LiteFold/InterPro · Datasets at Hugging Face

IPR004917

4,917

Aphid transmission protein

Caulimo_AT

Family

128

false

This protein is found in various caulimoviruses. It codes for an 18kDa protein (PII), which is dispensable for infection but which is required for aphid transmission of the virus [ ]. This protein interacts with the PIII protein [ ].

[]

0

[ "PFAM" ]

[ "PF03233" ]

[ "Cauli_AT" ]

[ 128 ]

1

[]

0

[]

0

[ "PUB00007216", "PUB00007217" ]

[ "6311674", "10601029" ]

[ "Aphid transmission and a polypeptide are specified by a defined region of the cauliflower mosaic virus genome.", "Aphid transmission of cauliflower mosaic virus requires the viral PIII protein." ]

[ 1983, 1999 ]

2

[]

0

null

[ "Caulimovirus", "Pentapetalae" ]

[ 88, 40 ]

2

[]

0

true

Family

Aphid transmission protein

Caulimo_AT

1

IPR004918

4,918

Cdc37

Family

5,037

false

In the budding yeast Saccharomyces cerevisiae (Baker's yeast), cell division control protein Cdc37 is required for the productive formation of Cdc28-cyclin complexes. Cdc37 may be a kinase targeting subunit of Hsp90 [ ].

[]

0

[ "PANTHER" ]

[ "PTHR12800" ]

[ "" ]

[ 5037 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-114608", "R-BTA-1227986", "R-BTA-5675482", "R-BTA-8863795", "R-BTA-9013418", "R-BTA-9652282", "R-CEL-114608", "R-CEL-1227986", "R-CEL-8863795", "R-CEL-9652282", "R-DME-114608", "R-DME-1227986", "R-DME-8863795", "R-DME-9013418", "R-DME-9652282", "R-DRE-114608", "R-HSA-114608", ...

[ "REACTOME:R-BTA-114608", "REACTOME:R-BTA-1227986", "REACTOME:R-BTA-5675482", "REACTOME:R-BTA-8863795", "REACTOME:R-BTA-9013418", "REACTOME:R-BTA-9652282", "REACTOME:R-CEL-114608", "REACTOME:R-CEL-1227986", "REACTOME:R-CEL-8863795", "REACTOME:R-CEL-9652282", "REACTOME:R-DME-114608", "REACTOME:R...

52

[ "1us7", "2k5b", "2n5x", "2nca", "2w0g", "5fwk", "5fwl", "5fwm", "5fwp", "7z37", "7z38", "7zr0", "7zr5", "7zr6", "8fx4", "8gae", "8gft", "8u1l", "9kqn" ]

19

[ "PUB00007218" ]

[ "9242486" ]

[ "Cdc37 is a molecular chaperone with specific functions in signal transduction." ]

[ 1997 ]

1

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 5036, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 3, 3, 3, 10, 5, 1, 19, 1, 1 ]

9

true

Family

Cdc37

6

IPR004919

4,919

GmrSD restriction endonucleases, N-terminal domain

GmrSD_N

Domain

21,860

false

This entry (previously known as DUF262) represents a domain found N-terminal in the GmrSD family of modification-dependent restriction endonucleases including BrxU and SspE proteins [ , ]. BrxU is a type IV DNA modification-dependent restriction enzyme, which is promiscuous and uses a range of nucleotide and metal co-f...

[]

0

[ "PFAM" ]

[ "PF03235" ]

[ "GmrSD_N" ]

[ 21860 ]

1

[]

0

[ "6jiv", "7drr", "7drs", "7p9k", "7p9m", "9jfl" ]

6

[ "PUB00155271", "PUB00155272" ]

[ "34657954", "36351933" ]

[ "The phage defence island of a multidrug resistant plasmid uses both BREX and type IV restriction for complementary protection from viruses.", "Nicking mechanism underlying the DNA phosphorothioate-sensing antiphage defense by SspE." ]

[ 2021, 2022 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 415, 19769, 1239, 116, 321 ]

5

[]

0

true

Domain

GmrSD restriction endonucleases, N-terminal domain

GmrSD_N

5

IPR004922

4,922

ESAG protein

ESAG

Family

70

false

Trypanosoma brucei is the causative agent of sleeping sickness in humans and nagana in cattle. The parasite lives extracellularly in the blood and tissue fluids of the mammalian host, and is transmitted by the bite of infected tsetse. Each variant surface glycoprotein (Vsg) expression site (ES) in bloodstream-form T. b...

[]

0

[ "PFAM" ]

[ "PF03238" ]

[ "ESAG1" ]

[ 70 ]

1

[]

0

[]

0

[ "PUB00014951" ]

[ "8892306" ]

[ "Targeted disruption of expression site-associated gene-1 in bloodstream-form Trypanosoma brucei." ]

[ 1996 ]

1

[]

0

null

[ "Trypanozoon" ]

[ 70 ]

1

[]

0

true

Family

ESAG protein

ESAG

1

IPR004923

4,923

Iron permease FTR1/Fip1/EfeU

FTR1/Fip1/EfeU

Family

14,145

false

Fungi uptake extracellular ferrous iron (Fe2+) using a bipartite high-affinity transporter consisting of a multicopper ferroxidase associated with a membrane permease which translocates generated ferric iron (Fe3+) into the cytosol. The Saccharomyces cerevisiae (Baker's yeast) iron permease FTR1 is a plasma membrane pe...

[ "GO:0005381", "GO:0034755", "GO:0016020", "GO:0033573" ]

[ "iron ion transmembrane transporter activity", "iron ion transmembrane transport", "membrane", "high-affinity iron permease complex" ]

[ "molecular_function", "biological_process", "cellular_component", "cellular_component" ]

4

[ "PFAM", "PANTHER" ]

[ "PF03239", "PTHR31632" ]

[ "FTR1", "" ]

[ 14089, 14059 ]

2

[ "REACTOME" ]

[ "R-HSA-9638482" ]

[ "REACTOME:R-HSA-9638482" ]

1

[]

0

[ "PUB00015322", "PUB00067523", "PUB00070773", "PUB00070775", "PUB00070776", "PUB00070777", "PUB00089625" ]

[ "8599111", "17627767", "8995275", "23764491", "16987175", "10608875", "15504822" ]

[ "A permease-oxidase complex involved in high-affinity iron uptake in yeast.", "EfeUOB (YcdNOB) is a tripartite, acid-induced and CpxAR-regulated, low-pH Fe2+ transporter that is cryptic in Escherichia coli K-12 but functional in E. coli O157:H7.", "An oxidase-permease-based iron transport system in Schizosaccha...

[ 1996, 2007, 1997, 2013, 2006, 1999, 2004 ]

7

[]

[ "IPR005217" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 91, 10731, 3057, 266 ]

4

[ "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 2, 1 ]

4

true

Family

Iron permease FTR1/Fip1/EfeU

FTR1/Fip1/EfeU

4

IPR004926

4,926

Late embryogenesis abundant protein, LEA_3a subgroup

LEA_3a

Family

2,191

false

This entry represents Lea5(D73) by LEA-3. Proteins in this entry includes LEA5 from Citrus sinensis [ ], whose expression is induced by salt, drought and heat stress [ ]. This entry also includes At4g02380 (SAG21), At1g02820 (LEA2), At3g53770 (LEA37) and At4g15910 (LEA41) from Arabidopsis [ ]. LEA (late embryogenesis a...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF03242", "PTHR33509" ]

[ "LEA_3a", "" ]

[ 2191, 1973 ]

2

[]

0

[]

0

[ "PUB00009713", "PUB00055583", "PUB00055584", "PUB00088595", "PUB00088596", "PUB00088597" ]

[ "10681550", "8278514", "7894024", "18318901", "21034219", "25005920" ]

[ "Highly hydrophilic proteins in prokaryotes and eukaryotes are common during conditions of water deficit.", "Cotton Lea5 and Lea14 encode atypical late embryogenesis-abundant proteins.", "Drought, heat and salt stress induce the expression of a citrus homologue of an atypical late-embryogenesis Lea5 gene.", "...

[ 2000, 1993, 1995, 2008, 2011, 2014 ]

6

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 5, 2186 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 16, 19, 18 ]

3

true

Family

Late embryogenesis abundant protein, LEA_3a subgroup

LEA_3a

3

IPR004927

4,927

Alkylmercury lyase

MerB

Family

1,724

false

Mercury is a highly toxic metal. Toxicity can result from three different mercurial forms: elemental, inorganic ion and organomercurial compounds. The ability of bacteria to detoxify mercurial compounds by reduction and volatilisation is conferred by the Mer genes, which are usually plasmid encoded (although chromosome...

[ "GO:0018836" ]

[ "alkylmercury lyase activity" ]

[ "molecular_function" ]

1

[ "HAMAP", "PFAM", "PIRSF", "PRINTS" ]

[ "MF_00714", "PF03243", "PIRSF001458", "PR01699" ]

[ "MerB", "MerB", "MerB", "ORGNOHGLYASE" ]

[ 142, 1720, 453, 620 ]

4

[ "EC", "GP" ]

[ "4.99.1.2", "GenProp0151" ]

[ "EC:4.99.1.2", "GP:GenProp0151" ]

2

[ "1s6l", "3f0o", "3f0p", "3f2f", "3f2g", "3f2h", "3fn8", "5c0t", "5c0u", "5c17", "5dsf", "5u79", "5u7a", "5u7b", "5u7c", "5u82", "5u83", "5u88" ]

18

[ "PUB00010313", "PUB00010357" ]

[ "9168120", "10548738" ]

[ "Nucleotide sequence and expression of the organomercurial-resistance determinants from a Pseudomonas K-62 plasmid pMR26.", "Identification of three merB genes and characterization of a broad-spectrum mercury resistance module encoded by a class II transposon of Bacillus megaterium strain MB1." ]

[ 1997, 1999 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 67, 1423, 206, 28 ]

4

[]

0

true

Family

Alkylmercury lyase

MerB

2

IPR004928

4,928

Photosystem I PsaH, reaction centre subunit VI

PSI_PsaH

Family

878

false

Photosystem I, a membrane complex found in the chloroplasts of plants and cyanobacteria uses light energy to transfer electrons from plastocyanin to ferredoxin. The electron transfer components of the photosystem include the primary electron donor chlorophyll P-700 and 5 electron acceptors: chlorophyll (A0), phylloquin...

[ "GO:0015979", "GO:0009522", "GO:0009538" ]

[ "photosynthesis", "photosystem I", "photosystem I reaction center" ]

[ "biological_process", "cellular_component", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF03244", "PTHR34787" ]

[ "PSI_PsaH", "" ]

[ 878, 851 ]

2

[ "GP" ]

[ "GenProp0660" ]

[ "GP:GenProp0660" ]

1

[ "2o01", "2wsc", "2wse", "2wsf", "3lw5", "4rku", "4xk8", "4y28", "5l8r", "5zji", "6igz", "6ijo", "6l35", "6sl5", "6yac", "6yez", "6zoo", "6zxs", "6zzx", "6zzy", "7d0j", "7dkz", "7dz7", "7dz8", "7ew6", "7ewk", "7f9o", "7ksq", "7kux", "7wfd", "7wfe", "7wg5"...

49

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 4, 874 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 6, 1, 5 ]

3

true

Family

Photosystem I PsaH, reaction centre subunit VI

PSI_PsaH

9

IPR004929

4,929

Spanin, inner membrane subunit

I-spanin

Family

4,915

false

The lysis of Gram-negative hosts by double-strand DNA bacteriophages requires, in addition to the actions of a holin and endolysin, a third step involving the spanin complex. This complex consists of a small outer membrane lipoprotein and an integral cytoplasmic membrane protein, designated as o-spanins and i-spanins, ...

[ "GO:0044659" ]

[ "viral release from host cell by cytolysis" ]

[ "biological_process" ]

1

[ "HAMAP", "PFAM" ]

[ "MF_04137", "PF03245" ]

[ "I_SPANIN_LAMBDA", "Phage_lysis" ]

[ 2606, 4915 ]

2

[]

0

[]

0

[ "PUB00034469", "PUB00077481", "PUB00082268", "PUB00082269" ]

[ "10628848", "23387988", "24585055", "22904283" ]

[ "Complementation and characterization of the nested Rz and Rz1 reading frames in the genome of bacteriophage lambda.", "Spanin function requires subunit homodimerization through intermolecular disulfide bonds.", "Phage lysis: three steps, three choices, one outcome.", "The spanin complex is essential for lamb...

[ 1999, 2013, 2014, 2012 ]

4

[]

[ "IPR016417" ]

0

1

0

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 4456, 28, 425, 6 ]

4

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Spanin, inner membrane subunit

I-spanin

5

IPR004930

4,930

Pneumovirus nucleocapsid protein

Pneumo_ncap

Family

2,606

false

This family is the Pneumovirus nucleocapsid protein. It is the most abundant protein in the virion and an important element in conferring helical symmetry on the nucleoprotein core as well as interacting with the M protein during virion formation.

[ "GO:0003723", "GO:0019013" ]

[ "RNA binding", "viral nucleocapsid" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF03246" ]

[ "Pneumo_ncap" ]

[ 2606 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-9820960", "R-HSA-9820962", "R-HSA-9828642", "R-HSA-9828721", "R-HSA-9828806", "R-HSA-9833109", "R-HSA-9833110", "R-HSA-9833482", "R-HSA-9834752" ]

[ "REACTOME:R-HSA-9820960", "REACTOME:R-HSA-9820962", "REACTOME:R-HSA-9828642", "REACTOME:R-HSA-9828721", "REACTOME:R-HSA-9828806", "REACTOME:R-HSA-9833109", "REACTOME:R-HSA-9833110", "REACTOME:R-HSA-9833482", "REACTOME:R-HSA-9834752" ]

9

[ "2wj8", "2yhm", "4bkk", "4uc6", "4uc7", "4uc8", "4uc9", "4uca", "4ucb", "4ucc", "4ucd", "4uce", "4v5v", "5fvc", "5fvd", "6yjl", "8iuo", "8oou", "8op1", "8op2", "8pdl", "8pdm", "8pdn", "8pdo", "8pdp", "8pdq", "8pdr", "8pds" ]

28

[]

0

[]

0

null

[ "Pneumoviridae" ]

[ 2606 ]

1

[]

0

true

Family

Pneumovirus nucleocapsid protein

Pneumo_ncap

6

IPR004932

4,932

Retrieval of early ER protein Rer1

Rer1

Family

7,276

false

RER1 family proteins are involved in the retrieval of some endoplasmic reticulum membrane proteins from the early golgi compartment. The C terminus of yeast Rer1p interacts with a coatomer complex [ ].

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF03248", "PIRSF016013", "PTHR10743" ]

[ "Rer1", "AtER_Rer1p", "" ]

[ 7276, 5058, 7163 ]

3

[]

0

[]

0

[ "PUB00007222" ]

[ "11238450" ]

[ "Rer1p, a retrieval receptor for endoplasmic reticulum membrane proteins, is dynamically localized to the Golgi apparatus by coatomer." ]

[ 2001 ]

1

[]

0

null

[ "Eukaryota" ]

[ 7276 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 16, 1, 4, 2, 8, 1, 1, 11, 4, 1, 1, 14 ]

12

true

Family

Retrieval of early ER protein Rer1

Rer1

1

IPR004934

4,934

Tropomodulin

TMOD

Family

9,085

false

Actin filaments have an intrinsic polarity, each with a fast-growing (barbed) end and a slow-growing (pointed) end. The slow-growing end is regulated by tropomodulins, a family of capping proteins that require tropomyosins for optimal function [ ]. Tropomyosins contains two domains: an N-terminal unstructured tropomyos...

[ "GO:0005523", "GO:0051694" ]

[ "tropomyosin binding", "pointed-end actin filament capping" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER" ]

[ "PF03250", "PTHR10901" ]

[ "Tropomodulin", "" ]

[ 7808, 9005 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-390522", "R-CEL-445355", "R-HSA-390522", "R-HSA-445355", "R-HSA-9013418", "R-HSA-9696264", "R-MMU-390522", "R-MMU-445355", "R-MMU-9013418", "R-MMU-9696264", "R-RNO-390522", "R-RNO-445355" ]

[ "REACTOME:R-BTA-390522", "REACTOME:R-CEL-445355", "REACTOME:R-HSA-390522", "REACTOME:R-HSA-445355", "REACTOME:R-HSA-9013418", "REACTOME:R-HSA-9696264", "REACTOME:R-MMU-390522", "REACTOME:R-MMU-445355", "REACTOME:R-MMU-9013418", "REACTOME:R-MMU-9696264", "REACTOME:R-RNO-390522", "REACTOME:R-RNO...

12

[ "1io0", "1pgv", "4pkg", "4pkh", "4pki", "4rwt", "4z79", "4z8g", "4z94", "5wfn", "6ut2", "8f8t", "8iah", "8iai" ]

14

[ "PUB00071747", "PUB00071750" ]

[ "19216712", "25061212" ]

[ "Capping complex formation at the slow-growing end of the actin filament.", "Actin cytoskeleton. Mechanism of actin filament pointed-end capping by tropomodulin." ]

[ 2008, 2014 ]

2

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 2, 9083 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 18, 16, 29, 19, 29 ]

6

true

Family

Tropomodulin

TMOD

5

IPR004935

4,935

Tymovirus 45/70kDa protein

45/70kDa_tymovirus

Family

61

false

Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overalps a larger ORF that is thought to be the ...

