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medium_convergence_01973 | LIG4 and APTX both interact with a shared protein partner. Evidence regarding one such partner notes that direct interactions between XLF/Nej1 and DNA ligase IV were observed, but these appeared qualitatively different from the stable coiled-coil-mediated interaction between this partner and DNA ligase IV. Which diseas... | schizophrenia | Medium | convergence | {"qa_id":"medium_convergence_01973","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LIG4 and APTX both interact with a shared protein partner. Evidence regarding one such partner notes that direct interactions between XLF/Nej1 and DNA ligase... | |
medium_convergence_01974 | EHMT2 and RCOR3 share multiple interacting partners. One such shared partner is described by the following evidence: 'Strikingly, we found that this protein binds to both SUV39H1 and G9A histone methyl transferases, which provides a direct link between histone methylation and this protein at heterochromatic and euchrom... | platelet-type bleeding disorder 17 | Medium | convergence | {"qa_id":"medium_convergence_01974","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EHMT2 and RCOR3 share multiple interacting partners. One such shared partner is described by the following evidence: 'Strikingly, we found that this protein ... | |
medium_convergence_01975 | RBMX and MYC both interact with a shared protein. Evidence indicates that this shared protein is a deubiquitinase that directly binds to MYC, resulting in MYC's deubiquitination and stabilization. Which disease is associated with this shared protein? | Leber congenital amaurosis 19 | Medium | convergence | {"qa_id":"medium_convergence_01975","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RBMX and MYC both interact with a shared protein. Evidence indicates that this shared protein is a deubiquitinase that directly binds to MYC, resulting in MY... | |
medium_convergence_01976 | MEIS1 and KMT2C share multiple protein interaction partners. One such shared partner is Activating signal cointegrator-2 (ASC-2), which functions as a coactivator for transcription factors including the retinoic acid receptor (RAR) and associates with histone H3-K4 methyltransferases MLL3 and MLL4 in mixed-lineage leuk... | Nuclear receptor coactivator 6 | Medium | convergence | {"qa_id":"medium_convergence_01976","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MEIS1 and KMT2C share multiple protein interaction partners. One such shared partner is Activating signal cointegrator-2 (ASC-2), which functions as a coacti... | |
medium_convergence_01977 | CRK and EGFR share multiple interacting partners. One such shared partner is recruited to EGFRvIII and inhibits the transformation of NIH 3T3 cells by EGFRvIII. Which cellular component is this shared partner located in? | plasma membrane | Medium | convergence | {"qa_id":"medium_convergence_01977","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRK and EGFR share multiple interacting partners. One such shared partner is recruited to EGFRvIII and inhibits the transformation of NIH 3T3 cells by EGFRvI... | |
medium_convergence_01978 | VASH1 and MIR424 are both associated with multiple shared biological processes. One shared process is supported by evidence that miR-424 overexpression reduces the proliferation, migration, and cord formation of endothelial cells (ECs) in vitro. Which biological process, connected to this shared entity via the 'negativ... | endothelial cell proliferation | Medium | convergence | {"qa_id":"medium_convergence_01978","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"VASH1 and MIR424 are both associated with multiple shared biological processes. One shared process is supported by evidence that miR-424 overexpression reduc... | |
medium_convergence_01979 | Drotrecogin alfa and Ticlopidine share a common interacting drug. Evidence regarding one of these shared entities states that isobole analysis demonstrated synergism with potentiation in the antithrombotic effects of the combination of this entity and Ticlopidine. Which disease is this specific entity indicated for? | heparin-induced thrombocytopenia | Medium | convergence | {"qa_id":"medium_convergence_01979","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Drotrecogin alfa and Ticlopidine share a common interacting drug. Evidence regarding one of these shared entities states that isobole analysis demonstrated s... | |
medium_convergence_01980 | GNB5 and GNB2 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'The data show that PhLP1 plays a vital role in the assembly of Ggamma2 with all four Gbeta1-4 subunits and in the assembly of Gbeta2 with all twelve Ggamma subunits, without affecting the spe... | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 | Medium | convergence | {"qa_id":"medium_convergence_01980","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNB5 and GNB2 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'The data show that PhLP1 pla... | |
medium_convergence_01981 | Dengue virus and Enterovirus A both upregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold change of 1.549 and an adjusted p-value of 0.01571. Which cellular component is this gene located in? | extracellular space | Medium | convergence | {"qa_id":"medium_convergence_01981","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Enterovirus A both upregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold... | |
medium_convergence_01982 | ESR2 and H3F3A share multiple interacting partners. One such shared partner is supported by evidence stating: 'In addition, [the protein encoded by this shared partner] also bound to PPARgamma, RXRalpha, and ERbeta.' Which protein is encoded by this shared interacting partner? | Deoxynucleotidyltransferase terminal-interacting protein 2 | Medium | convergence | {"qa_id":"medium_convergence_01982","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR2 and H3F3A share multiple interacting partners. One such shared partner is supported by evidence stating: 'In addition, [the protein encoded by this shar... | |
medium_convergence_01983 | BIRC2 and BIRC3 both interact with a shared protein. Evidence regarding this shared entity states: 'The N-terminal (BIR1) and C-terminal (BIR3) BIR domains of cIAP1 were determined to be necessary and sufficient for binding TRAF2 and a specific apoptotic regulator, respectively.' Which disease is associated with this s... | glioblastoma | Medium | convergence | {"qa_id":"medium_convergence_01983","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC2 and BIRC3 both interact with a shared protein. Evidence regarding this shared entity states: 'The N-terminal (BIR1) and C-terminal (BIR3) BIR domains o... | |
medium_convergence_01984 | Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for this gene, derived from a lung fibroblast cell line (study GSE120891), reports a log2 fold change of approximately 3.35 and an adjusted p-value of approximately 0.0... | diabetes mellitus | Medium | convergence | {"qa_id":"medium_convergence_01984","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for t... | |
medium_convergence_01985 | RAD51AP1 and RAD51 both interact with a common protein partner. Experimental evidence confirms a direct in vitro interaction between this shared partner and RAD54B. Which protein is encoded by this shared partner? | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN | Medium | convergence | {"qa_id":"medium_convergence_01985","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAD51AP1 and RAD51 both interact with a common protein partner. Experimental evidence confirms a direct in vitro interaction between this shared partner and ... | |
