qa_id stringlengths 24 32 | question stringlengths 156 1.14k | answer stringlengths 3 134 | level stringclasses 1
value | subtype stringclasses 3
values | source_medium_qa_id stringclasses 1
value | record_json stringlengths 13.6k 214k |
|---|---|---|---|---|---|---|
medium_convergence_01763 | ATM and BRCA1 each interact with a shared protein partner. Evidence concerning one such shared partner states: 'We report the identification of receptor-associated protein 80 (a BRCA1-interacting protein) as a BRCA1-interacting protein in humans.' Which protein is encoded by the gene corresponding to this shared partne... | BRCA1-A complex subunit RAP80 | Medium | convergence | {"qa_id":"medium_convergence_01763","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATM and BRCA1 each interact with a shared protein partner. Evidence concerning one such shared partner states: 'We report the identification of receptor-asso... | |
medium_convergence_01764 | HDAC6 and HSF1 both interact with a specific protein. A study comparing the relative interaction strength of HSP90α and HSP90β with various partners explicitly lists this protein as a transcription factor alongside HIF1α. Which protein is encoded by the gene corresponding to this shared interaction partner? | Heat shock protein HSP 90-beta | Medium | convergence | {"qa_id":"medium_convergence_01764","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC6 and HSF1 both interact with a specific protein. A study comparing the relative interaction strength of HSP90α and HSP90β with various partners explicit... | |
medium_convergence_01765 | MAP3K2 and TRIM32 share a common interacting partner. Evidence indicates that this shared partner interacts with and ubiquitinates MEKK2, a kinase previously associated with bi-phasic NF-kappaB activation. Which protein is encoded by this shared partner? | E3 ubiquitin-protein ligase XIAP | Medium | convergence | {"qa_id":"medium_convergence_01765","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAP3K2 and TRIM32 share a common interacting partner. Evidence indicates that this shared partner interacts with and ubiquitinates MEKK2, a kinase previously... | |
medium_convergence_01766 | VPS28 and UBC each interact with more than one shared protein. Evidence concerning one shared entity reports that TSG101 and VPS28 co-immunoprecipitated with this entity-FLAG, and the three proteins comigrated together in soluble complexes of the correct size for human ESCRT-I (approximately 350 kDa). Which protein is ... | Vacuolar protein sorting-associated protein 37B | Medium | convergence | {"qa_id":"medium_convergence_01766","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"VPS28 and UBC each interact with more than one shared protein. Evidence concerning one shared entity reports that TSG101 and VPS28 co-immunoprecipitated with... | |
medium_convergence_01767 | FOXF2 and TGFBR2 are both involved in multiple shared biological processes. One of these shared processes is supported by evidence stating that the expression profiles of FOXF1 and this process suggest a functional role. Which biological process is this, and what is its parent term in the 'is_a' hierarchy? | mesenchymal cell differentiation | Medium | convergence | {"qa_id":"medium_convergence_01767","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FOXF2 and TGFBR2 are both involved in multiple shared biological processes. One of these shared processes is supported by evidence stating that the expressio... | |
medium_convergence_01768 | EP300 and GSK3B each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'We demonstrate that the lysine acetyltransferase p300 targets this entity at K40 for acetylation, which is counteracted by the deacetylase sirtuin 3 (SIRT3).' Which protein is encoded by that entity? | Induced myeloid leukemia cell differentiation protein Mcl-1 | Medium | convergence | {"qa_id":"medium_convergence_01768","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and GSK3B each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'We demonstrate that the lysine acetyltr... | |
medium_convergence_01769 | CTBP1 and CTNNB1 share a common interaction partner. Evidence regarding this shared partner indicates that Polycomb group proteins HPC2 and BMI-1, along with the corepressor C-terminal-binding protein, bind to the repression domain of this partner. Which cell type is enriched for this shared interaction partner? | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_01769","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTBP1 and CTNNB1 share a common interaction partner. Evidence regarding this shared partner indicates that Polycomb group proteins HPC2 and BMI-1, along with... | |
medium_convergence_01770 | IKZF1 and IKZF3 share common protein interaction partners. One such shared partner was identified in an unbiased mass spectrometry screen as a Runt-related transcription factor. Which protein is encoded by the gene corresponding to this shared interaction partner? | Runt-related transcription factor 1 | Medium | convergence | {"qa_id":"medium_convergence_01770","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IKZF1 and IKZF3 share common protein interaction partners. One such shared partner was identified in an unbiased mass spectrometry screen as a Runt-related t... | |
medium_convergence_01771 | FRS2 and ARHGAP5 both interact with a specific protein that is a member of the Rnd family. Evidence indicates that p190 RhoGAP (p190), the most abundant GAP for RhoA, interacts with Rnd proteins, and this interaction is mediated by a region of p190 distinct from its GAP domain. Which protein product is encoded by this ... | Rho-related GTP-binding protein RhoN | Medium | convergence | {"qa_id":"medium_convergence_01771","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FRS2 and ARHGAP5 both interact with a specific protein that is a member of the Rnd family. Evidence indicates that p190 RhoGAP (p190), the most abundant GAP ... | |
medium_convergence_01772 | ALK and GSK3B share multiple interacting partners. One such shared partner is physically associated with endogenous GSK3 beta in HEK293 cells, as demonstrated by co-immunoprecipitation analysis revealing an interaction with a specific kinase. Which protein is encoded by this shared interacting partner? | Mitogen-activated protein kinase kinase kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_01772","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ALK and GSK3B share multiple interacting partners. One such shared partner is physically associated with endogenous GSK3 beta in HEK293 cells, as demonstrate... | |
medium_convergence_01773 | Both Influenza A virus and Human mastadenovirus C are known to upregulate a specific shared gene. Experimental data for this gene indicates a log2 fold change of approximately 1.04 and an adjusted p-value of 0.00151. In which cell type is this gene reported to be enriched? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_01773","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Human mastadenovirus C are known to upregulate a specific shared gene. Experimental data for this gene indicates a log2 fold chang... | |
medium_convergence_01774 | NUDC and HSPH1 share multiple interacting partners. One specific shared partner is supported by evidence stating: 'Interaction of the two factors was identified by interactome analysis and structurally determined by X-ray crystallography and NMR analyses.' Which protein encodes this specific shared partner? | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 | Medium | convergence | {"qa_id":"medium_convergence_01774","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NUDC and HSPH1 share multiple interacting partners. One specific shared partner is supported by evidence stating: 'Interaction of the two factors was identif... | |
