pretty_name: PhaseFlow
license: apache-2.0
library_name: pytorch
tags:
- protein
- peptide
- liquid-liquid-phase-separation
- disordered-protein-regions
- pytorch
PhaseFlow
This repository hosts the unified PhaseFlow runtime checkpoint used for peptide phase prediction, full-length protein LLPS prediction, and droplet-promoting region (DPR) localization.
| Component | Task | Embedded weights |
|---|---|---|
| Peptide PhaseFlow | Short-peptide 4×4 PSSI phase-diagram prediction and phase-conditioned sequence generation | Peptide tokenizer, shared Transformer, and Flow Matching stack |
| CondenGT / LLPS | Protein-level liquid-liquid phase-separation prediction | Full-protein sequence-context encoder and LLPS readout |
| DPR stack | Driving phase-separation region localization | Region-scoring head and post-processing state for DPR scanning |
Download the checkpoint with:
hf download GENTEL-Lab/PhaseFlow PhaseFlow.pt --local-dir artifacts/models
Related resources
| Resource | Link | Role |
|---|---|---|
| PhaseFlow code | github.com/GENTEL-lab/PhaseFlow | Installation, inference scripts, configs, and documentation |
| OpenPhase training data | GENTEL-Lab/OpenPhase | Public peptide, LLPS, and DPR research-data packages |
| Online demo | phaseflow.bio | Interactive PhaseFlow usage |
Open access
The checkpoint and accompanying model card in this repository are fully open source and freely available to the community. We warmly welcome their use in research, benchmarking, method development, and reproducible studies. Please cite the relevant PhaseFlow work and retain appropriate source attribution when using or redistributing the weights.
Integrity
This repository contains metadata/file_inventory.csv. Verify all listed files
before use; the inventory intentionally excludes itself to avoid a
self-referential checksum.
import csv
import hashlib
from pathlib import Path
repo = Path(".")
with (repo / "metadata/file_inventory.csv").open(newline="") as handle:
for item in csv.DictReader(handle):
digest = hashlib.sha256((repo / item["path"]).read_bytes()).hexdigest()
assert digest == item["sha256"], item["path"]
| File | Description | SHA256 |
|---|---|---|
PhaseFlow.pt |
Combined PhaseFlow runtime checkpoint (peptide, full-protein, and DPR weights) | 7fb0091e6dd5a85bd3a6be7a0b606501700c4b8f28ff9b6e309267835a2fdff0 |
Responsible use
These weights are research resources, not clinical or diagnostic tools. Model predictions require independent validation and must be interpreted under the documented evidence and coordinate conventions in the PhaseFlow codebase.