medium_convergence_01986 | PRKAG3 and PRKAA1 both interact with a specific protein. Evidence indicates that AMPK interacts with this protein and phosphorylates it. Which protein is encoded by the gene corresponding to this entity? | Serine/threonine-protein kinase ULK1 | Medium | convergence | {"qa_id":"medium_convergence_01986","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKAG3 and PRKAA1 both interact with a specific protein. Evidence indicates that AMPK interacts with this protein and phosphorylates it. Which protein is enc... | |
medium_convergence_01987 | ARPC2 and AP2B1 both interact with a shared protein. Evidence for this interaction states: 'The NTA region interacts directly with the Arp2/3 complex based on affinity chromatography, immunoprecipitation assays, and binding assays using purified components.' Which cell type is this shared protein enriched in? | peripheral blood mononuclear cell | Medium | convergence | {"qa_id":"medium_convergence_01987","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARPC2 and AP2B1 both interact with a shared protein. Evidence for this interaction states: 'The NTA region interacts directly with the Arp2/3 complex based o... | |
medium_convergence_01988 | Both Measles morbillivirus and Rift Valley fever phlebovirus are known to upregulate a specific shared gene. Experimental data from a study on pleural mesothelioma cells (GSE117668) indicates that this gene exhibits a log2 fold change of approximately 1.29 and an adjusted p-value of 0.0023. Which protein does this gene... | GCHFR | Medium | convergence | {"qa_id":"medium_convergence_01988","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Rift Valley fever phlebovirus are known to upregulate a specific shared gene. Experimental data from a study on pleural mesoth... | |
medium_convergence_01989 | ATP6V0D2 and LAMTOR2 both interact with a shared protein entity. Evidence regarding this entity states: 'A complex encoded by the MAPKSP1, ROBLD3, and c11orf59 genes, which we term Ragulator, interacts with the Rag GTPases, recruits them to lysosomes, and is essential for mTORC1 activation.' Which protein, connected to... | Ras-related GTP-binding protein A | Medium | convergence | {"qa_id":"medium_convergence_01989","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATP6V0D2 and LAMTOR2 both interact with a shared protein entity. Evidence regarding this entity states: 'A complex encoded by the MAPKSP1, ROBLD3, and c11orf... | |
medium_convergence_01990 | BRCA1 and BRCC3 both interact with a specific shared protein entity. Evidence regarding this entity states: 'We report the identification of receptor-associated protein 80 (a shared interacting protein) as a BRCA1-interacting protein in humans.' Which protein is encoded by this shared entity? | BRCA1-A complex subunit RAP80 | Medium | convergence | {"qa_id":"medium_convergence_01990","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRCA1 and BRCC3 both interact with a specific shared protein entity. Evidence regarding this entity states: 'We report the identification of receptor-associa... | |
medium_convergence_01991 | RYBP and NFIC both interact with a shared protein. Evidence regarding this shared protein states: 'Further biochemical dissection revealed that the six PCGF-RING1A/B combinations form multiple complexes through association with RYBP or its homolog YAF2, which prevents the incorporation of other canonical PRC1 subunits,... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_01991","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RYBP and NFIC both interact with a shared protein. Evidence regarding this shared protein states: 'Further biochemical dissection revealed that the six PCGF-... | |
medium_convergence_01992 | BRD4 and XRCC6 share multiple interaction partners. One such shared partner is part of a telomeric complex that, in addition to TRF2, includes DNA repair proteins Rad50, Mre11, PARP1, and Ku86/Ku70. Which cell type is this shared partner enriched in? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_01992","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD4 and XRCC6 share multiple interaction partners. One such shared partner is part of a telomeric complex that, in addition to TRF2, includes DNA repair pro... | |
medium_convergence_01993 | Vaccinia virus and Human alphaherpesvirus 1 both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of -1.066 and an adjusted p-value of 0.02677. Which cell type is this gene enriched in? | non-classical monocyte | Medium | convergence | {"qa_id":"medium_convergence_01993","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human alphaherpesvirus 1 both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study ... | |
medium_convergence_01994 | DNAAF11 and DNAAF3 are both involved in more than one shared biological process. Evidence concerning one shared entity states: 'Here we show that DNAAF3 (also known as PF22), a previously uncharacterized protein, is essential for the preassembly of dyneins into complexes before their transport into cilia.' Which cellul... | axonemal dynein complex | Medium | convergence | {"qa_id":"medium_convergence_01994","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNAAF11 and DNAAF3 are both involved in more than one shared biological process. Evidence concerning one shared entity states: 'Here we show that DNAAF3 (als... | |
medium_convergence_01998 | PPARA and RBBP4 each interact with more than one shared protein partner. Evidence concerning one shared entity reports that p33(ING1b) associates with Sin3, SAP30, HDAC1, RbAp48, and other proteins to form large protein complexes, whereas p24(ING1c) does not. Which disease is connected to that specific entity through a... | leukemia | Medium | convergence | {"qa_id":"medium_convergence_01998","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PPARA and RBBP4 each interact with more than one shared protein partner. Evidence concerning one shared entity reports that p33(ING1b) associates with Sin3, ... | |
medium_convergence_01999 | ARPC5 and NCK1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Studies in vivo and in vitro demonstrated a highly specific interaction between the SH3 domains of p47nck and Wiskott-Aldrich syndrome protein.' Which protein is encoded by the gene corresponding... | Actin nucleation-promoting factor WAS | Medium | convergence | {"qa_id":"medium_convergence_01999","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARPC5 and NCK1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Studies in vivo and in vitro dem... | |
medium_convergence_02001 | Both Human alphaherpesvirus 3 and Hepacivirus C are reported to downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) shows a log2 fold change of -1.429 and an adjusted p-value of 2.607e-05. In which cellular component is this gene product located? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_02001","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Hepacivirus C are reported to downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study ... | |
medium_convergence_02002 | CHMP4B and CHMP2A both interact with a specific protein. Experimental evidence indicates that in a yeast two-hybrid assay, HD-PTP showed positive interactions with this protein (also known as Shax1), endophilin A1, and ALG-2, but not with RabGAPLP or CIN85. Which disease is associated with this protein through genomic ... | melanoma | Medium | convergence | {"qa_id":"medium_convergence_02002","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHMP4B and CHMP2A both interact with a specific protein. Experimental evidence indicates that in a yeast two-hybrid assay, HD-PTP showed positive interaction... | |