medium_convergence_01775 | Morphine and Triprolidine both interact with a specific drug. Evidence regarding this shared drug states: 'A recent study from our laboratory shows that rewarding effects of morphine are inhibited in rats co-treated with this drug.' Which disease is this drug indicated for? | anxiety | Medium | convergence | {"qa_id":"medium_convergence_01775","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Morphine and Triprolidine both interact with a specific drug. Evidence regarding this shared drug states: 'A recent study from our laboratory shows that rewa... | |
medium_convergence_01776 | Dicoumarol and Bexarotene share a common interacting drug. Evidence indicates that the combination of low doses of this shared drug and Bexarotene significantly suppressed the progression of colonic adenomas to adenocarcinomas. Which disease is this shared drug indicated for? | osteoporosis | Medium | convergence | {"qa_id":"medium_convergence_01776","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dicoumarol and Bexarotene share a common interacting drug. Evidence indicates that the combination of low doses of this shared drug and Bexarotene significan... | |
medium_convergence_01777 | PTPRF and RAC1 both interact with a specific shared protein. Evidence regarding this protein notes that, in contrast to other substrates, it (along with KRas and RhoA) binds to a guanine nucleotide dissociation stimulator in both active and inactive forms, a process requiring poly-basic residues in the C-termini of the... | T-cell adult acute lymphocytic leukemia | Medium | convergence | {"qa_id":"medium_convergence_01777","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PTPRF and RAC1 both interact with a specific shared protein. Evidence regarding this protein notes that, in contrast to other substrates, it (along with KRas... | |
medium_convergence_01778 | CREBBP and CCDC22 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In the mammalian two-hybrid system, CAD and NAD baits enhanced the luciferase expression from a reporter gene by co-transfection with CREB-binding protein (CBP) prey, whereas CAD, but not NAD, enhanced bet... | Hypoxia-inducible factor 1-alpha | Medium | convergence | {"qa_id":"medium_convergence_01778","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and CCDC22 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In the mammalian two-hybrid system, CAD an... | |
medium_convergence_01779 | CENPO and AURKB each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Approximately half of Aurora B in mitotic cells is complexed with this entity, Borealin, and Survivin; and Borealin binds Survivin and this entity in vitro.' Which disease is associated with this entity? | invasive carcinoma | Medium | convergence | {"qa_id":"medium_convergence_01779","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPO and AURKB each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Approximately half of Aurora B in mitotic ce... | |
medium_convergence_01780 | AKT1 and AKT2 both interact with a specific protein. Evidence regarding this interaction states: 'We show that the interaction of [the interacting partner] with Akt is mediated by the CAP-Gly domain of [the interacting partner] and kinase domain of Akt and is regulated by Akt phosphorylation.' Which protein is encoded ... | CAP-Gly domain-containing linker protein 3 | Medium | convergence | {"qa_id":"medium_convergence_01780","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKT1 and AKT2 both interact with a specific protein. Evidence regarding this interaction states: 'We show that the interaction of [the interacting partner] w... | |
medium_convergence_01781 | Both Human alphaherpesvirus 1 and Zaire ebolavirus are known to downregulate the expression of a specific gene. In a study using a monocytic leukemia cell line (GSE114966), the downregulation of this gene was associated with a log2 fold change of approximately -1.675 and an adjusted p-value of 0.0011. Which protein is ... | Plexin domain-containing protein 2 | Medium | convergence | {"qa_id":"medium_convergence_01781","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Zaire ebolavirus are known to downregulate the expression of a specific gene. In a study using a monocytic leukemia cell li... | |
medium_convergence_01782 | ARL1 and COG8 share a common binding partner. Evidence indicates that the GTP-bound form of this shared partner interacts with the GRIP domains of Golgin-97 and Golgin-245, a process dependent on conserved residues within those GRIP domains that are critical for Golgi targeting. Which protein is encoded by this shared ... | GRIP and coiled-coil domain-containing protein 2 | Medium | convergence | {"qa_id":"medium_convergence_01782","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARL1 and COG8 share a common binding partner. Evidence indicates that the GTP-bound form of this shared partner interacts with the GRIP domains of Golgin-97 ... | |
medium_convergence_01783 | Human respirovirus 3 and Severe acute respiratory syndrome-related coronavirus both upregulate a specific gene. Evidence for this gene in a non-small cell lung adenocarcinoma cell line (study GSE147507) reports a log2 fold change of approximately 1.148 and an adjusted p-value of 0.04933. Which disease is associated wit... | schizophrenia | Medium | convergence | {"qa_id":"medium_convergence_01783","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human respirovirus 3 and Severe acute respiratory syndrome-related coronavirus both upregulate a specific gene. Evidence for this gene in a non-small cell lu... | |
medium_convergence_01784 | PARP1 and MRE11A share multiple interacting partners. One such shared partner has been shown to interact with MRE11 to promote the formation of the MRE11-RAD50-NBS1 (MRN) complex, thereby facilitating the activation of the homologous recombination (HR) pathway. This mechanism mediates DNA damage tolerance and is associ... | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_01784","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and MRE11A share multiple interacting partners. One such shared partner has been shown to interact with MRE11 to promote the formation of the MRE11-RAD... | |
medium_convergence_01785 | Rhinovirus A and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (study GSE106475) reports a log2 fold change of approximately 1.298 and an adjusted p-value of 0.01807. Which cellular component is this gene located in? | epsilon DNA polymerase complex | Medium | convergence | {"qa_id":"medium_convergence_01785","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (study GSE106475) reports a log... | |
medium_convergence_01786 | CHMP4B and EGFR share a common interacting partner. Experimental evidence indicates that in a yeast two-hybrid assay, a specific protein tyrosine phosphatase showed positive interactions with this shared entity (also known as Shax1), TSG101, endophilin A1, and ALG-2, but not with RabGAPLP or CIN85. Which protein is enc... | Tyrosine-protein phosphatase non-receptor type 23 | Medium | convergence | {"qa_id":"medium_convergence_01786","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHMP4B and EGFR share a common interacting partner. Experimental evidence indicates that in a yeast two-hybrid assay, a specific protein tyrosine phosphatase... | |
medium_convergence_01787 | CENPE and COPB1 both interact with a shared protein partner. Evidence regarding this partner states: 'Herein we describe isolation of a subcomplex of coatomer consisting of beta- and delta-COPs that is able to bind to Golgi membranes in an ARF1- and GTP-dependent manner.' Which cellular component is this shared partner... | Golgi membrane | Medium | convergence | {"qa_id":"medium_convergence_01787","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPE and COPB1 both interact with a shared protein partner. Evidence regarding this partner states: 'Herein we describe isolation of a subcomplex of coatome... | |
