example_data_description.md

SecA HDX-MS protein flexibility data

This is an example dataset of HDX-MS derived protein flexibility, expressed as Linderström-Lang Gibbs free energies (ΔG/ΔΔG).

The ΔG values obtained using PyHDX (DOI: 10.1021/acs.analchem.1c02155)

There are three protein states, SecA monomer, SecA dimer and SecA with C-tail deletion, each state as apo (ΔG) and ADP-bound (ΔΔG)

More details on SecA dynamics can be found here: A nexus of intrinsic dynamics underlies translocase priming