id string | task_type string | pipeline string | difficulty string | num_hops int64 | question string | context string | reasoning_chain dict | answer string | choices list | modalities list | modality_data list | evidence list | metadata unknown | path_confidence_score float64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
co_evid_00155 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between CFTR and VCP? | CFTR GENE_ENCODES_PROTEIN CFTR -> CFTR PROTEIN_PHYSICALLY_INTERACTS_WITH VCP -> VCP GENE_ENCODES_PROTEIN VCP | {
"steps": [
{
"hop": 1,
"source_node_id": "CFTR",
"source_node_type": "GENE",
"source_node_label": "CFTR",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1080",... | PMID:16621797 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "VCP",
"source_db": "UniProt",
"payload": {
"accession": "P55072",
"sequence": "MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYL... | [
{
"source_db": "bridge",
"source_id": "1080",
"text": "CFTR GENE_ENCODES_PROTEIN CFTR",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7415",
"text": "CFTR PROTEIN_PHYSICALLY_INTERACTS_WITH VCP",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id":... | {
"protein_a": "CFTR",
"protein_b": "VCP",
"pmid": "16621797",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00156 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between GRM5 and APP? | GRM5 GENE_ENCODES_PROTEIN GRM5 -> GRM5 PROTEIN_PHYSICALLY_INTERACTS_WITH APP -> APP GENE_ENCODES_PROTEIN APP | {
"steps": [
{
"hop": 1,
"source_node_id": "GRM5",
"source_node_type": "PROTEIN",
"source_node_label": "GRM5",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "291... | PMID:30214040 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "APP",
"source_db": "UniProt",
"payload": {
"accession": "P05067",
"sequence": "MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKF... | [
{
"source_db": "bridge",
"source_id": "2915",
"text": "GRM5 GENE_ENCODES_PROTEIN GRM5",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "351",
"text": "GRM5 PROTEIN_PHYSICALLY_INTERACTS_WITH APP",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": ... | {
"protein_a": "GRM5",
"protein_b": "APP",
"pmid": "30214040",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00157 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between CTDSPL2 and CDK1? | CTDSPL2 GENE_ENCODES_PROTEIN CTDSPL2 -> CTDSPL2 PROTEIN_PHYSICALLY_INTERACTS_WITH CDK1 -> CDK1 GENE_ENCODES_PROTEIN CDK1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CTDSPL2",
"source_node_type": "GENE",
"source_node_label": "CTDSPL2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | PMID:26674342 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CDK1",
"source_db": "UniProt",
"payload": {
"accession": "P06493",
"sequence": "MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNL... | [
{
"source_db": "bridge",
"source_id": "51496",
"text": "CTDSPL2 GENE_ENCODES_PROTEIN CTDSPL2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "983",
"text": "CTDSPL2 PROTEIN_PHYSICALLY_INTERACTS_WITH CDK1",
"confidence": 0.9
},
{
"source_db": "bridge",
"s... | {
"protein_a": "CTDSPL2",
"protein_b": "CDK1",
"pmid": "26674342",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00158 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between AR and HDAC2? | AR GENE_ENCODES_PROTEIN AR -> AR PROTEIN_PHYSICALLY_INTERACTS_WITH HDAC2 -> HDAC2 GENE_ENCODES_PROTEIN HDAC2 | {
"steps": [
{
"hop": 1,
"source_node_id": "AR",
"source_node_type": "GENE",
"source_node_label": "AR",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "367",
... | PMID:34585037 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AR",
"source_db": "UniProt",
"payload": {
"accession": "P10275",
"sequence": "MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQQQQQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSALECHPERGCVPEPG... | [
{
"source_db": "bridge",
"source_id": "367",
"text": "AR GENE_ENCODES_PROTEIN AR",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "3066",
"text": "AR PROTEIN_PHYSICALLY_INTERACTS_WITH HDAC2",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "HDA... | {
"protein_a": "AR",
"protein_b": "HDAC2",
"pmid": "34585037",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00159 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between ABL1 and NFAT5? | ABL1 GENE_ENCODES_PROTEIN ABL1 -> ABL1 PROTEIN_PHYSICALLY_INTERACTS_WITH NFAT5 -> NFAT5 GENE_ENCODES_PROTEIN NFAT5 | {
"steps": [
{
"hop": 1,
"source_node_id": "ABL1",
"source_node_type": "GENE",
"source_node_label": "ABL1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "25",
... | PMID:20585028 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ABL1",
"source_db": "UniProt",
"payload": {
"accession": "P00519",
"sequence": "MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSR... | [
{
"source_db": "bridge",
"source_id": "25",
"text": "ABL1 GENE_ENCODES_PROTEIN ABL1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "10725",
"text": "ABL1 PROTEIN_PHYSICALLY_INTERACTS_WITH NFAT5",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"protein_a": "ABL1",
"protein_b": "NFAT5",
"pmid": "20585028",
"experiment": "Biochemical Activity"
} | 0.9 |
co_evid_00160 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between BRCA1 and SUZ12? | BRCA1 GENE_ENCODES_PROTEIN BRCA1 -> BRCA1 PROTEIN_PHYSICALLY_INTERACTS_WITH SUZ12 -> SUZ12 GENE_ENCODES_PROTEIN SUZ12 | {
"steps": [
{
"hop": 1,
"source_node_id": "BRCA1",
"source_node_type": "GENE",
"source_node_label": "BRCA1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "672"... | PMID:23624935 | null | [
"expression",
"intercell_role",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BRCA1",
"source_db": "UniProt",
"payload": {
"accession": "P38398",
"sequence": "MDLSALRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNFAKKENNSPEHLKDEVSIIQSMGYRNR... | [
{
"source_db": "bridge",
"source_id": "672",
"text": "BRCA1 GENE_ENCODES_PROTEIN BRCA1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "23512",
"text": "BRCA1 PROTEIN_PHYSICALLY_INTERACTS_WITH SUZ12",
"confidence": 0.9
},
{
"source_db": "bridge",
"source... | {
"protein_a": "BRCA1",
"protein_b": "SUZ12",
"pmid": "23624935",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00161 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between UBQLN2 and PSMD4? | UBQLN2 GENE_ENCODES_PROTEIN UBQLN2 -> UBQLN2 PROTEIN_PHYSICALLY_INTERACTS_WITH PSMD4 -> PSMD4 GENE_ENCODES_PROTEIN PSMD4 | {
"steps": [
{
"hop": 1,
"source_node_id": "UBQLN2",
"source_node_type": "GENE",
"source_node_label": "UBQLN2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "29... | PMID:30664872 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "UBQLN2",
"source_db": "UniProt",
"payload": {
"accession": "Q9UHD9",
"sequence": "MAENGESSGPPRPSRGPAAAQGSAAAPAEPKIIKVTVKTPKEKEEFAVPENSSVQQFKEAISKRFKSQTDQLVLIFAGKILKDQDTLIQHGIHDGLTVHLVIKSQNRPQGQSTQPSNAAGTNTTSASTPRSN... | [
{
"source_db": "bridge",
"source_id": "29978",
"text": "UBQLN2 GENE_ENCODES_PROTEIN UBQLN2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5710",
"text": "UBQLN2 PROTEIN_PHYSICALLY_INTERACTS_WITH PSMD4",
"confidence": 0.9
},
{
"source_db": "bridge",
"so... | {
"protein_a": "UBQLN2",
"protein_b": "PSMD4",
"pmid": "30664872",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00162 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between WRN and BRCA1? | WRN GENE_ENCODES_PROTEIN WRN -> WRN PROTEIN_PHYSICALLY_INTERACTS_WITH BRCA1 -> BRCA1 GENE_ENCODES_PROTEIN BRCA1 | {
"steps": [
{
"hop": 1,
"source_node_id": "WRN",
"source_node_type": "PROTEIN",
"source_node_label": "WRN",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "7486"... | PMID:24709898 | null | [
"expression",
"intercell_role",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BRCA1",
"source_db": "UniProt",
"payload": {
"accession": "P38398",
"sequence": "MDLSALRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNFAKKENNSPEHLKDEVSIIQSMGYRNR... | [
{
"source_db": "bridge",
"source_id": "7486",
"text": "WRN GENE_ENCODES_PROTEIN WRN",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "672",
"text": "WRN PROTEIN_PHYSICALLY_INTERACTS_WITH BRCA1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "... | {
"protein_a": "WRN",
"protein_b": "BRCA1",
"pmid": "24709898",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00163 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between DTL and MSH6? | DTL GENE_ENCODES_PROTEIN DTL -> DTL PROTEIN_PHYSICALLY_INTERACTS_WITH MSH6 -> MSH6 GENE_ENCODES_PROTEIN MSH6 | {
"steps": [
{
"hop": 1,
"source_node_id": "DTL",
"source_node_type": "GENE",
"source_node_label": "DTL",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "51514",
... | PMID:21725088 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MSH6",
"source_db": "UniProt",
"payload": {
"accession": "P52701",
"sequence": "MSRQSTLYSFFPKSPALSDANKASARASREGGRAAAAPGASPSPGGDAAWSEAGPGPRPLARSASPPKAKNLNGGLRRSVAPAAPTSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSVRVHVQFF... | [
{
"source_db": "bridge",
"source_id": "51514",
"text": "DTL GENE_ENCODES_PROTEIN DTL",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "2956",
"text": "DTL PROTEIN_PHYSICALLY_INTERACTS_WITH MSH6",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": ... | {
"protein_a": "DTL",
"protein_b": "MSH6",
"pmid": "21725088",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00164 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between SOX2 and MSI2? | SOX2 GENE_ENCODES_PROTEIN SOX2 -> SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH MSI2 -> MSI2 GENE_ENCODES_PROTEIN MSI2 | {
"steps": [
{
"hop": 1,
"source_node_id": "SOX2",
"source_node_type": "GENE",
"source_node_label": "SOX2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "6657",... | PMID:23667531 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SOX2",
"source_db": "UniProt",
"payload": {
"accession": "P48431",
"sequence": "MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAP... | [
{
"source_db": "bridge",
"source_id": "6657",
"text": "SOX2 GENE_ENCODES_PROTEIN SOX2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "124540",
"text": "SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH MSI2",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"protein_a": "SOX2",
"protein_b": "MSI2",
"pmid": "23667531",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00165 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between NOTCH1 and KAT5? | NOTCH1 GENE_ENCODES_PROTEIN NOTCH1 -> NOTCH1 PROTEIN_PHYSICALLY_INTERACTS_WITH KAT5 -> KAT5 GENE_ENCODES_PROTEIN KAT5 | {
"steps": [
{
"hop": 1,
"source_node_id": "NOTCH1",
"source_node_type": "GENE",
"source_node_label": "NOTCH1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "48... | PMID:17368826 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "NOTCH1",
"source_db": "UniProt",
"payload": {
"accession": "P46531",
"sequence": "MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPG... | [
{
"source_db": "bridge",
"source_id": "4851",
"text": "NOTCH1 GENE_ENCODES_PROTEIN NOTCH1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "10524",
"text": "NOTCH1 PROTEIN_PHYSICALLY_INTERACTS_WITH KAT5",
"confidence": 0.9
},
{
"source_db": "bridge",
"sou... | {
"protein_a": "NOTCH1",
"protein_b": "KAT5",
"pmid": "17368826",
"experiment": "Phenotypic Suppression"
} | 0.9 |
co_evid_00166 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between MAPK1 and ZNF263? | MAPK1 GENE_ENCODES_PROTEIN MAPK1 -> MAPK1 PROTEIN_PHYSICALLY_INTERACTS_WITH ZNF263 -> ZNF263 GENE_ENCODES_PROTEIN ZNF263 | {
"steps": [
{
"hop": 1,
"source_node_id": "MAPK1",
"source_node_type": "GENE",
"source_node_label": "MAPK1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "5594... | PMID:32051553 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MAPK1",
"source_db": "UniProt",
"payload": {
"accession": "P28482",
"sequence": "MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQI... | [
{
"source_db": "bridge",
"source_id": "5594",
"text": "MAPK1 GENE_ENCODES_PROTEIN MAPK1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "10127",
"text": "MAPK1 PROTEIN_PHYSICALLY_INTERACTS_WITH ZNF263",
"confidence": 0.9
},
{
"source_db": "bridge",
"sour... | {
"protein_a": "MAPK1",
"protein_b": "ZNF263",
"pmid": "32051553",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00167 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between PARK2 and CASS4? | PARK2 GENE_ENCODES_PROTEIN PARK2 -> PARK2 PROTEIN_PHYSICALLY_INTERACTS_WITH CASS4 -> CASS4 GENE_ENCODES_PROTEIN CASS4 | {
"steps": [
{
"hop": 1,
"source_node_id": "PARK2",
"source_node_type": "GENE",
"source_node_label": "PARK2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "5071... | PMID:35509820 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CASS4",
