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| rhabdoid, papillary
| [[File:Mitoses_anaplastic_meningioma.jpg|thumb|center|150px]]
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==Gross/Radiology==
*Extra-axial, intradural.
**Can be extradural - very rare.<ref name=upmc_case702>URL: [http://path.upmc.edu/cases/case702.html http://path.upmc.edu/cases/case702.html]. Accessed on: 2 February 2012.</ref>
*[[Dural tail sign]] (DTS) on MRI.<ref name=pmid22839655>{{Cite journal | last1 = Ikeda | first1 = D. | last2 = Chiocca | first2 = EA. | title = Editorial: dural tail sign. | journal = J Neurosurg | volume = 117 | issue = 4 | pages = 643-4 | month = Oct | year = 2012 | doi = 10.3171/2012.2.JNS12266 | PMID = 22839655 }...
**Enhancement of dura adjacent to the mass lesion - commonly seen (~70% of cases).<ref name=pmid2120998>{{Cite journal | last1 = Aoki | first1 = S. | last2 = Sasaki | first2 = Y. | last3 = Machida | first3 = T. | last4 = Tanioka | first4 = H. | title = Contrast-enhanced MR images in patients with meningioma: importanc...
**May be subclassified radiologically - predictive of grading.<ref name=pmid22839654>{{Cite journal | last1 = Qi | first1 = ST. | last2 = Liu | first2 = Y. | last3 = Pan | first3 = J. | last4 = Chotai | first4 = S. | last5 = Fang | first5 = LX. | title = A radiopathological classification of dural tail sign of meningi...
*+/-Hyperostosis.
**Associated with invasion into the skull in ~20% of cases.<ref name=pmid22406780>{{Cite journal | last1 = Goyal | first1 = N. | last2 = Kakkar | first2 = A. | last3 = Sarkar | first3 = C. | last4 = Agrawal | first4 = D. | title = Does bony hyperostosis in intracranial meningioma signify tumor invasion? A radio-pathol...
<gallery>
File:Keilbeinmeningeom MRT T1KMax.jpg | Sphenoid wing meningioma (WC/Hellerhoff)
File:Meningioma.jpg | Brain displacement by meningioma (AFIP)
File:Meningioma-1.jpg | Macroscopy (Всеволод Лучанский (vvray))
</gallery>
==Microscopic==
Features (memory device ''WCN''):
*Whorled appearance - '''key feature'''.
*Calcification, [[psammoma bodies|psammomatous]] (target-like appearance; (tight) onion skin).
*+/-[[Nuclear pseudoinclusions]] - focal nuclear clearing with a sharp interface to unremarkable chromatin.
Notes:
*May involute into benign sclerotic tissue.<ref>URL: [http://radiographics.rsna.org/content/23/3/785.long http://radiographics.rsna.org/content/23/3/785.long]. Accessed on: 3 November 2010.</ref>
*Thick-walled blood vessels -> think [[schwannoma]].
DDx:
*[[Schwannoma]] - especially at [[CP angle]].
*[[Solitary fibrous tumour]].
*[[Hemangiopericytoma]].
*Others - see subtypes.
===Images===
<Gallery>
Image:Meningioma_high_mag.jpg | Meningioma - high mag. (WC)
Image:Meningioma_intermed_mag.jpg | Meningioma - intermed. mag. (WC)
Image:Meningioma_-_brain_invasion_-_intermed_mag.jpg | Meningioma with brain invasion - intermed. mag. (WC)
Image:Meningioma_-_brain_invasion_-_high_mag.jpg | Meningioma with brain invasion - high mag. (WC)
File:Meningeotheliomatous_meningeoma_whorl_formations.jpg | Whorls in meningioma. (WC)
File:Image NP T1c 0001.JPG | Whorls in meningioma. (WC)
File:Image NP T1c 0004.JPG | Meningioma annotated. (WC)
</gallery>
www:
*[http://www.neuropathologyweb.org/chapter7/chapter7dMiscellaneous.html Meningioma (neuropathologyweb.org)].
*[http://path.upmc.edu/cases/case702.html Extra-dural meningioma (upmc.edu)].
===Morphologic subtypes===
*Many subtypes exist.<ref name=Ref_PSNP194>{{Ref PSNP|194}}</ref>
*The histologic subtypes generally don't have much prognostic significance.
**Some subtypes are high grade by definition; also see ''histologic grading''.
====Grade I====
=====Meningothelial meningioma=====
*Most common.
Microscopic:
*Syncytial, nuclear clearing ([[pseudoinclusions]]).
*Whorls, Onion bulb formations.
*Few psammoma bodies.
Molecular:
*AKT E17K mutations.<ref>{{Cite journal | last1 = Sahm | first1 = F. | last2 = Bissel | first2 = J. | last3 = Koelsche | first3 = C. | last4 = Schweizer | first4 = L. | last5 = Capper | first5 = D. | last6 = Reuss | first6 = D. | last7 = Böhmer | first7 = K. | last8 = Lass | first8 = U. | last9 = Göck | first9 = T. | ...
<gallery>
Meningeotheliomatous_meningeoma_whorl_formations.jpg | Syncytial appearance, whorl formations (WC/jensflorian)
File:Meningioma_showing_Psammoma_body.jpg | Psammoma body (WC/Netha Hussain)
File:Meningioma_cytologie.jpg | Onion bulb formation in smear (WC/jensflorian)
File:Meningioma_intermed_mag.jpg | Meningioma HPS stain (WC/Nephron)
</gallery>
=====Fibrous meningioma=====
*[[AKA]] ''fibroblastic meningioma''.
*'''Not''' collagen... but looks like it.
**It is really laminin or fibronectin.
*Spindle cells in parallel bundles.
*Few to none whorl formations.
<gallery>
File:Meningioma_fibromatous_variant.jpg | Fibrous meingioma (WC)
File:Miningioma_(4)_EMA.JPG | EMA staining (WC/marvin 101)
</gallery>
=====Transitional meningioma=====
*AKA mixed.
*Common.
*Lobular and fasicular growth patterns coexist.
*Usu. a mixture of meningeothelial and fibromatous meningioma
<gallery>
File:Miningioma_(1)_transitional_type.jpg | Low power (WC/KGH)
File:Miningioma_(2)_transitional_type.jpg | Intermed magnification (WC/KGH)
File:Prominent mitosis meningioma.jpg | Mitosis in a transitional meningioma (WC/jensflorian)
</gallery>
=====Psammomatous meningioma=====
Microscopic:
*[[Psammoma bodies]] dominate over tumor cells.