Datasets:
johnseenun
/
thesis-data

Dataset card Data Studio Files
xet
 Community
text
stringlengths
0
5.79k
==Microscopic==
Features:<ref name=Ref_BP110>{{Ref BP|110}}</ref>
*Abundant (intralobular) stroma - most '''key feature'''.
**Stroma is usually:
***White/pale, i.e. [[myxoid stroma|myxoid]], on H&E (normal stroma is pink).
****May be hyalinized (dark pink) if infarcted.
***Paucicellular - typical.
*Compression of glandular elements - very commonly seen.
**Glandular elements have at least two cell layers - epithelial and myoepithelial.
Notes:
#There is stuff about ''intracanalicular'' vs. ''pericanalicular''.<ref>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970216-9 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970216-9]. Accessed on: 16 March 2011.</ref> It is irrelevant; there is no prognostic differen...
#Do '''not''' comment on the margin - it is irrelevant.
DDx:
*[[Phyllodes tumour]] - long slit-like spaces (seen grossly), stroma is more cellular.
**+/-Mitoses,
**+/-"Stromal overgrowth" = large area where there is a 'loss of glands'.
*Sarcoma.
*[[Pseudoangiomatous stromal hyperplasia]].
**Small capillary-like structures in the stroma.
***Epithelial component often not compressed - as in fibroadenoma.
*[[Adenomyoepithelioma]] - for [[tubular adenoma of the breast]].
===Images===
<gallery>
Image:Breast fibradenoma (1).jpg | Fibroadenoma. (WC/KGH)
Image:Breast_fibradenoma_(2).jpg | Fibroadenoma. (WC/KGH)
</gallery>
www:
*[http://radiographics.rsna.org/content/27/suppl_1/S101/F40.expansion.html Infarcted fibroadenoma (rsna.org)].<ref name=pmid18180221>{{Cite journal | last1 = Sabate | first1 = JM. | last2 = Clotet | first2 = M. | last3 = Torrubia | first3 = S. | last4 = Gomez | first4 = A. | last5 = Guerrero | first5 = R. | last6 = de...
*[http://www.imagingpathways.health.wa.gov.au/includes/images/image/fibroadenoma_he.jpg Fibroadenoma (gov.au)].<ref>URL: [http://www.imagingpathways.health.wa.gov.au/includes/dipmenu/image/image.html http://www.imagingpathways.health.wa.gov.au/includes/dipmenu/image/image.html]. Accessed on: 15 February 2012.</ref>
===Variants===
Four variants are described by the ''Washington Manual'':<ref name=Ref_WMSP262>{{Ref WMSP|262}}</ref>
#Juvenile.
#Complex.
#Myxoid.
#Cellular.
Considered a variant of fibroadenoma by many authorities:<ref name=Ref_BP116>{{Ref BP|116}}</ref>
*''[[Tubular adenoma of the breast]]''.
====Juvenile fibroadenoma====
*As the name suggests, is typically found in younger patients.
*Classic history: rapid growth.
Features (juvenile variant):<ref>URL: [http://www.breastpathology.info/fibro_variants.html#juvenile http://www.breastpathology.info/fibro_variants.html#juvenile]. Accessed on: 3 October 2011.</ref>
*Stromal and epithelial hyperplasia - '''key feature'''.
*+/-Tapering, thin micropapillae (''[[gynecomastoid hyperplasia]]'').<ref name=Ref_BP116>{{Ref BP|116}}</ref>
*Mitoses uncommon.
====Myxoid fibroadenoma====
*May be associated with ''[[Carney's complex]]''.
Features:
*[[Myxoid stroma]].
====Cellular fibroadenoma====
Features (cellular variant):
*Cellular.
*Mitoses.
Note:
*"Cellular" is something that can be subjective. One definition of "cellular" is: "stromal cells are touching one another". Jacobs ''et al.'' has a stromal cellularity picture gallery showing ''mild'' (rare stromal cells touching), ''moderate'' and ''marked'' (many stromal cells touching).<ref name=pmid16191502>{{Cite ...
====Complex fibroadenoma====
*Contain proliferative epithelium which outside and inside a fibroadenoma is associated with an increased risk of malignancy.
Features:<ref>URL: [http://www.breastpathology.info/fibro_variants.html#complex http://www.breastpathology.info/fibro_variants.html#complex]. Accessed on: 3 October 2011.</ref>
# [[Apocrine metaplasia]].
# Cysts > 3 mm.
# Calcification.
# [[Sclerosing adenosis]].
Memory devices:
*''FACS'': complex '''f'''ibroadenoma, '''a'''pocrine metaplasia, '''c'''alcs & '''c'''ysts, '''s'''clerosing adenosis.
*''CAMS'': '''c'''alcs, '''a'''pocrine metaplasia, '''m'''icrocysts, '''s'''clerosing adenosis.
====Tubular adenoma of the breast====
*Considered by many a variant of ''fibroadenoma''.
**[[IHC]] features of ''[[tubular adenoma]] of the breast'' and ''fibroadenoma'' are similar.<ref>{{Cite journal | last1 = Maiorano | first1 = E. | last2 = Albrizio | first2 = M. | title = Tubular adenoma of the breast: an immunohistochemical study of ten cases. | journal = Pathol Res Pract | volume = 191 | issue = 12...
*Most present in adults between menarche and menopause.
Features:<ref name=Ref_BP116>{{Ref BP|116}}</ref>
*Well circumscribed lesion.
*Closely packed uniform tubules, lined by a single layer of epithelial cells and an attenuated myoepithelial cell layer.
*Stroma is generally more sparse than in conventional fibroadenoma
Images:
*[http://www.webpathology.com/image.asp?case=277&n=1 Tubular adenoma of the breast (webpathology.com)].
<gallery>
Image:Breast TubularAdenoma LP CTR.jpg|Breast - Tubular Adenoma - low power (SKB)
Image:Breast TubularAdenoma MP CTR.jpg|Breast - Tubular Adenoma - medium power (SKB)
Image:Breast TubularAdenoma HP CTR.jpg|Breast - Tubular Adenoma - high power (SKB)
Image:Breast TubularAdenoma LP SNP.jpg|Breast - Tubular Adenoma - low power (SKB)
Image:Breast TubularAdenoma MP SNP.jpg|Breast - Tubular Adenoma - medium power (SKB)
Image:Breast TubularAdenoma LactationalChange pa.JPG|Breast - Tubular Adenoma with lactational change (SKB)
Image:Tubular_Adenoma_of_Breast_(myosin_immunostain)_(4351463966).jpg | TA of the breast - myosin IHC. (WC)
</gallery>