"source_db": "UniProt",
"payload": {
"accession": "Q9NQ75",
"sequence": "MKGTGIMDCAPKALLARALYDNCPDCSDELAFSRGDILTILEQHVPESEGWWKCLLHGRQGLAPANRLQILTEVAADRPCPPFLRGLEEAPASSEETYQVPTLPRPPTPGPVYEQMRSWAEGPQPPTAQVYEF... | [
{
"source_db": "bridge",
"source_id": "5071",
"text": "PARK2 GENE_ENCODES_PROTEIN PARK2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "57091",
"text": "PARK2 PROTEIN_PHYSICALLY_INTERACTS_WITH CASS4",
"confidence": 0.9
},
{
"source_db": "bridge",
"sourc... | {
"protein_a": "PARK2",
"protein_b": "CASS4",
"pmid": "35509820",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00168 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between USP39 and CTNNB1? | USP39 GENE_ENCODES_PROTEIN USP39 -> USP39 PROTEIN_PHYSICALLY_INTERACTS_WITH CTNNB1 -> CTNNB1 GENE_ENCODES_PROTEIN CTNNB1 | {
"steps": [
{
"hop": 1,
"source_node_id": "USP39",
"source_node_type": "GENE",
"source_node_label": "USP39",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1071... | PMID:36707504 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CTNNB1",
"source_db": "UniProt",
"payload": {
"accession": "P35222",
"sequence": "MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQML... | [
{
"source_db": "bridge",
"source_id": "10713",
"text": "USP39 GENE_ENCODES_PROTEIN USP39",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1499",
"text": "USP39 PROTEIN_PHYSICALLY_INTERACTS_WITH CTNNB1",
"confidence": 0.9
},
{
"source_db": "bridge",
"sour... | {
"protein_a": "USP39",
"protein_b": "CTNNB1",
"pmid": "36707504",
"experiment": "Biochemical Activity"
} | 0.9 |
co_evid_00169 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between APP and NAPG? | APP GENE_ENCODES_PROTEIN APP -> APP PROTEIN_PHYSICALLY_INTERACTS_WITH NAPG -> NAPG GENE_ENCODES_PROTEIN NAPG | {
"steps": [
{
"hop": 1,
"source_node_id": "APP",
"source_node_type": "GENE",
"source_node_label": "APP",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "351",
... | PMID:20205790 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "APP",
"source_db": "UniProt",
"payload": {
"accession": "P05067",
"sequence": "MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKF... | [
{
"source_db": "bridge",
"source_id": "351",
"text": "APP GENE_ENCODES_PROTEIN APP",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "8774",
"text": "APP PROTEIN_PHYSICALLY_INTERACTS_WITH NAPG",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "N... | {
"protein_a": "APP",
"protein_b": "NAPG",
"pmid": "20205790",
"experiment": "PCA"
} | 0.9 |
co_evid_00170 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between C9orf72 and KARS? | C9orf72 GENE_ENCODES_PROTEIN C9orf72 -> C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH KARS -> KARS GENE_ENCODES_PROTEIN KARS | {
"steps": [
{
"hop": 1,
"source_node_id": "C9orf72",
"source_node_type": "GENE",
"source_node_label": "C9orf72",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | PMID:37317656 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "C9orf72",
"source_db": "UniProt",
"payload": {
"accession": "Q96LT7",
"sequence": "MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVC... | [
{
"source_db": "bridge",
"source_id": "203228",
"text": "C9orf72 GENE_ENCODES_PROTEIN C9orf72",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "3735",
"text": "C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH KARS",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"protein_a": "C9orf72",
"protein_b": "KARS",
"pmid": "37317656",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00171 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between SPOP and PRDX3? | SPOP GENE_ENCODES_PROTEIN SPOP -> SPOP PROTEIN_PHYSICALLY_INTERACTS_WITH PRDX3 -> PRDX3 GENE_ENCODES_PROTEIN PRDX3 | {
"steps": [
{
"hop": 1,
"source_node_id": "SPOP",
"source_node_type": "GENE",
"source_node_label": "SPOP",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "8405",... | PMID:36604567 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SPOP",
"source_db": "UniProt",
"payload": {
"accession": "O43791",
"sequence": "MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFK... | [
{
"source_db": "bridge",
"source_id": "8405",
"text": "SPOP GENE_ENCODES_PROTEIN SPOP",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "10935",
"text": "SPOP PROTEIN_PHYSICALLY_INTERACTS_WITH PRDX3",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"protein_a": "SPOP",
"protein_b": "PRDX3",
"pmid": "36604567",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00172 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between SOX2 and PARP4? | SOX2 GENE_ENCODES_PROTEIN SOX2 -> SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH PARP4 -> PARP4 GENE_ENCODES_PROTEIN PARP4 | {
"steps": [
{
"hop": 1,
"source_node_id": "SOX2",
"source_node_type": "GENE",
"source_node_label": "SOX2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "6657",... | PMID:34732716 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SOX2",
"source_db": "UniProt",
"payload": {
"accession": "P48431",
"sequence": "MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAP... | [
{
"source_db": "bridge",
"source_id": "6657",
"text": "SOX2 GENE_ENCODES_PROTEIN SOX2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "143",
"text": "SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH PARP4",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"protein_a": "SOX2",
"protein_b": "PARP4",
"pmid": "34732716",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00173 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between KDM4C and TP53? | KDM4C GENE_ENCODES_PROTEIN KDM4C -> KDM4C PROTEIN_PHYSICALLY_INTERACTS_WITH TP53 -> TP53 GENE_ENCODES_PROTEIN TP53 | {
"steps": [
{
"hop": 1,
"source_node_id": "KDM4C",
"source_node_type": "GENE",
"source_node_label": "KDM4C",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "2308... | PMID:33462212 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "TP53",
"source_db": "UniProt",
"payload": {
"accession": "P04637",
"sequence": "MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMF... | [
{
"source_db": "bridge",
"source_id": "23081",
"text": "KDM4C GENE_ENCODES_PROTEIN KDM4C",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7157",
"text": "KDM4C PROTEIN_PHYSICALLY_INTERACTS_WITH TP53",
"confidence": 0.9
},
{
"source_db": "bridge",
"source... | {
"protein_a": "KDM4C",
"protein_b": "TP53",
"pmid": "33462212",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00174 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between AURKB and KLHL21? | AURKB GENE_ENCODES_PROTEIN AURKB -> AURKB PROTEIN_PHYSICALLY_INTERACTS_WITH KLHL21 -> KLHL21 GENE_ENCODES_PROTEIN KLHL21 | {
"steps": [
{
"hop": 1,
"source_node_id": "AURKB",
"source_node_type": "GENE",
"source_node_label": "AURKB",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "9212... | PMID:19995937 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AURKB",
"source_db": "UniProt",
"payload": {
"accession": "Q96GD4",
"sequence": "MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLH... | [
{
"source_db": "bridge",
"source_id": "9212",
"text": "AURKB GENE_ENCODES_PROTEIN AURKB",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "9903",
"text": "AURKB PROTEIN_PHYSICALLY_INTERACTS_WITH KLHL21",
"confidence": 0.9
},
{
"source_db": "bridge",
"sourc... | {
"protein_a": "AURKB",
"protein_b": "KLHL21",
"pmid": "19995937",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00175 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between ATM and CSNK1D? | ATM GENE_ENCODES_PROTEIN ATM -> ATM PROTEIN_PHYSICALLY_INTERACTS_WITH CSNK1D -> CSNK1D GENE_ENCODES_PROTEIN CSNK1D | {
"steps": [
{
"hop": 1,
"source_node_id": "ATM",
"source_node_type": "GENE",
"source_node_label": "ATM",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "472",
... | PMID:22976441 | null | [
"expression",
"protein_sequence"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ATM",
"source_db": "UniProt",
"payload": {
"accession": "Q13315",
"sequence": "MSLVLNDLLICCRQLEHDRATERKKEVEKFKRLIRDPETIKHLDRHSDSKQGKYLNWDAVFRFLQKYIQKETECLRIAKPNVSASTQASRQKKMQEISSLVKYFIKCANRRAPRLKCQELLNYIMDTVKDSSNGA... | [
{
"source_db": "bridge",
"source_id": "472",
"text": "ATM GENE_ENCODES_PROTEIN ATM",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1453",
"text": "ATM PROTEIN_PHYSICALLY_INTERACTS_WITH CSNK1D",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": ... | {
"protein_a": "ATM",
"protein_b": "CSNK1D",
"pmid": "22976441",
"experiment": "Biochemical Activity"
} | 0.9 |
co_evid_00176 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between EP300 and DDX41? | EP300 GENE_ENCODES_PROTEIN EP300 -> EP300 PROTEIN_PHYSICALLY_INTERACTS_WITH DDX41 -> DDX41 GENE_ENCODES_PROTEIN DDX41 | {
"steps": [
{
"hop": 1,
"source_node_id": "EP300",
"source_node_type": "PROTEIN",
"source_node_label": "EP300",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "2... | PMID:33742100 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "DDX41",
"source_db": "UniProt",
"payload": {
"accession": "Q9UJV9",
"sequence": "MEESEPERKRARTDEVPAGGSRSEAEDEDDEDYVPYVPLRQRRQLLLQKLLQRRRKGAAEEEQQDSGSEPRGDEDDIPLGPQSNVSLLDQHQHLKEKAEARKESAKEKQLKEEEKILESVAEGRALMSVKEMA... | [
{
"source_db": "bridge",
"source_id": "2033",
"text": "EP300 GENE_ENCODES_PROTEIN EP300",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "51428",
"text": "EP300 PROTEIN_PHYSICALLY_INTERACTS_WITH DDX41",
"confidence": 0.9
},
{
"source_db": "bridge",
"sourc... | {
"protein_a": "EP300",
"protein_b": "DDX41",
"pmid": "33742100",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00177 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between BRCA1 and CASP1? | BRCA1 GENE_ENCODES_PROTEIN BRCA1 -> BRCA1 PROTEIN_PHYSICALLY_INTERACTS_WITH CASP1 -> CASP1 GENE_ENCODES_PROTEIN CASP1 | {
"steps": [
{
"hop": 1,
"source_node_id": "BRCA1",
"source_node_type": "GENE",
"source_node_label": "BRCA1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "672"... | PMID:26121674 | null | [
"expression",
"intercell_role",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BRCA1",
"source_db": "UniProt",
"payload": {
"accession": "P38398",
"sequence": "MDLSALRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNFAKKENNSPEHLKDEVSIIQSMGYRNR... | [
{
"source_db": "bridge",
"source_id": "672",
"text": "BRCA1 GENE_ENCODES_PROTEIN BRCA1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "834",
"text": "BRCA1 PROTEIN_PHYSICALLY_INTERACTS_WITH CASP1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"protein_a": "BRCA1",
"protein_b": "CASP1",
"pmid": "26121674",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00178 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between CDC42 and CBL? | CDC42 GENE_ENCODES_PROTEIN CDC42 -> CDC42 PROTEIN_PHYSICALLY_INTERACTS_WITH CBL -> CBL GENE_ENCODES_PROTEIN CBL | {
"steps": [
{
"hop": 1,
"source_node_id": "CDC42",
"source_node_type": "PROTEIN",
"source_node_label": "CDC42",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "9... | PMID:14505571 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CBL",
"source_db": "UniProt",
"payload": {
"accession": "P22681",
"sequence": "MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKE... | [
{
"source_db": "bridge",
"source_id": "998",
"text": "CDC42 GENE_ENCODES_PROTEIN CDC42",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "867",
"text": "CDC42 PROTEIN_PHYSICALLY_INTERACTS_WITH CBL",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"protein_a": "CDC42",
"protein_b": "CBL",
"pmid": "14505571",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00179 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between TLR4 and TBK1? | TLR4 GENE_ENCODES_PROTEIN TLR4 -> TLR4 PROTEIN_PHYSICALLY_INTERACTS_WITH TBK1 -> TBK1 GENE_ENCODES_PROTEIN TBK1 | {
"steps": [
{
"hop": 1,
"source_node_id": "TLR4",
"source_node_type": "GENE",
"source_node_label": "TLR4",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "7099",... | PMID:21911421 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "TBK1",
"source_db": "UniProt",
"payload": {
"accession": "Q9UHD2",
"sequence": "MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR... | [
{
"source_db": "bridge",
"source_id": "7099",
"text": "TLR4 GENE_ENCODES_PROTEIN TLR4",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "29110",
"text": "TLR4 PROTEIN_PHYSICALLY_INTERACTS_WITH TBK1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"protein_a": "TLR4",
"protein_b": "TBK1",
"pmid": "21911421",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00180 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between KDM6A and PAXIP1? | KDM6A GENE_ENCODES_PROTEIN KDM6A -> KDM6A PROTEIN_PHYSICALLY_INTERACTS_WITH PAXIP1 -> PAXIP1 GENE_ENCODES_PROTEIN PAXIP1 | {