medium_convergence_01788 | ARHGEF6 and CDC42 both interact with a common protein partner. Experimental evidence indicates that this partner binds strongly to GTP-Cdc42 and weakly to GTP-Rac. Which protein is encoded by the gene corresponding to this partner? | Serine/threonine-protein kinase PAK 6 | Medium | convergence | {"qa_id":"medium_convergence_01788","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARHGEF6 and CDC42 both interact with a common protein partner. Experimental evidence indicates that this partner binds strongly to GTP-Cdc42 and weakly to GT... | |
medium_convergence_01790 | DTX4 and RIPK1 share multiple binding partners. One shared partner is degraded via Lys48-linked polyubiquitination at Lys670, a process mediated by NLRP4 recruiting the E3 ubiquitin ligase DTX4 to this partner. Which disease is associated with this partner as a biomarker? | myelofibrosis | Medium | convergence | {"qa_id":"medium_convergence_01790","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DTX4 and RIPK1 share multiple binding partners. One shared partner is degraded via Lys48-linked polyubiquitination at Lys670, a process mediated by NLRP4 rec... | |
medium_convergence_01791 | HLA-A and HLA-E both interact with a specific protein complex involved in antigen processing. A study highlights that the T134K variant's inefficiency in presenting intracellular antigens is due to its failure to interact with the TAP heterodimer. Which disease is associated with this TAP-related entity as a biomarker? | glaucoma | Medium | convergence | {"qa_id":"medium_convergence_01791","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HLA-A and HLA-E both interact with a specific protein complex involved in antigen processing. A study highlights that the T134K variant's inefficiency in pre... | |
medium_convergence_01792 | BCL6 and TP53 share a common interacting partner. Evidence indicates that this shared partner directly interacts with p53 and stabilizes it via the ubiquitination pathway. Which protein is encoded by this shared partner? | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | Medium | convergence | {"qa_id":"medium_convergence_01792","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BCL6 and TP53 share a common interacting partner. Evidence indicates that this shared partner directly interacts with p53 and stabilizes it via the ubiquitin... | |
medium_convergence_01793 | CHEK1 and ATRIP both interact with a shared protein. Evidence indicates that this protein localizes to the nucleus but only associates with Chk1 following replication stress or other types of DNA damage. Which disease is associated with this protein? | telangiectasis | Medium | convergence | {"qa_id":"medium_convergence_01793","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK1 and ATRIP both interact with a shared protein. Evidence indicates that this protein localizes to the nucleus but only associates with Chk1 following re... | |
medium_convergence_01794 | RFC3 and RPA1 both interact with a specific protein. Experimental evidence indicates that for this protein, the binding motif is located within amino acids 100-300 and overlaps with the single-stranded DNA binding domain (amino acids 150-450), as determined by ELISA using deletion mutants. Which protein is this? | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN | Medium | convergence | {"qa_id":"medium_convergence_01794","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RFC3 and RPA1 both interact with a specific protein. Experimental evidence indicates that for this protein, the binding motif is located within amino acids 1... | |
medium_convergence_01795 | COMMD1 and VPS29 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Here we report that COMMD1 is directly linked to early endosomes through its interaction with a protein complex containing CCDC22, CCDC93, and this shared entity.' Which protein is connected to that en... | VPS35 endosomal protein-sorting factor-like | Medium | convergence | {"qa_id":"medium_convergence_01795","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COMMD1 and VPS29 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Here we report that COMMD1 is directly... | |
medium_convergence_01796 | Both Dengue virus and Enterovirus A are known to upregulate a specific host gene. Experimental data from a hepatoma cell line study (GSE110512) indicates that this shared target exhibits a log2 fold change of approximately 1.28 and an adjusted p-value of 0.006557. Which biological process is this gene involved in? | tRNA dihydrouridine synthesis | Medium | convergence | {"qa_id":"medium_convergence_01796","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Dengue virus and Enterovirus A are known to upregulate a specific host gene. Experimental data from a hepatoma cell line study (GSE110512) indicates tha... | |
medium_convergence_01797 | EHMT2 and UHRF1 both interact with a specific shared protein. Evidence indicates that this protein contains a histone H3K9-like mimic that is methylated by G9a and GLP, and this methylated mimic binds UHRF1 more avidly than H3K9me2/3 does. Which protein is encoded by the gene corresponding to this shared entity? | DNA ligase 1 | Medium | convergence | {"qa_id":"medium_convergence_01797","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EHMT2 and UHRF1 both interact with a specific shared protein. Evidence indicates that this protein contains a histone H3K9-like mimic that is methylated by G... | |
medium_convergence_01798 | ARCN1 and COG1 share a common interacting partner. Evidence regarding this shared partner includes reports of immunoprecipitation and two-hybrid system analysis within a complete COP screen, demonstrating physical interactions between alpha- and epsilon-COPs, as well as between beta- and delta-COPs. Which protein is en... | Coatomer subunit beta | Medium | convergence | {"qa_id":"medium_convergence_01798","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARCN1 and COG1 share a common interacting partner. Evidence regarding this shared partner includes reports of immunoprecipitation and two-hybrid system analy... | |
medium_convergence_01799 | IKZF1 and PRMT5 share common interaction partners. One such partner is described in evidence stating that Ikaros and its repression domains interact in vivo and in vitro with the mSin3 family of co-repressors, which bind to histone deacetylases. Which protein is connected to this specific entity through the 'encodes' r... | Paired amphipathic helix protein Sin3a | Medium | convergence | {"qa_id":"medium_convergence_01799","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IKZF1 and PRMT5 share common interaction partners. One such partner is described in evidence stating that Ikaros and its repression domains interact in vivo ... | |
medium_convergence_01800 | Both the transitional myocyte of the atrioventricular bundle and the Purkinje myocyte of the atrioventricular bundle are subtypes of a specific cell type. Evidence indicates that a transitional myocyte is part of the atrioventricular bundle. Which cell type is the parent class of this transitional myocyte? | His-Purkinje system cell | Medium | convergence | {"qa_id":"medium_convergence_01800","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the transitional myocyte of the atrioventricular bundle and the Purkinje myocyte of the atrioventricular bundle are subtypes of a specific cell type. Ev... | |
