id stringlengths 3 4 | context stringlengths 2.88k 70.8k | answers dict | question stringlengths 11 194 |
|---|---|---|---|
4123 | Frontiers in antiviral therapy and immunotherapy
https://doi.org/10.1002/cti2.1115
SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf
Authors: Heaton, Steven M
Date: 2020
DOI: 10.1002/cti2.1115
License: cc-by
Abstract: nan
Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l... | {
"answer_start": [
292
],
"text": [
"a 'Valley of Death' 1,2 no less, between broadening strides in fundamental biomedical research and their incommensurate reach into the clinic. "
]
} | What growing dysjunction has been witnessed? |
4124 | Frontiers in antiviral therapy and immunotherapy
https://doi.org/10.1002/cti2.1115
SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf
Authors: Heaton, Steven M
Date: 2020
DOI: 10.1002/cti2.1115
License: cc-by
Abstract: nan
Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l... | {
"answer_start": [
502
],
"text": [
" recent changes in the structure of government funding, 2 new public and private joint ventures and specialist undergraduate and postgraduate courses"
]
} | What is aiming to incorporate pathways to translation at the earliest stages? |
4125 | Frontiers in antiviral therapy and immunotherapy
https://doi.org/10.1002/cti2.1115
SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf
Authors: Heaton, Steven M
Date: 2020
DOI: 10.1002/cti2.1115
License: cc-by
Abstract: nan
Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l... | {
"answer_start": [
842
],
"text": [
"exponentially, up 1800%"
]
} | How much have the number of biomedical research publications targeting 'translational' concepts has increased ? |
4126 | Frontiers in antiviral therapy and immunotherapy
https://doi.org/10.1002/cti2.1115
SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf
Authors: Heaton, Steven M
Date: 2020
DOI: 10.1002/cti2.1115
License: cc-by
Abstract: nan
Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l... | {
"answer_start": [
2042
],
"text": [
"by creatively leveraging the so-called 'strengths' of viruses. Viral RNA polymerisation and reverse transcription enable resistance to treatment by conferring extraordinary genetic diversity. "
]
} | What ways to solve the issues are outlined? |
4127 | Frontiers in antiviral therapy and immunotherapy
https://doi.org/10.1002/cti2.1115
SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf
Authors: Heaton, Steven M
Date: 2020
DOI: 10.1002/cti2.1115
License: cc-by
Abstract: nan
Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l... | {
"answer_start": [
2302
],
"text": [
" by strongly limiting virus genome sizes and their incorporation of new information. "
]
} | How do these exact processes ultimately restrict viral infectivity? |
4128 | Frontiers in antiviral therapy and immunotherapy
https://doi.org/10.1002/cti2.1115
SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf
Authors: Heaton, Steven M
Date: 2020
DOI: 10.1002/cti2.1115
License: cc-by
Abstract: nan
Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l... | {
"answer_start": [
2424
],
"text": [
"'information economy paradox'."
]
} | What does the author coin this evolutionary dilemma as? |
4129 | Frontiers in antiviral therapy and immunotherapy
https://doi.org/10.1002/cti2.1115
SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf
Authors: Heaton, Steven M
Date: 2020
DOI: 10.1002/cti2.1115
License: cc-by
Abstract: nan
Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l... | {
"answer_start": [
2492
],
"text": [
"by manipulating multifunctional or multitasking host cell proteins (MMHPs), thereby maximising host subversion and viral infectivity at minimal informational cost."
]
} | How do many viruses resolve this ? |
4130 | Frontiers in antiviral therapy and immunotherapy
https://doi.org/10.1002/cti2.1115
SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf
Authors: Heaton, Steven M
Date: 2020
DOI: 10.1002/cti2.1115
License: cc-by
Abstract: nan
Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l... | {
"answer_start": [
2725
],
"text": [
" via host-oriented therapies to impose devastating informational and fitness barriers on escape mutant selection."
