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42,125,794 | Secondary Prevention After Coronary Artery Bypass Graft Surgery: 2026 Update: A Scientific Statement From the American Heart Association. | Coronary artery bypass grafting is a well-established, durable, and safe surgical intervention. However, coronary artery disease continues to progress after the procedure. Patients who have undergone bypass surgery present unique challenges in terms of secondary prevention resulting from the often severe and diffuse na... |
42,125,665 | Identification of biomarkers in diabetic neuropathy: a Mendelian randomization and bioinformatics analysis. | This study elucidated several plasma proteins that are causally linked to the risk of diabetic neuropathy (DN), offering novel insights into the protein-mediated DN pathogenesis and potential targets for therapeutic intervention. We employed Mendelian randomization (MR) utilizing genome-wide association study (GWAS) da... |
42,125,629 | Neutrophil-Percentage-to-Albumin Ratio and Monocyte-to-Albumin Ratio: Utility of the Combined Biomarkers in the Prediction of 30-Day Mortality in Male Diabetes Patients Over 80 Years Old with Bloodstream Infections. | Elderly patients with diabetes mellitus (DM) are highly vulnerable to bloodstream infections (BSI), which lead to a significantly high risk of mortality. Novel inflammatory markers that attach to albumin, such as Neutrophil-percentage-to-albumin ratio (NPAR), C-reactive protein-to-albumin ratio (CAR), Monocyte-to-album... |
42,125,581 | Changes in the Mental Health Status of Rural Community-dwelling Elderly Over a Decade in Puducherry, South India: A Panel Study. | Population aging is causing the rise in physical and mental illnesses, leading to the higher disability among the elderly. Despite advancements in healthcare, neglect of mental healthcare negatively impacts quality of life. Changes in the mental health status of the elderly people over time remains unexplored. To asses... |
42,125,565 | Proportion of Presumptive Knee Osteoarthritis and its Predictors among Adults In Al-Qunfudah Governorate, Saudi Arabia: An Analytical Cross-Sectional Study. | Knee osteoarthritis (OA) is a common joint disease that increases with age and negatively affects quality of life. This study aimed to assess the proportion of presumptive knee OA and its predictors among the adults in Al-Qunfudah governorate, Saudi Arabia. An analytical cross-sectional study that included a convenienc... |
42,125,531 | Coil embolization for giant left anterior descending artery aneurysm with coronary pulmonary artery fistula in an elderly patient: a case report. | Giant coronary artery aneurysms (CAAs), defined as dilatations exceeding 20 mm or four times the reference vessel diameter, are rare and risk rupture or thrombosis. Coronary pulmonary artery fistulas may lead to grow aneurysm formation via chronic high-flow shunting. Their coexistence is rare in elderly patients withou... |
42,125,413 | Crusted scabies complicated by septic shock: a fatal case report with incidental detection of Sarcoptes scabiei DNA in peripheral blood. | Crusted scabies is a severe form of scabies characterized by massive mite burden and profound immune dysregulation. Secondary bacterial infection is common and may progress to sepsis with fatal outcomes. We report a fatal case of crusted scabies complicated by septic shock in a 58-year-old man with diabetes mellitus an... |
42,125,284 | From the NOD Mouse to Patients: Type 1 Conventional Dendritic Cells as a Therapeutic Target in Type 1 Diabetes. | Type 1 diabetes (T1D) is an autoimmune disease characterized by CD8<sup>+</sup> T cell mediated destruction of pancreatic β cells, leading to insulin deficiency. The non-obese diabetic (NOD) mouse is widely used as an experimental model for T1D because it closely mirrors the genetic and immune characteristics of the hu... |
42,125,237 | Association between estimated pulse wave velocity and impaired fasting glucose: a multicenter retrospective cohort study in China. | Prediabetes, primarily impaired fasting glucose (IFG), represents a critical window for preventing diabetes and its vascular sequelae. Estimated pulse wave velocity (ePWV) is a noninvasive marker of aortic stiffness and a predictor of cardiovascular events. Although arterial stiffness is linked to early glucose metabol... |
42,125,236 | Developing and validating a clinlabomics-based machine-learning model for early detection of occult diabetic kidney disease: implications for primary care screening. | Occult diabetic kidney disease (DKD) is a subtle yet high-risk microvascular complication of type 2 diabetes mellitus (T2DM). Early-stage DKD often goes undetected because traditional screening markers remain within the normal range. This study aimed to develop and validate an explainable machine learning (ML) model us... |
42,125,231 | Building the evidence to address disparities in type 1 diabetes (BEAD-T1D): methods and design of a study examining barriers and promoters to diabetes device use in families with public insurance. | Continuous glucose monitoring (CGM) and automated insulin delivery (AID) systems have led to improved outcomes in type 1 diabetes (T1D). Diabetes technology use in minoritized populations is 50% lower than more privileged groups. Tailored, multi-factorial interventions are needed to address disparities and improve tech... |
42,125,228 | Comparative predictive value of the cholesterol-high-density lipoprotein-glucose index versus the triglyceride-glucose index for gestational dysglycemia: a two-cohort study. | Early risk stratification for gestational dysglycemia is important for improving maternal and neonatal outcomes. Derived from fasting triglycerides and glucose, the triglyceride-glucose (TyG) index is widely used to approximate insulin resistance, whereas the cholesterol-high-density lipoprotein-glucose (CHG) index inc... |