medium_convergence_01801 | ERBB2 and HDAC1 share a common interacting partner. Evidence indicates that the c-erbB-2 gene product associates directly with both beta-catenin and plakoglobin through its cytoplasmic domain core region. Which protein is encoded by this shared interacting partner? | Junction plakoglobin | Medium | convergence | {"qa_id":"medium_convergence_01801","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB2 and HDAC1 share a common interacting partner. Evidence indicates that the c-erbB-2 gene product associates directly with both beta-catenin and plakoglo... | |
medium_convergence_01802 | RFC3 and RPA2 both interact with a shared protein partner. Evidence regarding one such partner states: 'We have solved the high-resolution crystal structure of RPA32 C-terminal domain (RPA32C) in complex with a 26-amino-acid peptide derived from the N-terminus of this protein.' Which protein is encoded by the gene corr... | SNF2 related chromatin remodeling annealing helicase 1 | Medium | convergence | {"qa_id":"medium_convergence_01802","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RFC3 and RPA2 both interact with a shared protein partner. Evidence regarding one such partner states: 'We have solved the high-resolution crystal structure ... | |
medium_convergence_01803 | CRK and EGFR share multiple interacting partners. One such shared partner is recruited to EGFRvIII and inhibits the transformation of NIH 3T3 cells by EGFRvIII. Which disease is connected to this specific shared partner through genomic alterations? | systemic lupus erythematosus | Medium | convergence | {"qa_id":"medium_convergence_01803","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRK and EGFR share multiple interacting partners. One such shared partner is recruited to EGFRvIII and inhibits the transformation of NIH 3T3 cells by EGFRvI... | |
medium_convergence_01804 | Interferon beta-1b and Cyclosporine both interact with a specific drug. Evidence regarding this drug states: 'These effects of cyclosporine and gemfibrozil explain the increased plasma statin concentrations and, together with pharmacodynamic factors, the increased risk of myotoxicity when coadministered with statins.' ... | Familial type 3 hyperlipoproteinemia | Medium | convergence | {"qa_id":"medium_convergence_01804","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Interferon beta-1b and Cyclosporine both interact with a specific drug. Evidence regarding this drug states: 'These effects of cyclosporine and gemfibrozil e... | |
medium_convergence_01805 | EHMT2 and CTBP1 both interact with a specific shared protein. Evidence regarding this protein states: 'We purified a complex of nuclear [protein]-binding proteins by affinity chromatography and identified its components by mass spectrometry as Jarid1b/Plu-1, G9a, LSD1, CoREST and [protein].' Which disease is associated... | melanoma | Medium | convergence | {"qa_id":"medium_convergence_01805","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EHMT2 and CTBP1 both interact with a specific shared protein. Evidence regarding this protein states: 'We purified a complex of nuclear [protein]-binding pro... | |
medium_convergence_01806 | HDAC1 and C11orf30 share multiple interacting partners. One such shared partner is described in evidence stating: 'Recent work from others and us revealed interactions between the Sin3/HDAC complex, the H3K4me3 demethylase [Entity], GATAD1, and EMSY.' Which protein is encoded by this [Entity]? | Lysine-specific demethylase 5A | Medium | convergence | {"qa_id":"medium_convergence_01806","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and C11orf30 share multiple interacting partners. One such shared partner is described in evidence stating: 'Recent work from others and us revealed in... | |
medium_convergence_01807 | The vasculature of the cerebellum and the vasculature of the brain share a common anatomical superclass. Evidence regarding one such shared entity describes it as a 'System pertaining to blood vessels in the brain.' Which anatomical structure is this shared entity a part of? | central nervous system | Medium | convergence | {"qa_id":"medium_convergence_01807","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The vasculature of the cerebellum and the vasculature of the brain share a common anatomical superclass. Evidence regarding one such shared entity describes ... | |
medium_convergence_01808 | FAF2 and VCP share interaction partners. One such shared partner is described in evidence stating: 'We clarified that [the shared partner], an essential factor in both p97 membrane fusion pathways, is phosphorylated on Threonine-760 and Serine-767 by Cdc2 at mitosis and that this phosphorylated [shared partner] does no... | Deubiquitinating protein VCPIP1 | Medium | convergence | {"qa_id":"medium_convergence_01808","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FAF2 and VCP share interaction partners. One such shared partner is described in evidence stating: 'We clarified that [the shared partner], an essential fact... | |
medium_convergence_01809 | BCAP31 and SEC61B share a common interaction partner. Evidence indicates that this partner, along with BAP31, is an ER-resident membrane protein that binds mIg molecules. Which biological process is this shared partner involved in? | osteoblast differentiation | Medium | convergence | {"qa_id":"medium_convergence_01809","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BCAP31 and SEC61B share a common interaction partner. Evidence indicates that this partner, along with BAP31, is an ER-resident membrane protein that binds m... | |
medium_convergence_01810 | Both Human alphaherpesvirus 3 and Zika virus are reported to downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) shows a log2 fold change of approximately -1.003 and an adjusted p-value of 2.329e-08. Which protein is encoded by this gene? | DNA-directed RNA polymerases I and III subunit RPAC1 | Medium | convergence | {"qa_id":"medium_convergence_01810","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Zika virus are reported to downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE... | |
medium_convergence_01811 | CLTC and EGFR share interaction partners. One such partner is described in evidence stating: 'We show that the ESCRT accessory protein [ENTITY] associates with EGFR and combines with the deubiquitinating enzyme UBPY/USP8 to transfer EGFR from ESCRT-0 to ESCRT-III and drive EGFR sorting to intralumenal vesicles.' Which ... | Tyrosine-protein phosphatase non-receptor type 23 | Medium | convergence | {"qa_id":"medium_convergence_01811","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CLTC and EGFR share interaction partners. One such partner is described in evidence stating: 'We show that the ESCRT accessory protein [ENTITY] associates wi... | |
medium_convergence_01812 | CTNNB1 and YWHAH share multiple interacting partners. One such partner is identified by evidence stating: 'Co-immunoprecipitation experiments revealed that both endogenous and epitope-tagged deletion mutants of lp-dlg associated with beta-catenin.' Which disease is connected to this specific entity through a biomarker ... | multiloculated renal cyst | Medium | convergence | {"qa_id":"medium_convergence_01812","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and YWHAH share multiple interacting partners. One such partner is identified by evidence stating: 'Co-immunoprecipitation experiments revealed that b... | |
medium_convergence_01813 | ACVR2A and ACVR2B each interact with more than one shared ligand. Evidence concerning one such shared ligand states: 'We hypothesized that, in addition to its canonical receptor ACVR2, activin A might similarly bind and signal via BMPR2.' Which protein is encoded by the gene corresponding to that ligand? | Inhibin beta A chain | Medium | convergence | {"qa_id":"medium_convergence_01813","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACVR2A and ACVR2B each interact with more than one shared ligand. Evidence concerning one such shared ligand states: 'We hypothesized that, in addition to it... | |