]
} | How may this "Achilles Heel" be safely targeted? |
4131 | Frontiers in antiviral therapy and immunotherapy
https://doi.org/10.1002/cti2.1115
SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf
Authors: Heaton, Steven M
Date: 2020
DOI: 10.1002/cti2.1115
License: cc-by
Abstract: nan
Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l... | {
"answer_start": [
2852
],
"text": [
"since MMHPs are often conserved targets within and between virus families,"
]
} | Why may MMHP-targeting therapies exhibit both robust and broadspectrum antiviral efficacy? |
4132 | Frontiers in antiviral therapy and immunotherapy
https://doi.org/10.1002/cti2.1115
SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf
Authors: Heaton, Steven M
Date: 2020
DOI: 10.1002/cti2.1115
License: cc-by
Abstract: nan
Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l... | {
"answer_start": [
3058
],
"text": [
" break the vicious cycle of escalating therapeutic development costs and trivial escape mutant selection, both quickly and in multiple places. "
]
} | What will achieving this through drug repurposing do? |
4133 | Frontiers in antiviral therapy and immunotherapy
https://doi.org/10.1002/cti2.1115
SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf
Authors: Heaton, Steven M
Date: 2020
DOI: 10.1002/cti2.1115
License: cc-by
Abstract: nan
Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l... | {
"answer_start": [
3215
],
"text": [
" alternative posttranslational and RNA-based antiviral approaches, designer vaccines, immunotherapy and the emerging field of neo-virology."
]
} | What are also discussed by the author? |
4134 | Frontiers in antiviral therapy and immunotherapy
https://doi.org/10.1002/cti2.1115
SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf
Authors: Heaton, Steven M
Date: 2020
DOI: 10.1002/cti2.1115
License: cc-by
Abstract: nan
Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l... | {
"answer_start": [
3429
],
"text": [
" will enable the tapping of useful new biological functions and processes, methods for controlling infection, and the deployment of symbiotic or subclinical viruses in new therapies and biotechnologies that are so crucially needed."
]
} | What does the author anticipate international efforts will do? |
4138 | Frontiers in antiviral therapy and immunotherapy
https://doi.org/10.1002/cti2.1115
SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf
Authors: Heaton, Steven M
Date: 2020
DOI: 10.1002/cti2.1115
License: cc-by
Abstract: nan
Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l... | {
"answer_start": [
3688
],
"text": [
"stimulate expression of numerous host inflammatory factors that support recruitment and activation of immune cells. "
]
} | What do pathogens do upon infection? |
4139 | Frontiers in antiviral therapy and immunotherapy
https://doi.org/10.1002/cti2.1115
SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf
Authors: Heaton, Steven M
Date: 2020
DOI: 10.1002/cti2.1115
License: cc-by
Abstract: nan
Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l... | {
"answer_start": [
3822
],
"text": [
"this same process also causes immunopathology when prolonged or deregulated."
]
} | What is the flip side ? |
4140 | Frontiers in antiviral therapy and immunotherapy
https://doi.org/10.1002/cti2.1115
SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf
Authors: Heaton, Steven M
Date: 2020
DOI: 10.1002/cti2.1115
License: cc-by
Abstract: nan
Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l... | {
"answer_start": [
4022
],
"text": [
"post-transcriptionally control expression of crucial inflammatory factors in various tissues and their potential therapeutic applications"
]
} | What do RBPs do? |
4141 | Frontiers in antiviral therapy and immunotherapy
https://doi.org/10.1002/cti2.1115
SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf
Authors: Heaton, Steven M
Date: 2020
DOI: 10.1002/cti2.1115
License: cc-by
Abstract: nan
Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l... | {
"answer_start": [
4182
],
"text": [
"tristetraprolin and AUF1"
]
} | What is included in RBPs? |
4142 | Frontiers in antiviral therapy and immunotherapy
https://doi.org/10.1002/cti2.1115
SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf
Authors: Heaton, Steven M
Date: 2020
DOI: 10.1002/cti2.1115
License: cc-by
Abstract: nan
Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l... | {
"answer_start": [
4214
],
"text": [
"promote degradation of AU-rich element (ARE)-containing mRNA"
]
} | What do tristetraprolin and AUF1, do? |
4143 | Frontiers in antiviral therapy and immunotherapy
https://doi.org/10.1002/cti2.1115
SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf
Authors: Heaton, Steven M
Date: 2020
DOI: 10.1002/cti2.1115
License: cc-by
Abstract: nan
Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l... | {
"answer_start": [
4276
],
"text": [
"members of the Roquin and Regnase families"
]
} | What do RBPs include? |
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