medium_convergence_02003 | Human alphaherpesvirus 1 and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of -1.021 and an adjusted p-value of 0.001107. Which protein is encoded by this gene? | Reduced folate transporter | Medium | convergence | {"qa_id":"medium_convergence_02003","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE11496... | |
medium_convergence_02004 | FANCC and BLM both interact with a shared protein. Evidence regarding this shared protein states: 'The N terminus appears to stabilize the interaction with FANCA and FANCG and is essential for the binding of the FANCC/FANCE subcomplex.' Which gene interacts with this shared protein? | GINS2 | Medium | convergence | {"qa_id":"medium_convergence_02004","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCC and BLM both interact with a shared protein. Evidence regarding this shared protein states: 'The N terminus appears to stabilize the interaction with F... | |
medium_convergence_02005 | MTOR and ATP6V0B share multiple binding partners. One shared partner is described as interacting with a regulatory-associated protein of mTOR and GbetaL to form a complex that serves as the target of rapamycin. Which protein is encoded by the gene corresponding to this shared partner? | Regulatory-associated protein of mTOR | Medium | convergence | {"qa_id":"medium_convergence_02005","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MTOR and ATP6V0B share multiple binding partners. One shared partner is described as interacting with a regulatory-associated protein of mTOR and GbetaL to f... | |
medium_convergence_02006 | POLM and LIG4 each share a binding partner. Evidence concerning one such shared partner states: 'We demonstrate here a direct physical interaction between the XRCC4-ligase IV complex and Ku.' Which protein is encoded by that shared partner? | DNA repair protein Ku80 | Medium | convergence | {"qa_id":"medium_convergence_02006","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"POLM and LIG4 each share a binding partner. Evidence concerning one such shared partner states: 'We demonstrate here a direct physical interaction between th... | |
medium_convergence_02007 | STX6 and BET1 each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'In vitro binding studies established that SNAP-23 binds to syntaxin 6.' Which protein is connected to that entity through the 'encodes' relationship? | Synaptosomal-associated protein 23 | Medium | convergence | {"qa_id":"medium_convergence_02007","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STX6 and BET1 each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'In vitro binding studies established... | |
medium_convergence_02008 | TRIM28 and AR both interact with a shared protein. Evidence regarding this shared entity states: 'We report that TIF1alpha and KAP-1 form homo- and hetero-oligomers in intact mammalian cells.' Which protein is encoded by the gene corresponding to this shared entity? | Transcription intermediary factor 1-alpha | Medium | convergence | {"qa_id":"medium_convergence_02008","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and AR both interact with a shared protein. Evidence regarding this shared entity states: 'We report that TIF1alpha and KAP-1 form homo- and hetero-ol... | |
medium_convergence_02009 | GDF7 and BMP2 both interact with a specific receptor protein. Evidence indicates this receptor is a transmembrane serine/threonine kinase that binds BMP-2 and BMP-7 in association with multiple type I receptors, including BMPR-IA/Brk1, BMPR-IB, and ActR-I. Which disease is causally linked to this receptor? | portal hypertension | Medium | convergence | {"qa_id":"medium_convergence_02009","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GDF7 and BMP2 both interact with a specific receptor protein. Evidence indicates this receptor is a transmembrane serine/threonine kinase that binds BMP-2 an... | |
medium_convergence_02010 | NFIX and TP53 share multiple interacting partners. One such partner is described by evidence stating that its overexpression stabilizes the p53 protein and enhances its transcriptional activity through direct protein-protein interactions. Which disease is associated with this specific interacting partner? | global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies | Medium | convergence | {"qa_id":"medium_convergence_02010","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NFIX and TP53 share multiple interacting partners. One such partner is described by evidence stating that its overexpression stabilizes the p53 protein and e... | |
medium_convergence_02011 | HIST2H3C and CSNK2A1 share multiple interacting partners. One such partner forms a complex with H3.2, and H3.2 purified from this complex is enriched in trimethyl-K27, dimethyl-K4, and acetyl-K9 modifications. Which protein is encoded by the gene corresponding to this interacting partner? | Chromobox protein homolog 2 | Medium | convergence | {"qa_id":"medium_convergence_02011","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HIST2H3C and CSNK2A1 share multiple interacting partners. One such partner forms a complex with H3.2, and H3.2 purified from this complex is enriched in trim... | |
medium_convergence_02012 | RANBP9 and HSP90AA1 share multiple interacting partners. One such partner is supported by evidence stating: 'In this study, we demonstrate that the protein encoded by CDK11B directly interacts with RanBPM in vitro and in human cells.' Which protein is encoded by the gene corresponding to this interacting partner? | Cyclin-dependent kinase 11B | Medium | convergence | {"qa_id":"medium_convergence_02012","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RANBP9 and HSP90AA1 share multiple interacting partners. One such partner is supported by evidence stating: 'In this study, we demonstrate that the protein e... | |
medium_convergence_02013 | GATA3 and LMO2 both interact with a specific transcription factor. Evidence indicates that RBTN1 and RBTN2 interact with leukemogenic bHLH proteins, specifically identifying TAL2 and LYL1 among them. Which protein, connected to this identified entity via an 'encodes' relationship, is the one shared by GATA3 and LMO2? | T-cell acute lymphocytic leukemia protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02013","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GATA3 and LMO2 both interact with a specific transcription factor. Evidence indicates that RBTN1 and RBTN2 interact with leukemogenic bHLH proteins, specific... | |
medium_convergence_02014 | KAT7 and PARP1 both interact with a specific shared protein. Experimental evidence indicates that in cells treated with NSC126188, this shared protein, along with p300 and PARP-1, interacted and bound to the p300 binding site. Which protein is encoded by this shared entity? | Transcription factor Jun | Medium | convergence | {"qa_id":"medium_convergence_02014","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KAT7 and PARP1 both interact with a specific shared protein. Experimental evidence indicates that in cells treated with NSC126188, this shared protein, along... | |
