Datasets:

MagistraHealth
/

glp1-aggregate-rates

effect stringlengths 6 23	effectName stringlengths 6 37	severity stringclasses 3 values	clinicalPooledRatePct float64 0.1 20.4 ⌀	clinicalCiLowPct float64 0 6 ⌀	clinicalCiHighPct float64 1 51 ⌀	clinicalStatedRates int64 0 232	clinicalDistinctSources int64 0 75	clinicalSourceDiversity stringclasses 3 values	clinicalRateKind stringclasses 2 values	clinicalIntervalBasis stringclasses 1 value	clinicalPhase1Sources int64 0 7	clinicalPhase2Sources int64 0 2	clinicalPhase3Sources int64 0 61	clinicalPhase4Sources int64 0 3	communityReportingFrequencyPct float64 0 35.7	communityMentions int64 0 15	communityTotalReports int64 42 42
nausea	Nausea	mild	20.4	6	51	232	75	very_high	incidence	sampling_plus_between_study	7	2	61	3	33.3	14	42
diarrhea	Diarrhoea	mild	14.8	5	36	221	66	very_high	incidence	sampling_plus_between_study	6	1	57	2	28.6	12	42
constipation	Constipation	mild	11.6	3	38	209	59	very_high	incidence	sampling_plus_between_study	6	1	49	2	21.4	9	42
reduced_appetite	Reduced appetite	mild	8.6	2	30	205	58	very_high	incidence	sampling_plus_between_study	6	1	48	2	31	13	42
headache	Headache	mild	8.5	3	20	184	51	very_high	incidence	sampling_plus_between_study	6	1	42	2	9.5	4	42
pancreatitis	Pancreatitis (rare)	severe	0.1	0	1	13	4	moderate	mixed_incidence_and_serious_ae	sampling_plus_between_study	0	0	4	0	0	0	42
fatigue	Fatigue / Low energy	mild	6.5	2	18	104	30	very_high	incidence	sampling_plus_between_study	2	1	25	2	14.3	6	42
vomiting	Vomiting	moderate	10.4	3	27	222	67	very_high	incidence	sampling_plus_between_study	7	1	56	2	35.7	15	42
abdominal_pain	Abdominal pain	moderate	5.8	2	18	162	37	very_high	incidence	sampling_plus_between_study	6	1	29	1	19	8	42
acid_reflux	Acid reflux (GERD)	mild	5.2	3	10	80	26	very_high	incidence	sampling_plus_between_study	1	1	23	1	19	8	42
gallstones	Gallstones (cholelithiasis)	severe	1.7	1	4	33	12	high	mixed_incidence_and_serious_ae	sampling_plus_between_study	0	0	11	0	9.5	4	42
hair_loss	Hair loss (thinning)	mild	5	2	11	22	11	high	incidence	sampling_plus_between_study	0	0	9	1	2.4	1	42
injection_site_reaction	Injection site reaction	mild	4.6	1	16	16	7	moderate	incidence	sampling_plus_between_study	0	0	7	0	28.6	12	42
dizziness	Dizziness	mild	6.8	3	14	129	36	very_high	incidence	sampling_plus_between_study	4	1	30	1	7.1	3	42
emotional_blunting	Emotional blunting / Reduced pleasure	moderate	null	null	null	0	0	null	null	null	0	0	0	0	2.4	1	42

GLP-1 Side-Effect Pooled Rates (Magistra aggregate table)

A per-effect summary of how often 15 side effects are reported for GLP-1 medications: a pooled clinical rate with its 95% interval, the number of rates and distinct sources behind it, and, separately, how often each effect is mentioned in a screened set of community reports. Built by Magistra from its curated corpus of clinical-trial registry results, papers and regulatory reports. Snapshot as of 2026-10-04 (version 1.5).

Data, not medical advice. Reporting frequency is not incidence — do not compare it to the clinical rate as if the two measured the same thing.

Want per-drug rates?