[]

0

[ "PFAM" ]

[ "PF03251" ]

[ "Tymo_45kd_70kd" ]

[ 61 ]

1

[]

0

[]

0

[ "PUB00007227" ]

[ "2800337" ]

[ "Nucleotide sequence of the ononis yellow mosaic tymovirus genome." ]

[ 1989 ]

1

[]

0

null

[ "Tymovirales" ]

[ 61 ]

1

[]

0

true

Family

Tymovirus 45/70kDa protein

45/70kDa_tymovirus

9

IPR004936

4,936

Herpesvirus UL21

Herpes_UL21

Family

420

false

The UL21 protein appears to be a dispensable component in herpesviruses [ ].

[]

0

[ "PFAM" ]

[ "PF03252" ]

[ "Herpes_UL21" ]

[ 420 ]

1

[]

0

[ "4u4h", "5ed7" ]

2

[ "PUB00007228" ]

[ "8151763" ]

[ "The UL21 gene products of herpes simplex virus 1 are dispensable for growth in cultured cells." ]

[ 1994 ]

1

[]

0

null

[ "Alphaherpesvirinae" ]

[ 420 ]

1

[]

0

true

Family

Herpesvirus UL21

Herpes_UL21

5

IPR004937

4,937

Urea transporter

Urea_transporter

Family

5,277

false

Proteins in this entry include low-affinity urea transporters found in the erythrocytes and kidneys of higher organisms. The erythrocyte proteins carry the clinically important Kidd (Jk) blood group antigens which help determine blood type. The two commonest forms are Jk(a) and Jk(b), which arise from a single residue ...

[ "GO:0015204", "GO:0071918", "GO:0016020" ]

[ "urea transmembrane transporter activity", "urea transmembrane transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF03253", "PIRSF016502", "PTHR10464" ]

[ "UT", "Urea_transporter", "" ]

[ 5259, 2308, 5138 ]

3

[ "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "GenProp0814", "R-BTA-425366", "R-HSA-425366", "R-MMU-425366", "R-RNO-425366" ]

[ "GP:GenProp0814", "REACTOME:R-BTA-425366", "REACTOME:R-HSA-425366", "REACTOME:R-MMU-425366", "REACTOME:R-RNO-425366" ]

5

[ "3k3f", "3k3g", "3m6e", "3me1", "4ezc", "4ezd", "6qd5", "8blo", "8blp", "8xd7", "8xd9", "8xda", "8xdb", "8xdc", "8xdd", "8xde", "8xdf", "8xdg", "8xdh", "8xdi", "9j22", "9lht" ]

22

[ "PUB00033929", "PUB00033930", "PUB00033931", "PUB00033932" ]

[ "9215669", "1498276", "16479082", "12180933" ]

[ "The molecular basis of the Kidd blood group polymorphism and its lack of association with type 1 diabetes susceptibility.", "Urinary concentrating ability in patients with Jk(a-b-) blood type who lack carrier-mediated urea transport.", "A fatal case of severe hemolytic disease of newborn associated with anti-J...

[ 1997, 1992, 2006, 2002 ]

4

[]

[ "IPR017807" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 11, 2732, 2518, 16 ]

4

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 52, 7, 16 ]

4

true

Family

Urea transporter

Urea_transporter

1

IPR004938

4,938

Xyloglucan fucosyltransferase

XG_FTase

Family

4,045

false

Plant cell walls are crucial for development, signal transduction, and disease resistance in plants. Cell walls are made of cellulose, hemicelluloses, and pectins. Xyloglucan (XG), the principal load-bearing hemicellulose of dicotyledonous plants, has a terminal fucosyl residue. This fucosyltransferase adds this residu...

[ "GO:0008107", "GO:0042546", "GO:0016020" ]

[ "galactoside 2-alpha-L-fucosyltransferase activity", "cell wall biogenesis", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF03254", "PTHR31889" ]

[ "XG_FTase", "" ]

[ 3920, 3950 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.4.1.-", "PWY-1901", "PWY-1961", "PWY-1981", "PWY-2021", "PWY-2881", "PWY-2901", "PWY-2902", "PWY-4421", "PWY-4801", "PWY-5094", "PWY-5105", "PWY-5129", "PWY-5139", "PWY-5160", "PWY-5161", "PWY-5268", "PWY-5284", "PWY-5286", "PWY-5310", "PWY-5312", "PWY-5313", "PWY-5317...

[ "EC:2.4.1.-", "METACYC:PWY-1901", "METACYC:PWY-1961", "METACYC:PWY-1981", "METACYC:PWY-2021", "METACYC:PWY-2881", "METACYC:PWY-2901", "METACYC:PWY-2902", "METACYC:PWY-4421", "METACYC:PWY-4801", "METACYC:PWY-5094", "METACYC:PWY-5105", "METACYC:PWY-5129", "METACYC:PWY-5139", "METACYC:PWY-5...

200

[ "5koe", "5kop", "5kor", "5kwk", "5kx6" ]

5

[ "PUB00007229" ]

[ "10373113" ]

[ "Xyloglucan fucosyltransferase, an enzyme involved in plant cell wall biosynthesis." ]

[ 1999 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4045 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 58, 57, 151 ]

3

true

Family

Xyloglucan fucosyltransferase

XG_FTase

7

IPR004939

4,939

APC10/DOC domain

APC_su10/DOC_dom

Domain

13,158

false

The anaphase-promoting complex (APC) or cyclosome is a multi-subunit E3 protein ubiquitin ligase that regulates important events in mitosis, such as the initiation of anaphase and exit from telophase. The APC, in conjunction with other enzymes, assembles multi-ubiquitin chains on a variety of regulatory proteins, there...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF03256", "PS51284", "SM01337" ]

[ "ANAPC10", "DOC", "APC10" ]

[ 11611, 12960, 12803 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DDI-141430", "R-DDI-174048", "R-DDI-174084", "R-DDI-174154", "R-DDI-174178", "R-DDI-174184", "R-DDI-176407", "R-DDI-176408", "R-DDI-176409", "R-DDI-176412", "R-DDI-179409", "R-DDI-2467813", "R-DDI-2559582", "R-DDI-69017", "R-DDI-983168", "R-DME-141430", "R-DME-174048", "R-DME-17...

[ "REACTOME:R-DDI-141430", "REACTOME:R-DDI-174048", "REACTOME:R-DDI-174084", "REACTOME:R-DDI-174154", "REACTOME:R-DDI-174178", "REACTOME:R-DDI-174184", "REACTOME:R-DDI-176407", "REACTOME:R-DDI-176408", "REACTOME:R-DDI-176409", "REACTOME:R-DDI-176412", "REACTOME:R-DDI-179409", "REACTOME:R-DDI-246...

81

[ "1gqp", "1jhj", "3f2z", "4ui9", "5a31", "5g04", "5g05", "5khr", "5khu", "5l9t", "5l9u", "5lcw", "6q6g", "6q6h", "6tlj", "6tm5", "6tnt", "7rgw", "7z8b", "8a3t", "8a5y", "8a61", "8pkp", "8q7e", "8q7h", "8rhz", "8tar", "8tau", "9gaw", "9n9r", "9n9s" ]

31

[ "PUB00014924", "PUB00019152", "PUB00026391", "PUB00059221" ]

[ "11884135", "10318877", "11524682", "18485873" ]

[ "Implications for the ubiquitination reaction of the anaphase-promoting complex from the crystal structure of the Doc1/Apc10 subunit.", "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex.", "Crystal structure of the APC10/DOC1 subunit of the human anaphase-promotin...

[ 2002, 1999, 2001, 2008 ]

4

[]

[ "IPR037976", "IPR047052" ]

0

2

0

[ "Bacteria", "Eukaryota" ]

[ 30, 13128 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 3, 60, 4, 36, 16, 1, 5, 23, 1, 1, 11 ]

12

true

Domain

APC10/DOC domain

APC_su10/DOC_dom

3

IPR004940

4,940

Adhesin P1, C-terminal domain

Adhesin_P1_C

Domain

112

false

This entry represents a domain found towards the C-terminal of adhesins from Mycoplasmas, such as adhesin P1, first identified as the major determinant for cytoadherence and gliding motility in M. pneumoniae. P1 forms a transmembrane adhesion complex with P40/P90, called 'Nap', which mediates motility and infectivity i...

[]

0

[ "PFAM" ]

[ "PF03257" ]

[ "Adhesin_P1_C" ]

[ 112 ]

1

[]

0

[ "6rc9", "6rut", "6s3u", "6yrk", "7bwm", "8pbx", "8pby", "8pbz", "8pc0", "8pc1", "8ror" ]

11

[ "PUB00019106", "PUB00098588", "PUB00098589" ]

[ "8604303", "33057023", "32513917" ]

[ "Sequence analysis of 56 kb from the genome of the bacterium Mycoplasma pneumoniae comprising the dnaA region, the atp operon and a cluster of ribosomal protein genes.", "Immunodominant proteins P1 and P40/P90 from human pathogen Mycoplasma pneumoniae.", "Structure and mechanism of the Nap adhesion complex from...

[ 1996, 2020, 2020 ]

3

[]

0

null

[ "Mycoplasmoides" ]

[ 112 ]

1

[]

0

true

Domain

Adhesin P1, C-terminal domain

Adhesin_P1_C

7

IPR004941

4,941

FP protein, N-terminal domain

FP_N

Domain

602

false

This entry represents the N-terminal domain of the FP protein from Orgyia pseudotsugata multicapsid polyhedrosis virus, which is also found in other uncharacterised sequences from arthropods and baculovirus. The function of the FP protein is not known. The protein is missing in baculovirus FP (Few Polyhedra) mutants [ ...

[]

0

[ "PFAM" ]

[ "PF03258" ]

[ "Baculo_FP" ]

[ 602 ]

1

[]

0

[]

0

[ "PUB00007230" ]

[ "8760443" ]

[ "Characterization of the Lymantria dispar nucleopolyhedrovirus 25K FP gene." ]

[ 1996 ]

1

[]

0

null

[ "Baculoviridae", "Eumetazoa" ]

[ 140, 462 ]

2

[]

0

true

Domain

FP protein, N-terminal domain

FP_N

4

IPR004942

4,942

Roadblock/LAMTOR2 domain

Roadblock/LAMTOR2_dom

Domain

28,884

false

This domain can be found in the roadblock proteins and LAMTOR2 proteins.

[]

0

[ "PFAM", "SMART" ]

[ "PF03259", "SM00960" ]

[ "Robl_LC7", "Robl_LC7" ]

[ 28184, 27400 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1632852", "R-BTA-165159", "R-BTA-166208", "R-BTA-380972", "R-BTA-5620924", "R-BTA-5628897", "R-BTA-5674135", "R-BTA-6798695", "R-BTA-8943724", "R-BTA-9639288", "R-CEL-1632852", "R-CEL-165159", "R-CEL-166208", "R-CEL-380972", "R-CEL-5628897", "R-CEL-5674135", "R-CEL-6798695", ...

[ "REACTOME:R-BTA-1632852", "REACTOME:R-BTA-165159", "REACTOME:R-BTA-166208", "REACTOME:R-BTA-380972", "REACTOME:R-BTA-5620924", "REACTOME:R-BTA-5628897", "REACTOME:R-BTA-5674135", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-8943724", "REACTOME:R-BTA-9639288", "REACTOME:R-CEL-1632852", "REACTOME:R...

65

[ "1j3w", "1sko", "1szv", "1vet", "1veu", "1y4o", "1z09", "2b95", "2e8j", "2hz5", "2zl1", "3cpt", "3kye", "3l7h", "3l9k", "3leq", "3t12", "3t1q", "3t1r", "3t1s", "3t1x", "5x6u", "5x6v", "5y39", "5y3a", "5yk3", "6b9x", "6ehp", "6ehr", "6f1t", "6f1z", "6f38"...

81

[ "PUB00060388", "PUB00068038", "PUB00075597" ]

[ "20381137", "22980980", "25205765" ]

[ "Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.", "Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.", "Subunit composition of the human cytoplasmic dynein-2 complex." ]

[ 2010, 2012, 2014 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ssRNA phage SRR7976310_10", "unclassified sequences" ]

[ 414, 21585, 6685, 1, 199 ]

5

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 2, 11, 13, 10, 4, 1, 12 ]

7

true

Domain

Roadblock/LAMTOR2 domain

Roadblock/LAMTOR2_dom

7

IPR004943

4,943

Lepidopteran low molecular weight lipoprotein

Lipoprotein_11

Family

259

false

This family includes Lepidopteran low molecular weight (30kDa) lipoproteins (30KPs), which belong to the Lipoprotein 11 family. They are abundant proteins found in the hemolymph, mainly synthesized in the fat body and then secreted into the hemolymph during the last instar larval stage. They have very similar amino aci...

[ "GO:0005576" ]

[ "extracellular region" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF03260" ]

[ "Lipoprotein_11" ]

[ 259 ]

1

[]

0

[ "3pub", "4efp", "4efq", "4efr", "4iy8", "4iy9", "4pc4", "7wns" ]

8

[ "PUB00096629", "PUB00096630", "PUB00096631" ]

[ "22414538", "26078299", "25379889" ]

[ "Increase of 30K protein in identified motoneurons by hemolymph results in inhibition of programmed cell death in silkworm, Bombyx mori (Lepidoptera, Bombycidae).", "Identification and Characterization of 30 K Protein Genes Found in Bombyx mori (Lepidoptera: Bombycidae) Transcriptome.", "Crystal structure of Bo...

[ 2012, 2015, 2014 ]

3

[]

0

null

[ "Bacteria", "Ditrysia" ]

[ 47, 212 ]

2

[]

0

true

Family

Lepidopteran low molecular weight lipoprotein

Lipoprotein_11

7

IPR004944

4,944

Cyclin-dependent kinase 5 activator

CDK5_activator

Family

2,702

false

These proteins are neuron specific activators of cyclin-dependent kinase 5 (CDK5) [ ]. They form a heterodimer with the catalytic subunit (CDK5) [ ].

[ "GO:0061575", "GO:0016533" ]

[ "cyclin-dependent protein serine/threonine kinase activator activity", "protein kinase 5 complex" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF03261", "PIRSF009324", "PTHR23401" ]

[ "CDK5_activator", "Cdk5_activator", "" ]

[ 2643, 1595, 2653 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-399956", "R-BTA-6804756", "R-CEL-399956", "R-HSA-399956", "R-HSA-6804756", "R-HSA-8862803", "R-HSA-9031628", "R-HSA-9032845", "R-HSA-9768919", "R-MMU-399956", "R-MMU-6804756", "R-RNO-399956", "R-RNO-6804756" ]

[ "REACTOME:R-BTA-399956", "REACTOME:R-BTA-6804756", "REACTOME:R-CEL-399956", "REACTOME:R-HSA-399956", "REACTOME:R-HSA-6804756", "REACTOME:R-HSA-8862803", "REACTOME:R-HSA-9031628", "REACTOME:R-HSA-9032845", "REACTOME:R-HSA-9768919", "REACTOME:R-MMU-399956", "REACTOME:R-MMU-6804756", "REACTOME:R-...

13

[ "1h4l", "1ung", "1unh", "1unl", "3o0g", "7vdp", "7vdq", "7vdr", "7vds", "9hcj" ]

10

[ "PUB00013585", "PUB00033367" ]

[ "8090222", "11882646" ]

[ "A brain-specific activator of cyclin-dependent kinase 5.", "Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor." ]

[ 1994, 2002 ]

2

[]

0

null

[ "Bacteria", "Cotonvirus japonicus", "Eukaryota" ]

[ 6, 1, 2695 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 6, 2, 7, 10, 5 ]

6

true

Family

Cyclin-dependent kinase 5 activator

CDK5_activator

4

IPR004945

4,945

Coronavirus 6B/7B protein

Corona_6B_7B

Family

521

false

The function of the Coronavirus 6B and 7B proteins is not known.

[]

0

[ "PFAM" ]

[ "PF03262" ]

[ "Corona_6B_7B" ]

[ 521 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Alphacoronavirus" ]

[ 521 ]

1

[]

0

true

Family

Coronavirus 6B/7B protein

Corona_6B_7B

8

IPR004946

4,946

Cucumovirus protein 2B

Cucumo_2B

Family

282

false

This family of cucumovirus proteins may be long-distance movement proteins.

[]

0

[ "PFAM" ]

[ "PF03263" ]

[ "Cucumo_2B" ]

[ 282 ]

1

[]

0

[ "2zi0", "3cz3" ]

2

[]

0

[]

0

null

[ "Riboviria" ]

[ 282 ]

1

[]

0

true

Family

Cucumovirus protein 2B

Cucumo_2B

8

IPR004947

4,947

Deoxyribonuclease II

DNase_II

Family

5,673

false

Deoxyribonuclease II ( ) hydrolyses DNA under acidic conditions with a preference for double-stranded DNA typically found in lysosomes in higher eukaryotes. It is also found in a few genera of bacteria in which it is believed to have arisen via horizontal transfer [ ]. It catalyses the endonucleolytic cleavage of DNA t...

[ "GO:0004531", "GO:0006259" ]

[ "deoxyribonuclease II activity", "DNA metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER" ]

[ "PF03265", "PTHR10858" ]

[ "DNase_II", "" ]

[ 5669, 5254 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.22.1", "R-CEL-432720", "R-HSA-432720", "R-MMU-432720", "R-RNO-432720", "R-SSC-432720" ]

[ "EC:3.1.22.1", "REACTOME:R-CEL-432720", "REACTOME:R-HSA-432720", "REACTOME:R-MMU-432720", "REACTOME:R-RNO-432720", "REACTOME:R-SSC-432720" ]

6

[ "5i3e", "5unb" ]

2

[ "PUB00163394" ]

[ "28369538" ]

[ "Structure of acid deoxyribonuclease." ]

[ 2017 ]

1

[]

0

null

[ "Avipoxvirus", "Eukaryota", "Pseudomonadati", "viral metagenome" ]

[ 11, 5567, 80, 15 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 5, 2, 8, 6, 6 ]

6

true

Family

Deoxyribonuclease II

DNase_II

9

IPR004948

4,948

Nucleoside-triphosphatase, THEP1 type

Nuc-triphosphatase_THEP1

Family

3,625

false

This entry represents a family of nucleoside-triphosphatases which have activity towards ATP, GTP, CTP, TTP and UTP and may hydrolyse nucleoside diphosphates with lower efficiency [ ]. It includes proteins from bacteria to human, and the function was determined first in a hyperthermophilic bacterium to be an NTPase [ ]...