"steps": [
{
"hop": 1,
"source_node_id": "KDM6A",
"source_node_type": "GENE",
"source_node_label": "KDM6A",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "7403... | PMID:17761849 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "KDM6A",
"source_db": "UniProt",
"payload": {
"accession": "O15550",
"sequence": "MKSCGVSLATAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARTKALLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYPKALSAYQRYYSLQSDYWKNAAFL... | [
{
"source_db": "bridge",
"source_id": "7403",
"text": "KDM6A GENE_ENCODES_PROTEIN KDM6A",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "22976",
"text": "KDM6A PROTEIN_PHYSICALLY_INTERACTS_WITH PAXIP1",
"confidence": 0.9
},
{
"source_db": "bridge",
"sour... | {
"protein_a": "KDM6A",
"protein_b": "PAXIP1",
"pmid": "17761849",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00181 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between EDEM1 and VCP? | EDEM1 GENE_ENCODES_PROTEIN EDEM1 -> EDEM1 PROTEIN_PHYSICALLY_INTERACTS_WITH VCP -> VCP GENE_ENCODES_PROTEIN VCP | {
"steps": [
{
"hop": 1,
"source_node_id": "EDEM1",
"source_node_type": "GENE",
"source_node_label": "EDEM1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "9695... | PMID:32423001 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "VCP",
"source_db": "UniProt",
"payload": {
"accession": "P55072",
"sequence": "MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYL... | [
{
"source_db": "bridge",
"source_id": "9695",
"text": "EDEM1 GENE_ENCODES_PROTEIN EDEM1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7415",
"text": "EDEM1 PROTEIN_PHYSICALLY_INTERACTS_WITH VCP",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"protein_a": "EDEM1",
"protein_b": "VCP",
"pmid": "32423001",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00182 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between SH3YL1 and AR? | SH3YL1 GENE_ENCODES_PROTEIN SH3YL1 -> SH3YL1 PROTEIN_PHYSICALLY_INTERACTS_WITH AR -> AR GENE_ENCODES_PROTEIN AR | {
"steps": [
{
"hop": 1,
"source_node_id": "SH3YL1",
"source_node_type": "GENE",
"source_node_label": "SH3YL1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "26... | PMID:26305679 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AR",
"source_db": "UniProt",
"payload": {
"accession": "P10275",
"sequence": "MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQQQQQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSALECHPERGCVPEPG... | [
{
"source_db": "bridge",
"source_id": "26751",
"text": "SH3YL1 GENE_ENCODES_PROTEIN SH3YL1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "367",
"text": "SH3YL1 PROTEIN_PHYSICALLY_INTERACTS_WITH AR",
"confidence": 0.9
},
{
"source_db": "bridge",
"source... | {
"protein_a": "SH3YL1",
"protein_b": "AR",
"pmid": "26305679",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00183 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between VCP and ZFAND1? | VCP GENE_ENCODES_PROTEIN VCP -> VCP PROTEIN_PHYSICALLY_INTERACTS_WITH ZFAND1 -> ZFAND1 GENE_ENCODES_PROTEIN ZFAND1 | {
"steps": [
{
"hop": 1,
"source_node_id": "VCP",
"source_node_type": "GENE",
"source_node_label": "VCP",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "7415",
... | PMID:34739333 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "VCP",
"source_db": "UniProt",
"payload": {
"accession": "P55072",
"sequence": "MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYL... | [
{
"source_db": "bridge",
"source_id": "7415",
"text": "VCP GENE_ENCODES_PROTEIN VCP",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "79752",
"text": "VCP PROTEIN_PHYSICALLY_INTERACTS_WITH ZFAND1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"protein_a": "VCP",
"protein_b": "ZFAND1",
"pmid": "34739333",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00184 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between EGFR and XRN2? | EGFR GENE_ENCODES_PROTEIN EGFR -> EGFR PROTEIN_PHYSICALLY_INTERACTS_WITH XRN2 -> XRN2 GENE_ENCODES_PROTEIN XRN2 | {
"steps": [
{
"hop": 1,
"source_node_id": "EGFR",
"source_node_type": "GENE",
"source_node_label": "EGFR",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1956",... | PMID:24780295 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "EGFR",
"source_db": "UniProt",
"payload": {
"accession": "P00533",
"sequence": "MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKE... | [
{
"source_db": "bridge",
"source_id": "1956",
"text": "EGFR GENE_ENCODES_PROTEIN EGFR",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "22803",
"text": "EGFR PROTEIN_PHYSICALLY_INTERACTS_WITH XRN2",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"protein_a": "EGFR",
"protein_b": "XRN2",
"pmid": "24780295",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00185 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between DNMT3A and EZH2? | DNMT3A GENE_ENCODES_PROTEIN DNMT3A -> DNMT3A PROTEIN_PHYSICALLY_INTERACTS_WITH EZH2 -> EZH2 GENE_ENCODES_PROTEIN EZH2 | {
"steps": [
{
"hop": 1,
"source_node_id": "DNMT3A",
"source_node_type": "GENE",
"source_node_label": "DNMT3A",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "17... | PMID:16357870 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "DNMT3A",
"source_db": "UniProt",
"payload": {
"accession": "Q9Y6K1",
"sequence": "MPAMPSSGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEGAAETLPEASRAV... | [
{
"source_db": "bridge",
"source_id": "1788",
"text": "DNMT3A GENE_ENCODES_PROTEIN DNMT3A",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "2146",
"text": "DNMT3A PROTEIN_PHYSICALLY_INTERACTS_WITH EZH2",
"confidence": 0.9
},
{
"source_db": "bridge",
"sour... | {
"protein_a": "DNMT3A",
"protein_b": "EZH2",
"pmid": "16357870",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00186 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between HDAC1 and ESR1? | HDAC1 GENE_ENCODES_PROTEIN HDAC1 -> HDAC1 PROTEIN_PHYSICALLY_INTERACTS_WITH ESR1 -> ESR1 GENE_ENCODES_PROTEIN ESR1 | {
"steps": [
{
"hop": 1,
"source_node_id": "HDAC1",
"source_node_type": "PROTEIN",
"source_node_label": "HDAC1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "3... | PMID:14506733 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ESR1",
"source_db": "UniProt",
"payload": {
"accession": "P03372",
"sequence": "MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLEN... | [
{
"source_db": "bridge",
"source_id": "3065",
"text": "HDAC1 GENE_ENCODES_PROTEIN HDAC1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "2099",
"text": "HDAC1 PROTEIN_PHYSICALLY_INTERACTS_WITH ESR1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"protein_a": "HDAC1",
"protein_b": "ESR1",
"pmid": "14506733",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00187 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between PIK3CA and DGKZ? | PIK3CA GENE_ENCODES_PROTEIN PIK3CA -> PIK3CA PROTEIN_PHYSICALLY_INTERACTS_WITH DGKZ -> DGKZ GENE_ENCODES_PROTEIN DGKZ | {
"steps": [
{
"hop": 1,
"source_node_id": "PIK3CA",
"source_node_type": "GENE",
"source_node_label": "PIK3CA",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "52... | PMID:12890670 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PIK3CA",
"source_db": "UniProt",
"payload": {
"accession": "P42336",
"sequence": "MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPVCEFDMVK... | [
{
"source_db": "bridge",
"source_id": "5290",
"text": "PIK3CA GENE_ENCODES_PROTEIN PIK3CA",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "8525",
"text": "PIK3CA PROTEIN_PHYSICALLY_INTERACTS_WITH DGKZ",
"confidence": 0.9
},
{
"source_db": "bridge",
"sour... | {
"protein_a": "PIK3CA",
"protein_b": "DGKZ",
"pmid": "12890670",
"experiment": "Biochemical Activity"
} | 0.9 |
co_evid_00188 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between POLR2A and BCL2? | POLR2A GENE_ENCODES_PROTEIN POLR2A -> POLR2A PROTEIN_PHYSICALLY_INTERACTS_WITH BCL2 -> BCL2 GENE_ENCODES_PROTEIN BCL2 | {
"steps": [
{
"hop": 1,
"source_node_id": "POLR2A",
"source_node_type": "PROTEIN",
"source_node_label": "POLR2A",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": ... | PMID:31594641 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BCL2",
"source_db": "UniProt",
"payload": {
"accession": "P10415",
"sequence": "MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVV... | [
{
"source_db": "bridge",
"source_id": "5430",
"text": "POLR2A GENE_ENCODES_PROTEIN POLR2A",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "596",
"text": "POLR2A PROTEIN_PHYSICALLY_INTERACTS_WITH BCL2",
"confidence": 0.9
},
{
"source_db": "bridge",
"sourc... | {
"protein_a": "POLR2A",
"protein_b": "BCL2",
"pmid": "31594641",
"experiment": "Co-localization"
} | 0.9 |
co_evid_00189 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between SOX2 and RFC5? | SOX2 GENE_ENCODES_PROTEIN SOX2 -> SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH RFC5 -> RFC5 GENE_ENCODES_PROTEIN RFC5 | {
"steps": [
{
"hop": 1,
"source_node_id": "SOX2",
"source_node_type": "GENE",
"source_node_label": "SOX2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "6657",... | PMID:34732716 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SOX2",
"source_db": "UniProt",
"payload": {
"accession": "P48431",
"sequence": "MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAP... | [
{
"source_db": "bridge",
"source_id": "6657",
"text": "SOX2 GENE_ENCODES_PROTEIN SOX2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5985",
"text": "SOX2 PROTEIN_PHYSICALLY_INTERACTS_WITH RFC5",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"protein_a": "SOX2",
"protein_b": "RFC5",
"pmid": "34732716",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00190 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between CREBBP and FOXO3? | CREBBP GENE_ENCODES_PROTEIN CREBBP -> CREBBP PROTEIN_PHYSICALLY_INTERACTS_WITH FOXO3 -> FOXO3 GENE_ENCODES_PROTEIN FOXO3 | {
"steps": [
{
"hop": 1,
"source_node_id": "CREBBP",
"source_node_type": "GENE",
"source_node_label": "CREBBP",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "13... | PMID:12192052 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CREBBP",
"source_db": "UniProt",
"payload": {
"accession": "Q92793",
"sequence": "MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPS... | [
{
"source_db": "bridge",
"source_id": "1387",
"text": "CREBBP GENE_ENCODES_PROTEIN CREBBP",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "2309",
"text": "CREBBP PROTEIN_PHYSICALLY_INTERACTS_WITH FOXO3",
"confidence": 0.9
},
{
"source_db": "bridge",
"sou... | {
"protein_a": "CREBBP",
"protein_b": "FOXO3",
"pmid": "12192052",
"experiment": "Reconstituted Complex"
} | 0.9 |
co_evid_00191 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between CBL and ERBB2? | CBL GENE_ENCODES_PROTEIN CBL -> CBL PROTEIN_PHYSICALLY_INTERACTS_WITH ERBB2 -> ERBB2 GENE_ENCODES_PROTEIN ERBB2 | {
"steps": [
{
"hop": 1,
"source_node_id": "CBL",
"source_node_type": "GENE",
"source_node_label": "CBL",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "867",
... | PMID:12574167 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CBL",
"source_db": "UniProt",
"payload": {
"accession": "P22681",
"sequence": "MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKE... | [
{
"source_db": "bridge",
"source_id": "867",
"text": "CBL GENE_ENCODES_PROTEIN CBL",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "2064",
"text": "CBL PROTEIN_PHYSICALLY_INTERACTS_WITH ERBB2",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "... | {
"protein_a": "CBL",
"protein_b": "ERBB2",
"pmid": "12574167",
"experiment": "Reconstituted Complex"
} | 0.9 |
co_evid_00192 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between NR4A2 and RXRA? | NR4A2 GENE_ENCODES_PROTEIN NR4A2 -> NR4A2 PROTEIN_PHYSICALLY_INTERACTS_WITH RXRA -> RXRA GENE_ENCODES_PROTEIN RXRA | {
"steps": [
{
"hop": 1,
"source_node_id": "NR4A2",
"source_node_type": "GENE",
"source_node_label": "NR4A2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "4929... | PMID:15604093 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "RXRA",
"source_db": "UniProt",
"payload": {
"accession": "P19793",
"sequence": "MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHI... | [
{
"source_db": "bridge",
"source_id": "4929",
"text": "NR4A2 GENE_ENCODES_PROTEIN NR4A2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "6256",
"text": "NR4A2 PROTEIN_PHYSICALLY_INTERACTS_WITH RXRA",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"protein_a": "NR4A2",
"protein_b": "RXRA",
"pmid": "15604093",
"experiment": "Two-hybrid"
} | 0.9 |
co_evid_00193 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between RNGTT and BLM? | RNGTT GENE_ENCODES_PROTEIN RNGTT -> RNGTT PROTEIN_PHYSICALLY_INTERACTS_WITH BLM -> BLM GENE_ENCODES_PROTEIN BLM | {
