosphatidyltransferase and PGP synthase, catalyses the conversion of CDP-diacylglycerol and glycerol-3-phosphate to CMP and 3-(3-phosphatidyl)-glycerol 1-phosphate in the commit... | [
"GO:0008444",
"GO:0008654",
"GO:0016020"
] | [
"CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity",
"phospholipid biosynthetic process",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PIRSF",
"NCBIFAM"
] | [
"PIRSF000847",
"TIGR00560"
] | [
"Phos_ph_gly_syn",
"pgsA"
] | [
27304,
21984
] | 2 | [
"EC",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.7.8.5",
"GenProp1252",
"GenProp1627",
"PWY-5269",
"PWY-5668",
"PWY-7817"
] | [
"EC:2.7.8.5",
"GP:GenProp1252",
"GP:GenProp1627",
"METACYC:PWY-5269",
"METACYC:PWY-5668",
"METACYC:PWY-7817"
] | 6 | [
"7drj",
"7drk"
] | 2 | [] | [] | [] | [] | 0 | [
"IPR000462"
] | [
"IPR023762"
] | 1 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"Myoviridae sp. ctWXg38",
"unclassified sequences"
] | [
27193,
1499,
5,
1,
743
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
5,
1,
2,
3,
10
] | 5 | true | Family | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase | Phosphatidylglycerol_P_synth | 7 |
IPR004572 | 4,572 | Protoporphyrinogen oxidase | Protoporphyrinogen_oxidase | Family | 12,196 | false | false | Protoporphyrinogen oxidase ( ) oxidises protoporphyrinogen IX to protoporphyrin IX, a precursor of haem and chlorophyll, in the penultimate step in haem and porphyrin biosynthesis. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although... | [
"GO:0004729",
"GO:0006779"
] | [
"oxygen-dependent protoporphyrinogen oxidase activity",
"porphyrin-containing compound biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00562"
] | [
"proto_IX_ox"
] | [
12196
] | 1 | [
"EC",
"GP",
"GP",
"GP",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.3.3.4",
"GenProp0221",
"GenProp1421",
"GenProp1663",
"PWY-7159",
"R-BTA-189451",
"R-DDI-189451",
"R-HSA-189451",
"R-MMU-189451",
"R-SCE-189451",
"R-SPO-189451"
] | [
"EC:1.3.3.4",
"GP:GenProp0221",
"GP:GenProp1421",
"GP:GenProp1663",
"METACYC:PWY-7159",
"REACTOME:R-BTA-189451",
"REACTOME:R-DDI-189451",
"REACTOME:R-HSA-189451",
"REACTOME:R-MMU-189451",
"REACTOME:R-SCE-189451",
"REACTOME:R-SPO-189451"
] | 11 | [
"1sez",
"2ivd",
"2ive",
"3i6d",
"3lov",
"3nks",
"4ivm",
"4ivo"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halobacteria",
"Siphoviridae sp. ctJ0s2",
"metagenomes"
] | [
7354,
4648,
81,
1,
112
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
10,
2,
2,
6,
3,
1,
5,
2,
1,
1,
15
] | 11 | true | Family | Protoporphyrinogen oxidase | Protoporphyrinogen oxidase | Protoporphyrinogen_oxidase | 9 |
IPR004573 | 4,573 | rRNA small subunit methyltransferase B | rRNA_ssu_MeTfrase_B | Family | 13,236 | false | false | RNA (C5-cytosine) methyltransferases (RCMTs) catalyse the transfer of a methyl group to the 5th carbon of a cytosine base in RNA sequences to produce C5-methylcytosine. RCMTs use the cofactor S-adenosyl-L-methionine (SAM) as a methyl donor [ ]. The catalytic mechanism of RCMTs involves an attack by the thiolate of a Cy... | [
"GO:0008649",
"GO:0006364"
] | [
"rRNA methyltransferase activity",
"rRNA processing"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00563"
] | [
"rsmB"
] | [
13236
] | 1 | [
"EC"
] | [
"2.1.1.176"
] | [
"EC:2.1.1.176"
] | 1 | [
"1sqf",
"1sqg"
] | 2 | [
"PUB00014203",
"PUB00014204",
"PUB00014205",
"PUB00054125",
"PUB00054126",
"PUB00054127",
"PUB00054128",
"PUB00054129",
"PUB00054130"
] | [
"10026269",
"14656444",
"10454610",
"12826405",
"12220187",
"19135144",
"20007150",
"10194318",
"15121902"
] | [
"Purification, cloning, and characterization of the 16S RNA m5C967 methyltransferase from Escherichia coli.",
"The first structure of an RNA m5C methyltransferase, Fmu, provides insight into catalytic mechanism and specific binding of RNA substrate.",
"Exposition of a family of RNA m(5)C methyltransferases from... | [
1999,
2003,
1999,
2003,
2002,
2009,
2010,
1999,
2004
] | 9 | [
"IPR023267"
] | [
"IPR023541"
] | 1 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"unclassified sequences"
] | [
12862,
254,
3,
117
] | 4 | [
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
1,
2,
2
] | 3 | true | Family | rRNA small subunit methyltransferase B | rRNA small subunit methyltransferase B | rRNA_ssu_MeTfrase_B | 9 |
IPR004574 | 4,574 | Alkylated DNA repair protein AlkB | Alkb | Family | 11,777 | false | false | AlkB proteins are dioxygenases that repair alkylation damage to DNA and RNA [ ]. The Escherichia coli alkB gene product protects against cell killing by S(N)2-alkylating agents through DNA repair by a novel direct reversal DNA repair mechanism: the oxidative demethylation of N1-methyladenine or N3-methylcytosine DNA le... | [] | [] | [] | 0 | [
"PANTHER",
"NCBIFAM"
] | [
"PTHR16557",
"TIGR00568"
] | [
"",
"alkb"
] | [
11777,
344
] | 2 | [
"EC"
] | [
"1.14.11"
] | [
"EC:1.14.11"
] | 1 | [
"2fd8",
"2fdf",
"2fdg",
"2fdh",
"2fdi",
"2fdj",
"2fdk",
"3bi3",
"3bie",
"3bkz",
"3i2o",
"3i3m",
"3i3q",
"3i49",
"3khb",
"3khc",
"3o1m",
"3o1o",
"3o1p",
"3o1r",
"3o1s",
"3o1t",
"3o1u",
"3o1v",
"3t3y",
"3t4h",
"3t4v",
"4jht",
"4nid",
"4nig",
"4nih",
"4nii"... | 46 | [
"PUB00010126",
"PUB00076916",
"PUB00076917",
"PUB00088328"
] | [
"12517444",
"12594517",
"26152727",
"28257121"
] | [
"AlkB mystery solved: oxidative demethylation of N1-methyladenine and N3-methylcytosine adducts by a direct reversal mechanism.",
"Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA.",
"The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid ... | [
2003,
2003,
2015,
2017
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
6300,
5447,
30
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
16,
1,
3,
1,
1,
2,
3,
1,
9,
5,
1,
11
] | 12 | true | Family | Alkylated DNA repair protein AlkB | Alkylated DNA repair protein AlkB | Alkb | 6 |
IPR004575 | 4,575 | Cdk-activating kinase assembly factor MAT1/Tfb3 | MAT1/Tfb3 | Family | 3,181 | false | false | MAT1/Tfb3 acts as component of the general transcription and DNA repair factor IIH (TFIIH), which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA [ ]. It is a RING finger protein with a characteristic C3HC4 motif located in the N-terminal domai... | [
"GO:0061575",
"GO:0006289",
"GO:0045737",
"GO:0005675"
] | [
"cyclin-dependent protein serine/threonine kinase activator activity",
"nucleotide-excision repair",
"positive regulation of cyclin-dependent protein serine/threonine kinase activity",
"transcription factor TFIIH holo complex"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PIRSF",
"NCBIFAM"
] | [
"PIRSF003338",
"TIGR00570"
] | [
"MAT1_metazoa",
"cdk7"
] | [
947,
3181
] | 2 | [
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"GenProp2049",
"R-HSA-112382",
"R-HSA-113418",
"R-HSA-167152",
"R-HSA-167158",
"R-HSA-167160",
"R-HSA-167161",
"R-HSA-167162",
"R-HSA-167172",
"R-HSA-167200",
"R-HSA-167246",
"R-HSA-427413",
"R-HSA-5696395",
"R-HSA-674695",
"R-HSA-6781823",
"R-HSA-6781827",
"R-HSA-6782135",
"R-HSA-... | [
"GP:GenProp2049",
"REACTOME:R-HSA-112382",
"REACTOME:R-HSA-113418",
"REACTOME:R-HSA-167152",
"REACTOME:R-HSA-167158",
"REACTOME:R-HSA-167160",
"REACTOME:R-HSA-167161",
"REACTOME:R-HSA-167162",
"REACTOME:R-HSA-167172",
"REACTOME:R-HSA-167200",
"REACTOME:R-HSA-167246",
"REACTOME:R-HSA-427413",
... | 86 | [
"5oqj",
"5oqm",
"6gym",
"6nmi",
"6o9l",
"6o9m",
"6xbz",
"7b5o",
"7b5q",
"7egb",
"7egc",
"7ena",
"7enc",
"7kue",
"7lbm",
"7ml0",
"7ml1",
"7ml2",
"7ml3",
"7ml4",
"7nvr",
"7nvw",
"7nvx",
"7nvy",
"7nvz",
"7nw0",
"7o4i",
"7o4j",
"7o4k",
"7o4l",
"7o72",
"7o73"... | 57 | [
"PUB00007681",
"PUB00007682",
"PUB00062852"
] | [
"11007478",
"11447116",
"9235928"
] | [
"Molecular structure of human TFIIH.",
"T-loop phosphorylation stabilizes the CDK7-cyclin H-MAT1 complex in vivo and regulates its CTD kinase activity.",
"Genes for Tfb2, Tfb3, and Tfb4 subunits of yeast transcription/repair factor IIH. Homology to human cyclin-dependent kinase activating kinase and IIH subunit... | [
2000,
2001,
1997
] | 3 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
3181
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
1,
2,
2,
4,
4,
1,
6,
1,
1
] | 9 | true | Family | Cdk-activating kinase assembly factor MAT1/Tfb3 | Cdk-activating kinase assembly factor MAT1/Tfb3 | MAT1/Tfb3 | 1 |
IPR004576 | 4,576 | Transcription-repair coupling factor | Mfd | Family | 26,163 | false | false | The bacterial transcription-repair coupling factor (Mfd) binds to stalled transcription elongation complexes in vitro and catalyses their dissociation from template DNA in an ATP-dependent manner [ ]. A lesion in the template strand blocks the RNA polymerase complex (RNAP). The RNAP-DNA-RNA complex is specifically reco... | [
"GO:0003684",
"GO:0005524",
"GO:0006281"
] | [
"damaged DNA binding",
"ATP binding",
"DNA repair"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_00969",
"TIGR00580"
] | [
"TRCF",
"mfd"
] | [
26094,
25225
] | 2 | [
"EC",
"GP",
"METACYC"
] | [
"3.6.4.-",
"GenProp1153",
"PWY-7250"
] | [
"EC:3.6.4.-",
"GP:GenProp1153",
"METACYC:PWY-7250"
] | 3 | [
"2eyq",
"6ac6",
"6ac8",
"6aca",
"6acx",
"6m6a",
"6m6b",
"6x26",
"6x2f",
"6x2n",
"6x43",
"6x4w",
"6x4y",
"6x50",
"6xeo",
"7ssg",
"9n07",
"9n11"
] | 18 | [
"PUB00069794",
"PUB00069795",
"PUB00069796",
"PUB00069797",
"PUB00069798"
] | [
"22904071",
"7876262",
"21145481",
"12086674",
"15063847"
] | [
"Multipartite control of the DNA translocase, Mfd.",
"Structure and function of transcription-repair coupling factor. II. Catalytic properties.",
"Regulation and rate enhancement during transcription-coupled DNA repair.",
"E. coli Transcription repair coupling factor (Mfd protein) rescues arrested complexes b... | [
2012,
1995,
2010,
2002,
2004
] | 5 | [
"IPR047112"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
25702,
38,
423
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Transcription-repair coupling factor | Transcription-repair coupling factor | Mfd | 5 |
IPR004577 | 4,577 | 8-oxoguanine DNA-glycosylase | Ogg1 | Family | 379 | false | false | One of the major base lesions induced by oxidative stress is 8-oxoguanine (8-oxoG), one of the oxidised forms of guanine. 8-oxoguanine DNA glycosylase (also known as N-glycosylase/DNA lyase) functions in base excision repair and is responsible for the excision of 8-oxoguanine. It has beta-lyase activity that nicks DNA ... | [
"GO:0008534",
"GO:0034039",
"GO:0006284"
] | [
"oxidized purine nucleobase lesion DNA N-glycosylase activity",
"8-oxo-7,8-dihydroguanine DNA N-glycosylase activity",
"base-excision repair"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00588"
] | [
"ogg"
] | [
379
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.2.2.-",
"4.2.99.18",
"PWY-2681",
"PWY-5316",
"PWY-5381",
"PWY-7342",
"PWY-7564",
"PWY-8106",
"R-HSA-110328",
"R-HSA-110329",
"R-HSA-110330",
"R-HSA-110331",
"R-HSA-110357",
"R-HSA-5649702",
"R-HSA-9656255",
"R-HSA-9656256",
"R-HSA-9657050",
"R-MMU-110329",
"R-MMU-110330",
"R... | [
"EC:3.2.2.-",
"EC:4.2.99.18",
"METACYC:PWY-2681",
"METACYC:PWY-5316",
"METACYC:PWY-5381",
"METACYC:PWY-7342",
"METACYC:PWY-7564",
"METACYC:PWY-8106",
"REACTOME:R-HSA-110328",
"REACTOME:R-HSA-110329",
"REACTOME:R-HSA-110330",
"REACTOME:R-HSA-110331",
"REACTOME:R-HSA-110357",
"REACTOME:R-HSA... | 30 | [
"1ebm",
"1fn7",
"1hu0",
"1ko9",
"1lwv",
"1lww",
"1lwy",
"1m3h",
"1m3q",
"1n39",
"1n3a",
"1n3c",
"1yqk",
"1yql",
"1yqm",
"1yqr",
"2i5w",
"2nob",
"2noe",
"2nof",
"2noh",
"2noi",
"2nol",
"2noz",
"2xhi",
"3ih7",
"3ktu",
"5an4",
"6g3x",
"6g3y",
"6g40",
"6rlw"... | 67 | [
"PUB00074987",
"PUB00074988",
"PUB00074989"
] | [
"8805338",
"8643552",
"9187114"
] | [
"Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily.",
"Cloning and expression in Escherichia coli of the OGG1 gene of Saccharomyces cerevisiae, which codes for a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-... | [
1996,
1996,
1997
] | 3 | [] | [] | 0 | 0 | null | [
"Methanothermobacter",
"Opisthokonta"
] | [
2,
377
] | 2 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
9,
2,
3,
1
] | 4 | true | Family | 8-oxoguanine DNA-glycosylase | 8-oxoguanine DNA-glycosylase | Ogg1 | 9 |
IPR004580 | 4,580 | DNA repair protein Rad18, fungi | Rad18_fungi | Family | 1,137 | false | false | During DNA replication, lesion bypass is an important cellular response to unrepaired damage in the genome. In the yeast Saccharomyces cerevisiae (Baker's yeast), Rad6 and Rad18 are required for both the error-free and error-prone lesion bypass mechanisms. The Rad18 gene encodes a RING-finger protein with single-strand... | [
"GO:0003697",
"GO:0061630",
"GO:0006301",
"GO:0006513"
] | [
"single-stranded DNA binding",
"ubiquitin protein ligase activity",
"DNA damage tolerance",
"protein monoubiquitination"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"biological_process"
] | 4 | [
"NCBIFAM"
] | [
"TIGR00599"
] | [
"rad18"
] | [
1137
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.3.2.27",
"PWY-7511",
"R-SCE-8866654",
"R-SPO-110314",
"R-SPO-8866654"
] | [
"EC:2.3.2.27",
"METACYC:PWY-7511",
"REACTOME:R-SCE-8866654",
"REACTOME:R-SPO-110314",
"REACTOME:R-SPO-8866654"
] | 5 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR039577"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
1137
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Family | DNA repair protein Rad18, fungi | DNA repair protein Rad18, fungi | Rad18_fungi | 7 |
IPR004582 | 4,582 | Checkpoint protein Rad17/Rad24 | Checkpoint_prot_Rad17_Rad24 | Family | 5,659 | false | false | This entry represents checkpoint protein Rad24 from budding yeasts and its homologue, Rad17 from other organisms. In Saccharomyces cerevisiae, Rad24 forms a complex with replication factor C (RFC) proteins, including Rfc2, Rfc3, Rfc4, and Rfc5. When DNA damage is detected, the Rad24-RFC complex loads Rad17-Mec3-Ddc1 co... | [
"GO:0006281"
] | [
"DNA repair"
] | [
"biological_process"
] | 1 | [
"PANTHER"
] | [
"PTHR12172"
] | [
""
] | [
5659
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-176187",
"R-HSA-5685938",
"R-HSA-5693607",
"R-HSA-5693616",
"R-HSA-6804756",
"R-HSA-69473",
"R-HSA-9709570",
"R-MMU-176187",
"R-MMU-5685938",
"R-MMU-5693607",
"R-MMU-6804756",
"R-MMU-69473",
"R-SCE-176187",
"R-SPO-176187"
] | [
"REACTOME:R-HSA-176187",
"REACTOME:R-HSA-5685938",
"REACTOME:R-HSA-5693607",
"REACTOME:R-HSA-5693616",
"REACTOME:R-HSA-6804756",
"REACTOME:R-HSA-69473",
"REACTOME:R-HSA-9709570",
"REACTOME:R-MMU-176187",
"REACTOME:R-MMU-5685938",
"REACTOME:R-MMU-5693607",
"REACTOME:R-MMU-6804756",
"REACTOME:R-... | 14 | [
"7sgz",
"7sh2",
"7st9",
"7stb",
"7ste",
"7z6h",
"8dqw",
"8fs3",
"8fs4",
"8fs5",
"8fs6",
"8fs7",
"8fs8"
] | 13 | [
"PUB00059229",
"PUB00062362",
"PUB00062364",
"PUB00062365",
"PUB00062366",
"PUB00062367",
"PUB00062368",
"PUB00062369",
"PUB00062370"
] | [
"12604797",
"15297881",
"10511543",
"12944484",
"11267834",
"10675560",
"15454530",
"10232579",
"11555598"
] | [
"Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint.",
"Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination.",
"Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partn... | [
2003,
2004,
1999,
2003,
2001,
2000,
2004,
1999,
2001
] | 9 | [] | [
"IPR018324"
] | 0 | 1 | 0 | [
"Eukaryota",
"mine drainage metagenome"
] | [
5658,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
10,
1,
2,
4,
8,
3,
1,
7,
4,
1,
1,
27
] | 12 | true | Family | Checkpoint protein Rad17/Rad24 | Checkpoint protein Rad17/Rad24 | Checkpoint_prot_Rad17_Rad24 | 6 |
IPR004583 | 4,583 | DNA repair protein Rad4 | DNA_repair_Rad4 | Family | 6,434 | false | false | Mutations in the nucleotide excision repair (NER) pathway can cause the xeroderma pigmentosum skin cancer predisposition syndrome. NER lesions are limited to one DNA strand, but otherwise they are chemically and structurally diverse, being caused by a wide variety of genotoxic chemicals and ultraviolet radiation. The x... | [
"GO:0003684",
"GO:0006289",
"GO:0005634"
] | [
"damaged DNA binding",
"nucleotide-excision repair",
"nucleus"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PANTHER"
] | [
"PTHR12135"
] | [
""
] | [
6434
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-5696394",
"R-DME-5696395",
"R-HSA-3108214",
"R-HSA-5696394",
"R-HSA-5696395",
"R-MMU-3108214",
"R-MMU-5696394",
"R-MMU-5696395",
"R-SCE-3108214",
"R-SPO-3108214",
"R-SPO-5696395"
] | [
"REACTOME:R-DME-5696394",
"REACTOME:R-DME-5696395",
"REACTOME:R-HSA-3108214",
"REACTOME:R-HSA-5696394",
"REACTOME:R-HSA-5696395",
"REACTOME:R-MMU-3108214",
"REACTOME:R-MMU-5696394",
"REACTOME:R-MMU-5696395",
"REACTOME:R-SCE-3108214",
"REACTOME:R-SPO-3108214",
"REACTOME:R-SPO-5696395"
] | 11 | [
"2qsf",
"2qsg",
"2qsh",
"4yir",
"6cfi",
"6ubf",
"6ug1",
"6uin",
"7k04",
"7m2u",
"8ebs",
"8ebt",
"8ebu",
"8ebv",
"8ebw",
"8ebx",
"8eby"
] | 17 | [
"PUB00007684",
"PUB00044171"
] | [
"10915862",
"17882165"
] | [
"Nucleotide excision repair in yeast.",
"Recognition of DNA damage by the Rad4 nucleotide excision repair protein."