[ "GO:0017111" ]

[ "ribonucleoside triphosphate phosphatase activity" ]

[ "molecular_function" ]

1

[ "HAMAP", "PFAM", "PANTHER" ]

[ "MF_00796", "PF03266", "PTHR43146" ]

[ "NTPase_1", "NTPase_1", "" ]

[ 1267, 3617, 3190 ]

3

[ "EC", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "3.6.1.15", "GenProp1617", "GenProp1635", "PWY-6545", "PWY-7184", "PWY-7185", "PWY-7198", "PWY-7210" ]

[ "EC:3.6.1.15", "GP:GenProp1617", "GP:GenProp1635", "METACYC:PWY-6545", "METACYC:PWY-7184", "METACYC:PWY-7185", "METACYC:PWY-7198", "METACYC:PWY-7210" ]

8

[ "1ye8", "2i3b" ]

2

[ "PUB00032635", "PUB00041591", "PUB00055956" ]

[ "15777481", "17291528", "14503925" ]

[ "Crystal structure of THEP1 from the hyperthermophile Aquifex aeolicus: a variation of the RecA fold.", "NMR structure and functional characterization of a human cancer-related nucleoside triphosphatase.", "Thermophile-specific proteins: the gene product of aq_1292 from Aquifex aeolicus is an NTPase." ]

[ 2005, 2007, 2003 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 386, 832, 2301, 106 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 9, 1, 2, 3, 5, 5, 9, 3 ]

8

true

Family

Nucleoside-triphosphatase, THEP1 type

Nuc-triphosphatase_THEP1

8

IPR004950

4,950

Protein of unknown function DUF267, Caenorhabditis species

DUF267_CAE_spp

Family

266

false

This family of proteins, from Caenorhabditis species, have not been characterised though a number are annotated as 'serpentine receptor, class r' proteins.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF03268", "PTHR31930" ]

[ "DUF267", "" ]

[ 263, 238 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Nematoda" ]

[ 266 ]

1

[ "Caenorhabditis elegans" ]

[ 11 ]

1

true

Family

Protein of unknown function DUF267, Caenorhabditis species

DUF267_CAE_spp

5

IPR004951

4,951

Protein of unknown function DUF268, Caenorhabditis species

DUF268_CAE_spp

Family

1,055

false

This family consists of proteins of unknown function found in Caenorhabditis species.

[]

0

[ "PFAM" ]

[ "PF03269" ]

[ "DUF268" ]

[ 1055 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Satyrvirus sp.", "Stenosarchaea group", "metagenomes" ]

[ 315, 700, 1, 7, 32 ]

5

[ "Caenorhabditis elegans" ]

[ 8 ]

1

true

Family

Protein of unknown function DUF268, Caenorhabditis species

DUF268_CAE_spp

1

IPR004952

4,952

NifX-associated nitrogen fixation protein

NifX-assoc_nitrogen_fix

Family

1,150

false

This family includes several proteins of unknown function, which are strictly limited to nitrogen-fixing species, although not universal among them. The gene typically is found next to the nifX gen [ ].

[]

0

[ "PFAM", "PIRSF", "NCBIFAM" ]

[ "PF03270", "PIRSF005788", "TIGR02935" ]

[ "DUF269", "NifK", "" ]

[ 1150, 1093, 1042 ]

3

[ "GP" ]

[ "GenProp0029" ]

[ "GP:GenProp0029" ]

1

[ "3g7p", "3nj2" ]

2

[ "PUB00106722" ]

[ "22289180" ]

[ "Crystal structure of cce_0566 from Cyanothece 51142, a protein associated with nitrogen fixation in the DUF269 family." ]

[ 2012 ]

1

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 1136, 14 ]

2

[]

0

true

Family

NifX-associated nitrogen fixation protein

NifX-assoc_nitrogen_fix

3

IPR004953

4,953

EB1, C-terminal

EB1_C

Domain

8,615

false

A group of microtubule-associated proteins called +TIPs (plus end tracking proteins), including EB1 (end-binding protein 1) family proteins, label growing microtubules ends specifically in diverse organisms and are implicated in spindle dynamics, chromosome segregation, and directing microtubules toward cortical sites....

[ "GO:0008017" ]

[ "microtubule binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PROFILE" ]

[ "PF03271", "PS51230" ]

[ "EB1", "EB1_C" ]

[ 8497, 8586 ]

2

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "PDOC51230", "R-BTA-141444", "R-BTA-2467813", "R-BTA-2500257", "R-BTA-2565942", "R-BTA-380259", "R-BTA-380270", "R-BTA-380284", "R-BTA-380320", "R-BTA-5620912", "R-BTA-5663220", "R-BTA-68877", "R-BTA-8852276", "R-BTA-8854518", "R-BTA-9648025", "R-HSA-141444", "R-HSA-2467813", "R-HS...

[ "PROSITEDOC:PDOC51230", "REACTOME:R-BTA-141444", "REACTOME:R-BTA-2467813", "REACTOME:R-BTA-2500257", "REACTOME:R-BTA-2565942", "REACTOME:R-BTA-380259", "REACTOME:R-BTA-380270", "REACTOME:R-BTA-380284", "REACTOME:R-BTA-380320", "REACTOME:R-BTA-5620912", "REACTOME:R-BTA-5663220", "REACTOME:R-BTA...

70

[ "1txq", "1wu9", "1yib", "1yig", "2hkq", "2hl5", "2r8u", "3gjo", "3mtu", "3mud", "3tq7", "4e61", "4xa1", "4xa3", "4xa6", "5jv3", "5jvm", "5jvp", "5jvr", "5jvs", "5jvu", "5jx1", "5m97", "5m9e", "5n74", "5wlq", "6evi", "6evq", "6pf2", "6pfp", "6yf5", "6ysh"...

36

[ "PUB00032323", "PUB00032655", "PUB00035338", "PUB00035339" ]

[ "15616574", "15699215", "14614826", "16109370" ]

[ "Structural insights into the EB1-APC interaction.", "Structural determinants for EB1-mediated recruitment of APC and spectraplakins to the microtubule plus end.", "A novel localization pattern for an EB1-like protein links microtubule dynamics to endomembrane organization.", "Structural basis for the activat...

[ 2005, 2005, 2003, 2005 ]

4

[]

0

null

[ "Archaeoglobus fulgidus", "Bacteria", "Eukaryota" ]

[ 1, 2, 8612 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 11, 3, 12, 11, 5, 8, 1, 5, 15, 1, 1, 9 ]

12

true

Domain

EB1, C-terminal

EB1_C

3

IPR004954

4,954

Putative mucin/carbohydrate-binding domain

Mucin-bd

Domain

1,633

false

This entry represents a putative binding domain for the substrates of enhancin, and other similar metallopeptidases [ ]. This is not the enzymatically active (peptidase) part of the proteins. The baculovirus enhancin protein, or enhancing factor, is involved in disruption of the peritrophic membrane and fusion of nucle...

[]

0

[ "PFAM" ]

[ "PF03272" ]

[ "Mucin_bdg" ]

[ 1633 ]

1

[]

0

[ "8pmu", "8pn3", "8pn5" ]

3

[ "PUB00019515" ]

[ "9192677" ]

[ "An intestinal mucin is the target substrate for a baculovirus enhancin." ]

[ 1997 ]

1

[]

0

null

[ "Bacteria", "Baculoviridae", "Opisthokonta" ]

[ 1559, 36, 38 ]

3

[]

0

true

Domain

Putative mucin/carbohydrate-binding domain

Mucin-bd

5

IPR004955

4,955

Baculovirus Gp64, envelope glycoprotein

Baculovirus_Gp64

Family

196

false

Gp64 is the major envelope fusion glycoprotein in some, though not all, baculoviruses [ , ]. It is found on the surface of both infected cells and budded virions as a homotrimer, and by determining the viral receptor preferences it defines the host range and infection efficiency. Baculovirus enters its host cells by en...

[ "GO:0044003", "GO:0019031" ]

[ "symbiont-mediated perturbation of host process", "viral envelope" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF03273" ]

[ "Baculo_gp64" ]

[ 196 ]

1

[]

0

[ "3duz", "5xea", "5xeb", "5zkx", "5zl2", "7xym", "8yg6", "8yg8" ]

8

[ "PUB00034715", "PUB00034716", "PUB00034717" ]

[ "16364739", "1279100", "16997010" ]

[ "Conserved molecular systems of the Baculoviridae.", "Identification of viral structural polypeptides of Thogoto virus (a tick-borne orthomyxo-like virus) and functions associated with the glycoprotein.", "Baculovirus display: a multifunctional technology for gene delivery and eukaryotic library development." ]

[ 2006, 1992, 2006 ]

3

[]

0

null

[ "Eukaryota", "Viruses" ]

[ 17, 179 ]

2

[]

0

true

Family

Baculovirus Gp64, envelope glycoprotein

Baculovirus_Gp64

7

IPR004956

4,956

Foamy virus BEL 1/2 protein

Foamy_BEL

Family

70

false

Foamy virus (FV) gene expression is strictly dependent on their transactivator proteins called Bel1/Tas. The presence of a functionally active, internal promoter, besides the conventional LTR promoters, is unique to FVs. The nuclear Bel1/Tas protein of primate prototype FV binds DNA target sites directly and consists o...

[ "GO:0016032", "GO:0045893" ]

[ "viral process", "positive regulation of DNA-templated transcription" ]

[ "biological_process", "biological_process" ]

2

[ "PFAM" ]

[ "PF03274" ]

[ "Foamy_BEL" ]

[ 70 ]

1

[]

0

[]

0

[ "PUB00014952" ]

[ "14972532" ]

[ "Comparative functional characterization of the feline foamy virus transactivator reveals its species specificity." ]

[ 2004 ]

1

[]

0

null

[ "Simiispumavirus" ]

[ 70 ]

1

[]

0

true

Family

Foamy virus BEL 1/2 protein

Foamy_BEL

7

IPR004957

4,957

Gag polyprotein, N-terminal domain

Gag_N

Domain

1,491

false

This is the conserved N-terminal domain of the Gag polyprotein from Foamyviruses (FVs) or Spuma-retroviruses. Gag is the major structural protein required for genome packaging virion assembly, trafficking and egress. This region corresponds to the Env-binding domain containing the cytoplasmic targeting and retention se...

[ "GO:0019076", "GO:0046718", "GO:0075521", "GO:0019028", "GO:0030430", "GO:0042025", "GO:0044163" ]

[ "viral release from host cell", "symbiont entry into host cell", "microtubule-dependent intracellular transport of viral material towards nucleus", "viral capsid", "host cell cytoplasm", "host cell nucleus", "host cytoskeleton" ]

[ "biological_process", "biological_process", "biological_process", "cellular_component", "cellular_component", "cellular_component", "cellular_component" ]

7

[ "PFAM" ]

[ "PF03276" ]

[ "Gag_spuma_N" ]

[ 1491 ]

1

[]

0

[ "4jmr", "4jnh", "8ozk", "8ozl", "8ozm", "8ozn" ]

6

[ "PUB00019593", "PUB00068239", "PUB00068240", "PUB00151567" ]

[ "9261397", "16160174", "12857789", "27829070" ]

[ "Characterization of the genome of feline foamy virus and its proteins shows distinct features different from those of primate spumaviruses.", "N-terminal Gag domain required for foamy virus particle assembly and export.", "Targeting of incoming retroviral Gag to the centrosome involves a direct interaction wit...

[ 1997, 2005, 2003, 2016 ]

4

[]

0

null

[ "Spumaretrovirinae" ]

[ 1491 ]

1

[]

0

true

Domain

Gag polyprotein, N-terminal domain

Gag_N

4

IPR004958

4,958

Herpesvirus UL4

Herpes_UL4

Family

251

false

This is a family of Herpes virus UL4 proteins, which are related to Human herpesvirus 1 (HHV-1), Human herpesvirus 2 (HHV-2), Equid herpesvirus 1 (Equine herpesvirus 1, EHV-1) 58, and Human herpesvirus 3 VZV-32 56 proteins.

[]

0

[ "PFAM" ]

[ "PF03277" ]

[ "Herpes_UL4" ]

[ 251 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Alphaherpesvirinae" ]

[ 251 ]

1

[]

0

true

Family

Herpesvirus UL4

Herpes_UL4

1

IPR004959

4,959

Bacterial effector protein IpgB-like

Bac_effector_IpgB-like

Family

217

false

This family consists of IpgB1 and IpgB2 from Shigella [ ] as well as related proteins TrcA, Map, EspM from Escherichia coli. Members of this family seem to be involved in pathogenicity and have been identified as small GTPases mimicking or activating proteins [ , ].

[]

0

[ "PFAM" ]

[ "PF03278" ]

[ "IpaB_EvcA" ]

[ 217 ]

1

[]

0

[ "3gcg", "3lw8", "3lwn", "3lxr", "3lyq" ]

5

[ "PUB00060837", "PUB00060838", "PUB00060839" ]

[ "18331467", "16413487", "18316224" ]

[ "Subversion of actin dynamics by EspM effectors of attaching and effacing bacterial pathogens.", "Identification of a bacterial type III effector family with G protein mimicry functions.", "IpgB1 and IpgB2, two homologous effectors secreted via the Mxi-Spa type III secretion apparatus, cooperate to mediate pola...

[ 2008, 2006, 2008 ]

3

[]

0

null

[ "Enterobacterales", "Escherichia phage 2B8" ]

[ 216, 1 ]

2

[]

0

true

Family

Bacterial effector protein IpgB-like

Bac_effector_IpgB-like

3

IPR004960

4,960

Bacterial lipid A biosynthesis acyltransferase

LipA_acyltrans

Family

32,235

false

Bacterial lipopolysachharides (LPS) are glycolipids that make up the outer monolayer of the outer membranes of most Gram-negative bacteria. Though LPS molecules are variable, they all show the same general features: an outer polysaccharide which is attached to the lipid component, termed lipid A [ ]. The polysaccharide...

[ "GO:0016740", "GO:0016020" ]

[ "transferase activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM", "PIRSF", "PANTHER", "CDD" ]

[ "PF03279", "PIRSF026649", "PTHR30606", "cd07984" ]

[ "Lip_A_acyltrans", "MsbB", "", "LPLAT_LABLAT-like" ]

[ 31713, 16208, 30890, 31054 ]

4

[ "EC", "GP", "GP", "GP", "GP" ]

[ "2.3.1", "GenProp0204", "GenProp1325", "GenProp1397", "GenProp1647" ]

[ "EC:2.3.1", "GP:GenProp0204", "GP:GenProp1325", "GP:GenProp1397", "GP:GenProp1647" ]

5

[ "5f2t", "5f2z", "5f31", "5f34", "5kn7", "5knk", "5oce", "7ojt" ]

8

[ "PUB00028103", "PUB00033945", "PUB00033946", "PUB00059307" ]

[ "12045108", "9791168", "8894399", "2203778" ]

[ "Lipopolysaccharide endotoxins.", "Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica.", "The lipooligosaccharides of pathogenic gram-negative bacteria.", "Biosynthesis of lipid A in Escherichia coli. Acyl carrier protein-depende...

[ 2002, 1998, 1996, 1990 ]

4

[]

[ "IPR011920", "IPR011921", "IPR014548" ]

0

3

0

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ct1Eo1", "unclassified sequences" ]

[ 8, 31390, 87, 1, 749 ]

5

[ "Escherichia coli (strain K12)" ]

[ 3 ]

1

true

Family

Bacterial lipid A biosynthesis acyltransferase

LipA_acyltrans

8

IPR004961

4,961

Lipase chaperone

Lipase_chaperone

Family

2,029

false

The proteobacterial lipase chaperone is a lipase helper protein which may be involved in the folding of extracellular lipase during its passage through the periplasm [ ].

[ "GO:0051082", "GO:0006457", "GO:0016020" ]

[ "unfolded protein binding", "protein folding", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "PFAM" ]

[ "MF_00790", "PF03280" ]

[ "Lipase_chap", "Lipase_chap" ]

[ 876, 2029 ]

2

[]

0

[ "2es4", "9g8u" ]

2

[ "PUB00054934" ]

[ "8412705" ]

[ "Role of the lipB gene product in the folding of the secreted lipase of Pseudomonas glumae." ]

[ 1993 ]

1

[]

0

null

[ "Arthropoda", "Bacteria", "ecological metagenomes" ]

[ 2, 2023, 4 ]

3

[]

0

true

Family

Lipase chaperone

Lipase_chaperone

7

IPR004963

4,963

Pectinacetylesterase/NOTUM

PAE/NOTUM

Family

11,519

false

This family includes protein Notum from animals and pectinacetylesterase (PAE) from plants. Notum is a carboxylesterase that removes an essential palmitoleate moiety from Wnt proteins. Notum constitutes the first known extracellular protein deacylase [ , ]. PAEs catalyse the deacetylation of pectin, a major compound of...

