id string | task_type string | pipeline string | difficulty string | num_hops int64 | question string | context string | reasoning_chain dict | answer string | choices list | modalities list | modality_data list | evidence list | metadata unknown | path_confidence_score float64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
co_evid_00055 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between USP8 and PTEN? | USP8 GENE_ENCODES_PROTEIN USP8 -> USP8 PROTEIN_PHYSICALLY_INTERACTS_WITH PTEN -> PTEN GENE_ENCODES_PROTEIN PTEN | {
"steps": [
{
"hop": 1,
"source_node_id": "USP8",
"source_node_type": "GENE",
"source_node_label": "USP8",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "9101",... | PMID:24270891 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PTEN",
"source_db": "UniProt",
"payload": {
"accession": "P60484",
"sequence": "MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVM... | [
{
"source_db": "bridge",
"source_id": "9101",
"text": "USP8 GENE_ENCODES_PROTEIN USP8",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5728",
"text": "USP8 PROTEIN_PHYSICALLY_INTERACTS_WITH PTEN",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"protein_a": "USP8",
"protein_b": "PTEN",
"pmid": "24270891",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00056 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between CAMK4 and HDAC4? | CAMK4 GENE_ENCODES_PROTEIN CAMK4 -> CAMK4 PROTEIN_PHYSICALLY_INTERACTS_WITH HDAC4 -> HDAC4 GENE_ENCODES_PROTEIN HDAC4 | {
"steps": [
{
"hop": 1,
"source_node_id": "CAMK4",
"source_node_type": "GENE",
"source_node_label": "CAMK4",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "814"... | PMID:11470791 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CAMK4",
"source_db": "UniProt",
"payload": {
"accession": "Q16566",
"sequence": "MLKVTVPSCSASSCSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEK... | [
{
"source_db": "bridge",
"source_id": "814",
"text": "CAMK4 GENE_ENCODES_PROTEIN CAMK4",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "9759",
"text": "CAMK4 PROTEIN_PHYSICALLY_INTERACTS_WITH HDAC4",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"protein_a": "CAMK4",
"protein_b": "HDAC4",
"pmid": "11470791",
"experiment": "Biochemical Activity"
} | 0.9 |
co_evid_00057 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between SOX2 and GAPDHS? | SOX2 GENE_ENCODES_PROTEIN SOX2 -> SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH GAPDHS -> GAPDHS GENE_ENCODES_PROTEIN GAPDHS | {
"steps": [
{
"hop": 1,
"source_node_id": "SOX2",
"source_node_type": "GENE",
"source_node_label": "SOX2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "6657",... | PMID:34732716 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SOX2",
"source_db": "UniProt",
"payload": {
"accession": "P48431",
"sequence": "MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAP... | [
{
"source_db": "bridge",
"source_id": "6657",
"text": "SOX2 GENE_ENCODES_PROTEIN SOX2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "26330",
"text": "SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH GAPDHS",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"protein_a": "SOX2",
"protein_b": "GAPDHS",
"pmid": "34732716",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00058 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between ATM and UCHL3? | ATM GENE_ENCODES_PROTEIN ATM -> ATM PROTEIN_PHYSICALLY_INTERACTS_WITH UCHL3 -> UCHL3 GENE_ENCODES_PROTEIN UCHL3 | {
"steps": [
{
"hop": 1,
"source_node_id": "ATM",
"source_node_type": "GENE",
"source_node_label": "ATM",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "472",
... | PMID:27941124 | null | [
"expression",
"protein_sequence"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ATM",
"source_db": "UniProt",
"payload": {
"accession": "Q13315",
"sequence": "MSLVLNDLLICCRQLEHDRATERKKEVEKFKRLIRDPETIKHLDRHSDSKQGKYLNWDAVFRFLQKYIQKETECLRIAKPNVSASTQASRQKKMQEISSLVKYFIKCANRRAPRLKCQELLNYIMDTVKDSSNGA... | [
{
"source_db": "bridge",
"source_id": "472",
"text": "ATM GENE_ENCODES_PROTEIN ATM",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7347",
"text": "ATM PROTEIN_PHYSICALLY_INTERACTS_WITH UCHL3",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "... | {
"protein_a": "ATM",
"protein_b": "UCHL3",
"pmid": "27941124",
"experiment": "Biochemical Activity"
} | 0.9 |
co_evid_00059 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between BARD1 and POLR2H? | BARD1 GENE_ENCODES_PROTEIN BARD1 -> BARD1 PROTEIN_PHYSICALLY_INTERACTS_WITH POLR2H -> POLR2H GENE_ENCODES_PROTEIN POLR2H | {
"steps": [
{
"hop": 1,
"source_node_id": "BARD1",
"source_node_type": "GENE",
"source_node_label": "BARD1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "580"... | PMID:17283126 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BARD1",
"source_db": "UniProt",
"payload": {
"accession": "Q99728",
"sequence": "MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREPVCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNELSDLKEDKPRKSLF... | [
{
"source_db": "bridge",
"source_id": "580",
"text": "BARD1 GENE_ENCODES_PROTEIN BARD1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5437",
"text": "BARD1 PROTEIN_PHYSICALLY_INTERACTS_WITH POLR2H",
"confidence": 0.9
},
{
"source_db": "bridge",
"source... | {
"protein_a": "BARD1",
"protein_b": "POLR2H",
"pmid": "17283126",
"experiment": "Biochemical Activity"
} | 0.9 |
co_evid_00060 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between LAMP1 and EGFR? | LAMP1 GENE_ENCODES_PROTEIN LAMP1 -> LAMP1 PROTEIN_PHYSICALLY_INTERACTS_WITH EGFR -> EGFR GENE_ENCODES_PROTEIN EGFR | {
"steps": [
{
"hop": 1,
"source_node_id": "LAMP1",
"source_node_type": "PROTEIN",
"source_node_label": "LAMP1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "3... | PMID:28986450 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "EGFR",
"source_db": "UniProt",
"payload": {
"accession": "P00533",
"sequence": "MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKE... | [
{
"source_db": "bridge",
"source_id": "3916",
"text": "LAMP1 GENE_ENCODES_PROTEIN LAMP1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1956",
"text": "LAMP1 PROTEIN_PHYSICALLY_INTERACTS_WITH EGFR",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"protein_a": "LAMP1",
"protein_b": "EGFR",
"pmid": "28986450",
"experiment": "Co-localization"
} | 0.9 |
co_evid_00061 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between USP11 and BRCA2? | USP11 GENE_ENCODES_PROTEIN USP11 -> USP11 PROTEIN_PHYSICALLY_INTERACTS_WITH BRCA2 -> BRCA2 GENE_ENCODES_PROTEIN BRCA2 | {
"steps": [
{
"hop": 1,
"source_node_id": "USP11",
"source_node_type": "GENE",
"source_node_label": "USP11",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "8237... | PMID:15314155 | null | [
"expression",
"protein_sequence"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BRCA2",
"source_db": "UniProt",
"payload": {
"accession": "P51587",
"sequence": "MPIGSKERPTFFEIFKTRCNKADLGPISLNWFEELSSEAPPYNSEPAEESEHKNNNYEPNLFKTPQRKPSYNQLASTPIIFKEQGLTLPLYQSPVKELDKFKLDLGRNVPNSRHKSLRTVKTKMDQADDVSCP... | [
{
"source_db": "bridge",
"source_id": "8237",
"text": "USP11 GENE_ENCODES_PROTEIN USP11",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "675",
"text": "USP11 PROTEIN_PHYSICALLY_INTERACTS_WITH BRCA2",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"protein_a": "USP11",
"protein_b": "BRCA2",
"pmid": "15314155",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00062 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between SOX2 and SPATS2? | SOX2 GENE_ENCODES_PROTEIN SOX2 -> SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH SPATS2 -> SPATS2 GENE_ENCODES_PROTEIN SPATS2 | {
"steps": [
{
"hop": 1,
"source_node_id": "SOX2",
"source_node_type": "GENE",
"source_node_label": "SOX2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "6657",... | PMID:34732716 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SOX2",
"source_db": "UniProt",
"payload": {
"accession": "P48431",
"sequence": "MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAP... | [
{
"source_db": "bridge",
"source_id": "6657",
"text": "SOX2 GENE_ENCODES_PROTEIN SOX2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "65244",
"text": "SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH SPATS2",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"protein_a": "SOX2",
"protein_b": "SPATS2",
"pmid": "34732716",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00063 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between TP53 and PPP2R1A? | TP53 GENE_ENCODES_PROTEIN TP53 -> TP53 PROTEIN_PHYSICALLY_INTERACTS_WITH PPP2R1A -> PPP2R1A GENE_ENCODES_PROTEIN PPP2R1A | {
"steps": [
{
"hop": 1,
"source_node_id": "TP53",
"source_node_type": "GENE",
"source_node_label": "TP53",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "7157",... | PMID:12665691 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "TP53",
"source_db": "UniProt",
"payload": {
"accession": "P04637",
"sequence": "MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMF... | [
{
"source_db": "bridge",
"source_id": "7157",
"text": "TP53 GENE_ENCODES_PROTEIN TP53",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5518",
"text": "TP53 PROTEIN_PHYSICALLY_INTERACTS_WITH PPP2R1A",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"protein_a": "TP53",
"protein_b": "PPP2R1A",
"pmid": "12665691",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00064 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between XPO1 and APC? | XPO1 GENE_ENCODES_PROTEIN XPO1 -> XPO1 PROTEIN_PHYSICALLY_INTERACTS_WITH APC -> APC GENE_ENCODES_PROTEIN APC | {
"steps": [
{
"hop": 1,
"source_node_id": "XPO1",
"source_node_type": "PROTEIN",
"source_node_label": "XPO1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "751... | PMID:12070164 | null | [
"expression",
"protein_sequence"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "APC",
"source_db": "UniProt",
"payload": {
"accession": "P25054",
"sequence": "MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSKMSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLE... | [
{
"source_db": "bridge",
"source_id": "7514",
"text": "XPO1 GENE_ENCODES_PROTEIN XPO1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "324",
"text": "XPO1 PROTEIN_PHYSICALLY_INTERACTS_WITH APC",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": ... | {
"protein_a": "XPO1",
"protein_b": "APC",
"pmid": "12070164",
"experiment": "Reconstituted Complex"
} | 0.9 |
co_evid_00065 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between CDK1 and SAMHD1? | CDK1 GENE_ENCODES_PROTEIN CDK1 -> CDK1 PROTEIN_PHYSICALLY_INTERACTS_WITH SAMHD1 -> SAMHD1 GENE_ENCODES_PROTEIN SAMHD1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CDK1",
"source_node_type": "GENE",
"source_node_label": "CDK1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "983",
... | PMID:27815502 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CDK1",
"source_db": "UniProt",
"payload": {
"accession": "P06493",
"sequence": "MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNL... | [
{
"source_db": "bridge",
"source_id": "983",
"text": "CDK1 GENE_ENCODES_PROTEIN CDK1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "25939",
"text": "CDK1 PROTEIN_PHYSICALLY_INTERACTS_WITH SAMHD1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"protein_a": "CDK1",
"protein_b": "SAMHD1",
"pmid": "27815502",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00066 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between CUL1 and ESR1? | CUL1 GENE_ENCODES_PROTEIN CUL1 -> CUL1 PROTEIN_PHYSICALLY_INTERACTS_WITH ESR1 -> ESR1 GENE_ENCODES_PROTEIN ESR1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CUL1",
"source_node_type": "PROTEIN",
"source_node_label": "CUL1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "845... | PMID:23770852 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ESR1",
"source_db": "UniProt",
"payload": {
"accession": "P03372",
"sequence": "MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLEN... | [
{
"source_db": "bridge",
"source_id": "8454",
"text": "CUL1 GENE_ENCODES_PROTEIN CUL1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "2099",
"text": "CUL1 PROTEIN_PHYSICALLY_INTERACTS_WITH ESR1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"protein_a": "CUL1",
"protein_b": "ESR1",