"steps": [
{
"hop": 1,
"source_node_id": "RNGTT",
"source_node_type": "GENE",
"source_node_label": "RNGTT",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "8732... | PMID:29395067 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BLM",
"source_db": "UniProt",
"payload": {
"accession": "P54132",
"sequence": "MAAVPQNNLQEQLERHSARTLNNKLSLSKPKFSGFTFKKKTSSDNNVSVTNVSVAKTPVLRNKDVNVTEDFSFSEPLPNTTNQQRVKDFFKNAPAGQETQRGGSKSLLPDFLQTPKEVVCTTQNTPTVKKSRDTA... | [
{
"source_db": "bridge",
"source_id": "8732",
"text": "RNGTT GENE_ENCODES_PROTEIN RNGTT",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "641",
"text": "RNGTT PROTEIN_PHYSICALLY_INTERACTS_WITH BLM",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"protein_a": "RNGTT",
"protein_b": "BLM",
"pmid": "29395067",
"experiment": "Proximity Label-MS"
} | 0.9 |
co_evid_00194 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between UTP14A and MYC? | UTP14A GENE_ENCODES_PROTEIN UTP14A -> UTP14A PROTEIN_PHYSICALLY_INTERACTS_WITH MYC -> MYC GENE_ENCODES_PROTEIN MYC | {
"steps": [
{
"hop": 1,
"source_node_id": "UTP14A",
"source_node_type": "GENE",
"source_node_label": "UTP14A",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "10... | PMID:30343112 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MYC",
"source_db": "UniProt",
"payload": {
"accession": "P01106",
"sequence": "MDFFRVVENQQPPATMPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPD... | [
{
"source_db": "bridge",
"source_id": "10813",
"text": "UTP14A GENE_ENCODES_PROTEIN UTP14A",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "4609",
"text": "UTP14A PROTEIN_PHYSICALLY_INTERACTS_WITH MYC",
"confidence": 0.9
},
{
"source_db": "bridge",
"sour... | {
"protein_a": "UTP14A",
"protein_b": "MYC",
"pmid": "30343112",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00195 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between C9orf72 and HMGCR? | C9orf72 GENE_ENCODES_PROTEIN C9orf72 -> C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH HMGCR -> HMGCR GENE_ENCODES_PROTEIN HMGCR | {
"steps": [
{
"hop": 1,
"source_node_id": "C9orf72",
"source_node_type": "GENE",
"source_node_label": "C9orf72",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | PMID:37317656 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "C9orf72",
"source_db": "UniProt",
"payload": {
"accession": "Q96LT7",
"sequence": "MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVC... | [
{
"source_db": "bridge",
"source_id": "203228",
"text": "C9orf72 GENE_ENCODES_PROTEIN C9orf72",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "3156",
"text": "C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH HMGCR",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"protein_a": "C9orf72",
"protein_b": "HMGCR",
"pmid": "37317656",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00196 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between EGFR and ERBB3? | EGFR GENE_ENCODES_PROTEIN EGFR -> EGFR PROTEIN_PHYSICALLY_INTERACTS_WITH ERBB3 -> ERBB3 GENE_ENCODES_PROTEIN ERBB3 | {
"steps": [
{
"hop": 1,
"source_node_id": "EGFR",
"source_node_type": "GENE",
"source_node_label": "EGFR",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1956",... | PMID:10527633 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "EGFR",
"source_db": "UniProt",
"payload": {
"accession": "P00533",
"sequence": "MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKE... | [
{
"source_db": "bridge",
"source_id": "1956",
"text": "EGFR GENE_ENCODES_PROTEIN EGFR",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "2065",
"text": "EGFR PROTEIN_PHYSICALLY_INTERACTS_WITH ERBB3",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"protein_a": "EGFR",
"protein_b": "ERBB3",
"pmid": "10527633",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00197 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between RAC2 and VAPB? | RAC2 GENE_ENCODES_PROTEIN RAC2 -> RAC2 PROTEIN_PHYSICALLY_INTERACTS_WITH VAPB -> VAPB GENE_ENCODES_PROTEIN VAPB | {
"steps": [
{
"hop": 1,
"source_node_id": "RAC2",
"source_node_type": "PROTEIN",
"source_node_label": "RAC2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "588... | PMID:31871319 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "VAPB",
"source_db": "UniProt",
"payload": {
"accession": "O95292",
"sequence": "MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTAPRRYCVRPNSGIIDAGASINVSVMLQPFDYDPNEKSKHKFMVQSMFAPTDTSDMEAVWKEAKPEDLMDSKLRCVFELPAENDKPHD... | [
{
"source_db": "bridge",
"source_id": "5880",
"text": "RAC2 GENE_ENCODES_PROTEIN RAC2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "9217",
"text": "RAC2 PROTEIN_PHYSICALLY_INTERACTS_WITH VAPB",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"protein_a": "RAC2",
"protein_b": "VAPB",
"pmid": "31871319",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00198 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between BCL3 and BARD1? | BCL3 GENE_ENCODES_PROTEIN BCL3 -> BCL3 PROTEIN_PHYSICALLY_INTERACTS_WITH BARD1 -> BARD1 GENE_ENCODES_PROTEIN BARD1 | {
"steps": [
{
"hop": 1,
"source_node_id": "BCL3",
"source_node_type": "GENE",
"source_node_label": "BCL3",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "602",
... | PMID:10362352 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BARD1",
"source_db": "UniProt",
"payload": {
"accession": "Q99728",
"sequence": "MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREPVCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNELSDLKEDKPRKSLF... | [
{
"source_db": "bridge",
"source_id": "602",
"text": "BCL3 GENE_ENCODES_PROTEIN BCL3",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "580",
"text": "BCL3 PROTEIN_PHYSICALLY_INTERACTS_WITH BARD1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id":... | {
"protein_a": "BCL3",
"protein_b": "BARD1",
"pmid": "10362352",
"experiment": "Two-hybrid"
} | 0.9 |
co_evid_00199 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between SQSTM1 and PARP10? | SQSTM1 GENE_ENCODES_PROTEIN SQSTM1 -> SQSTM1 PROTEIN_PHYSICALLY_INTERACTS_WITH PARP10 -> PARP10 GENE_ENCODES_PROTEIN PARP10 | {
"steps": [
{
"hop": 1,
"source_node_id": "SQSTM1",
"source_node_type": "GENE",
"source_node_label": "SQSTM1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "88... | PMID:22992334 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SQSTM1",
"source_db": "UniProt",
"payload": {
"accession": "Q13501",
"sequence": "MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCN... | [
{
"source_db": "bridge",
"source_id": "8878",
"text": "SQSTM1 GENE_ENCODES_PROTEIN SQSTM1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "84875",
"text": "SQSTM1 PROTEIN_PHYSICALLY_INTERACTS_WITH PARP10",
"confidence": 0.9
},
{
"source_db": "bridge",
"s... | {
"protein_a": "SQSTM1",
"protein_b": "PARP10",
"pmid": "22992334",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00200 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between CBL and IPO5? | CBL GENE_ENCODES_PROTEIN CBL -> CBL PROTEIN_PHYSICALLY_INTERACTS_WITH IPO5 -> IPO5 GENE_ENCODES_PROTEIN IPO5 | {
"steps": [
{
"hop": 1,
"source_node_id": "CBL",
"source_node_type": "GENE",
"source_node_label": "CBL",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "867",
... | PMID:36470425 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CBL",
"source_db": "UniProt",
"payload": {
"accession": "P22681",
"sequence": "MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKE... | [
{
"source_db": "bridge",
"source_id": "867",
"text": "CBL GENE_ENCODES_PROTEIN CBL",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "3843",
"text": "CBL PROTEIN_PHYSICALLY_INTERACTS_WITH IPO5",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "I... | {
"protein_a": "CBL",
"protein_b": "IPO5",
"pmid": "36470425",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00201 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between ISG15 and ACTB? | ISG15 GENE_ENCODES_PROTEIN ISG15 -> ISG15 PROTEIN_PHYSICALLY_INTERACTS_WITH ACTB -> ACTB GENE_ENCODES_PROTEIN ACTB | {
"steps": [
{
"hop": 1,
"source_node_id": "ISG15",
"source_node_type": "PROTEIN",
"source_node_label": "ISG15",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "9... | PMID:33024031 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ACTB",
"source_db": "UniProt",
"payload": {
"accession": "P60709",
"sequence": "MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYV... | [
{
"source_db": "bridge",
"source_id": "9636",
"text": "ISG15 GENE_ENCODES_PROTEIN ISG15",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "60",
"text": "ISG15 PROTEIN_PHYSICALLY_INTERACTS_WITH ACTB",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"protein_a": "ISG15",
"protein_b": "ACTB",
"pmid": "33024031",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00202 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between C9orf72 and RPN2? | C9orf72 GENE_ENCODES_PROTEIN C9orf72 -> C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH RPN2 -> RPN2 GENE_ENCODES_PROTEIN RPN2 | {
"steps": [
{
"hop": 1,
"source_node_id": "C9orf72",
"source_node_type": "GENE",
"source_node_label": "C9orf72",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | PMID:37317656 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "C9orf72",
"source_db": "UniProt",
"payload": {
"accession": "Q96LT7",
"sequence": "MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVC... | [
{
"source_db": "bridge",
"source_id": "203228",
"text": "C9orf72 GENE_ENCODES_PROTEIN C9orf72",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "6185",
"text": "C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH RPN2",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"protein_a": "C9orf72",
"protein_b": "RPN2",
"pmid": "37317656",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00203 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between CDC42 and CDKN2A? | CDC42 GENE_ENCODES_PROTEIN CDC42 -> CDC42 PROTEIN_PHYSICALLY_INTERACTS_WITH CDKN2A -> CDKN2A GENE_ENCODES_PROTEIN CDKN2A | {
"steps": [
{
"hop": 1,
"source_node_id": "CDC42",
"source_node_type": "PROTEIN",
"source_node_label": "CDC42",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "9... | PMID:31871319 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CDKN2A",
"source_db": "UniProt",
"payload": {
"accession": "Q8N726",
"sequence": "MVRRFLVTLRIRRACGPPRVRVFVVHIPRLTGEWAAPGAPAAVALVLMLLRSQRLGQQPLPRRPGHDDGQRPSGGAAAAPRRGAQLRRPRHSHPTRARRCPGGLPGHAGGAAPGRGAAGRARCLGPSARGPG... | [
{
"source_db": "bridge",
"source_id": "998",
"text": "CDC42 GENE_ENCODES_PROTEIN CDC42",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1029",
"text": "CDC42 PROTEIN_PHYSICALLY_INTERACTS_WITH CDKN2A",
"confidence": 0.9
},
{
"source_db": "bridge",
"source... | {
"protein_a": "CDC42",
"protein_b": "CDKN2A",
"pmid": "31871319",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00204 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between APOE and APP? | APOE GENE_ENCODES_PROTEIN APOE -> APOE PROTEIN_PHYSICALLY_INTERACTS_WITH APP -> APP GENE_ENCODES_PROTEIN APP | {
"steps": [
{
"hop": 1,
"source_node_id": "APOE",
"source_node_type": "GENE",
"source_node_label": "APOE",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "348",
... | PMID:10842709 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "APOE",
"source_db": "UniProt",
"payload": {
"accession": "P02649",
"sequence": "MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLV... | [
{
"source_db": "bridge",
"source_id": "348",
"text": "APOE GENE_ENCODES_PROTEIN APOE",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "351",
"text": "APOE PROTEIN_PHYSICALLY_INTERACTS_WITH APP",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "... | {
"protein_a": "APOE",
"protein_b": "APP",
"pmid": "10842709",
"experiment": "Protein-peptide"
} | 0.9 |
co_evid_00205 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between SHC1 and CBL? | SHC1 GENE_ENCODES_PROTEIN SHC1 -> SHC1 PROTEIN_PHYSICALLY_INTERACTS_WITH CBL -> CBL GENE_ENCODES_PROTEIN CBL | {
"steps": [
{
"hop": 1,
"source_node_id": "SHC1",
"source_node_type": "PROTEIN",
"source_node_label": "SHC1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "646... | PMID:9541596 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CBL",
"source_db": "UniProt",
"payload": {
"accession": "P22681",
"sequence": "MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKE... | [
{
"source_db": "bridge",
"source_id": "6464",
"text": "SHC1 GENE_ENCODES_PROTEIN SHC1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "867",
"text": "SHC1 PROTEIN_PHYSICALLY_INTERACTS_WITH CBL",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": ... | {
"protein_a": "SHC1",
"protein_b": "CBL",