42,125,032 | Trends in Age-Adjusted Cardiovascular Mortality Rates Among the Diabetic Population of the United States: 1999-2020, CDC WONDER Retrospective Study. | This study examines trends in cardiovascular disease (CVD)-related mortality among individuals with diabetes mellitus (DM) in the United States from 1999 to 2020, focusing on age-adjusted mortality rates (AAMRs) across demographic and geographic subgroups. Using the CDC WONDER database, we analyzed death certificate da... |
42,124,922 | Cerebral Small Vessel Disease Burden in Saudi Arabia: Epidemiology, Risk Determinants, and Neuroimaging Characteristics. | Cerebral small vessel disease (CSVD) is a major contributor to stroke, cognitive impairment, and gait disturbance. Data describing its burden and determinants in Middle Eastern populations remain limited. This study aimed to estimate the prevalence, clinical predictors, and neuroimaging characteristics of CSVD among ad... |
42,124,894 | Hepatocyte growth factor/c-Met signaling axis in human diseases: Mechanistic insights and therapeutic potential. | Hepatocyte growth factor (HGF) is a multifunctional cytokine that activates the tyrosine kinase activity of its specific receptor, c-Met (mesenchymal-epithelial transition factor). This activation subsequently regulates downstream signaling pathways such as PI3K/Akt and Ras/MEK, ultimately mediating key biological proc... |
42,124,808 | PISA: Inflamed Surface Area of Gums Triggering Systemic Hyperinflammation. | Periodontitis, a chronic inflammatory disease, causes progressive loss of periodontal tissues. Traditional measures like clinical attachment loss and probing pocket depth fail to quantify the inflammatory burden accurately. The Periodontal Inflamed Surface Area (PISA) quantifies the surface area of bleeding pocket epit... |
42,124,782 | Sleeve Gastrectomy With Proximal Jejunal Bypass: Balancing Simplicity and Efficacy in Metabolic and Bariatric Surgery. | Sleeve gastrectomy with proximal jejunal bypass (SG-PJB) is a simplified sleeve-plus procedure designed to augment the metabolic impact of sleeve gastrectomy while avoiding the long-term complications associated with Roux-en-Y gastric bypass (RYGB). Early studies demonstrate that SG-PJB achieves diabetes remission and ... |
42,124,529 | Aggregation-driven expression of liraglutide precursors using engineered mini-tags in Escherichia coli. | Glucagon-like peptide-1 (GLP-1), a 31-amino acid incretin hormone, is widely used in the treatment of type 2 diabetes mellitus due to its glucose-dependent insulinotropic activity. However, its small size makes it highly prone to proteolytic degradation in microbial expression systems such as Escherichia coli, leading ... |
42,124,522 | Body mass index and peripheral neuropathy across the glucose tolerance spectrum in Japanese adults. | To examine the association between obesity, defined using population-specific body mass index (BMI) thresholds, and peripheral neuropathy across the glucose tolerance spectrum in Japanese adults. This cross-sectional study included 353 Japanese adults: 90 with normal glucose tolerance (NGT), 55 with impaired glucose to... |
42,124,400 | Potential Impact of Revising the Diagnostic Criteria for Gestational Diabetes on Maternal Pregnancy and Infant Perinatal Outcomes. | The revised diagnostic criteria for gestational diabetes (GDM) in New Zealand include lowering the fasting glucose from the current ≥ 5.5 to ≥ 5.3 mmol/L and replacing the current 2-h post-load glucose (≥ 9.0 mmol/L) with a 1-h glucose (≥ 10.6 mmol/L). We assessed the effects of these changes on the demographics of tho... |
42,124,391 | Multimodal fusion of brain imaging and proteomics reveals a brain-body pathway linking depression and metabolic dysfunction. | Depression is associated with pathological dysregulations affecting both the brain and the body, with the latter being reflected in plasma proteins. While plasma protein signatures of depression have been increasingly recognized, a holistic examination of interactions with brain features is lacking. Leveraging data fro... |
42,124,340 | A 48-Year-Old Man With Diabetic Ketoacidosis, Hypothermia, and Cardiac Arrest Managed With Veno-Arterial Extracorporeal Membrane Oxygenation. | BACKGROUND Insulin deficiency can cause hypothermia by preventing glucose uptake into cells, and acidosis can impair metabolic rate. Diabetic ketoacidosis (DKA) and a body temperature <35°C (hypothermia) is a combination with a high mortality rate due to refractory cardiocirculatory collapse and requires emergency mana... |
42,124,333 | Understanding interconception experiences of women with previous gestational diabetes mellitus across Ireland. | To explore the interconception experiences of women after GDM across Ireland to inform how to optimise health between pregnancies. A qualitative descriptive study was implemented. Online semi-structured individual interviews were conducted (April-May 2025) with women living on the island of Ireland who had experienced ... |
42,124,073 | The 2024 Endocrine Society Guideline on Vitamin D: Comprehensive Summary and Critical Appraisal. | An Endocrine Society Clinical Practice Guideline on vitamin D was published in 2024. Its main objective was the use of vitamin D to lower the risk of disease in individuals without established indications for vitamin D treatment or 25-hydroxavitamin D (25(OH)D) testing. The methodology followed the Grading of Recommend... |
42,124,068 | Facilitators and Barriers of Adherence to Time-Restricted Eating in Individuals with Type 2 Diabetes: A Qualitative Study. | Time-restricted eating (TRE) has shown promise for improving glycemic control and supporting weight management in individuals with Type 2 Diabetes Mellitus (T2DM). However, limited evidence exists regarding factors that influence adherence to TRE in this population. This study aimed to explore the experiences of adults... |