medium_convergence_02015 | Prednisolone and Methylprednisolone both interact with a specific drug. Clinical evidence regarding this drug notes that administration of prednisolone (0.5 mg/kg/day) along with azathioprine failed to suppress disease deterioration. Which disease is this drug indicated for? | colorectal cancer | Medium | convergence | {"qa_id":"medium_convergence_02015","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Prednisolone and Methylprednisolone both interact with a specific drug. Clinical evidence regarding this drug notes that administration of prednisolone (0.5 ... | |
medium_convergence_02017 | HIST2H3A and ATF7IP share multiple binding partners. One such partner is identified by evidence stating: 'Immunoprecipitation and in vitro binding analyses reveal that both MCAF proteins interact with MBD1, this protein, and Sp1 via two evolutionarily conserved distinct domains.' Which disease is associated with this p... | autism spectrum disorder | Medium | convergence | {"qa_id":"medium_convergence_02017","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HIST2H3A and ATF7IP share multiple binding partners. One such partner is identified by evidence stating: 'Immunoprecipitation and in vitro binding analyses r... | |
medium_convergence_02018 | EP300 and SIRT1 both interact with a specific shared protein. Evidence indicates that this shared protein interacts with the transcriptional coactivator p300, resulting in the acetylation of the shared protein on two lysine residues in its N terminus. Which gene encodes this shared protein? | SMAD family member 7 | Medium | convergence | {"qa_id":"medium_convergence_02018","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and SIRT1 both interact with a specific shared protein. Evidence indicates that this shared protein interacts with the transcriptional coactivator p300... | |
medium_convergence_02019 | Rift Valley fever phlebovirus and Zika virus both upregulate a specific gene. Experimental data for this gene in SAEC cells (study GSE102481) reports a log2 fold change of 3.883 and an adjusted p-value of 0.001022. Which disease is associated with this gene as a biomarker? | Squamous cell carcinoma of the head and neck | Medium | convergence | {"qa_id":"medium_convergence_02019","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rift Valley fever phlebovirus and Zika virus both upregulate a specific gene. Experimental data for this gene in SAEC cells (study GSE102481) reports a log2 ... | |
medium_convergence_02020 | FUS and AR both interact with a shared protein. Evidence for one such shared partner states: 'We identified the new AR binding partner [ENTITY] by co-IP (co-immunoprecipitation) in luteinized GCs, and reconfirmed by co-IP, co-localization and GST pull down assay.' Which cell type is this entity enriched in? | non-classical monocyte | Medium | convergence | {"qa_id":"medium_convergence_02020","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FUS and AR both interact with a shared protein. Evidence for one such shared partner states: 'We identified the new AR binding partner [ENTITY] by co-IP (co-... | |
medium_convergence_02021 | MYC and AURKA each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Here, we describe the isolation of a novel 150 kDa protein, designated PARP-10, that interacts with Myc.' Which protein is encoded by that entity? | Protein mono-ADP-ribosyltransferase PARP10 | Medium | convergence | {"qa_id":"medium_convergence_02021","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and AURKA each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Here, we describe the isolation of a nove... | |
medium_convergence_02022 | CDKN1A and TOPBP1 share a common interacting partner. Evidence indicates that MSX2 knockdown suppresses the transcription of this partner, which is identified as NOP2/Sun domain family member 2. This entity regulates the expression of p21 by binding to and causing the 5-methylcytidine methylation of the 3'-untranslated... | intellectual disability, autosomal recessive 5 | Medium | convergence | {"qa_id":"medium_convergence_02022","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDKN1A and TOPBP1 share a common interacting partner. Evidence indicates that MSX2 knockdown suppresses the transcription of this partner, which is identifie... | |
medium_convergence_02023 | DSG4 and DSC1 both interact with multiple shared partners. One such partner is described by the following evidence: 'This mutant transmembrane receptor, which does not bind the common desmosomal plaque proteins plakoglobin and a specific plakophilin isoform, is integrated into functional desmosomes.' Which disease is a... | prostate cancer | Medium | convergence | {"qa_id":"medium_convergence_02023","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DSG4 and DSC1 both interact with multiple shared partners. One such partner is described by the following evidence: 'This mutant transmembrane receptor, whic... | |
medium_convergence_02024 | ERCC4 and CENPS each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We also provide biochemical evidence that MHF1 and MHF2 assemble into a heterodimer that binds DNA and enhances the DNA branch migration activity of FANCM.' Which disease is associated with that entity? | fanconi anemia, complementation group 10 | Medium | convergence | {"qa_id":"medium_convergence_02024","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERCC4 and CENPS each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We also provide biochemical evidence that MH... | |
medium_convergence_02025 | H3F3A and APEX1 share multiple interacting partners. One such shared partner is described as an essential protein involved in the maintenance of genome stability that physically interacts with APE1 and stimulates its enzymatic activities. Which disease is associated with this specific shared partner via a biomarker rel... | idiopathic pulmonary fibrosis | Medium | convergence | {"qa_id":"medium_convergence_02025","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"H3F3A and APEX1 share multiple interacting partners. One such shared partner is described as an essential protein involved in the maintenance of genome stabi... | |
medium_convergence_02028 | The layer of the dentate gyrus and olfactory cortex layer 1 are both classified as a specific type of anatomical structure. Evidence regarding one of these shared classifications states: 'One of the three layers of the dentate gyrus of the hippocampal formation.' Based on this description, which broader anatomical syst... | nervous system | Medium | convergence | {"qa_id":"medium_convergence_02028","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The layer of the dentate gyrus and olfactory cortex layer 1 are both classified as a specific type of anatomical structure. Evidence regarding one of these s... | |
medium_convergence_02029 | Somatotropin and Theophylline share a common interacting drug. Evidence regarding this shared entity states: 'The interaction potential should be considered when drugs with a narrow therapeutic window, such as phenytoin, warfarin, and theophylline, are used concomitantly with proton-pump inhibitors.' Which disease is t... | Zollinger-Ellison syndrome | Medium | convergence | {"qa_id":"medium_convergence_02029","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Somatotropin and Theophylline share a common interacting drug. Evidence regarding this shared entity states: 'The interaction potential should be considered ... | |
medium_convergence_02030 | EP300 and FHL2 share multiple interacting partners. One such partner exhibits enhanced association with p300 and Smad1 upon Erk activation. Which cellular component is this specific partner located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_02030","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and FHL2 share multiple interacting partners. One such partner exhibits enhanced association with p300 and Smad1 upon Erk activation. Which cellular co... | |