"pmid": "23770852",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00067 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between UBQLN2 and RPS27A? | UBQLN2 GENE_ENCODES_PROTEIN UBQLN2 -> UBQLN2 PROTEIN_PHYSICALLY_INTERACTS_WITH RPS27A -> RPS27A GENE_ENCODES_PROTEIN RPS27A | {
"steps": [
{
"hop": 1,
"source_node_id": "UBQLN2",
"source_node_type": "GENE",
"source_node_label": "UBQLN2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "29... | PMID:33277362 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "UBQLN2",
"source_db": "UniProt",
"payload": {
"accession": "Q9UHD9",
"sequence": "MAENGESSGPPRPSRGPAAAQGSAAAPAEPKIIKVTVKTPKEKEEFAVPENSSVQQFKEAISKRFKSQTDQLVLIFAGKILKDQDTLIQHGIHDGLTVHLVIKSQNRPQGQSTQPSNAAGTNTTSASTPRSN... | [
{
"source_db": "bridge",
"source_id": "29978",
"text": "UBQLN2 GENE_ENCODES_PROTEIN UBQLN2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "6233",
"text": "UBQLN2 PROTEIN_PHYSICALLY_INTERACTS_WITH RPS27A",
"confidence": 0.9
},
{
"source_db": "bridge",
"s... | {
"protein_a": "UBQLN2",
"protein_b": "RPS27A",
"pmid": "33277362",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00068 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between MAPK9 and MAPT? | MAPK9 GENE_ENCODES_PROTEIN MAPK9 -> MAPK9 PROTEIN_PHYSICALLY_INTERACTS_WITH MAPT -> MAPT GENE_ENCODES_PROTEIN MAPT | {
"steps": [
{
"hop": 1,
"source_node_id": "MAPK9",
"source_node_type": "GENE",
"source_node_label": "MAPK9",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "5601... | PMID:17906291 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MAPT",
"source_db": "UniProt",
"payload": {
"accession": "P10636",
"sequence": "MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQEPESGKVVQE... | [
{
"source_db": "bridge",
"source_id": "5601",
"text": "MAPK9 GENE_ENCODES_PROTEIN MAPK9",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "4137",
"text": "MAPK9 PROTEIN_PHYSICALLY_INTERACTS_WITH MAPT",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"protein_a": "MAPK9",
"protein_b": "MAPT",
"pmid": "17906291",
"experiment": "Biochemical Activity"
} | 0.9 |
co_evid_00069 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between ERBB2 and PTK2? | ERBB2 GENE_ENCODES_PROTEIN ERBB2 -> ERBB2 PROTEIN_PHYSICALLY_INTERACTS_WITH PTK2 -> PTK2 GENE_ENCODES_PROTEIN PTK2 | {
"steps": [
{
"hop": 1,
"source_node_id": "ERBB2",
"source_node_type": "GENE",
"source_node_label": "ERBB2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "2064... | PMID:12600989 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ERBB2",
"source_db": "UniProt",
"payload": {
"accession": "P04626",
"sequence": "MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGAS... | [
{
"source_db": "bridge",
"source_id": "2064",
"text": "ERBB2 GENE_ENCODES_PROTEIN ERBB2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5747",
"text": "ERBB2 PROTEIN_PHYSICALLY_INTERACTS_WITH PTK2",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"protein_a": "ERBB2",
"protein_b": "PTK2",
"pmid": "12600989",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00070 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between MYC and EP300? | MYC GENE_ENCODES_PROTEIN MYC -> MYC PROTEIN_PHYSICALLY_INTERACTS_WITH EP300 -> EP300 GENE_ENCODES_PROTEIN EP300 | {
"steps": [
{
"hop": 1,
"source_node_id": "MYC",
"source_node_type": "GENE",
"source_node_label": "MYC",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "4609",
... | PMID:16287840 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MYC",
"source_db": "UniProt",
"payload": {
"accession": "P01106",
"sequence": "MDFFRVVENQQPPATMPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPD... | [
{
"source_db": "bridge",
"source_id": "4609",
"text": "MYC GENE_ENCODES_PROTEIN MYC",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "2033",
"text": "MYC PROTEIN_PHYSICALLY_INTERACTS_WITH EP300",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": ... | {
"protein_a": "MYC",
"protein_b": "EP300",
"pmid": "16287840",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00071 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between NRAS and RPS20? | NRAS GENE_ENCODES_PROTEIN NRAS -> NRAS PROTEIN_PHYSICALLY_INTERACTS_WITH RPS20 -> RPS20 GENE_ENCODES_PROTEIN RPS20 | {
"steps": [
{
"hop": 1,
"source_node_id": "NRAS",
"source_node_type": "GENE",
"source_node_label": "NRAS",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "4893",... | PMID:18624398 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "NRAS",
"source_db": "UniProt",
"payload": {
"accession": "P01111",
"sequence": "MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELA... | [
{
"source_db": "bridge",
"source_id": "4893",
"text": "NRAS GENE_ENCODES_PROTEIN NRAS",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "6224",
"text": "NRAS PROTEIN_PHYSICALLY_INTERACTS_WITH RPS20",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"protein_a": "NRAS",
"protein_b": "RPS20",
"pmid": "18624398",
"experiment": "Two-hybrid"
} | 0.9 |
co_evid_00072 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between NOS3 and PSEN2? | NOS3 GENE_ENCODES_PROTEIN NOS3 -> NOS3 PROTEIN_PHYSICALLY_INTERACTS_WITH PSEN2 -> PSEN2 GENE_ENCODES_PROTEIN PSEN2 | {
"steps": [
{
"hop": 1,
"source_node_id": "NOS3",
"source_node_type": "GENE",
"source_node_label": "NOS3",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "4846",... | PMID:21163940 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PSEN2",
"source_db": "UniProt",
"payload": {
"accession": "P49810",
"sequence": "MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDPDRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQ... | [
{
"source_db": "bridge",
"source_id": "4846",
"text": "NOS3 GENE_ENCODES_PROTEIN NOS3",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5664",
"text": "NOS3 PROTEIN_PHYSICALLY_INTERACTS_WITH PSEN2",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"protein_a": "NOS3",
"protein_b": "PSEN2",
"pmid": "21163940",
"experiment": "Two-hybrid"
} | 0.9 |
co_evid_00073 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between CEBPA and VDR? | CEBPA GENE_ENCODES_PROTEIN CEBPA -> CEBPA PROTEIN_PHYSICALLY_INTERACTS_WITH VDR -> VDR GENE_ENCODES_PROTEIN VDR | {
"steps": [
{
"hop": 1,
"source_node_id": "CEBPA",
"source_node_type": "GENE",
"source_node_label": "CEBPA",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1050... | PMID:16357103 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CEBPA",
"source_db": "UniProt",
"payload": {
"accession": "P49715",
"sequence": "MESADFYEAEPRPPMSSHLQSPPHAPSSAAFGFPRGAGPAQPPAPPAAPEPLGGICEHETSIDISAYIDPAAFNDEFLADLFQHSRQQEKAKAAVGPTGGGGGGDFDYPGAPAGPGGAVMPGGAHGPPPGYGC... | [
{
"source_db": "bridge",
"source_id": "1050",
"text": "CEBPA GENE_ENCODES_PROTEIN CEBPA",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7421",
"text": "CEBPA PROTEIN_PHYSICALLY_INTERACTS_WITH VDR",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"protein_a": "CEBPA",
"protein_b": "VDR",
"pmid": "16357103",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00074 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between MDC1 and PTEN? | MDC1 GENE_ENCODES_PROTEIN MDC1 -> MDC1 PROTEIN_PHYSICALLY_INTERACTS_WITH PTEN -> PTEN GENE_ENCODES_PROTEIN PTEN | {
"steps": [
{
"hop": 1,
"source_node_id": "MDC1",
"source_node_type": "PROTEIN",
"source_node_label": "MDC1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "965... | PMID:31217297 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PTEN",
"source_db": "UniProt",
"payload": {
"accession": "P60484",
"sequence": "MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVM... | [
{
"source_db": "bridge",
"source_id": "9656",
"text": "MDC1 GENE_ENCODES_PROTEIN MDC1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5728",
"text": "MDC1 PROTEIN_PHYSICALLY_INTERACTS_WITH PTEN",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"protein_a": "MDC1",
"protein_b": "PTEN",
"pmid": "31217297",
"experiment": "Reconstituted Complex"
} | 0.9 |
co_evid_00075 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between BRCA1 and KPNA3? | BRCA1 GENE_ENCODES_PROTEIN BRCA1 -> BRCA1 PROTEIN_PHYSICALLY_INTERACTS_WITH KPNA3 -> KPNA3 GENE_ENCODES_PROTEIN KPNA3 | {
"steps": [
{
"hop": 1,
"source_node_id": "BRCA1",
"source_node_type": "GENE",
"source_node_label": "BRCA1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "672"... | PMID:34591612 | null | [
"expression",
"intercell_role",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BRCA1",
"source_db": "UniProt",
"payload": {
"accession": "P38398",
"sequence": "MDLSALRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNFAKKENNSPEHLKDEVSIIQSMGYRNR... | [
{
"source_db": "bridge",
"source_id": "672",
"text": "BRCA1 GENE_ENCODES_PROTEIN BRCA1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "3839",
"text": "BRCA1 PROTEIN_PHYSICALLY_INTERACTS_WITH KPNA3",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"protein_a": "BRCA1",
"protein_b": "KPNA3",
"pmid": "34591612",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00076 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between EGFR and GBF1? | EGFR GENE_ENCODES_PROTEIN EGFR -> EGFR PROTEIN_PHYSICALLY_INTERACTS_WITH GBF1 -> GBF1 GENE_ENCODES_PROTEIN GBF1 | {
"steps": [
{
"hop": 1,
"source_node_id": "EGFR",
"source_node_type": "GENE",
"source_node_label": "EGFR",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1956",... | PMID:23956138 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "EGFR",
"source_db": "UniProt",
"payload": {
"accession": "P00533",
"sequence": "MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKE... | [
{
"source_db": "bridge",
"source_id": "1956",
"text": "EGFR GENE_ENCODES_PROTEIN EGFR",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "8729",
"text": "EGFR PROTEIN_PHYSICALLY_INTERACTS_WITH GBF1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"protein_a": "EGFR",
"protein_b": "GBF1",
"pmid": "23956138",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00077 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between SQSTM1 and YWHAZ? | SQSTM1 GENE_ENCODES_PROTEIN SQSTM1 -> SQSTM1 PROTEIN_PHYSICALLY_INTERACTS_WITH YWHAZ -> YWHAZ GENE_ENCODES_PROTEIN YWHAZ | {
"steps": [
{
"hop": 1,
"source_node_id": "SQSTM1",
"source_node_type": "GENE",
"source_node_label": "SQSTM1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "88... | PMID:14702098 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SQSTM1",
"source_db": "UniProt",
"payload": {
"accession": "Q13501",
"sequence": "MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCN... | [
{
"source_db": "bridge",
"source_id": "8878",
"text": "SQSTM1 GENE_ENCODES_PROTEIN SQSTM1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7534",
"text": "SQSTM1 PROTEIN_PHYSICALLY_INTERACTS_WITH YWHAZ",
"confidence": 0.9
},
{
"source_db": "bridge",
"sou... | {
"protein_a": "SQSTM1",
"protein_b": "YWHAZ",
"pmid": "14702098",
"experiment": "Reconstituted Complex"
} | 0.9 |
co_evid_00078 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between NEK1 and C21orf2? | NEK1 GENE_ENCODES_PROTEIN NEK1 -> NEK1 PROTEIN_PHYSICALLY_INTERACTS_WITH C21orf2 -> C21orf2 GENE_ENCODES_PROTEIN C21orf2 | {
"steps": [
{
"hop": 1,
"source_node_id": "NEK1",
"source_node_type": "GENE",
"source_node_label": "NEK1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "4750",... | PMID:32891887 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "NEK1",
"source_db": "UniProt",
"payload": {
"accession": "Q96PY6",
"sequence": "MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNI... | [
{
"source_db": "bridge",
"source_id": "4750",
"text": "NEK1 GENE_ENCODES_PROTEIN NEK1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "755",
"text": "NEK1 PROTEIN_PHYSICALLY_INTERACTS_WITH C21orf2",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"protein_a": "NEK1",
"protein_b": "C21orf2",
"pmid": "32891887",
"experiment": "Biochemical Activity"
} | 0.9 |
co_evid_00079 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between LEPR and USP8? | LEPR GENE_ENCODES_PROTEIN LEPR -> LEPR PROTEIN_PHYSICALLY_INTERACTS_WITH USP8 -> USP8 GENE_ENCODES_PROTEIN USP8 | {
"steps": [
{
"hop": 1,
"source_node_id": "LEPR",
"source_node_type": "GENE",
"source_node_label": "LEPR",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "3953",... | PMID:31199479 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "LEPR",
"source_db": "UniProt",
"payload": {
"accession": "P48357",
"sequence": "MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLK... | [
{
"source_db": "bridge",
"source_id": "3953",