[ "GO:0016787" ]

[ "hydrolase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER" ]

[ "PF03283", "PTHR21562" ]

[ "PAE", "" ]

[ 11503, 11007 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.1", "R-DME-381426", "R-DME-5362798", "R-DME-8957275", "R-DRE-5362798", "R-HSA-381426", "R-HSA-5362798", "R-HSA-8957275", "R-MMU-381426", "R-MMU-5362798", "R-MMU-8957275" ]

[ "EC:3.1.1", "REACTOME:R-DME-381426", "REACTOME:R-DME-5362798", "REACTOME:R-DME-8957275", "REACTOME:R-DRE-5362798", "REACTOME:R-HSA-381426", "REACTOME:R-HSA-5362798", "REACTOME:R-HSA-8957275", "REACTOME:R-MMU-381426", "REACTOME:R-MMU-5362798", "REACTOME:R-MMU-8957275" ]

11

[ "4uyu", "4uyw", "4uyz", "4uz1", "4uz5", "4uz6", "4uz7", "4uz9", "4uza", "4uzj", "4uzk", "4uzl", "4uzq", "4wbh", "6r8p", "6r8q", "6r8r", "6t2h", "6t2k", "6tr5", "6tr6", "6tr7", "6tuz", "6tv4", "6ysk", "6yuw", "6yuy", "6yv0", "6yv2", "6yv4", "6yxi", "6zuv"...

143

[ "PUB00074557", "PUB00074558", "PUB00074559", "PUB00074560" ]

[ "12026180", "25115560", "25731175", "25771893" ]

[ "An Arabidopsis thaliana pectin acetylesterase gene is upregulated in nematode feeding sites induced by root-knot and cyst nematodes.", "Identification and functional characterization of the distinct plant pectin esterases PAE8 and PAE9 and their deletion mutants.", "Notum deacylates Wnt proteins to suppress si...

[ 2002, 2014, 2015, 2015 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 10, 890, 10604, 15 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 66, 6, 1, 3, 2, 32, 4, 91 ]

8

true

Family

Pectinacetylesterase/NOTUM

PAE/NOTUM

5

IPR004965

4,965

Paralemmin

Family

4,657

false

Paralemmin was identified in the chicken lens as a protein with a molecular weight of 65kDa (isoform 1) and a splice variant of 60kDa (isoform 2). Isoform 2 is predominant during infancy and levels of isoform 1 increase with age. Paralemmin is localised to the plasma membrane of fibre cells, and was not detected in the...

[ "GO:0008360", "GO:0016020" ]

[ "regulation of cell shape", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF03285" ]

[ "Paralemmin" ]

[ 4657 ]

1

[]

0

[]

0

[ "PUB00014953", "PUB00055490", "PUB00098648", "PUB00152824" ]

[ "12874826", "21187075", "18287537", "22855693" ]

[ "Paralemnin of the lens.", "A novel binding protein of single immunoglobulin IL-1 receptor-related molecule: Paralemmin-3.", "Paralemmin-1, a modulator of filopodia induction is required for spine maturation.", "Evolution of the vertebrate paralemmin gene family: ancient origin of gene duplicates suggests dis...

[ 2003, 2011, 2008, 2012 ]

4

[]

[ "IPR024149" ]

0

1

0

[ "Vertebrata" ]

[ 4657 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 28, 17, 20, 20 ]

4

true

Family

Paralemmin

1

IPR004966

4,966

Pox virus Ag35 surface protein

Pox_Ag35

Family

166

false

The Pox virus Ag35 surface protein is an evelope protein known as protein H5 or Late transcription elongation factor OPG110. It is involved in the co-transcriptional or post-transcriptional endoribonucleolytic cleavage that generates sequence-homogeneous 3' ends during late transcription and in postreplicative transcri...

[ "GO:0019031" ]

[ "viral envelope" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF03286" ]

[ "Pox_Ag35" ]

[ 166 ]

1

[]

0

[ "8wpe", "8wpf", "8wpk", "8wpp" ]

4

[ "PUB00103563", "PUB00103564" ]

[ "20206959", "25855734" ]

[ "Vaccinia H5 is a multifunctional protein involved in viral DNA replication, postreplicative gene transcription, and virion morphogenesis.", "Genetic Confirmation that the H5 Protein Is Required for Vaccinia Virus DNA Replication." ]

[ 2010, 2015 ]

2

[]

0

null

[ "Pajaroellobacter abortibovis", "Plakobranchidae", "Poxviridae" ]

[ 1, 3, 162 ]

3

[]

0

true

Family

Pox virus Ag35 surface protein

Pox_Ag35

8

IPR004968

4,968

DNA primase/nucleoside triphosphatase, C-terminal

DNA_primase/NTPase_C

Domain

4,207

false

This domain is found at the C terminus of phage P4 alpha protein and related proteins. Phage P4 DNA replication depends on the product of the alpha gene, which has origin recognition ability, DNA helicase activity, and DNA primase activity. The structure of the protein can be summarised as follows: The N terminus provi...

[]

0

[ "PFAM" ]

[ "PF03288" ]

[ "Pox_D5" ]

[ 4207 ]

1

[ "EC", "METACYC" ]

[ "3.6.4.-", "PWY-7250" ]

[ "EC:3.6.4.-", "METACYC:PWY-7250" ]

2

[ "1ka8", "7ola", "7om0", "8apl", "8apm", "8hwa", "8hwb", "8hwc", "8hwd", "8hwe", "8hwf", "8hwg", "8hwh", "8wgy", "8wgz", "8wh0", "8wh2", "8wh3", "8wh4", "8wh6", "8xj6", "8xj7", "8xj8", "9ily", "9ilz", "9im0", "9im1", "9im2", "9im3" ]

29

[ "PUB00020151", "PUB00035847" ]

[ "7636979", "7635818" ]

[ "The vaccinia virus D5 protein, which is required for DNA replication, is a nucleic acid-independent nucleoside triphosphatase.", "Domain structure of phage P4 alpha protein deduced by mutational analysis." ]

[ 1995, 1995 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 105, 3401, 316, 321, 64 ]

5

[]

0

true

Domain

DNA primase/nucleoside triphosphatase, C-terminal

DNA_primase/NTPase_C

4

IPR004969

4,969

Poxvirus I1

Poxvirus_I1

Family

132

false

This entry represents a family of proteins from poxvirus, including the vaccinia virus I1L (Late) encoded protein, which is also called Telomere-binding protein OPG077. It is a DNA-binding protein which binds to the hairpin form of the viral telomeric sequence. Required for the production of mature virions (MV) [ , ].

[]

0

[ "PFAM", "PIRSF" ]

[ "PF03289", "PIRSF015625" ]

[ "Pox_I1", "VAC_I1L" ]

[ 132, 126 ]

2

[]

0

[]

0

[ "PUB00010106", "PUB00015780" ]

[ "11581377", "9371587" ]

[ "Vaccinia virus telomeres: interaction with the viral I1, I6, and K4 proteins.", "The vaccinia virus I1 protein is essential for the assembly of mature virions." ]

[ 2001, 1997 ]

2

[]

0

null

[ "Poxviridae" ]

[ 132 ]

1

[]

0

true

Family

Poxvirus I1

Poxvirus_I1

2

IPR004970

4,970

Peptidase C57, Vaccinia virus protein I7

Peptidase_C57

Family

152

false

This is a group of cysteine peptidases which constitute MEROPS peptidase family C57 (clan CE). The type example is vaccinia virus I7 processing peptidase (vaccinia virus). Protein I7, also known as Core protease OPG082, is expressed in the late phase of infection [ ]. This protein is responsible for processing most or ...

[]

0

[ "PFAM" ]

[ "PF03290" ]

[ "Peptidase_C57" ]

[ 152 ]

1

[ "EC" ]

[ "3.4.22.-" ]

[ "EC:3.4.22.-" ]

1

[ "9jal", "9jam", "9jan", "9jaq", "9kqv", "9kr6", "9ku2", "9ku9", "9lik", "9lil", "9lim" ]

11

[ "PUB00007233", "PUB00011704", "PUB00020025", "PUB00030423", "PUB00076953", "PUB00103565", "PUB00103566" ]

[ "2835495", "11517925", "9891971", "14725770", "7044372", "12163618", "15163727" ]

[ "Sequence and transcriptional analysis of the vaccinia virus HindIII I fragment.", "Evolutionary lines of cysteine peptidases.", "Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases.", "The structure of sortase B, a cysteine t...

[ 1988, 2001, 1998, 2004, 1982, 2002, 2004 ]

7

[]

0

null

[ "Eukaryota", "Poxviridae" ]

[ 3, 149 ]

2

[]

0

true

Family

Peptidase C57, Vaccinia virus protein I7

Peptidase_C57

1

IPR004971

4,971

mRNA (guanine-N(7))-methyltransferase domain

mRNA_G-N7_MeTrfase_dom

Domain

6,806

false

This entry represents mRNA (guanine-N(7))-methyltransferase, which can either be found as a single domain protein, or as a domain within the mRNA-capping enzyme catalytic subunit. mRNA (guanine-N(7))-methyltransferase methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. It binds RNA conta...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF03291", "PS51562" ]

[ "mRNA_G-N7_MeTrfase", "RNA_CAP0_MT" ]

[ 6761, 6442 ]

2

[ "EC", "GP", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.1.1.56", "GenProp1354", "PWY-7375", "R-CEL-72086", "R-CEL-77075", "R-DME-72086", "R-DME-77075", "R-DRE-72086", "R-DRE-77075", "R-HSA-167160", "R-HSA-72086", "R-HSA-77075", "R-MMU-72086", "R-MMU-77075", "R-RNO-72086", "R-RNO-77075", "R-SCE-72086", "R-SCE-77075", "R-SPO-72086", ...

[ "EC:2.1.1.56", "GP:GenProp1354", "METACYC:PWY-7375", "REACTOME:R-CEL-72086", "REACTOME:R-CEL-77075", "REACTOME:R-DME-72086", "REACTOME:R-DME-77075", "REACTOME:R-DRE-72086", "REACTOME:R-DRE-77075", "REACTOME:R-HSA-167160", "REACTOME:R-HSA-72086", "REACTOME:R-HSA-77075", "REACTOME:R-MMU-72086"...

21

[ "1ri1", "1ri2", "1ri3", "1ri4", "1ri5", "1z3c", "2hv9", "2vdw", "3bgv", "3epp", "4ckb", "4ckc", "4cke", "5e8j", "5e9j", "5e9w", "6rfl", "6rie", "7d8u", "7z05", "7z2j", "8p0j", "8p0k", "8p0n", "8q69", "8q8g", "8q9w", "8rqk", "8y2z", "8ze4", "9fq6", "9mg0"...

38

[ "PUB00027904", "PUB00058114", "PUB00058115", "PUB00058116", "PUB00058117", "PUB00058118", "PUB00100699" ]

[ "7623811", "10679253", "10347220", "9790902", "9705270", "22099306", "24607143" ]

[ "Yeast mRNA cap methyltransferase is a 50-kilodalton protein encoded by an essential gene.", "Cloning and characterization of mRNA capping enzyme and mRNA (Guanine-7-)-methyltransferase cDNAs from Xenopus laevis.", "Characterization of human, Schizosaccharomyces pombe, and Candida albicans mRNA cap methyltransf...

[ 1995, 2000, 1999, 1998, 1998, 2011, 2014 ]

7

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 2, 6239, 303, 262 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 9, 1, 1, 1, 8, 3, 1, 3, 9, 1, 1, 28 ]

12

true

Domain

mRNA (guanine-N(7))-methyltransferase domain

mRNA_G-N7_MeTrfase_dom

5

IPR004972

4,972

Major core protein 4b

P4B

Family

921

false

This family includes the major core protein 4b from Vaccinia virus, also known as Major core protein OPG129. It is a major component of the virion core that undergoes proteolytic processing during the immature virion (IV) to mature virion (MV) transition. It is essential for the formation of a structurally normal core ...

[]

0

[ "PFAM" ]

[ "PF03292" ]

[ "Pox_P4B" ]

[ 921 ]

1

[]

0

[]

0

[ "PUB00066842", "PUB00066843" ]

[ "2999438", "1993877" ]

[ "Transcriptional and translational mapping and nucleotide sequence analysis of a vaccinia virus gene encoding the precursor of the major core polypeptide 4b.", "Proteolytic maturation of vaccinia virus core proteins: identification of a conserved motif at the N termini of the 4b and 25K virion proteins." ]

[ 1985, 1991 ]

2

[]

0

null

[ "Macrosiphum euphorbiae", "Nucleocytoviricota", "metagenomes" ]

[ 1, 910, 10 ]

3

[]

0

true

Family

Major core protein 4b

P4B

5

IPR004973

4,973

DNA-directed RNA polymerase, 18kDa subunit, poxviral

DNA-dir_RNA_pol_18kDa_poxviral

Family

120

false

DNA-directed RNA polymerases (also known as DNA-dependent RNA polymerases) are responsible for the polymerisation of ribonucleotides into a sequence complementary to the template DNA. In eukaryotes, there are three different forms of DNA-directed RNA polymerases transcribing different sets of genes. Most RNA polymerase...

[ "GO:0003677", "GO:0003899", "GO:0019083" ]

[ "DNA binding", "DNA-directed RNA polymerase activity", "viral transcription" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF03293" ]

[ "Pox_RNA_pol" ]

[ 120 ]

1

[ "EC" ]

[ "2.7.7.6" ]

[ "EC:2.7.7.6" ]

1

[ "6rfl", "6ric", "6rid", "6rie", "7amv", "7aof", "7aoh", "7aoz", "7ap8", "7ap9", "8c8h", "8p0j", "8p0k", "8p0n", "8rqk", "9ex9", "9fpy", "9fq6" ]

18

[ "PUB00000061", "PUB00033173" ]

[ "3052291", "10499798" ]

[ "Structure and function of bacterial sigma factors.", "Crystal structure of Thermus aquaticus core RNA polymerase at 3.3 A resolution." ]

[ 1988, 1999 ]

2

[]

0

null

[ "Poxviridae" ]

[ 120 ]

1

[]

0

true

Family

DNA-directed RNA polymerase, 18kDa subunit, poxviral

DNA-dir_RNA_pol_18kDa_poxviral

2

IPR004974

4,974

RNA polymerase-associated transcription specificity factor Rap94

Pox_Rap94

Family

229

false

The Poxvirus RNA polymerase-associated transcription specificity factor Rap94 associates with RNA polymerase and may mediate binding of the core polymerase to VetF. It is required for transcription of early genes.

[ "GO:0003700" ]

[ "DNA-binding transcription factor activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF03294" ]

[ "Pox_Rap94" ]

[ 229 ]

1

[]

0

[ "6rfl", "6ric", "7amv", "7aof", "7aoh", "7aoz", "7ap8", "7ap9", "8c8h", "8rqk", "9fpy", "9fq6" ]

12

[]

0

[]

0

null

[ "Poxviridae" ]

[ 229 ]

1

[]

0

true

Family

RNA polymerase-associated transcription specificity factor Rap94

Pox_Rap94

1

IPR004975

4,975

Poxvirus VLTF2, trans-activator

Poxvirus_VLTF2

Family

107

false

Late transcription factor VLTF-2, acts with RNA polymerase to initiate transcription from late gene promoters [ ].

[]

0

[ "PFAM" ]

[ "PF03295" ]

[ "Pox_TAA1" ]

[ 107 ]

1

[]

0

[]

0

[ "PUB00020164" ]

[ "2344616" ]

[ "Role of DNA replication in vaccinia virus gene expression: a naked template is required for transcription of three late trans-activator genes." ]

[ 1990 ]

1

[]

0

null

[ "Poxviridae" ]

[ 107 ]

1

[]

0

true

Family

Poxvirus VLTF2, trans-activator

Poxvirus_VLTF2

8

IPR004976

4,976

Poly(A) polymerase catalytic subunit, Poxvirus

PolyA_pol_cat_Poxvir

Family

149

false

Poly(A) polymerase ( ) catalyses template-independent extension of the 3'-end of a DNA or RNA strand by one nucleotide at a time. The Poxvirus enzyme creates the 3'(poly)A tail of mRNAs, and is a heterodimer of a catalytic and a regulatory subunit. This is the catalytic subunit.

[ "GO:1990817", "GO:0006397" ]

[ "poly(A) RNA polymerase activity", "mRNA processing" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF", "CDD" ]

[ "PIRSF015693", "cd20919" ]

[ "VAC-48L_nuct", "polyA_pol_Pox" ]

[ 141, 149 ]

2

[ "EC" ]

[ "2.7.7.19" ]

[ "EC:2.7.7.19" ]

1

[ "2ga9", "2gaf", "3er8", "3er9", "3erc", "3owg" ]

6

[]

0

[]

0

null

[ "Poxviridae" ]

[ 149 ]

1

[]

0

true

Family

Poly(A) polymerase catalytic subunit, Poxvirus

PolyA_pol_cat_Poxvir

8

IPR004977

4,977

Small ribosomal subunit protein eS25

Ribosomal_eS25

Family

6,197

false

This entry represents eS25 ribosomal protein, found in eukaryotes and archaea, that is a component of the 40S ribosomal subunit. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorpo...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF03297", "PTHR12850" ]

[ "Ribosomal_S25", "" ]

[ 6189, 5764 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-1799339", "R-BTA-6791226", "R-BTA-72649", "R-BTA-72689", "R-BTA-72695", "R-BTA-72702", "R-BTA-72706", "R-BTA-975956", "R-BTA-975957", "R-CEL-156827", "R-CEL-1799339", "R-CEL-72649", "R-CEL-72689", "R-CEL-72695", "R-CEL-72702", "R-CEL-72706", "R-CEL-975956", ...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-1799339", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-72649", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72695", "REACTOME:R-BTA-72702", "REACTOME:R-BTA-72706", "REACTOME:R-BTA-975956", "REACTOME:R-BTA-975957", "REACTOME:R-CEL-156827", "REACTOME:R-CEL-179933...