42,124,057 | Association of Maternal and Cord Blood Choline and Betaine Concentrations with Birthweight: A Prospective Mother-Infant Cohort Study. | <b>Background:</b> Experimental studies indicated that maternal choline and betaine status have the potential to alter fetal growth, but epidemiological data remain sparse. <b>Objective:</b> We aimed to investigate the association of maternal and cord blood choline and betaine concentrations with birthweight outcomes. ... |
42,124,030 | Cardiovascular-Kidney-Metabolic (CKM) Syndrome Staging and Relevance to Precision Nutrition. | <b>Background/Objectives:</b> It is estimated that one in three adults in the US has one or more risk factors for cardiovascular-kidney-metabolic (CKM) syndrome. The American Heart Association (AHA) has warned that the interaction between obesity, Type 2 diabetes (T2D), chronic kidney disease (CKD), and cardiovascular ... |
42,124,025 | Evaluation of School Lunch Quality in Accordance with the Quality Standard for Meals in Schools of the German Nutrition Society in a Selection of Thuringian Schools. | <b>Background:</b> School meals are crucial for children's development and can contribute to the prevention, amongst others, of obesity and type 2 diabetes mellitus. We analyzed the conformity of meal composition with the quality standard for meals in schools (QST) of the German Nutrition Society (DGE) and reference va... |
42,124,017 | Carbohydrate Knowledge in People with Type 1 and Type 2 Diabetes in the NutriNet-Santé Cohort Study. | <b>Background:</b> Effective glycemic control in diabetes management relies heavily on dietary carbohydrate knowledge. This study aimed to assess carbohydrate knowledge in individuals with type 1 diabetes (T1D) and insulin-treated type 2 diabetes (itT2D) using the GluciQuizz tool. <b>Methods:</b> A total of 465 persons... |
42,124,008 | Maternal Diet, Lifestyle Factors, and Gestational Weight Gain: A Single-Center Case-Control Study in Hungary. | Preterm birth (PTB) is a major public health concern worldwide, which may lead to detrimental maternal and neonatal outcomes. Maternal nutritional status, gestational weight gain (GWG), and lifestyle factors are potentially modifiable determinants of adverse pregnancy outcomes. This study examined the association betwe... |
42,124,007 | Vitamin D in Type 2 Diabetes Mellitus According to Diabetic Kidney Disease Stage: What Is the Target in Clinical Practice? | <b>Background/Objectives:</b> Low vitamin D (VD) has been associated with diabetic kidney disease (DKD). Nevertheless, VD normality concentrations remain under discussion. <b>Objectives:</b> To evaluate VD concentrations in early and advanced DKD stages according to the Endocrine Society and Institute of Medicine stand... |
42,123,992 | Effects of Dietary Fruit and Vegetable Consumption on Prediabetes: A Systematic Review and Meta-Analysis. | <b>Background/Objectives</b>: Previous studies have reported inconsistent findings regarding the association between fruit and vegetable consumption and prediabetes. Therefore, we aimed to investigate this association using a meta-analysis, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyse... |
42,123,983 | Adipocyte Size, Overweight, and Insulin Resistance in Type 2 Diabetes Mellitus and the Impact of Weight Loss: A Systematic Review. | <b>Background:</b> The impact of overweight and adipocyte size on the development of type 2 diabetes mellitus (T2DM) remains unclear. <b>Aim:</b> We studied (1) the relationship between the state of adipocytes and/or overweight/obesity, the development of T2DM and its clinical and laboratory features; and (2) weight lo... |
42,123,959 | Carob (<i>Ceratonia siliqua</i> L.) in Glucose Homeostasis and Energy Balance: The Role of D-Pinitol. | The global rise in obesity and metabolic disorders has intensified interest in dietary bioactives capable of improving glycemic control and metabolic health. Inositols, particularly D-pinitol, have emerged as insulin-sensitizing cyclitols with potential metabolic relevance. Carob (<i>Ceratonia siliqua</i> L.), one of t... |
42,123,882 | Inhibition of Glucose-Induced Glycation of HSA by Pioglitazone: Multi-Spectroscopic and Bioinformatic Evidence. | Diabetes mellitus is a growing health concern that causes numerous complications. Glycation produces advanced glycation end-products (AGEs), which promote diabetic complications. Targeting glycation is a strategy for combating the progression of diabetic complications. Pioglitazone enhances insulin sensitivity in patie... |
42,123,847 | Natural Products as NLRP3 Inflammasome Inhibitors: A Review. | An essential multiprotein complex in the innate immune system is the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome. Through the coordination of upstream sensors and the adaptor protein ASC, which converge on the inflammasome complex in response to pathogens and cellular homeostatic disruption... |
42,123,812 | Shichangpu-Xiyangshen Herb Extract Alleviates Cognitive Dysfunction in Type 1 Diabetes Through Metabolism of Arachidonic Acid Cyclooxygenase and Lipoxygenase. | <b>Background</b>: Long-term diabetes mellitus may precipitate severe complications, including cognitive dysfunction. Existing research has shown that diabetic cognitive impairment (DCI) in rats is characterized by memory deterioration and a disordered arrangement of hippocampal cells. The Shichangpu-Xiyangshen herb pa... |
42,123,763 | Understanding the Antihyperglycemic Activity of <i>Annona cherimola</i> Leaves. An Edible and Medicinal Plant in Mexico: <i>In Vivo</i> and <i>Ex-Vivo</i> Studies. | <i>Annona cherimola</i> is a plant species widely used in Mexican traditional medicine, particularly in the management of diabetes. This study aimed to investigate the antihyperglycemic properties of the petroleum ether extract of <i>A. cherimola</i> leaves (PEEAcL), as well as to evaluate their effects on glycated hem... |