medium_convergence_01814 | Both TNK2 and DNM1 interact with a shared protein. Experimental evidence regarding this shared protein states: 'By testing the association of various truncations of ACK1 with this protein we confirmed the dominant binding domain in human ACK1 (residues 920-955).' Which protein is encoded by this shared entity? | Sorting nexin-9 | Medium | convergence | {"qa_id":"medium_convergence_01814","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both TNK2 and DNM1 interact with a shared protein. Experimental evidence regarding this shared protein states: 'By testing the association of various truncat... | |
medium_convergence_01815 | RUVBL2 and ZNHIT2 both interact with a specific shared protein. Evidence indicates that Reptin, a highly conserved AAA+ ATPase involved in chromatin-remodeling complexes, associates with this shared protein, as demonstrated by immunoprecipitation and confocal microscopic analysis. Which protein is encoded by this share... | RNA polymerase II-associated protein 3 | Medium | convergence | {"qa_id":"medium_convergence_01815","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RUVBL2 and ZNHIT2 both interact with a specific shared protein. Evidence indicates that Reptin, a highly conserved AAA+ ATPase involved in chromatin-remodeli... | |
medium_convergence_01816 | ERBB2 and FGFR1 share a common interaction partner. Experimental evidence indicates that FRS2 co-immunoprecipitates with this shared partner in a complex that requires FGFR1. Specifically, both the extracellular and intracellular domains of FGFR1 are required for its association with the shared partner, while the cytop... | Platelet-derived growth factor receptor beta | Medium | convergence | {"qa_id":"medium_convergence_01816","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB2 and FGFR1 share a common interaction partner. Experimental evidence indicates that FRS2 co-immunoprecipitates with this shared partner in a complex tha... | |
medium_convergence_01817 | CSNK2A2 and HSP90AA1 share multiple interacting partners. One such partner is implicated in a study demonstrating that in human melanoma cells, two isoforms of a cyclin-dependent kinase interact with Hsp90 and its co-chaperone cdc37. Which protein is encoded by the gene corresponding to this shared interacting partner? | Cyclin-dependent kinase 11B | Medium | convergence | {"qa_id":"medium_convergence_01817","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2A2 and HSP90AA1 share multiple interacting partners. One such partner is implicated in a study demonstrating that in human melanoma cells, two isoforms ... | |
medium_convergence_01818 | SFN and YWHAG both interact with a shared gene. Evidence for one such shared partner states: 'We demonstrate direct and robust interaction between hEXO1 and six of the seven 14-3-3 isoforms in vitro, suggestive of a novel protein interaction network between DNA repair and cell cycle control.' Which gene interacts with ... | DCAF1 | Medium | convergence | {"qa_id":"medium_convergence_01818","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SFN and YWHAG both interact with a shared gene. Evidence for one such shared partner states: 'We demonstrate direct and robust interaction between hEXO1 and ... | |
medium_convergence_01819 | Dengue virus and Enterovirus A both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold change of -1.861 and an adjusted p-value of 0.0422. What molecular function is enabled by the protein product of this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_01819","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Enterovirus A both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fo... | |
medium_convergence_01820 | MAP3K7 and CARD11 both interact with a specific protein kinase. Evidence indicates that this kinase, along with PKCbeta, phosphorylates identical serine residues (S564, S649, and S657) within the serine-rich linker of CARMA1. Which protein is encoded by the gene corresponding to this kinase? | Protein kinase C theta type | Medium | convergence | {"qa_id":"medium_convergence_01820","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAP3K7 and CARD11 both interact with a specific protein kinase. Evidence indicates that this kinase, along with PKCbeta, phosphorylates identical serine resi... | |
medium_convergence_01821 | EP300 and ESR1 both interact with a shared protein. Evidence indicates that this shared protein is acetylated at Lysine 160 by the acetyltransferase p300/CREB binding protein (CBP) through direct protein interaction, a process that stimulates the acetylation and catalytic activity of p300/CBP. Which protein is encoded ... | Glyceraldehyde-3-phosphate dehydrogenase | Medium | convergence | {"qa_id":"medium_convergence_01821","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and ESR1 both interact with a shared protein. Evidence indicates that this shared protein is acetylated at Lysine 160 by the acetyltransferase p300/CRE... | |
medium_convergence_01822 | Both Human immunodeficiency virus 1 and Dengue virus are associated with the downregulation of a specific gene. Experimental data from a study on macrophages (GSE108897) indicates that this gene exhibits a log2 fold change of -1.963 and an adjusted p-value of 1.658e-05. Which protein is encoded by this gene? | Gamma-adducin | Medium | convergence | {"qa_id":"medium_convergence_01822","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus are associated with the downregulation of a specific gene. Experimental data from a study on macrophages... | |
medium_convergence_01823 | UBC and CHMP6 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Crystallographic and biochemical analyses reveal that the GLUE domain of the human ESCRT-II subunit (also called this protein) is a split pleckstrin-homology domain that binds ubiquitin along one edge of the b... | Vacuolar protein-sorting-associated protein 36 | Medium | convergence | {"qa_id":"medium_convergence_01823","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBC and CHMP6 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Crystallographic and biochemical analyses reve... | |
medium_convergence_01824 | DSG4 and DSP each interact with more than one shared protein partner. Evidence concerning one such shared partner reports: 'In extracts from HaCaT cells, distinct soluble complexes containing PKP1a and desmoplakin I (DPI) have been identified by co-immunoprecipitation and sucrose density fractionation.' Which protein i... | Plakophilin-1 | Medium | convergence | {"qa_id":"medium_convergence_01824","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DSG4 and DSP each interact with more than one shared protein partner. Evidence concerning one such shared partner reports: 'In extracts from HaCaT cells, dis... | |
medium_convergence_01825 | YAP1 and PARK7 share multiple interacting partners. One such shared partner is described in evidence stating that a kinase physically interacts with YAP and counteracts CK1δ/ε-mediated YAP ubiquitination and degradation independent of LATS1/2. Which protein is encoded by the gene corresponding to this shared partner? | MAP kinase-activated protein kinase 5 | Medium | convergence | {"qa_id":"medium_convergence_01825","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and PARK7 share multiple interacting partners. One such shared partner is described in evidence stating that a kinase physically interacts with YAP and ... | |
