| { |
| "approved_by_author": "\u231b", |
| "citation": "Minteer, C. J., et al. (2023). More than bad luck: Cancer and aging are linked to replication-driven changes to the epigenome. Science Advances, 9(29), eadf4163.", |
| "citations": 29, |
| "citations_date": "2026-10-02", |
| "clock_name": "celldrift", |
| "data_type": "DNA methylation", |
| "doi": "https://doi.org/10.1126/sciadv.adf4163", |
| "journal": "Science Advances", |
| "last_author": "Morgan E. Levine", |
| "model_type": "PCA + elastic net regression", |
| "n_features": 2322, |
| "notes": "Replication signature trained on 31 serially passaged hTERT-immortalized human astrocyte samples. The released 62-PC elastic-net predictor over 2,322 CpGs is folded algebraically into a single linear score. Output is calibrated to cumulative population doublings, not years. Original-author missingness is preserved: supplied NaNs become zero, whereas absent CpGs use module means. GitHub commit 066b3e816795f3c0b372ff8d33f59185a490bd8b; DOI 10.5281/zenodo.7693699. Upstream software license is unspecified (Zenodo: Other (Open)).", |
| "platform": [ |
| "Illumina EPIC" |
| ], |
| "population": "human cell cultures", |
| "predicts": [ |
| "mitotic age" |
| ], |
| "preprocess": "supplied NaNs to zero; absent CpGs to module means", |
| "reference_values": true, |
| "research_only": null, |
| "species": "Homo sapiens", |
| "tissue": [ |
| "cultured human cells" |
| ], |
| "training_target": [ |
| "population doublings" |
| ], |
| "unit": [ |
| "population doublings" |
| ], |
| "version": "0.5.4", |
| "year": 2023 |
| } |