42,123,756 | Transcriptomic Profiling Combined with Machine Learning and Mendelian Randomization Identifies Diagnostic Biomarkers and Immune Infiltration Patterns in Diabetic Kidney Disease. | Diabetic kidney disease (DKD) affects approximately 40% of patients with diabetes mellitus and remains a leading cause of end-stage renal disease worldwide. Early diagnosis and identification of therapeutic targets are critical for improving patient outcomes, yet reliable biomarkers are lacking. This study integrated t... |
42,123,728 | Inflammatory Proteomic Heterogeneity Beyond Glycemia Status in Severe Obesity. | Chronic low-grade inflammation is a key feature of obesity-associated dysglycemia, yet substantial heterogeneity exists in inflammatory responses among individuals with normoglycemia, prediabetes, and type 2 diabetes mellitus (T2DM). Whether circulating inflammatory protein profiles define distinct patient phenotypes b... |
42,123,679 | Targeting the Gut-Heart Axis in Diabetic Heart Failure: Microbiota and SGLT2is as Converging Therapeutic Frontiers. | Emerging evidence highlights the gut microbiota as a critical modulator in the pathogenesis of heart failure (HF), particularly among patients with type 2 diabetes mellitus (T2DM). Dysbiosis contributes to systemic inflammation, endothelial dysfunction, and adverse cardiac remodeling via microbial metabolites such as t... |
42,123,657 | Betaine Alters the Interplay of the Adenosine and <i>NO</i> Systems in the Control of Renal Regional Haemodynamics and Excretion in Diabetic Female Rats. | We showed recently that the adenosine system and nitric oxide (<i>NO</i>) can interact differently in the control of renal function in normoglycaemia (NG) versus streptozotocin-induced diabetes (DM). Herein, we investigated if this relationship is modulated by dietary betaine (Bet, food compound possessing antioxidant ... |
42,123,643 | Explaining Retinal Susceptibility to Diabetes Through Photoreceptor Biology. | While diabetic retinal disease (DRD) has classically been viewed as a microvascular complication, emerging evidence places the photoreceptor at the center of its pathogenesis. Recognizing this central role provides a critical framework for resolving a major clinical paradox in diabetes: why the retina exhibits profound... |
42,123,628 | Placental Mesenchymal Stem Cell-Derived Extracellular Vesicles (PMSC-EVs) as an Innovative Therapy for Diabetic Wound Healing. | Individuals with diabetes mellitus (DM) experience impaired wound healing, where the healing process is often compromised by a complex, hostile microenvironment characterized by persistent inflammation, high oxidative stress, and dysfunctional angiogenesis. The hyperglycemic environment damages the blood vessels and di... |
42,123,593 | Multi-Axis Reprogramming of Muscle-Metabolic Crosstalk by HiLo Platinum™ Restores Strength in Prediabetes via Mitochondrial Activation and Gut Microbiome Remodeling. | Prediabetes is increasingly recognized as a risk factor for sarcopenia, driven by chronic low-grade inflammation, insulin resistance, and impaired anabolic signaling. Nutritional interventions containing whey protein, hydroxymethylbutyrate (HMB), glucosamine, and micronutrients may offer a multi-target strategy to coun... |
42,123,553 | The Role of Antidiabetic Therapies in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review of Metformin, Pioglitazone, and GLP-1 Receptor Agonists. | Alzheimer's disease (AD) and mild cognitive impairment (MCI) are major causes of cognitive decline. Antidiabetic medications such as metformin, pioglitazone, and GLP-1 receptor agonists have been proposed as potential neuroprotective therapies. We assessed whether these agents slow cognitive decline or disease progress... |
42,123,550 | Operon™ Platform-Enabled for Cardiometabolic Biomarker Screening and Precision Treatment Strategies: A Type 2 Diabetes-Centered Review with Cardiovascular Extension. | Cardiometabolic diseases, encompassing obesity, insulin resistance, type 2 diabetes (T2D), metabolic dysfunction-associated steatotic liver disease (MASLD), hypertension, and atherosclerotic cardiovascular disease (ASCVD), represent a vast continuum driven by multi-organ network dysregulation. Clinical risk assessment ... |
42,123,503 | The Insulin-Urothelial Axis: Evaluating Insulin Resistance as a Convergent Driver of Bladder Cancer Across Diverse Risk Factor Profiles. | Growing evidence suggests that insulin resistance (IR) might be a core, unifying mechanism linking various established risk factors for bladder cancer (BC). While factors like smoking, central obesity, sedentary lifestyle, and high-fat diets are known to increase BC risk, a common thread among them is their role in dri... |
42,123,497 | Comprehensive Review of Hydrogel-Mediated Strategies for Diabetic Wound Healing. | Diabetic chronic wounds (particularly diabetic foot ulcers) are difficult to heal due to factors such as high glucose levels, infection, and inflammatory imbalance. In severe cases, they can lead to tissue necrosis and amputation. Hydrogel materials, as moist wound dressings, possess high water content, biocompatibilit... |
42,123,481 | Relative Leukocyte Telomere Length Is Shorter in Children and Adolescents with Type 1 Diabetes: Screening of Basic Psychosocial Aspects. | Leukocyte telomere length (LTL) is shortened in adults with type 1 diabetes (T1D), but less data is available concerning pediatric cases. Multiple factors affect LTL, namely genes, epigenetics, environmental factors, oxidation, and psychological stress. Children with T1D and their families experience chronic stress. Th... |