medium_convergence_01826 | BMP2 and BMP5 each interact with multiple shared receptors. One such shared receptor is described as a transmembrane serine/threonine kinase that binds BMP-2 and BMP-7 in association with multiple type I receptors, including BMPR-IA/Brk1, BMPR-IB, and ActR-I. Which disease is associated with this specific receptor as a... | anemia due to chronic disorder | Medium | convergence | {"qa_id":"medium_convergence_01826","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMP2 and BMP5 each interact with multiple shared receptors. One such shared receptor is described as a transmembrane serine/threonine kinase that binds BMP-2... | |
medium_convergence_01827 | H2AX and TP53 share common interacting partners. One such shared partner is described in the following context: 'Here, we show that this protein co-localizes and associates with gamma H2AX, a marker protein of DNA double strand breaks (DSBs), after cellular exposure to gamma-irradiation.' Which protein is encoded by th... | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN | Medium | convergence | {"qa_id":"medium_convergence_01827","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"H2AX and TP53 share common interacting partners. One such shared partner is described in the following context: 'Here, we show that this protein co-localizes... | |
medium_convergence_01828 | ATF2 and IKBKE both interact with a shared transcription factor. Evidence indicates that the viral protein NS7a interacts simultaneously with the kinase domain and the scaffold dimerization domain of IKKε, competing with TRAF3 and this specific transcription factor for binding to IKKε, which leads to the reduction of R... | regulatory T cell | Medium | convergence | {"qa_id":"medium_convergence_01828","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATF2 and IKBKE both interact with a shared transcription factor. Evidence indicates that the viral protein NS7a interacts simultaneously with the kinase doma... | |
medium_convergence_01829 | CLTC and DNAJC6 share multiple binding partners. One shared partner is identified by evidence stating: 'In vitro binding and coimmunoprecipitation demonstrated that the clathrin heavy chain is the major binding partner of this protein.' Which disease is associated with this specific shared partner via a biomarker relat... | paroxysmal familial ventricular fibrillation | Medium | convergence | {"qa_id":"medium_convergence_01829","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CLTC and DNAJC6 share multiple binding partners. One shared partner is identified by evidence stating: 'In vitro binding and coimmunoprecipitation demonstrat... | |
medium_convergence_01830 | ACAD9 and COA1 both interact with a shared protein. Evidence indicates that this shared protein is a complex I assembly factor and is specifically required for the assembly of complex I. Which disease is associated with this protein? | mitochondrial complex I deficiency, nuclear type 11 | Medium | convergence | {"qa_id":"medium_convergence_01830","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACAD9 and COA1 both interact with a shared protein. Evidence indicates that this shared protein is a complex I assembly factor and is specifically required f... | |
medium_convergence_01831 | EDN1 and HRAS both interact with a common downstream signaling protein. Evidence indicates that the transforming activity of Ras correlates most strongly with the ability of the encoded protein to interact with this shared protein. Which cell type is this shared protein enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_01831","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EDN1 and HRAS both interact with a common downstream signaling protein. Evidence indicates that the transforming activity of Ras correlates most strongly wit... | |
medium_convergence_01832 | HDAC1 and H3C1 each bind to more than one shared gene. Evidence concerning one shared entity reports: 'An affinity-purified HDAC1 corepressor complex also contains this entity, suggesting that MeCP1 corresponds to a fraction of this complex.' Which gene is connected to this entity through 'interacts with'? | MTA1 | Medium | convergence | {"qa_id":"medium_convergence_01832","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and H3C1 each bind to more than one shared gene. Evidence concerning one shared entity reports: 'An affinity-purified HDAC1 corepressor complex also co... | |
medium_convergence_01833 | BRD4 and PCNA both interact with a specific shared protein. Evidence regarding this shared protein states: 'In vitro biochemical analysis demonstrated that these two proteins associate directly, with the interaction being mediated by residues between amino acids 166 and 310 of this protein.' Which gene encodes this sha... | DNA repair protein XRCC1 | Medium | convergence | {"qa_id":"medium_convergence_01833","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD4 and PCNA both interact with a specific shared protein. Evidence regarding this shared protein states: 'In vitro biochemical analysis demonstrated that t... | |
medium_convergence_01834 | Liothyronine and Betamethasone share a common interacting drug. Clinical evidence regarding this shared drug indicates that the effect of combination therapy on sexual function correlated with a treatment-induced increase in serum levels of free triiodothyronine and this specific drug. Which disease is this shared drug... | hypogonadotropic hypogonadism | Medium | convergence | {"qa_id":"medium_convergence_01834","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Liothyronine and Betamethasone share a common interacting drug. Clinical evidence regarding this shared drug indicates that the effect of combination therapy... | |
medium_convergence_01835 | VEGFB and CBL share common binding partners. One such partner is described in evidence stating: 'Here by using in vitro and in vivo binding assays, we show that the Casitas B-lineage lymphoma (c-Cbl) E3 ubiquitin ligase constitutively associates with PLCgamma1 via its C-terminal domain and conditionally interacts with ... | Vascular endothelial growth factor receptor 2 | Medium | convergence | {"qa_id":"medium_convergence_01835","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"VEGFB and CBL share common binding partners. One such partner is described in evidence stating: 'Here by using in vitro and in vivo binding assays, we show t... | |
medium_convergence_01836 | B9D2 and AURKB each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here we report the identification of Dasra A and Dasra B, two new components of the vertebrate chromosomal passenger complex containing Incenp, Survivin, and the kinase Aurora B, and demonstrate that this com... | Borealin | Medium | convergence | {"qa_id":"medium_convergence_01836","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"B9D2 and AURKB each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here we report the identification of Dasra A ... | |
medium_convergence_01837 | CDK5RAP2 and CDK1 both interact with a specific centrosomal protein. Evidence indicates that this protein binds to and recruits CDK1 to centrosomes, thereby regulating mitotic entry. Which protein is encoded by the gene corresponding to this interacting entity? | Centrosomal protein of 63 kDa | Medium | convergence | {"qa_id":"medium_convergence_01837","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK5RAP2 and CDK1 both interact with a specific centrosomal protein. Evidence indicates that this protein binds to and recruits CDK1 to centrosomes, thereby ... | |