"text": "LEPR GENE_ENCODES_PROTEIN LEPR",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "9101",
"text": "LEPR PROTEIN_PHYSICALLY_INTERACTS_WITH USP8",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"protein_a": "LEPR",
"protein_b": "USP8",
"pmid": "31199479",
"experiment": "Proximity Label-MS"
} | 0.9 |
co_evid_00080 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between CEBPA and PARP1? | CEBPA GENE_ENCODES_PROTEIN CEBPA -> CEBPA PROTEIN_PHYSICALLY_INTERACTS_WITH PARP1 -> PARP1 GENE_ENCODES_PROTEIN PARP1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CEBPA",
"source_node_type": "GENE",
"source_node_label": "CEBPA",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1050... | PMID:16490787 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CEBPA",
"source_db": "UniProt",
"payload": {
"accession": "P49715",
"sequence": "MESADFYEAEPRPPMSSHLQSPPHAPSSAAFGFPRGAGPAQPPAPPAAPEPLGGICEHETSIDISAYIDPAAFNDEFLADLFQHSRQQEKAKAAVGPTGGGGGGDFDYPGAPAGPGGAVMPGGAHGPPPGYGC... | [
{
"source_db": "bridge",
"source_id": "1050",
"text": "CEBPA GENE_ENCODES_PROTEIN CEBPA",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "142",
"text": "CEBPA PROTEIN_PHYSICALLY_INTERACTS_WITH PARP1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"protein_a": "CEBPA",
"protein_b": "PARP1",
"pmid": "16490787",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00081 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between SQSTM1 and TRIM25? | SQSTM1 GENE_ENCODES_PROTEIN SQSTM1 -> SQSTM1 PROTEIN_PHYSICALLY_INTERACTS_WITH TRIM25 -> TRIM25 GENE_ENCODES_PROTEIN TRIM25 | {
"steps": [
{
"hop": 1,
"source_node_id": "SQSTM1",
"source_node_type": "GENE",
"source_node_label": "SQSTM1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "88... | PMID:34037656 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SQSTM1",
"source_db": "UniProt",
"payload": {
"accession": "Q13501",
"sequence": "MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCN... | [
{
"source_db": "bridge",
"source_id": "8878",
"text": "SQSTM1 GENE_ENCODES_PROTEIN SQSTM1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7706",
"text": "SQSTM1 PROTEIN_PHYSICALLY_INTERACTS_WITH TRIM25",
"confidence": 0.9
},
{
"source_db": "bridge",
"so... | {
"protein_a": "SQSTM1",
"protein_b": "TRIM25",
"pmid": "34037656",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00082 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between SPOP and GNB2L1? | SPOP GENE_ENCODES_PROTEIN SPOP -> SPOP PROTEIN_PHYSICALLY_INTERACTS_WITH GNB2L1 -> GNB2L1 GENE_ENCODES_PROTEIN GNB2L1 | {
"steps": [
{
"hop": 1,
"source_node_id": "SPOP",
"source_node_type": "GENE",
"source_node_label": "SPOP",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "8405",... | PMID:37442135 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SPOP",
"source_db": "UniProt",
"payload": {
"accession": "O43791",
"sequence": "MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFK... | [
{
"source_db": "bridge",
"source_id": "8405",
"text": "SPOP GENE_ENCODES_PROTEIN SPOP",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "10399",
"text": "SPOP PROTEIN_PHYSICALLY_INTERACTS_WITH GNB2L1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"protein_a": "SPOP",
"protein_b": "GNB2L1",
"pmid": "37442135",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00083 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between RICTOR and BRCA1? | RICTOR GENE_ENCODES_PROTEIN RICTOR -> RICTOR PROTEIN_PHYSICALLY_INTERACTS_WITH BRCA1 -> BRCA1 GENE_ENCODES_PROTEIN BRCA1 | {
"steps": [
{
"hop": 1,
"source_node_id": "RICTOR",
"source_node_type": "GENE",
"source_node_label": "RICTOR",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "25... | PMID:22990118 | null | [
"expression",
"intercell_role",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BRCA1",
"source_db": "UniProt",
"payload": {
"accession": "P38398",
"sequence": "MDLSALRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNFAKKENNSPEHLKDEVSIIQSMGYRNR... | [
{
"source_db": "bridge",
"source_id": "253260",
"text": "RICTOR GENE_ENCODES_PROTEIN RICTOR",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "672",
"text": "RICTOR PROTEIN_PHYSICALLY_INTERACTS_WITH BRCA1",
"confidence": 0.9
},
{
"source_db": "bridge",
"so... | {
"protein_a": "RICTOR",
"protein_b": "BRCA1",
"pmid": "22990118",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00084 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between ESR1 and POLR2I? | ESR1 GENE_ENCODES_PROTEIN ESR1 -> ESR1 PROTEIN_PHYSICALLY_INTERACTS_WITH POLR2I -> POLR2I GENE_ENCODES_PROTEIN POLR2I | {
"steps": [
{
"hop": 1,
"source_node_id": "ESR1",
"source_node_type": "GENE",
"source_node_label": "ESR1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "2099",... | PMID:16957778 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ESR1",
"source_db": "UniProt",
"payload": {
"accession": "P03372",
"sequence": "MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLEN... | [
{
"source_db": "bridge",
"source_id": "2099",
"text": "ESR1 GENE_ENCODES_PROTEIN ESR1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5438",
"text": "ESR1 PROTEIN_PHYSICALLY_INTERACTS_WITH POLR2I",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"protein_a": "ESR1",
"protein_b": "POLR2I",
"pmid": "16957778",
"experiment": "Co-localization"
} | 0.9 |
co_evid_00085 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between BRCA2 and RUVBL2? | BRCA2 GENE_ENCODES_PROTEIN BRCA2 -> BRCA2 PROTEIN_PHYSICALLY_INTERACTS_WITH RUVBL2 -> RUVBL2 GENE_ENCODES_PROTEIN RUVBL2 | {
"steps": [
{
"hop": 1,
"source_node_id": "BRCA2",
"source_node_type": "GENE",
"source_node_label": "BRCA2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "675"... | PMID:30686591 | null | [
"expression",
"protein_sequence"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BRCA2",
"source_db": "UniProt",
"payload": {
"accession": "P51587",
"sequence": "MPIGSKERPTFFEIFKTRCNKADLGPISLNWFEELSSEAPPYNSEPAEESEHKNNNYEPNLFKTPQRKPSYNQLASTPIIFKEQGLTLPLYQSPVKELDKFKLDLGRNVPNSRHKSLRTVKTKMDQADDVSCP... | [
{
"source_db": "bridge",
"source_id": "675",
"text": "BRCA2 GENE_ENCODES_PROTEIN BRCA2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "10856",
"text": "BRCA2 PROTEIN_PHYSICALLY_INTERACTS_WITH RUVBL2",
"confidence": 0.9
},
{
"source_db": "bridge",
"sourc... | {
"protein_a": "BRCA2",
"protein_b": "RUVBL2",
"pmid": "30686591",
"experiment": "Negative Genetic"
} | 0.9 |
co_evid_00086 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between USP49 and CTNNB1? | USP49 GENE_ENCODES_PROTEIN USP49 -> USP49 PROTEIN_PHYSICALLY_INTERACTS_WITH CTNNB1 -> CTNNB1 GENE_ENCODES_PROTEIN CTNNB1 | {
"steps": [
{
"hop": 1,
"source_node_id": "USP49",
"source_node_type": "GENE",
"source_node_label": "USP49",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "2586... | PMID:30323974 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CTNNB1",
"source_db": "UniProt",
"payload": {
"accession": "P35222",
"sequence": "MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQML... | [
{
"source_db": "bridge",
"source_id": "25862",
"text": "USP49 GENE_ENCODES_PROTEIN USP49",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1499",
"text": "USP49 PROTEIN_PHYSICALLY_INTERACTS_WITH CTNNB1",
"confidence": 0.9
},
{
"source_db": "bridge",
"sour... | {
"protein_a": "USP49",
"protein_b": "CTNNB1",
"pmid": "30323974",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00087 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between CCND1 and HDAC1? | CCND1 GENE_ENCODES_PROTEIN CCND1 -> CCND1 PROTEIN_PHYSICALLY_INTERACTS_WITH HDAC1 -> HDAC1 GENE_ENCODES_PROTEIN HDAC1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CCND1",
"source_node_type": "GENE",
"source_node_label": "CCND1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "595"... | PMID:15713663 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CCND1",
"source_db": "UniProt",
"payload": {
"accession": "P24385",
"sequence": "MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIR... | [
{
"source_db": "bridge",
"source_id": "595",
"text": "CCND1 GENE_ENCODES_PROTEIN CCND1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "3065",
"text": "CCND1 PROTEIN_PHYSICALLY_INTERACTS_WITH HDAC1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"protein_a": "CCND1",
"protein_b": "HDAC1",
"pmid": "15713663",
"experiment": "Co-localization"
} | 0.9 |
co_evid_00088 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between HAP1 and PCM1? | HAP1 GENE_ENCODES_PROTEIN HAP1 -> HAP1 PROTEIN_PHYSICALLY_INTERACTS_WITH PCM1 -> PCM1 GENE_ENCODES_PROTEIN PCM1 | {
"steps": [
{
"hop": 1,
"source_node_id": "HAP1",
"source_node_type": "GENE",
"source_node_label": "HAP1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "9001",... | PMID:9361024 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "HAP1",
"source_db": "UniProt",
"payload": {
"accession": "P54257",
"sequence": "MRPKRLGRCCAGSRLGPGDPAALTCAPSPSASPAPEPSAQPQARGTGQRVGSRATSGSQFLSEARTGARPASEAGAKAGARRPSAFSAIQGDVRSMPDNSDAPWTRFVFQGPFGSRATGRGTGKAAGIWKTPAA... | [
{
"source_db": "bridge",
"source_id": "9001",
"text": "HAP1 GENE_ENCODES_PROTEIN HAP1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5108",
"text": "HAP1 PROTEIN_PHYSICALLY_INTERACTS_WITH PCM1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"protein_a": "HAP1",
"protein_b": "PCM1",
"pmid": "9361024",
"experiment": "Two-hybrid"
} | 0.9 |
co_evid_00089 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between CTNNA1 and CDH5? | CTNNA1 GENE_ENCODES_PROTEIN CTNNA1 -> CTNNA1 PROTEIN_PHYSICALLY_INTERACTS_WITH CDH5 -> CDH5 GENE_ENCODES_PROTEIN CDH5 | {
"steps": [
{
"hop": 1,
"source_node_id": "CTNNA1",
"source_node_type": "GENE",
"source_node_label": "CTNNA1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "14... | PMID:33497368 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CTNNA1",
"source_db": "UniProt",
"payload": {
"accession": "P35221",
"sequence": "MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVKRGNMVRAARALL... | [
{
"source_db": "bridge",
"source_id": "1495",
"text": "CTNNA1 GENE_ENCODES_PROTEIN CTNNA1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1003",
"text": "CTNNA1 PROTEIN_PHYSICALLY_INTERACTS_WITH CDH5",
"confidence": 0.9
},
{
"source_db": "bridge",
"sour... | {
"protein_a": "CTNNA1",
"protein_b": "CDH5",
"pmid": "33497368",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00090 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between DERL1 and PSMA6? | DERL1 GENE_ENCODES_PROTEIN DERL1 -> DERL1 PROTEIN_PHYSICALLY_INTERACTS_WITH PSMA6 -> PSMA6 GENE_ENCODES_PROTEIN PSMA6 | {
"steps": [
{
"hop": 1,
"source_node_id": "DERL1",
"source_node_type": "PROTEIN",
"source_node_label": "DERL1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "7... | PMID:28137758 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PSMA6",
"source_db": "UniProt",
"payload": {
"accession": "P60900",
"sequence": "MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRP... | [
{
"source_db": "bridge",
"source_id": "79139",
"text": "DERL1 GENE_ENCODES_PROTEIN DERL1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5687",
"text": "DERL1 PROTEIN_PHYSICALLY_INTERACTS_WITH PSMA6",
"confidence": 0.9
},
{
"source_db": "bridge",
"sourc... | {
"protein_a": "DERL1",
"protein_b": "PSMA6",
"pmid": "28137758",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00091 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between NEK1 and KIF3A? | NEK1 GENE_ENCODES_PROTEIN NEK1 -> NEK1 PROTEIN_PHYSICALLY_INTERACTS_WITH KIF3A -> KIF3A GENE_ENCODES_PROTEIN KIF3A | {
"steps": [
{
"hop": 1,
"source_node_id": "NEK1",
"source_node_type": "GENE",
"source_node_label": "NEK1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "4750",... | PMID:14690447 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "NEK1",
"source_db": "UniProt",
"payload": {
"accession": "Q96PY6",
"sequence": "MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNI... | [
{
"source_db": "bridge",
"source_id": "4750",
"text": "NEK1 GENE_ENCODES_PROTEIN NEK1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "11127",
"text": "NEK1 PROTEIN_PHYSICALLY_INTERACTS_WITH KIF3A",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"protein_a": "NEK1",
"protein_b": "KIF3A",
"pmid": "14690447",
"experiment": "Two-hybrid"
} | 0.9 |
co_evid_00092 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between PMS2 and CLSPN? | PMS2 GENE_ENCODES_PROTEIN PMS2 -> PMS2 PROTEIN_PHYSICALLY_INTERACTS_WITH CLSPN -> CLSPN GENE_ENCODES_PROTEIN CLSPN | {