medium_convergence_02031 | CREBBP and PPARG both interact with a specific transcription factor. Evidence indicates that the interaction between this transcription factor and CBP is mediated through the p100 protein. Which cellular component is this transcription factor located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_02031","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and PPARG both interact with a specific transcription factor. Evidence indicates that the interaction between this transcription factor and CBP is med... | |
medium_convergence_02032 | CSNK2A2 and PHC2 both interact with a shared protein. Evidence regarding one such shared partner states: 'Here, we have purified a PRC1 isoform comprising subunits [the shared partner], PCGF2, CBX2 and PHC2, two stable subcomplexes ([the shared partner]-PCGF2 and [the shared partner]-PHC2) and the catalytic subunit [th... | Luo-Schoch-Yamamoto syndrome | Medium | convergence | {"qa_id":"medium_convergence_02032","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2A2 and PHC2 both interact with a shared protein. Evidence regarding one such shared partner states: 'Here, we have purified a PRC1 isoform comprising su... | |
medium_convergence_02033 | Both Measles morbillivirus and Influenza A virus have been shown to downregulate a specific shared gene. Experimental evidence for this gene reports a log2 fold change of -1.206 and an adjusted p-value of 0.005065. Which cellular component is this gene located in? | mitochondrion | Medium | convergence | {"qa_id":"medium_convergence_02033","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Influenza A virus have been shown to downregulate a specific shared gene. Experimental evidence for this gene reports a log2 f... | |
medium_convergence_02034 | Both Influenza A virus and Human mastadenovirus C are known to upregulate a specific shared gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line (study GSE106279) reports a log2 fold change of approximately 1.364 and an adjusted p-value of 0.007566. Which cellular component is this ge... | extracellular space | Medium | convergence | {"qa_id":"medium_convergence_02034","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Human mastadenovirus C are known to upregulate a specific shared gene. Experimental data for this gene in a non-small cell lung ad... | |
medium_convergence_02035 | Etanercept and Palifermin both interact with a specific drug. Evidence indicates that this drug, when administered for 24 weeks as adjuvant therapy to interferon and ribavirin, significantly improved virologic response at the end of the treatment period among patients with Hepatitis C Virus (HCV) infection and was asso... | hairy cell leukemia | Medium | convergence | {"qa_id":"medium_convergence_02035","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Etanercept and Palifermin both interact with a specific drug. Evidence indicates that this drug, when administered for 24 weeks as adjuvant therapy to interf... | |
medium_convergence_02036 | RHOA and NRAS both interact with a specific shared gene product. Evidence regarding this entity states: 'In contrast, substrates of this gene product, such as KRas, Rac1, and RhoA, bind to it in both active and inactive forms which requires the presence of poly-basic residues in the C-termini of the GTPases.' Which dis... | Alfadhel syndrome | Medium | convergence | {"qa_id":"medium_convergence_02036","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RHOA and NRAS both interact with a specific shared gene product. Evidence regarding this entity states: 'In contrast, substrates of this gene product, such a... | |
medium_convergence_02037 | RBPJ and PCNA share interaction partners. One such shared partner is described as directly interacting with PCNA, a central component of the replication machinery, and being recruited to sites of DNA replication. Which protein is encoded by this shared partner? | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 | Medium | convergence | {"qa_id":"medium_convergence_02037","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RBPJ and PCNA share interaction partners. One such shared partner is described as directly interacting with PCNA, a central component of the replication mach... | |
medium_convergence_02038 | AKT1 and PRKN both interact with a shared protein kinase. Evidence indicates that in neutrophils, Akt is part of a complex with p38 kinase, a MAPK-activated protein kinase, and Hsp27, where Hsp27 dissociates upon activation. Which cell type is enriched for this shared kinase? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_02038","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKT1 and PRKN both interact with a shared protein kinase. Evidence indicates that in neutrophils, Akt is part of a complex with p38 kinase, a MAPK-activated ... | |
medium_convergence_02039 | CHRNA3 and CHRNA7 each interact with more than one shared protein partner. Evidence concerning one such shared partner reports that P2X2 co-immunoprecipitated the α3β2 nicotinic acetylcholine receptor (nAChR), but not the α4β2 nAChR, in both HEK cells and rat hippocampal membranes, indicating a physical association bet... | Neuronal acetylcholine receptor subunit beta-2 | Medium | convergence | {"qa_id":"medium_convergence_02039","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHRNA3 and CHRNA7 each interact with more than one shared protein partner. Evidence concerning one such shared partner reports that P2X2 co-immunoprecipitate... | |
medium_convergence_02040 | RIGI and CASP10 share multiple binding partners. One such shared partner is identified in the literature as REUL, a RING-finger protein that specifically interacts with RIG-I. Which gene does this shared partner interact with? | CTNNAL1 | Medium | convergence | {"qa_id":"medium_convergence_02040","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RIGI and CASP10 share multiple binding partners. One such shared partner is identified in the literature as REUL, a RING-finger protein that specifically int... | |
medium_convergence_02042 | MCM7 and ORC2 both interact with a common protein partner. Experimental evidence indicates that the C-terminal region of ORC2 interacts directly with the N-terminal region of this shared partner. Which protein is encoded by the gene corresponding to this shared partner? | Origin recognition complex subunit 3 | Medium | convergence | {"qa_id":"medium_convergence_02042","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MCM7 and ORC2 both interact with a common protein partner. Experimental evidence indicates that the C-terminal region of ORC2 interacts directly with the N-t... | |
medium_convergence_02043 | BMP2 and BMP5 both interact with a specific transmembrane serine/threonine kinase. Evidence indicates this kinase binds BMP-2 and BMP-7 in association with multiple type I receptors, including BMPR-IA/Brk1, BMPR-IB, and ActR-I. Which protein is encoded by the gene corresponding to this kinase? | Bone morphogenetic protein receptor type-2 | Medium | convergence | {"qa_id":"medium_convergence_02043","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMP2 and BMP5 both interact with a specific transmembrane serine/threonine kinase. Evidence indicates this kinase binds BMP-2 and BMP-7 in association with m... | |