42,123,472 | Metabolic Benefits vs. Cardiovascular Uncertainty: A Critical Review of GLP-1 Receptor Agonists in Type 1 Diabetes. | Type 1 diabetes (T1DM) is associated with elevated cardiovascular (CV) risk, often exacerbated by the rising prevalence of obesity. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) reduce CV risk in type 2 diabetes, but their role in T1DM is less well-defined. This umbrella review synthesizes evidence from systema... |
42,123,471 | Therapeutic Peptides in Aesthetic, Metabolic and Endocrine Conditions: Effects, Safety, Clinical Applications, and Future Perspectives. | Therapeutic peptides are short chains of amino acids used to treat metabolic and endocrine conditions such as obesity and type 2 diabetes. While several peptide drugs have undergone rigorous approval processes that evaluate both safety and efficacy, novel, unapproved compounds have emerged and are rapidly expanding int... |
42,123,447 | Advances in the Role of the CD40-CD154 Pathway in the Pathogenesis of Diabetic Retinopathy. | Diabetic retinopathy is one of the most important complications of diabetes. It is a leading cause of visual loss in the world. While adequate control of hyperglycemia, hypertension and hyperlipidemia can decrease the prevalence of diabetic retinopathy, 60% of patients with type 2 diabetes develop this complication whe... |
42,123,439 | Curcumin Supplementation Reduces Inflammation, Neutrophil-to-Lymphocyte Ratio (NLR), and Antioxidant Status in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial. | Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and impaired insulin secretion, and curcumin-a polyphenolic compound derived from <i>Curcuma longa</i>-has shown potential anti-inflammatory and antioxidant effects. This randomized, double-blind, placebo-controlled tria... |
42,123,427 | Plasma Proteomic Signatures of Glucose Metabolism Disturbances and Early Diabetes. | Postprandial variability in glucose and protein levels is one of the elements of insulin resistance (IR) and prediabetes, which is an area precursor to type 2 diabetes mellitus (DM). The objective of the study was a comprehensive proteomic analysis according to glucose tolerance in the general population who did not se... |
42,123,337 | Vascular Endothelial Growth Factor and Placental Growth Factor in Conjunction with Vascular Endothelial Growth Factor Receptor-1 May Exert Dual Effects Within the Kidney and Brain in Patients with Type 2 Diabetes Mellitus and Normoalbuminuric Diabetic Kidney Disease. | The kidney and the brain share similarities in terms of structure and haemodynamic regime. The aim of the study was to assess a potential correlation of vascular endothelial growth factor (VEGF), soluble vascular endothelial growth factor receptor-1 (sFlt-1), and placental growth factor (PlGF) with biomarkers of podocy... |
42,123,336 | Nutritional Interventions to Optimize Orthobiologic Therapy Quality in Type 2 Diabetes Mellitus: Molecular Mechanisms and Clinical Framework: A Narrative Review. | Type 2 diabetes mellitus (T2DM) affects approximately 10-25% of patients undergoing orthopedic procedures and is associated with impaired tissue healing, increased complication rates, and reduced responsiveness to orthobiologic therapies, including platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), an... |
42,123,262 | Clinical Outcomes of Insulin Glargine U300 on Glycemic Control and Hypoglycemia: A Retrospective Observational Study. | <b>Background/Objectives:</b> Insulin glargine U300 (IGlarU300) is a second-generation, long-acting insulin analog designed to provide a more stable pharmacokinetic profile compared to insulin glargine U100. However, long-term real-world data reflecting its long-term impact on glycemic control and hypoglycemia across d... |
42,123,251 | Intentional Insulin Omission (Diabulimia) in Patients with Insulin-Dependent Diabetes: An Eating Disorder? A Systematic Review. | <b>Background/Objectives:</b> Intentional insulin omission (IIO), commonly referred to as diabulimia, is a high-risk behavioural phenomenon observed mainly in adolescents and young adults with type 1 diabetes mellitus (T1D). Defined as the deliberate reduction or omission of insulin to influence body weight, IIO lies a... |
42,123,220 | Finerenone Across the Cardiovascular-Kidney-Metabolic Continuum: From Mechanistic Rationale to Clinical Positioning-A Narrative Review. | The cardiovascular-kidney-metabolic (CKM) syndrome has emerged as an integrated framework linking obesity, type 2 diabetes, chronic kidney disease (CKD), and heart failure with preserved or mildly reduced ejection fraction through shared mechanisms including inflammation, oxidative stress, endothelial dysfunction, and ... |
42,123,154 | Comorbidity in Patients with Idiopathic Pulmonary Fibrosis: Evaluation Using the Charlson, TORVAN and GAP Indices. | <b>Introduction</b>: Idiopathic pulmonary fibrosis (IPF) is associated with high morbidity and mortality and a substantial burden of comorbidities, which may influence prognosis and survival. This study aimed to evaluate the burden of comorbidity in patients with IPF receiving antifibrotic therapy using the Charlson, T... |
42,123,127 | SGLT2 Inhibitors in Clinical Practice: Cardiorenal Benefits and Risk of Fungal Infections-A Nephrologist's Perspective. | People affected by diabetes mellitus (DM), chronic kidney disease (CKD), or heart failure are often prescribed sodium-glucose cotransporter-2 inhibitors (SGLT2is) as a method of treatment. These drugs favorably affect glucose metabolism, as patients taking them have lower serum glucose levels. Another promising positiv... |
