metadata
library_name: pyaging
tags:
- pyaging
- aging-clock
- biology
- dna-methylation
xchrom
X-chromosome first-principal-component score used with the Y score to infer X dosage and classify 46,XX, 46,XY, 45,X, and 47,XXY samples. Feature screening and PCA used 450K whole-blood data from 18-year-olds; EPIC data were used for validation.
Model weights retain the original authors' terms; the pyaging software license does not relicense them.
| Predicts | X-chromosome dosage |
| Species | Homo sapiens |
| Tissue | whole blood |
| Data type | DNA methylation |
| Model type | principal component analysis |
| Year | 2021 |
Use with pyaging
import pyaging as pya
pya.pred.predict_age(adata, ["xchrom"])
Browse every clock in the pyaging Clock Catalogue.
Citation
Wang, Y. et al. DNA methylation-based sex classifier to predict sex and identify sex chromosome aneuploidy. BMC Genomics 22, 484 (2021).