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BioDecision-4B v2: training data

The exact data BioDecision-4B v2 was trained and tested on: typed biomedical decisions (Choice, Yes/No, Score) in the Tev1 / Jev prompt format. The training pool (train) has 1,750,239 rows; one shuffled epoch processed 1,750,208 of them (the trainer drops the final incomplete batch of 31).

BioDecision family

BioDecision v2 (this release) BioDecision v1 (previous)
Full model: merged weights, load and run biodecision-v2-4b biodecision-tev1-4b
LoRA adapter for Qwen/Qwen3.5-4B biodecision-v2-4b-lora BioDecision v1 LoRA adapter
Training data, test sets and overlap masks biodecision-v2-data BioDecision v1 training data + part 2
Live demo biodecision-demo

What changed from BioDecision v1

  • Training pool: 1,750,239 decisions, 766,914,222 tokens (BioDecision v1: 1,100,763 and 433,417,407).
  • 22 new sources: VAERS, FDA MAUDE, OnSIDES, PHEE (drug and device safety); FDA recalls, FDA warning letters, drug-label sections (regulatory); CDISC COSMoS, MedConceptsQA (standards and coding); ClinicalTrials.gov, TrialPanorama, Chia (trial design); CIViC, ClinVar, Open Targets (genomics); PrimeKG; DDXPlus; BioNLI, BC5CDR; MedInfo; CMExam, CMB (Chinese exams). BioDecision v1's second-stage sources (CT Open training questions, MedHallu, rule-built grounding checks) are counted with v1.
  • BioDecision v1's data re-screened: detected matches to benchmark group IDs, NCT identifiers and normalised complete evidence states were removed during construction; further detected overlaps are excluded through the evaluation masks. DDI and DrugProt were rebuilt with every candidate pair; TrialBench label priors were capped.
  • Robustness variants across existing and newly added sources (prompt injection inside the source, number and unit flips, long documents, not-enough-information cases), with labels derived by deterministic rules.

Tasks

Use case BioDecision v1 decisions BioDecision v2 decisions share sources
Medical exams (English) 321,305 325,451 18.6% headqa, medmcqa, medqa, sciq, ultramedical_medqa_evol, ultramedical_textbookqa
Evidence QA over papers 282,050 290,954 16.6% evidence_inference, medical_abstracts, pubmed_rct, pubmedqa_artificial, pubmedqa_labeled
Trial design and protocol screening 0 132,217 7.6% chia (new), ctgov_usdm (new), trialpanorama (new)
Trial outcome prediction 139,817 114,375 6.5% ct_open_train, trialbench_adverse_event, trialbench_mortality_rate, trialbench_patient_dropout, trialbench_trial_approval, trialbench_trial_duration, trialbench_trial_failure_reason
Patient drug reviews 108,882 112,868 6.4% drug_reviews_condition, drug_reviews_rating
Drug and device safety 7,928 109,136 6.2% ade_corpus, maude (new), onsides (new), phee (new), vaers (new)
Drug, protein and chemical relations 26,278 99,487 5.7% bc5cdr (new), ddi_corpus, drugprot
Genomics and precision oncology 4,068 79,414 4.5% civic (new), clinvar (new), gad, opentargets (new)
Judging answers against a source 71,044 73,417 4.2% grounding_synth, mcq_noul, medhallu_artificial
Patient–trial matching 65,597 64,187 3.7% trec_ct
Data standards and coding (CDISC, ICD, ATC) 0 60,802 3.5% cosmos (new), medconceptsqa (new)
Diagnosis from symptoms 0 54,257 3.1% ddxplus (new)
Regulatory and quality 0 53,279 3.0% fda_enforcement (new), fda_warning_letters (new), spl_sections (new)
Biomedical knowledge graph 0 47,100 2.7% primekg (new)
General decisions (Tev1 replay) 36,867 43,133 2.5% tev1_general
Medical exams (Chinese) 0 37,353 2.1% cmb (new), cmexam (new)
Claim checking and medical NLI 23,247 36,978 2.1% bionli (new), medical_question_pairs, mediqa_rqe, nli4ct, pubhealth, scifact
Medical information questions 13,680 15,831 0.9% medinfo_qtype (new), medquad
Total 1,100,763 1,750,239 100% 57 sources

Splits

Split Decisions Use
train 1,750,239 training (one epoch)
dev 23,847 model selection
calibration 21,407 temperature and confidence-gate fitting, after overlap screening
benchmark 46,199 processed rows from the official test/dev splits of the 28 original benchmarks
benchmark_new 21,798 held-out test rows of the 22 sources added in BioDecision v2

Overlap masks

masks/<split>.json records the rows flagged by the conservative union of two overlap-screening scans, with the reasons: group (shared non-empty group ID), input (same normalised question, evidence and options, in any order), nct (a shared NCT number), or neardup:<train id> (at least half of a sampled sketch of its distinctive 13-word phrases occurs in one training row); scan1 / scan2 record which scan flagged it. Unflagged rows may still share evidence with training. Reported results exclude flagged rows: 1,958 of 46,199 benchmark rows, 2,607 of 21,798 added-source rows, 2,666 calibration rows and 3,206 dev rows. The script is decontam.py.

