metadata
library_name: pyaging
tags:
- pyaging
- aging-clock
- biology
- dna-methylation
mccartneybmi
Whole-blood DNAm LASSO score for body mass index (BMI), trained in Generation Scotland on an age-, sex-, and ancestry-adjusted phenotype residual and evaluated out of sample in LBC1936. BMI was log-transformed before residualization. The current pyaging implementation applies a sigmoid to the linear score, so the returned value is bounded and unitless. It is neither the original continuous phenotype residual nor a calibrated probability; the paper does not specify this sigmoid.
Model weights retain the original authors' terms; the pyaging software license does not relicense them.
| Predicts | body mass index |
| Species | Homo sapiens |
| Tissue | whole blood |
| Data type | DNA methylation |
| Model type | LASSO regression |
| Year | 2018 |
Use with pyaging
import pyaging as pya
pya.pred.predict_age(adata, ["mccartneybmi"])
Browse every clock in the pyaging Clock Catalogue.
Citation
McCartney, D. L., et al. “Epigenetic prediction of complex traits and death.” Genome Biology 19, 136 (2018).