"steps": [
{
"hop": 1,
"source_node_id": "PMS2",
"source_node_type": "GENE",
"source_node_label": "PMS2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "5395",... | PMID:20029092 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PMS2",
"source_db": "UniProt",
"payload": {
"accession": "P54278",
"sequence": "MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTR... | [
{
"source_db": "bridge",
"source_id": "5395",
"text": "PMS2 GENE_ENCODES_PROTEIN PMS2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "63967",
"text": "PMS2 PROTEIN_PHYSICALLY_INTERACTS_WITH CLSPN",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"protein_a": "PMS2",
"protein_b": "CLSPN",
"pmid": "20029092",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00093 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between SOX2 and DCAF5? | SOX2 GENE_ENCODES_PROTEIN SOX2 -> SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH DCAF5 -> DCAF5 GENE_ENCODES_PROTEIN DCAF5 | {
"steps": [
{
"hop": 1,
"source_node_id": "SOX2",
"source_node_type": "GENE",
"source_node_label": "SOX2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "6657",... | PMID:30442713 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SOX2",
"source_db": "UniProt",
"payload": {
"accession": "P48431",
"sequence": "MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAP... | [
{
"source_db": "bridge",
"source_id": "6657",
"text": "SOX2 GENE_ENCODES_PROTEIN SOX2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "8816",
"text": "SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH DCAF5",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"protein_a": "SOX2",
"protein_b": "DCAF5",
"pmid": "30442713",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00094 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between ESR1 and CUL4B? | ESR1 GENE_ENCODES_PROTEIN ESR1 -> ESR1 PROTEIN_PHYSICALLY_INTERACTS_WITH CUL4B -> CUL4B GENE_ENCODES_PROTEIN CUL4B | {
"steps": [
{
"hop": 1,
"source_node_id": "ESR1",
"source_node_type": "GENE",
"source_node_label": "ESR1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "2099",... | PMID:17392787 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ESR1",
"source_db": "UniProt",
"payload": {
"accession": "P03372",
"sequence": "MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLEN... | [
{
"source_db": "bridge",
"source_id": "2099",
"text": "ESR1 GENE_ENCODES_PROTEIN ESR1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "8450",
"text": "ESR1 PROTEIN_PHYSICALLY_INTERACTS_WITH CUL4B",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"protein_a": "ESR1",
"protein_b": "CUL4B",
"pmid": "17392787",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00095 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between BRCA1 and CCNB1? | BRCA1 GENE_ENCODES_PROTEIN BRCA1 -> BRCA1 PROTEIN_PHYSICALLY_INTERACTS_WITH CCNB1 -> CCNB1 GENE_ENCODES_PROTEIN CCNB1 | {
"steps": [
{
"hop": 1,
"source_node_id": "BRCA1",
"source_node_type": "GENE",
"source_node_label": "BRCA1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "672"... | PMID:9244350 | null | [
"expression",
"intercell_role",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BRCA1",
"source_db": "UniProt",
"payload": {
"accession": "P38398",
"sequence": "MDLSALRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNFAKKENNSPEHLKDEVSIIQSMGYRNR... | [
{
"source_db": "bridge",
"source_id": "672",
"text": "BRCA1 GENE_ENCODES_PROTEIN BRCA1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "891",
"text": "BRCA1 PROTEIN_PHYSICALLY_INTERACTS_WITH CCNB1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"protein_a": "BRCA1",
"protein_b": "CCNB1",
"pmid": "9244350",
"experiment": "Reconstituted Complex"
} | 0.9 |
co_evid_00096 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between CDK1 and TFDP1? | CDK1 GENE_ENCODES_PROTEIN CDK1 -> CDK1 PROTEIN_PHYSICALLY_INTERACTS_WITH TFDP1 -> TFDP1 GENE_ENCODES_PROTEIN TFDP1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CDK1",
"source_node_type": "GENE",
"source_node_label": "CDK1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "983",
... | PMID:9199321 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CDK1",
"source_db": "UniProt",
"payload": {
"accession": "P06493",
"sequence": "MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNL... | [
{
"source_db": "bridge",
"source_id": "983",
"text": "CDK1 GENE_ENCODES_PROTEIN CDK1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7027",
"text": "CDK1 PROTEIN_PHYSICALLY_INTERACTS_WITH TFDP1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"protein_a": "CDK1",
"protein_b": "TFDP1",
"pmid": "9199321",
"experiment": "Biochemical Activity"
} | 0.9 |
co_evid_00097 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between C9orf72 and DDX11? | C9orf72 GENE_ENCODES_PROTEIN C9orf72 -> C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH DDX11 -> DDX11 GENE_ENCODES_PROTEIN DDX11 | {
"steps": [
{
"hop": 1,
"source_node_id": "C9orf72",
"source_node_type": "GENE",
"source_node_label": "C9orf72",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | PMID:37317656 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "C9orf72",
"source_db": "UniProt",
"payload": {
"accession": "Q96LT7",
"sequence": "MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVC... | [
{
"source_db": "bridge",
"source_id": "203228",
"text": "C9orf72 GENE_ENCODES_PROTEIN C9orf72",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1663",
"text": "C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH DDX11",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"protein_a": "C9orf72",
"protein_b": "DDX11",
"pmid": "37317656",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00098 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between CDK1 and CKS2? | CDK1 GENE_ENCODES_PROTEIN CDK1 -> CDK1 PROTEIN_PHYSICALLY_INTERACTS_WITH CKS2 -> CKS2 GENE_ENCODES_PROTEIN CKS2 | {
"steps": [
{
"hop": 1,
"source_node_id": "CDK1",
"source_node_type": "GENE",
"source_node_label": "CDK1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "983",
... | PMID:18471975 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CDK1",
"source_db": "UniProt",
"payload": {
"accession": "P06493",
"sequence": "MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNL... | [
{
"source_db": "bridge",
"source_id": "983",
"text": "CDK1 GENE_ENCODES_PROTEIN CDK1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1164",
"text": "CDK1 PROTEIN_PHYSICALLY_INTERACTS_WITH CKS2",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id":... | {
"protein_a": "CDK1",
"protein_b": "CKS2",
"pmid": "18471975",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00099 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between CPVL and ACTB? | CPVL GENE_ENCODES_PROTEIN CPVL -> CPVL PROTEIN_PHYSICALLY_INTERACTS_WITH ACTB -> ACTB GENE_ENCODES_PROTEIN ACTB | {
"steps": [
{
"hop": 1,
"source_node_id": "CPVL",
"source_node_type": "GENE",
"source_node_label": "CPVL",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "54504"... | PMID:34784299 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ACTB",
"source_db": "UniProt",
"payload": {
"accession": "P60709",
"sequence": "MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYV... | [
{
"source_db": "bridge",
"source_id": "54504",
"text": "CPVL GENE_ENCODES_PROTEIN CPVL",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "60",
"text": "CPVL PROTEIN_PHYSICALLY_INTERACTS_WITH ACTB",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id":... | {
"protein_a": "CPVL",
"protein_b": "ACTB",
"pmid": "34784299",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00100 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between PTPN1 and CTNNB1? | PTPN1 GENE_ENCODES_PROTEIN PTPN1 -> PTPN1 PROTEIN_PHYSICALLY_INTERACTS_WITH CTNNB1 -> CTNNB1 GENE_ENCODES_PROTEIN CTNNB1 | {
"steps": [
{
"hop": 1,
"source_node_id": "PTPN1",
"source_node_type": "GENE",
"source_node_label": "PTPN1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "5770... | PMID:12377785 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CTNNB1",
"source_db": "UniProt",
"payload": {
"accession": "P35222",
"sequence": "MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQML... | [
{
"source_db": "bridge",
"source_id": "5770",
"text": "PTPN1 GENE_ENCODES_PROTEIN PTPN1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1499",
"text": "PTPN1 PROTEIN_PHYSICALLY_INTERACTS_WITH CTNNB1",
"confidence": 0.9
},
{
"source_db": "bridge",
"sourc... | {
"protein_a": "PTPN1",
"protein_b": "CTNNB1",
"pmid": "12377785",
"experiment": "Reconstituted Complex"
} | 0.9 |
co_evid_00101 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between SMAD7 and TP53? | SMAD7 GENE_ENCODES_PROTEIN SMAD7 -> SMAD7 PROTEIN_PHYSICALLY_INTERACTS_WITH TP53 -> TP53 GENE_ENCODES_PROTEIN TP53 | {
"steps": [
{
"hop": 1,
"source_node_id": "SMAD7",
"source_node_type": "GENE",
"source_node_label": "SMAD7",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "4092... | PMID:17172861 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "TP53",
"source_db": "UniProt",
"payload": {
"accession": "P04637",
"sequence": "MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMF... | [
{
"source_db": "bridge",
"source_id": "4092",
"text": "SMAD7 GENE_ENCODES_PROTEIN SMAD7",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7157",
"text": "SMAD7 PROTEIN_PHYSICALLY_INTERACTS_WITH TP53",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"protein_a": "SMAD7",
"protein_b": "TP53",
"pmid": "17172861",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00102 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between PIK3CA and SGK1? | PIK3CA GENE_ENCODES_PROTEIN PIK3CA -> PIK3CA PROTEIN_PHYSICALLY_INTERACTS_WITH SGK1 -> SGK1 GENE_ENCODES_PROTEIN SGK1 | {
"steps": [
{
"hop": 1,
"source_node_id": "PIK3CA",
"source_node_type": "GENE",
"source_node_label": "PIK3CA",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "52... | PMID:10357815 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PIK3CA",
"source_db": "UniProt",
"payload": {
"accession": "P42336",
"sequence": "MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPVCEFDMVK... | [
{
"source_db": "bridge",
"source_id": "5290",
"text": "PIK3CA GENE_ENCODES_PROTEIN PIK3CA",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "6446",
"text": "PIK3CA PROTEIN_PHYSICALLY_INTERACTS_WITH SGK1",
"confidence": 0.9
},
{
"source_db": "bridge",
"sour... | {
"protein_a": "PIK3CA",
"protein_b": "SGK1",
"pmid": "10357815",
"experiment": "Reconstituted Complex"
} | 0.9 |
co_evid_00103 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between ZBTB2 and AURKB? | ZBTB2 GENE_ENCODES_PROTEIN ZBTB2 -> ZBTB2 PROTEIN_PHYSICALLY_INTERACTS_WITH AURKB -> AURKB GENE_ENCODES_PROTEIN AURKB | {
"steps": [
{
"hop": 1,
"source_node_id": "ZBTB2",
"source_node_type": "GENE",
"source_node_label": "ZBTB2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "5762... | PMID:33301849 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AURKB",
"source_db": "UniProt",
"payload": {
"accession": "Q96GD4",
"sequence": "MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLH... | [
{
"source_db": "bridge",
"source_id": "57621",
"text": "ZBTB2 GENE_ENCODES_PROTEIN ZBTB2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "9212",
"text": "ZBTB2 PROTEIN_PHYSICALLY_INTERACTS_WITH AURKB",
"confidence": 0.9
},
{
"source_db": "bridge",
"sourc... | {
"protein_a": "ZBTB2",
"protein_b": "AURKB",
"pmid": "33301849",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00104 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between RNF168 and BRCA2? | RNF168 GENE_ENCODES_PROTEIN RNF168 -> RNF168 PROTEIN_PHYSICALLY_INTERACTS_WITH BRCA2 -> BRCA2 GENE_ENCODES_PROTEIN BRCA2 | {
"steps": [
{
"hop": 1,
"source_node_id": "RNF168",
"source_node_type": "PROTEIN",
"source_node_label": "RNF168",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": ... | PMID:28240985 | null | [
"expression",
"protein_sequence"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BRCA2",
"source_db": "UniProt",
"payload": {
"accession": "P51587",
"sequence": "MPIGSKERPTFFEIFKTRCNKADLGPISLNWFEELSSEAPPYNSEPAEESEHKNNNYEPNLFKTPQRKPSYNQLASTPIIFKEQGLTLPLYQSPVKELDKFKLDLGRNVPNSRHKSLRTVKTKMDQADDVSCP... | [
{
"source_db": "bridge",
"source_id": "165918",
"text": "RNF168 GENE_ENCODES_PROTEIN RNF168",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "675",
"text": "RNF168 PROTEIN_PHYSICALLY_INTERACTS_WITH BRCA2",