99

[ "3j6x", "3j6y", "3j77", "3j78", "3j7a", "3j7p", "3j7r", "3j80", "3j81", "3jag", "3jah", "3jai", "3jaj", "3jam", "3jan", "3jap", "3jbn", "3jbo", "3jbp", "4bts", "4d5l", "4d61", "4kzx", "4kzy", "4kzz", "4u3m", "4u3n", "4u3u", "4u4n", "4u4o", "4u4q", "4u4r"...

537

[ "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "11297922", "11290319", "11114498" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins." ]

[ 2001, 2001, 2000 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 226, 6, 5958, 7 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 13, 1, 1, 2, 1, 3, 1, 11, 7, 2, 2, 15 ]

12

true

Family

Small ribosomal subunit protein eS25

Ribosomal_eS25

7

IPR004978

4,978

Stanniocalcin

Family

2,732

false

Stanniocalcin (STC) is a calcium-and phosphate-regulating hormone produced in bony fish by the corpuscles of Stannius, which are located close to the kidney. It is a major antihypercalcemic hormone in fish. Recent results suggest that the biological repertoires of STCs in mammals will be considerably larger than in fis...

[ "GO:0005179", "GO:0005576" ]

[ "hormone activity", "extracellular region" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF03298", "PTHR11245" ]

[ "Stanniocalcin", "" ]

[ 2451, 2661 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-381426", "R-HSA-8957275", "R-MMU-381426", "R-MMU-8957275", "R-RNO-381426", "R-RNO-8957275" ]

[ "REACTOME:R-HSA-381426", "REACTOME:R-HSA-8957275", "REACTOME:R-MMU-381426", "REACTOME:R-MMU-8957275", "REACTOME:R-RNO-381426", "REACTOME:R-RNO-8957275" ]

6

[ "7y5q", "8a7d", "8a7e", "8hgh" ]

4

[ "PUB00020377" ]

[ "11033047" ]

[ "Singular contributions of fish neuroendocrinology to mammalian regulatory peptide research." ]

[ 2000 ]

1

[]

0

null

[ "Eukaryota", "Pseudomonadati" ]

[ 2718, 14 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 5, 9, 11, 4 ]

5

true

Family

Stanniocalcin

6

IPR004979

4,979

Transcription factor AP-2

TF_AP2

Family

7,384

false

Activator protein-2 (AP-2) transcription factors constitute a family of closely related and evolutionarily conserved proteins that bind to the DNA consensus sequence 5'-GCCNNNGGC-3' and stimulate target gene transcription [ , ]. Five different isoforms of AP-2 have been identified in mammals, termed AP-2 alpha, beta, g...

[ "GO:0003700", "GO:0006355", "GO:0005634" ]

[ "DNA-binding transcription factor activity", "regulation of DNA-templated transcription", "nucleus" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PANTHER" ]

[ "PTHR10812" ]

[ "" ]

[ 7384 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-8864260", "R-BTA-8866904", "R-BTA-8866907", "R-BTA-8869496", "R-BTA-9834899", "R-CEL-3232118", "R-CEL-8866904", "R-CEL-8866907", "R-CEL-9834899", "R-CFA-8866904", "R-CFA-8866907", "R-CFA-9834899", "R-DRE-8866907", "R-HSA-3232118", "R-HSA-8864260", "R-HSA-8866904", "R-HSA-88669...

[ "REACTOME:R-BTA-8864260", "REACTOME:R-BTA-8866904", "REACTOME:R-BTA-8866907", "REACTOME:R-BTA-8869496", "REACTOME:R-BTA-9834899", "REACTOME:R-CEL-3232118", "REACTOME:R-CEL-8866904", "REACTOME:R-CEL-8866907", "REACTOME:R-CEL-9834899", "REACTOME:R-CFA-8866904", "REACTOME:R-CFA-8866907", "REACTOM...

38

[ "8j0k", "8j0l", "8j0q", "8j0r" ]

4

[ "PUB00010264", "PUB00010265", "PUB00010332", "PUB00010369", "PUB00010381", "PUB00099637", "PUB00099638" ]

[ "1998122", "2010091", "9632718", "10864206", "11137286", "27176626", "11694877" ]

[ "Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins.", "Analysis of the DNA-binding and activation properties of the human transcription factor AP-2.", "Loss of AP-2 results in up-regulation of MCAM/MUC18 and an increase in tumor growth and metastasis of human...

[ 1991, 1991, 1998, 2000, 2000, 2016, 2001 ]

7

[]

[ "IPR008122", "IPR008123" ]

0

2

0

[ "Eukaryota" ]

[ 7384 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 51, 6, 14, 20, 25 ]

6

true

Family

Transcription factor AP-2

TF_AP2

4

IPR004980

4,980

Tenuivirus movement protein, NS4

Tenui_NS4

Family

89

false

NS4 (also known as pc4) transports viral genome to neighbouring plant cells directly through plasmosdesmata, without any budding. It allows efficient cell to cell propagation, by bypassing the host cell wall barrier [ ].

[ "GO:0046740" ]

[ "transport of virus in host, cell to cell" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF03300" ]

[ "Tenui_NS4" ]

[ 89 ]

1

[]

0

[]

0

[ "PUB00055606" ]

[ "18818319" ]

[ "Identification of a movement protein of the tenuivirus rice stripe virus." ]

[ 2008 ]

1

[]

0

null

[ "Henosepilachna vigintioctopunctata", "Phenuiviridae" ]

[ 1, 88 ]

2

[]

0

true

Family

Tenuivirus movement protein, NS4

Tenui_NS4

2

IPR004981

4,981

Tryptophan 2,3-dioxygenase

Trp_2_3_dOase

Family

11,472

false

This is a family of tryptophan 2,3-dioxygenase ( ) enzymes involved in tryptophan metabolism, which catalyses the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring [ ].

[ "GO:0004833", "GO:0020037", "GO:0019441" ]

[ "L-tryptophan 2,3-dioxygenase activity", "heme binding", "L-tryptophan catabolic process to L-kynurenine" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "HAMAP", "PFAM", "PANTHER" ]

[ "MF_01972", "PF03301", "PTHR10138" ]

[ "T23O", "Trp_dioxygenase", "" ]

[ 8352, 11378, 11400 ]

3

[ "EC", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.13.11.11", "GenProp1503", "R-BTA-71240", "R-CEL-71240", "R-DDI-71240", "R-DME-71240", "R-DRE-71240", "R-HSA-71240", "R-MMU-71240", "R-RNO-71240", "R-XTR-71240" ]

[ "EC:1.13.11.11", "GP:GenProp1503", "REACTOME:R-BTA-71240", "REACTOME:R-CEL-71240", "REACTOME:R-DDI-71240", "REACTOME:R-DME-71240", "REACTOME:R-DRE-71240", "REACTOME:R-HSA-71240", "REACTOME:R-MMU-71240", "REACTOME:R-RNO-71240", "REACTOME:R-XTR-71240" ]

11

[ "1yw0", "2nox", "2nw7", "2nw8", "2nw9", "3bk9", "3e08", "4hka", "4pw8", "5ti9", "5tia", "6a4i", "6pyy", "6pyz", "6ud5", "6vbn", "7lu7", "7p46", "7ui3", "8qv7", "8r5q", "8r5r", "8vtq", "8vug", "8vzv", "8w1h", "8w2k", "9at2", "9b17", "9b1q", "9esd", "9esf"...

35

[ "PUB00064805" ]

[ "17212352" ]

[ "Biochemical mechanisms leading to tryptophan 2,3-dioxygenase activation." ]

[ 2007 ]

1

[]

[ "IPR017485" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 25, 9319, 1960, 168 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 7, 3, 3, 3 ]

6

true

Family

Tryptophan 2,3-dioxygenase

Trp_2_3_dOase

1

IPR004982

4,982

WTF family

WTF

Family

135

false

This Schizosaccharomyces family consists of post-meiotic segregation distorting elements (meiotic drivers). Meiotic drivers are selfish genes that break Mendel's law by skewing transmission rates to their own advantage, thereby contributing to reproductive isolation [ , , , ]. WTF family includes diverse meiotic driver...

[ "GO:0110134" ]

[ "meiotic drive" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF03303" ]

[ "WTF" ]

[ 135 ]

1

[]

0

[]

0

[ "PUB00086062", "PUB00086063", "PUB00086064", "PUB00097202", "PUB00097203" ]

[ "28631612", "28631610", "28631611", "32032353", "32790622" ]

[ "wtf genes are prolific dual poison-antidote meiotic drivers.", "A large gene family in fission yeast encodes spore killers that subvert Mendel's law.", "The gene family that cheats Mendel.", "Dramatically diverse Schizosaccharomyces pombe wtf meiotic drivers all display high gamete-killing efficiency.", "A...

[ 2017, 2017, 2017, 2020, 2020 ]

5

[]

0

null

[ "Schizosaccharomyces" ]

[ 135 ]

1

[ "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 17 ]

1

true

Family

WTF family

WTF

5

IPR004983

4,983

Mlp lipoprotein

Mlp

Family

360

false

The Mlp (for Multicopy Lipoprotein) family of lipoproteins is found in Borrelia species [ ]. These proteins were previously known as 2.9 lipoprotein genes [ ]. These surface expressed genes may represent new candidate vaccinogens for Lyme disease [ ]. Members of this family generally are downstream of four ORFs called ...

[]

0

[ "PFAM" ]

[ "PF03304" ]

[ "Mlp" ]

[ 360 ]

1

[]

0

[ "6qbi" ]

1

[ "PUB00007234", "PUB00007235" ]

[ "9488385", "10531261" ]

[ "A monoclonal antibody generated by antigen inoculation via tick bite is reactive to the Borrelia burgdorferi Rev protein, a member of the 2.9 gene family locus.", "Identification, characterization, and expression of three new members of the Borrelia burgdorferi Mlp (2.9) lipoprotein gene family." ]

[ 1998, 1999 ]

2

[]

0

null

[ "Bacteria" ]

[ 360 ]

1

[]

0

true

Family

Mlp lipoprotein

Mlp

1

IPR004984

4,984

Mycoplasma lipoprotein, central domain

Mycoplasma_lipoprotein_cen_dom

Domain

265

false

This domain is found along with a C-terminal domain ( ) in a group of Mycoplasma lipoproteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF03305" ]

[ "Lipoprotein_X" ]

[ 265 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Mycoplasmatota" ]

[ 265 ]

1

[]

0

true

Domain

Mycoplasma lipoprotein, central domain

Mycoplasma_lipoprotein_cen_dom

8

IPR004985

4,985

Adenovirus E3-15

Adeno_E3-15

Family

225

false

Adenoviruses have evolved multiple mechanisms to evade the host immune response. Several of the immunomodulatory proteins are encoded in early transcription unit 3 (E3) of human adenoviruses (Ads). These proteins appear to control viral interactions with the host [ ]. This entry represents the E3_15 family, including p...

[ "GO:0052031" ]

[ "symbiont-mediated perturbation of host defense response" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF03307" ]

[ "Adeno_E3_15_3" ]

[ 225 ]

1

[]

0

[]

0

[ "PUB00009472", "PUB00054928" ]

[ "8627757", "2304142" ]

[ "Early region 3 of adenovirus type 19 (subgroup D) encodes an HLA-binding protein distinct from that of subgroups B and C.", "A protein serologically and functionally related to the group C E3 14,700-kilodalton protein is found in multiple adenovirus serotypes." ]

[ 1996, 1990 ]

2

[]

0

null

[ "Mastadenovirus" ]

[ 225 ]

1

[]

0

true

Family

Adenovirus E3-15

Adeno_E3-15

5

IPR004986

4,986

Caulimovirus virion-associated protein

Caulimo_virion-assoc

Family

119

false

The gene III product of cauliflower mosaic virus (CaMV) is known as virion-associated protein or P3 [ ], which is tightly associated with the virus particles and has a regulatory function in the virus infection cycle. P3 decorate the virions; its N-terminal domain forms an antiparallel α-helical coiled-coil network at ...

[ "GO:0003677" ]

[ "DNA binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF03310" ]

[ "Cauli_DNA-bind" ]

[ 119 ]

1

[]

0

[ "3f6n", "3k4t" ]

2

[ "PUB00069646", "PUB00069648", "PUB00099091" ]

[ "16453711", "11324752", "20181714" ]

[ "The gene III product (P15) of cauliflower mosaic virus is a DNA-binding protein while an immunologically related P11 polypeptide is associated with virions.", "The product of ORF III in cauliflower mosaic virus interacts with the viral coat protein through its C-terminal proline rich domain.", "Structural insi...

[ 1986, 2001, 2010 ]

3

[]

0

null

[ "Caulimovirus", "Eukaryota" ]

[ 98, 21 ]

2

[]

0

true

Family

Caulimovirus virion-associated protein

Caulimo_virion-assoc

2

IPR004987

4,987

DUF272, N-terminal domain

DUF272_N

Domain

152

false

This domain is mainly found in proteins from Caenorhabditis species and has no known function.

[]

0

[ "PFAM" ]

[ "PF03312" ]

[ "DUF272" ]

[ 152 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Rhabditomorpha" ]

[ 152 ]

1

[ "Caenorhabditis elegans" ]

[ 12 ]

1

true

Domain

DUF272, N-terminal domain

DUF272_N

8

IPR004988

4,988

Protein of unknown function DUF273

DUF273

Family

1,439

false

This is a family of proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF03314" ]

[ "DUF273" ]

[ 1439 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "viral metagenome" ]

[ 4, 1430, 5 ]

3

[ "Caenorhabditis elegans" ]

[ 12 ]

1

true

Family

Protein of unknown function DUF273

DUF273

4

IPR004990

4,990

ELF protein

ELF

Family

102

false

This is a family of hypothetical proteins from cereal crops.

[]

0

[ "PFAM" ]

[ "PF03317" ]

[ "ELF" ]

[ 102 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Poaceae" ]

[ 102 ]

1

[ "Oryza sativa subsp. japonica" ]

[ 2 ]

1

true

Family

ELF protein

ELF

9

IPR004991

4,991

Aerolysin-like toxin

Aerolysin-like

Family

2,000

false

This family appears to be distantly related to . It includes toxins from bacteria, such as Clostridium epsilon toxin ETX [ ], and from eukaryotes, such as the hydralysin-1 from Hydra viridissima [ ].

[]

0

[ "PFAM" ]

[ "PF03318" ]

[ "ETX_MTX2" ]

[ 2000 ]

1

[]

0

[ "1uyj", "1w3a", "1w3f", "1w3g", "2d42", "3zjx", "4pkm", "4rhz", "5hd2", "5zu4", "6iul", "6rb9", "7ml9", "8hx3" ]

14

[ "PUB00031944", "PUB00098584" ]

[ "15258571", "12885226" ]

[ "Clostridium perfringens epsilon-toxin shows structural similarity to the pore-forming toxin aerolysin.", "Hydralysin, a novel animal group-selective paralytic and cytolytic protein from a noncnidocystic origin in hydra." ]

[ 2004, 2003 ]

2

[]

[ "IPR009208", "IPR009209", "IPR011218" ]

0

3

0

[ "Bacteria", "Caudoviricetes", "Eukaryota", "bioreactor metagenome" ]

[ 558, 4, 1437, 1 ]

4

[ "Caenorhabditis elegans", "Danio rerio" ]

[ 4, 4 ]

2

true

Family

Aerolysin-like toxin

Aerolysin-like

1

IPR004992

4,992

Ethanolamine utilization protein EutN/carboxysome shell vertex protein CcmL

EutN_CcmL

Family

4,882

false

This entry represents a family of related bacterial proteins with roles in ethanolamine and carbon dioxide metabolism. The ethanolamine utilization protein EutN is involved in the cobalamin-dependent degradation of ethanolamine [ ]. The crystal structure of EutN contains a central five-stranded β-barrel, with an α-heli...

[ "GO:0031469" ]

[ "bacterial microcompartment" ]

[ "cellular_component" ]

1

[ "PFAM", "PROFILE", "PANTHER", "CDD" ]

[ "PF03319", "PS51932", "PTHR36539", "cd01614" ]

[ "EutN_CcmL", "BMV", "", "EutN_CcmL" ]

[ 4878, 4879, 4675, 4237 ]

4

[ "GP" ]

[ "GenProp0292" ]

[ "GP:GenProp0292" ]

1

[ "2hd3", "2qw7", "2rcf", "2z9h", "4i7a", "4jvz", "4jw0", "4n8f", "4n8x", "5l37", "5v74", "6jy5", "6mzx", "6mzy", "6owf", "6owg", "6qn1", "7ckb", "7ckc", "7wkc", "8b0y", "8b11", "8b12", "8wxb", "8yvc", "8yvd", "8yve", "8yvf", "8yvi", "9f0h", "9gvc", "9gw1"...

32

[ "PUB00009955", "PUB00014338", "PUB00015063", "PUB00015066", "PUB00015068", "PUB00021036", "PUB00035324", "PUB00044058", "PUB00044059", "PUB00046650", "PUB00049169", "PUB00074202", "PUB00079630", "PUB00079631", "PUB00079632", "PUB00079633", "PUB00079634", "PUB00079635", "PUB000796...

[ "10464203", "9891798", "11722879", "12923081", "14729686", "16081736", "15516577", "12554704", "18258595", "17588214", "18292340", "19172747", "19177356", "18248510", "17511640", "18937343", "17578868", "16525780", "18679172", "15862091", "18974784", "17897412", "18332146...

[ "The 17-gene ethanolamine (eut) operon of Salmonella typhimurium encodes five homologues of carboxysome shell proteins.", "Something from almost nothing: carbon dioxide fixation in chemoautotrophs.", "Microcompartments in prokaryotes: carboxysomes and related polyhedra.", "Protein content of polyhedral organe...