medium_convergence_02044 | EGR2 and TEAD4 both interact with a specific transcriptional coactivator. Evidence indicates that the interaction between IRF2BP2 and VGLL4 enhances the binding of TEAD4 to this coactivator, leading to the transcriptional coactivation of CTGF. Which protein encodes this coactivator? | Transcriptional coactivator YAP1 | Medium | convergence | {"qa_id":"medium_convergence_02044","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGR2 and TEAD4 both interact with a specific transcriptional coactivator. Evidence indicates that the interaction between IRF2BP2 and VGLL4 enhances the bind... | |
medium_convergence_02046 | Enterovirus A and Cardiovirus A both upregulate a specific gene. Evidence for this gene in rhabdomyosarcoma cells (from study GSE103308) reports a log2 fold change of approximately 3.58 and an adjusted p-value of 0.0031. Which cell type is this gene enriched in? | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | convergence | {"qa_id":"medium_convergence_02046","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Enterovirus A and Cardiovirus A both upregulate a specific gene. Evidence for this gene in rhabdomyosarcoma cells (from study GSE103308) reports a log2 fold ... | |
medium_convergence_02047 | CDK8 and H3C1 each interact with more than one shared protein. Evidence concerning one of these shared entities states that the entity (also known as 13L) physically links the CDK8 module to the Mediator complex. Which protein is encoded by this shared entity? | Mediator of RNA polymerase II transcription subunit 13 | Medium | convergence | {"qa_id":"medium_convergence_02047","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK8 and H3C1 each interact with more than one shared protein. Evidence concerning one of these shared entities states that the entity (also known as 13L) ph... | |
medium_convergence_02048 | HTT and USP7 share common interaction partners. One such shared partner is described by evidence stating: 'The ability of this protein to directly interact with and recruit USP7 to chromocenters implicates it as an additional factor that can potentially regulate Dnmt1 activity during cell proliferation.' Which protein ... | Methyl-CpG-binding domain protein 4 | Medium | convergence | {"qa_id":"medium_convergence_02048","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HTT and USP7 share common interaction partners. One such shared partner is described by evidence stating: 'The ability of this protein to directly interact w... | |
medium_convergence_02049 | KHDRBS1 and MAPT both interact with a shared protein. Evidence regarding this shared protein states: 'We have recently found that Sam68 is a substrate of the insulin receptor (IR) and that Tyr-phosphorylated Sam68 associates with the SH2 domains of the regulatory subunit of PI3K.' Which protein is encoded by the gene c... | Phosphatidylinositol 3-kinase regulatory subunit alpha | Medium | convergence | {"qa_id":"medium_convergence_02049","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KHDRBS1 and MAPT both interact with a shared protein. Evidence regarding this shared protein states: 'We have recently found that Sam68 is a substrate of the... | |
medium_convergence_02050 | FANCA and FANCD2 each interact with more than one shared protein. Evidence concerning one such shared entity reports that its protein product is a component of a nuclear protein complex containing FANCA and FANCC. Which protein is encoded by the gene corresponding to that entity? | Fanconi anemia group G protein | Medium | convergence | {"qa_id":"medium_convergence_02050","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCA and FANCD2 each interact with more than one shared protein. Evidence concerning one such shared entity reports that its protein product is a component ... | |
medium_convergence_02051 | C2orf47 (also known as MAIP1) and MCU are both involved in more than one shared biological process. Evidence concerning one of these shared processes states: 'Two recently identified proteins, the mitochondrial Ca(2+) uniporter (MCU), which is the pore-forming subunit of a Ca(2+) channel, and mitochondrial calcium upta... | intracellular calcium ion homeostasis | Medium | convergence | {"qa_id":"medium_convergence_02051","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"C2orf47 (also known as MAIP1) and MCU are both involved in more than one shared biological process. Evidence concerning one of these shared processes states:... | |
medium_convergence_02052 | GNAT3 and ARRB1 both physically interact with a specific gene product. Experimental evidence indicates that beta-arrestin 1 physically interacts with the delta opioid receptor (DOR) in an agonist-enhanced manner, and that truncation of the carboxyl terminus of DOR partially impairs this interaction. Which protein is en... | Delta-type opioid receptor | Medium | convergence | {"qa_id":"medium_convergence_02052","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNAT3 and ARRB1 both physically interact with a specific gene product. Experimental evidence indicates that beta-arrestin 1 physically interacts with the del... | |
medium_convergence_02054 | Asparaginase (Escherichia coli) and Folic acid each interact with more than one shared drug. Evidence concerning one shared entity reports that growth inhibition by sulfa drugs was reduced by the addition of folic acid, indicating that they inhibit folate synthesis in green algae. Which disease is connected to that ent... | rheumatic fever | Medium | convergence | {"qa_id":"medium_convergence_02054","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Asparaginase (Escherichia coli) and Folic acid each interact with more than one shared drug. Evidence concerning one shared entity reports that growth inhibi... | |
medium_convergence_02055 | ANAPC7 and BUB1B both interact with a shared protein complex component. Evidence regarding this shared component notes that it binds APC16 and APC7, and contains a >200-residue loop that is heavily phosphorylated during mitosis, although the basis for its interactions and whether loop phosphorylation is required for ub... | CDH1 | Medium | convergence | {"qa_id":"medium_convergence_02055","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC7 and BUB1B both interact with a shared protein complex component. Evidence regarding this shared component notes that it binds APC16 and APC7, and cont... | |
medium_convergence_02056 | Both Human alphaherpesvirus 1 and Human alphaherpesvirus 3 upregulate a specific host gene. In a study of monocytic leukemia cell lines (GSE114966), this gene exhibited a log2 fold change of approximately 4.10 and an adjusted p-value of 0.0045. What molecular function is enabled by this gene? | DNA-binding transcription factor activity | Medium | convergence | {"qa_id":"medium_convergence_02056","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Human alphaherpesvirus 3 upregulate a specific host gene. In a study of monocytic leukemia cell lines (GSE114966), this gen... | |
medium_convergence_02057 | CTBP2 and JUN share multiple interacting partners. One such partner is described in evidence stating: 'Here, we demonstrate interaction between c-Jun and c-Fos with Cbfa/Runt proteins.' Which cell type is this specific partner enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_02057","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTBP2 and JUN share multiple interacting partners. One such partner is described in evidence stating: 'Here, we demonstrate interaction between c-Jun and c-F... | |