42,123,121 | Impact of Acute Pancreatitis Aetiology on Long-Term Outcomes Following a First Episode of Acute Pancreatitis: A Systematic Review and Meta-Analysis. | <b>Background</b>: Acute pancreatitis (AP) is increasingly recognised as a disease with clinically significant long-term consequences. However, the extent to which aetiology influences the spectrum of long-term pancreatic sequelae remains unclear. This systematic review and meta-analysis evaluated long-term complicatio... |
42,123,062 | The Potential Indirect Impact of GLP-1 Receptor Agonists in the Management of Fibromyalgia. | <b>Background/Objectives:</b> Fibromyalgia (FM) syndrome is characterised by constant and pervasive musculoskeletal pain and may be comorbid with obesity. Glucagon Peptide-1 Receptor Agonists (GLP-1RAs) are relatively new pharmacotherapies developed for the treatment of type 2 diabetes mellitus (T2DM) and have been rep... |
42,123,033 | Association of Serum <i>P</i>-Cresyl Sulfate Level with Peripheral Artery Disease in Kidney Transplantation Patients. | <b>Background</b>: <i>p</i>-Cresyl sulfate (PCS) has been linked to vascular dysfunction through endothelial injury and vascular remodeling. Peripheral artery disease (PAD), identified by a low ankle-brachial index (ABI), is associated with increased mortality in kidney transplant (KT) recipients. This study investigat... |
42,123,019 | Natural Language Processing of Unstructured Healthcare Data for Predicting Heart Failure in Individuals with Type 2 Diabetes. | <b>Background/Objectives</b>: Type 2 diabetes mellitus (T2DM) is a multisystemic disease with overlapping metabolic, renal, and cardiovascular effects. Within the Diabetic@ project, which aims to characterize individuals with T2DM using real-world data extracted from electronic health records (EHRs), this substudy soug... |
42,122,966 | Higher Plasma Sphingosine-1-Phosphate Levels in Type 2 Diabetic Patients Have a Non-Linear Relationship with the Disease Prognostic Indices and Microvascular Complications: A Cross-Sectional Saudi Study. | <b>Background/Objectives:</b> Sphingosine-1-phosphate (S1P) is implicated in glycemic control. However, its circulating levels and clinical significance in type 2 diabetes mellitus (T2DM) remain controversial. We assessed plasma S1P levels in T2DM patients, its associations with metabolic parameters and complications, ... |
42,122,927 | Advantages of Continuous and Non-Invasive Glucose Monitoring in the Geriatric Population: A Systematic Review. | <b>Background:</b> The global aging population faces an increasing prevalence of type 2 diabetes mellitus (T2DM), often complicated by frailty, cognitive decline, and impaired manual dexterity. These factors make glucose self-monitoring particularly challenging. Minimally invasive glucose monitoring methods, particular... |
42,122,621 | An Exploratory Analysis of Postural Control in People with Type 2 Diabetes Mellitus Using a Smartphone IMU Sensor. | There is a growing need for highly accessible and simplified methods to track postural control in adults affected by neurodegenerative diseases. Therefore, the aim of this study was to assess the validity of smartphone-derived postural control analyses compared with traditional center-of-pressure (COP) measures in heal... |
42,122,394 | Artificial Intelligence for Blood Glucose Level Prediction in Type 1 Diabetes: Methods, Evaluation, and Emerging Advances. | Blood glucose level (BGL) prediction, by providing early warnings regarding unsatisfactory glycaemic control and maximising the amount of time BGL remains in the target range, can contribute to minimising both acute and chronic complications related to diabetes. This paper aims to provide an overview of data-driven app... |
42,122,388 | Usability Evaluation and Perceived Performance of the MoonWalking<sup>®</sup> Insole in Safety Footwear. | Prolonged standing and repetitive lifting are routine occupational stressors that elevate plantar pressures across workers. In those with diabetes, these demands represent additional risk factors for diabetic foot pathology, highlighting the need for ergonomic interventions beyond standard safety footwear. This study e... |
42,122,098 | Exploratory Analysis of Dental Age Differences in Children with Type 1 Diabetes Using the Demirjian Method. | <b>Background:</b> Chronological age does not always accurately reflect biological maturation in children, particularly in the presence of systemic conditions. Dental age is widely used as a biological maturity indicator; however, the impact of Type 1 diabetes mellitus on dental development remains unclear and inconsis... |
42,122,091 | Admission Biomarkers as Predictors of Mortality in Comatose Patients in the Intensive Care Unit: A Retrospective Pilot Study. | <b>Background</b>: Intensive care units (ICUs) provide management of critically ill patients requiring continuous monitoring and complex therapeutic interventions. The aim of this study was to analyze the clinical and biological characteristics associated with mortality in patients admitted to the intensive care unit. ... |
42,122,063 | Variation in the Circulating Levels of Retinoic Acid and Type 2 Diabetes: Relationships with Glycemic Control Indices, Disease Treatment and Complications. | <b>Background/Objectives:</b> Type 2 diabetes mellitus (T2-DM) is a continuing national and global health challenge. Retinoic acid (RA), the major transcription-regulating ligand, plays a critical role in energy metabolism, and pancreatic β-cell homeostasis. However, human data linking circulating RA levels to T2-DM an... |
42,122,054 | Tc-99m DMSA Radiomics in CKD: Phenotype-Specific Cortical Signatures and a Morphological Predictor of Renal Function Decline. | <b>Purpose</b>: This study aims to evaluate the ability of radiomic features obtained from technetium-99m dimercaptosuccinic acid (Tc-99m DMSA) planar images to distinguish renal cortical uptake patterns among patients with chronic kidney disease (CKD). We also assessed the association between selected radiomic feature... |