] | [
2000,
2007
] | 2 | [] | [
"IPR018026"
] | 0 | 1 | 0 | [
"Eukaryota",
"Gimesia benthica"
] | [
6433,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
6,
1,
2,
1,
16,
3,
2,
3,
2,
2,
2,
4
] | 12 | true | Family | DNA repair protein Rad4 | DNA repair protein Rad4 | DNA_repair_Rad4 | 6 |
IPR004584 | 4,584 | DNA repair protein Rad50, eukaryotes | Rad50_eukaryotes | Family | 3,789 | false | false | RAD50 is involved in DNA double-strand break repair (DSBR), telomere maintenance and meiotic recombination [ , , ]. The RAD50/MRE11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific exonuclease activity [ , ]. RAD50 provides ATP-dependent control of Mre11 by unwinding and/or... | [
"GO:0016887",
"GO:0000723",
"GO:0006281",
"GO:0005634",
"GO:0030870"
] | [
"ATP hydrolysis activity",
"telomere maintenance",
"DNA repair",
"nucleus",
"Mre11 complex"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component",
"cellular_component"
] | 5 | [
"NCBIFAM"
] | [
"TIGR00606"
] | [
"rad50"
] | [
3789
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-5685939",
"R-CEL-5693548",
"R-CEL-5693607",
"R-DME-2559586",
"R-DME-5685939",
"R-DME-5693548",
"R-DME-5693565",
"R-DME-5693607",
"R-DME-6804756",
"R-DME-69473",
"R-HSA-2559586",
"R-HSA-5685938",
"R-HSA-5685939",
"R-HSA-5685942",
"R-HSA-5693548",
"R-HSA-5693554",
"R-HSA-5693565... | [
"REACTOME:R-CEL-5685939",
"REACTOME:R-CEL-5693548",
"REACTOME:R-CEL-5693607",
"REACTOME:R-DME-2559586",
"REACTOME:R-DME-5685939",
"REACTOME:R-DME-5693548",
"REACTOME:R-DME-5693565",
"REACTOME:R-DME-5693607",
"REACTOME:R-DME-6804756",
"REACTOME:R-DME-69473",
"REACTOME:R-HSA-2559586",
"REACTOME:... | 64 | [
"7zr1",
"9bi4",
"9bi5",
"9q9h",
"9q9i",
"9q9j",
"9q9k",
"9q9m"
] | 8 | [
"PUB00062772",
"PUB00062773",
"PUB00062774",
"PUB00062775",
"PUB00062776",
"PUB00062777",
"PUB00072593",
"PUB00072599",
"PUB00072600",
"PUB00072747"
] | [
"9590181",
"15296753",
"15135728",
"9705271",
"11454871",
"17698079",
"19409520",
"24168161",
"23671188",
"21734400"
] | [
"The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response.",
"The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage.",
"Disruption of Drosophila Rad50 causes pupal lethality, the ... | [
1998,
2004,
2004,
1998,
2001,
2007,
2009,
2014,
2013,
2011
] | 10 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3789
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizo... | [
4,
2,
1,
3,
11,
6,
1,
3,
1,
1,
3
] | 11 | true | Family | DNA repair protein Rad50, eukaryotes | DNA repair protein Rad50, eukaryotes | Rad50_eukaryotes | 5 |
IPR004585 | 4,585 | DNA recombination/repair protein Rad52 | DNA_recomb/repair_Rad52 | Family | 2,194 | false | false | Rad52 was identified in Saccharomyces cerevisiae (Baker's yeast) as a component of the homologous recombination repair pathway and to play an important role in both meiotic and mitotic recombination. The human protein is highly homologous in both structure and function. In the presence of absence of DNA, Rad52 forms ri... | [
"GO:0000724",
"GO:0000730",
"GO:0045002",
"GO:0005634"
] | [
"double-strand break repair via homologous recombination",
"DNA recombinase assembly",
"double-strand break repair via single-strand annealing",
"nucleus"
] | [
"biological_process",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"NCBIFAM"
] | [
"TIGR00607"
] | [
"rad52"
] | [
2194
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-3108214",
"R-HSA-5685938",
"R-HSA-5685939",
"R-MMU-3108214",
"R-MMU-5685938",
"R-MMU-5685939",
"R-SCE-3108214",
"R-SCE-5685938",
"R-SPO-3108214",
"R-SPO-5685938"
] | [
"REACTOME:R-HSA-3108214",
"REACTOME:R-HSA-5685938",
"REACTOME:R-HSA-5685939",
"REACTOME:R-MMU-3108214",
"REACTOME:R-MMU-5685938",
"REACTOME:R-MMU-5685939",
"REACTOME:R-SCE-3108214",
"REACTOME:R-SCE-5685938",
"REACTOME:R-SPO-3108214",
"REACTOME:R-SPO-5685938"
] | 10 | [
"1h2i",
"1kn0",
"5jrb",
"5xrz",
"5xs0",
"8bjm",
"8g3g",
"8h1p",
"8ril",
"8rj3",
"8rjw",
"8tkq"
] | 12 | [
"PUB00007686"
] | [
"12226092"
] | [
"Correlation of biochemical properties with the oligomeric state of human rad52 protein."
] | [
2002
] | 1 | [
"IPR007232"
] | [] | 1 | 0 | 1 | [
"Opisthokonta"
] | [
2194
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
3,
5,
3,
1,
4,
1,
2
] | 7 | true | Family | DNA recombination/repair protein Rad52 | DNA recombination/repair protein Rad52 | DNA_recomb/repair_Rad52 | 9 |
IPR004586 | 4,586 | RecBCD enzyme subunit RecB | RecB | Family | 8,068 | false | false | Exodeoxyribonuclease V, or RecBCD holoenzyme, ( ) is a multifunctional nuclease with potent ATP-dependent exodeoxyribonuclease activity. Ejection of RecD, as occurs at chi recombinational hotspots, cripples exonuclease activity in favor of recombinagenic helicase activity. All proteins in this family for which function... | [
"GO:0005524",
"GO:0008854",
"GO:0006281"
] | [
"ATP binding",
"exodeoxyribonuclease V activity",
"DNA repair"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_01485",
"TIGR00609"
] | [
"RecB",
"recB"
] | [
8002,
6382
] | 2 | [
"EC",
"EC",
"GP",
"GP"
] | [
"3.1.11.5",
"5.6.2.4",
"GenProp0216",
"GenProp1188"
] | [
"EC:3.1.11.5",
"EC:5.6.2.4",
"GP:GenProp0216",
"GP:GenProp1188"
] | 4 | [
"1w36",
"3k70",
"5ld2",
"5mbv",
"6sjb",
"6sje",
"6sjf",
"6sjg",
"6t2u",
"6t2v",
"7mr0",
"7mr1",
"7mr2",
"7mr3",
"7mr4",
"8b1r",
"8b1t",
"8b1u"
] | 18 | [
"PUB00033616"
] | [
"15538360"
] | [
"Crystal structure of RecBCD enzyme reveals a machine for processing DNA breaks."
] | [
2004
] | 1 | [
"IPR000212"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
8010,
6,
52
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | RecBCD enzyme subunit RecB | RecBCD enzyme subunit RecB | RecB | 4 |
IPR004588 | 4,588 | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type | IspG_bac-typ | Family | 23,763 | false | false | This protein previously of unknown biochemical function is essential in Escherichia coli. It has now been characterised as 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase, which converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4CPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate in the sixth step... | [
"GO:0046429",
"GO:0016114"
] | [
"4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity (ferredoxin)",
"terpenoid biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"PANTHER",
"NCBIFAM"
] | [
"MF_00159",
"PTHR30454",
"TIGR00612"
] | [
"IspG",
"",
"ispG_gcpE"
] | [
22497,
23761,
22628
] | 3 | [
"EC",
"GP",
"GP"
] | [
"1.17.7.3",
"GenProp0048",
"GenProp1295"
] | [
"EC:1.17.7.3",
"GP:GenProp0048",
"GP:GenProp1295"
] | 3 | [
"2y0f",
"3noy",
"4g9p",
"4mwa",
"4s23",
"4s38",
"4s39",
"4s3a",
"4s3b",
"4s3c",
"4s3d",
"4s3e",
"4s3f"
] | 13 | [] | [] | [] | [] | 0 | [] | [
"IPR016425",
"IPR017178"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences",
"virus sp. ctVE78"
] | [
4,
21775,
1299,
684,
1
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
4,
1,
2,
7
] | 4 | true | Family | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type | IspG_bac-typ | 3 |
IPR004590 | 4,590 | DNA single-strand annealing protein RecT | ssDNA_annealing_RecT | Family | 3,031 | false | false | All proteins in this family for which functions are known bind single-stranded DNA and are involved in the the pairing of homologous DNA. RecT from Escherichia coli is a homotetramer which binds to single-stranded DNA and promotes the renaturation of complementary single-stranded DNA, and also plays a role in recombina... | [
"GO:0003677",
"GO:0006259"
] | [
"DNA binding",
"DNA metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00616"
] | [
"rect"
] | [
3031
] | 1 | [] | [] | [] | 0 | [
"7ub2",
"7ubb"
] | 2 | [
"PUB00007687"
] | [
"12169595"
] | [
"Roles of RecJ, RecO, and RecR in RecET-mediated illegitimate recombination in Escherichia coli."
] | [
2002
] | 1 | [
"IPR018330"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Opisthokonta",
"Viruses",
"metagenomes"
] | [
2492,
7,
441,
91
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | DNA single-strand annealing protein RecT | DNA single-strand annealing protein RecT | ssDNA_annealing_RecT | 6 |
IPR004591 | 4,591 | Replication factor A protein 1 | Rfa1 | Family | 6,321 | false | false | Rfa1 (also known as RPA70) is a component of the replication protein A (RPA) complex, which binds to and removes secondary structure from ssDNA. The RPA complex is involved in DNA replication, repair, and recombination [ ], and it also plays a role in telomere maintenance [ ]. | [
"GO:0003677",
"GO:0006260",
"GO:0006281",
"GO:0006310",
"GO:0005634"
] | [
"DNA binding",
"DNA replication",
"DNA repair",
"DNA recombination",
"nucleus"
] | [
"molecular_function",
"biological_process",
"biological_process",
"biological_process",
"cellular_component"
] | 5 | [
"NCBIFAM"
] | [
"TIGR00617"
] | [
"rpa1"
] | [
6321
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-110312",
"R-CEL-110314",
"R-CEL-110320",
"R-CEL-176187",
"R-CEL-5651801",
"R-CEL-5655862",
"R-CEL-5656121",
"R-CEL-5656169",
"R-CEL-5693607",
"R-CEL-5696397",
"R-CEL-5696400",
"R-CEL-6782135",
"R-CEL-6782210",
"R-CEL-68962",
"R-CEL-69166",
"R-DME-110312",
"R-DME-110314",
"R-... | [
"REACTOME:R-CEL-110312",
"REACTOME:R-CEL-110314",
"REACTOME:R-CEL-110320",
"REACTOME:R-CEL-176187",
"REACTOME:R-CEL-5651801",
"REACTOME:R-CEL-5655862",
"REACTOME:R-CEL-5656121",
"REACTOME:R-CEL-5656169",
"REACTOME:R-CEL-5693607",
"REACTOME:R-CEL-5696397",
"REACTOME:R-CEL-5696400",
"REACTOME:R-... | 175 | [
"1fgu",
"1jmc",
"4gnx",
"4gop",
"8rk2"
] | 5 | [
"PUB00070983",
"PUB00153035"
] | [
"20012581",
"34767620"
] | [
"Eukaryotic single-stranded DNA binding proteins: central factors in genome stability.",
"Gain-of-function mutations in RPA1 cause a syndrome with short telomeres and somatic genetic rescue."
] | [
2010,
2022
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6321
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
20,
1,
1,
1,
1,
3,
1,
4,
5,
1,
1,
16
] | 12 | true | Family | Replication factor A protein 1 | Replication factor A protein 1 | Rfa1 | 6 |
IPR004592 | 4,592 | Nuclease SbcC, gammaproteobacteria type | SbcC_gammaproteobac_type | Family | 1,864 | false | false | This entry represents a small group of nuclease SbcCD subunit C (SbcC) proteins, mainly from gammaproteobacteria. SbcC are known are part of an exonuclease complex with sbcD homologues. SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR00618"
] | [
"sbcc"
] | [
1864
] | 1 | [] | [] | [] | 0 | [
"6s6v",
"6s85",
"7yzo",
"7yzp",
"7z03"
] | 5 | [
"PUB00061927"
] | [
"17704228"
] | [
"The sbcDC locus mediates repression of type 5 capsule production as part of the SOS response in Staphylococcus aureus."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Beauveria bassiana D1-5"
] | [
1863,
1
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Nuclease SbcC, gammaproteobacteria type | Nuclease SbcC, gammaproteobacteria type | SbcC_gammaproteobac_type | 9 |
IPR004593 | 4,593 | Nuclease SbcCD subunit D | SbcD | Family | 14,513 | false | false | SbcCD cleaves DNA hairpin structures [ ]. This complex functions in the initiation of recombination and recombinational repair and is particularly important in regulating the stability of DNA sections that can form secondary structures [ ]. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. ... | [
"GO:0004519",
"GO:0008408",
"GO:0006259"
] | [
"endonuclease activity",
"3'-5' exonuclease activity",
"DNA metabolic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00619"
] | [
"sbcd"
] | [
14513
] | 1 | [] | [] | [] | 0 | [
"2q8u",
"3qg5",
"3thn",
"3tho",
"4lty",
"4lu9",
"4m0v",
"4nzv",
"4o24",
"4o43",
"4o4k",
"4o5g",
"6asc",
"6s6v",
"6s85",
"6x1y",
"6x1z",
"7dog",
"7yzo",
"7yzp",
"7z03"
] | 21 | [
"PUB00017341",
"PUB00061924",
"PUB00070790",
"PUB00070791",
"PUB00070792"
] | [
"9653124",
"9133662",
"9927737",
"19897571",
"24531464"
] | [
"The SbcCD nuclease of Escherichia coli is a structural maintenance of chromosomes (SMC) family protein that cleaves hairpin DNA.",
"The sbcC and sbcD genes of Escherichia coli encode a nuclease involved in palindrome inviability and genetic recombination.",
"DNA cleavage and degradation by the SbcCD protein co... | [
1998,
1996,
1999,
2010,
2014
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
19,
14349,
15,
130
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Nuclease SbcCD subunit D | Nuclease SbcCD subunit D | SbcD | 6 |
IPR004595 | 4,595 | TFIIH C1-like domain | TFIIH_C1-like_dom | Domain | 3,872 | false | false | The carboxyl-terminal region of TFIIH is essential for transcription activity. This regions binds three zinc atoms through two independent domains. The first contains a C4 zinc finger motif, whereas the second is characterised by a CX(2)CX(2-4)FCADCD motif. The solution structure of the second C-terminal domain reveale... | [
"GO:0008270",
"GO:0006281"
] | [
"zinc ion binding",
"DNA repair"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"SMART"
] | [
"PF07975",
"SM01047"
] | [
"C1_4",
"C1_4"
] | [
3607,
3872
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-113418",
"R-BTA-5696395",
"R-BTA-5696400",
"R-BTA-674695",
"R-BTA-6781823",
"R-BTA-6782135",
"R-BTA-6782210",
"R-BTA-6796648",
"R-BTA-72086",
"R-BTA-73762",
"R-BTA-73772",
"R-BTA-73776",
"R-BTA-73779",
"R-BTA-73863",
"R-BTA-75953",
"R-BTA-75955",
"R-BTA-76042",
"R-BTA-77075"... | [
"REACTOME:R-BTA-113418",
"REACTOME:R-BTA-5696395",
"REACTOME:R-BTA-5696400",
"REACTOME:R-BTA-674695",
"REACTOME:R-BTA-6781823",
"REACTOME:R-BTA-6782135",
"REACTOME:R-BTA-6782210",
"REACTOME:R-BTA-6796648",
"REACTOME:R-BTA-72086",
"REACTOME:R-BTA-73762",
"REACTOME:R-BTA-73772",
"REACTOME:R-BTA-... | 144 | [
"1z60",
"5ivw",
"5iy6",
"5iy7",
"5iy8",
"5iy9",
"5nus",
"5o85",
"5obz",
"5of4",
"5oqj",
"5oqm",
"6gym",
"6nmi",
"6o9l",
"6o9m",
"6ro4",
"7ad8",
"7egb",
"7egc",
"7ena",
"7enc",
"7k01",
"7k04",
"7lbm",
"7m2u",
"7ml0",
"7ml1",
"7ml2",
"7ml3",
"7ml4",
"7nvr"... | 73 | [
"PUB00016526"
] | [
"10882739"
] | [
"Structural characterization of the cysteine-rich domain of TFIIH p44 subunit."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3872
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
2,
1,
3,
4,
2,
2,
2,
1,
1,
4
] | 12 | true | Domain | TFIIH C1-like domain | TFIIH C1-like domain | TFIIH_C1-like_dom | 2 |
IPR004596 | 4,596 | Cell division suppressor protein, SulA | Cell_div_suppressor_SulA | Family | 2,795 | false | false | All proteins in this family for which the functions are known are cell division inhibitors. In Escherichia coli, SulA is one of the SOS regulated genes. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, SulA binds a polymerisation-com... | [
"GO:0009432",
"GO:0051782"
] | [
"SOS response",
"negative regulation of cell division"
] | [
"biological_process",
"biological_process"
] | 2 | [
"PFAM",
"PIRSF"
] | [
"PF03846",
"PIRSF003093"
] | [
"SulA",
"SulA"
] | [
2792,
1285
] | 2 | [] | [] | [] | 0 | [
"1oft",
"1ofu"
] | 2 | [
"PUB00029417",
"PUB00151020"
] | [
"12808143",
"22432817"
] | [
"Crystal structure of the SOS cell division inhibitor SulA and in complex with FtsZ.",
"SulA inhibits assembly of FtsZ by a simple sequestration mechanism."