Where labels come from

label_origin is recorded for 1,729,863 training rows; 20,376 second-stage rows from BioDecision v1 have no value, shown below as unset:

label_origin train rows meaning
gold 1,235,373 the source's own label
derived 182,927 follows deterministically from a source label by a rule: e.g. the yes/no form of an MCQ, and the robustness variants (prompt injection, number and unit flips, long documents)
synthetic_llm 132,929 LLM-written exam questions and answers from UltraMedical (85,190 textbook + 47,739 MedQA-evol)
gold_heuristic 109,065 a source's heuristic or machine-extracted label: PubMedQA's artificial labels (74,447), DDXPlus's simulated differentials (33,114), OnSIDES's model-extracted adverse events (1,504)
rule 49,235 built by a rule with a known answer
unset 20,376 no value recorded (BioDecision v1 second-stage rows: 8,979 CT Open, 7,712 MedHallu with LLM-written candidate answers, 3,685 rule-built grounding checks); labels from the source or a rule
augmented 20,334 earlier augmentations: 17,606 exam 'none of the listed' variants, 1,559 DrugProt other-relation variants, 1,169 Evidence Inference evidence substitutions

No Jev predictions were used as training labels. The pool does include upstream LLM-generated material: UltraMedical's questions and answers (written with GPT-4) and MedHallu's hallucinated answers.

Sources and licences

Research use only: several sources are non-commercial. commercial_ok is recorded where available; 20,376 training rows have no value, which does not establish commercial permission. Respect each source's licence; benchmark test sets belong to their authors.

Source Train decisions Licence New in BioDecision v2
pubmed_rct 195,000 unknown
medmcqa 156,175 Apache-2.0
ultramedical_textbookqa 90,782 MIT
pubmedqa_artificial 76,467 MIT
trec_ct 64,187 CC BY-SA 4.0 (qrels)
mcq_noul 62,020 as parent MCQ
trialpanorama 61,373 Apache-2.0 (TrialPanorama); ClinicalTrials.gov public domain; PubMed abstracts (publisher copyright) yes
drug_reviews_rating 57,875 CC BY 4.0
drug_reviews_condition 54,993 CC BY 4.0
ddxplus 54,257 CC-BY-4.0 (DDXPlus, Mila / Dialogue Health Technologies) yes
drugprot 53,560 CC BY 4.0
ctgov_usdm 53,360 ClinicalTrials.gov (public domain, U.S. NLM) yes
ultramedical_medqa_evol 51,072 MIT
primekg 47,100 CC0-1.0 (PrimeKG); upstream DrugCentral CC BY-SA 4.0; upstream HPO annotations (HPO licence, attribution); upstream DisGeNET CC BY-NC-SA 4.0 yes
tev1_general 43,133 mixed (Together Tev1)
medconceptsqa 38,919 Apache-2.0 (MedConceptsQA); ICD code sets are U.S. government works (public domain); ATC (c) WHOCC Oslo, no commercial copying or distribution yes
vaers 37,901 Public domain (US Gov, CDC/FDA VAERS); via HF mirrors vaers-outcomes (Apache-2.0) and vaers-narrative-generation (CC0-1.0); MedDRA terms yes
maude 35,786 CC0-1.0 (openFDA MAUDE, public domain) yes
ddi_corpus 35,202 CC BY-NC 4.0
trialbench_trial_duration 30,623 unknown (TrialBench)
fda_enforcement 29,308 CC0-1.0 (openFDA, public domain) yes
opentargets 28,383 CC0-1.0 yes
clinvar 23,668 ClinVar (NCBI): attribution requested; submitter-authored text may carry submitter rights; ClinVar (NCBI): US-government public domain facts; attribution requested yes
civic 22,214 CC0-1.0 yes
trialbench_trial_approval 22,051 unknown (TrialBench)
cosmos 21,883 CDISC COSMoS (permission confirmed by CDISC) yes
onsides 19,248 CC-BY-4.0 (OnSIDES v3.1.1; MedDRA term names) yes
cmexam 19,120 Apache-2.0 (github.com/williamliujl/CMExam LICENSE) + README: academic/research use only yes
spl_sections 18,980 CC0-1.0 (openFDA drug labels, public domain) yes
cmb 18,233 Apache-2.0 (github.com/FreedomIntelligence/CMB LICENSE) yes
chia 17,484 CC-BY-4.0 (Chia, Kury et al. 2020) yes
trialbench_trial_failure_reason 15,010 unknown (TrialBench)
medquad 14,931 CC BY 4.0
trialbench_patient_dropout 14,799 unknown (TrialBench)
bionli 12,844 CC BY 4.0 (BioNLI README, github.com/StonyBrookNLP/BioNLI) yes
sciq 12,765 CC BY-NC 3.0
trialbench_mortality_rate 12,179 unknown (TrialBench)
evidence_inference 11,243 MIT
trialbench_adverse_event 10,734 unknown (TrialBench)
bc5cdr 10,725 Public domain (NCBI/NLM US Government Work notice in CDR_Data/README.txt) yes
mediqa_rqe 9,730 unknown
medqa 9,571 CC BY 4.0
ade_corpus 9,073 unknown
ct_open_train 8,979 see CT Open (BioDecision v1 training data, part 2)
medhallu_artificial 7,712 see MedHallu (BioDecision v1 training data, part 2)
medical_abstracts 7,160 CC BY-SA 3.0
phee 7,128 MIT (PHEE, github.com/ZhaoyueSun/PHEE) yes
pubhealth 6,313 MIT
gad 5,149 CC BY 4.0
headqa 5,086 MIT
fda_warning_letters 4,991 Public domain (FDA warning letters, fda.gov) via HF mirror tim-a-wood/fda-warning-letters (card: other); eCFR public domain yes
medical_question_pairs 3,822 unknown
grounding_synth 3,685 derived from licensed rows (BioDecision v1 training data, part 2)
nli4ct 2,469 CC BY-SA 4.0
scifact 1,800 CC BY-NC 2.0
pubmedqa_labeled 1,084 MIT
medinfo_qtype 900 CC-BY-4.0 (MedicationQA, Ben Abacha et al. 2019) yes
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