medium_convergence_02058 | HSPA8 and HSP90AA1 both interact with a shared protein. Evidence regarding this shared protein states: 'Analyses of the cotransporter immunoprecipitates revealed that it formed complexes with the core chaperones Hsp90, Hsp70, and Hsp40.' Which protein is encoded by this shared gene? | Solute carrier family 12 member 3 | Medium | convergence | {"qa_id":"medium_convergence_02058","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA8 and HSP90AA1 both interact with a shared protein. Evidence regarding this shared protein states: 'Analyses of the cotransporter immunoprecipitates reve... | |
medium_convergence_02059 | ARPC3 and ACTB each share a binding partner with another gene. Evidence concerning one such shared partner states: 'We have used deletion analysis to show that both the shared partner and Scar1 interact with the p21 subunit of the Arp2/3 complex through their carboxyl termini.' Which protein is encoded by that shared p... | Actin nucleation-promoting factor WAS | Medium | convergence | {"qa_id":"medium_convergence_02059","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARPC3 and ACTB each share a binding partner with another gene. Evidence concerning one such shared partner states: 'We have used deletion analysis to show th... | |
medium_convergence_02060 | CBX1 and NFIX share multiple interacting partners. One such shared partner is a protein that silences the activation potential of BRCA2 exon 3, associates with chromatin regulators HP1beta and BS69, and localizes to sites of repair following DNA damage. Which protein is encoded by this shared partner? | BRCA2-interacting transcriptional repressor EMSY | Medium | convergence | {"qa_id":"medium_convergence_02060","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX1 and NFIX share multiple interacting partners. One such shared partner is a protein that silences the activation potential of BRCA2 exon 3, associates wi... | |
medium_convergence_02061 | RIPK1 and CD14 each interact with more than one shared protein. Evidence concerning one of these shared proteins states that a specific adapter molecule recruited the kinases receptor interacting protein (RIP)-1 and RIP3 through its RIP homotypic interaction motif. Which protein is encoded by that shared entity? | TIR domain-containing adapter molecule 1 | Medium | convergence | {"qa_id":"medium_convergence_02061","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RIPK1 and CD14 each interact with more than one shared protein. Evidence concerning one of these shared proteins states that a specific adapter molecule recr... | |
medium_convergence_02062 | RFC3 and CLSPN each interact with more than one shared protein. Evidence concerning one shared entity reports that TRIM21-mediated K63-linked ubiquitination of CLASPIN counteracts the K6-linked ubiquitination of CLASPIN, which is essential for its interaction with this shared protein and subsequent chromatin loading. W... | TIMELESS-interacting protein | Medium | convergence | {"qa_id":"medium_convergence_02062","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RFC3 and CLSPN each interact with more than one shared protein. Evidence concerning one shared entity reports that TRIM21-mediated K63-linked ubiquitination ... | |
medium_convergence_02063 | DNM1 and ABL2 each interact with more than one shared protein. Evidence concerning one shared entity reports that Dynamin and a shared adapter protein co-precipitated when cell lysates were immunoprecipitated with an anti-adapter protein antibody. Which protein is connected to that entity through the 'encodes' relation... | SH2/SH3 adapter protein NCK1 | Medium | convergence | {"qa_id":"medium_convergence_02063","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNM1 and ABL2 each interact with more than one shared protein. Evidence concerning one shared entity reports that Dynamin and a shared adapter protein co-pre... | |
medium_convergence_02064 | STUB1 and EP300 both interact with a specific shared protein. Evidence indicates that CHIP binds directly to an intrinsically disordered domain in the central region of this protein (residues 106-140), and this site is sufficient to form a stable complex with CHIP in cells and to compete in trans with the full-length p... | Interferon regulatory factor 1 | Medium | convergence | {"qa_id":"medium_convergence_02064","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and EP300 both interact with a specific shared protein. Evidence indicates that CHIP binds directly to an intrinsically disordered domain in the centra... | |
medium_convergence_02065 | PPFIA2 and PPFIA3 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The C-terminal, non-coiled coil regions of alpha-liprins bind to the membrane-distal phosphatase domains of a specific family of receptor-type tyrosine-protein phosphatases, as well as to the ... | Receptor-type tyrosine-protein phosphatase F | Medium | convergence | {"qa_id":"medium_convergence_02065","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PPFIA2 and PPFIA3 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The C-terminal, non-coiled co... | |
medium_convergence_02066 | CRK and PDGFD both interact with a specific receptor protein. Experimental evidence indicates that a GST fusion protein of full-length CrkII binds to the activated PDGF beta-receptor. Which protein is encoded by this receptor gene? | Platelet-derived growth factor receptor beta | Medium | convergence | {"qa_id":"medium_convergence_02066","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRK and PDGFD both interact with a specific receptor protein. Experimental evidence indicates that a GST fusion protein of full-length CrkII binds to the act... | |
medium_convergence_02067 | EPB41L2 and PRKN share common interacting partners. One such shared partner functions as a scaffold where circEPB41L2 binds to its RRM1 domain and the E3 ubiquitin ligase TRIP12, thereby promoting TRIP12-mediated polyubiquitylation and degradation of this partner. Which protein is encoded by the gene corresponding to t... | Polypyrimidine tract-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02067","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EPB41L2 and PRKN share common interacting partners. One such shared partner functions as a scaffold where circEPB41L2 binds to its RRM1 domain and the E3 ubi... | |
medium_convergence_02068 | DLG3 and DLG4 both interact with a specific protein entity. Evidence regarding this entity states: 'We have isolated here a novel protein family consisting of at least four members which specifically interact with PSD-95/SAP90 and its related proteins through the guanylate kinase domain, and named these proteins SAPAPs... | Disks large-associated protein 2 | Medium | convergence | {"qa_id":"medium_convergence_02068","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLG3 and DLG4 both interact with a specific protein entity. Evidence regarding this entity states: 'We have isolated here a novel protein family consisting o... | |
medium_convergence_02069 | BAIAP2 and MAP3K2 share common interacting partners. One such shared partner is characterized by evidence showing that it modulates the degradation of mitogen-activated protein kinase kinase kinase 2 (MEKK2) by constitutively and directly binding to MEKK2, thereby promoting its poly-ubiquitination. Which protein is enc... | E3 ubiquitin-protein ligase NEDD4-like | Medium | convergence | {"qa_id":"medium_convergence_02069","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BAIAP2 and MAP3K2 share common interacting partners. One such shared partner is characterized by evidence showing that it modulates the degradation of mitoge... | |