"pmid": "9541596",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00206 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between MLH1 and AMOT? | MLH1 GENE_ENCODES_PROTEIN MLH1 -> MLH1 PROTEIN_PHYSICALLY_INTERACTS_WITH AMOT -> AMOT GENE_ENCODES_PROTEIN AMOT | {
"steps": [
{
"hop": 1,
"source_node_id": "MLH1",
"source_node_type": "GENE",
"source_node_label": "MLH1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "4292",... | PMID:17148452 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MLH1",
"source_db": "UniProt",
"payload": {
"accession": "P40692",
"sequence": "MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGK... | [
{
"source_db": "bridge",
"source_id": "4292",
"text": "MLH1 GENE_ENCODES_PROTEIN MLH1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "154796",
"text": "MLH1 PROTEIN_PHYSICALLY_INTERACTS_WITH AMOT",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"protein_a": "MLH1",
"protein_b": "AMOT",
"pmid": "17148452",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00207 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between C9orf72 and PFN2? | C9orf72 GENE_ENCODES_PROTEIN C9orf72 -> C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH PFN2 -> PFN2 GENE_ENCODES_PROTEIN PFN2 | {
"steps": [
{
"hop": 1,
"source_node_id": "C9orf72",
"source_node_type": "GENE",
"source_node_label": "C9orf72",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | PMID:37317656 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "C9orf72",
"source_db": "UniProt",
"payload": {
"accession": "Q96LT7",
"sequence": "MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVC... | [
{
"source_db": "bridge",
"source_id": "203228",
"text": "C9orf72 GENE_ENCODES_PROTEIN C9orf72",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5217",
"text": "C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH PFN2",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"protein_a": "C9orf72",
"protein_b": "PFN2",
"pmid": "37317656",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00208 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between GADD45A and AURKA? | GADD45A GENE_ENCODES_PROTEIN GADD45A -> GADD45A PROTEIN_PHYSICALLY_INTERACTS_WITH AURKA -> AURKA GENE_ENCODES_PROTEIN AURKA | {
"steps": [
{
"hop": 1,
"source_node_id": "GADD45A",
"source_node_type": "GENE",
"source_node_label": "GADD45A",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | PMID:20460379 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AURKA",
"source_db": "UniProt",
"payload": {
"accession": "O14965",
"sequence": "MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDF... | [
{
"source_db": "bridge",
"source_id": "1647",
"text": "GADD45A GENE_ENCODES_PROTEIN GADD45A",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "6790",
"text": "GADD45A PROTEIN_PHYSICALLY_INTERACTS_WITH AURKA",
"confidence": 0.9
},
{
"source_db": "bridge",
"... | {
"protein_a": "GADD45A",
"protein_b": "AURKA",
"pmid": "20460379",
"experiment": "Reconstituted Complex"
} | 0.9 |
co_evid_00209 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between CDKN1A and CCNE1? | CDKN1A GENE_ENCODES_PROTEIN CDKN1A -> CDKN1A PROTEIN_PHYSICALLY_INTERACTS_WITH CCNE1 -> CCNE1 GENE_ENCODES_PROTEIN CCNE1 | {
"steps": [
{
"hop": 1,
"source_node_id": "CDKN1A",
"source_node_type": "GENE",
"source_node_label": "CDKN1A",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "10... | PMID:12839982 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CDKN1A",
"source_db": "UniProt",
"payload": {
"accession": "P38936",
"sequence": "MSEPAGDVRQNPCGSKACRRLFGPVDSEQLSRDCDALMAGCIQEARERWNFDFVTETPLEGDFAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTAEEDHVDLSLSCTLVPRSGEQAEGSPG... | [
{
"source_db": "bridge",
"source_id": "1026",
"text": "CDKN1A GENE_ENCODES_PROTEIN CDKN1A",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "898",
"text": "CDKN1A PROTEIN_PHYSICALLY_INTERACTS_WITH CCNE1",
"confidence": 0.9
},
{
"source_db": "bridge",
"sour... | {
"protein_a": "CDKN1A",
"protein_b": "CCNE1",
"pmid": "12839982",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00210 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between HUS1 and MSH6? | HUS1 GENE_ENCODES_PROTEIN HUS1 -> HUS1 PROTEIN_PHYSICALLY_INTERACTS_WITH MSH6 -> MSH6 GENE_ENCODES_PROTEIN MSH6 | {
"steps": [
{
"hop": 1,
"source_node_id": "HUS1",
"source_node_type": "GENE",
"source_node_label": "HUS1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "3364",... | PMID:20188637 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MSH6",
"source_db": "UniProt",
"payload": {
"accession": "P52701",
"sequence": "MSRQSTLYSFFPKSPALSDANKASARASREGGRAAAAPGASPSPGGDAAWSEAGPGPRPLARSASPPKAKNLNGGLRRSVAPAAPTSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSVRVHVQFF... | [
{
"source_db": "bridge",
"source_id": "3364",
"text": "HUS1 GENE_ENCODES_PROTEIN HUS1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "2956",
"text": "HUS1 PROTEIN_PHYSICALLY_INTERACTS_WITH MSH6",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"protein_a": "HUS1",
"protein_b": "MSH6",
"pmid": "20188637",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00211 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between MTOR and USP11? | MTOR GENE_ENCODES_PROTEIN MTOR -> MTOR PROTEIN_PHYSICALLY_INTERACTS_WITH USP11 -> USP11 GENE_ENCODES_PROTEIN USP11 | {
"steps": [
{
"hop": 1,
"source_node_id": "MTOR",
"source_node_type": "GENE",
"source_node_label": "MTOR",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "2475",... | PMID:34600886 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MTOR",
"source_db": "UniProt",
"payload": {
"accession": "P42345",
"sequence": "MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEESTRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDPVVMEMASKAIGRLA... | [
{
"source_db": "bridge",
"source_id": "2475",
"text": "MTOR GENE_ENCODES_PROTEIN MTOR",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "8237",
"text": "MTOR PROTEIN_PHYSICALLY_INTERACTS_WITH USP11",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"protein_a": "MTOR",
"protein_b": "USP11",
"pmid": "34600886",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00212 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between JAK2 and PTPN6? | JAK2 GENE_ENCODES_PROTEIN JAK2 -> JAK2 PROTEIN_PHYSICALLY_INTERACTS_WITH PTPN6 -> PTPN6 GENE_ENCODES_PROTEIN PTPN6 | {
"steps": [
{
"hop": 1,
"source_node_id": "JAK2",
"source_node_type": "GENE",
"source_node_label": "JAK2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "3717",... | PMID:8943354 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "JAK2",
"source_db": "UniProt",
"payload": {
"accession": "O60674",
"sequence": "MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRH... | [
{
"source_db": "bridge",
"source_id": "3717",
"text": "JAK2 GENE_ENCODES_PROTEIN JAK2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5777",
"text": "JAK2 PROTEIN_PHYSICALLY_INTERACTS_WITH PTPN6",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"protein_a": "JAK2",
"protein_b": "PTPN6",
"pmid": "8943354",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00213 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between RARA and AKT1? | RARA GENE_ENCODES_PROTEIN RARA -> RARA PROTEIN_PHYSICALLY_INTERACTS_WITH AKT1 -> AKT1 GENE_ENCODES_PROTEIN AKT1 | {
"steps": [
{
"hop": 1,
"source_node_id": "RARA",
"source_node_type": "PROTEIN",
"source_node_label": "RARA",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "591... | PMID:16417524 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AKT1",
"source_db": "UniProt",
"payload": {
"accession": "P31749",
"sequence": "MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEM... | [
{
"source_db": "bridge",
"source_id": "5914",
"text": "RARA GENE_ENCODES_PROTEIN RARA",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "207",
"text": "RARA PROTEIN_PHYSICALLY_INTERACTS_WITH AKT1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id":... | {
"protein_a": "RARA",
"protein_b": "AKT1",
"pmid": "16417524",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00214 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between SPOP and SNAI1? | SPOP GENE_ENCODES_PROTEIN SPOP -> SPOP PROTEIN_PHYSICALLY_INTERACTS_WITH SNAI1 -> SNAI1 GENE_ENCODES_PROTEIN SNAI1 | {
"steps": [
{
"hop": 1,
"source_node_id": "SPOP",
"source_node_type": "GENE",
"source_node_label": "SPOP",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "8405",... | PMID:32736710 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SPOP",
"source_db": "UniProt",
"payload": {
"accession": "O43791",
"sequence": "MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFK... | [
{
"source_db": "bridge",
"source_id": "8405",
"text": "SPOP GENE_ENCODES_PROTEIN SPOP",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "6615",
"text": "SPOP PROTEIN_PHYSICALLY_INTERACTS_WITH SNAI1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id... | {
"protein_a": "SPOP",
"protein_b": "SNAI1",
"pmid": "32736710",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00215 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between C9orf72 and ILF2? | C9orf72 GENE_ENCODES_PROTEIN C9orf72 -> C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH ILF2 -> ILF2 GENE_ENCODES_PROTEIN ILF2 | {
"steps": [
{
"hop": 1,
"source_node_id": "C9orf72",
"source_node_type": "GENE",
"source_node_label": "C9orf72",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | PMID:37317656 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "C9orf72",
"source_db": "UniProt",
"payload": {
"accession": "Q96LT7",
"sequence": "MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVC... | [
{
"source_db": "bridge",
"source_id": "203228",
"text": "C9orf72 GENE_ENCODES_PROTEIN C9orf72",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "3608",
"text": "C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH ILF2",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"protein_a": "C9orf72",
"protein_b": "ILF2",
"pmid": "37317656",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00216 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between TBK1 and RPTOR? | TBK1 GENE_ENCODES_PROTEIN TBK1 -> TBK1 PROTEIN_PHYSICALLY_INTERACTS_WITH RPTOR -> RPTOR GENE_ENCODES_PROTEIN RPTOR | {
"steps": [
{
"hop": 1,
"source_node_id": "TBK1",
"source_node_type": "GENE",
"source_node_label": "TBK1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "29110"... | PMID:28716898 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "TBK1",
"source_db": "UniProt",
"payload": {
"accession": "Q9UHD2",
"sequence": "MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR... | [
{
"source_db": "bridge",
"source_id": "29110",
"text": "TBK1 GENE_ENCODES_PROTEIN TBK1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "57521",
"text": "TBK1 PROTEIN_PHYSICALLY_INTERACTS_WITH RPTOR",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"protein_a": "TBK1",
"protein_b": "RPTOR",
"pmid": "28716898",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00217 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between DES and BRCA1? | DES GENE_ENCODES_PROTEIN DES -> DES PROTEIN_PHYSICALLY_INTERACTS_WITH BRCA1 -> BRCA1 GENE_ENCODES_PROTEIN BRCA1 | {
"steps": [
{
"hop": 1,
"source_node_id": "DES",
"source_node_type": "PROTEIN",
"source_node_label": "DES",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1674"... | PMID:25184681 | null | [
"expression",
"intercell_role",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BRCA1",
"source_db": "UniProt",
"payload": {
"accession": "P38398",
"sequence": "MDLSALRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNFAKKENNSPEHLKDEVSIIQSMGYRNR... | [
{
"source_db": "bridge",
"source_id": "1674",
"text": "DES GENE_ENCODES_PROTEIN DES",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "672",
"text": "DES PROTEIN_PHYSICALLY_INTERACTS_WITH BRCA1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "... | {
"protein_a": "DES",
"protein_b": "BRCA1",
"pmid": "25184681",
"experiment": "Two-hybrid"
} | 0.9 |
co_evid_00218 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between ESR1 and CUEDC2? | ESR1 GENE_ENCODES_PROTEIN ESR1 -> ESR1 PROTEIN_PHYSICALLY_INTERACTS_WITH CUEDC2 -> CUEDC2 GENE_ENCODES_PROTEIN CUEDC2 | {
"steps": [
{
"hop": 1,
"source_node_id": "ESR1",
"source_node_type": "GENE",
"source_node_label": "ESR1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "2099",... | PMID:21572428 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ESR1",
"source_db": "UniProt",
"payload": {
"accession": "P03372",
"sequence": "MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLEN... | [
{
"source_db": "bridge",
"source_id": "2099",
"text": "ESR1 GENE_ENCODES_PROTEIN ESR1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "79004",