medium_convergence_01838 | Both Human betaherpesvirus 5 and Zaire ebolavirus are known to downregulate a specific shared gene. Experimental data from a study on foreskin fibroblast cell lines (GSE132081) indicates that for one such shared target, the log2 fold change is -1.682 and the adjusted p-value is 0.04463. Which cellular component is this... | plasma membrane | Medium | convergence | {"qa_id":"medium_convergence_01838","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human betaherpesvirus 5 and Zaire ebolavirus are known to downregulate a specific shared gene. Experimental data from a study on foreskin fibroblast cel... | |
medium_convergence_01839 | ASB13 and CUL5 each interact with more than one shared protein partner. Evidence concerning one such shared entity indicates that a RING-box protein forms an in vivo complex with Cul-5 and VHL under hypoxic conditions. Which protein is encoded by the gene corresponding to that shared entity? | RING-box protein 2 | Medium | convergence | {"qa_id":"medium_convergence_01839","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ASB13 and CUL5 each interact with more than one shared protein partner. Evidence concerning one such shared entity indicates that a RING-box protein forms an... | |
medium_convergence_01840 | Both Measles morbillivirus and Human mastadenovirus C are associated with the upregulation of a specific gene. Experimental data for this gene indicates a log2 fold change of approximately 2.32 and an adjusted p-value of 0.0205. Which protein is encoded by this gene? | Oxidative stress-responsive serine-rich protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01840","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Human mastadenovirus C are associated with the upregulation of a specific gene. Experimental data for this gene indicates a lo... | |
medium_convergence_01841 | Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line study (GSE11238) indicates that this gene has a log2 fold change of -1.143 and an adjusted p-value of 0.002805. Which disease is associated with this gene as a biomarker? | pneumonia | Medium | convergence | {"qa_id":"medium_convergence_01841","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line study (GSE11238) ind... | |
medium_convergence_01843 | Both Human alphaherpesvirus 3 and Human immunodeficiency virus 1 are known to downregulate a specific shared gene. Experimental data from a melanoma cell line study (GSE136586) indicates that this gene exhibits a log2 fold change of -1.374 and an adjusted p-value of 3.819e-05. Which disease is causally linked to this g... | retinal degeneration | Medium | convergence | {"qa_id":"medium_convergence_01843","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Human immunodeficiency virus 1 are known to downregulate a specific shared gene. Experimental data from a melanoma cell lin... | |
medium_convergence_01844 | Insulin glargine and Cyclosporine share a common drug interaction partner. Evidence regarding one such shared partner notes that twelve medications (sertraline, losartan, the shared partner, quinine, atorvastatin, simvastatin, pravastatin, fluvastatin, alendronate, digoxin, acyclovir, and oxycodone) were identified as ... | heart failure | Medium | convergence | {"qa_id":"medium_convergence_01844","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Insulin glargine and Cyclosporine share a common drug interaction partner. Evidence regarding one such shared partner notes that twelve medications (sertrali... | |
medium_convergence_01845 | Human alphaherpesvirus 1 and Cardiovirus A both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately -1.406 and an adjusted p-value of approximately 0.00355. Which disease is associated with this gene as a biomarker... | prostate cancer | Medium | convergence | {"qa_id":"medium_convergence_01845","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Cardiovirus A both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114... | |
medium_convergence_01846 | EP300 and TRIM33 both interact with a specific shared protein. Experimental evidence indicates that p300 coimmunoprecipitates with this protein in extracts from murine erythroleukemia (MEL) cells induced to differentiate with dimethylsulfoxide (DMSO), and that p300 and this protein are found together in a common E box ... | T-cell acute lymphocytic leukemia protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01846","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and TRIM33 both interact with a specific shared protein. Experimental evidence indicates that p300 coimmunoprecipitates with this protein in extracts f... | |
medium_convergence_01847 | ACTR2 and APOB both interact with a shared protein entity. Evidence regarding this entity states: 'The NTA region interacts directly with the Arp2/3 complex based on affinity chromatography, immunoprecipitation assays, and binding assays using purified components.' Which cell type is this shared entity enriched in? | peripheral blood mononuclear cell | Medium | convergence | {"qa_id":"medium_convergence_01847","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACTR2 and APOB both interact with a shared protein entity. Evidence regarding this entity states: 'The NTA region interacts directly with the Arp2/3 complex ... | |
medium_convergence_01848 | BRCA2 and BRIP1 both interact with a common protein partner. Evidence indicates that this shared partner independently interacts with BRCA1 via its NH2 terminus and with BRCA2 via its COOH terminus. Which protein is encoded by the gene corresponding to this shared partner? | Partner and localizer of BRCA2 | Medium | convergence | {"qa_id":"medium_convergence_01848","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRCA2 and BRIP1 both interact with a common protein partner. Evidence indicates that this shared partner independently interacts with BRCA1 via its NH2 termi... | |
medium_convergence_01850 | Human alphaherpesvirus 1 and Rift Valley fever phlebovirus both upregulate a specific gene. Experimental data for this gene in a foreskin fibroblast cell line (study GSE100576) reports a log2 fold change of approximately 1.555 and an adjusted p-value of approximately 0.0497. In which cell type is this gene enriched? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_01850","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Rift Valley fever phlebovirus both upregulate a specific gene. Experimental data for this gene in a foreskin fibroblast cell lin... | |
medium_convergence_01851 | Zaire ebolavirus and Human gammaherpesvirus 8 both downregulate a specific gene. In a study of retinal pigment epithelium cells (GSE100839), this gene showed a log2 fold change of approximately -1.100 and an adjusted p-value of 0.002666. Which protein is encoded by this gene? | Thiol S-methyltransferase TMT1B | Medium | convergence | {"qa_id":"medium_convergence_01851","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Zaire ebolavirus and Human gammaherpesvirus 8 both downregulate a specific gene. In a study of retinal pigment epithelium cells (GSE100839), this gene showed... | |
medium_convergence_01852 | Measles morbillivirus and Human orthopneumovirus both upregulate a specific gene. Evidence for this shared target reports a log2 fold change of 1.659 and an adjusted p-value of 0.002731. Which protein is encoded by this gene? | Zinc finger protein 821 | Medium | convergence | {"qa_id":"medium_convergence_01852","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Measles morbillivirus and Human orthopneumovirus both upregulate a specific gene. Evidence for this shared target reports a log2 fold change of 1.659 and an ... | |
medium_convergence_01853 | CDK7 and ERCC3 share common interaction partners. One such partner is identified by evidence stating: 'Protein affinity assays demonstrate that TFIIE binds directly to ERCC-3, a DNA repair protein associated with TFIIH.' Which protein product is encoded by the gene corresponding to this shared interaction partner? | General transcription factor IIE subunit 1 | Medium | convergence | {"qa_id":"medium_convergence_01853","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK7 and ERCC3 share common interaction partners. One such partner is identified by evidence stating: 'Protein affinity assays demonstrate that TFIIE binds d... | |
