| --- |
| library_name: pyaging |
| tags: |
| - pyaging |
| - aging-clock |
| - biology |
| - dna-methylation |
| --- |
| |
| # celldrift |
|
|
| Replication signature trained on 31 serially passaged hTERT-immortalized human astrocyte samples. The released 62-PC elastic-net predictor over 2,322 CpGs is folded algebraically into a single linear score. Output is calibrated to cumulative population doublings, not years. Original-author missingness is preserved: supplied NaNs become zero, whereas absent CpGs use module means. GitHub commit 066b3e816795f3c0b372ff8d33f59185a490bd8b; DOI 10.5281/zenodo.7693699. Upstream software license is unspecified (Zenodo: Other (Open)). |
|
|
| Model weights retain the original authors' terms; the pyaging software license does not relicense them. |
|
|
| | | | |
| |---|---| |
| | **Predicts** | mitotic age | |
| | **Species** | Homo sapiens | |
| | **Tissue** | cultured human cells | |
| | **Data type** | DNA methylation | |
| | **Model type** | PCA + elastic net regression | |
| | **Year** | 2023 | |
|
|
| ## Use with pyaging |
|
|
| ```python |
| import pyaging as pya |
| |
| pya.pred.predict_age(adata, ["celldrift"]) |
| ``` |
|
|
| Browse every clock in the [pyaging Clock Catalogue](https://pyaging.readthedocs.io). |
|
|
| ## Citation |
|
|
| Minteer, C. J., et al. (2023). More than bad luck: Cancer and aging are linked to replication-driven changes to the epigenome. Science Advances, 9(29), eadf4163. |
|
|
| https://doi.org/10.1126/sciadv.adf4163 |
|
|