"confidence": 0.9
},
{
"source_db": "bridge",
"so... | {
"protein_a": "RNF168",
"protein_b": "BRCA2",
"pmid": "28240985",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00105 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between RHOB and CTNNA1? | RHOB GENE_ENCODES_PROTEIN RHOB -> RHOB PROTEIN_PHYSICALLY_INTERACTS_WITH CTNNA1 -> CTNNA1 GENE_ENCODES_PROTEIN CTNNA1 | {
"steps": [
{
"hop": 1,
"source_node_id": "RHOB",
"source_node_type": "GENE",
"source_node_label": "RHOB",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "388",
... | PMID:31871319 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CTNNA1",
"source_db": "UniProt",
"payload": {
"accession": "P35221",
"sequence": "MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVKRGNMVRAARALL... | [
{
"source_db": "bridge",
"source_id": "388",
"text": "RHOB GENE_ENCODES_PROTEIN RHOB",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1495",
"text": "RHOB PROTEIN_PHYSICALLY_INTERACTS_WITH CTNNA1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"protein_a": "RHOB",
"protein_b": "CTNNA1",
"pmid": "31871319",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00106 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between GTF2H3 and AR? | GTF2H3 GENE_ENCODES_PROTEIN GTF2H3 -> GTF2H3 PROTEIN_PHYSICALLY_INTERACTS_WITH AR -> AR GENE_ENCODES_PROTEIN AR | {
"steps": [
{
"hop": 1,
"source_node_id": "GTF2H3",
"source_node_type": "PROTEIN",
"source_node_label": "GTF2H3",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": ... | PMID:21157430 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AR",
"source_db": "UniProt",
"payload": {
"accession": "P10275",
"sequence": "MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQQQQQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSALECHPERGCVPEPG... | [
{
"source_db": "bridge",
"source_id": "2967",
"text": "GTF2H3 GENE_ENCODES_PROTEIN GTF2H3",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "367",
"text": "GTF2H3 PROTEIN_PHYSICALLY_INTERACTS_WITH AR",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"protein_a": "GTF2H3",
"protein_b": "AR",
"pmid": "21157430",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00107 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between TOM1 and OPTN? | TOM1 GENE_ENCODES_PROTEIN TOM1 -> TOM1 PROTEIN_PHYSICALLY_INTERACTS_WITH OPTN -> OPTN GENE_ENCODES_PROTEIN OPTN | {
"steps": [
{
"hop": 1,
"source_node_id": "TOM1",
"source_node_type": "GENE",
"source_node_label": "TOM1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "10043"... | PMID:31371777 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "OPTN",
"source_db": "UniProt",
"payload": {
"accession": "Q96CV9",
"sequence": "MSHQPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRA... | [
{
"source_db": "bridge",
"source_id": "10043",
"text": "TOM1 GENE_ENCODES_PROTEIN TOM1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "10133",
"text": "TOM1 PROTEIN_PHYSICALLY_INTERACTS_WITH OPTN",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"protein_a": "TOM1",
"protein_b": "OPTN",
"pmid": "31371777",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00108 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between OTUD3 and PTEN? | OTUD3 GENE_ENCODES_PROTEIN OTUD3 -> OTUD3 PROTEIN_PHYSICALLY_INTERACTS_WITH PTEN -> PTEN GENE_ENCODES_PROTEIN PTEN | {
"steps": [
{
"hop": 1,
"source_node_id": "OTUD3",
"source_node_type": "GENE",
"source_node_label": "OTUD3",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "2325... | PMID:26280536 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PTEN",
"source_db": "UniProt",
"payload": {
"accession": "P60484",
"sequence": "MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVM... | [
{
"source_db": "bridge",
"source_id": "23252",
"text": "OTUD3 GENE_ENCODES_PROTEIN OTUD3",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5728",
"text": "OTUD3 PROTEIN_PHYSICALLY_INTERACTS_WITH PTEN",
"confidence": 0.9
},
{
"source_db": "bridge",
"source... | {
"protein_a": "OTUD3",
"protein_b": "PTEN",
"pmid": "26280536",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00109 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between TP53 and LNX1? | TP53 GENE_ENCODES_PROTEIN TP53 -> TP53 PROTEIN_PHYSICALLY_INTERACTS_WITH LNX1 -> LNX1 GENE_ENCODES_PROTEIN LNX1 | {
"steps": [
{
"hop": 1,
"source_node_id": "TP53",
"source_node_type": "GENE",
"source_node_label": "TP53",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "7157",... | PMID:31533005 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "TP53",
"source_db": "UniProt",
"payload": {
"accession": "P04637",
"sequence": "MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMF... | [
{
"source_db": "bridge",
"source_id": "7157",
"text": "TP53 GENE_ENCODES_PROTEIN TP53",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "84708",
"text": "TP53 PROTEIN_PHYSICALLY_INTERACTS_WITH LNX1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"protein_a": "TP53",
"protein_b": "LNX1",
"pmid": "31533005",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00110 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between TP53 and PSMC3? | TP53 GENE_ENCODES_PROTEIN TP53 -> TP53 PROTEIN_PHYSICALLY_INTERACTS_WITH PSMC3 -> PSMC3 GENE_ENCODES_PROTEIN PSMC3 | {
"steps": [
{
"hop": 1,
"source_node_id": "TP53",
"source_node_type": "GENE",
"source_node_label": "TP53",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "7157",... | PMID:30862715 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "TP53",
"source_db": "UniProt",
"payload": {
"accession": "P04637",
"sequence": "MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMF... | [
{
"source_db": "bridge",
"source_id": "7157",
"text": "TP53 GENE_ENCODES_PROTEIN TP53",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5702",
"text": "TP53 PROTEIN_PHYSICALLY_INTERACTS_WITH PSMC3",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"protein_a": "TP53",
"protein_b": "PSMC3",
"pmid": "30862715",
"experiment": "Negative Genetic"
} | 0.9 |
co_evid_00111 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between AKT2 and APPL1? | AKT2 GENE_ENCODES_PROTEIN AKT2 -> AKT2 PROTEIN_PHYSICALLY_INTERACTS_WITH APPL1 -> APPL1 GENE_ENCODES_PROTEIN APPL1 | {
"steps": [
{
"hop": 1,
"source_node_id": "AKT2",
"source_node_type": "GENE",
"source_node_label": "AKT2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "208",
... | PMID:10490823 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AKT2",
"source_db": "UniProt",
"payload": {
"accession": "P31751",
"sequence": "MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTE... | [
{
"source_db": "bridge",
"source_id": "208",
"text": "AKT2 GENE_ENCODES_PROTEIN AKT2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "26060",
"text": "AKT2 PROTEIN_PHYSICALLY_INTERACTS_WITH APPL1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"protein_a": "AKT2",
"protein_b": "APPL1",
"pmid": "10490823",
"experiment": "Two-hybrid"
} | 0.9 |
co_evid_00112 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between UBQLN2 and HSPA1B? | UBQLN2 GENE_ENCODES_PROTEIN UBQLN2 -> UBQLN2 PROTEIN_PHYSICALLY_INTERACTS_WITH HSPA1B -> HSPA1B GENE_ENCODES_PROTEIN HSPA1B | {
"steps": [
{
"hop": 1,
"source_node_id": "UBQLN2",
"source_node_type": "GENE",
"source_node_label": "UBQLN2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "29... | PMID:27477512 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "UBQLN2",
"source_db": "UniProt",
"payload": {
"accession": "Q9UHD9",
"sequence": "MAENGESSGPPRPSRGPAAAQGSAAAPAEPKIIKVTVKTPKEKEEFAVPENSSVQQFKEAISKRFKSQTDQLVLIFAGKILKDQDTLIQHGIHDGLTVHLVIKSQNRPQGQSTQPSNAAGTNTTSASTPRSN... | [
{
"source_db": "bridge",
"source_id": "29978",
"text": "UBQLN2 GENE_ENCODES_PROTEIN UBQLN2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "3304",
"text": "UBQLN2 PROTEIN_PHYSICALLY_INTERACTS_WITH HSPA1B",
"confidence": 0.9
},
{
"source_db": "bridge",
"s... | {
"protein_a": "UBQLN2",
"protein_b": "HSPA1B",
"pmid": "27477512",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00113 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between BBC3 and BAX? | BBC3 GENE_ENCODES_PROTEIN BBC3 -> BBC3 PROTEIN_PHYSICALLY_INTERACTS_WITH BAX -> BAX GENE_ENCODES_PROTEIN BAX | {
"steps": [
{
"hop": 1,
"source_node_id": "BBC3",
"source_node_type": "GENE",
"source_node_label": "BBC3",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "27113"... | PMID:34587475 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BAX",
"source_db": "UniProt",
"payload": {
"accession": "Q07812",
"sequence": "MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSNMELQRMIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKVPELIRT... | [
{
"source_db": "bridge",
"source_id": "27113",
"text": "BBC3 GENE_ENCODES_PROTEIN BBC3",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "581",
"text": "BBC3 PROTEIN_PHYSICALLY_INTERACTS_WITH BAX",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id":... | {
"protein_a": "BBC3",
"protein_b": "BAX",
"pmid": "34587475",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00114 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between C9orf72 and HIST1H2AB? | C9orf72 GENE_ENCODES_PROTEIN C9orf72 -> C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH HIST1H2AB -> HIST1H2AB GENE_ENCODES_PROTEIN HIST1H2AB | {
"steps": [
{
"hop": 1,
"source_node_id": "C9orf72",
"source_node_type": "GENE",
"source_node_label": "C9orf72",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | PMID:37317656 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "C9orf72",
"source_db": "UniProt",
"payload": {
"accession": "Q96LT7",
"sequence": "MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVC... | [
{
"source_db": "bridge",
"source_id": "203228",
"text": "C9orf72 GENE_ENCODES_PROTEIN C9orf72",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "8335",
"text": "C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH HIST1H2AB",
"confidence": 0.9
},
{
"source_db": "bridge",... | {
"protein_a": "C9orf72",
"protein_b": "HIST1H2AB",
"pmid": "37317656",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00115 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between RAC2 and KRAS? | RAC2 GENE_ENCODES_PROTEIN RAC2 -> RAC2 PROTEIN_PHYSICALLY_INTERACTS_WITH KRAS -> KRAS GENE_ENCODES_PROTEIN KRAS | {
"steps": [
{
"hop": 1,
"source_node_id": "RAC2",
"source_node_type": "PROTEIN",
"source_node_label": "RAC2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "588... | PMID:31871319 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "KRAS",
"source_db": "UniProt",
"payload": {
"accession": "P01116",
"sequence": "MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLA... | [
{
"source_db": "bridge",
"source_id": "5880",
"text": "RAC2 GENE_ENCODES_PROTEIN RAC2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "3845",
"text": "RAC2 PROTEIN_PHYSICALLY_INTERACTS_WITH KRAS",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"protein_a": "RAC2",
"protein_b": "KRAS",
"pmid": "31871319",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00116 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between CTNNB1 and RUVBL1? | CTNNB1 GENE_ENCODES_PROTEIN CTNNB1 -> CTNNB1 PROTEIN_PHYSICALLY_INTERACTS_WITH RUVBL1 -> RUVBL1 GENE_ENCODES_PROTEIN RUVBL1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CTNNB1",
"source_node_type": "GENE",
"source_node_label": "CTNNB1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "14... | PMID:9843967 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CTNNB1",
"source_db": "UniProt",
"payload": {
"accession": "P35222",
"sequence": "MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQML... | [
{
"source_db": "bridge",
"source_id": "1499",
"text": "CTNNB1 GENE_ENCODES_PROTEIN CTNNB1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "8607",
"text": "CTNNB1 PROTEIN_PHYSICALLY_INTERACTS_WITH RUVBL1",
"confidence": 0.9
},
{
"source_db": "bridge",
"so... | {
"protein_a": "CTNNB1",
"protein_b": "RUVBL1",
"pmid": "9843967",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00117 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between CREBBP and COPS2? | CREBBP GENE_ENCODES_PROTEIN CREBBP -> CREBBP PROTEIN_PHYSICALLY_INTERACTS_WITH COPS2 -> COPS2 GENE_ENCODES_PROTEIN COPS2 | {
"steps": [
{
"hop": 1,
"source_node_id": "CREBBP",
"source_node_type": "GENE",
"source_node_label": "CREBBP",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "13... | PMID:23441852 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CREBBP",