medium_convergence_01854 | FGF1 and FGF20 both interact with a specific receptor protein. Evidence regarding this receptor states: 'We have crystallized a complex between human FGF1 and a two-domain extracellular fragment of human [receptor].' Which protein is encoded by the gene corresponding to this receptor? | Fibroblast growth factor receptor 2 | Medium | convergence | {"qa_id":"medium_convergence_01854","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FGF1 and FGF20 both interact with a specific receptor protein. Evidence regarding this receptor states: 'We have crystallized a complex between human FGF1 an... | |
medium_convergence_01855 | Dengue virus and Enterovirus A both downregulate a specific gene in hepatoma cells. Experimental data from study GSE110512 indicates that for one such shared target, the log2 fold change is -1.929 and the adjusted p-value is 0.01795. Which protein is encoded by this gene? | Filamin A-interacting protein 1-like | Medium | convergence | {"qa_id":"medium_convergence_01855","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Enterovirus A both downregulate a specific gene in hepatoma cells. Experimental data from study GSE110512 indicates that for one such shared... | |
medium_convergence_01856 | MTOR and VPS33A share common interaction partners. One such shared partner is described by the following evidence: 'Under nutrient-enriched conditions, mTORC1 binds and phosphorylates this protein.' Which protein is encoded by this shared interaction partner? | UV radiation resistance-associated gene protein | Medium | convergence | {"qa_id":"medium_convergence_01856","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MTOR and VPS33A share common interaction partners. One such shared partner is described by the following evidence: 'Under nutrient-enriched conditions, mTORC... | |
medium_convergence_01857 | Both Human alphaherpesvirus 3 and Zika virus have been shown to downregulate a specific gene. Experimental data from a melanoma cell line study (GSE136586) indicates that for one such shared target, the log2 fold change is -1.258 and the adjusted p-value is 7.136e-05. Which disease is associated with this specific gene... | microcephaly 23, primary, autosomal recessive | Medium | convergence | {"qa_id":"medium_convergence_01857","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Zika virus have been shown to downregulate a specific gene. Experimental data from a melanoma cell line study (GSE136586) i... | |
medium_convergence_01858 | Bexarotene and Mefloquine share a common drug interaction partner. Clinical evidence regarding this shared partner indicates that its Cmax and systemic exposure were significantly reduced by 19-37% in the context of the interaction. Which disease is this shared drug indicated for? | HIV infectious disease | Medium | convergence | {"qa_id":"medium_convergence_01858","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Bexarotene and Mefloquine share a common drug interaction partner. Clinical evidence regarding this shared partner indicates that its Cmax and systemic expos... | |
medium_convergence_01859 | CDK5 and CSNK2A1 both interact with a specific shared gene. Evidence regarding this shared entity states: 'Using a chemical genetic approach, we identified Cdc25A, the shared entity and Cdc25C as direct Cdk5 substrates in mouse brain lysates.' Which disease is associated with this entity? | hyperplasia | Medium | convergence | {"qa_id":"medium_convergence_01859","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK5 and CSNK2A1 both interact with a specific shared gene. Evidence regarding this shared entity states: 'Using a chemical genetic approach, we identified C... | |
medium_convergence_01860 | GNAI2 and GNB3 both interact with a specific protein. Experimental evidence involving co-immunoprecipitation and bioluminescence resonance energy transfer (BRET) indicates that a splice variant of GNB3 (Gβ3s) fails to form complexes with Gγ or Gα subunits, unlike the canonical Gβ3. This evidence pertains to the interac... | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 | Medium | convergence | {"qa_id":"medium_convergence_01860","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNAI2 and GNB3 both interact with a specific protein. Experimental evidence involving co-immunoprecipitation and bioluminescence resonance energy transfer (B... | |
medium_convergence_01861 | RAD50 and MDC1 both interact with a shared protein. Evidence indicates that this shared protein facilitates the accumulation of checkpoint mediator proteins BRCA1 and 53BP1 at damaged chromatin, specifically through phospho-dependent binding via its FHA domain to MDC1. Which protein is encoded by the gene corresponding... | E3 ubiquitin-protein ligase RNF8 | Medium | convergence | {"qa_id":"medium_convergence_01861","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAD50 and MDC1 both interact with a shared protein. Evidence indicates that this shared protein facilitates the accumulation of checkpoint mediator proteins ... | |
medium_convergence_01862 | Both Human alphaherpesvirus 1 and Human polyomavirus 1 are reported to upregulate a specific gene. In a study using a monocytic leukemia cell line (GSE114966), the upregulation of this gene by these viruses was associated with a log2 fold change of approximately 1.14 and an adjusted p-value of approximately 0.015. Whic... | Ski oncogene | Medium | convergence | {"qa_id":"medium_convergence_01862","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Human polyomavirus 1 are reported to upregulate a specific gene. In a study using a monocytic leukemia cell line (GSE114966... | |
medium_convergence_01863 | YWHAQ and AKT1 share multiple interacting partners. One such shared partner was identified as a novel protein binding to PKB via a yeast two-hybrid screening system. Which disease is associated with this specific shared partner as a biomarker? | adenoviridae infectious disease | Medium | convergence | {"qa_id":"medium_convergence_01863","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAQ and AKT1 share multiple interacting partners. One such shared partner was identified as a novel protein binding to PKB via a yeast two-hybrid screening... | |
medium_convergence_01864 | CCDC22 and CUL1 share multiple binding partners. One such partner is characterized by proteomic analysis demonstrating interactions with Skp1, Cullin1, Ring-box1, and all components of the COP9 signalosome. Which disease is associated with this specific entity? | trisomy | Medium | convergence | {"qa_id":"medium_convergence_01864","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCDC22 and CUL1 share multiple binding partners. One such partner is characterized by proteomic analysis demonstrating interactions with Skp1, Cullin1, Ring-... | |
medium_convergence_01865 | Histamine secretion by platelets and protein secretion by platelets are both subtypes of a specific biological process. Evidence regarding one of these subtypes states: 'The regulated release of histamine by a platelet or group of platelets.' Which broader biological process, defined by this evidence, serves as the imm... | cellular process | Medium | convergence | {"qa_id":"medium_convergence_01865","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Histamine secretion by platelets and protein secretion by platelets are both subtypes of a specific biological process. Evidence regarding one of these subty... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.