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==Sign out==
<pre>
Right Partial Breast, Lumpectomy:
- Fibroadenoma.
</pre>
====Micro====
The sections show a lesion with a pale mildly cellular stroma, and bland glandular elements. No apparent proliferative activity is present. The border is well-circumscribed where seen. Focally, the lesion approaches the inked margin; partial lesion transection cannot be excluded.
No cytologic atypia is present. No leaf-like architecture is present. No stromal overgrowth is seen. No calcifications are evident. No large cysts are seen.
===Complex===
<pre>
Right Breast, Lumpectomy:
- Complex fibroadenoma with apocrine metaplasia.
- Negative for carcinoma in situ and negative for malignancy.
</pre>
====Micro====
The sections show a lesion with a pale mildly cellular stroma, and bland glandular elements. Minimal mitotic activity is present (2 mitosis/10 HPF, where 1 HPF ~ 0.2376 mm*mm). The border is well-circumscribed where seen. The lesion was shelled-out.
No cytologic atypia is present. No leaf-like architecture is present. No stromal overgrowth is seen. No calcifications are evident. No large cysts are seen.
==See also==
*[[Breast pathology]].
*[[Phyllodes tumour]].
==References==
{{Reflist|2}}
[[Category:Diagnosis]]
[[Category:Breast pathology]]
1d6626c0aad01eccfa8e1262d41d7a6fbb00b46c478de88bedafddf1b831c9fd librepath-fibroadenoma.txt
'''Fibrocystic breast changes''', also '''fibrocystic changes''' (abbreviated '''FCC'''), are common changes in the [[breast pathology|breast]] and considered a normal finding.<ref name=pmid25905225>{{Cite journal | last1 = De Groot | first1 = LJ. | last2 = Beck-Peccoz | first2 = P. | last3 = Chrousos | first3 = G. | ...
==General==
*Really common - considered a normal finding.<ref name=pmid25905225/>
*Benign.
==Microscopic==
Features:
*Dilated glands - '''key change'''.
**Glands normal: two cell layers present.
*Often seen together with ''apocrine metaplasia''.
===Images===
<gallery>
Image:Fibrocystic_change_-_intermed_mag.jpg | FCC - intermed. mag. (WC/Nephron)
Image:Fibrocystic_change_-_very_high_mag.jpg | FCC - high mag. (WC/Nephron)
Image:Phyllodes_tumour_-_very_low_mag.jpg | FCC - left of image - and a phyllodes tumour - very low mag. (WC/Nephron)
</gallery>
==See also==
*[[Breast pathology]].
==References==
{{Reflist|1}}
[[Category:Diagnosis]]
[[Category:Breast pathology]]
3ab4fc08e14315db52b5b2d6b7fd16264a8620d6074bcef14cd3fd5ed8a7d6fe librepath-fibrocystic-breast-changes.txt
'''Flat epithelial atypia''', abbreviated '''FEA''', is a benign breast lesion that is associated with an increased risk of subsequent [[breast cancer]].
==General==
Epidemiology:
*Associated with [[ADH]] & [[DCIS]]; may represent a non-obligate precursor lesion of ADH & DCIS.<ref name=pmid18384213>{{Cite journal | last1 = Lerwill | first1 = MF. | title = Flat epithelial atypia of the breast. | journal = Arch Pathol Lab Med | volume = 132 | issue = 4 | pages = 615-21 | month = Apr | year = 2008...
*Low risk of progression to invasive malignancy.<ref name=pmid12927037>{{Cite journal | last1 = Schnitt | first1 = SJ. | title = The diagnosis and management of pre-invasive breast disease: flat epithelial atypia--classification, pathologic features and clinical significance. | journal = Breast Cancer Res | volume = 5...
Management:
*Excision.
==Microscopic==
Features:
*"Flat" ~ three cells thick.
*Hypercellular gland -- several layers.
*Columnar cell morphology.
*+/-Apical snouts.
DDx:
*[[Columnar cell change]].
*Columnar cell hyperplasia.
*[[ADH]].
*Flat [[DCIS]] (clinging carcinoma).
*Apocrine cyst - granular cytoplasm.
*[[Tubular carcinoma]] - should be considered due to the association.
==Images==
<gallery>
Image:Breast FlatAtypia (3) PA.JPG|Breast - Flat Atypia (SKB)
</gallery>
==Molecular==
*Loss of 16q.
**Not used for [[diagnosis]].
==See also==
*[[Breast pathology]].
*[[Atypical ductal hyperplasia]].