[ 1999, 1998, 2001, 2003, 2004, 2005, 2004, 2003, 2008, 2007, 2008, 2008, 2009, 2008, 2007, 2008, 2008, 2006, 2008, 2005, 2008, 2007, 2008, 2008, 2007, 1973, 2006, 2006, 2006 ]

29

[]

[ "IPR014076", "IPR014077", "IPR046387" ]

0

3

0

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 4731, 10, 141 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Ethanolamine utilization protein EutN/carboxysome shell vertex protein CcmL

EutN_CcmL

3

IPR004993

4,993

GH3 family

GH3

Family

16,698

false

GH3 protein was first isolated from Glycine max (soybean) as an early auxin-responsive gene [ , ]. Later, several plant GH3 family proteins have been identified and classified into three groups: group I proteins synthesise JA-amino acid conjugates [ ], group II proteins produce indole-3-acetic acid (IAA) conjugates [ ]...

[]

0

[ "PANTHER" ]

[ "PTHR31901" ]

[ "" ]

[ 16698 ]

1

[ "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "...

[ "6.3.2.-", "GenProp1490", "PWY-6289", "PWY-6374", "PWY-6378", "PWY-6379", "PWY-6409", "PWY-6574", "PWY-7510", "PWY-7533", "PWY-7542", "PWY-7543", "PWY-7549", "PWY-7555", "PWY-7556", "PWY-7561", "PWY-7563", "PWY-7565", "PWY-7569", "PWY-7570", "PWY-7571", "PWY-7577", "PWY-7...

[ "EC:6.3.2.-", "GP:GenProp1490", "METACYC:PWY-6289", "METACYC:PWY-6374", "METACYC:PWY-6378", "METACYC:PWY-6379", "METACYC:PWY-6409", "METACYC:PWY-6574", "METACYC:PWY-7510", "METACYC:PWY-7533", "METACYC:PWY-7542", "METACYC:PWY-7543", "METACYC:PWY-7549", "METACYC:PWY-7555", "METACYC:PWY-755...

45

[ "4b2g", "4epl", "4epm", "4eq4", "4eql", "4ewv", "4l39", "5ech", "5eci", "5eck", "5ecl", "5ecm", "5ecn", "5eco", "5ecp", "5ecq", "5ecr", "5gzz", "5kod", "6avh", "6e1q", "6oms", "7dk8", "7vka", "9fwd", "9fxd" ]

26

[ "PUB00074659", "PUB00074660", "PUB00077101", "PUB00077102", "PUB00097882" ]

[ "21619871", "4041007", "15659623", "19189963", "22016342" ]

[ "OsJAR1 and OsJAR2 are jasmonyl-L-isoleucine synthases involved in wound- and pathogen-induced jasmonic acid signalling.", "Rapid induction of selective transcription by auxins.", "Characterization of an Arabidopsis enzyme family that conjugates amino acids to indole-3-acetic acid.", "Arabidopsis GH3.12 (PBS3...

[ 2011, 1985, 2005, 2009, 2011 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 11, 6430, 10143, 2, 112 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 97, 5, 3, 4, 36, 1, 60 ]

7

true

Family

GH3 family

GH3

8

IPR004995

4,995

Bacillus/Clostridium Ger spore germination protein

Spore_Ger

Family

15,563

false

Dormant Bacillus subtilis spores germinate in the presence of particular nutrients called germinants. The spores are thought to recognise germinants through receptor proteins encoded by the gerA family of operons, which includes gerA, gerB, and gerK [ ]. The GerA proteins are predicted to be membrane associated.

[ "GO:0009847", "GO:0016020" ]

[ "spore germination", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PIRSF" ]

[ "PF03323", "PIRSF005690" ]

[ "GerA", "GerBA" ]

[ 15563, 14353 ]

2

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[ "6o59" ]

1

[ "PUB00019610" ]

[ "10762253" ]

[ "Role of ger proteins in nutrient and nonnutrient triggering of spore germination in Bacillus subtilis." ]

[ 2000 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 15502, 14, 47 ]

3

[ "Arabidopsis thaliana" ]

[ 1 ]

1

true

Family

Bacillus/Clostridium Ger spore germination protein

Spore_Ger

8

IPR004996

4,996

DNA helicase/primase complex-associated protein

HSV_HEPA

Family

586

false

Proteins in this family are a component of the helicase/primase complex. The helicase generates single stranded DNA by unwinding the double helix at the replication forks, and the primase synthesizes short RNA primers that the polymerase then elongates [ ]. The function of the proteins, which have no known catalytic ac...

[ "GO:0019079" ]

[ "viral genome replication" ]

[ "biological_process" ]

1

[ "HAMAP", "PFAM" ]

[ "MF_04010", "PF03324" ]

[ "HSV_HEPA", "Herpes_HEPA" ]

[ 506, 578 ]

2

[ "REACTOME", "REACTOME" ]

[ "R-HSA-9609690", "R-HSA-9610379" ]

[ "REACTOME:R-HSA-9609690", "REACTOME:R-HSA-9610379" ]

2

[ "9nda", "9ndq", "9ndz", "9neb" ]

4

[ "PUB00079961", "PUB00079962" ]

[ "23930666", "24747220" ]

[ "The DNA helicase-primase complex as a target for herpes viral infection.", "Herpesviral helicase-primase subunit UL8 is inactivated B-family polymerase." ]

[ 2013, 2014 ]

2

[]

0

null

[ "Homo sapiens", "Orthoherpesviridae" ]

[ 1, 585 ]

2

[ "Homo sapiens" ]

[ 1 ]

1

true

Family

DNA helicase/primase complex-associated protein

HSV_HEPA

1

IPR004998

4,998

Herpesvirus transcription activation factor

Herpes_TAF50

Family

151

false

This is a family of early or early-intermediate transcription factors. This family includes EBV BRLF1 and similar ORF 50 proteins from other herpesviruses.

[ "GO:0006355" ]

[ "regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF03326" ]

[ "Herpes_TAF50" ]

[ 151 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Herpesvirales" ]

[ 2, 149 ]

2

[]

0

true

Family

Herpesvirus transcription activation factor

Herpes_TAF50

6

IPR004999

4,999

Herpesvirus capsid shell protein 1

Herpes_1

Family

424

false

The family includes the triplex capsid protein 1 (TRX1, UL38 or VP19C) from herpesviruses, which is a structural component of the icosahedral capsid. The capsid is composed of pentamers and hexamers of the major capsid protein, which are linked together by heterotrimers called triplexes. These triplexes are formed by a...

[ "GO:0003677", "GO:0019069" ]

[ "DNA binding", "viral capsid assembly" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PFAM" ]

[ "MF_04018", "PF03327" ]

[ "HSV_TRX1", "Herpes_VP19C" ]

[ 344, 424 ]

2

[ "REACTOME", "REACTOME" ]

[ "R-HSA-9609690", "R-HSA-9610379" ]

[ "REACTOME:R-HSA-9609690", "REACTOME:R-HSA-9610379" ]

2

[ "5vku", "5zap", "5zz8", "6b43", "6cgr", "6lgl", "6lgn", "6m6g", "6m6h", "6m6i", "6nhj", "6odm", "6ppb", "6ppd", "6pph", "6q1f", "6w19", "6w2d", "6w2e", "7bqx", "7br7", "7br8", "7bsi", "7bw6", "7et3", "7etj", "7eto", "7fj1", "7fj3", "7liv", "8hex", "8hey"...

45

[ "PUB00003549", "PUB00084216", "PUB00084217", "PUB00084218" ]

[ "10400780", "8918600", "16378995", "16415029" ]

[ "Roles of triplex and scaffolding proteins in herpes simplex virus type 1 capsid formation suggested by structures of recombinant particles.", "The herpes simplex virus procapsid: structure, conformational changes upon maturation, and roles of the triplex proteins VP19c and VP23 in assembly.", "Functional analy...

[ 1999, 1996, 2006, 2006 ]

4

[]

0

null

[ "Herpesvirales", "Homo sapiens", "Salmonella enterica" ]

[ 422, 1, 1 ]

3

[ "Homo sapiens" ]

[ 1 ]

1

true

Family

Herpesvirus capsid shell protein 1

Herpes_1

3

IPR005000

5,000

HpcH/HpaI aldolase/citrate lyase domain

Aldolase/citrate-lyase_domain

Domain

51,578

false

This domain is found in a number of proteins, including 2-keto-3-deoxy-L-rhamnonate aldolase ( ), 5-keto-4-deoxy-D-glucarate aldolase ( ) and citrate lyase subunit beta ( ). This domain has a TIM-barrel fold [ ].

[ "GO:0003824" ]

[ "catalytic activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF03328" ]

[ "HpcH_HpaI" ]

[ 51578 ]

1

[ "EC" ]

[ "4.1.2" ]

[ "EC:4.1.2" ]

1

[ "1dxe", "1dxf", "1izc", "1sgj", "1u5h", "1u5v", "1z6k", "2v5j", "2v5k", "2vws", "2vwt", "3qll", "3qqw", "3qz6", "3r4i", "4b5s", "4b5t", "4b5u", "4b5v", "4b5w", "4b5x", "4l7z", "4l80", "4l9y", "4l9z", "4mf4", "4tv5", "4tv6", "5ugr", "5vxc", "5vxo", "5vxs"...

67

[ "PUB00049940" ]

[ "18754683" ]

[ "Crystal structure and functional assignment of YfaU, a metal ion dependent class II aldolase from Escherichia coli K12." ]

[ 2008 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 1222, 40722, 2, 8709, 923 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 16, 1, 3, 3, 4, 2, 2, 3, 3, 8 ]

10

true

Domain

HpcH/HpaI aldolase/citrate lyase domain

Aldolase/citrate-lyase_domain

1

IPR005001

5,001

RNA-binding protein Hfq

Hfq

Family

12,469

false

This entry represents the RNA-binding pleiotropic regulator Hfq, a small, Sm-like protein of bacteria [ ]. It helps pair regulatory non-coding RNAs with complementary mRNA target regions. It enhances the elongation of poly(A) tails on mRNA [ ]. It appears also to protect RNase E recognition sites (A/U-rich sequences wi...

[ "GO:0003723", "GO:0006355" ]

[ "RNA binding", "regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PFAM", "PANTHER", "NCBIFAM", "CDD" ]

[ "MF_00436", "PF17209", "PTHR34772", "TIGR02383", "cd01716" ]

[ "Hfq", "Hfq", "", "Hfq", "Hfq" ]

[ 11818, 12466, 12248, 12109, 12044 ]

5

[]

0

[ "1hk9", "1kq1", "1kq2", "1u1s", "1u1t", "2qtx", "2y90", "2yht", "2ylb", "2ylc", "3ahu", "3gib", "3hfn", "3hsb", "3inz", "3m4g", "3qhs", "3qo3", "3qsu", "3qui", "3rer", "3res", "3sb2", "3vu3", "4ht8", "4ht9", "4j5y", "4j6w", "4j6x", "4j6y", "4jli", "4jri"...

72

[ "PUB00007236", "PUB00014979", "PUB00016696", "PUB00017770", "PUB00017771", "PUB00103793" ]

[ "12095248", "15009882", "8197116", "15531892", "14561880", "20927372" ]

[ "Structural Modelling of the Sm-like Protein Hfq from Escherichia coli.", "The bacterial Sm-like protein Hfq: a key player in RNA transactions.", "The expression of nifA in Azorhizobium caulinodans requires a gene product homologous to Escherichia coli HF-I, an RNA-binding protein involved in the replication of...

[ 2002, 2004, 1994, 2004, 2003, 2010 ]

6

[]

0

null

[ "Archaea", "Bacteria", "Cecivirus", "Eukaryota", "unclassified sequences" ]

[ 15, 12322, 2, 9, 121 ]

5

[ "Escherichia coli (strain K12)", "Homo sapiens" ]

[ 1, 1 ]

2

true

Family

RNA-binding protein Hfq

Hfq

9

IPR005002

5,002

Phosphomannomutase

PMM

Family

7,600

false

This enzyme ( ) is involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions [ ].

[ "GO:0004615", "GO:0009298" ]

[ "phosphomannomutase activity", "GDP-mannose biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER", "SFLD", "CDD" ]

[ "PF03332", "PTHR10466", "SFLDF00445", "cd02585" ]

[ "PMM", "", "alpha-phosphomannomutase", "HAD_PMM" ]

[ 7519, 6749, 4083, 5506 ]

4

[ "EC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "5.4.2.8", "PWY-5659", "PWY-7456", "PWY-7586", "R-BTA-446205", "R-CEL-446205", "R-DDI-446205", "R-DME-446205", "R-HSA-4043911", "R-HSA-446205", "R-MMU-446205", "R-PFA-446205", "R-SCE-446205", "R-SPO-446205" ]

[ "EC:5.4.2.8", "METACYC:PWY-5659", "METACYC:PWY-7456", "METACYC:PWY-7586", "REACTOME:R-BTA-446205", "REACTOME:R-CEL-446205", "REACTOME:R-DDI-446205", "REACTOME:R-DME-446205", "REACTOME:R-HSA-4043911", "REACTOME:R-HSA-446205", "REACTOME:R-MMU-446205", "REACTOME:R-PFA-446205", "REACTOME:R-SCE-4...

14

[ "2amy", "2fuc", "2fue", "2i54", "2i55", "2q4r", "3f9r", "4bnd", "5ue7", "6cfr", "6cfs", "6cft", "6cfu", "6cfv", "6i5x", "7myv", "7o0c", "7o1b", "7o4g", "7o58", "7o5z", "8b5v" ]

22

[ "PUB00040813" ]

[ "16540464" ]

[ "The X-ray crystal structures of human alpha-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a." ]

[ 2006 ]

1

[ "IPR006379" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Promethearchaeaceae", "Viruses", "metagenomes" ]

[ 1167, 6382, 2, 25, 24 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 2, 1, 19, 11, 1, 3, 12, 1, 1, 3 ]

12

true

Family

Phosphomannomutase

PMM

4

IPR005003

5,003

Bacteriophage lambda, Tail fiber protein, repeat-1

Phage_lambda_Stf-r1

Repeat

452

false

This entry represents repeat 1 of Tail fibre protein from Bacteriophage lambda (Stf or Gp27) and similar proteins from the tailed bacteriophages Caudovirales, such as Long-tail fibre protein gp37 from Bacteriophage T4 (Gp37), and prophages mainly found in Gammaproteobacteria such as Prophage side tail fibre protein hom...

[ "GO:0005198" ]

[ "structural molecule activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF03335" ]

[ "Phage_fiber" ]

[ 452 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[ "2xgf" ]

1

[ "PUB00054644", "PUB00094388", "PUB00099967", "PUB00099968", "PUB00099969" ]

[ "21041684", "29204885", "1439823", "30463036", "8709154" ]

[ "Structure of the bacteriophage T4 long tail fiber receptor-binding tip.", "Bacteriophage T4 long tail fiber domains.", "Bacteriophage lambda PaPa: not the mother of all lambda phages.", "The role of side tail fibers during the infection cycle of phage lambda.", "Stoichiometry and domainal organization of t...

[ 2010, 2018, 1992, 2019, 1996 ]

5

[]

0

null

[ "Bacteria", "Protostomia", "Viruses" ]

[ 334, 2, 116 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Repeat

Bacteriophage lambda, Tail fiber protein, repeat-1

Phage_lambda_Stf-r1

9

IPR005004

5,004

Poxvirus C4/C10

Poxvirus_C4/C10

Family

268

false

This family represents proteins found in Poxvirus, including Protein C10 and Protein C4. Vaccinia virus protein C4 plays a role in the inhibition of host NF-kappa-B activation. It blocks the subunit p65/RELA translocation into the host nucleus [ ].

[]

0

[ "PFAM", "PIRSF" ]

[ "PF03336", "PIRSF003698" ]

[ "Pox_C4_C10", "VAC_C10L" ]

[ 268, 199 ]

2

[]

0

[ "8ag3", "8ag4", "8ag5" ]

3

[ "PUB00099120" ]

[ "22791606" ]

[ "Vaccinia virus protein C4 inhibits NF-κB activation and promotes virus virulence." ]

[ 2012 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Nucleocytoviricota", "viral metagenome" ]

[ 2, 4, 259, 3 ]

4

[]

0

true

Family

Poxvirus C4/C10

Poxvirus_C4/C10

4

IPR005005

5,005

Poxvirus F12L

Poxvirus_F12L

Family

195

false

The vaccinia virus F12L gene encodes a 65kDa protein called Protein OPG056 that is expressed late during infection and is important for plaque formation, EEV production and virulence. The F12L protein is located on intracellular enveloped virus (IEV) particles, but is absent from immature virions, intracellular mature ...

[ "GO:0016032" ]

[ "viral process" ]

[ "biological_process" ]

1

[ "PFAM", "PIRSF" ]

[ "PF03337", "PIRSF015793" ]

[ "Pox_F12L", "VAC_EEV" ]

[ 195, 184 ]

2

[]

0

[]

0

[ "PUB00007237", "PUB00103567", "PUB00103568" ]

[ "11752717", "20195521", "19207726" ]

[ "The vaccinia virus F12L protein is associated with intracellular enveloped virus particles and is required for their egress to the cell surface.", "Vaccinia protein F12 has structural similarity to kinesin light chain and contains a motor binding motif required for virion export.", "An E2-F12 complex is requir...

[ 2002, 2010, 2009 ]

3

[]

0

null

[ "Poxviridae" ]

[ 195 ]

1

[]

0

true

Family

Poxvirus F12L

Poxvirus_F12L

7

IPR005007

5,007

Poxvirus L3/FP4

Poxvirus_L3/FP4

Family

161

false

This is a family of proteins expressed by members of the Poxviridae. Protein L3, also known as Protein OPG097, is required for transcription of early genes [ ].