] | [
2003,
2012
] | 2 | [] | [
"IPR047696"
] | 0 | 1 | 0 | [
"Bacteria",
"Thelohanellus kitauei",
"metagenomes"
] | [
2774,
1,
20
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Cell division suppressor protein, SulA | Cell division suppressor protein, SulA | Cell_div_suppressor_SulA | 3 |
IPR004597 | 4,597 | DNA-3-methyladenine glycosylase I | Tag | Family | 8,937 | false | false | One common form of damage to DNA occurs when alkyl groups become covalently linked to DNA, leading to the formation of mutagenic or toxic lesions. Alkylating agents are ubiquitous in the environment and can also exist endogenously; for example S-adenosylmethionine, a commonly used methyl donor in many cellualr pathways... | [
"GO:0008725",
"GO:0006284"
] | [
"DNA-3-methyladenine glycosylase activity",
"base-excision repair"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00624"
] | [
"tag"
] | [
8937
] | 1 | [] | [] | [] | 0 | [
"1lmz",
"1nku",
"1p7m",
"2ofi",
"2ofk"
] | 5 | [
"PUB00017507",
"PUB00022105",
"PUB00034744",
"PUB00034745"
] | [
"3536912",
"12161745",
"16464003",
"10606811"
] | [
"Purification and structure of 3-methyladenine-DNA glycosylase I of Escherichia coli.",
"3-Methyladenine DNA glycosylase I is an unexpected helix-hairpin-helix superfamily member.",
"Direct reversal of DNA alkylation damage.",
"A phylogenomic study of DNA repair genes, proteins, and processes."
] | [
1986,
2002,
2006,
1999
] | 4 | [
"IPR005019"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
16,
8823,
33,
65
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | DNA-3-methyladenine glycosylase I | DNA-3-methyladenine glycosylase I | Tag | 6 |
IPR004598 | 4,598 | Transcription factor TFIIH subunit p52/Tfb2 | TFIIH_p52/Tfb2 | Family | 4,788 | false | false | This entry represents the p52/Tfb2 subunit in the TFIIH complex, which is not only required for transcription but also plays a central role in DNA repair. The TFIIH multiprotein complex consists of a 7-subunit core (XPB, p62, p52, p44, p34, and TTDA) that is associated with a 3-subunit CDK-activating kinase module (MAT... | [
"GO:0001671",
"GO:0006289",
"GO:0000439"
] | [
"ATPase activator activity",
"nucleotide-excision repair",
"transcription factor TFIIH core complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PANTHER",
"NCBIFAM"
] | [
"PF03849",
"PTHR13152",
"TIGR00625"
] | [
"Tfb2",
"",
"tfb2"
] | [
4707,
4698,
3294
] | 3 | [
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"GenProp2048",
"R-DDI-113418",
"R-DDI-5696395",
"R-DDI-674695",
"R-DDI-6781823",
"R-DDI-6782135",
"R-DDI-6782210",
"R-DDI-6796648",
"R-DDI-72086",
"R-DDI-73772",
"R-DDI-73776",
"R-DDI-73779",
"R-DDI-75953",
"R-DDI-76042",
"R-DDI-77075",
"R-HSA-112382",
"R-HSA-113418",
"R-HSA-167152... | [
"GP:GenProp2048",
"REACTOME:R-DDI-113418",
"REACTOME:R-DDI-5696395",
"REACTOME:R-DDI-674695",
"REACTOME:R-DDI-6781823",
"REACTOME:R-DDI-6782135",
"REACTOME:R-DDI-6782210",
"REACTOME:R-DDI-6796648",
"REACTOME:R-DDI-72086",
"REACTOME:R-DDI-73772",
"REACTOME:R-DDI-73776",
"REACTOME:R-DDI-73779",
... | 91 | [
"3dgp",
"3dom",
"5fmf",
"5ivw",
"5iy6",
"5iy7",
"5iy8",
"5iy9",
"5of4",
"5oqj",
"5oqm",
"5sva",
"6gym",
"6nmi",
"6o9l",
"6o9m",
"6ro4",
"6trs",
"6tru",
"7ad8",
"7egb",
"7egc",
"7ena",
"7enc",
"7k01",
"7k04",
"7lbm",
"7m2u",
"7ml0",
"7ml1",
"7ml2",
"7ml3"... | 75 | [
"PUB00062739",
"PUB00062740",
"PUB00062813",
"PUB00089653"
] | [
"22308316",
"22572993",
"21592869",
"17466626"
] | [
"Subunit architecture of general transcription factor TFIIH.",
"TFIIH: when transcription met DNA repair.",
"A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor.",
"Distinct roles for the XPB/p52 and XPD/p44 subcomplexes of TFIIH in damaged DNA opening during nucleoti... | [
2012,
2012,
2011,
2007
] | 4 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Eukaryota",
"bird metagenome"
] | [
3,
4783,
2
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
6,
4,
1,
3,
5,
7,
1,
4,
3,
1,
1,
7
] | 12 | true | Family | Transcription factor TFIIH subunit p52/Tfb2 | Transcription factor TFIIH subunit p52/Tfb2 | TFIIH_p52/Tfb2 | 2 |
IPR004600 | 4,600 | TFIIH subunit Tfb4/GTF2H3 | TFIIH_Tfb4/GTF2H3 | Family | 4,617 | false | false | This entry represents Tfb4/GTF2H3, a component of the transcription factor TFIIH core (includes XPB, p62, p52, p44, p34). TFIIH complex is involved in the nucleotide excision repair (NER) and polymerase II transcription [ , , ]. | [
"GO:0006289",
"GO:0006355",
"GO:0000439"
] | [
"nucleotide-excision repair",
"regulation of DNA-templated transcription",
"transcription factor TFIIH core complex"
] | [
"biological_process",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PANTHER",
"NCBIFAM"
] | [
"PF03850",
"PTHR12831",
"TIGR00627"
] | [
"Tfb4",
"",
"tfb4"
] | [
4604,
4484,
806
] | 3 | [
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"GenProp2048",
"R-BTA-113418",
"R-BTA-5696395",
"R-BTA-5696400",
"R-BTA-674695",
"R-BTA-6781823",
"R-BTA-6782135",
"R-BTA-6782210",
"R-BTA-6796648",
"R-BTA-72086",
"R-BTA-73762",
"R-BTA-73772",
"R-BTA-73776",
"R-BTA-73779",
"R-BTA-73863",
"R-BTA-75953",
"R-BTA-75955",
"R-BTA-76042"... | [
"GP:GenProp2048",
"REACTOME:R-BTA-113418",
"REACTOME:R-BTA-5696395",
"REACTOME:R-BTA-5696400",
"REACTOME:R-BTA-674695",
"REACTOME:R-BTA-6781823",
"REACTOME:R-BTA-6782135",
"REACTOME:R-BTA-6782210",
"REACTOME:R-BTA-6796648",
"REACTOME:R-BTA-72086",
"REACTOME:R-BTA-73762",
"REACTOME:R-BTA-73772"... | 128 | [
"4pn7",
"5ivw",
"5iy6",
"5iy7",
"5iy8",
"5iy9",
"5nus",
"5o85",
"5obz",
"5of4",
"5oqj",
"5oqm",
"6gym",
"6nmi",
"6o9l",
"6o9m",
"6ro4",
"7ad8",
"7egb",
"7egc",
"7ena",
"7enc",
"7k01",
"7k04",
"7lbm",
"7m2u",
"7ml0",
"7ml1",
"7ml2",
"7ml3",
"7ml4",
"7nvr"... | 72 | [
"PUB00056880",
"PUB00062838",
"PUB00062851"
] | [
"8631896",
"7961739",
"10506223"
] | [
"Reconstitution of TFIIH and requirement of its DNA helicase subunits, Rad3 and Rad25, in the incision step of nucleotide excision repair.",
"RNA polymerase transcription factor IIH holoenzyme from yeast.",
"The TFB4 subunit of yeast TFIIH is required for both nucleotide excision repair and RNA polymerase II tr... | [
1996,
1994,
1999
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4617
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
1,
1,
2,
10,
2,
1,
3,
4,
1,
1,
3
] | 12 | true | Family | TFIIH subunit Tfb4/GTF2H3 | TFIIH subunit Tfb4/GTF2H3 | TFIIH_Tfb4/GTF2H3 | 3 |
IPR004601 | 4,601 | UV-endonuclease UvdE | UvdE | Family | 5,014 | false | false | Proteins in this family are a group of endonucleases for the repair of UV-irradiated DNA. Schizosaccharomyces pombe ultraviolet damage endonuclease (UVDE or Uve1p) is involved in the excision of cyclobutane pyrimidine dimers (CPD) and 6-4 pyrimidine pyrimidones (6-4PP) which forms the UV damage repair (UVDR) pathway. I... | [
"GO:0004519",
"GO:0006289",
"GO:0009411"
] | [
"endonuclease activity",
"nucleotide-excision repair",
"response to UV"
] | [
"molecular_function",
"biological_process",
"biological_process"
] | 3 | [
"PFAM",
"PANTHER",
"NCBIFAM"
] | [
"PF03851",
"PTHR31290",
"TIGR00629"
] | [
"UvdE",
"",
"uvde"
] | [
5003,
4968,
4466
] | 3 | [] | [] | [] | 0 | [
"2j6v",
"3bzg",
"3bzj",
"3c0l",
"3c0q",
"3c0s",
"3tc3",
"4gle"
] | 8 | [
"PUB00014886",
"PUB00014887",
"PUB00060419",
"PUB00060420",
"PUB00060421",
"PUB00060422"
] | [
"10801329",
"11807060",
"8614629",
"9023111",
"14599746",
"14704348"
] | [
"Ultraviolet damage endonuclease (Uve1p): a structure and strand-specific DNA endonuclease.",
"Genetic evidence that the uvsE gene product of Deinococcus radiodurans R1 is a UV damage endonuclease.",
"Characterization of a UV endonuclease gene from the fission yeast Schizosaccharomyces pombe and its bacterial h... | [
2000,
2002,
1996,
1997,
2003,
2004
] | 6 | [] | [
"IPR023520"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
104,
3286,
1482,
90,
52
] | 5 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1
] | 2 | true | Family | UV-endonuclease UvdE | UV-endonuclease UvdE | UvdE | 7 |
IPR004602 | 4,602 | UvrABC system subunit A | UvrA | Family | 32,598 | false | false | In Eubacteria and some Archaea, the first steps in nucleotide excision repair are carried out by the coordinated action of the UvrA, UvrB, and UvrC proteins. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged sit... | [
"GO:0003677",
"GO:0016887",
"GO:0006289",
"GO:0009380"
] | [
"DNA binding",
"ATP hydrolysis activity",
"nucleotide-excision repair",
"excinuclease repair complex"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_00205",
"TIGR00630"
] | [
"UvrA",
"uvra"
] | [
21730,
32583
] | 2 | [
"GP",
"GP",
"GP"
] | [
"GenProp0114",
"GenProp1109",
"GenProp1153"
] | [
"GP:GenProp0114",
"GP:GenProp1109",
"GP:GenProp1153"
] | 3 | [
"2r6f",
"2vf7",
"2vf8",
"3pih",
"3uwx",
"3ux8",
"3zqj",
"6n9l",
"9ga2",
"9ga3",
"9ga4",
"9ga5"
] | 12 | [
"PUB00057848",
"PUB00057850"
] | [
"12145219",
"11421287"
] | [
"The presence of two UvrB subunits in the UvrAB complex ensures damage detection in both DNA strands.",
"Role of ATP hydrolysis by UvrA and UvrB during nucleotide excision repair."
] | [
2002,
2001
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
606,
31394,
62,
2,
534
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | UvrABC system subunit A | UvrABC system subunit A | UvrA | 9 |
IPR004604 | 4,604 | DNA recombination/repair protein RecN | DNA_recomb/repair_RecN | Family | 26,538 | false | false | DNA repair protein RecN is thought to be DNA damage inducible and involved in recombinational processes. RecN is part of the AAA+ superfamily of ATPases. The N-terminal region of most of the bacterial RecN proteins sequenced to date contains an ATP/GTP binding domain within an SMC-like motif. SMC-like domains are invol... | [
"GO:0005524",
"GO:0006281",
"GO:0006310"
] | [
"ATP binding",
"DNA repair",
"DNA recombination"
] | [
"molecular_function",
"biological_process",
"biological_process"
] | 3 | [
"PIRSF",
"PANTHER",
"NCBIFAM"
] | [
"PIRSF003128",
"PTHR11059",
"TIGR00634"
] | [
"RecN",
"",
"recN"
] | [
24442,
26538,
23554
] | 3 | [
"GP"
] | [
"GenProp0491"
] | [
"GP:GenProp0491"
] | 1 | [
"4abx",
"4aby",
"4ad8"
] | 3 | [
"PUB00007688",
"PUB00057226"
] | [
"11807051",
"11473577"
] | [
"Roles of the recJ and recN genes in homologous recombination and DNA repair pathways of Neisseria gonorrhoeae.",
"AAA+ superfamily ATPases: common structure--diverse function."
