metadata
library_name: pyaging
tags:
- pyaging
- aging-clock
- biology
- dna-methylation
neusin
Neu-Sin is a neuron semi-intrinsic chronological-age clock: elastic-net regression was restricted to neuron age-DMCTs but fitted to methylation values not adjusted for brain cell fractions. Coefficients were fitted in the 450K Jaffe cortex cohort; the regularization penalty was selected on the EPIC Pihlstrom cohort.
Model weights retain the original authors' terms; the pyaging software license does not relicense them.
| Predicts | chronological age |
| Species | Homo sapiens |
| Tissue | brain cortex |
| Data type | DNA methylation |
| Model type | elastic net regression |
| Year | 2024 |
Use with pyaging
import pyaging as pya
pya.pred.predict_age(adata, ["neusin"])
Browse every clock in the pyaging Clock Catalogue.
Citation
Tong, Huige, et al. "Cell-type specific epigenetic clocks to quantify biological age at cell-type resolution." Aging 16 (2024): 13452–13504.