metadata
library_name: pyaging
tags:
- pyaging
- aging-clock
- biology
- dna-methylation
replitalinorm
Upstream starting-PD normalization model used during RepliTali construction. It was trained only in the chronologically youngest fetal skin fibroblast line (AG06561) to estimate the unobserved pre-culture replicative-history offset; it is not the final 87-CpG RepliTali model.
Model weights retain the original authors' terms; the pyaging software license does not relicense them.
| Predicts | replicative history |
| Species | Homo sapiens |
| Tissue | cultured fibroblasts |
| Data type | DNA methylation |
| Model type | elastic net regression |
| Year | 2022 |
Use with pyaging
import pyaging as pya
pya.pred.predict_age(adata, ["replitalinorm"])
Browse every clock in the pyaging Clock Catalogue.
Citation
Endicott, J.L., Nolte, P.A., Shen, H. & Laird, P.W. Cell division drives DNA methylation loss in late-replicating domains in primary human cells. Nature Communications 13, 6659 (2022).