senchronoage / README.md
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metadata
library_name: pyaging
tags:
  - pyaging
  - aging-clock
  - biology
  - dna-methylation

senchronoage

Senescence-enriched chronological-age predictor restricted to CpGs whose directions were concordant across in-vitro senescence, age and mortality analyses.

Model weights retain the original authors' terms; the pyaging software license does not relicense them.

Predicts chronological age
Species Homo sapiens
Tissue whole blood
Data type DNA methylation
Model type elastic net regression
Year 2026

Use with pyaging

import pyaging as pya

pya.pred.predict_age(adata, ["senchronoage"])

Browse every clock in the pyaging Clock Catalogue.

Citation

Kasamoto, K., Gibson, J., Moqri, M., Smith, R. & Higgins-Chen, A.T. DNA methylation signatures of cellular senescence are not reversed by senolytic treatment. Aging Cell 25, e70430 (2026).

https://doi.org/10.1111/acel.70430