"source_db": "UniProt",
"payload": {
"accession": "Q92793",
"sequence": "MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPS... | [
{
"source_db": "bridge",
"source_id": "1387",
"text": "CREBBP GENE_ENCODES_PROTEIN CREBBP",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "9318",
"text": "CREBBP PROTEIN_PHYSICALLY_INTERACTS_WITH COPS2",
"confidence": 0.9
},
{
"source_db": "bridge",
"sou... | {
"protein_a": "CREBBP",
"protein_b": "COPS2",
"pmid": "23441852",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00118 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between BARD1 and AURKB? | BARD1 GENE_ENCODES_PROTEIN BARD1 -> BARD1 PROTEIN_PHYSICALLY_INTERACTS_WITH AURKB -> AURKB GENE_ENCODES_PROTEIN AURKB | {
"steps": [
{
"hop": 1,
"source_node_id": "BARD1",
"source_node_type": "GENE",
"source_node_label": "BARD1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "580"... | PMID:19176389 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BARD1",
"source_db": "UniProt",
"payload": {
"accession": "Q99728",
"sequence": "MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREPVCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNELSDLKEDKPRKSLF... | [
{
"source_db": "bridge",
"source_id": "580",
"text": "BARD1 GENE_ENCODES_PROTEIN BARD1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "9212",
"text": "BARD1 PROTEIN_PHYSICALLY_INTERACTS_WITH AURKB",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"protein_a": "BARD1",
"protein_b": "AURKB",
"pmid": "19176389",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00119 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between RPS6KB1 and TBK1? | RPS6KB1 GENE_ENCODES_PROTEIN RPS6KB1 -> RPS6KB1 PROTEIN_PHYSICALLY_INTERACTS_WITH TBK1 -> TBK1 GENE_ENCODES_PROTEIN TBK1 | {
"steps": [
{
"hop": 1,
"source_node_id": "RPS6KB1",
"source_node_type": "PROTEIN",
"source_node_label": "RPS6KB1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id"... | PMID:28716898 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "TBK1",
"source_db": "UniProt",
"payload": {
"accession": "Q9UHD2",
"sequence": "MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR... | [
{
"source_db": "bridge",
"source_id": "6198",
"text": "RPS6KB1 GENE_ENCODES_PROTEIN RPS6KB1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "29110",
"text": "RPS6KB1 PROTEIN_PHYSICALLY_INTERACTS_WITH TBK1",
"confidence": 0.9
},
{
"source_db": "bridge",
"... | {
"protein_a": "RPS6KB1",
"protein_b": "TBK1",
"pmid": "28716898",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00120 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between BLM and TEP1? | BLM GENE_ENCODES_PROTEIN BLM -> BLM PROTEIN_PHYSICALLY_INTERACTS_WITH TEP1 -> TEP1 GENE_ENCODES_PROTEIN TEP1 | {
"steps": [
{
"hop": 1,
"source_node_id": "BLM",
"source_node_type": "GENE",
"source_node_label": "BLM",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "641",
... | PMID:19329795 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BLM",
"source_db": "UniProt",
"payload": {
"accession": "P54132",
"sequence": "MAAVPQNNLQEQLERHSARTLNNKLSLSKPKFSGFTFKKKTSSDNNVSVTNVSVAKTPVLRNKDVNVTEDFSFSEPLPNTTNQQRVKDFFKNAPAGQETQRGGSKSLLPDFLQTPKEVVCTTQNTPTVKKSRDTA... | [
{
"source_db": "bridge",
"source_id": "641",
"text": "BLM GENE_ENCODES_PROTEIN BLM",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7011",
"text": "BLM PROTEIN_PHYSICALLY_INTERACTS_WITH TEP1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "T... | {
"protein_a": "BLM",
"protein_b": "TEP1",
"pmid": "19329795",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00121 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between CBL and HIST1H2BB? | CBL GENE_ENCODES_PROTEIN CBL -> CBL PROTEIN_PHYSICALLY_INTERACTS_WITH HIST1H2BB -> HIST1H2BB GENE_ENCODES_PROTEIN HIST1H2BB | {
"steps": [
{
"hop": 1,
"source_node_id": "CBL",
"source_node_type": "GENE",
"source_node_label": "CBL",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "867",
... | PMID:36470425 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CBL",
"source_db": "UniProt",
"payload": {
"accession": "P22681",
"sequence": "MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKE... | [
{
"source_db": "bridge",
"source_id": "867",
"text": "CBL GENE_ENCODES_PROTEIN CBL",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "3018",
"text": "CBL PROTEIN_PHYSICALLY_INTERACTS_WITH HIST1H2BB",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"protein_a": "CBL",
"protein_b": "HIST1H2BB",
"pmid": "36470425",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00122 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between TSPYL2 and CREBBP? | TSPYL2 GENE_ENCODES_PROTEIN TSPYL2 -> TSPYL2 PROTEIN_PHYSICALLY_INTERACTS_WITH CREBBP -> CREBBP GENE_ENCODES_PROTEIN CREBBP | {
"steps": [
{
"hop": 1,
"source_node_id": "TSPYL2",
"source_node_type": "GENE",
"source_node_label": "TSPYL2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "64... | PMID:24413569 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CREBBP",
"source_db": "UniProt",
"payload": {
"accession": "Q92793",
"sequence": "MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPS... | [
{
"source_db": "bridge",
"source_id": "64061",
"text": "TSPYL2 GENE_ENCODES_PROTEIN TSPYL2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1387",
"text": "TSPYL2 PROTEIN_PHYSICALLY_INTERACTS_WITH CREBBP",
"confidence": 0.9
},
{
"source_db": "bridge",
"s... | {
"protein_a": "TSPYL2",
"protein_b": "CREBBP",
"pmid": "24413569",
"experiment": "Two-hybrid"
} | 0.9 |
co_evid_00123 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between XRN1 and ATXN2? | XRN1 GENE_ENCODES_PROTEIN XRN1 -> XRN1 PROTEIN_PHYSICALLY_INTERACTS_WITH ATXN2 -> ATXN2 GENE_ENCODES_PROTEIN ATXN2 | {
"steps": [
{
"hop": 1,
"source_node_id": "XRN1",
"source_node_type": "GENE",
"source_node_label": "XRN1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "54464"... | PMID:29395067 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ATXN2",
"source_db": "UniProt",
"payload": {
"accession": "Q99700",
"sequence": "MRSAAAAPRSPAVATESRRFAAARWPGWRSLQRPARRSGRGGGGAAPGPYPSAAPPPPGPGPPPSRQSSPPSASDCFGSNGNGGGAFRPGSRRLLGLGGPPRPFVVLLLPLASPGAPPAAPTRASPLGARASP... | [
{
"source_db": "bridge",
"source_id": "54464",
"text": "XRN1 GENE_ENCODES_PROTEIN XRN1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "6311",
"text": "XRN1 PROTEIN_PHYSICALLY_INTERACTS_WITH ATXN2",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"protein_a": "XRN1",
"protein_b": "ATXN2",
"pmid": "29395067",
"experiment": "Proximity Label-MS"
} | 0.9 |
co_evid_00124 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between MYC and PRPF6? | MYC GENE_ENCODES_PROTEIN MYC -> MYC PROTEIN_PHYSICALLY_INTERACTS_WITH PRPF6 -> PRPF6 GENE_ENCODES_PROTEIN PRPF6 | {
"steps": [
{
"hop": 1,
"source_node_id": "MYC",
"source_node_type": "GENE",
"source_node_label": "MYC",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "4609",
... | PMID:21150319 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MYC",
"source_db": "UniProt",
"payload": {
"accession": "P01106",
"sequence": "MDFFRVVENQQPPATMPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPD... | [
{
"source_db": "bridge",
"source_id": "4609",
"text": "MYC GENE_ENCODES_PROTEIN MYC",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "24148",
"text": "MYC PROTEIN_PHYSICALLY_INTERACTS_WITH PRPF6",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id":... | {
"protein_a": "MYC",
"protein_b": "PRPF6",
"pmid": "21150319",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00125 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between EGFR and SNRPD1? | EGFR GENE_ENCODES_PROTEIN EGFR -> EGFR PROTEIN_PHYSICALLY_INTERACTS_WITH SNRPD1 -> SNRPD1 GENE_ENCODES_PROTEIN SNRPD1 | {
"steps": [
{
"hop": 1,
"source_node_id": "EGFR",
"source_node_type": "GENE",
"source_node_label": "EGFR",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1956",... | PMID:23956138 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "EGFR",
"source_db": "UniProt",
"payload": {
"accession": "P00533",
"sequence": "MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKE... | [
{
"source_db": "bridge",
"source_id": "1956",
"text": "EGFR GENE_ENCODES_PROTEIN EGFR",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "6632",
"text": "EGFR PROTEIN_PHYSICALLY_INTERACTS_WITH SNRPD1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"protein_a": "EGFR",
"protein_b": "SNRPD1",
"pmid": "23956138",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00126 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between CDK1 and BCL2L1? | CDK1 GENE_ENCODES_PROTEIN CDK1 -> CDK1 PROTEIN_PHYSICALLY_INTERACTS_WITH BCL2L1 -> BCL2L1 GENE_ENCODES_PROTEIN BCL2L1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CDK1",
"source_node_type": "GENE",
"source_node_label": "CDK1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "983",
... | PMID:22617334 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CDK1",
"source_db": "UniProt",
"payload": {
"accession": "P06493",
"sequence": "MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNL... | [
{
"source_db": "bridge",
"source_id": "983",
"text": "CDK1 GENE_ENCODES_PROTEIN CDK1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "598",
"text": "CDK1 PROTEIN_PHYSICALLY_INTERACTS_WITH BCL2L1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"protein_a": "CDK1",
"protein_b": "BCL2L1",
"pmid": "22617334",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00127 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between CDC27 and CDH1? | CDC27 GENE_ENCODES_PROTEIN CDC27 -> CDC27 PROTEIN_PHYSICALLY_INTERACTS_WITH CDH1 -> CDH1 GENE_ENCODES_PROTEIN CDH1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CDC27",
"source_node_type": "GENE",
"source_node_label": "CDC27",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "996"... | PMID:22539978 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CDH1",
"source_db": "UniProt",
"payload": {
"accession": "P12830",
"sequence": "MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQASVSG... | [
{
"source_db": "bridge",
"source_id": "996",
"text": "CDC27 GENE_ENCODES_PROTEIN CDC27",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "999",
"text": "CDC27 PROTEIN_PHYSICALLY_INTERACTS_WITH CDH1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"protein_a": "CDC27",
"protein_b": "CDH1",
"pmid": "22539978",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00128 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between AXIN1 and APC? | AXIN1 GENE_ENCODES_PROTEIN AXIN1 -> AXIN1 PROTEIN_PHYSICALLY_INTERACTS_WITH APC -> APC GENE_ENCODES_PROTEIN APC | {
"steps": [
{
"hop": 1,
"source_node_id": "AXIN1",
"source_node_type": "PROTEIN",
"source_node_label": "AXIN1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "8... | PMID:9734785 | null | [
"expression",
"protein_sequence"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "APC",
"source_db": "UniProt",
"payload": {
"accession": "P25054",
"sequence": "MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSKMSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLE... | [
{
"source_db": "bridge",
"source_id": "8312",
"text": "AXIN1 GENE_ENCODES_PROTEIN AXIN1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "324",
"text": "AXIN1 PROTEIN_PHYSICALLY_INTERACTS_WITH APC",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"protein_a": "AXIN1",
"protein_b": "APC",
"pmid": "9734785",
"experiment": "Reconstituted Complex"
} | 0.9 |
co_evid_00129 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between BLM and TOP2A? | BLM GENE_ENCODES_PROTEIN BLM -> BLM PROTEIN_PHYSICALLY_INTERACTS_WITH TOP2A -> TOP2A GENE_ENCODES_PROTEIN TOP2A | {
"steps": [
{
"hop": 1,
"source_node_id": "BLM",
"source_node_type": "GENE",
"source_node_label": "BLM",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "641",
... | PMID:19329795 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BLM",
"source_db": "UniProt",
"payload": {
"accession": "P54132",
"sequence": "MAAVPQNNLQEQLERHSARTLNNKLSLSKPKFSGFTFKKKTSSDNNVSVTNVSVAKTPVLRNKDVNVTEDFSFSEPLPNTTNQQRVKDFFKNAPAGQETQRGGSKSLLPDFLQTPKEVVCTTQNTPTVKKSRDTA... | [
{
"source_db": "bridge",
"source_id": "641",
"text": "BLM GENE_ENCODES_PROTEIN BLM",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7153",
"text": "BLM PROTEIN_PHYSICALLY_INTERACTS_WITH TOP2A",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "... | {
"protein_a": "BLM",
"protein_b": "TOP2A",