] | [
2002,
2001
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"Methanobacteriota",
"unclassified sequences"
] | [
25748,
2,
146,
8,
634
] | 5 | [
"Escherichia coli (strain K12)",
"Homo sapiens"
] | [
1,
1
] | 2 | true | Family | DNA recombination/repair protein RecN | DNA recombination/repair protein RecN | DNA_recomb/repair_RecN | 5 |
IPR004605 | 4,605 | Holliday junction branch migration complex subunit RuvB | DNA_helicase_Holl-junc_RuvB | Family | 25,835 | false | false | This entry represents Holliday junction branch migration complex subunit RuvB, which as part of a complex with RuvA homologues serve as a 5'-3' Holliday junction helicase. RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with t... | [
"GO:0003677",
"GO:0005524",
"GO:0009378",
"GO:0006281",
"GO:0006310"
] | [
"DNA binding",
"ATP binding",
"four-way junction helicase activity",
"DNA repair",
"DNA recombination"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process",
"biological_process"
] | 5 | [
"HAMAP",
"PANTHER",
"NCBIFAM"
] | [
"MF_00016",
"PTHR42848",
"TIGR00635"
] | [
"DNA_HJ_migration_RuvB",
"",
"ruvB"
] | [
25305,
25833,
25019
] | 3 | [
"EC",
"GP",
"METACYC"
] | [
"3.6.4.-",
"GenProp0198",
"PWY-7250"
] | [
"EC:3.6.4.-",
"GP:GenProp0198",
"METACYC:PWY-7250"
] | 3 | [
"1hqc",
"1in4",
"1in5",
"1in6",
"1in7",
"1in8",
"1ixr",
"1ixs",
"1j7k",
"3pfi",
"6blb",
"7pbl",
"7pbm",
"7pbn",
"7pbo",
"7pbp",
"7pbq",
"7pbr",
"7pbs",
"7pbt",
"7x5b",
"7x7p",
"7x7q",
"8efv",
"8efy"
] | 25 | [
"PUB00013198"
] | [
"12408833"
] | [
"Crystal structure of the RuvA-RuvB complex: a structural basis for the Holliday junction migrating motor machinery."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
24985,
74,
48,
3,
725
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Holliday junction branch migration complex subunit RuvB | Holliday junction branch migration complex subunit RuvB | DNA_helicase_Holl-junc_RuvB | 1 |
IPR004607 | 4,607 | Phosphoribosylglycinamide formyltransferase | GART | Family | 28,204 | false | false | Phosphoribosylglycinamide formyltransferase, also known as GAR transformylase or GART, is an essential enzyme that catalyzes the third step in de novo purine biosynthesis [ ]. This enzyme uses formyl tetrahydrofolate as a formyl group donor to produce 5'-phosphoribosyl-N-formylglycinamide. In prokaryotes, GART is a sin... | [
"GO:0004644",
"GO:0006189"
] | [
"phosphoribosylglycinamide formyltransferase activity",
"'de novo' IMP biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"NCBIFAM",
"CDD"
] | [
"MF_01930",
"TIGR00639",
"cd08645"
] | [
"PurN",
"PurN",
"FMT_core_GART"
] | [
26406,
26657,
27278
] | 3 | [
"EC",
"GP",
"GP",
"GP",
"GP",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.1.2.2",
"GenProp0110",
"GenProp1216",
"GenProp1284",
"GenProp1406",
"PWY-6121",
"PWY-6613",
"R-BTA-73817",
"R-DME-73817",
"R-GGA-419140",
"R-HSA-73817",
"R-MMU-73817"
] | [
"EC:2.1.2.2",
"GP:GenProp0110",
"GP:GenProp1216",
"GP:GenProp1284",
"GP:GenProp1406",
"METACYC:PWY-6121",
"METACYC:PWY-6613",
"REACTOME:R-BTA-73817",
"REACTOME:R-DME-73817",
"REACTOME:R-GGA-419140",
"REACTOME:R-HSA-73817",
"REACTOME:R-MMU-73817"
] | 12 | [
"1c2t",
"1c3e",
"1cdd",
"1cde",
"1gar",
"1grc",
"1jkx",
"1mej",
"1men",
"1meo",
"1njs",
"1rbm",
"1rbq",
"1rby",
"1rbz",
"1rc0",
"1rc1",
"1zlx",
"1zly",
"2gar",
"2ywr",
"3auf",
"3av3",
"3da8",
"3dcj",
"3gar",
"3kcq",
"3p9x",
"3tqr",
"4ds3",
"4ew1",
"4ew2"... | 58 | [
"PUB00027303",
"PUB00075622",
"PUB00080573"
] | [
"12450384",
"2147474",
"8876651"
] | [
"Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR.",
"De novo purine nucleotide biosynthesis: cloning of human and avian cDNAs encoding the trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase by ... | [
2002,
1990,
1996
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
567,
23035,
4138,
8,
456
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
4,
1,
4,
3,
1,
5,
2,
1,
5,
2,
1,
1,
2
] | 13 | true | Family | Phosphoribosylglycinamide formyltransferase | Phosphoribosylglycinamide formyltransferase | GART | 1 |
IPR004608 | 4,608 | Methylmalonyl-CoA mutase, small subunit | MMCoA_mutase_b | Family | 1,044 | false | false | Methylmalonyl-CoA mutase ( ) catalyses the isomerization of succinyl-CoA to methylmalonyl-CoA during the synthesis of propionate from tricarboxylic acid-cycle intermediates in propionic acid fermentation. The adenosylcobalamin-binding, catalytic chain of methylmalonyl-CoA mutase may form homodimers, as in the mitochond... | [
"GO:0004494"
] | [
"methylmalonyl-CoA mutase activity"
] | [
"molecular_function"
] | 1 | [
"NCBIFAM"
] | [
"TIGR00642"
] | [
"mmCoA_mut_beta"
] | [
1044
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"5.4.99.2",
"PWY-5743",
"PWY-5789",
"PWY-6728",
"PWY-7384",
"PWY-7854",
"PWY-8086"
] | [
"EC:5.4.99.2",
"METACYC:PWY-5743",
"METACYC:PWY-5789",
"METACYC:PWY-6728",
"METACYC:PWY-7384",
"METACYC:PWY-7854",
"METACYC:PWY-8086"
] | 7 | [
"1e1c",
"1req",
"2req",
"3req",
"4req",
"5req",
"6oxc",
"6oxd",
"6req",
"7req"
] | 10 | [
"PUB00014831"
] | [
"9242908"
] | [
"Structure-based perspectives on B12-dependent enzymes."
] | [
1997
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
1032,
12
] | 2 | [] | [] | 0 | true | Family | Methylmalonyl-CoA mutase, small subunit | Methylmalonyl-CoA mutase, small subunit | MMCoA_mutase_b | 7 |
IPR004609 | 4,609 | ATP-dependent DNA helicase RecG | ATP-dep_DNA_helicase_RecG | Family | 19,306 | false | false | The ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. It helps to process Holliday junction intermediates to mature products by catalysing branch migration. This entry includes RecG from bacteria the homologue from Arabidopsis, which has a critical role in recombination and DNA repa... | [
"GO:0003678",
"GO:0006281",
"GO:0006310"
] | [
"DNA helicase activity",
"DNA repair",
"DNA recombination"
] | [
"molecular_function",
"biological_process",
"biological_process"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00643"
] | [
"recG"
] | [
19306
] | 1 | [
"EC"
] | [
"5.6.2.4"
] | [
"EC:5.6.2.4"
] | 1 | [
"1gm5"
] | 1 | [
"PUB00025306",
"PUB00060423",
"PUB00060424",
"PUB00098842"
] | [
"11595187",
"7957087",
"7774596",
"25484163"
] | [
"Structural analysis of DNA replication fork reversal by RecG.",
"Branch migration of Holliday junctions: identification of RecG protein as a junction specific DNA helicase.",
"Escherichia coli RecG and RecA proteins in R-loop formation.",
"Genetic analysis of Escherichia coli RadA: functional motifs and gene... | [
2001,
1994,
1995,
2015
] | 4 | [
"IPR047112"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Pseudomonas phage YMC12/01/R24",
"unclassified sequences",
"uncultured marine thaumarchaeote KM3_68_B04"
] | [
18501,
479,
1,
324,
1
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
2,
1,
1,
1
] | 4 | true | Family | ATP-dependent DNA helicase RecG | ATP-dependent DNA helicase RecG | ATP-dep_DNA_helicase_RecG | 7 |
IPR004610 | 4,610 | Bacterial RecJ exonuclease | RecJ | Family | 20,982 | false | false | All proteins in this family are 5'-3' single-strand DNA exonucleases. These proteins are used in some aspects of mismatch repair, recombination, and recombinational repair. RecJ is a single-stranded DNA-specific endonuclease which is required for many types of recombination events, although the stringency of the requir... | [
"GO:0008409",
"GO:0006281",
"GO:0006310"
] | [
"5'-3' exonuclease activity",
"DNA repair",
"DNA recombination"
] | [
"molecular_function",
"biological_process",
"biological_process"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00644"
] | [
"recJ"
] | [
20982
] | 1 | [
"GP"
] | [
"GenProp0491"
] | [
"GP:GenProp0491"
] | 1 | [
"5f54",
"5f55",
"5f56",
"6lrd",
"8y30"
] | 5 | [
"PUB00091449"
] | [
"27058167"
] | [
"Structural basis for DNA 5´-end resection by RecJ."
] | [
2016
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Marine Group III euryarchaeote",
"Viruses",
"unclassified sequences"
] | [
20739,
23,
1,
3,
216
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Bacterial RecJ exonuclease | Bacterial RecJ exonuclease | RecJ | 4 |
IPR004611 | 4,611 | DNA primase-related protein | DNA_primase-rel | Family | 6 | false | false | The DNA primase DnaG of Escherichia coli and its apparent orthologs in other bacterial species are approximately 600 residues in length. Within this set, a conspicuous outlier in percent identity, as seen in a UPGMA difference tree, is the branch containing the Mycoplasmas. This lineage is also unique in containing the... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR00646"
] | [
"MG010"
] | [
6
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Mycoplasmoides"
] | [
6
] | 1 | [] | [] | 0 | true | Family | DNA primase-related protein | DNA primase-related protein | DNA_primase-rel | 5 |
IPR004612 | 4,612 | Holliday junction resolvase RecU | Resolv_RecU | Family | 4,243 | false | false | This entry includes the Bacillus subtilis RecU protein and similar proteins predominantly found in Firmicutes. RecU has been shown to be required for DNA recombination and repair [ , , , ]. | [
"GO:0006281"
] | [
"DNA repair"
] | [
"biological_process"
] | 1 | [
"HAMAP",
"PFAM",
"PIRSF",
"NCBIFAM",
"CDD"
] | [
"MF_00130",
"PF03838",
"PIRSF037785",
"TIGR00648",
"cd22354"
] | [
"RecU",
"RecU",
"RecU",
"recU",
"RecU-like"
] | [
3852,
4236,
3526,
2773,
3777
] | 5 | [
"EC",
"GP"
] | [
"3.1.21.10",
"GenProp0198"
] | [
"EC:3.1.21.10",
"GP:GenProp0198"
] | 2 | [
"1rzn",
"1y1o",
"1zp7",
"2fco",
"5fdk"
] | 5 | [
"PUB00038978",
"PUB00047439",
"PUB00057245",
"PUB00057246"
] | [
"16154091",
"17557334",
"14701911",
"16020779"
] | [
"The structure of Bacillus subtilis RecU Holliday junction resolvase and its role in substrate selection and sequence-specific cleavage.",
"Structure, flexibility, and mechanism of the Bacillus stearothermophilus RecU Holliday junction resolvase.",
"Bacillus subtilis RecU protein cleaves Holliday junctions and ... | [
2005,
2007,
2004,
2005
] | 4 | [] | [] | 0 | 0 | null | [
"Acyrthosiphon pisum",
"Bacteria",
"Viruses",
"metagenomes"
] | [
1,
4177,
45,
20
] | 4 | [] | [] | 0 | true | Family | Holliday junction resolvase RecU | Holliday junction resolvase RecU | Resolv_RecU | 5 |
IPR004613 | 4,613 | Ribonuclease J | RNase_J | Family | 17,845 | false | false | This family of proteins are about 50 to 77kDa. The central region is well conserved and contains three conserved histidines. Most of these proteins are related at the N-terminal region to the beta-lactamase family. The family has been characterised as ribonuclease J. RNase J cleaves the 5'-leader sequence of certain mR... | [
"GO:0003723",
"GO:0046872"
] | [
"RNA binding",
"metal ion binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00649"
] | [
"MG423"
] | [
17845
] | 1 | [] | [] | [] | 0 | [
"3bk1",
"3bk2",
"3t3n",
"3t3o",
"3zq4",
"4xwt",
"4xww",
"5a0t",
"5a0v",
"5haa",
"5hab",
"5ws2",
"6k6s",
"6k6w",
"6llb",
"7pcr",
"7wnt",
"7wnu",
"8cgl",
"8yyf",
"8yyg",
"8yyh",
"8yyi",
"8yyj",
"8yyk"
] | 25 | [
"PUB00074172",
"PUB00074173",
"PUB00074174"
] | [
"19540834",
"22014150",
"23093592"
] | [
"RNase J is involved in the 5'-end maturation of 16S rRNA and 23S rRNA in Sinorhizobium meliloti.",
"Mycobacterium smegmatis RNase J is a 5'-3' exo-/endoribonuclease and both RNase J and RNase E are involved in ribosomal RNA maturation.",
"A minimal bacterial RNase J-based degradosome is associated with transla... | [
2009,
2011,
2013
] | 3 | [] | [
"IPR030854",
"IPR030879"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
654,
16926,
15,
250
] | 4 | [] | [] | 0 | true | Family | Ribonuclease J | Ribonuclease J | RNase_J | 7 |
IPR004614 | 4,614 | Phosphate acetyltransferase | P_AcTrfase | Domain | 15,970 | false | false | Phosphate acetyltransferase ( ) catalyses the conversion of acetyl-CoA and phosphate to CoA and acetyl phosphate in the last two steps in the conversion of actetae to acetyl-CoA. | [
"GO:0016407"
] | [
"acetyltransferase activity"
] | [
"molecular_function"
] | 1 | [
"NCBIFAM"
] | [
"TIGR00651"
] | [
"pta"
] | [
15970
] | 1 | [
"EC",
"GP",
"GP",
"GP",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.3.1.8",
"GenProp0478",
"GenProp1267",
"GenProp1345",
"GenProp1543",
"GenProp1749",
"PWY-1281",
"PWY-5482",
"PWY-5485",
"PWY-5497",
"PWY-6637",
"PWY-8086",
"PWY-8377"
] | [
"EC:2.3.1.8",
"GP:GenProp0478",
"GP:GenProp1267",
"GP:GenProp1345",
"GP:GenProp1543",
"GP:GenProp1749",
"METACYC:PWY-1281",
"METACYC:PWY-5482",
"METACYC:PWY-5485",
"METACYC:PWY-5497",
"METACYC:PWY-6637",
"METACYC:PWY-8086",
"METACYC:PWY-8377"
] | 13 | [
"1qzt",
"1r5j",
"1td9",
"1vmi",
"1xco",
"2af3",
"2af4",
"4e4r",
"6iow",
"6iox",
"7t88",
"8fir"
] | 12 | [] | [] | [] | [] | 0 | [
"IPR002505"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
35,
15648,
203,
84
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Domain | Phosphate acetyltransferase | Phosphate acetyltransferase | P_AcTrfase | 3 |
IPR004615 | 4,615 | DNA polymerase III, psi subunit | DNA_pol_III_psi | Family | 2,065 | false | false | DNA-directed DNA polymerase ( ) catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The enzyme also has 3' to 5' exonuclease activity. It has a core compose... | [
"GO:0003887",
"GO:0008408",
"GO:0006260"
] | [
"DNA-directed DNA polymerase activity",
"3'-5' exonuclease activity",
"DNA replication"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM",
"PIRSF"
] | [
"PF03603",
"PIRSF029225"
] | [
"DNA_III_psi",
"DNA_pol_III_psi"
] | [
2065,
1839
] | 2 | [
"GP"
] | [
"GenProp1117"
] | [
"GP:GenProp1117"
] | 1 | [
"1em8",
"3gli",
"3sxu",
"8giy",
"8giz",
"8gj0",
"8gj1",
"8gj2",
"8gj3"
] | 9 | [] | [] | [] | [] | 0 | [] | [
"IPR018382"
] | 0 | 1 | 0 | [
"Bacteria",
"Ecdysozoa",
"ecological metagenomes"
] | [
2060,
2,
3
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | DNA polymerase III, psi subunit | DNA polymerase III, psi subunit | DNA_pol_III_psi | 1 |
IPR004616 | 4,616 | Leucyl/phenylalanyl-tRNA-protein transferase | Leu/Phe-tRNA_Trfase | Family | 13,888 | false | false | Leucyl/phenylalanyl-tRNA--protein transferase transfers a Leu or Phe to the amino end of certain proteins to enable degradation. The N-terminal residue controls the biological half-life of many proteins via the N-end rule pathway. | [
"GO:0008914",
"GO:0030163"
] | [
"leucyl-tRNA--protein transferase activity",
"protein catabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"PFAM",
"PANTHER",
"NCBIFAM"
] | [
"MF_00688",
"PF03588",
"PTHR30098",
"TIGR00667"
] | [
"Leu_Phe_trans",
"Leu_Phe_trans",
"",
"aat"
] | [
13078,
13748,
13839,
12923
] | 4 | [
"EC",
"GP",
"METACYC"
] | [
"2.3.2.6",
"GenProp1495",
"PWY-7801"
] | [
"EC:2.3.2.6",
"GP:GenProp1495",
"METACYC:PWY-7801"
] | 3 | [
"2cxa",
"2dps",
"2dpt",
"2z3k",
"2z3l",
"2z3m",
"2z3n",
"2z3o",
"2z3p"
] | 9 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences",
"uncultured marine thaumarchaeote KM3_70_D04"
] | [
13111,
512,
264,
1
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Leucyl/phenylalanyl-tRNA-protein transferase | Leucyl/phenylalanyl-tRNA-protein transferase | Leu/Phe-tRNA_Trfase | 6 |
IPR004617 | 4,617 | Bis(5'-nucleosyl)-tetraphosphatase, symmetrical | ApaH | Family | 6,825 | false | false | This protein family represents Bis(5'-nucleosyl)-tetraphosphatase, symmetrical (ApaH, also known as Ap4A hydrolase) from Escherichia coli and similar proteins predominantly found in Proteobacteria. This enzyme hydrolyses diadenosine 5',5"'-P1,P4-tetraphosphate (Ap4A), a regulatory metabolite of stress conditions, to yi... | [
"GO:0008803"
] | [
"bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity"
] | [
"molecular_function"
] | 1 | [
"HAMAP",
"PIRSF",
"NCBIFAM",
"CDD"
] | [
"MF_00199",
"PIRSF000903",
"TIGR00668",
"cd07422"
] | [
"ApaH",
"B5n-ttraPtase_sm",
"apaH",
"MPP_ApaH"
] | [
4716,
6657,
6696,
6094
] | 4 | [
"EC"
] | [
"3.6.1.41"
] | [
"EC:3.6.1.41"
] | 1 | [
"2dfj",
"9ojd",
"9ojp",
"9ojq",
"9ojw",
"9ojx",
"9ok1",
"9ok2",
"9oln",
"9oly",
"9olz",
"9om9",
"9omc",
"9omu",
"9omw",
"9omx",
"9on0",
"9on7",
"9ond",
"9ong",
"9oon",
"9ooy",
"9op2",
"9opg",
"9oph",
"9oq9",
"9oqb"
] | 27 | [
"PUB00014455"
] | [
"6317672"
] | [
"Catabolism of diadenosine 5',5\"'-P1,P4-tetraphosphate in procaryotes. Purification and properties of diadenosine 5',5\"'-P1,P4-tetraphosphate (symmetrical) pyrophosphohydrolase from Escherichia coli K12."