"text": "ESR1 PROTEIN_PHYSICALLY_INTERACTS_WITH CUEDC2",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"protein_a": "ESR1",
"protein_b": "CUEDC2",
"pmid": "21572428",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00219 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between SUCLG2 and CDK1? | SUCLG2 GENE_ENCODES_PROTEIN SUCLG2 -> SUCLG2 PROTEIN_PHYSICALLY_INTERACTS_WITH CDK1 -> CDK1 GENE_ENCODES_PROTEIN CDK1 | {
"steps": [
{
"hop": 1,
"source_node_id": "SUCLG2",
"source_node_type": "GENE",
"source_node_label": "SUCLG2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "88... | PMID:41249152 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CDK1",
"source_db": "UniProt",
"payload": {
"accession": "P06493",
"sequence": "MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNL... | [
{
"source_db": "bridge",
"source_id": "8801",
"text": "SUCLG2 GENE_ENCODES_PROTEIN SUCLG2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "983",
"text": "SUCLG2 PROTEIN_PHYSICALLY_INTERACTS_WITH CDK1",
"confidence": 0.9
},
{
"source_db": "bridge",
"sourc... | {
"protein_a": "SUCLG2",
"protein_b": "CDK1",
"pmid": "41249152",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00220 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between NOTCH1 and HSP90AB1? | NOTCH1 GENE_ENCODES_PROTEIN NOTCH1 -> NOTCH1 PROTEIN_PHYSICALLY_INTERACTS_WITH HSP90AB1 -> HSP90AB1 GENE_ENCODES_PROTEIN HSP90AB1 | {
"steps": [
{
"hop": 1,
"source_node_id": "NOTCH1",
"source_node_type": "GENE",
"source_node_label": "NOTCH1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "48... | PMID:28143869 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "NOTCH1",
"source_db": "UniProt",
"payload": {
"accession": "P46531",
"sequence": "MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPG... | [
{
"source_db": "bridge",
"source_id": "4851",
"text": "NOTCH1 GENE_ENCODES_PROTEIN NOTCH1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "3326",
"text": "NOTCH1 PROTEIN_PHYSICALLY_INTERACTS_WITH HSP90AB1",
"confidence": 0.9
},
{
"source_db": "bridge",
"... | {
"protein_a": "NOTCH1",
"protein_b": "HSP90AB1",
"pmid": "28143869",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00221 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between GATA4 and FUS? | GATA4 GENE_ENCODES_PROTEIN GATA4 -> GATA4 PROTEIN_PHYSICALLY_INTERACTS_WITH FUS -> FUS GENE_ENCODES_PROTEIN FUS | {
"steps": [
{
"hop": 1,
"source_node_id": "GATA4",
"source_node_type": "GENE",
"source_node_label": "GATA4",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "2626... | PMID:35659652 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "FUS",
"source_db": "UniProt",
"payload": {
"accession": "P35637",
"sequence": "MASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPS... | [
{
"source_db": "bridge",
"source_id": "2626",
"text": "GATA4 GENE_ENCODES_PROTEIN GATA4",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "2521",
"text": "GATA4 PROTEIN_PHYSICALLY_INTERACTS_WITH FUS",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"protein_a": "GATA4",
"protein_b": "FUS",
"pmid": "35659652",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00222 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between VCP and RANBP1? | VCP GENE_ENCODES_PROTEIN VCP -> VCP PROTEIN_PHYSICALLY_INTERACTS_WITH RANBP1 -> RANBP1 GENE_ENCODES_PROTEIN RANBP1 | {
"steps": [
{
"hop": 1,
"source_node_id": "VCP",
"source_node_type": "GENE",
"source_node_label": "VCP",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "7415",
... | PMID:35562734 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "VCP",
"source_db": "UniProt",
"payload": {
"accession": "P55072",
"sequence": "MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYL... | [
{
"source_db": "bridge",
"source_id": "7415",
"text": "VCP GENE_ENCODES_PROTEIN VCP",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5902",
"text": "VCP PROTEIN_PHYSICALLY_INTERACTS_WITH RANBP1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id":... | {
"protein_a": "VCP",
"protein_b": "RANBP1",
"pmid": "35562734",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00223 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between PLG and IGFBP3? | PLG GENE_ENCODES_PROTEIN PLG -> PLG PROTEIN_PHYSICALLY_INTERACTS_WITH IGFBP3 -> IGFBP3 GENE_ENCODES_PROTEIN IGFBP3 | {
"steps": [
{
"hop": 1,
"source_node_id": "PLG",
"source_node_type": "GENE",
"source_node_label": "PLG",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "5340",
... | PMID:9688635 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "IGFBP3",
"source_db": "UniProt",
"payload": {
"accession": "P17936",
"sequence": "MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPP... | [
{
"source_db": "bridge",
"source_id": "5340",
"text": "PLG GENE_ENCODES_PROTEIN PLG",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "3486",
"text": "PLG PROTEIN_PHYSICALLY_INTERACTS_WITH IGFBP3",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id":... | {
"protein_a": "PLG",
"protein_b": "IGFBP3",
"pmid": "9688635",
"experiment": "Reconstituted Complex"
} | 0.9 |
co_evid_00224 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between ERBB2 and PPM1A? | ERBB2 GENE_ENCODES_PROTEIN ERBB2 -> ERBB2 PROTEIN_PHYSICALLY_INTERACTS_WITH PPM1A -> PPM1A GENE_ENCODES_PROTEIN PPM1A | {
"steps": [
{
"hop": 1,
"source_node_id": "ERBB2",
"source_node_type": "GENE",
"source_node_label": "ERBB2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "2064... | PMID:28065597 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ERBB2",
"source_db": "UniProt",
"payload": {
"accession": "P04626",
"sequence": "MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGAS... | [
{
"source_db": "bridge",
"source_id": "2064",
"text": "ERBB2 GENE_ENCODES_PROTEIN ERBB2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5494",
"text": "ERBB2 PROTEIN_PHYSICALLY_INTERACTS_WITH PPM1A",
"confidence": 0.9
},
{
"source_db": "bridge",
"source... | {
"protein_a": "ERBB2",
"protein_b": "PPM1A",
"pmid": "28065597",
"experiment": "Two-hybrid"
} | 0.9 |
co_evid_00225 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between NANOG and SPOP? | NANOG GENE_ENCODES_PROTEIN NANOG -> NANOG PROTEIN_PHYSICALLY_INTERACTS_WITH SPOP -> SPOP GENE_ENCODES_PROTEIN SPOP | {
"steps": [
{
"hop": 1,
"source_node_id": "NANOG",
"source_node_type": "PROTEIN",
"source_node_label": "NANOG",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "7... | PMID:30595538 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SPOP",
"source_db": "UniProt",
"payload": {
"accession": "O43791",
"sequence": "MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFK... | [
{
"source_db": "bridge",
"source_id": "79923",
"text": "NANOG GENE_ENCODES_PROTEIN NANOG",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "8405",
"text": "NANOG PROTEIN_PHYSICALLY_INTERACTS_WITH SPOP",
"confidence": 0.9
},
{
"source_db": "bridge",
"source... | {
"protein_a": "NANOG",
"protein_b": "SPOP",
"pmid": "30595538",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00226 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between ABL1 and PIK3R1? | ABL1 GENE_ENCODES_PROTEIN ABL1 -> ABL1 PROTEIN_PHYSICALLY_INTERACTS_WITH PIK3R1 -> PIK3R1 GENE_ENCODES_PROTEIN PIK3R1 | {
"steps": [
{
"hop": 1,
"source_node_id": "ABL1",
"source_node_type": "GENE",
"source_node_label": "ABL1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "25",
... | PMID:8294442 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ABL1",
"source_db": "UniProt",
"payload": {
"accession": "P00519",
"sequence": "MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSR... | [
{
"source_db": "bridge",
"source_id": "25",
"text": "ABL1 GENE_ENCODES_PROTEIN ABL1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5295",
"text": "ABL1 PROTEIN_PHYSICALLY_INTERACTS_WITH PIK3R1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"protein_a": "ABL1",
"protein_b": "PIK3R1",
"pmid": "8294442",
"experiment": "Reconstituted Complex"
} | 0.9 |
co_evid_00227 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between AKT1 and CSNK2A1? | AKT1 GENE_ENCODES_PROTEIN AKT1 -> AKT1 PROTEIN_PHYSICALLY_INTERACTS_WITH CSNK2A1 -> CSNK2A1 GENE_ENCODES_PROTEIN CSNK2A1 | {
"steps": [
{
"hop": 1,
"source_node_id": "AKT1",
"source_node_type": "GENE",
"source_node_label": "AKT1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "207",
... | PMID:37390887 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "AKT1",
"source_db": "UniProt",
"payload": {
"accession": "P31749",
"sequence": "MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEM... | [
{
"source_db": "bridge",
"source_id": "207",
"text": "AKT1 GENE_ENCODES_PROTEIN AKT1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1457",
"text": "AKT1 PROTEIN_PHYSICALLY_INTERACTS_WITH CSNK2A1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"protein_a": "AKT1",
"protein_b": "CSNK2A1",
"pmid": "37390887",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00228 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between CLPP and SNCA? | CLPP GENE_ENCODES_PROTEIN CLPP -> CLPP PROTEIN_PHYSICALLY_INTERACTS_WITH SNCA -> SNCA GENE_ENCODES_PROTEIN SNCA | {
"steps": [
{
"hop": 1,
"source_node_id": "CLPP",
"source_node_type": "GENE",
"source_node_label": "CLPP",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "8192",... | PMID:30877431 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "SNCA",
"source_db": "UniProt",
"payload": {
"accession": "P37840",
"sequence": "MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQ... | [
{
"source_db": "bridge",
"source_id": "8192",
"text": "CLPP GENE_ENCODES_PROTEIN CLPP",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "6622",
"text": "CLPP PROTEIN_PHYSICALLY_INTERACTS_WITH SNCA",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"protein_a": "CLPP",
"protein_b": "SNCA",
"pmid": "30877431",
"experiment": "Reconstituted Complex"
} | 0.9 |
co_evid_00229 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between TRIM33 and CTNNB1? | TRIM33 GENE_ENCODES_PROTEIN TRIM33 -> TRIM33 PROTEIN_PHYSICALLY_INTERACTS_WITH CTNNB1 -> CTNNB1 GENE_ENCODES_PROTEIN CTNNB1 | {
"steps": [
{
"hop": 1,
"source_node_id": "TRIM33",
"source_node_type": "GENE",
"source_node_label": "TRIM33",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "51... | PMID:25639486 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CTNNB1",
"source_db": "UniProt",
"payload": {
"accession": "P35222",
"sequence": "MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQML... | [
{
"source_db": "bridge",
"source_id": "51592",
"text": "TRIM33 GENE_ENCODES_PROTEIN TRIM33",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1499",
"text": "TRIM33 PROTEIN_PHYSICALLY_INTERACTS_WITH CTNNB1",
"confidence": 0.9
},
{
"source_db": "bridge",
"s... | {
"protein_a": "TRIM33",
"protein_b": "CTNNB1",
"pmid": "25639486",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00230 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between CREBBP and STAT3? | CREBBP GENE_ENCODES_PROTEIN CREBBP -> CREBBP PROTEIN_PHYSICALLY_INTERACTS_WITH STAT3 -> STAT3 GENE_ENCODES_PROTEIN STAT3 | {
"steps": [
{
"hop": 1,
"source_node_id": "CREBBP",
"source_node_type": "GENE",
"source_node_label": "CREBBP",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "13... | PMID:11239394 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CREBBP",
"source_db": "UniProt",
"payload": {
"accession": "Q92793",
"sequence": "MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPS... | [
{
"source_db": "bridge",
"source_id": "1387",
"text": "CREBBP GENE_ENCODES_PROTEIN CREBBP",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "6774",
"text": "CREBBP PROTEIN_PHYSICALLY_INTERACTS_WITH STAT3",
"confidence": 0.9
},
{
"source_db": "bridge",
"sou... | {
"protein_a": "CREBBP",
"protein_b": "STAT3",
"pmid": "11239394",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00231 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between BCOR and GPATCH4? | BCOR GENE_ENCODES_PROTEIN BCOR -> BCOR PROTEIN_PHYSICALLY_INTERACTS_WITH GPATCH4 -> GPATCH4 GENE_ENCODES_PROTEIN GPATCH4 | {
"steps": [
{
"hop": 1,
"source_node_id": "BCOR",
"source_node_type": "GENE",
"source_node_label": "BCOR",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "54880"... | PMID:27505670 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BCOR",
"source_db": "UniProt",
"payload": {
"accession": "Q6W2J9",
"sequence": "MLSATPLYGNVHSWMNSERVRMCGASEDRKILVNDGDASKARLELREENPLNHNVVDASTAHRIDGLAALSMDRTGLIREGLRVPGNIVYSSLCGLGSEKGREAATSTLGGLGFSSERNPEMQFKPNTPETVEA... | [
{
"source_db": "bridge",
"source_id": "54880",
"text": "BCOR GENE_ENCODES_PROTEIN BCOR",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "54865",
"text": "BCOR PROTEIN_PHYSICALLY_INTERACTS_WITH GPATCH4",
"confidence": 0.9
},
{