[]

0

[ "PFAM" ]

[ "PF03339" ]

[ "Pox_L3_FP4" ]

[ 161 ]

1

[]

0

[]

0

[ "PUB00078714" ]

[ "16282472" ]

[ "The conserved poxvirus L3 virion protein is required for transcription of vaccinia virus early genes." ]

[ 2005 ]

1

[]

0

null

[ "Poxviridae" ]

[ 161 ]

1

[]

0

true

Family

Poxvirus L3/FP4

Poxvirus_L3/FP4

2

IPR005008

5,008

Poxvirus rifampicin-resistance

Poxvirus_Rif-R

Family

164

false

This family represents the Poxvirus rifampicin resistance protein (Scaffold protein OPG125), a scaffold protein which forms a transitory spherical honeycomb lattice providing curvature and rigidity to the convex membrane of crescent and immature virions (IV). This association occurs concomitantly with viral membrane fo...

[ "GO:0046677" ]

[ "response to antibiotic" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF03340" ]

[ "Pox_Rif" ]

[ 164 ]

1

[]

0

[ "2ygb", "2ygc", "3sam", "3saq", "6beb", "6bec", "6bed", "6bee", "6bef", "6beg", "6beh", "6bei", "7vfd", "7vfe", "7vff", "7vfg", "7vfh", "8arh", "8f47", "8f65", "9ikc" ]

21

[ "PUB00007238", "PUB00103569", "PUB00103570" ]

[ "8609479", "19570860", "35361762" ]

[ "An entomopoxvirus homologue of the vaccinia virus D13L-encoded 'rifampicin resistance' protein.", "Assembly and disassembly of the capsid-like external scaffold of immature virions during vaccinia virus morphogenesis.", "Assembly mechanism of the pleomorphic immature poxvirus scaffold." ]

[ 1996, 2009, 2022 ]

3

[]

0

null

[ "Macrosiphum euphorbiae", "Poxviridae" ]

[ 1, 163 ]

2

[]

0

true

Family

Poxvirus rifampicin-resistance

Poxvirus_Rif-R

8

IPR005009

5,009

Poxvirus mRNA capping enzyme, small subunit

Poxvirus_mRNA-cap_ssu

Family

132

false

This protein family includes mRNA-capping enzyme regulatory subunit OPG124, also known as mRNA-capping enzyme small subunit, from Vaccinia virus. This protein stabilizes the catalytic subunit and enhances its methyltransferase activity through an allosteric mechanism [ , ]. Vaccinia virus, the prototypic poxvirus, poss...

[ "GO:0004482", "GO:0006370" ]

[ "mRNA 5'-cap (guanine-N7-)-methyltransferase activity", "7-methylguanosine mRNA capping" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF03341" ]

[ "Pox_mRNA-cap" ]

[ 132 ]

1

[]

0

[ "2vdw", "4ckb", "4ckc", "4cke", "6rfl", "6rie", "8jed", "8p0j", "8p0n", "8rqk", "8y2y", "8y2z", "8ze4", "9fq6" ]

14

[ "PUB00103571", "PUB00103572" ]

[ "2552660", "18455214" ]

[ "Vaccinia virus gene D12L encodes the small subunit of the viral mRNA capping enzyme.", "Vaccinia virus early gene transcription termination factors VTF and Rap94 interact with the U9 termination motif in the nascent RNA in a transcription ternary complex." ]

[ 1989, 2008 ]

2

[]

0

null

[ "Poxviridae" ]

[ 132 ]

1

[]

0

true

Family

Poxvirus mRNA capping enzyme, small subunit

Poxvirus_mRNA-cap_ssu

2

IPR005010

5,010

Rhabdovirus M1 matrix protein

Rhabdo_M1

Family

87

false

This is a family of phosphoproteins of unknown function expressed by Rhadovirus.

[]

0

[ "PFAM" ]

[ "PF03342" ]

[ "Rhabdo_M1" ]

[ 87 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Novirhabdovirus" ]

[ 87 ]

1

[]

0

true

Family

Rhabdovirus M1 matrix protein

Rhabdo_M1

9

IPR005011

5,011

SNU66/SART1 family

SNU66/SART1

Family

4,790

false

This entry represents U4/U6.U5 tri-snRNP-associated proteins, including SART1 from animals, Snu66 from yeasts and DOT2 from Arabidopsis.

[ "GO:0000398" ]

[ "mRNA splicing, via spliceosome" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF03343", "PTHR14152" ]

[ "SART-1", "" ]

[ 4695, 4723 ]

2

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-72163", "R-MMU-72163", "R-RNO-72163" ]

[ "REACTOME:R-HSA-72163", "REACTOME:R-MMU-72163", "REACTOME:R-RNO-72163" ]

3

[ "5nrl", "5o9z", "5zwm", "5zwo", "6ahd", "6qw6", "6qx9", "8h6e", "8h6j", "8h6k", "8h6l", "8q7n", "8qo9", "8qoz", "8qp8", "8qp9", "8qpa", "8qpb", "8qpe", "8qpk", "8qxd", "8qzs", "8r08", "8r09", "8r0a", "8r0b", "8rm5", "8y6o" ]

28

[ "PUB00033684", "PUB00062925", "PUB00072439", "PUB00074675", "PUB00074676" ]

[ "15620657", "10377396", "18643975", "11350945", "19000164" ]

[ "Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast.", "Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins.", "Vein patterning screens and the defectively organized tributarie...

[ 2004, 1999, 2008, 2001, 2009 ]

5

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 4788, 2 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 2, 4, 4, 2, 1, 3, 4, 1, 1, 3 ]

12

true

Family

SNU66/SART1 family

SNU66/SART1

9

IPR005013

5,013

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48kDa subunit

DDOST_48_kDa_subunit

Family

6,004

false

Members of this family are involved in asparagine-linked protein glycosylation. In particular, dolichyl-diphosphooligosaccharide-protein glycosyltransferase (DDOST), also known as oligosaccharyltransferase ( ), transfers the high-mannose sugar GlcNAc(2)-Man(9)-Glc(3) from a dolichol-linked donor to an asparagine accept...

[ "GO:0006487", "GO:0005789" ]

[ "protein N-linked glycosylation", "endoplasmic reticulum membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PANTHER" ]

[ "PTHR10830" ]

[ "" ]

[ 6004 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-6798695", "R-DDI-6798695", "R-DME-6798695", "R-DME-9768727", "R-DRE-6798695", "R-DRE-9768727", "R-HSA-1799339", "R-HSA-446203", "R-HSA-6798695", "R-HSA-879415", "R-HSA-9694548", "R-HSA-9768727", "R-MMU-6798695", "R-MMU-9768727", "R-RNO-6798695", "R-RNO-9768727", "R-SCE-6798695...

[ "REACTOME:R-CEL-6798695", "REACTOME:R-DDI-6798695", "REACTOME:R-DME-6798695", "REACTOME:R-DME-9768727", "REACTOME:R-DRE-6798695", "REACTOME:R-DRE-9768727", "REACTOME:R-HSA-1799339", "REACTOME:R-HSA-446203", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-879415", "REACTOME:R-HSA-9694548", "REACTOME:...

19

[ "6c26", "6ezn", "6s7o", "6s7t", "7oci", "8agb", "8agc", "8age", "8b6l", "8pn9" ]

10

[ "PUB00054186", "PUB00054187", "PUB00054188", "PUB00054189", "PUB00075630" ]

[ "8175708", "1724755", "1600939", "8428586", "936767" ]

[ "The Saccharomyces cerevisiae oligosaccharyltransferase is a protein complex composed of Wbp1p, Swp1p, and four additional polypeptides.", "An essential 45 kDa yeast transmembrane protein reacts with anti-nuclear pore antibodies: purification of the protein, immunolocalization and cloning of the gene.", "The ye...

[ 1994, 1991, 1992, 1993, 1976 ]

5

[]

0

null

[ "Eukaryota" ]

[ 6004 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 2, 1, 3, 4, 1, 2, 6, 1, 1, 13 ]

12

true

Family

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48kDa subunit

DDOST_48_kDa_subunit

9

IPR005015

5,015

Thermostable direct haemolysin, vibrio

Thermostable_hemolysn_vibrio

Family

149

false

Thermostable direct haemolysin (TDH) is considered an important virulence factor in Vibrio parahaemolyticus gastroenteritis and is a dimer composed of two identical subunit molecules of approximately 21kDa. The tetrameric form contains a central pore permitting entry and exit of water molecules. A number of biological ...

[ "GO:0019836", "GO:0005576" ]

[ "symbiont-mediated hemolysis of host erythrocyte", "extracellular region" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF03347" ]

[ "TDH" ]

[ 149 ]

1

[]

0

[ "3a57", "4wx3", "4wx5" ]

3

[ "PUB00007242" ]

[ "11267763" ]

[ "Monodansylcadaverine inhibits cytotoxicity of Vibrio parahaemolyticus thermostable direct hemolysin on cultured rat embryonic fibroblast cells." ]

[ 2001 ]

1

[]

0

null

[ "Gammaproteobacteria" ]

[ 149 ]

1

[]

0

true

Family

Thermostable direct haemolysin, vibrio

Thermostable_hemolysn_vibrio

2

IPR005016

5,016

Serine incorporator/TMS membrane protein

TDE1/TMS

Family

13,083

false

The serine incorporator/TMS membrane protein (TDE1/TMS) family include SERINC1-5 from mammals and its homologues membrane protein Tms1 from yeasts. Members in this family contain eleven transmembrane helices. SERINC1-5 function in incorporating serine into membranes and facilitating the synthesis of two serine-derived ...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF03348", "PTHR10383" ]

[ "Serinc", "" ]

[ 13035, 12804 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-977347", "R-DDI-977347", "R-DRE-977347", "R-HSA-977347", "R-MMU-977347", "R-RNO-977347", "R-SCE-977347", "R-SPO-977347" ]

[ "REACTOME:R-BTA-977347", "REACTOME:R-DDI-977347", "REACTOME:R-DRE-977347", "REACTOME:R-HSA-977347", "REACTOME:R-MMU-977347", "REACTOME:R-RNO-977347", "REACTOME:R-SCE-977347", "REACTOME:R-SPO-977347" ]

8

[ "6sp2", "7ru6", "7rug" ]

3

[ "PUB00033686", "PUB00070879", "PUB00156058", "PUB00156059", "PUB00156060", "PUB00156061" ]

[ "16120614", "16547497", "26416733", "26416734", "37474505", "39271159" ]

[ "Serinc, an activity-regulated protein family, incorporates serine into membrane lipid synthesis.", "Human TDE1, a TDE1/TMS family member, inhibits apoptosis in vitro and stimulates in vivo tumorigenesis.", "SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef.", "HIV-1 Nef promotes infe...

[ 2005, 2006, 2015, 2015, 2023, 2024 ]

6

[]

0

null

[ "Eukaryota" ]

[ 13083 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 32, 3, 8, 8, 15, 19, 1, 13, 23, 1, 1, 58 ]

12

true

Family

Serine incorporator/TMS membrane protein

TDE1/TMS

4

IPR005017

5,017

Outer membrane protein transport protein (OMPP1/FadL/TodX)

OMPP1/FadL/TodX

Family

17,135

false

This family includes TodX from Pseudomonas putida (strain F1/ATCC 700007) [ , ] and TbuX from Burkholderia pickettii (Ralstonia pickettii) (Pseudomonas pickettii) PKO1 [ ]. These are membrane proteins of uncertain function that are involved in toluene catabolism. Related proteins involved in the degradation of similar ...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF03349", "PTHR35093" ]

[ "Toluene_X", "" ]

[ 15437, 16667 ]

2

[]

0

[ "1t16", "1t1l", "2r4l", "2r4n", "2r4o", "2r4p", "2r88", "2r89", "2r8a", "3bry", "3brz", "3bs0", "3dwn", "3dwo", "3pf1", "3pgr", "3pgs", "3pgu", "6z34", "6z37", "6z38", "9hiv", "9hj3" ]

23

[ "PUB00020445", "PUB00020446", "PUB00020447" ]

[ "7535376", "10671442", "9150211" ]

[ "Identification of a membrane protein and a truncated LysR-type regulator associated with the toluene degradation pathway in Pseudomonas putida F1.", "Characterization and role of tbuX in utilization of toluene by Ralstonia pickettii PKO1.", "p-Cymene catabolic pathway in Pseudomonas putida F1: cloning and char...

[ 1995, 2000, 1997 ]

3

[]

0

null

[ "Bacteria", "Candidatus Methanoperedens nitratireducens", "Eukaryota", "unclassified sequences" ]

[ 16918, 1, 14, 202 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Outer membrane protein transport protein (OMPP1/FadL/TodX)

OMPP1/FadL/TodX

8

IPR005018

5,018

DOMON domain

DOMON_domain

Domain

23,188

false

The DOMON domain is an 110-125 residue long domain which has been identified in the physiologically important enzyme dopamine beta-monooxygenase and in several other secreted and transmembrane proteins from both plants and animals. It has been named after DOpamine beta-MOnooxygenase N-terminal domain. The DOMON domain ...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF03351", "PS50836", "SM00664" ]

[ "DOMON", "DOMON", "DoH" ]

[ 14024, 21096, 14983 ]

3

[ "GP", "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "GenProp1606", "PDOC50836", "R-DME-209905", "R-HSA-209905", "R-MMU-209905", "R-RNO-209905" ]

[ "GP:GenProp1606", "PROSITEDOC:PDOC50836", "REACTOME:R-DME-209905", "REACTOME:R-HSA-209905", "REACTOME:R-MMU-209905", "REACTOME:R-RNO-209905" ]

6

[ "1d7b", "1d7c", "1d7d", "1pl3", "4zel", "6jt6" ]

6

[ "PUB00007243", "PUB00044228" ]

[ "11551777", "17878204" ]

[ "DOMON: an ancient extracellular domain in dopamine beta-monooxygenase and other proteins.", "The DOMON domains are involved in heme and sugar recognition." ]

[ 2001, 2007 ]

2

[]

[ "IPR015920", "IPR045265", "IPR045266" ]

0

3

0

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Siphoviridae sp. ctsYb1", "ecological metagenomes" ]

[ 252, 22893, 31, 1, 11 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 49, 19, 23, 20, 7, 7, 1, 46, 16, 64 ]

10

true

Domain

DOMON domain

DOMON_domain

7

IPR005019

5,019

Methyladenine glycosylase

Adenine_glyco

Family

26,145

false

This family of methyladenine glycosylases includes DNA-3-methyladenine glycosylase I ( ) which acts as a base excision repair enzyme by severing the glycosylic bond of numerous damaged bases. The enzyme is constitutively expressed and is specific for the alkylated 3-methyladenine DNA [ ].

[ "GO:0008725", "GO:0006284" ]

[ "DNA-3-methyladenine glycosylase activity", "base-excision repair" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF03352" ]

[ "Adenine_glyco" ]

[ 26145 ]

1

[]

0

[ "1lmz", "1nku", "1p7m", "2jg6", "2ofi", "2ofk", "4ai4", "4ai5", "4aia" ]

9

[ "PUB00017507" ]

[ "3536912" ]

[ "Purification and structure of 3-methyladenine-DNA glycosylase I of Escherichia coli." ]

[ 1986 ]

1

[]

[ "IPR004597" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 104, 22135, 3620, 286 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 26, 1, 17, 41 ]

4

true

Family

Methyladenine glycosylase

Adenine_glyco

5

IPR005020

5,020

Protein LIN-8

LIN-8

Family

213

false

This entry represents a family of proteins found in Caenorhabditis called LIN-8, previously known as DUF278. LIN-8 is a nuclear protein, present at the sites of transcriptional repressor complexes, which interacts with LIN-35 Rb. Lin35 Rb is a product of the class B synMuv gene lin-35 which silences genes required for ...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF03353", "PTHR32020" ]

[ "Lin-8", "" ]

[ 207, 176 ]

2

[]

0

[]

0

[ "PUB00083139" ]

[ "16020796" ]

[ "lin-8, which antagonizes Caenorhabditis elegans Ras-mediated vulval induction, encodes a novel nuclear protein that interacts with the LIN-35 Rb protein." ]

[ 2005 ]

1

[]

0

null

[ "Caenorhabditis" ]

[ 213 ]

1

[ "Caenorhabditis elegans" ]

[ 22 ]

1

true

Family

Protein LIN-8

LIN-8

5

IPR005021

5,021

Terminase large subunit-like

Terminase_largesu-like

Family

11,309

false

Terminase large subunit (TerL) from bacteriophages and evolutionarily related viruses, is an important component of the DNA packing machinery and comprises an ATPase domain, which powers DNA translocation and a nuclease domain that cuts concatemeric DNA [ , , ]. TerL forms pentamers in which the ATPase domains form a r...

[]

0

[ "PANTHER" ]

[ "PTHR41287" ]

[ "" ]

[ 11309 ]

1

[ "EC", "GP", "METACYC" ]

[ "3.6.4.-", "GenProp0208", "PWY-7250" ]

[ "EC:3.6.4.-", "GP:GenProp0208", "METACYC:PWY-7250" ]

3

[ "6z6d" ]

1

[ "PUB00082566", "PUB00098421", "PUB00098422" ]

[ "24027307", "28100693", "26150523" ]

[ "Structure, adsorption to host, and infection mechanism of virulent lactococcal phage p2.", "Viral genome packaging terminase cleaves DNA using the canonical RuvC-like two-metal catalysis mechanism.", "Structure and mechanism of the ATPase that powers viral genome packaging." ]

[ 2013, 2017, 2015 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Halobaculum halobium", "Viruses", "unclassified sequences" ]

[ 9424, 17, 4, 1642, 222 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Terminase large subunit-like

Terminase_largesu-like

9

IPR005022

5,022

Viral trans-activator protein

Pox_TAP

Family

180

false

This family of proteins function as a trans-activator of viral late genes.