"pmid": "19329795",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00130 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between ACTB and PAK4? | ACTB GENE_ENCODES_PROTEIN ACTB -> ACTB PROTEIN_PHYSICALLY_INTERACTS_WITH PAK4 -> PAK4 GENE_ENCODES_PROTEIN PAK4 | {
"steps": [
{
"hop": 1,
"source_node_id": "ACTB",
"source_node_type": "GENE",
"source_node_label": "ACTB",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "60",
... | PMID:19778628 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ACTB",
"source_db": "UniProt",
"payload": {
"accession": "P60709",
"sequence": "MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYV... | [
{
"source_db": "bridge",
"source_id": "60",
"text": "ACTB GENE_ENCODES_PROTEIN ACTB",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "10298",
"text": "ACTB PROTEIN_PHYSICALLY_INTERACTS_WITH PAK4",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id":... | {
"protein_a": "ACTB",
"protein_b": "PAK4",
"pmid": "19778628",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00131 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between C9orf72 and ETFA? | C9orf72 GENE_ENCODES_PROTEIN C9orf72 -> C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH ETFA -> ETFA GENE_ENCODES_PROTEIN ETFA | {
"steps": [
{
"hop": 1,
"source_node_id": "C9orf72",
"source_node_type": "GENE",
"source_node_label": "C9orf72",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | PMID:37317656 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "C9orf72",
"source_db": "UniProt",
"payload": {
"accession": "Q96LT7",
"sequence": "MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVC... | [
{
"source_db": "bridge",
"source_id": "203228",
"text": "C9orf72 GENE_ENCODES_PROTEIN C9orf72",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "2108",
"text": "C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH ETFA",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"protein_a": "C9orf72",
"protein_b": "ETFA",
"pmid": "37317656",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00132 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between SQSTM1 and NOD1? | SQSTM1 GENE_ENCODES_PROTEIN SQSTM1 -> SQSTM1 PROTEIN_PHYSICALLY_INTERACTS_WITH NOD1 -> NOD1 GENE_ENCODES_PROTEIN NOD1 | {
"steps": [
{
"hop": 1,
"source_node_id": "SQSTM1",
"source_node_type": "GENE",
"source_node_label": "SQSTM1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "88... | PMID:36221902 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SQSTM1",
"source_db": "UniProt",
"payload": {
"accession": "Q13501",
"sequence": "MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCN... | [
{
"source_db": "bridge",
"source_id": "8878",
"text": "SQSTM1 GENE_ENCODES_PROTEIN SQSTM1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "10392",
"text": "SQSTM1 PROTEIN_PHYSICALLY_INTERACTS_WITH NOD1",
"confidence": 0.9
},
{
"source_db": "bridge",
"sou... | {
"protein_a": "SQSTM1",
"protein_b": "NOD1",
"pmid": "36221902",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00133 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between BRCA1 and HIST2H2AC? | BRCA1 GENE_ENCODES_PROTEIN BRCA1 -> BRCA1 PROTEIN_PHYSICALLY_INTERACTS_WITH HIST2H2AC -> HIST2H2AC GENE_ENCODES_PROTEIN HIST2H2AC | {
"steps": [
{
"hop": 1,
"source_node_id": "BRCA1",
"source_node_type": "GENE",
"source_node_label": "BRCA1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "672"... | PMID:11927591 | null | [
"expression",
"intercell_role",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BRCA1",
"source_db": "UniProt",
"payload": {
"accession": "P38398",
"sequence": "MDLSALRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNFAKKENNSPEHLKDEVSIIQSMGYRNR... | [
{
"source_db": "bridge",
"source_id": "672",
"text": "BRCA1 GENE_ENCODES_PROTEIN BRCA1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "8338",
"text": "BRCA1 PROTEIN_PHYSICALLY_INTERACTS_WITH HIST2H2AC",
"confidence": 0.9
},
{
"source_db": "bridge",
"sou... | {
"protein_a": "BRCA1",
"protein_b": "HIST2H2AC",
"pmid": "11927591",
"experiment": "Biochemical Activity"
} | 0.9 |
co_evid_00134 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between ERBB2 and SHC1? | ERBB2 GENE_ENCODES_PROTEIN ERBB2 -> ERBB2 PROTEIN_PHYSICALLY_INTERACTS_WITH SHC1 -> SHC1 GENE_ENCODES_PROTEIN SHC1 | {
"steps": [
{
"hop": 1,
"source_node_id": "ERBB2",
"source_node_type": "GENE",
"source_node_label": "ERBB2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "2064... | PMID:16729043 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ERBB2",
"source_db": "UniProt",
"payload": {
"accession": "P04626",
"sequence": "MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGAS... | [
{
"source_db": "bridge",
"source_id": "2064",
"text": "ERBB2 GENE_ENCODES_PROTEIN ERBB2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "6464",
"text": "ERBB2 PROTEIN_PHYSICALLY_INTERACTS_WITH SHC1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"protein_a": "ERBB2",
"protein_b": "SHC1",
"pmid": "16729043",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00135 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between AXL and RANBP9? | AXL GENE_ENCODES_PROTEIN AXL -> AXL PROTEIN_PHYSICALLY_INTERACTS_WITH RANBP9 -> RANBP9 GENE_ENCODES_PROTEIN RANBP9 | {
"steps": [
{
"hop": 1,
"source_node_id": "AXL",
"source_node_type": "GENE",
"source_node_label": "AXL",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "558",
... | PMID:15964779 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AXL",
"source_db": "UniProt",
"payload": {
"accession": "P30530",
"sequence": "MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGL... | [
{
"source_db": "bridge",
"source_id": "558",
"text": "AXL GENE_ENCODES_PROTEIN AXL",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "10048",
"text": "AXL PROTEIN_PHYSICALLY_INTERACTS_WITH RANBP9",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id":... | {
"protein_a": "AXL",
"protein_b": "RANBP9",
"pmid": "15964779",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00136 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between CA9 and IPO5? | CA9 GENE_ENCODES_PROTEIN CA9 -> CA9 PROTEIN_PHYSICALLY_INTERACTS_WITH IPO5 -> IPO5 GENE_ENCODES_PROTEIN IPO5 | {
"steps": [
{
"hop": 1,
"source_node_id": "CA9",
"source_node_type": "GENE",
"source_node_label": "CA9",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "768",
... | PMID:23181366 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CA9",
"source_db": "UniProt",
"payload": {
"accession": "Q16790",
"sequence": "MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPLGEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPGDPQEPQNNAHRDKEG... | [
{
"source_db": "bridge",
"source_id": "768",
"text": "CA9 GENE_ENCODES_PROTEIN CA9",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "3843",
"text": "CA9 PROTEIN_PHYSICALLY_INTERACTS_WITH IPO5",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "I... | {
"protein_a": "CA9",
"protein_b": "IPO5",
"pmid": "23181366",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00137 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between KLF5 and ESR1? | KLF5 GENE_ENCODES_PROTEIN KLF5 -> KLF5 PROTEIN_PHYSICALLY_INTERACTS_WITH ESR1 -> ESR1 GENE_ENCODES_PROTEIN ESR1 | {
"steps": [
{
"hop": 1,
"source_node_id": "KLF5",
"source_node_type": "GENE",
"source_node_label": "KLF5",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "688",
... | PMID:19569049 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ESR1",
"source_db": "UniProt",
"payload": {
"accession": "P03372",
"sequence": "MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLEN... | [
{
"source_db": "bridge",
"source_id": "688",
"text": "KLF5 GENE_ENCODES_PROTEIN KLF5",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "2099",
"text": "KLF5 PROTEIN_PHYSICALLY_INTERACTS_WITH ESR1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id":... | {
"protein_a": "KLF5",
"protein_b": "ESR1",
"pmid": "19569049",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00138 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between CEBPA and CHD1? | CEBPA GENE_ENCODES_PROTEIN CEBPA -> CEBPA PROTEIN_PHYSICALLY_INTERACTS_WITH CHD1 -> CHD1 GENE_ENCODES_PROTEIN CHD1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CEBPA",
"source_node_type": "GENE",
"source_node_label": "CEBPA",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1050... | PMID:18817785 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CEBPA",
"source_db": "UniProt",
"payload": {
"accession": "P49715",
"sequence": "MESADFYEAEPRPPMSSHLQSPPHAPSSAAFGFPRGAGPAQPPAPPAAPEPLGGICEHETSIDISAYIDPAAFNDEFLADLFQHSRQQEKAKAAVGPTGGGGGGDFDYPGAPAGPGGAVMPGGAHGPPPGYGC... | [
{
"source_db": "bridge",
"source_id": "1050",
"text": "CEBPA GENE_ENCODES_PROTEIN CEBPA",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1105",
"text": "CEBPA PROTEIN_PHYSICALLY_INTERACTS_WITH CHD1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"protein_a": "CEBPA",
"protein_b": "CHD1",
"pmid": "18817785",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00139 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between VCP and TFRC? | VCP GENE_ENCODES_PROTEIN VCP -> VCP PROTEIN_PHYSICALLY_INTERACTS_WITH TFRC -> TFRC GENE_ENCODES_PROTEIN TFRC | {
"steps": [
{
"hop": 1,
"source_node_id": "VCP",
"source_node_type": "GENE",
"source_node_label": "VCP",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "7415",
... | PMID:35562734 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "VCP",
"source_db": "UniProt",
"payload": {
"accession": "P55072",
"sequence": "MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYL... | [
{
"source_db": "bridge",
"source_id": "7415",
"text": "VCP GENE_ENCODES_PROTEIN VCP",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7037",
"text": "VCP PROTEIN_PHYSICALLY_INTERACTS_WITH TFRC",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "... | {
"protein_a": "VCP",
"protein_b": "TFRC",
"pmid": "35562734",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00140 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between FLT3 and CBL? | FLT3 GENE_ENCODES_PROTEIN FLT3 -> FLT3 PROTEIN_PHYSICALLY_INTERACTS_WITH CBL -> CBL GENE_ENCODES_PROTEIN CBL | {
"steps": [
{
"hop": 1,
"source_node_id": "FLT3",
"source_node_type": "GENE",
"source_node_label": "FLT3",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "2322",... | PMID:17446348 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "FLT3",
"source_db": "UniProt",
"payload": {
"accession": "P36888",
"sequence": "MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMT... | [
{
"source_db": "bridge",
"source_id": "2322",
"text": "FLT3 GENE_ENCODES_PROTEIN FLT3",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "867",
"text": "FLT3 PROTEIN_PHYSICALLY_INTERACTS_WITH CBL",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": ... | {
"protein_a": "FLT3",
"protein_b": "CBL",
"pmid": "17446348",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00141 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between SKP2 and CDKN1A? | SKP2 GENE_ENCODES_PROTEIN SKP2 -> SKP2 PROTEIN_PHYSICALLY_INTERACTS_WITH CDKN1A -> CDKN1A GENE_ENCODES_PROTEIN CDKN1A | {
"steps": [
{
"hop": 1,
"source_node_id": "SKP2",
"source_node_type": "GENE",
"source_node_label": "SKP2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "6502",... | PMID:17679094 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CDKN1A",
"source_db": "UniProt",
"payload": {
"accession": "P38936",
"sequence": "MSEPAGDVRQNPCGSKACRRLFGPVDSEQLSRDCDALMAGCIQEARERWNFDFVTETPLEGDFAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTAEEDHVDLSLSCTLVPRSGEQAEGSPG... | [
{
"source_db": "bridge",
"source_id": "6502",
"text": "SKP2 GENE_ENCODES_PROTEIN SKP2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1026",
"text": "SKP2 PROTEIN_PHYSICALLY_INTERACTS_WITH CDKN1A",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"protein_a": "SKP2",
"protein_b": "CDKN1A",
"pmid": "17679094",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00142 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between ACVR1 and ACVR1? | ACVR1 GENE_ENCODES_PROTEIN ACVR1 -> ACVR1 PROTEIN_PHYSICALLY_INTERACTS_WITH ACVR1 -> ACVR1 GENE_ENCODES_PROTEIN ACVR1 | {
"steps": [
{
"hop": 1,
"source_node_id": "ACVR1",
"source_node_type": "GENE",
"source_node_label": "ACVR1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "90",... | PMID:18436533 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ACVR1",