] | [
1983
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
6727,
9,
89
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Bis(5'-nucleosyl)-tetraphosphatase, symmetrical | Bis(5'-nucleosyl)-tetraphosphatase, symmetrical | ApaH | 3 |
IPR004618 | 4,618 | Aspartate--ammonia ligase | AsnA | Family | 5,309 | false | false | Aspartate--ammonia ligase (asparagine synthetase) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. This family represents one of the two non-homologous forms of aspartate--ammonia ligase found in Escherichia coli. This type is also found in Haemophilus influenzae, Treponema pa... | [
"GO:0004071",
"GO:0070981",
"GO:0005737"
] | [
"aspartate-ammonia ligase activity",
"L-asparagine biosynthetic process",
"cytoplasm"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"HAMAP",
"PFAM",
"PIRSF",
"PANTHER",
"NCBIFAM",
"CDD"
] | [
"MF_00555",
"PF03590",
"PIRSF001555",
"PTHR30073",
"TIGR00669",
"cd00645"
] | [
"AsnA",
"AsnA",
"Asp_ammon_ligase",
"",
"asnA",
"AsnA"
] | [
4524,
5256,
4967,
5303,
4931,
2226
] | 6 | [
"EC",
"GP",
"GP"
] | [
"6.3.1.1",
"GenProp0259",
"GenProp1404"
] | [
"EC:6.3.1.1",
"GP:GenProp0259",
"GP:GenProp1404"
] | 3 | [
"11as",
"12as",
"4lns"
] | 3 | [
"PUB00080089"
] | [
"1346128"
] | [
"A relationship between asparagine synthetase A and aspartyl tRNA synthetase."
] | [
1992
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Heterosigma akashiwo virus 01",
"candidate division MSBL1 archaeon SCGC-AAA382M17",
"unclassified sequences"
] | [
5003,
247,
1,
1,
57
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Aspartate--ammonia ligase | Aspartate--ammonia ligase | AsnA | 3 |
IPR004619 | 4,619 | Type III pantothenate kinase | Type_III_PanK | Family | 18,191 | false | false | This entry represents the type III pantothenate kinase family, such as that found in Helicobacter pylori. PanK III enzymes have a much wider phylogenic distribution than PanK I, and differs significantly in biochemical activity. PanK III enzymes are are not feedback inhibited by CoA concentration (which is also the cas... | [
"GO:0004594"
] | [
"pantothenate kinase activity"
] | [
"molecular_function"
] | 1 | [
"HAMAP",
"PFAM",
"PANTHER",
"NCBIFAM"
] | [
"MF_01274",
"PF03309",
"PTHR34265",
"TIGR00671"
] | [
"Pantothen_kinase_3",
"Pan_kinase",
"",
"baf"
] | [
17672,
18168,
17993,
17879
] | 4 | [
"EC",
"GP",
"METACYC"
] | [
"2.7.1.33",
"GenProp0171",
"PWY-3961"
] | [
"EC:2.7.1.33",
"GP:GenProp0171",
"METACYC:PWY-3961"
] | 3 | [
"2f9t",
"2f9w",
"2gtd",
"2h3g",
"2nrh",
"3bex",
"3bf1",
"3bf3",
"3djc",
"4o5f",
"4o8k",
"5b8h",
"9b78",
"9b79",
"9cku"
] | 15 | [
"PUB00040460",
"PUB00050612"
] | [
"16905099",
"18186650"
] | [
"Prokaryotic type II and type III pantothenate kinases: The same monomer fold creates dimers with distinct catalytic properties.",
"Structural basis for substrate binding and the catalytic mechanism of type III pantothenate kinase."
] | [
2006,
2008
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctYaH2",
"unclassified sequences",
"uncultured marine thaumarchaeote KM3_78_A04"
] | [
17597,
82,
1,
510,
1
] | 5 | [] | [] | 0 | true | Family | Type III pantothenate kinase | Type III pantothenate kinase | Type_III_PanK | 4 |
IPR004620 | 4,620 | 5,10-methylenetetrahydrofolate reductase | MTHF_reductase_bac | Family | 15,538 | false | false | This entry represents a family that includes bacterial 5,10-methylenetetrahydrofolate reductase (FADH). The enzyme activities methylenetetrahydrofolate reductase ( ) and 5,10-methylenetetrahydrofolate reductase (FADH) ( ) differ in that the former (assigned in many eukaryotes) is defined to use NADP+ as an acceptor, wh... | [
"GO:0004489",
"GO:0005829"
] | [
"methylenetetrahydrofolate reductase [NAD(P)H] activity",
"cytosol"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00676"
] | [
"fadh2"
] | [
15538
] | 1 | [
"EC",
"GP",
"METACYC",
"METACYC"
] | [
"1.5.1.54",
"GenProp1356",
"PWY-2201",
"PWY-3841"
] | [
"EC:1.5.1.54",
"GP:GenProp1356",
"METACYC:PWY-2201",
"METACYC:PWY-3841"
] | 4 | [
"1b5t",
"1v93",
"1zp3",
"1zp4",
"1zpt",
"1zrq",
"2fmn",
"2fmo",
"3apt",
"3apy",
"3fst",
"3fsu",
"5ume",
"6pey",
"7rml",
"7th4",
"7th5",
"8eac"
] | 18 | [
"PUB00006438"
] | [
"10201405"
] | [
"The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Promethearchaeum syntrophicum",
"metagenomes"
] | [
15088,
207,
1,
242
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)"
] | [
3,
1
] | 2 | true | Family | 5,10-methylenetetrahydrofolate reductase | 5,10-methylenetetrahydrofolate reductase | MTHF_reductase_bac | 4 |
IPR004622 | 4,622 | DNA polymerase III, delta prime subunit | DNA_pol_HolB | Domain | 12,076 | false | false | DNA-directed DNA polymerase ( ) catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. DNA polymerase III is a complex, multi-chain enzyme responsible for most of the replicative synthesis in bacteria. The enzyme also has 3' to 5' exonuclease activity. It has a core compos... | [
"GO:0003887",
"GO:0008408",
"GO:0006260"
] | [
"DNA-directed DNA polymerase activity",
"3'-5' exonuclease activity",
"DNA replication"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00678"
] | [
"holB"
] | [
12076
] | 1 | [
"EC",
"GP"
] | [
"2.7.7.7",
"GenProp0263"
] | [
"EC:2.7.7.7",
"GP:GenProp0263"
] | 2 | [
"1a5t",
"1jr3",
"1xxh",
"1xxi",
"3glf",
"3glg",
"3glh",
"3gli",
"8giy",
"8giz",
"8gj0",
"8gj1",
"8gj2",
"8gj3",
"8val",
"8vam",
"8van",
"8vap",
"8vaq",
"8var",
"8vas",
"8vat"
] | 22 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
11914,
2,
160
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | DNA polymerase III, delta prime subunit | DNA polymerase III, delta prime subunit | DNA_pol_HolB | 7 |
IPR004623 | 4,623 | Potassium-transporting ATPase A chain | KdpA | Family | 13,366 | false | false | Kdp is a high affinity ATP-driven K+ transport system in Escherichia coli. It is a membrane complex (KdpFABC) composed of four subunits, KdpA, KdpB, KdpC and KdpF, although KdpF is not present in some species [ ]. It maintains intracellular homeostasis, cell shape and turgor under potassium-limiting conditions. KdpA is... | [
"GO:0008556",
"GO:0006813"
] | [
"P-type potassium transmembrane transporter activity",
"potassium ion transport"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"PFAM",
"PIRSF",
"PANTHER",
"NCBIFAM"
] | [
"MF_00275",
"PF03814",
"PIRSF001294",
"PTHR30607",
"TIGR00680"
] | [
"KdpA",
"KdpA",
"K_ATPaseA",
"",
"kdpA"
] | [
12630,
13366,
12593,
13317,
12647
] | 5 | [
"GP"
] | [
"GenProp0172"
] | [
"GP:GenProp0172"
] | 1 | [
"5mrw",
"6hra",
"6hrb",
"7bgy",
"7bh1",
"7bh2",
"7lc3",
"7lc6",
"7nnl",
"7nnp",
"7zrd",
"7zre",
"7zrg",
"7zrh",
"7zri",
"7zrj",
"7zrk",
"7zrl",
"7zrm",
"9oc4"
] | 20 | [
"PUB00008269",
"PUB00099204"
] | [
"9858692",
"28636601"
] | [
"Assembly of the Kdp complex, the multi-subunit K+-transport ATPase of Escherichia coli.",
"Crystal structure of the potassium-importing KdpFABC membrane complex."
] | [
1998,
2017
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
85,
13163,
11,
107
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Potassium-transporting ATPase A chain | Potassium-transporting ATPase A chain | KdpA | 9 |
IPR004624 | 4,624 | Protein YjdM | YjdM | Family | 8,721 | false | false | The function of YjdM is not clear. It is not involved in phosphonate metabolism [ ]. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR00686"
] | [
"phnA"
] | [
8721
] | 1 | [
"EC"
] | [
"3.11.1.2"
] | [
"EC:3.11.1.2"
] | 1 | [
"2akl"
] | 1 | [
"PUB00043019"
] | [
"8335257"
] | [
"Evidence for a fourteen-gene, phnC to phnP locus for phosphonate metabolism in Escherichia coli."
] | [
1993
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
8626,
13,
82
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Protein YjdM | Protein YjdM | YjdM | 6 |
IPR004625 | 4,625 | Pyridoxine kinase | PyrdxlKinase | Family | 15,687 | false | false | Pyridoxal phosphate is the active form of vitamin B6 (pyridoxine or pyridoxal). Pyridoxal 5'-phosphate (PLP) is a versatile catalyst, acting as a coenzyme in a multitude of reactions, including decarboxylation, deamination and transamination [ , , ]. PLP-dependent enzymes are primarily involved in the biosynthesis of a... | [
"GO:0008478",
"GO:0009443"
] | [
"pyridoxal kinase activity",
"pyridoxal 5'-phosphate salvage"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PANTHER",
"NCBIFAM",
"CDD"
] | [
"PTHR10534",
"TIGR00687",
"cd01173"
] | [
"",
"pyridox_kin",
"pyridoxal_pyridoxamine_kinase"
] | [
15398,
11338,
13660
] | 3 | [
"EC",
"GP",
"GP",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.1.35",
"GenProp1218",
"GenProp1604",
"PWY-7204",
"PWY-7282",
"R-BTA-6798695",
"R-BTA-964975",
"R-CEL-6798695",
"R-CEL-964975",
"R-DDI-6798695",
"R-DDI-964975",
"R-HSA-6798695",
"R-HSA-964975",
"R-MMU-6798695",
"R-MMU-964975",
"R-RNO-6798695",
"R-RNO-964975",
"R-SCE-6798695",
... | [
"EC:2.7.1.35",
"GP:GenProp1218",
"GP:GenProp1604",
"METACYC:PWY-7204",
"METACYC:PWY-7282",
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-964975",
"REACTOME:R-CEL-6798695",
"REACTOME:R-CEL-964975",
"REACTOME:R-DDI-6798695",
"REACTOME:R-DDI-964975",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-964975... | 21 | [
"1lhp",
"1lhr",
"1rft",
"1rfu",
"1rfv",
"1td2",
"1vi9",
"1ygj",
"1ygk",
"1yhj",
"2ajp",
"2ddm",
"2ddo",
"2ddw",
"2f7k",
"2yxt",
"2yxu",
"3fhx",
"3fhy",
"3h74",
"3hyo",
"3ibq",
"3keu",
"3mbh",
"3mbj",
"3pzs",
"3zs7",
"4en4",
"4eoh",
"4s1h",
"4s1i",
"4s1m"... | 47 | [
"PUB00006322",
"PUB00017544",
"PUB00035504",
"PUB00035505",
"PUB00035506",
"PUB00035507",
"PUB00035508"
] | [
"7748903",
"9537380",
"15581583",
"8690703",
"15189147",
"17109392",
"16763894"
] | [
"Pyridoxal phosphate-dependent enzymes.",
"Identification and function of the pdxY gene, which encodes a novel pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate biosynthesis in Escherichia coli K-12.",
"Reaction specificity in pyridoxal phosphate enzymes.",
"Pyridoxal enzymes: mechani... | [
1995,
1998,
2005,
1995,
2004,
2006,
2006
] | 7 | [] | [
"IPR023479",
"IPR023685"
] | 0 | 2 | 0 | [
"Bacteria",
"Eukaryota",
"Methanobacteriati",
"unclassified sequences"
] | [
10056,
5580,
14,
37
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
3,
3,
8,
3,
2,
5,
1,
1,
4,
11,
2,
2,
8
] | 13 | true | Family | Pyridoxine kinase | Pyridoxine kinase | PyrdxlKinase | 5 |
IPR004627 | 4,627 | L-threonine 3-dehydrogenase | L-Threonine_3-DHase | Family | 5,655 | false | false | L-threonine 3-dehydrogenase is a tetrameric, zinc-binding, NAD-dependent enzyme involved in threonine catabolism. It catalyses the conversion of L-threonine and NAD(+) to L-2-amino-3-oxobutanoate and NADH. In Escherichia coli His-90 modulates substrate specificity and is believed to be part of the active site. Closely ... | [
"GO:0008270",
"GO:0008743",
"GO:0006567"
] | [
"zinc ion binding",
"L-threonine 3-dehydrogenase activity",
"L-threonine catabolic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_00627",
"TIGR00692"
] | [
"Thr_dehydrog",
"tdh"
] | [
5373,
4863
] | 2 | [
"EC",
"GP",
"METACYC"
] | [
"1.1.1.103",
"GenProp1646",
"PWY-7378"
] | [
"EC:1.1.1.103",
"GP:GenProp1646",
"METACYC:PWY-7378"
] | 3 | [
"2d8a",
"2dfv",
"2dq4",
"2ejv",
"3gfb",
"5kia"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
43,
5555,
15,
42
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | L-threonine 3-dehydrogenase | L-threonine 3-dehydrogenase | L-Threonine_3-DHase | 7 |
IPR004628 | 4,628 | Mannonate dehydratase | Man_deHydtase | Family | 10,265 | false | false | This Fe2+-requiring enzyme plays a role in D-glucuronate catabolism in Escherichia coli. Mannonate dehydratase converts D-mannonate to 2-dehydro-3-deoxy-D-gluconate. An apparent equivalog is found in a glucuronate utilization operon in Bacillus stearothermophilus T-6. | [
"GO:0008927",
"GO:0006064"
] | [
"mannonate dehydratase activity",
"glucuronate catabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"NCBIFAM",
"PFAM",
"PIRSF",
"PANTHER",
"NCBIFAM"
] | [
"MF_00106",
"NF003027",
"PF03786",
"PIRSF016049",
"PTHR30387",
"TIGR00695"
] | [
"UxuA",
"PRK03906.1",
"UxuA",
"Man_dehyd",
"",
"uxuA"
] | [
8388,
8530,
10265,
8775,
10195,
8194
] | 6 | [
"EC",
"GP",
"METACYC"
] | [
"4.2.1.8",
"GenProp1449",
"PWY-7242"
] | [
"EC:4.2.1.8",
"GP:GenProp1449",
"METACYC:PWY-7242"
] | 3 | [
"1tz9",
"3ban",
"3bdk",
"3dbn",
"3fvm",
"4eac",
"4eay"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
240,
9795,
64,
166
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Mannonate dehydratase | Mannonate dehydratase | Man_deHydtase | 9 |
IPR004629 | 4,629 | Glycosyl transferase WecG/TagA/CpsF | WecG_TagA_CpsF | Family | 15,326 | false | false | The WecG member of this family, believed to be UDP-N-acetyl-D-mannosaminuronic acid transferase, plays a role in enterobacterial common antigen (eca) synthesis in Escherichia coli. Another family member, the Bacillus subtilis TagA protein, is involved in the biosynthesis of the cell wall polymer poly(glycerol phosphate... | [
"GO:0016740",
"GO:0009058"
] | [
"transferase activity",
"biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PANTHER",
"NCBIFAM",
"CDD"
] | [
"PF03808",
"PTHR34136",
"TIGR00696",
"cd06533"
] | [
"Glyco_tran_WecG",
"",
"wecG_tagA_cpsF",
"Glyco_transf_WecG_TagA"
] | [
15312,
15047,
14205,
14698
] | 4 | [
"EC",
"GP",
"GP",
"GP"
] | [
"2.4.1.180",
"GenProp1270",
"GenProp1398",
"GenProp1756"
] | [
"EC:2.4.1.180",
"GP:GenProp1270",
"GP:GenProp1398",
"GP:GenProp1756"
] | 4 | [
"5wb4",
"5wfg",
"7mpk",
"7n41"
] | 4 | [
"PUB00012908",
"PUB00017552",
"PUB00042826",
"PUB00072175",
"PUB00079558",
"PUB00079559",
"PUB00079560"
] | [
"11673418",
"8830246",
"9537354",
"18156271",
"12618464",
"16953575",
"3275612"
] | [
"Identification of the structural gene for the TDP-Fuc4NAc:lipid II Fuc4NAc transferase involved in synthesis of enterobacterial common antigen in Escherichia coli K-12.",
"Characterization of cpsF and its product CMP-N-acetylneuraminic acid synthetase, a group B streptococcal enzyme that can function in K1 capsu... | [
2001,
1996,
1998,
2008,
2003,
2006,
1988
] | 7 | [] | [
"IPR023085",
"IPR034714"
] | 0 | 2 | 0 | [
"Bacteria",
"Eukaryota",
"Ignicoccus islandicus DSM 13165",
"metagenomes"
] | [
15165,
12,
1,
148
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Glycosyl transferase WecG/TagA/CpsF | Glycosyl transferase WecG/TagA/CpsF | WecG_TagA_CpsF | 3 |
IPR004630 | 4,630 | UPF0324 inner membrane protein YeiH-like | UPF0324_YeiH-like | Family | 3,228 | false | false | This entry represents a family of uncharacterised multi-pass membrane proteins, which are found in both Gram-positive and Gram-negative species, such as YeiH from E. coli. Members of this family are found so far only in one archaeal species, Archaeoglobus fulgidus. These proteins have a molecular weight of approximatel... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"NCBIFAM"
] | [
"TIGR00698"
] | [
""
] | [
3228
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR018383"
] | [] | 1 | 0 | 1 | [
"Archaeoglobus fulgidus",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
4,
3182,
7,
35
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | UPF0324 inner membrane protein YeiH-like | UPF0324 inner membrane protein YeiH-like | UPF0324_YeiH-like | 2 |
IPR004631 | 4,631 | 4-aminobutyrate aminotransferase, eukaryotic | 4NH2But_aminotransferase_euk | Family | 3,626 | false | false | 4-aminobutyrate aminotransferase eukaryotic ( ) is a class III pyridoxal-phosphate-dependent aminotransferase. The enzyme catalyses the conversion of 4-aminobutanoate and 2-oxoglutarate into succinate semialdehyde and L-glutamate. The degree of sequence difference between this set and known bacterial examples is greate... | [