[ "GO:0006355" ]

[ "regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF03355" ]

[ "Pox_TAP" ]

[ 180 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Poxviridae" ]

[ 180 ]

1

[]

0

true

Family

Viral trans-activator protein

Pox_TAP

2

IPR005023

5,023

Viral late protein H2

Pox_LP_H2

Family

187

false

This entry represents the late protein H2 found in Vaccinia and other poxviruses. This protein is a highly conserved viral membrane protein found in all sequenced poxviruses, containing an N-terminal transmembrane domain and four conserved cysteines thought to be involved in the formation of intramolecular disulphide b...

[]

0

[ "PFAM" ]

[ "PF03356" ]

[ "Pox_LP_H2" ]

[ 187 ]

1

[]

0

[ "8ini" ]

1

[ "PUB00034708", "PUB00034709" ]

[ "15795260", "16339313" ]

[ "Vaccinia virus H2 protein is an essential component of a complex involved in virus entry and cell-cell fusion.", "Poxvirus multiprotein entry-fusion complex." ]

[ 2005, 2005 ]

2

[]

0

null

[ "Poxviridae" ]

[ 187 ]

1

[]

0

true

Family

Viral late protein H2

Pox_LP_H2

8

IPR005024

5,024

Snf7 family

Snf7_fam

Family

40,285

false

Snf7 family members are small coil-coiled proteins that share protein sequence similarity with budding yeast Snf7, which is part of the ESCRT-III complex that is required for endosome-mediated trafficking via multivesicular body (MVB) formation and sorting [ ]. Proteins in this entry also includes human CHMPs (charged ...

[ "GO:0007034" ]

[ "vacuolar transport" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER", "PANTHER" ]

[ "PF03357", "PTHR10476", "PTHR22761" ]

[ "Snf7", "", "" ]

[ 39332, 18661, 20211 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1632852", "R-BTA-5620971", "R-BTA-917729", "R-BTA-9668328", "R-DDI-1632852", "R-DDI-917729", "R-DDI-9668328", "R-DME-1632852", "R-DME-917729", "R-DME-9668328", "R-DRE-1632852", "R-DRE-917729", "R-DRE-9668328", "R-GGA-1632852", "R-GGA-5620971", "R-GGA-917729", "R-GGA-9668328", ...

[ "REACTOME:R-BTA-1632852", "REACTOME:R-BTA-5620971", "REACTOME:R-BTA-917729", "REACTOME:R-BTA-9668328", "REACTOME:R-DDI-1632852", "REACTOME:R-DDI-917729", "REACTOME:R-DDI-9668328", "REACTOME:R-DME-1632852", "REACTOME:R-DME-917729", "REACTOME:R-DME-9668328", "REACTOME:R-DRE-1632852", "REACTOME:R...

46

[ "2gd5", "2luh", "2lxm", "3frt", "3frv", "3jc1", "3um3", "4abm", "4txr", "5fd7", "5fd9", "5j45", "5t8l", "5t8n", "5vo5", "6e8g", "6tz4", "6tz5", "6tz9", "6zh3", "7zcg", "7zch", "8v2q", "8v2r", "8v2s", "8wb6", "8wb7", "9fn1", "9ftl", "9ftm", "9jsd" ]

31

[ "PUB00071227", "PUB00083231" ]

[ "15086794", "18987308" ]

[ "Protein-protein interactions of ESCRT complexes in the yeast Saccharomyces cerevisiae.", "A unique cell division machinery in the Archaea." ]

[ 2004, 2008 ]

2

[]

0

null

[ "Archaea", "Eukaryota", "Megaviridae environmental sample", "unclassified sequences" ]

[ 89, 40159, 1, 36 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 57, 9, 28, 12, 41, 23, 8, 45, 41, 7, 7, 108 ]

12

true

Family

Snf7 family

Snf7_fam

6

IPR005025

5,025

NADPH-dependent FMN reductase-like domain

FMN_Rdtase-like_dom

Domain

97,590

false

This domain in found in several flavoproteins such as FMN-dependent NADPH-azoreductase, which catalyses the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines [ ], and NAD(P)H:quinone oxidoreductase, which reduces quinones to the hydroquinone state to prevent interaction of the semiqui...

[ "GO:0016491" ]

[ "oxidoreductase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF03358" ]

[ "FMN_red" ]

[ 97590 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "1.6.5.2", "PWY-7731", "PWY-7999" ]

[ "EC:1.6.5.2", "METACYC:PWY-7731", "METACYC:PWY-7999" ]

3

[ "1nni", "1rli", "1rtt", "1sqs", "1t0i", "1x77", "1zwk", "1zwl", "2a5l", "2fzv", "2gsw", "2oys", "2q62", "2r96", "2r97", "2rg1", "2zki", "3b6i", "3b6j", "3b6k", "3b6m", "3d7n", "3fvw", "3gfq", "3gfr", "3gfs", "3k1y", "3k20", "3s2y", "3svl", "3u7r", "3zho"...

65

[ "PUB00043027", "PUB00068233", "PUB00068234", "PUB00068235", "PUB00068236" ]

[ "9694845", "16752898", "10606758", "11591665", "14766567" ]

[ "Biochemical characterization of WrbA, founding member of a new family of multimeric flavodoxin-like proteins.", "Characterization of a thermostable NADPH:FMN oxidoreductase from the mesophilic bacterium Bacillus subtilis.", "Cloning and heterologous expression of NAD(P)H:quinone reductase of Arabidopsis thalia...

[ 1998, 2006, 1999, 2001, 2004 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 2600, 83911, 10211, 7, 861 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 20, 4, 13, 3, 2, 31 ]

6

true

Domain

NADPH-dependent FMN reductase-like domain

FMN_Rdtase-like_dom

9

IPR005026

5,026

SAPAP family

SAPAP

Family

10,081

false

This entry represents the SAPAP family, whose members include mars from fruit flies and disks large-associated proteins from vertebrates. Mars binds to microtubules and protein phosphatase 1. It is involved in cell signalling, mitotic spindle organisation and regulation of mitotic cell cycle [ , ]. It is essential for ...

[ "GO:0023052" ]

[ "signaling" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF03359", "PTHR12353" ]

[ "GKAP", "" ]

[ 8957, 10015 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-6794361", "R-HSA-6794361", "R-HSA-9013508", "R-MMU-6794361", "R-RNO-6794361" ]

[ "REACTOME:R-DME-6794361", "REACTOME:R-HSA-6794361", "REACTOME:R-HSA-9013508", "REACTOME:R-MMU-6794361", "REACTOME:R-RNO-6794361" ]

5

[ "4r0y", "5izu", "8x9p", "9dhz" ]

4

[ "PUB00019615", "PUB00073093", "PUB00073095", "PUB00073096" ]

[ "9024696", "9286858", "23593258", "17007873" ]

[ "GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules.", "DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95.", "The Drosophila microtubule-associated protein mars stabilizes mi...

[ 1997, 1997, 2013, 2006 ]

4

[]

0

null

[ "Eukaryota" ]

[ 10081 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 90, 4, 32, 32, 36 ]

6

true

Family

SAPAP family

SAPAP

7

IPR005028

5,028

Herpesvirus intermediate/early protein 2/3, DNA-binding domain

Herpes_IE2_3

Domain

287

false

This domain is found C-terminal in the Herpes virus 6A intermediate/early protein 2 (IE2), Immediate-early protein 3 (IE3) and related proteins from Herpesvirales, including protein UL117. The C-terminal region of HHV-6A IE2 is involved in dimerisation, DNA binding, and transcription factor binding. This domain forms a...

[ "GO:0006355" ]

[ "regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF03361" ]

[ "Herpes_IE2_3" ]

[ 287 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-9609690", "R-HSA-9610379" ]

[ "REACTOME:R-HSA-9609690", "REACTOME:R-HSA-9610379" ]

2

[ "5wx8" ]

1

[ "PUB00161263", "PUB00161604", "PUB00161605", "PUB00161606" ]

[ "28794035", "20333247", "16884756", "17005699" ]

[ "Crystal Structure of the DNA-Binding Domain of Human Herpesvirus 6A Immediate Early Protein 2.", "Human cytomegalovirus protein pUL117 targets the mini-chromosome maintenance complex and suppresses cellular DNA synthesis.", "Mapping of human herpesvirus 6 immediate-early 2 protein transactivation domains.", ...

[ 2017, 2010, 2006, 2006 ]

4

[]

0

null

[ "Betaherpesvirinae", "Homo sapiens" ]

[ 285, 2 ]

2

[ "Homo sapiens" ]

[ 2 ]

1

true

Domain

Herpesvirus intermediate/early protein 2/3, DNA-binding domain

Herpes_IE2_3

4

IPR005029

5,029

Herpesvirus UL47

Herpes_UL47

Family

395

false

The herpes simplex virus type 1 gene UL47 encodes the tegument proteins referred to collectively as VP13/14, which are believed to be differentially modified forms of the same protein. These proteins have been show to target to the nucleus. The function of this family is unknown but it contains a number of Herpesvirida...

[ "GO:0006355" ]

[ "regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF03362" ]

[ "Herpes_UL47" ]

[ 395 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Alphaherpesvirinae" ]

[ 395 ]

1

[]

0

true

Family

Herpesvirus UL47

Herpes_UL47

1

IPR005030

5,030

Herpesvirus leader protein

Herpes_LP

Domain

37

false

This entry contains Epstein-Barr virus EBNA-LP protein. It is a protein involved in latency whose function is not fully understood. The protein contains three domains, each of which contains conserved serine residues within conserved regions (CR1 to CR3). These regions are essential for the EBNA2 cooperativity function...

[]

0

[ "PFAM" ]

[ "PF03363" ]

[ "Herpes_LP" ]

[ 37 ]

1

[]

0

[ "5x8n" ]

1

[ "PUB00007244" ]

[ "11024123" ]

[ "Conserved regions in the Epstein-Barr virus leader protein define distinct domains required for nuclear localization and transcriptional cooperation with EBNA2." ]

[ 2000 ]

1

[]

0

null

[ "Lymphocryptovirus" ]

[ 37 ]

1

[]

0

true

Domain

Herpesvirus leader protein

Herpes_LP

2

IPR005031

5,031

Coenzyme Q-binding protein COQ10, START domain

COQ10_START

Domain

31,080

false

This entry represents the START domain found in polyketide cylcases/dehydrases such as TcmN [ ] and in coenzyme Q-binding protein COQ10 [ ]. COQ10 is required for the function of coenzyme Q in the respiratory chain and has a steroidogenic acute regulatory protein-related lipid transfer (START) domain, known to bind spe...

[]

0

[ "PFAM" ]

[ "PF03364" ]

[ "Polyketide_cyc" ]

[ 31080 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-611105", "R-DME-9864848", "R-DRE-611105", "R-DRE-9864848", "R-HSA-611105", "R-HSA-9864848", "R-MMU-611105", "R-MMU-9864848", "R-RNO-611105", "R-RNO-9864848" ]

[ "REACTOME:R-DME-611105", "REACTOME:R-DME-9864848", "REACTOME:R-DRE-611105", "REACTOME:R-DRE-9864848", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-9864848", "REACTOME:R-MMU-611105", "REACTOME:R-MMU-9864848", "REACTOME:R-RNO-611105", "REACTOME:R-RNO-9864848" ]

10

[ "1t17", "2d4r", "2kcz", "2kf2", "2rer", "2res", "2rez", "3ggn", "3tl1", "3tvq", "3tvr", "4xrt", "5z8o" ]

13

[ "PUB00007207", "PUB00075380", "PUB00075381", "PUB00075382" ]

[ "11276083", "19120452", "23270816", "1548230" ]

[ "Adaptations of the helix-grip fold for ligand binding and catalysis in the START domain superfamily.", "Coq10, a mitochondrial coenzyme Q binding protein, is required for proper respiration in Schizosaccharomyces pombe.", "A conserved START domain coenzyme Q-binding polypeptide is required for efficient Q bios...

[ 2001, 2009, 2013, 1992 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Escherichia phage vB_EcoM-613R3", "Eukaryota", "unclassified sequences" ]

[ 350, 22150, 1, 8376, 203 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 33, 1, 3, 2, 1, 6, 7, 1, 14, 9, 1, 1, 27 ]

13

true

Domain

Coenzyme Q-binding protein COQ10, START domain

COQ10_START

4

IPR005033

5,033

YEATS

Family

9,033

false

This family is named after YEATS (Yaf9, ENL, AF9, Taf14, and Sas5), an evolutionarily conserved module present in 4 proteins (ENL, AF9, GAS41, and YEATS2) in humans and 3 proteins (Sas5, Taf14, and Yaf9) in yeast. These proteins are found in major chromatin-remodeling and histone acetyl-transferase (HAT) complexes and ...

[ "GO:0006355" ]

[ "regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "PANTHER", "PANTHER" ]

[ "PTHR23195", "PTHR47573" ]

[ "", "" ]

[ 3821, 5212 ]

2

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "PDOC51037", "R-HSA-3214847", "R-HSA-8866907", "R-HSA-9772755", "R-MMU-8866907", "R-MMU-9772755" ]

[ "PROSITEDOC:PDOC51037", "REACTOME:R-HSA-3214847", "REACTOME:R-HSA-8866907", "REACTOME:R-HSA-9772755", "REACTOME:R-MMU-8866907", "REACTOME:R-MMU-9772755" ]

6

[ "2l7e", "3fk3", "3qrl", "3rls", "5d7e", "5iok", "5iql", "5r68", "5r69", "5sva", "5vna", "5vnb", "5wyi", "5xnv", "5xtz", "5y8v", "6axj", "6lsd", "6min", "6mio", "6mip", "6miq", "7eie", "7eif", "7f4a", "7f5m", "7jfy", "8dkb", "8i60", "8ij0", "8jg4", "8x15"...

34

[ "PUB00091361", "PUB00097418" ]

[ "27545619", "26341557" ]

[ "Structural Insights into Histone Crotonyl-Lysine Recognition by the AF9 YEATS Domain.", "Association of Taf14 with acetylated histone H3 directs gene transcription and the DNA damage response." ]

[ 2016, 2015 ]

2

[]

[ "IPR016665" ]

0

1

0

[ "Bacteria", "Cotesia sesamiae Mombasa bracovirus", "Eukaryota" ]

[ 9, 1, 9023 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 8, 2, 6, 4, 6, 6, 2, 3, 7, 3, 2, 3 ]

12

true

Family

YEATS

8

IPR005034

5,034

Dicer, dimerisation domain

Dicer_dimerisation

Domain

9,636

false

This entry represents the dimerisation domain in Dicer. It is essential for the activity of Dicer [ , ]. It is a divergent double-stranded RNA-binding domain [ ]. The N-terminal α helix of this domain is in a different orientation to that found in canonical dsRNA-binding domains. This results in a change of charge dist...

[ "GO:0016891" ]

[ "RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism" ]

[ "molecular_function" ]

1

[ "PFAM", "PROFILE" ]

[ "PF03368", "PS51327" ]

[ "Dicer_dimer", "DICER_DSRBF" ]

[ 9553, 9143 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.26.-", "R-CEL-203927", "R-CEL-426486", "R-DME-203927", "R-DME-426486", "R-HSA-203927", "R-HSA-426486", "R-HSA-9708296", "R-HSA-9820841", "R-HSA-9824594", "R-MMU-203927", "R-MMU-426486", "R-XTR-203927", "R-XTR-426486" ]

[ "EC:3.1.26.-", "REACTOME:R-CEL-203927", "REACTOME:R-CEL-426486", "REACTOME:R-DME-203927", "REACTOME:R-DME-426486", "REACTOME:R-HSA-203927", "REACTOME:R-HSA-426486", "REACTOME:R-HSA-9708296", "REACTOME:R-HSA-9820841", "REACTOME:R-HSA-9824594", "REACTOME:R-MMU-203927", "REACTOME:R-MMU-426486", ...

14

[ "2kou", "5zak", "5zal", "5zam", "6bu9", "6bua", "7eld", "7ele", "7v6b", "7v6c", "7w0a", "7w0b", "7w0c", "7w0d", "7w0e", "7w0f", "7xw2", "7xw3", "7yym", "7yyn", "7yz4", "7zpi", "7zpj", "7zpk", "8dfv", "8dg5", "8dg7", "8dga", "8dgi", "8dgj", "8hf0", "8hf1"...

40

[ "PUB00043692", "PUB00043694", "PUB00047363", "PUB00066744", "PUB00067933", "PUB00077148", "PUB00096053" ]

[ "16954143", "17666393", "17920623", "20106953", "16424907", "23063121", "15973356" ]

[ "DUF283 domain of Dicer proteins has a double-stranded RNA-binding fold.", "Functional anatomy of the Drosophila microRNA-generating enzyme.", "Homodimeric structure and double-stranded RNA cleavage activity of the C-terminal RNase III domain of human dicer.", "Structure of the Arabidopsis thaliana DCL4 DUF28...

[ 2006, 2007, 2007, 2010, 2006, 2012, 2005 ]

7

[]

0

null

[ "Bacteria", "Eukaryota", "Orthocoronavirinae" ]

[ 14, 9615, 7 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 21, 1, 5, 21, 8, 4, 2, 14, 5, 1, 119 ]

11

true

Domain

Dicer, dimerisation domain

Dicer_dimerisation

6