"source_db": "UniProt",
"payload": {
"accession": "Q04771",
"sequence": "MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLIILSVVF... | [
{
"source_db": "bridge",
"source_id": "90",
"text": "ACVR1 GENE_ENCODES_PROTEIN ACVR1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "90",
"text": "ACVR1 PROTEIN_PHYSICALLY_INTERACTS_WITH ACVR1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"protein_a": "ACVR1",
"protein_b": "ACVR1",
"pmid": "18436533",
"experiment": "FRET"
} | 0.9 |
co_evid_00143 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between C9orf72 and AASDHPPT? | C9orf72 GENE_ENCODES_PROTEIN C9orf72 -> C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH AASDHPPT -> AASDHPPT GENE_ENCODES_PROTEIN AASDHPPT | {
"steps": [
{
"hop": 1,
"source_node_id": "C9orf72",
"source_node_type": "GENE",
"source_node_label": "C9orf72",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | PMID:37317656 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "C9orf72",
"source_db": "UniProt",
"payload": {
"accession": "Q96LT7",
"sequence": "MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVC... | [
{
"source_db": "bridge",
"source_id": "203228",
"text": "C9orf72 GENE_ENCODES_PROTEIN C9orf72",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "60496",
"text": "C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH AASDHPPT",
"confidence": 0.9
},
{
"source_db": "bridge",... | {
"protein_a": "C9orf72",
"protein_b": "AASDHPPT",
"pmid": "37317656",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00144 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between ESR1 and DYX1C1? | ESR1 GENE_ENCODES_PROTEIN ESR1 -> ESR1 PROTEIN_PHYSICALLY_INTERACTS_WITH DYX1C1 -> DYX1C1 GENE_ENCODES_PROTEIN DYX1C1 | {
"steps": [
{
"hop": 1,
"source_node_id": "ESR1",
"source_node_type": "GENE",
"source_node_label": "ESR1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "2099",... | PMID:19423554 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ESR1",
"source_db": "UniProt",
"payload": {
"accession": "P03372",
"sequence": "MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLEN... | [
{
"source_db": "bridge",
"source_id": "2099",
"text": "ESR1 GENE_ENCODES_PROTEIN ESR1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "161582",
"text": "ESR1 PROTEIN_PHYSICALLY_INTERACTS_WITH DYX1C1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source... | {
"protein_a": "ESR1",
"protein_b": "DYX1C1",
"pmid": "19423554",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00145 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between VCP and CTSD? | VCP GENE_ENCODES_PROTEIN VCP -> VCP PROTEIN_PHYSICALLY_INTERACTS_WITH CTSD -> CTSD GENE_ENCODES_PROTEIN CTSD | {
"steps": [
{
"hop": 1,
"source_node_id": "VCP",
"source_node_type": "GENE",
"source_node_label": "VCP",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "7415",
... | PMID:35562734 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "VCP",
"source_db": "UniProt",
"payload": {
"accession": "P55072",
"sequence": "MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYL... | [
{
"source_db": "bridge",
"source_id": "7415",
"text": "VCP GENE_ENCODES_PROTEIN VCP",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1509",
"text": "VCP PROTEIN_PHYSICALLY_INTERACTS_WITH CTSD",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "... | {
"protein_a": "VCP",
"protein_b": "CTSD",
"pmid": "35562734",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00146 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between RET and DUSP26? | RET GENE_ENCODES_PROTEIN RET -> RET PROTEIN_PHYSICALLY_INTERACTS_WITH DUSP26 -> DUSP26 GENE_ENCODES_PROTEIN DUSP26 | {
"steps": [
{
"hop": 1,
"source_node_id": "RET",
"source_node_type": "GENE",
"source_node_label": "RET",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "5979",
... | PMID:28065597 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "RET",
"source_db": "UniProt",
"payload": {
"accession": "P07949",
"sequence": "MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREG... | [
{
"source_db": "bridge",
"source_id": "5979",
"text": "RET GENE_ENCODES_PROTEIN RET",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "78986",
"text": "RET PROTEIN_PHYSICALLY_INTERACTS_WITH DUSP26",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"protein_a": "RET",
"protein_b": "DUSP26",
"pmid": "28065597",
"experiment": "Two-hybrid"
} | 0.9 |
co_evid_00147 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between WIPI2 and VCP? | WIPI2 GENE_ENCODES_PROTEIN WIPI2 -> WIPI2 PROTEIN_PHYSICALLY_INTERACTS_WITH VCP -> VCP GENE_ENCODES_PROTEIN VCP | {
"steps": [
{
"hop": 1,
"source_node_id": "WIPI2",
"source_node_type": "GENE",
"source_node_label": "WIPI2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "2610... | PMID:35389758 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "VCP",
"source_db": "UniProt",
"payload": {
"accession": "P55072",
"sequence": "MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYL... | [
{
"source_db": "bridge",
"source_id": "26100",
"text": "WIPI2 GENE_ENCODES_PROTEIN WIPI2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7415",
"text": "WIPI2 PROTEIN_PHYSICALLY_INTERACTS_WITH VCP",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"protein_a": "WIPI2",
"protein_b": "VCP",
"pmid": "35389758",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00148 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between RHOJ and ACVR1B? | RHOJ GENE_ENCODES_PROTEIN RHOJ -> RHOJ PROTEIN_PHYSICALLY_INTERACTS_WITH ACVR1B -> ACVR1B GENE_ENCODES_PROTEIN ACVR1B | {
"steps": [
{
"hop": 1,
"source_node_id": "RHOJ",
"source_node_type": "GENE",
"source_node_label": "RHOJ",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "57381"... | PMID:31871319 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ACVR1B",
"source_db": "UniProt",
"payload": {
"accession": "P36896",
"sequence": "MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIA... | [
{
"source_db": "bridge",
"source_id": "57381",
"text": "RHOJ GENE_ENCODES_PROTEIN RHOJ",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "91",
"text": "RHOJ PROTEIN_PHYSICALLY_INTERACTS_WITH ACVR1B",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"protein_a": "RHOJ",
"protein_b": "ACVR1B",
"pmid": "31871319",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00149 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between UBQLN2 and G3BP1? | UBQLN2 GENE_ENCODES_PROTEIN UBQLN2 -> UBQLN2 PROTEIN_PHYSICALLY_INTERACTS_WITH G3BP1 -> G3BP1 GENE_ENCODES_PROTEIN G3BP1 | {
"steps": [
{
"hop": 1,
"source_node_id": "UBQLN2",
"source_node_type": "GENE",
"source_node_label": "UBQLN2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "29... | PMID:30442662 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "UBQLN2",
"source_db": "UniProt",
"payload": {
"accession": "Q9UHD9",
"sequence": "MAENGESSGPPRPSRGPAAAQGSAAAPAEPKIIKVTVKTPKEKEEFAVPENSSVQQFKEAISKRFKSQTDQLVLIFAGKILKDQDTLIQHGIHDGLTVHLVIKSQNRPQGQSTQPSNAAGTNTTSASTPRSN... | [
{
"source_db": "bridge",
"source_id": "29978",
"text": "UBQLN2 GENE_ENCODES_PROTEIN UBQLN2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "10146",
"text": "UBQLN2 PROTEIN_PHYSICALLY_INTERACTS_WITH G3BP1",
"confidence": 0.9
},
{
"source_db": "bridge",
"s... | {
"protein_a": "UBQLN2",
"protein_b": "G3BP1",
"pmid": "30442662",
"experiment": "Co-localization"
} | 0.9 |
co_evid_00150 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between FBXW11 and PPP2R1B? | FBXW11 GENE_ENCODES_PROTEIN FBXW11 -> FBXW11 PROTEIN_PHYSICALLY_INTERACTS_WITH PPP2R1B -> PPP2R1B GENE_ENCODES_PROTEIN PPP2R1B | {
"steps": [
{
"hop": 1,
"source_node_id": "FBXW11",
"source_node_type": "PROTEIN",
"source_node_label": "FBXW11",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": ... | PMID:23555304 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PPP2R1B",
"source_db": "UniProt",
"payload": {
"accession": "P30154",
"sequence": "MAGASELGTGPGAAGGDGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGNFTGLVGGPDFAHCLLPPLENLATVEETVVRDKAVESLRQISQEH... | [
{
"source_db": "bridge",
"source_id": "23291",
"text": "FBXW11 GENE_ENCODES_PROTEIN FBXW11",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5519",
"text": "FBXW11 PROTEIN_PHYSICALLY_INTERACTS_WITH PPP2R1B",
"confidence": 0.9
},
{
"source_db": "bridge",
"... | {
"protein_a": "FBXW11",
"protein_b": "PPP2R1B",
"pmid": "23555304",
"experiment": "Two-hybrid"
} | 0.9 |
co_evid_00151 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between SLC9A3R1 and MYC? | SLC9A3R1 GENE_ENCODES_PROTEIN SLC9A3R1 -> SLC9A3R1 PROTEIN_PHYSICALLY_INTERACTS_WITH MYC -> MYC GENE_ENCODES_PROTEIN MYC | {
"steps": [
{
"hop": 1,
"source_node_id": "SLC9A3R1",
"source_node_type": "GENE",
"source_node_label": "SLC9A3R1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id":... | PMID:22466651 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MYC",
"source_db": "UniProt",
"payload": {
"accession": "P01106",
"sequence": "MDFFRVVENQQPPATMPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPD... | [
{
"source_db": "bridge",
"source_id": "9368",
"text": "SLC9A3R1 GENE_ENCODES_PROTEIN SLC9A3R1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "4609",
"text": "SLC9A3R1 PROTEIN_PHYSICALLY_INTERACTS_WITH MYC",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"protein_a": "SLC9A3R1",
"protein_b": "MYC",
"pmid": "22466651",
"experiment": "Co-localization"
} | 0.9 |
co_evid_00152 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between SOX2 and TFAM? | SOX2 GENE_ENCODES_PROTEIN SOX2 -> SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH TFAM -> TFAM GENE_ENCODES_PROTEIN TFAM | {
"steps": [
{
"hop": 1,
"source_node_id": "SOX2",
"source_node_type": "GENE",
"source_node_label": "SOX2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "6657",... | PMID:34732716 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SOX2",
"source_db": "UniProt",
"payload": {
"accession": "P48431",
"sequence": "MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAP... | [
{
"source_db": "bridge",
"source_id": "6657",
"text": "SOX2 GENE_ENCODES_PROTEIN SOX2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7019",
"text": "SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH TFAM",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"protein_a": "SOX2",
"protein_b": "TFAM",
"pmid": "34732716",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00153 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between MYC and SMTN? | MYC GENE_ENCODES_PROTEIN MYC -> MYC PROTEIN_PHYSICALLY_INTERACTS_WITH SMTN -> SMTN GENE_ENCODES_PROTEIN SMTN | {
"steps": [
{
"hop": 1,
"source_node_id": "MYC",
"source_node_type": "GENE",
"source_node_label": "MYC",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "4609",
... | PMID:21150319 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MYC",
"source_db": "UniProt",
"payload": {
"accession": "P01106",
"sequence": "MDFFRVVENQQPPATMPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPD... | [
{
"source_db": "bridge",
"source_id": "4609",
"text": "MYC GENE_ENCODES_PROTEIN MYC",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "6525",
"text": "MYC PROTEIN_PHYSICALLY_INTERACTS_WITH SMTN",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "... | {
"protein_a": "MYC",
"protein_b": "SMTN",
"pmid": "21150319",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00154 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between RHOA and CD44? | RHOA GENE_ENCODES_PROTEIN RHOA -> RHOA PROTEIN_PHYSICALLY_INTERACTS_WITH CD44 -> CD44 GENE_ENCODES_PROTEIN CD44 | {
"steps": [
{
"hop": 1,
"source_node_id": "RHOA",
"source_node_type": "GENE",
"source_node_label": "RHOA",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "387",
... | PMID:31871319 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CD44",
"source_db": "UniProt",
"payload": {
"accession": "P16070",
"sequence": "MDKFWWHAAWGLCLVPLSLAQIDLNITCRFAGVFHVEKNGRYSISRTEAADLCKAFNSTLPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCFNASAPPEEDCTSVTD... | [
{
"source_db": "bridge",
"source_id": "387",
"text": "RHOA GENE_ENCODES_PROTEIN RHOA",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "960",
"text": "RHOA PROTEIN_PHYSICALLY_INTERACTS_WITH CD44",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": ... | {
"protein_a": "RHOA",
"protein_b": "CD44",
"pmid": "31871319",
"experiment": "Affinity Capture-MS"
} | 0.9 |
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