Taykhoom/functional-multiclass-gamba

GAMBA Functional Region Multiclass

This dataset packages GAMBA's multiclass functional-region benchmark. Each row is an annotated feature labeled by its functional category.

The full-region and 100 bp pooling variants are separate Hugging Face configs. Both retain the same GAMBA-oriented context sequence; pool_start and pool_end select either the complete ROI or a deterministic 100 bp subspan. ROIs shorter than 100 bp are absent from the 100 bp configs.

GAMBA's evaluator selects the 100 bp subspan using Python's process-randomized hash(). This release uses BLAKE2 over the same seed, category, and pair ID so the saved subset is stable across machines.

Configs

Config	Train rows	Test rows	Total	Pooling span
full	67,846	16,991	84,837	complete ROI
100bp	46,862	11,781	58,643	100 bp
full-noncoding-added	75,363	18,917	94,280	complete ROI
100bp-noncoding-added	54,028	13,595	67,623	100 bp

The two noncoding-added configs are explicit extensions from Gamba-Processing, not an additional category emitted by GAMBA's current create_eval_data.py.

Loading

from datasets import load_dataset

full = load_dataset(
    "Taykhoom/functional-multiclass-gamba",
    "full",
    split="all",
)
train = full.filter(lambda row: row["split"] == "train")
test = full.filter(lambda row: row["split"] == "test")

Here, split="all" tells Hugging Face to load the single physical parquet file. The parquet's own split column records the biological chromosome split (train or test). Keeping one file avoids duplicating the dataset; filter the column as shown above.

Columns

Column	Description
split, label	Probe/fine-tuning train or held-out test; label is the functional category.
sequence	Strand-oriented GAMBA context of at most 2,048 bp.
pair_id	Stable GAMBA feature/control identifier.
category, scope	Functional category and full or 100bp.
chrom, start, end, strand	Zero-based, half-open hg38 feature coordinates.
context_start, context_end	Forward-genome coordinates of sequence.
roi_start, roi_end	Full feature offsets within sequence.
pool_start, pool_end	Full-ROI or fixed 100 bp pooling span.
name	Source annotation name.
phylop_mean, phylop_std	Mean and population standard deviation over GAMBA's baseline ROI or fixed 100 bp span.
phylop_frac_pos, phylop_frac_neg	Fractions of pooled bases with positive or negative phyloP scores.
phylop_mean_pos, phylop_mean_neg	Means over positive or negative pooled scores, or zero when absent.
phylop_context_mean, phylop_context_std	Mean and population standard deviation over GAMBA's symmetric 2,048 bp phyloP context.
phylop_context_frac_pos, phylop_context_frac_neg	Fractions of context bases with positive or negative scores.
phylop_context_mean_pos, phylop_context_mean_neg	Means over positive or negative context scores, or zero when absent.

Data source and processing

The processing code reproduces the ten-category BED output from Microsoft GAMBA commit e83984e byte-for-byte, then freezes all GAMBA autosomes plus chrX in parquet. The GAMBA models were pretrained on the chromosomes marked train. The paper's zero-shot result used the frozen models on chr2, chr3, chr16, and chr22, which are marked test; no task-specific model was fitted on these benchmark rows. Use only test to reproduce that paper subset. The train rows are provided for probing/fine-tuning or broader chromosome evaluation.

PhyloP values come from the Zoonomia 241-mammalian track used by GAMBA. Uncovered positions are zero and scores are rounded to two decimal places before the float32 summaries are computed.

Citation

Please cite the GAMBA paper:

Consens, M. E. et al. Predicting evolutionary rate as a pretraining task improves genome language model representations. bioRxiv (2026). doi:10.64898/2026.02.02.703275. A conference version is available on OpenReview.

@article{consens2026predicting,
  title = {Predicting evolutionary rate as a pretraining task improves genome language model representations},
  author = {Consens, Micaela Elisa and Yang, Kevin K. and Hall, Jimmy and Conard, Ashley Mae and Wang, Bo and Crawford, Lorin and Moses, Alan and Lu, Alex X.},
  journal = {bioRxiv},
  year = {2026},
  doi = {10.64898/2026.02.02.703275},
  url = {https://doi.org/10.64898/2026.02.02.703275}
}

License

GAMBA and its released benchmark code/data are distributed under the MIT license. Upstream annotation resources retain their original terms.