"source_db": "bridge",
"sourc... | {
"protein_a": "BCOR",
"protein_b": "GPATCH4",
"pmid": "27505670",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00232 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between C9orf72 and TRA2A? | C9orf72 GENE_ENCODES_PROTEIN C9orf72 -> C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH TRA2A -> TRA2A GENE_ENCODES_PROTEIN TRA2A | {
"steps": [
{
"hop": 1,
"source_node_id": "C9orf72",
"source_node_type": "GENE",
"source_node_label": "C9orf72",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | PMID:37317656 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "C9orf72",
"source_db": "UniProt",
"payload": {
"accession": "Q96LT7",
"sequence": "MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVC... | [
{
"source_db": "bridge",
"source_id": "203228",
"text": "C9orf72 GENE_ENCODES_PROTEIN C9orf72",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "29896",
"text": "C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH TRA2A",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"protein_a": "C9orf72",
"protein_b": "TRA2A",
"pmid": "37317656",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00233 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between UHRF2 and CDK6? | UHRF2 GENE_ENCODES_PROTEIN UHRF2 -> UHRF2 PROTEIN_PHYSICALLY_INTERACTS_WITH CDK6 -> CDK6 GENE_ENCODES_PROTEIN CDK6 | {
"steps": [
{
"hop": 1,
"source_node_id": "UHRF2",
"source_node_type": "GENE",
"source_node_label": "UHRF2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1154... | PMID:21952639 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CDK6",
"source_db": "UniProt",
"payload": {
"accession": "Q00534",
"sequence": "MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLD... | [
{
"source_db": "bridge",
"source_id": "115426",
"text": "UHRF2 GENE_ENCODES_PROTEIN UHRF2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1021",
"text": "UHRF2 PROTEIN_PHYSICALLY_INTERACTS_WITH CDK6",
"confidence": 0.9
},
{
"source_db": "bridge",
"sourc... | {
"protein_a": "UHRF2",
"protein_b": "CDK6",
"pmid": "21952639",
"experiment": "Far Western"
} | 0.9 |
co_evid_00234 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between JAK2 and EGFR? | JAK2 GENE_ENCODES_PROTEIN JAK2 -> JAK2 PROTEIN_PHYSICALLY_INTERACTS_WITH EGFR -> EGFR GENE_ENCODES_PROTEIN EGFR | {
"steps": [
{
"hop": 1,
"source_node_id": "JAK2",
"source_node_type": "GENE",
"source_node_label": "JAK2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "3717",... | PMID:10358079 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "JAK2",
"source_db": "UniProt",
"payload": {
"accession": "O60674",
"sequence": "MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRH... | [
{
"source_db": "bridge",
"source_id": "3717",
"text": "JAK2 GENE_ENCODES_PROTEIN JAK2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1956",
"text": "JAK2 PROTEIN_PHYSICALLY_INTERACTS_WITH EGFR",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"protein_a": "JAK2",
"protein_b": "EGFR",
"pmid": "10358079",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00235 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between TP53 and OLIG2? | TP53 GENE_ENCODES_PROTEIN TP53 -> TP53 PROTEIN_PHYSICALLY_INTERACTS_WITH OLIG2 -> OLIG2 GENE_ENCODES_PROTEIN OLIG2 | {
"steps": [
{
"hop": 1,
"source_node_id": "TP53",
"source_node_type": "GENE",
"source_node_label": "TP53",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "7157",... | PMID:21397859 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "TP53",
"source_db": "UniProt",
"payload": {
"accession": "P04637",
"sequence": "MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMF... | [
{
"source_db": "bridge",
"source_id": "7157",
"text": "TP53 GENE_ENCODES_PROTEIN TP53",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "10215",
"text": "TP53 PROTEIN_PHYSICALLY_INTERACTS_WITH OLIG2",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"protein_a": "TP53",
"protein_b": "OLIG2",
"pmid": "21397859",
"experiment": "Phenotypic Suppression"
} | 0.9 |
co_evid_00236 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between MYC and HCFC1? | MYC GENE_ENCODES_PROTEIN MYC -> MYC PROTEIN_PHYSICALLY_INTERACTS_WITH HCFC1 -> HCFC1 GENE_ENCODES_PROTEIN HCFC1 | {
"steps": [
{
"hop": 1,
"source_node_id": "MYC",
"source_node_type": "GENE",
"source_node_label": "MYC",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "4609",
... | PMID:31767764 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MYC",
"source_db": "UniProt",
"payload": {
"accession": "P01106",
"sequence": "MDFFRVVENQQPPATMPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPD... | [
{
"source_db": "bridge",
"source_id": "4609",
"text": "MYC GENE_ENCODES_PROTEIN MYC",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "3054",
"text": "MYC PROTEIN_PHYSICALLY_INTERACTS_WITH HCFC1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": ... | {
"protein_a": "MYC",
"protein_b": "HCFC1",
"pmid": "31767764",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00237 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between ATP6V1B2 and ATP6V1A? | ATP6V1B2 GENE_ENCODES_PROTEIN ATP6V1B2 -> ATP6V1B2 PROTEIN_PHYSICALLY_INTERACTS_WITH ATP6V1A -> ATP6V1A GENE_ENCODES_PROTEIN ATP6V1A | {
"steps": [
{
"hop": 1,
"source_node_id": "ATP6V1B2",
"source_node_type": "GENE",
"source_node_label": "ATP6V1B2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id":... | PMID:37831778 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "ATP6V1B2",
"source_db": "UniProt",
"payload": {
"accession": "P21281",
"sequence": "MALRAMRGIVNGAAPELPVPTGGPAVGAREQALAVSRNYLSQPRLTYKTVSGVNGPLVILDHVKFPRYAEIVHLTLPDGTKRSGQVLEVSGSKAVVQVFEGTSGIDAKKTSCEFTGDILRTPVSEDMLGR... | [
{
"source_db": "bridge",
"source_id": "526",
"text": "ATP6V1B2 GENE_ENCODES_PROTEIN ATP6V1B2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "523",
"text": "ATP6V1B2 PROTEIN_PHYSICALLY_INTERACTS_WITH ATP6V1A",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"protein_a": "ATP6V1B2",
"protein_b": "ATP6V1A",
"pmid": "37831778",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00238 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between TRIB3 and MYC? | TRIB3 GENE_ENCODES_PROTEIN TRIB3 -> TRIB3 PROTEIN_PHYSICALLY_INTERACTS_WITH MYC -> MYC GENE_ENCODES_PROTEIN MYC | {
"steps": [
{
"hop": 1,
"source_node_id": "TRIB3",
"source_node_type": "GENE",
"source_node_label": "TRIB3",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "5776... | PMID:33298911 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MYC",
"source_db": "UniProt",
"payload": {
"accession": "P01106",
"sequence": "MDFFRVVENQQPPATMPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPD... | [
{
"source_db": "bridge",
"source_id": "57761",
"text": "TRIB3 GENE_ENCODES_PROTEIN TRIB3",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "4609",
"text": "TRIB3 PROTEIN_PHYSICALLY_INTERACTS_WITH MYC",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"protein_a": "TRIB3",
"protein_b": "MYC",
"pmid": "33298911",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00239 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between VAPB and VAPB? | VAPB GENE_ENCODES_PROTEIN VAPB -> VAPB PROTEIN_PHYSICALLY_INTERACTS_WITH VAPB -> VAPB GENE_ENCODES_PROTEIN VAPB | {
"steps": [
{
"hop": 1,
"source_node_id": "VAPB",
"source_node_type": "GENE",
"source_node_label": "VAPB",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "9217",... | PMID:34948065 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "VAPB",
"source_db": "UniProt",
"payload": {
"accession": "O95292",
"sequence": "MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTAPRRYCVRPNSGIIDAGASINVSVMLQPFDYDPNEKSKHKFMVQSMFAPTDTSDMEAVWKEAKPEDLMDSKLRCVFELPAENDKPHD... | [
{
"source_db": "bridge",
"source_id": "9217",
"text": "VAPB GENE_ENCODES_PROTEIN VAPB",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "9217",
"text": "VAPB PROTEIN_PHYSICALLY_INTERACTS_WITH VAPB",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"protein_a": "VAPB",
"protein_b": "VAPB",
"pmid": "34948065",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00240 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between MID2 and LRRK2? | MID2 GENE_ENCODES_PROTEIN MID2 -> MID2 PROTEIN_PHYSICALLY_INTERACTS_WITH LRRK2 -> LRRK2 GENE_ENCODES_PROTEIN LRRK2 | {
"steps": [
{
"hop": 1,
"source_node_id": "MID2",
"source_node_type": "GENE",
"source_node_label": "MID2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "11043"... | PMID:35266954 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "LRRK2",
"source_db": "UniProt",
"payload": {
"accession": "Q5S007",
"sequence": "MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSERASKLFQGKNIHVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILKMLTVHNASVNLSV... | [
{
"source_db": "bridge",
"source_id": "11043",
"text": "MID2 GENE_ENCODES_PROTEIN MID2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "120892",
"text": "MID2 PROTEIN_PHYSICALLY_INTERACTS_WITH LRRK2",
"confidence": 0.9
},
{
"source_db": "bridge",
"source... | {
"protein_a": "MID2",
"protein_b": "LRRK2",
"pmid": "35266954",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00241 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between RAD51C and XRCC3? | RAD51C GENE_ENCODES_PROTEIN RAD51C -> RAD51C PROTEIN_PHYSICALLY_INTERACTS_WITH XRCC3 -> XRCC3 GENE_ENCODES_PROTEIN XRCC3 | {
"steps": [
{
"hop": 1,
"source_node_id": "RAD51C",
"source_node_type": "GENE",
"source_node_label": "RAD51C",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "58... | PMID:15115758 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "RAD51C",
"source_db": "UniProt",
"payload": {
"accession": "O43502",
"sequence": "MRGKTFRFEMQRDLVSFPLSPAVRVKLVSAGFQTAEELLEVKPSELSKEVGISKAEALETLQIIRRECLTNKPRYAGTSESHKKCTALELLEQEHTQGFIITFCSALDDILGGGVPLMKTTEICGAPGVGKT... | [
{
"source_db": "bridge",
"source_id": "5889",
"text": "RAD51C GENE_ENCODES_PROTEIN RAD51C",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7517",
"text": "RAD51C PROTEIN_PHYSICALLY_INTERACTS_WITH XRCC3",
"confidence": 0.9
},
{
"source_db": "bridge",
"sou... | {
"protein_a": "RAD51C",
"protein_b": "XRCC3",
"pmid": "15115758",
"experiment": "Two-hybrid"
} | 0.9 |
co_evid_00242 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between JUP and CTNNA1? | JUP GENE_ENCODES_PROTEIN JUP -> JUP PROTEIN_PHYSICALLY_INTERACTS_WITH CTNNA1 -> CTNNA1 GENE_ENCODES_PROTEIN CTNNA1 | {
"steps": [
{
"hop": 1,
"source_node_id": "JUP",
"source_node_type": "PROTEIN",
"source_node_label": "JUP",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "3728"... | PMID:9762469 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CTNNA1",
"source_db": "UniProt",
"payload": {
"accession": "P35221",
"sequence": "MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVKRGNMVRAARALL... | [
{
"source_db": "bridge",
"source_id": "3728",
"text": "JUP GENE_ENCODES_PROTEIN JUP",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1495",
"text": "JUP PROTEIN_PHYSICALLY_INTERACTS_WITH CTNNA1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id":... | {
"protein_a": "JUP",
"protein_b": "CTNNA1",
"pmid": "9762469",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00243 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between NUMB and TP53? | NUMB GENE_ENCODES_PROTEIN NUMB -> NUMB PROTEIN_PHYSICALLY_INTERACTS_WITH TP53 -> TP53 GENE_ENCODES_PROTEIN TP53 | {
"steps": [
{
"hop": 1,
"source_node_id": "NUMB",
"source_node_type": "GENE",
"source_node_label": "NUMB",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "8650",... | PMID:18172499 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "TP53",
"source_db": "UniProt",
"payload": {
"accession": "P04637",
"sequence": "MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMF... | [
{
"source_db": "bridge",
"source_id": "8650",
"text": "NUMB GENE_ENCODES_PROTEIN NUMB",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7157",
"text": "NUMB PROTEIN_PHYSICALLY_INTERACTS_WITH TP53",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"protein_a": "NUMB",
"protein_b": "TP53",
"pmid": "18172499",
"experiment": "Affinity Capture-Western"
} | 0.9 |
co_evid_00244 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between PTEN and TTBK2? | PTEN GENE_ENCODES_PROTEIN PTEN -> PTEN PROTEIN_PHYSICALLY_INTERACTS_WITH TTBK2 -> TTBK2 GENE_ENCODES_PROTEIN TTBK2 | {
"steps": [
{
"hop": 1,
"source_node_id": "PTEN",
"source_node_type": "GENE",
"source_node_label": "PTEN",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "5728",... | PMID:15717329 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PTEN",
"source_db": "UniProt",
"payload": {
"accession": "P60484",
"sequence": "MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVM... | [
{