42,122,006 | Driveline Infections in Durable LVAD Support: Risk Factors, Microbiology, and Resistance Patterns from a Large Cohort. | <b>Background</b>: Driveline infection (DLI) is the most common device-specific infection in patients supported with ventricular assist devices (VADs) and remains a major cause of morbidity during long-term mechanical circulatory support. This study aimed to evaluate the incidence, risk factors, microbiological charact... |
42,121,671 | Determinants of Quality of Life in Saudi Adults with Type 2 Diabetes Mellitus: A Cross-Sectional Study in Jeddah. | This study aimed to assess quality of life (QoL) and its determinants among Saudi adults diagnosed with type 2 diabetes mellitus (T2DM). A cross-sectional study was conducted among 200 (45% male and 55% female) Saudi adults with T2DM aged 30-65 years. Data were collected using the Audit of Diabetes-Dependent Quality of... |
42,121,669 | Drug Safety in Hospitalized Diabetes Patients: A Retrospective Analysis of Predictors and Clinical Relevance of Potential Drug-Drug Interactions. | <b>Background</b>: Diabetes mellitus is frequently associated with complications and comorbidities that often require hospitalization and the use of multiple medications for effective management. However, the simultaneous use of these treatments significantly increases the risk of potential drug-drug interactions (pDDI... |
42,121,641 | Patient-Related Factors Associated with Mechanical Failure After Hemilaminectomy with Posterolateral Fusion: An Exploratory Retrospective Cohort Study. | <b>Background</b>: Implant-related mechanical failure remains a clinically relevant concern following posterior decompression and fusion in elderly patients with lumbar spinal stenosis (LSS). The relative contribution of host-related versus construct-related factors to failure risk requires further clarification. <b>Me... |
42,121,617 | Adult ADHD Symptoms in Syrian War Refugees with Long-Term Health Conditions: A Screening Cross-Sectional Analysis from Jordan. | Attention-deficit hyperactivity disorder (ADHD) in adults is often overlooked in refugees, especially those displaced by war and diagnosed with chronic issues such as hypertension and type 2 diabetes mellitus. We sought to provide a preliminary screening to align with ADHD screening and to examine its related demograph... |
42,121,592 | Exploring the Effects of Dietary, Exercise, and Combined Lifestyle Interventions in the Prevention and Management of Gestational Diabetes Mellitus: A Narrative Review. | <b>Objectives:</b> The objectives of this review are to explore the effects of various nutrition and exercise lifestyle interventions on pregnancy outcomes in individuals with, or at risk of, gestational diabetes mellitus (GDM), as well as to examine whether interventions that are culturally and/or religiously sensitiv... |
42,121,435 | <i>In Silico</i> Structural Characterization and Hypoglycemic Potential of a Novel Fucose-Specific Lectin (MEP5) from <i>Morchella esculenta</i>. | Natural food-derived proteins are increasingly explored as alternatives to synthetic inhibitors for managing Type 2 diabetes mellitus. Despite the recognized health-promoting properties of <i>Morchella esculenta</i>, the potential of its bioactive proteins to modulate glucose metabolism remains largely unexplored. This... |
42,121,319 | Nutrition Interventions Improve Glycemic Control Among People With Type 2 Diabetes in Low- and Middle-Income Countries. A Systematic Review. | The incidence of Type II diabetes (T2D) is increasing rapidly in low- and middle-income countries (LMICs). Dedicated nutrition interventions may be a low-cost low-burden method to improve glycemic control. A systematic review was conducted to explore dedicated nutrition interventions in LMICs for people with T2D. An in... |
42,121,200 | Sodium-glucose cotransporter 2 inhibitors and the risk of kidney cancer among patients with type 2 diabetes: a population-based cohort study. | There is an important need to develop clinical strategies to reduce the risk of incident kidney cancer, especially in patients with type 2 diabetes (T2D) often accompanied by chronic kidney disease. Here, we investigated whether sodium-glucose cotransporter 2 (SGLT2) inhibitor use is associated with reduced kidney canc... |
42,121,155 | MTHFR variants modify the association between pre-pregnancy BMI and postpartum abnormal glucose tolerance among women with gestational diabetes mellitus. | Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and obesity are associated with glucose metabolism dysregulation. This study aimed to investigate the individual and joint effects of MTHFR gene polymorphisms and pre-pregnancy body mass index (pre-BMI) status on postpartum abnormal glucose tolerance (PAGT)... |
42,121,043 | Factors impacting poor hypertension control in young urban adults in a Malaysian primary care clinic. | The prevalence of hypertension among young adults is increasing and with it the risk of cardiovascular events. Thus, this study was conducted to determine the prevalence and factors that are associated with poor BP control in young adults (18-39 years old) in a government primary healthcare centre in Klang Valley, Mala... |
42,120,997 | Glycaemic and Cardiometabolic Outcomes of Empagliflozin Versus Sitagliptin Added to Metformin in T2DM: Insights From a Systematic Review and Meta-Analysis. | Type 2 diabetes mellitus (T2DM) often requires combination therapy when metformin alone becomes insufficient. Empagliflozin (SGLT2 inhibitor) and sitagliptin (DPP-4 inhibitor) are commonly used add-on agents with differing metabolic profiles. This systematic review and meta-analysis compared their glycaemic, cardiometa... |