"GO:0034386",
"GO:0009448"
] | [
"4-aminobutyrate:2-oxoglutarate transaminase activity",
"gamma-aminobutyric acid metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00699"
] | [
"GABAtrns_euk"
] | [
3626
] | 1 | [
"EC",
"GP",
"GP",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.6.1.19",
"GenProp0233",
"GenProp1288",
"GenProp1506",
"GenProp1523",
"PWY-5022",
"PWY-6535",
"PWY-6536",
"PWY-6537",
"PWY-8346",
"R-CEL-916853",
"R-DDI-916853",
"R-HSA-916853",
"R-MMU-916853",
"R-RNO-916853",
"R-SCE-916853",
"R-SPO-916853",
"R-SSC-916853"
] | [
"EC:2.6.1.19",
"GP:GenProp0233",
"GP:GenProp1288",
"GP:GenProp1506",
"GP:GenProp1523",
"METACYC:PWY-5022",
"METACYC:PWY-6535",
"METACYC:PWY-6536",
"METACYC:PWY-6537",
"METACYC:PWY-8346",
"REACTOME:R-CEL-916853",
"REACTOME:R-DDI-916853",
"REACTOME:R-HSA-916853",
"REACTOME:R-MMU-916853",
"... | 18 | [
"1ohv",
"1ohw",
"1ohy",
"4y0d",
"4y0h",
"4y0i",
"4zsw",
"4zsy",
"6b6g"
] | 9 | [] | [] | [] | [] | 0 | [
"IPR005814"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
3626
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
1,
4,
2,
5,
2,
2,
3,
1,
1
] | 9 | true | Family | 4-aminobutyrate aminotransferase, eukaryotic | 4-aminobutyrate aminotransferase, eukaryotic | 4NH2But_aminotransferase_euk | 1 |
IPR004633 | 4,633 | Na/Pi-cotransporter II-related/YqeW-like protein | NaPi_cotrn-rel/YqeW-like | Family | 8,307 | false | false | This family describes essentially the full length of an uncharacterised protein from Bacillus subtilis (YqeW) and corresponding lengths of longer proteins from Escherichia coli and Treponema pallidum. There is homology to one other group of proteins, type II sodium/phosphate (Na/Pi) cotransporters. A well-conserved rep... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"NCBIFAM"
] | [
"TIGR00704"
] | [
"NaPi_cotrn_rel"
] | [
8307
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR003841"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
23,
8234,
3,
47
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Na/Pi-cotransporter II-related/YqeW-like protein | Na/Pi-cotransporter II-related/YqeW-like protein | NaPi_cotrn-rel/YqeW-like | 2 |
IPR004634 | 4,634 | Peptidase S49, protease IV | Pept_S49_pIV | Family | 8,862 | false | false | This group of serine peptidases belong to MEROPS peptidase family S49 (protease IV family, clan S-). The predicted active site serine for members of this family occurs in a transmembrane domain. Signal peptides of secretory proteins seem to serve at least two important biological functions. First, they are required for... | [
"GO:0008233",
"GO:0006465",
"GO:0016020"
] | [
"peptidase activity",
"signal peptide processing",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PIRSF",
"NCBIFAM"
] | [
"PIRSF001217",
"TIGR00705"
] | [
"Protease_4_SppA",
"SppA_67K"
] | [
8611,
7799
] | 2 | [
"EC",
"GP",
"METACYC"
] | [
"3.4.21.-",
"GenProp1327",
"PWY-7884"
] | [
"EC:3.4.21.-",
"GP:GenProp1327",
"METACYC:PWY-7884"
] | 3 | [
"3bez",
"3bf0"
] | 2 | [
"PUB00000522",
"PUB00003576",
"PUB00007689",
"PUB00081439"
] | [
"8439290",
"7845208",
"10455123",
"18476724"
] | [
"Evolutionary families of peptidases.",
"Families of serine peptidases.",
"Signal peptide peptidase- and ClpP-like proteins of Bacillus subtilis required for efficient translocation and processing of secretory proteins.",
"Escherichia coli signal peptide peptidase A is a serine-lysine protease with a lysine r... | [
1993,
1994,
1999,
2008
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
8351,
443,
1,
67
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
3,
1,
3,
4
] | 4 | true | Family | Peptidase S49, protease IV | Peptidase S49, protease IV | Pept_S49_pIV | 1 |
IPR004635 | 4,635 | Peptidase S49, SppA | Pept_S49_SppA | Domain | 15,522 | false | false | This group of serine peptidases belong to MEROPS peptidase family S49 (protease IV family, clan S-). The predicted active site serine for members of this family occurs in a transmembrane domain. This group of sequences represent both long and short forms of the bacterial SppA and homologues found in the archaea and pla... | [
"GO:0008233",
"GO:0006508"
] | [
"peptidase activity",
"proteolysis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00706"
] | [
"SppA_dom"
] | [
15522
] | 1 | [
"EC",
"METACYC"
] | [
"3.4.21.-",
"PWY-7884"
] | [
"EC:3.4.21.-",
"METACYC:PWY-7884"
] | 2 | [
"3bez",
"3bf0",
"3rst",
"4kwb"
] | 4 | [
"PUB00000522",
"PUB00003576",
"PUB00007689"
] | [
"8439290",
"7845208",
"10455123"
] | [
"Evolutionary families of peptidases.",
"Families of serine peptidases.",
"Signal peptide peptidase- and ClpP-like proteins of Bacillus subtilis required for efficient translocation and processing of secretory proteins."
] | [
1993,
1994,
1999
] | 3 | [
"IPR002142"
] | [
"IPR033854"
] | 1 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
552,
13904,
749,
146,
171
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
2,
1,
3,
4
] | 4 | true | Domain | Peptidase S49, SppA | Peptidase S49, SppA | Pept_S49_SppA | 4 |
IPR004636 | 4,636 | Acetylornithine/Succinylornithine transaminase family | AcOrn/SuccOrn_fam | Family | 25,536 | false | false | This family of proteins, for which ornithine aminotransferases form an outgroup, consists mostly of proteins designated acetylornithine aminotransferase. However, the two very closely related members from Escherichia coli are assigned different enzymatic activities. One is acetylornithine aminotransferase ( ), ArgD, an... | [
"GO:0008483",
"GO:0006525"
] | [
"transaminase activity",
"arginine metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_01107",
"TIGR00707"
] | [
"ArgD_aminotrans_3",
"argD"
] | [
23233,
24794
] | 2 | [
"EC",
"EC",
"GP",
"GP",
"GP",
"GP",
"METACYC"
] | [
"2.6.1",
"2.6.1.11",
"GenProp0118",
"GenProp0193",
"GenProp1280",
"GenProp1466",
"PWY-5154"
] | [
"EC:2.6.1",
"EC:2.6.1.11",
"GP:GenProp0118",
"GP:GenProp0193",
"GP:GenProp1280",
"GP:GenProp1466",
"METACYC:PWY-5154"
] | 7 | [
"1vef",
"1wkg",
"1wkh",
"2e54",
"2eh6",
"2ord",
"2pb0",
"2pb2",
"3nx3",
"4adb",
"4adc",
"4add",
"4ade",
"4jev",
"4jew",
"4jex",
"4jey",
"4jez",
"4jf0",
"4jf1",
"6w7x",
"7nn1",
"7nn4",
"7nnc",
"8ht2",
"8ht4"
] | 26 | [
"PUB00008006",
"PUB00008007",
"PUB00008008"
] | [
"9696779",
"2199330",
"10074354"
] | [
"Arginine catabolism and the arginine succinyltransferase pathway in Escherichia coli.",
"Escherichia coli and Saccharomyces cerevisiae acetylornithine aminotransferase: evolutionary relationship with ornithine aminotransferase.",
"The dual biosynthetic capability of N-acetylornithine aminotransferase in argini... | [
1998,
1990,
1999
] | 3 | [
"IPR005814"
] | [
"IPR017652"
] | 1 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
512,
22364,
2312,
348
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
4,
2,
1,
1,
1,
1,
2
] | 7 | true | Family | Acetylornithine/Succinylornithine transaminase family | Acetylornithine/Succinylornithine transaminase family | AcOrn/SuccOrn_fam | 9 |
IPR004637 | 4,637 | 2,4-diaminobutyrate 4-transaminase | Dat | Family | 9,450 | false | false | This family consists of L-diaminobutyric acid transaminases. This general designation covers both (diaminobutyrate-2-oxoglutarate transaminase, which uses glutamate as the amino donor in DABA biosynthesis), and (diaminobutyrate--pyruvate transaminase, which uses alanine as the amino donor). Most members with known func... | [
"GO:0008483",
"GO:0009058"
] | [
"transaminase activity",
"biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PANTHER",
"NCBIFAM"
] | [
"PTHR43552",
"TIGR00709"
] | [
"",
"dat"
] | [
9447,
8597
] | 2 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.6.1.76",
"PWY-6409",
"PWY-6562",
"PWY-761",
"PWY-7855",
"PWY-7988"
] | [
"EC:2.6.1.76",
"METACYC:PWY-6409",
"METACYC:PWY-6562",
"METACYC:PWY-761",
"METACYC:PWY-7855",
"METACYC:PWY-7988"
] | 6 | [
"6rl5"
] | 1 | [] | [] | [] | [] | 0 | [
"IPR005814"
] | [
"IPR012773"
] | 1 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
152,
9246,
22,
30
] | 4 | [] | [] | 0 | true | Family | 2,4-diaminobutyrate 4-transaminase | 2,4-diaminobutyrate 4-transaminase | Dat | 5 |
IPR004638 | 4,638 | Drug resistance transporter EmrB-like | EmrB-like | Family | 84,261 | false | false | This subfamily of drug efflux proteins, a part of the major facilitator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in Escherichia coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae [ ], Tcm... | [
"GO:0022857",
"GO:0055085",
"GO:0016020"
] | [
"transmembrane transporter activity",
"transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00711"
] | [
"efflux_EmrB"
] | [
84261
] | 1 | [] | [] | [] | 0 | [
"8zal",
"8zar"
] | 2 | [
"PUB00082582",
"PUB00158923"
] | [
"25938806",
"10447892"
] | [
"Extensive Identification of Bacterial Riboflavin Transporters and Their Distribution across Bacterial Species.",
"The farAB-encoded efflux pump mediates resistance of gonococci to long-chained antibacterial fatty acids."
] | [
2015,
1999
] | 2 | [
"IPR011701"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
214,
83155,
400,
492
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)"
] | [
1,
4
] | 2 | true | Family | Drug resistance transporter EmrB-like | Drug resistance transporter EmrB-like | EmrB-like | 2 |
IPR004639 | 4,639 | Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase | 4pyrrol_synth_GluAld_NH2Trfase | Family | 22,369 | false | false | Tetrapyrroles are large macrocyclic compounds derived from a common biosynthetic pathway [ ]. The end-product, uroporphyrinogen III, is used to synthesise a number of important molecules, including vitamin B12, haem, sirohaem, chlorophyll, coenzyme F430 and phytochromobilin [ ]. The first stage in tetrapyrrole synthesi... | [
"GO:0042286",
"GO:0033014"
] | [
"glutamate-1-semialdehyde 2,1-aminomutase activity",
"tetrapyrrole biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"NCBIFAM",
"NCBIFAM"
] | [
"MF_00375",
"NF000818",
"TIGR00713"
] | [
"HemL_aminotrans_3",
"PRK00062.1",
"hemL"
] | [
21819,
22346,
20748
] | 3 | [
"EC",
"GP",
"GP",
"METACYC"
] | [
"5.4.3.8",
"GenProp0217",
"GenProp1701",
"PWY-5188"
] | [
"EC:5.4.3.8",
"GP:GenProp0217",
"GP:GenProp1701",
"METACYC:PWY-5188"
] | 4 | [
"2cfb",
"2e7u",
"2epj",
"2gsa",
"2hoy",
"2hoz",
"2hp1",
"2hp2",
"2zsl",
"2zsm",
"3bs8",
"3fq7",
"3fq8",
"3fqa",
"3gsb",
"3k28",
"3l44",
"3usf",
"4e77",
"4gsa",
"5hdm",
"5i92",
"6w80"
] | 23 | [
"PUB00009744",
"PUB00023085",
"PUB00035496",
"PUB00035498",
"PUB00035499"
] | [
"11215515",
"9144156",
"17227226",
"16564539",
"15890644"
] | [
"Biosynthesis of cobalamin (vitamin B12): a bacterial conundrum.",
"Crystal structure of glutamate-1-semialdehyde aminomutase: an alpha2-dimeric vitamin B6-dependent enzyme with asymmetry in structure and active site reactivity.",
"Tetrapyrrole biosynthesis in higher plants.",
"Evolutionary relationship betwe... | [
2000,
1997,
2007,
2006,
2005
] | 5 | [
"IPR005814"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
806,
20347,
931,
285
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
8,
1,
1,
4
] | 4 | true | Family | Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase | Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase | 4pyrrol_synth_GluAld_NH2Trfase | 8 |
IPR004641 | 4,641 | Ribonuclease HIII | RNase_HIII | Family | 2,637 | false | false | This family describes bacterial RNase HIII. Ribonuclease HIII cleaves RNA from DNA-RNA hybrids. It catalyses endonucleolytic cleavage to 5'-phospho-monoesters. Two types of ribonuclease H in Bacillus subtilis, RNase HII (rnhB) and RNase HIII (rnhC), are both known experimentally and are quite similar to each other. The... | [
"GO:0004523",
"GO:0016070",
"GO:0005737"
] | [
"RNA-DNA hybrid ribonuclease activity",
"RNA metabolic process",
"cytoplasm"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"HAMAP",
"PIRSF",
"NCBIFAM"
] | [
"MF_00053",
"PIRSF037748",
"TIGR00716"
] | [
"RNase_HIII",
"RnhC",
"rnhC"
] | [
2278,
2424,
2617
] | 3 | [
"EC"
] | [
"3.1.26.4"
] | [
"EC:3.1.26.4"
] | 1 | [
"2d0a",
"2d0b",
"2d0c",
"3asm",
"3vn5",
"4py5"
] | 6 | [
"PUB00014832"
] | [
"9888800"
] | [
"Identification of the genes encoding Mn2+-dependent RNase HII and Mg2+-dependent RNase HIII from Bacillus subtilis: classification of RNases H into three families."
] | [
1999
] | 1 | [
"IPR001352"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Methanobacteriota",
"Potamilus streckersoni",
"metagenomes"
] | [
2611,
12,
1,
13
] | 4 | [] | [] | 0 | true | Family | Ribonuclease HIII | Ribonuclease HIII | RNase_HIII | 9 |
IPR004642 | 4,642 | Serine dehydratase, alpha subunit | Ser_deHydtase_asu | Family | 4,907 | false | false | L-serine dehydratase converts serine into pyruvate in the gluconeogenesis pathway from serine. This model describes the alpha chain of an iron-sulphur-dependent L-serine dehydratase, found in Bacillus subtilis. A fairly deep split in a UPGMA tree separates members of this family of alpha chains from the homologous regi... | [
"GO:0003941",
"GO:0006094"
] | [
"L-serine ammonia-lyase activity",
"gluconeogenesis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00718"
] | [
"sda_alpha"
] | [
4907
] | 1 | [
"EC"
] | [
"4.3.1.17"
] | [
"EC:4.3.1.17"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR051318"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
7,
4877,
4,
19
] | 4 | [] | [] | 0 | true | Family | Serine dehydratase, alpha subunit | Serine dehydratase, alpha subunit | Ser_deHydtase_asu | 8 |
IPR004643 | 4,643 | Iron-sulphur-dependent L-serine dehydratase beta subunit | Fe-S_L-Ser_bsu | Family | 4,626 | false | false | L-serine dehydratase, also called serine deaminase, catalyses the conversion of L-serine and water to pyruvate and ammonia during gluconeogenesis from serine. The enzyme forms a heterooctamer of four alpha chains and four beta chains. This family describes the beta chain of an iron-sulphur-dependent L-serine dehydratas... | [
"GO:0003941",
"GO:0006094"
] | [
"L-serine ammonia-lyase activity",
"gluconeogenesis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF",
"NCBIFAM"
] | [
"PIRSF036692",
"TIGR00719"
] | [
"SDH_B",
"sda_beta"
] | [
4361,
4542
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR051318"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
5,
4600,
2,
19
] | 4 | [] | [] | 0 | true | Family | Iron-sulphur-dependent L-serine dehydratase beta subunit | Iron-sulphur-dependent L-serine dehydratase beta subunit | Fe-S_L-Ser_bsu | 6 |
IPR004644 | 4,644 | Iron-sulphur-dependent L-serine dehydratase single chain form | Fe-S_L-Ser_mono | Family | 18,723 | false | false | This enzyme is also called serine deaminase. L-serine dehydratase converts serine into pyruvate in the gluconeogenesis pathway from serine. This enzyme is comprised of a single chain in Escherichia coli, Mycobacterium tuberculosis, and several other species, but has separate alpha and beta chains in Bacillus subtilis a... | [
"GO:0003941",
"GO:0006094"
] | [
"L-serine ammonia-lyase activity",
"gluconeogenesis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00720"
] | [
"sda_mono"
] | [
18723
] | 1 | [
"EC"
] | [
"4.3.1.17"
] | [
"EC:4.3.1.17"
] | 1 | [
"4rqo"
] | 1 | [
"PUB00016056",
"PUB00077265"
] | [
"9484901",
"15498577"
] | [
"Novel keto acid formate-lyase and propionate kinase enzymes are components of an anaerobic pathway in Escherichia coli that degrades L-threonine to propionate.",
"The iron-sulfur cluster in the L-serine dehydratase TdcG from Escherichia coli is required for enzyme activity."
