| { |
| "frozen_cache": { |
| "identity_axis_sha256": "c6765f386d066ec731442316c88395acee2ab6fbef009a5a2fd59696b738b6fd", |
| "path": "inputs/responses_ab.npy", |
| "sha256": "bb48bae7f864c66b242a77cef064ff967b418d22bb11416630548f6a6d094a94", |
| "shape": [ |
| 2, |
| 9205, |
| 8248 |
| ] |
| }, |
| "gate_decision": "PASS: `view_specific_batch_weighted` reproduces every sampled FIT/SELECT delta element at atol=1e-05, rtol=1e-05. Gate 2 may materialize quarantined endpoint assets using this exact recipe, then must validate the invariant on all identities before release.", |
| "pairing_statement": "Each endpoint candidate has a deterministic perturbation pseudobulk goal in each A/B batch-disjoint view. The source candidate is a deterministic weighted mixture of batch-specific control pseudobulks; this audit tests whether its weights are pooled across views or restricted to the endpoint view.", |
| "raw": { |
| "aggregation": "per-cell library-size 10000 then log1p; mean pseudobulk", |
| "gene_order_exact_match": true, |
| "path": "PUBLIC_SOURCE/ReplogleWeissman2022_K562_gwps.h5ad", |
| "sha256": "d3269d9c863d96555eba768b42ab330cc1b57493cd33b4ac8fe7fbab8278f104", |
| "shape": [ |
| 1989578, |
| 8248 |
| ] |
| }, |
| "sample": { |
| "count": 64, |
| "identities": [ |
| "OSBPL8", |
| "SSX4", |
| "ZNF576", |
| "NFE2L1", |
| "NRIP1", |
| "SEC16A", |
| "CSNK1A1", |
| "CRADD", |
| "SYVN1", |
| "SPATA2L", |
| "DNAJC30", |
| "UPRT", |
| "TLE3", |
| "ARGFX", |
| "IFT80", |
| "ZSCAN23", |
| "MLF2", |
| "LARP4", |
| "HIST1H2BL", |
| "GEMIN7", |
| "TKT", |
| "ERVW-1", |
| "C14orf178", |
| "ZNF384", |
| "NOTUM", |
| "GAA", |
| "BTBD10", |
| "COX16", |
| "MAP1LC3B", |
| "ATF6", |
| "PPP2R3B", |
| "EBAG9", |
| "SRP72", |
| "EIF2B5", |
| "L3HYPDH", |
| "OTP", |
| "OTX2", |
| "ENTR1", |
| "DCPS", |
| "TICRR", |
| "TAX1BP3", |
| "COCH", |
| "ZFPL1", |
| "GNA13", |
| "ZNF442", |
| "VENTX", |
| "ZBTB40", |
| "STX6", |
| "SMG6", |
| "MTMR4", |
| "RELA", |
| "BBC3", |
| "MOK", |
| "CTPS2", |
| "PSMC1", |
| "ZNF48", |
| "ATP1A1", |
| "RAP2B", |
| "DARS", |
| "PIN4", |
| "MIF", |
| "ARL6IP1", |
| "TASOR2", |
| "CWC15" |
| ], |
| "roles": [ |
| "G_fit", |
| "G_select" |
| ], |
| "selection": "SHA-256 deterministic identity order with salt SOURCE_GOAL_ASSET_RESOLUTION_V1|20260916" |
| }, |
| "sampled_cache_recipe_comparison": { |
| "all_batch_weighted": { |
| "A": { |
| "all_close": false, |
| "fraction_close": 0.002911690712900097, |
| "max_abs_error": 0.07813365560047059, |
| "mean_abs_error": 0.0030257416010429335 |
| }, |
| "B": { |
| "all_close": false, |
| "fraction_close": 0.002907901915615907, |
| "max_abs_error": 0.09024386034321341, |
| "mean_abs_error": 0.003004935907370192 |
| } |
| }, |
| "view_specific_batch_weighted": { |
| "A": { |
| "all_close": true, |
| "fraction_close": 1.0, |
| "max_abs_error": 1.4648724722121642e-06, |
| "mean_abs_error": 9.106084045687916e-09 |
| }, |
| "B": { |
| "all_close": true, |
| "fraction_close": 1.0, |
| "max_abs_error": 1.4948276128023963e-06, |
| "mean_abs_error": 8.249161447296022e-09 |
| } |
| } |
| }, |
| "schema": "SOURCE_GOAL_ASSET_RESOLUTION_V1_GATE_1", |
| "source_diversity": { |
| "all_batch_weighted_shared_across_views": { |
| "control_mean_matrix_rank": 267, |
| "coordinate_variance_mean": 1.4186932821180593e-05, |
| "distinct_control_mixture_profile_fraction": 1.0, |
| "distinct_control_mixture_profiles": 9205, |
| "distinct_source_expression_profile_fraction": 1.0, |
| "distinct_source_expression_profiles_float32": 9205, |
| "max_perturbations_per_control_mixture": 1, |
| "queries": 9205, |
| "sample_pair_count": 10000, |
| "sample_pair_max_l2_distance": 1.3801618177203594, |
| "sample_pair_mean_l2_distance": 0.4570262069036828, |
| "sample_pair_median_l2_distance": 0.42392650150797745, |
| "source_profile_identity_proven": true |
| }, |
| "view_A_batch_weighted": { |
| "control_mean_matrix_rank": 267, |
| "coordinate_variance_mean": 2.707875577707947e-05, |
| "distinct_control_mixture_profile_fraction": 1.0, |
| "distinct_control_mixture_profiles": 9205, |
| "distinct_source_expression_profile_fraction": 1.0, |
| "distinct_source_expression_profiles_float32": 9205, |
| "max_perturbations_per_control_mixture": 1, |
| "queries": 9205, |
| "sample_pair_count": 10000, |
| "sample_pair_max_l2_distance": 2.3858092804354647, |
| "sample_pair_mean_l2_distance": 0.6300420630208424, |
| "sample_pair_median_l2_distance": 0.5824798516784221, |
| "source_profile_identity_proven": true |
| }, |
| "view_B_batch_weighted": { |
| "control_mean_matrix_rank": 267, |
| "coordinate_variance_mean": 2.9616065717047468e-05, |
| "distinct_control_mixture_profile_fraction": 1.0, |
| "distinct_control_mixture_profiles": 9205, |
| "distinct_source_expression_profile_fraction": 1.0, |
| "distinct_source_expression_profiles_float32": 9205, |
| "max_perturbations_per_control_mixture": 1, |
| "queries": 9205, |
| "sample_pair_count": 9998, |
| "sample_pair_max_l2_distance": 2.2753692170298243, |
| "sample_pair_mean_l2_distance": 0.6546830657966001, |
| "sample_pair_median_l2_distance": 0.6043989240791572, |
| "source_profile_identity_proven": true |
| } |
| }, |
| "status": "GATE_1_PASS_PAIRING_SEMANTICS_RESOLVED", |
| "tolerance": { |
| "atol": 1e-05, |
| "rtol": 1e-05 |
| } |
| } |
|
|