medium_convergence_02070 | MICU1 and MCUR1 are both involved in more than one shared biological process. Evidence concerning one of these shared processes indicates that perturbing interactions involving MCU elicits unregulated, constitutive Ca2+ flux into mitochondria. Which biological process is connected to that entity through an 'is a' relat... | mitochondrial calcium ion transmembrane transport | Medium | convergence | {"qa_id":"medium_convergence_02070","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MICU1 and MCUR1 are both involved in more than one shared biological process. Evidence concerning one of these shared processes indicates that perturbing int... | |
medium_convergence_02071 | SERP1 and BAG6 both interact with a shared protein partner. Evidence regarding this partner states: 'Thereby, Hsp70 and Bag-6/Bat-3/Scythe were identified as novel interaction partners while interaction with Hsc70 was confirmed.' Which disease is associated with this shared protein partner? | alcohol abuse | Medium | convergence | {"qa_id":"medium_convergence_02071","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SERP1 and BAG6 both interact with a shared protein partner. Evidence regarding this partner states: 'Thereby, Hsp70 and Bag-6/Bat-3/Scythe were identified as... | |
medium_convergence_02072 | Human alphaherpesvirus 1 and Hepacivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of -1.455 and an adjusted p-value of 0.002513. Which disease is associated with this gene as a biomarker? | tetralogy of fallot | Medium | convergence | {"qa_id":"medium_convergence_02072","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Hepacivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114... | |
medium_convergence_02073 | Rhinovirus A and Cardiovirus A both downregulate a specific gene. Evidence for this gene shows a log2 fold change of -2.642 and an adjusted p-value of 0.02834. Which protein does this gene product interact with? | VCP | Medium | convergence | {"qa_id":"medium_convergence_02073","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Cardiovirus A both downregulate a specific gene. Evidence for this gene shows a log2 fold change of -2.642 and an adjusted p-value of 0.0283... | |
medium_convergence_02074 | FANCA and DCLRE1A each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'We have previously demonstrated that the FANCA and this protein interact and form a nuclear complex in normal cells, suggesting that the proteins cooperate in a nuclear function.' Which protei... | Fanconi anemia group C protein | Medium | convergence | {"qa_id":"medium_convergence_02074","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCA and DCLRE1A each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'We have previously demonstrat... | |
medium_convergence_02075 | CSNK2A1 and AKT1 both interact with a specific shared protein. Experimental evidence indicates that CK2 is recruited to this protein following ionizing radiation and phosphorylates conserved residues Ser 154, 649, 651, and 683 within its N- and C-terminal domains in mouse models. Which protein is encoded by the gene co... | NAD-dependent protein deacetylase sirtuin-1 | Medium | convergence | {"qa_id":"medium_convergence_02075","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2A1 and AKT1 both interact with a specific shared protein. Experimental evidence indicates that CK2 is recruited to this protein following ionizing radia... | |
medium_convergence_02076 | ESR1 and SMAD2 share a common interacting partner. Evidence indicates that estrogen induces an interaction between this shared partner and ERalpha. Which cell type is this shared partner enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_02076","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and SMAD2 share a common interacting partner. Evidence indicates that estrogen induces an interaction between this shared partner and ERalpha. Which cel... | |
medium_convergence_02078 | EGFR and FBXW7 share multiple interacting partners. One such shared partner is characterized by evidence stating that GSK3β-mediated phosphorylation of this entity facilitates its interaction with FBXW7, specifically involving the DNA binding domain of the entity and domains 1, 2, 6, and 7 of the FBXW7 WD40 repeat regi... | MED14 | Medium | convergence | {"qa_id":"medium_convergence_02078","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and FBXW7 share multiple interacting partners. One such shared partner is characterized by evidence stating that GSK3β-mediated phosphorylation of this ... | |
medium_convergence_02079 | EXOSC6 and DIS3 both interact with a shared protein partner. Evidence regarding this partner states: 'Here, we demonstrate the association of two different Dis3p homologs--hDIS3 and hDIS3L--with the human exosome core.' Which protein is encoded by this shared partner? | Exosome complex component RRP45 | Medium | convergence | {"qa_id":"medium_convergence_02079","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EXOSC6 and DIS3 both interact with a shared protein partner. Evidence regarding this partner states: 'Here, we demonstrate the association of two different D... | |
medium_convergence_02080 | TRIM28 and CBX3 both interact with a shared protein. Evidence indicates that this shared protein associates with transcriptional repressors including KAP1, histone deacetylases HDAC1/2, and the histone methyltransferase G9a/GLP, and it modulates the interaction of HDAC1 and KAP1 with heterochromatin. Which cell type is... | basophil | Medium | convergence | {"qa_id":"medium_convergence_02080","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and CBX3 both interact with a shared protein. Evidence indicates that this shared protein associates with transcriptional repressors including KAP1, h... | |
medium_convergence_02081 | Pantoprazole and Omeprazole both interact with a specific drug. Evidence regarding this drug indicates that its plasma concentration increases when coadministered with Omeprazole in healthy subjects, a phenomenon likely secondary to increased bioavailability attributable to increased gastric pH. Which disease is this d... | HIV infectious disease | Medium | convergence | {"qa_id":"medium_convergence_02081","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Pantoprazole and Omeprazole both interact with a specific drug. Evidence regarding this drug indicates that its plasma concentration increases when coadminis... | |
medium_convergence_02082 | DNMT3B and NCOR1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that it binds the N-CoR corepressor and is required for N-CoR-mediated repression by antagonist-bound estrogen receptor and the homeodomain protein Rpx, as well as N-CoR suppression of tr... | Histone deacetylase complex subunit SAP30 | Medium | convergence | {"qa_id":"medium_convergence_02082","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNMT3B and NCOR1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that it binds the N-CoR ... | |
medium_convergence_02083 | EIF2B3 and EIF2B5 are both involved in multiple shared biological processes. One such shared process is linked to the entity 'Eukaryotic translation initiation factor (eIF) 2B', which is described as the guanine nucleotide exchange factor for eIF2 and a key target of translation control at the initiation step. Which bi... | translational initiation | Medium | convergence | {"qa_id":"medium_convergence_02083","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF2B3 and EIF2B5 are both involved in multiple shared biological processes. One such shared process is linked to the entity 'Eukaryotic translation initiati... |
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