] | [
1998,
2004
] | 2 | [
"IPR051318"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Methanococcus voltae",
"unclassified sequences"
] | [
18443,
189,
3,
88
] | 4 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Family | Iron-sulphur-dependent L-serine dehydratase single chain form | Iron-sulphur-dependent L-serine dehydratase single chain form | Fe-S_L-Ser_mono | 9 |
IPR004645 | 4,645 | DNA-binding protein Tfx, archaea | Tfx_DNA-bd_arc | Family | 503 | false | false | This entry represents a family of Tfx DNA-binding proteins, which is restricted to the archaea. TfX has a 2-layer α/β topology. Homology among the members is strongest in the helix-turn-helix-containing N-terminal region. Tfx from Methanothermobacter thermautotrophicus (Methanobacterium thermoformicicum) is associated ... | [
"GO:0003677"
] | [
"DNA binding"
] | [
"molecular_function"
] | 1 | [
"NCBIFAM"
] | [
"TIGR00721"
] | [
"tfx"
] | [
503
] | 1 | [] | [] | [] | 0 | [
"1nr3",
"8hno",
"8hnp"
] | 3 | [] | [] | [] | [] | 0 | [] | [
"IPR018384"
] | 0 | 1 | 0 | [
"Archaea",
"ecological metagenomes"
] | [
499,
4
] | 2 | [] | [] | 0 | true | Family | DNA-binding protein Tfx, archaea | DNA-binding protein Tfx, archaea | Tfx_DNA-bd_arc | 9 |
IPR004646 | 4,646 | Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain | Fe-S_hydro-lyase_TtdA-typ_cat | Domain | 19,368 | false | false | This entry represents various Fe-S type hydro-lyases, including the alpha subunit from both L-tartrate dehydratase (TtdA; ) and class 1 fumarate hydratases ( ), which includes both aerobic (FumA) and anaerobic (FumB) types [ ]. A number of Fe-S cluster-containing hydro-lyases share a conserved motif, including arginino... | [
"GO:0016829"
] | [
"lyase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"NCBIFAM"
] | [
"PF05681",
"TIGR00722"
] | [
"Fumerase",
"ttdA_fumA_fumB"
] | [
19368,
16882
] | 2 | [
"EC",
"GP"
] | [
"4.2.1",
"GenProp0033"
] | [
"EC:4.2.1",
"GP:GenProp0033"
] | 2 | [
"5l2r",
"6msn",
"6mso",
"6unz",
"6uo0",
"6uoi",
"6uoj",
"6up9",
"6upm",
"6upo",
"6uq8",
"6uq9",
"6uqb",
"6uql",
"6uqm",
"6uqn",
"7xky"
] | 17 | [
"PUB00011340",
"PUB00053405"
] | [
"11133938",
"8371115"
] | [
"Oxygen- and growth rate-dependent regulation of Escherichia coli fumarase (FumA, FumB, and FumC) activity.",
"Identification of the L-tartrate dehydratase genes (ttdA and ttdB) of Escherichia coli and evolutionary relationship with the class I fumarase genes."
] | [
2001,
1993
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
430,
17893,
588,
1,
456
] | 5 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Domain | Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain | Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain | Fe-S_hydro-lyase_TtdA-typ_cat | 6 |
IPR004647 | 4,647 | Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain | Fe-S_hydro-lyase_TtdB-typ_cat | Domain | 18,893 | false | false | This entry represents various Fe-S type hydro-lyases, including the beta subunit from both L-tartrate dehydratase (TtdB; ) and class 2 fumarate hydratase (FumC; ) [ ]. A number of Fe-S cluster-containing hydro-lyases share a conserved motif, including argininosuccinate lyase, adenylosuccinate lyase, aspartase, class I ... | [
"GO:0016836"
] | [
"hydro-lyase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"NCBIFAM"
] | [
"PF05683",
"TIGR00723"
] | [
"Fumerase_C",
"ttdB_fumA_fumB"
] | [
18893,
17814
] | 2 | [
"EC",
"GP"
] | [
"4.2.1",
"GenProp0033"
] | [
"EC:4.2.1",
"GP:GenProp0033"
] | 2 | [
"2isb",
"5dni",
"5l2r",
"6msn",
"6mso",
"6unz",
"6uo0",
"6uoi",
"6uoj",
"6up9",
"6upm",
"6upo",
"6uq8",
"6uq9",
"6uqb",
"6uql",
"6uqm",
"6uqn",
"7xky"
] | 19 | [
"PUB00053406"
] | [
"15803386"
] | [
"Molecular cloning and functional characterization of fumarases C in Neisseria species."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
426,
17443,
580,
1,
443
] | 5 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Domain | Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain | Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain | Fe-S_hydro-lyase_TtdB-typ_cat | 3 |
IPR004648 | 4,648 | Tetrapeptide transporter, OPT1/isp4 | Oligpept_transpt | Family | 21,557 | false | false | Oligopeptide transporter OPT superfamily has two main branches. One branch contains a tetrapeptide transporter demonstrated experimentally in three different species of yeast. The other family contains EspB, a protein required for normal rather than delayed sporulation after cellular aggregation; its role is unknown bu... | [
"GO:0055085"
] | [
"transmembrane transport"
] | [
"biological_process"
] | 1 | [
"PANTHER",
"NCBIFAM"
] | [
"PTHR22601",
"TIGR00727"
] | [
"",
"ISP4_OPT"
] | [
21554,
13467
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR004813"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
21557
] | 1 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
40,
9,
38,
2,
3,
46
] | 6 | true | Family | Tetrapeptide transporter, OPT1/isp4 | Tetrapeptide transporter, OPT1/isp4 | Oligpept_transpt | 9 |
IPR004649 | 4,649 | Ribonuclease H2, subunit A | RNase_H2_suA | Family | 4,513 | false | false | Whereas bacterial and archaeal RNases H2 are active as single polypeptides, the Saccharomyces cerevisiae (Baker's yeast) homologue, Rnh2Ap, when expressed in Escherichia coli, fails to produce an active RNase H2. For RNase H2 activity three proteins are required [Rnh2Ap (Rnh201p), Ydr279p (Rnh202p) and Ylr154p (Rnh203p... | [
"GO:0004523",
"GO:0016070"
] | [
"RNA-DNA hybrid ribonuclease activity",
"RNA metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00729"
] | [
""
] | [
4513
] | 1 | [
"EC"
] | [
"3.1.26.4"
] | [
"EC:3.1.26.4"
] | 1 | [
"1eke",
"1i39",
"1i3a",
"1io2",
"1uax",
"1x1p",
"2dfe",
"2dff",
"2dfh",
"3kio",
"3p56",
"3p5j",
"3p83",
"3puf",
"8yjz"
] | 15 | [
"PUB00044465"
] | [
"14734815"
] | [
"RNase H2 of Saccharomyces cerevisiae is a complex of three proteins."
] | [
2004
] | 1 | [
"IPR001352"
] | [
"IPR020787"
] | 1 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Megaviricetes",
"unclassified sequences"
] | [
923,
19,
3529,
3,
39
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
1,
1,
11,
3,
3,
1,
2,
4,
1,
1,
6
] | 12 | true | Family | Ribonuclease H2, subunit A | Ribonuclease H2, subunit A | RNase_H2_suA | 7 |
IPR004650 | 4,650 | HisA/HisF-like protein, archaeal | HisA/F-archaeal | Family | 107 | false | false | This family of proteins has so far been found in three archaeal species: Methanothermobacter thermautotrophicus (Methanobacterium thermoformicicum), Methanocaldococcus jannaschii (Methanococcus jannaschii), and Archaeoglobus fulgidus. Proteins are homologous to phosphoribosylformimino-5-aminoimidazole carboxamide ribot... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR00734"
] | [
"hisAF_rel"
] | [
107
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR006062"
] | [] | 1 | 0 | 1 | [
"Methanobacteriota",
"bioreactor metagenome"
] | [
106,
1
] | 2 | [] | [] | 0 | true | Family | HisA/HisF-like protein, archaeal | HisA/HisF-like protein, archaeal | HisA/F-archaeal | 6 |
IPR004651 | 4,651 | Histidine biosynthesis, HisF | HisF | Family | 26,603 | false | false | Histidine is formed by several complex and distinct biochemical reactions catalysed by eight enzymes. Proteins involved in steps 4 and 6 of the histidine biosynthesis pathway are contained in one family. These enzymes are called His6 and His7 in eukaryotes and HisA and HisF in prokaryotes [ , , ]. HisA is a phosphoribo... | [
"GO:0000107",
"GO:0000105"
] | [
"imidazoleglycerol-phosphate synthase activity",
"L-histidine biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"NCBIFAM",
"CDD"
] | [
"MF_01013",
"TIGR00735",
"cd04731"
] | [
"HisF",
"hisF",
"HisF"
] | [
22237,
24519,
26603
] | 3 | [
"EC",
"GP"
] | [
"4.3.2.10",
"GenProp0109"
] | [
"EC:4.3.2.10",
"GP:GenProp0109"
] | 2 | [
"1gpw",
"1h5y",
"1jvn",
"1ka9",
"1ox4",
"1ox5",
"1ox6",
"1thf",
"1vh7",
"2a0n",
"2rkx",
"2wjz",
"3iio",
"3iip",
"3iiv",
"3zr4",
"4evz",
"4ewn",
"4z08",
"5d2t",
"5d2v",
"5d2w",
"5d2x",
"5d2y",
"5d30",
"5d32",
"5d33",
"5d37",
"5d38",
"5tql",
"6c7h",
"6c7m"... | 52 | [
"PUB00021977",
"PUB00025531",
"PUB00039276",
"PUB00081035",
"PUB00081080",
"PUB00081081"
] | [
"12417026",
"11679715",
"16731983",
"12795596",
"16142895",
"15363855"
] | [
"Structure of imidazole glycerol phosphate synthase from Thermus thermophilus HB8: open-closed conformational change and ammonia tunneling.",
"Structure of HisF, a histidine biosynthetic protein from Pyrobaculum aerophilum.",
"Crystal structure of the yeast His6 enzyme suggests a reaction mechanism.",
"Substr... | [
2002,
2001,
2006,
2003,
2005,
2004
] | 6 | [
"IPR006062"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences",
"uncultured Caudovirales phage"
] | [
822,
22746,
2543,
491,
1
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
4,
1,
1,
3,
1,
1,
6
] | 7 | true | Family | Histidine biosynthesis, HisF | Histidine biosynthesis, HisF | HisF | 2 |
IPR004652 | 4,652 | tRNA-dihydrouridine synthase DusB-like | DusB-like | Family | 22,113 | false | false | This family represents tRNA-dihydrouridine synthases from the nifR3 family that includes NifR3 itself, from Rhodobacter capsulatus and DusB from E. coli [ ]. Members of this family catalyse the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in proka... | [
"GO:0016491",
"GO:0050660",
"GO:0008033"
] | [
"oxidoreductase activity",
"flavin adenine dinucleotide binding",
"tRNA processing"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00737"
] | [
"nifR3_yhdG"
] | [
22113
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"1.3.1.-",
"PWY-2541",
"PWY-5292",
"PWY-5301",
"PWY-5367",
"PWY-5393",
"PWY-5729",
"PWY-5818",
"PWY-5956",
"PWY-5972",
"PWY-5984",
"PWY-6088",
"PWY-6302",
"PWY-6309",
"PWY-6332",
"PWY-6786",
"PWY-6824",
"PWY-6944",
"PWY-6996",
"PWY-7096",
"PWY-7154",
"PWY-7155",
"PWY-7300... | [
"EC:1.3.1.-",
"METACYC:PWY-2541",
"METACYC:PWY-5292",
"METACYC:PWY-5301",
"METACYC:PWY-5367",
"METACYC:PWY-5393",
"METACYC:PWY-5729",
"METACYC:PWY-5818",
"METACYC:PWY-5956",
"METACYC:PWY-5972",
"METACYC:PWY-5984",
"METACYC:PWY-6088",
"METACYC:PWY-6302",
"METACYC:PWY-6309",
"METACYC:PWY-6... | 35 | [
"1vhn",
"6ei9"
] | 2 | [
"PUB00014304",
"PUB00106870"
] | [
"12003496",
"29294097"
] | [
"A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA.",
"Unveiling structural and functional divergences of bacterial tRNA dihydrouridine synthases: perspectives on the evolution scenario."
] | [
2002,
2018
] | 2 | [
"IPR001269"
] | [
"IPR032887"
] | 1 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
81,
21630,
43,
359
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | tRNA-dihydrouridine synthase DusB-like | tRNA-dihydrouridine synthase DusB-like | DusB-like | 7 |
IPR004653 | 4,653 | tRNA-dihydrouridine(20/20a) synthase | DusA | Family | 11,587 | false | false | Dihydrouridine (D) is a highly conserved modified base found in tRNAs from all domains of life. D is formed by reduction of the carbon-carbon double bond at positions 5 and 6 of the uridine base by dihydrouridine synthases (Dus), and is mostly found in the D-loop of tRNAs for which it is named [ ]. This entry represent... | [
"GO:0017150",
"GO:0002943"
] | [
"tRNA dihydrouridine synthase activity",
"tRNA dihydrouridine synthesis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"NCBIFAM",
"PANTHER",
"NCBIFAM"
] | [
"MF_02041",
"NF008774",
"PTHR42907",
"TIGR00742"
] | [
"DusA_subfam",
"PRK11815.1",
"",
"yjbN"
] | [
9336,
10823,
11583,
8464
] | 4 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"... | [
"1.3.1.-",
"1.3.1.91",
"PWY-2541",
"PWY-5292",
"PWY-5301",
"PWY-5367",
"PWY-5393",
"PWY-5729",
"PWY-5818",
"PWY-5956",
"PWY-5972",
"PWY-5984",
"PWY-6088",
"PWY-6302",
"PWY-6309",
"PWY-6332",
"PWY-6786",
"PWY-6824",
"PWY-6944",
"PWY-6996",
"PWY-7096",
"PWY-7154",
"PWY-7155... | [
"EC:1.3.1.-",
"EC:1.3.1.91",
"METACYC:PWY-2541",
"METACYC:PWY-5292",
"METACYC:PWY-5301",
"METACYC:PWY-5367",
"METACYC:PWY-5393",
"METACYC:PWY-5729",
"METACYC:PWY-5818",
"METACYC:PWY-5956",
"METACYC:PWY-5972",
"METACYC:PWY-5984",
"METACYC:PWY-6088",
"METACYC:PWY-6302",
"METACYC:PWY-6309",... | 36 | [
"3b0p",
"3b0u",
"3b0v"
] | 3 | [
"PUB00057678"
] | [
"22123979"
] | [
"Molecular basis of dihydrouridine formation on tRNA."
] | [
2011
] | 1 | [
"IPR001269"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Myoviridae sp. ct8aR17",
"unclassified sequences"
] | [
9668,
1796,
1,
122
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
11,
1,
7,
13
] | 4 | true | Family | tRNA-dihydrouridine(20/20a) synthase | tRNA-dihydrouridine(20/20a) synthase | DusA | 2 |
IPR004654 | 4,654 | Glucokinase ROK | ROK_glcA | Family | 7,915 | false | false | This family describes one branch of the ROK superfamily of proteins that may have activity as glucokinase. Glucokinase is required for glucose repression of many different genes [ , ]. | [
"GO:0004340",
"GO:0006096",
"GO:0051156",
"GO:0005737"
] | [
"glucokinase activity",
"glycolytic process",
"glucose 6-phosphate metabolic process",
"cytoplasm"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"NCBIFAM"
] | [
"TIGR00744"
] | [
"ROK_glcA_fam"
] | [
7915
] | 1 | [
"EC",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.7.1.2",
"GenProp1394",
"GenProp1599",
"PWY-2722",
"PWY-2723",
"PWY-5514",
"PWY-5661",
"PWY-5941",
"PWY-621",
"PWY-7238",
"PWY-7385"
] | [
"EC:2.7.1.2",
"GP:GenProp1394",
"GP:GenProp1599",
"METACYC:PWY-2722",
"METACYC:PWY-2723",
"METACYC:PWY-5514",
"METACYC:PWY-5661",
"METACYC:PWY-5941",
"METACYC:PWY-621",
"METACYC:PWY-7238",
"METACYC:PWY-7385"
] | 11 | [
"2qm1",
"3vgk",
"3vgl",
"3vgm"
] | 4 | [
"PUB00070835",
"PUB00070836"
] | [
"7592379",
"11386347"
] | [
"Glucose kinase-dependent catabolite repression in Staphylococcus xylosus.",
"Glucose kinase of Streptomyces coelicolor A3(2): large-scale purification and biochemical analysis."