This table pools across drugs. If you need rates per drug (semaglutide oral and injectable, tirzepatide, liraglutide, dulaglutide, exenatide, lixisenatide) with the trial arm behind every figure, see the GLP-1 competitor tolerability benchmark: a free gastrointestinal sample is on the page and as a PDF; the full benchmark (all tracked effects, per drug) is a paid product prepared to order. Custom data work and the free API: https://magistra.health/en/data-api

Example row

effect	clinicalPooledRatePct	95% interval	clinicalStatedRates	clinicalDistinctSources
nausea	20.4	6–51	232	75

Columns (`glp1-aggregate-rates.csv`)

Column	Meaning
`effect`, `effectName`	Effect id and display name
`severity`	Magistra's severity tag: mild / moderate / severe
`clinicalPooledRatePct`	Weighted random-effects pooled rate (%) across eligible clinical and regulatory rate points, one entry per distinct source. Empty when the corpus has no eligible clinical rate for the effect
`clinicalCiLowPct`, `clinicalCiHighPct`	95% interval bounds (%)
`clinicalStatedRates`	Rate rows behind the estimate (a registry row is one arm of one trial — rows, not independent observations)
`clinicalDistinctSources`	Distinct sources (studies) behind the estimate
`clinicalSourceDiversity`	Bucket of distinct-source count (e.g. moderate / high / very_high)
`clinicalRateKind`	`incidence`; `serious_ae_floor` when every source is a registry serious-adverse-event rate (a floor on all-cause incidence); `mixed_incidence_and_serious_ae` when the pool contains both
`clinicalIntervalBasis`	`sampling_plus_between_study` normally; `sampling_only_single_source` when one source contributes (heterogeneity term is 0 by construction — do not read the narrow interval as stronger evidence)
`clinicalPhase1Sources` … `clinicalPhase4Sources`	Distinct ClinicalTrials.gov sources by trial phase. Non-registry sources count toward none, so these need not sum to `clinicalDistinctSources`
`communityReportingFrequencyPct`	Share of the screened community reports that mention the effect. Not an incidence rate
`communityMentions`	Reports mentioning the effect
`communityTotalReports`	Denominator: distinct screened community reports, the same for every effect (42 in this snapshot)

The JSON file carries the same rows under effects, plus methodologyNote (full definitions), evidentiaryBase (corpus counts), knownDefect, countCaveat, disclaimer and the licence fields.

Corpus behind this snapshot

3,010 data points across the tracked effects; 2,053 state a rate; 1,832 pass the eligibility screen; 78 distinct studies. The point-level corpus itself is not included and is not under this licence.

Limitations

Pooled across drugs, doses and populations. These are not per-drug rates and are not placebo-adjusted.
Rows are not participants. Some crossover and dose-escalation trials post the same people in several arms; see countCaveat in the JSON for the studies affected and their effect on the counts.
Registry thresholds. Registries list non-serious adverse events only above each trial's reporting threshold (usually 5%), which biases low-frequency rates upward.
A corrected registry sampling bias (disclosed 2026-09-10, corrected 2026-09-16) is described in knownDefect in the JSON.
Community track is small and not growing. Patient-community collection (Reddit) has been blocked since 2026-05-28, so reporting frequencies rest on a fixed, screened set of 42 reports and carry self-selection bias.
Emotional blunting has no citable clinical rate; its clinical columns are empty.
Dated snapshot. Live figures: https://magistra.health/api/data?q=overview

Method: https://magistra.health/en/methodology · Code (Apache-2.0): https://github.com/saurabhgoyal75/magistra-predictor

Licence and citation

CC BY 4.0. Attribution: Magistra, magistra.health. Suggested citation (from the JSON's citation field):

Magistra Health. "GLP-1 Aggregate Pooled Side Effect Rates." magistra.health/data/glp1-aggregate-rates.json. Accessed 2026-10-04.

Published by Phlo Systems B.V. (Magistra). Contact: saurabh@magistra.health

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