"source_db": "bridge",
"source_id": "5728",
"text": "PTEN GENE_ENCODES_PROTEIN PTEN",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "146057",
"text": "PTEN PROTEIN_PHYSICALLY_INTERACTS_WITH TTBK2",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_... | {
"protein_a": "PTEN",
"protein_b": "TTBK2",
"pmid": "15717329",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_evid_00245 | evidence_attribution | coding_variant | medium | 3 | Which published study provides experimental evidence for the physical interaction between C9orf72 and EIF3B? | C9orf72 GENE_ENCODES_PROTEIN C9orf72 -> C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH EIF3B -> EIF3B GENE_ENCODES_PROTEIN EIF3B | {
"steps": [
{
"hop": 1,
"source_node_id": "C9orf72",
"source_node_type": "GENE",
"source_node_label": "C9orf72",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "... | PMID:37317656 | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "C9orf72",
"source_db": "UniProt",
"payload": {
"accession": "Q96LT7",
"sequence": "MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVC... | [
{
"source_db": "bridge",
"source_id": "203228",
"text": "C9orf72 GENE_ENCODES_PROTEIN C9orf72",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "8662",
"text": "C9orf72 PROTEIN_PHYSICALLY_INTERACTS_WITH EIF3B",
"confidence": 0.9
},
{
"source_db": "bridge",
... | {
"protein_a": "C9orf72",
"protein_b": "EIF3B",
"pmid": "37317656",
"experiment": "Affinity Capture-MS"
} | 0.9 |
co_coun_00000 | counterfactual | coding_variant | hard | 4 | If MLH1 were knocked out, its physical interaction with ATM would be lost. Which disease association of ATM could therefore be indirectly affected? | MLH1 GENE_ENCODES_PROTEIN MLH1 -> MLH1 PROTEIN_PHYSICALLY_INTERACTS_WITH ATM -> ATM GENE_ENCODES_PROTEIN ATM -> ATM GENE_ASSOCIATED_WITH_DISEASE connective tissue disorder | {
"steps": [
{
"hop": 1,
"source_node_id": "MLH1",
"source_node_type": "GENE",
"source_node_label": "MLH1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "4292",... | connective tissue disorder | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "MLH1",
"source_db": "UniProt",
"payload": {
"accession": "P40692",
"sequence": "MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGK... | [
{
"source_db": "bridge",
"source_id": "4292",
"text": "MLH1 GENE_ENCODES_PROTEIN MLH1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "472",
"text": "MLH1 PROTEIN_PHYSICALLY_INTERACTS_WITH ATM",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": ... | {
"knocked_out_gene": "MLH1",
"interaction_partner": "ATM",
"affected_target": "connective tissue disorder",
"target_kind": "disease",
"mechanism": "pairwise"
} | 0.691868 |
co_coun_00001 | counterfactual | coding_variant | hard | 4 | If EGFR were knocked out, its physical interaction with PTEN would be lost. Which disease association of PTEN could therefore be indirectly affected? | EGFR GENE_ENCODES_PROTEIN EGFR -> EGFR PROTEIN_PHYSICALLY_INTERACTS_WITH PTEN -> PTEN GENE_ENCODES_PROTEIN PTEN -> PTEN GENE_ASSOCIATED_WITH_DISEASE Bannayan-Riley-Ruvalcaba syndrome | {
"steps": [
{
"hop": 1,
"source_node_id": "EGFR",
"source_node_type": "GENE",
"source_node_label": "EGFR",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1956",... | Bannayan-Riley-Ruvalcaba syndrome | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "EGFR",
"source_db": "UniProt",
"payload": {
"accession": "P00533",
"sequence": "MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKE... | [
{
"source_db": "bridge",
"source_id": "1956",
"text": "EGFR GENE_ENCODES_PROTEIN EGFR",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "5728",
"text": "EGFR PROTEIN_PHYSICALLY_INTERACTS_WITH PTEN",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"knocked_out_gene": "EGFR",
"interaction_partner": "PTEN",
"affected_target": "Bannayan-Riley-Ruvalcaba syndrome",
"target_kind": "disease",
"mechanism": "pairwise"
} | 0.854418 |
co_coun_00002 | counterfactual | coding_variant | hard | 4 | If CTNNB1 were knocked out, its physical interaction with SOX2 would be lost. Which disease association of SOX2 could therefore be indirectly affected? | CTNNB1 GENE_ENCODES_PROTEIN CTNNB1 -> CTNNB1 PROTEIN_PHYSICALLY_INTERACTS_WITH SOX2 -> SOX2 GENE_ENCODES_PROTEIN SOX2 -> SOX2 GENE_ASSOCIATED_WITH_DISEASE urethra clear cell adenocarcinoma | {
"steps": [
{
"hop": 1,
"source_node_id": "CTNNB1",
"source_node_type": "GENE",
"source_node_label": "CTNNB1",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "14... | urethra clear cell adenocarcinoma | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CTNNB1",
"source_db": "UniProt",
"payload": {
"accession": "P35222",
"sequence": "MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQML... | [
{
"source_db": "bridge",
"source_id": "1499",
"text": "CTNNB1 GENE_ENCODES_PROTEIN CTNNB1",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "6657",
"text": "CTNNB1 PROTEIN_PHYSICALLY_INTERACTS_WITH SOX2",
"confidence": 0.9
},
{
"source_db": "bridge",
"sour... | {
"knocked_out_gene": "CTNNB1",
"interaction_partner": "SOX2",
"affected_target": "urethra clear cell adenocarcinoma",
"target_kind": "disease",
"mechanism": "pairwise"
} | 0.605831 |
co_coun_00003 | counterfactual | coding_variant | hard | 4 | If BCL2 were knocked out, its physical interaction with TP53 would be lost. Which disease association of TP53 could therefore be indirectly affected? | BCL2 GENE_ENCODES_PROTEIN BCL2 -> BCL2 PROTEIN_PHYSICALLY_INTERACTS_WITH TP53 -> TP53 GENE_ENCODES_PROTEIN TP53 -> TP53 GENE_ASSOCIATED_WITH_DISEASE parp inhibitor response | {
"steps": [
{
"hop": 1,
"source_node_id": "BCL2",
"source_node_type": "GENE",
"source_node_label": "BCL2",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "596",
... | parp inhibitor response | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "BCL2",
"source_db": "UniProt",
"payload": {
"accession": "P10415",
"sequence": "MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVV... | [
{
"source_db": "bridge",
"source_id": "596",
"text": "BCL2 GENE_ENCODES_PROTEIN BCL2",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "7157",
"text": "BCL2 PROTEIN_PHYSICALLY_INTERACTS_WITH TP53",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id":... | {
"knocked_out_gene": "BCL2",
"interaction_partner": "TP53",
"affected_target": "parp inhibitor response",
"target_kind": "disease",
"mechanism": "pairwise"
} | 0.766509 |
co_coun_00004 | counterfactual | coding_variant | hard | 4 | If PIK3CA were knocked out, its physical interaction with AKT1 would be lost. Which disease association of AKT1 could therefore be indirectly affected? | PIK3CA GENE_ENCODES_PROTEIN PIK3CA -> PIK3CA PROTEIN_PHYSICALLY_INTERACTS_WITH AKT1 -> AKT1 GENE_ENCODES_PROTEIN AKT1 -> AKT1 GENE_ASSOCIATED_WITH_DISEASE mixed liposarcoma | {
"steps": [
{
"hop": 1,
"source_node_id": "PIK3CA",
"source_node_type": "GENE",
"source_node_label": "PIK3CA",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "52... | mixed liposarcoma | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "PIK3CA",
"source_db": "UniProt",
"payload": {
"accession": "P42336",
"sequence": "MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPVCEFDMVK... | [
{
"source_db": "bridge",
"source_id": "5290",
"text": "PIK3CA GENE_ENCODES_PROTEIN PIK3CA",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "207",
"text": "PIK3CA PROTEIN_PHYSICALLY_INTERACTS_WITH AKT1",
"confidence": 0.9
},
{
"source_db": "bridge",
"sourc... | {
"knocked_out_gene": "PIK3CA",
"interaction_partner": "AKT1",
"affected_target": "mixed liposarcoma",
"target_kind": "disease",
"mechanism": "pairwise"
} | 0.670462 |
co_coun_00005 | counterfactual | coding_variant | hard | 4 | If EGFR were knocked out, its physical interaction with MAPT would be lost. Which disease association of MAPT could therefore be indirectly affected? | EGFR GENE_ENCODES_PROTEIN EGFR -> EGFR PROTEIN_PHYSICALLY_INTERACTS_WITH MAPT -> MAPT GENE_ENCODES_PROTEIN MAPT -> MAPT GENE_ASSOCIATED_WITH_DISEASE diabetic polyneuropathy | {
"steps": [
{
"hop": 1,
"source_node_id": "EGFR",
"source_node_type": "GENE",
"source_node_label": "EGFR",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1956",... | diabetic polyneuropathy | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "EGFR",
"source_db": "UniProt",
"payload": {
"accession": "P00533",
"sequence": "MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKE... | [
{
"source_db": "bridge",
"source_id": "1956",
"text": "EGFR GENE_ENCODES_PROTEIN EGFR",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "4137",
"text": "EGFR PROTEIN_PHYSICALLY_INTERACTS_WITH MAPT",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id"... | {
"knocked_out_gene": "EGFR",
"interaction_partner": "MAPT",
"affected_target": "diabetic polyneuropathy",
"target_kind": "disease",
"mechanism": "pairwise"
} | 0.52756 |
co_coun_00006 | counterfactual | coding_variant | hard | 4 | If CDK6 were knocked out, its physical interaction with CDKN2A would be lost. Which disease association of CDKN2A could therefore be indirectly affected? | CDK6 GENE_ENCODES_PROTEIN CDK6 -> CDK6 PROTEIN_PHYSICALLY_INTERACTS_WITH CDKN2A -> CDKN2A GENE_ENCODES_PROTEIN CDKN2A -> CDKN2A GENE_ASSOCIATED_WITH_DISEASE carcinoma of esophagus | {
"steps": [
{
"hop": 1,
"source_node_id": "CDK6",
"source_node_type": "GENE",
"source_node_label": "CDK6",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1021",... | carcinoma of esophagus | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CDK6",
"source_db": "UniProt",
"payload": {
"accession": "Q00534",
"sequence": "MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLD... | [
{
"source_db": "bridge",
"source_id": "1021",
"text": "CDK6 GENE_ENCODES_PROTEIN CDK6",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "1029",
"text": "CDK6 PROTEIN_PHYSICALLY_INTERACTS_WITH CDKN2A",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_i... | {
"knocked_out_gene": "CDK6",
"interaction_partner": "CDKN2A",
"affected_target": "carcinoma of esophagus",
"target_kind": "disease",
"mechanism": "pairwise"
} | 0.677082 |
co_coun_00007 | counterfactual | coding_variant | hard | 4 | If CBL were knocked out, its physical interaction with FLT3 would be lost. Which disease association of FLT3 could therefore be indirectly affected? | CBL GENE_ENCODES_PROTEIN CBL -> CBL PROTEIN_PHYSICALLY_INTERACTS_WITH FLT3 -> FLT3 GENE_ENCODES_PROTEIN FLT3 -> FLT3 GENE_ASSOCIATED_WITH_DISEASE psoriasis vulgaris | {
"steps": [
{
"hop": 1,
"source_node_id": "CBL",
"source_node_type": "GENE",
"source_node_label": "CBL",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "867",
... | psoriasis vulgaris | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "CBL",
"source_db": "UniProt",
"payload": {
"accession": "P22681",
"sequence": "MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKE... | [
{
"source_db": "bridge",
"source_id": "867",
"text": "CBL GENE_ENCODES_PROTEIN CBL",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "2322",
"text": "CBL PROTEIN_PHYSICALLY_INTERACTS_WITH FLT3",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id": "F... | {
"knocked_out_gene": "CBL",
"interaction_partner": "FLT3",
"affected_target": "psoriasis vulgaris",
"target_kind": "disease",
"mechanism": "pairwise"
} | 0.605831 |
co_coun_00008 | counterfactual | coding_variant | hard | 4 | If EGFR were knocked out, its physical interaction with CDK1 would be lost. Which disease association of CDK1 could therefore be indirectly affected? | EGFR GENE_ENCODES_PROTEIN EGFR -> EGFR PROTEIN_PHYSICALLY_INTERACTS_WITH CDK1 -> CDK1 GENE_ENCODES_PROTEIN CDK1 -> CDK1 GENE_ASSOCIATED_WITH_DISEASE muscular disease | {
"steps": [
{
"hop": 1,
"source_node_id": "EGFR",
"source_node_type": "GENE",
"source_node_label": "EGFR",
"edge_relation": "GENE_ENCODES_PROTEIN",
"edge_evidence_type": "inferred",
"edge_confidence": 0.9,
"edge_source_db": "bridge",
"target_node_id": "1956",... | muscular disease | null | [
"expression",
"protein_sequence",
"protein_structure"
] | [
{
"family": "sequence",
"tag": "protein_sequence",
"anchor_node_id": "EGFR",
"source_db": "UniProt",
"payload": {
"accession": "P00533",
"sequence": "MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKE... | [
{
"source_db": "bridge",
"source_id": "1956",
"text": "EGFR GENE_ENCODES_PROTEIN EGFR",
"confidence": 0.9
},
{
"source_db": "BioGRID",
"source_id": "983",
"text": "EGFR PROTEIN_PHYSICALLY_INTERACTS_WITH CDK1",
"confidence": 0.9
},
{
"source_db": "bridge",
"source_id":... | {
"knocked_out_gene": "EGFR",
"interaction_partner": "CDK1",
"affected_target": "muscular disease",
"target_kind": "disease",
"mechanism": "pairwise"
} | 0.544692 |
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