] | [
1995,
2000
] | 2 | [
"IPR000600"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
7808,
3,
104
] | 3 | [] | [] | 0 | true | Family | Glucokinase ROK | Glucokinase ROK | ROK_glcA | 1 |
IPR004655 | 4,655 | Beta-ketoacyl-[acyl-carrier-protein] synthase III | FabH | Family | 28,820 | false | false | Beta-ketoacyl-[acyl-carrier-protein] synthase III (FabH) generally initiates elongation in type II fatty acid synthase systems found in bacteria and plants. It is responsible for producing the multitude of fatty acid structures found in bacterial membranes [ ]. The two members of this subfamily from Bacillus subtilis d... | [
"GO:0004315",
"GO:0006633"
] | [
"3-oxoacyl-[acyl-carrier-protein] synthase activity",
"fatty acid biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_01815",
"TIGR00747"
] | [
"FabH",
"fabH"
] | [
27303,
28460
] | 2 | [
"EC",
"EC",
"GP",
"GP",
"GP",
"GP",
"METACYC"
] | [
"2.3.1",
"2.3.1.180",
"GenProp0681",
"GenProp1220",
"GenProp1415",
"GenProp1512",
"PWY-4381"
] | [
"EC:2.3.1",
"EC:2.3.1.180",
"GP:GenProp0681",
"GP:GenProp1220",
"GP:GenProp1415",
"GP:GenProp1512",
"METACYC:PWY-4381"
] | 7 | [
"1ebl",
"1hn9",
"1hnd",
"1hnh",
"1hnj",
"1hnk",
"1hzp",
"1m1m",
"1mzj",
"1mzs",
"1u6e",
"1u6s",
"1ub7",
"1zow",
"2ahb",
"2aj9",
"2ebd",
"2eft",
"2gyo",
"2qnx",
"2qny",
"2qnz",
"2qo0",
"2qo1",
"2qx1",
"2x3e",
"3il3",
"3il4",
"3il5",
"3il6",
"3il7",
"3il9"... | 60 | [
"PUB00007690"
] | [
"10629181"
] | [
"beta-ketoacyl-acyl carrier protein synthase III (FabH) is a determining factor in branched-chain fatty acid biosynthesis."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified bacterial viruses",
"unclassified sequences"
] | [
12,
27217,
1167,
2,
422
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
4,
1,
4,
8
] | 4 | true | Family | Beta-ketoacyl-[acyl-carrier-protein] synthase III | Beta-ketoacyl-[acyl-carrier-protein] synthase III | FabH | 1 |
IPR004656 | 4,656 | Hydroxymethylglutaryl-CoA synthase | HMG_CoA_Synthase | Family | 656 | false | false | This entry represents Hydroxymethylglutaryl-CoA synthase and related prokaryotic proteins. These proteins show considerable similarity and identical active site residues to FabH, the beta-ketoacyl-acyl carrier protein synthase III of bacteria and plants. They catalyze the condensation of acetyl-CoA with acetoacetyl-CoA... | [
"GO:0004421"
] | [
"hydroxymethylglutaryl-CoA synthase activity"
] | [
"molecular_function"
] | 1 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_01409",
"TIGR00748"
] | [
"HMG_CoA_synth_arch",
"HMG_CoA_syn_Arc"
] | [
535,
656
] | 2 | [
"EC",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.3.3.10",
"GenProp0047",
"PWY-6174",
"PWY-7391",
"PWY-7524",
"PWY-7571",
"PWY-8125",
"PWY-922"
] | [
"EC:2.3.3.10",
"GP:GenProp0047",
"METACYC:PWY-6174",
"METACYC:PWY-7391",
"METACYC:PWY-7524",
"METACYC:PWY-7571",
"METACYC:PWY-8125",
"METACYC:PWY-922"
] | 8 | [
"6esq",
"6et9"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"unclassified sequences"
] | [
479,
161,
16
] | 3 | [] | [] | 0 | true | Family | Hydroxymethylglutaryl-CoA synthase | Hydroxymethylglutaryl-CoA synthase | HMG_CoA_Synthase | 9 |
IPR004657 | 4,657 | 1,4-dihydroxy-2-naphthoate octaprenyltransferase | MenA | Family | 10,270 | false | false | This membrane-associated enzyme converts 1,4-dihydroxy-2-naphthoic acid (DHNA) to demethylmenaquinone (DMK), a step in menaquinone biosynthesis. A key reaction in the biosynthesis of menaquinone involves the conversion of the soluble bicyclic naphthalenoid compound 1, 4-dihydroxy-2-naphthoic acid (DHNA) to the membrane... | [
"GO:0046428",
"GO:0009234",
"GO:0016020"
] | [
"1,4-dihydroxy-2-naphthoate polyprenyltransferase activity",
"menaquinone biosynthetic process",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"HAMAP"
] | [
"MF_01937"
] | [
"MenA_1"
] | [
10270
] | 1 | [
"EC",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.5.1.74",
"GenProp0058",
"PWY-5839",
"PWY-5851",
"PWY-5852",
"PWY-5853",
"PWY-5890",
"PWY-5891",
"PWY-5892",
"PWY-5895",
"PWY-7997"
] | [
"EC:2.5.1.74",
"GP:GenProp0058",
"METACYC:PWY-5839",
"METACYC:PWY-5851",
"METACYC:PWY-5852",
"METACYC:PWY-5853",
"METACYC:PWY-5890",
"METACYC:PWY-5891",
"METACYC:PWY-5892",
"METACYC:PWY-5895",
"METACYC:PWY-7997"
] | 11 | [] | 0 | [
"PUB00007691"
] | [
"9573170"
] | [
"Menaquinone (vitamin K2) biosynthesis: localization and characterization of the menA gene from Escherichia coli."
] | [
1998
] | 1 | [
"IPR026046"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctJ0s2",
"metagenomes"
] | [
342,
9644,
34,
1,
249
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | 1,4-dihydroxy-2-naphthoate octaprenyltransferase | 1,4-dihydroxy-2-naphthoate octaprenyltransferase | MenA | 5 |
IPR004658 | 4,658 | Outer membrane lipoprotein Slp | OMP_Slp | Family | 3,222 | false | false | Slp superfamily members are present in the Gram-negative gammaproteobacteria Escherichia coli (which also contains a close paralog), Haemophilus influenzae and Pasteurella multocida and Vibrio cholerae. The known members of the family to date share a motif LX[GA]C near the N terminus, which is compatible with the possi... | [
"GO:0019867"
] | [
"outer membrane"
] | [
"cellular_component"
] | 1 | [
"PFAM",
"PIRSF",
"PANTHER",
"NCBIFAM"
] | [
"PF03843",
"PIRSF004982",
"PTHR37530",
"TIGR00752"
] | [
"Slp",
"SlP",
"",
"slp"
] | [
3220,
2831,
3177,
2350
] | 4 | [] | [] | [] | 0 | [] | 0 | [
"PUB00017586"
] | [
"8022277"
] | [
"Characterization of the carbon starvation-inducible and stationary phase-inducible gene slp encoding an outer membrane lipoprotein in Escherichia coli."
] | [
1994
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"unclassified sequences"
] | [
3180,
3,
39
] | 3 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Outer membrane lipoprotein Slp | Outer membrane lipoprotein Slp | OMP_Slp | 1 |
IPR004659 | 4,659 | Ribonuclease E/G | RNase_E/G | Family | 30,749 | false | false | Ribonuclease E and ribonuclease G are related enzymes that cleave a wide variety of RNAs [ , ]. In Escherichia coli, both enzymes have been shown to play a role in the maturation of the 5' end of 16S RNA [ ]. RNase E is a major subunit the eubacterial degradosome - a large, multiprotein, multienzyme complex involved in... | [
"GO:0003723",
"GO:0004540",
"GO:0006396"
] | [
"RNA binding",
"RNA nuclease activity",
"RNA processing"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PANTHER",
"NCBIFAM"
] | [
"PTHR30001",
"TIGR00757"
] | [
"",
"RNaseEG"
] | [
30746,
27666
] | 2 | [
"EC",
"GP"
] | [
"3.1.26",
"GenProp1360"
] | [
"EC:3.1.26",
"GP:GenProp1360"
] | 2 | [
"1slj",
"1smx",
"1sn8",
"2bx2",
"2c0b",
"2c4r",
"2vmk",
"2vrt",
"4oxp",
"5f6c",
"6g63",
"6x2d",
"8b0j"
] | 13 | [
"PUB00033641",
"PUB00033948",
"PUB00056899",
"PUB00097829",
"PUB00097830"
] | [
"16237448",
"16766188",
"10362534",
"26694614",
"27288443"
] | [
"Structure of Escherichia coli RNase E catalytic domain and implications for RNA turnover.",
"The RNA degradosome: life in the fast lane of adaptive molecular evolution.",
"Escherichia coli cafA gene encodes a novel RNase, designated as RNase G, involved in processing of the 5' end of 16S rRNA.",
"Distinct Re... | [
2005,
2006,
1999,
2016,
2016
] | 5 | [] | [
"IPR028878"
] | 0 | 1 | 0 | [
"Bacteria",
"Candidatus Methanofastidiosum methylothiophilum",
"Eukaryota",
"unclassified sequences"
] | [
28963,
1,
1104,
681
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
5,
2,
5,
9
] | 4 | true | Family | Ribonuclease E/G | Ribonuclease E/G | RNase_E/G | 3 |
IPR004660 | 4,660 | Pyruvate dehydrogenase E1 component | PDH_E1 | Family | 16,128 | false | false | Most members of this family are pyruvate dehydrogenase complex, E1 component. It includes a counterexample from Pseudomonas putida, MdeB, that is active as an E1 component of an alpha-ketoglutarate dehydrogenase complex rather than a pyruvate dehydrogenase complex. The second pyruvate dehydrogenase complex E1 protein f... | [
"GO:0016491"
] | [
"oxidoreductase activity"
] | [
"molecular_function"
] | 1 | [
"PIRSF",
"NCBIFAM"
] | [
"PIRSF000156",
"TIGR00759"
] | [
"Pyruvate_dh_E1",
"aceE"
] | [
15970,
14089
] | 2 | [
"EC",
"GP",
"GP"
] | [
"1.2.4.1",
"GenProp1536",
"GenProp1710"
] | [
"EC:1.2.4.1",
"GP:GenProp1536",
"GP:GenProp1710"
] | 3 | [
"1l8a",
"1rp7",
"2g25",
"2g28",
"2g67",
"2iea",
"2qta",
"2qtc",
"3lpl",
"3lq2",
"3lq4",
"4qoy"
] | 12 | [] | [] | [] | [] | 0 | [] | [
"IPR017600"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
18,
15784,
28,
298
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Pyruvate dehydrogenase E1 component | Pyruvate dehydrogenase E1 component | PDH_E1 | 3 |
IPR004662 | 4,662 | Acetylglutamate kinase family | AcgluKinase_fam | Family | 25,888 | false | false | N -Acetylglutamate (NAG) fulfils distinct biological roles in lower and higher organisms. In prokaryotes, lower eukaryotes and plants it is the first intermediate in the biosynthesis of arginine, whereas in ureotelic (excreting nitrogen mostly in the form of urea) vertebrates, it is an essential allosteric cofactor for... | [
"GO:0005737"
] | [
"cytoplasm"
] | [
"cellular_component"
] | 1 | [
"PIRSF",
"NCBIFAM"
] | [
"PIRSF000728",
"TIGR00761"
] | [
"NAGK",
"argB"
] | [
22788,
25531
] | 2 | [
"EC",
"EC",
"GP",
"GP",
"GP",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.2",
"2.7.2.8",
"GenProp0118",
"GenProp0193",
"GenProp1466",
"PWY-5154",
"R-DDI-70635",
"R-SCE-70635",
"R-SPO-70635"
] | [
"EC:2.7.2",
"EC:2.7.2.8",
"GP:GenProp0118",
"GP:GenProp0193",
"GP:GenProp1466",
"METACYC:PWY-5154",
"REACTOME:R-DDI-70635",
"REACTOME:R-SCE-70635",
"REACTOME:R-SPO-70635"
] | 9 | [
"1gs5",
"1gsj",
"1oh9",
"1oha",
"1ohb",
"2ap9",
"2bty",
"2buf",
"2jj4",
"2rd5",
"2v5h",
"2wxb",
"2x2w",
"3l86",
"3s6g",
"3s6h",
"3s6k",
"3s7y",
"3t7b",
"3u6u",
"3wwm",
"3wwn",
"3zzf",
"3zzg",
"3zzh",
"3zzi",
"4ab7",
"4kzt",
"4usj",
"7nlf",
"7nln",
"7nlo"... | 46 | [
"PUB00014499",
"PUB00083921",
"PUB00087123"
] | [
"12633501",
"23434852",
"25392000"
] | [
"N-acetylglutamate and its changing role through evolution.",
"Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus.",
"Structural insight into amino group-carrier protein-mediated lysine biosynthesis: crystal structure of the LysZ·LysW complex from Thermus thermophilus."
] | [
2003,
2013,
2015
] | 3 | [] | [
"IPR037528",
"IPR037529"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
789,
21734,
2885,
1,
479
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
4,
1,
1,
6,
1,
1,
6
] | 7 | true | Family | Acetylglutamate kinase family | Acetylglutamate kinase family | AcgluKinase_fam | 8 |
IPR004663 | 4,663 | Lon protease, archaeal | Lon_arc | Family | 734 | false | false | This entry defines the archaeal lon protease homologues, which are ATP-dependent serine peptidases belonging to peptidase family S16 (lon protease family). A lon protease from Thermococcus kodakaraensis has been characterised and displays ATP-independent proteolytic activity towards unfolded proteins and ATP-dependent ... | [
"GO:0004176",
"GO:0005524",
"GO:0030163"
] | [
"ATP-dependent peptidase activity",
"ATP binding",
"protein catabolic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00764"
] | [
"lon_rel"
] | [
734
] | 1 | [
"EC",
"METACYC"
] | [
"3.4.21.-",
"PWY-7884"
] | [
"EC:3.4.21.-",
"METACYC:PWY-7884"
] | 2 | [
"3k1j",
"4zpx"
] | 2 | [
"PUB00062806"
] | [
"12057965"
] | [
"A membrane-bound archaeal Lon protease displays ATP-independent proteolytic activity towards unfolded proteins and ATP-dependent activity for folded proteins."
] | [
2002
] | 1 | [
"IPR027065"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Paenibacillaceae",
"ecological metagenomes"
] | [
714,
3,
17
] | 3 | [] | [] | 0 | true | Family | Lon protease, archaeal | Lon protease, archaeal | Lon_arc | 8 |
IPR004665 | 4,665 | Transcription termination factor Rho | Term_rho | Family | 24,169 | false | false | Rho-dependent transcription terminators participate in sophisticated genetic regulatory mechanisms, in both bacteria and phages; they occur in regulatory regions preceding the coding sequences of genes and within coding sequences, as well as at the end of transcriptional units, to prevent read through transcription. Rh... | [
"GO:0003723",
"GO:0005524",
"GO:0008186",
"GO:0006353"
] | [
"RNA binding",
"ATP binding",
"ATP-dependent activity, acting on RNA",
"DNA-templated transcription termination"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process"
] | 4 | [
"HAMAP",
"PANTHER",
"NCBIFAM"
] | [
"MF_01884",
"PTHR46425",
"TIGR00767"
] | [
"Rho",
"",
"rho"
] | [
23616,
24168,
21848
] | 3 | [
"EC",
"GP",
"METACYC"
] | [
"3.6.4.-",
"GenProp0812",
"PWY-7250"
] | [
"EC:3.6.4.-",
"GP:GenProp0812",
"METACYC:PWY-7250"
] | 3 | [
"1a62",
"1a63",
"1a8v",
"1pv4",
"1pvo",
"1xpo",
"1xpr",
"1xpu",
"2a8v",
"2ht1",
"3ice",
"3l0o",
"5jji",
"5jjk",
"5jjl",
"6duq",
"6wa8",
"6xas",
"6xav",
"6z9p",
"6z9q",
"6z9r",
"6z9s",
"6z9t",
"7adb",
"7adc",
"7add",
"7ade",
"7oqh",
"7x2r",
"8e3h",
"8e5l"... | 56 | [
"PUB00045823"
] | [
"16946247"
] | [
"Rho-dependent terminators and transcription termination."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
23355,
128,
686
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Transcription termination factor Rho | Transcription termination factor Rho | Term_rho | 3 |
IPR004667 | 4,667 | ADP/ATP carrier protein, bacterial type | ADP_ATP_car_bac_type | Family | 3,442 | false | false | These proteins are members of the ATP:ADP Antiporter (AAA) family, which consists of nucleotide transporters that have 12 GES predicted transmembrane regions. One protein from Rickettsia prowazekii functions to take up ATP from the eukaryotic cell cytoplasm into the bacterium in exchange for ADP. Five AAA family paralo... | [
"GO:0005471",
"GO:0006862",
"GO:0016020"
] | [
"ATP:ADP antiporter activity",
"nucleotide transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PANTHER",
"NCBIFAM"
] | [
"PF03219",
"PTHR31187",
"TIGR00769"
] | [
"TLC",
"",
"AAA"
] | [
3348,
2652,
1673
] | 3 | [] | [] | [] | 0 | [
"9j3j",
"9j3l",
"9j3m",
"9j3n",
"9j3o"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
984,
2418,
40
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
19,
13,
25
] | 3 | true | Family | ADP/ATP carrier protein, bacterial type | ADP/ATP carrier protein, bacterial type | ADP_ATP_car_bac_type | 4 |
IPR004668 | 4,668 | Anaerobic c4-dicarboxylate membrane transporter | Anaer_Dcu_memb_transpt | Family | 6,733 | false | false | These proteins are members of the C4-Dicarboxylate Uptake (Dcu) family. Most proteins in this family are predicted to have 12 GES predicted transmembrane regions; however the one member whose membrane topology has been experimentally determined has 10 transmembrane regions, with both the N- and C-termini localized to t... | [
"GO:0015556",
"GO:0015740",
"GO:0016020"
] | [
"C4-dicarboxylate transmembrane transporter activity",
"C4-dicarboxylate transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PIRSF",
"PANTHER",
"NCBIFAM"
] | [
"PF03605",
"PIRSF004539",
"PTHR36106",
"TIGR00770"
] | [
"DcuA_DcuB",
"C4-dicrbxl_trns",
"",
"Dcu"
] | [
6688,
5972,
6713,
6059
] | 4 | [] | [] | [] | 0 | [] | 0 | [
"PUB00033874",
"PUB00033875",
"PUB00033876",
"PUB00033877",
"PUB00033878",
"PUB00033879"
] | [
"9733683",
"8131924",
"14654290",
"11004174",
"7961398",
"9852003"
] | [
"Topological analysis of DcuA, an anaerobic C4-dicarboxylate transporter of Escherichia coli.",
"Construction and properties of Escherichia coli mutants defective in two genes encoding homologous membrane proteins with putative roles in anaerobic C4-dicarboxylic acid transport.",
"Genes responsible for anaerobi... | [
1998,
1993,
2003,
2000,
1994,
1998
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
6706,
5,
22
] | 3 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Anaerobic c4-dicarboxylate membrane transporter | Anaerobic c4-dicarboxylate membrane transporter | Anaer_Dcu_memb_transpt | 9 |
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