42,120,930 | The gut microbiota and metabolomics in the pathogenesis of type 2 diabetes mellitus combined with coronary atherosclerotic heart disease. | To investigate the characteristics of intestinal bacteria and their metabolites in healthy controls (CONs) compared with individuals with type 2 diabetes mellitus (T2DM) and individuals with type 2 diabetes mellitus combined with coronary atherosclerotic heart disease (T2DM-CAD). Thirty samples were collected from 10 h... |
42,120,879 | A multi-organ atlas of microcirculatory signatures for systemic profiling of diabetic and therapeutic states. | Microcirculatory deterioration in diabetes mellitus causes severe organ-specific complications, yet a systemic understanding of its cross-organ pathophysiology remains elusive due to a lack of comprehensive data. To address this gap, we present a high-dimensional dataset mapping microhemodynamic and oxygenation profile... |
42,120,867 | Cost-Effectiveness Analysis of PCSK9 Inhibitors in Patients with Atherosclerotic Cardiovascular Disease Without Prior Ischemic Events in Italy. | Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) are an effective class of lipid-lowering drugs in patients with primary hypercholesterolemia or mixed dyslipidemia. New evidence supported the early use of PCSK9i in patients with atherosclerotic cardiovascular disease without prior ischemic events and n... |
42,120,771 | VR-Based Physical Activity and Self-Management Interventions for Glycemic Control and Behavioral Outcomes in Type 2 Diabetes: A Systematic Review and Meta-Analysis. | A growing body of original research has recently investigated virtual reality (VR)-based interventions for physical activity and self-management, yet yielded inconsistent results. This systematic review and meta-analysis aims to evaluate the effectiveness of VR-based physical activity and self-management interventions ... |
42,120,615 | Prevalence and associated factors of anxiety and depression among hemodialysis patients in palestine: a cross-sectional study. | Patients with end-stage renal disease (ESRD) undergoing hemodialysis are at increased risk of anxiety and depression, which may adversely affect treatment adherence and quality of life. Data on the prevalence and determinants of these conditions among Palestinian hemodialysis patients remain limited outside pandemic se... |
42,120,597 | Butyrylcholinesterase as a potential biomarker of metabolic imbalances in Afro-descendant populations. | This study investigated butyrylcholinesterase (BChE) activity and its genetic variants (-116, A, and K) in Afro-Brazilian individuals living in two African-derived communities (quilombos) in southern Brazil. Parameters, including obesity, glucose, and lipid profile, were compared with those of Euro-Brazilian individual... |
42,120,480 | The cardiometabolic index and miR-29a as related biomarkers for insulin resistance and dysglycemia in adults: insights from the KERCADRS study. | The identification of accurate and simple biomarkers for insulin resistance (IR) and type 2 diabetes mellitus (T2DM) is crucial for early risk stratification. This study investigated the association between the Cardiometabolic Index (CMI), A novel lipid-anthropometric composite, as a marker for IR/T2DM and its relation... |
42,120,367 | Heterogeneous endocrine cell composition defines human islet functional phenotypes. | Phenotyping and genotyping initiatives within the Integrated Islet Distribution Program (IIDP), the largest source of human islets for research in the U.S., provide standardized assessment of islet preparations distributed to researchers and enable the integration of multiple data types. Data from islets of the first 2... |
42,120,112 | Hemoglobin Yanase can lead to inaccurate diabetes diagnoses when using HbA1c measurement by HPLC. | Glycated hemoglobin (HbA1c) is essential for diagnosing and monitoring diabetes mellitus (DM). However, hemoglobin (Hb) variants can alter its measurement using high-performance liquid chromatography (HPLC), compromising the patients' diagnosis and follow-up. The limited information in databases such as HbVar and IthaN... |
42,120,111 | Functional dentition and chronic noncommunicable diseases among adults in Brazil. | This study aimed to investigate the association between functional dentition and a prior diagnosis of diabetes mellitus (DM) and/or chronic kidney disease (CKD) in a nationally representative sample of the Brazilian population. We conducted a cross-sectional analysis using data from the 2019 Brazilian National Health S... |
42,120,109 | Comparison of carbohydrate assessment metrics for predicting fasting and postprandial plasma glucose in patients with type 2 diabetes mellitus. | Fasting plasma glucose (FPG) and postprandial plasma glucose (PPG) are critical short-term indicators of glycemic control in type 2 diabetes mellitus (T2DM). Although carbohydrate assessment metrics - carbohydrate (g/d), carbohydrate portion, carbohydrate (%), low carbohydrate diet (LCD) score, carbohydrate to fiber ra... |
42,120,108 | Hypoglycemia in older adults with type 2 diabetes mellitus: Prevalence and associated risk factor: A systematic review and meta-analysis. | Currently, hypoglycemia poses a critical challenge in managing older patients with type 2 diabetes mellitus (T2DM), threatening their long-term health and overall well-being. This meta-analysis is the first to comprehensively quantify the pooled prevalence of hypoglycemia and identify its key influencing factors specif... |
42,120,106 | Serum miR-21 and miR-192 levels in type 2 diabetes: Association with albuminuria and renal function. | Albuminuria is a widely used clinical marker for diabetic nephropathy (DN); however, its limited sensitivity and specificity in detecting early renal alterations highlight the need for additional indicators. MicroRNAs (miRNAs) are emerging as molecular regulators involved in the pathogenesis of DN and may provide insig... |
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