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medium_convergence_01866 | GRIK5 and GRIN1 both physically interact with a common partner protein. Experimental evidence indicates that immunoprecipitation using an anti-NR1 antibody reveals that the majority of NR3A associates with NR1 in the postnatal day 10 rat cortex (80 +/- 8%), a level that decreases by half (38 +/- 4%) in the adult rat co... | PTPA | Medium | convergence | {"qa_id":"medium_convergence_01866","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRIK5 and GRIN1 both physically interact with a common partner protein. Experimental evidence indicates that immunoprecipitation using an anti-NR1 antibody r... | |
medium_convergence_01867 | MAP4K1 and PPP2R1A both interact with a shared protein. Evidence regarding one such shared partner states: 'We found that the shared partner interacted with HPK1 and that the proline-rich region of HPK1 was necessary and sufficient for this interaction.' Which cell type is enriched for this specific shared partner? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_01867","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAP4K1 and PPP2R1A both interact with a shared protein. Evidence regarding one such shared partner states: 'We found that the shared partner interacted with ... | |
medium_convergence_01868 | TNK2 and KHDRBS1 share common interaction partners. One such shared partner is a Src family kinase that interacts most strongly with ACK1 via ACK1's C-terminal proline-rich domain binding to the kinase's SH3 domains. Which disease is associated with this specific kinase? | autoinflammation with pulmonary and cutaneous vasculitis | Medium | convergence | {"qa_id":"medium_convergence_01868","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TNK2 and KHDRBS1 share common interaction partners. One such shared partner is a Src family kinase that interacts most strongly with ACK1 via ACK1's C-termin... | |
medium_convergence_01869 | TRAF1 and TRAF6 both interact with a specific protein. Evidence indicates that this protein interacts with tumor necrosis factor receptor-associated factors (TRAFs) 1, 2, 3, 5, and 6 both in vitro and in cells. Which disease is connected to this shared interacting partner through genomic alterations? | periapical periodontitis | Medium | convergence | {"qa_id":"medium_convergence_01869","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRAF1 and TRAF6 both interact with a specific protein. Evidence indicates that this protein interacts with tumor necrosis factor receptor-associated factors ... | |
medium_convergence_01870 | ANAPC10 and BUB1B both interact with a shared protein that is a core component of the mitotic checkpoint complex (MCC), which consists of hBUBR1, this protein, CDC20, and MAD2 in near equal stoichiometry. Which disease is associated with this shared protein? | aneuploidy | Medium | convergence | {"qa_id":"medium_convergence_01870","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC10 and BUB1B both interact with a shared protein that is a core component of the mitotic checkpoint complex (MCC), which consists of hBUBR1, this protei... | |
medium_convergence_01871 | Clemastine and Morphine share interactions with multiple drugs. One such shared drug is characterized by evidence stating that although chronic treatment with it significantly enhanced morphine-induced hyperlocomotion, this enhancement was suppressed by co-treatment with the mGlu5 receptor antagonist MPEP. Which diseas... | insomnia | Medium | convergence | {"qa_id":"medium_convergence_01871","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Clemastine and Morphine share interactions with multiple drugs. One such shared drug is characterized by evidence stating that although chronic treatment wit... | |
medium_convergence_01872 | GRIN2B and ACTN2 both interact with a specific protein. Evidence indicates that the NR2B subunit of the NMDAR, but not the NR2A or NR1 subunits, interacts in vivo and in vitro with this protein, which is described as a Ca(2+)/calmodulin-dependent Ras-guanine-nucleotide-releasing factor. What molecular function is enabl... | guanyl-nucleotide exchange factor activity | Medium | convergence | {"qa_id":"medium_convergence_01872","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRIN2B and ACTN2 both interact with a specific protein. Evidence indicates that the NR2B subunit of the NMDAR, but not the NR2A or NR1 subunits, interacts in... | |
medium_convergence_01873 | Human gammaherpesvirus 4 and Human immunodeficiency virus 1 both downregulate a specific gene. Evidence for this gene in a particular study reports a log2 fold change of -2.542 and an adjusted p-value of 0.02411. Which cell type is this gene enriched in? | regulatory T cell | Medium | convergence | {"qa_id":"medium_convergence_01873","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human gammaherpesvirus 4 and Human immunodeficiency virus 1 both downregulate a specific gene. Evidence for this gene in a particular study reports a log2 fo... | |
medium_convergence_01874 | GTF3A and GTF3C1 each interact with more than one shared protein partner. Evidence concerning one such shared partner indicates that the protein hTFIIIC90 interacts with the hTFIIIC220, hTFIIIC110, and hTFIIIC63 subunits of TFIIIC, the hTFIIIB90 subunit of TFIIIB, and the human RPC39 (hRPC39) and hRPC62 subunits of an ... | General transcription factor 3C polypeptide 4 | Medium | convergence | {"qa_id":"medium_convergence_01874","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GTF3A and GTF3C1 each interact with more than one shared protein partner. Evidence concerning one such shared partner indicates that the protein hTFIIIC90 in... | |
medium_convergence_01876 | ESR1 and HSP90AA1 share multiple interacting partners. One such partner is described as adopting an altered conformation and utilizing its exposed VLWKLLKVV peptide domain (codons 98 to 106) to bind the estrogen receptor (ER). Which protein is encoded by this specific interacting partner? | Methylated-DNA--protein-cysteine methyltransferase | Medium | convergence | {"qa_id":"medium_convergence_01876","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and HSP90AA1 share multiple interacting partners. One such partner is described as adopting an altered conformation and utilizing its exposed VLWKLLKVV ... | |
medium_convergence_01877 | HSP90AA1 and PRKN each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Further studies indicated that a receptor-interacting serine/threonine-protein kinase formed a complex with Triad3A and heat shock protein 90 (Hsp90), which is a chaperone protein capable of maintaini... | Receptor-interacting serine/threonine-protein kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_01877","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSP90AA1 and PRKN each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Further studies indicated that a rece... | |
medium_convergence_01878 | Both TG and NCOR1 share a binding partner. Evidence regarding one such shared entity states: 'In contrast, in the absence of T3, the L454S mutant interacts much more strongly with nuclear receptor corepressor (NCoR) than does the wild-type receptor, and the T3-dependent release of NCoR is markedly impaired.' Which prot... | Thyroid hormone receptor alpha | Medium | convergence | {"qa_id":"medium_convergence_01878","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both TG and NCOR1 share a binding partner. Evidence regarding one such shared entity states: 'In contrast, in the absence of T3, the L454S mutant interacts m... | |
medium_convergence_01879 | LATS2 and LATS1 each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Here, we show that a specific scaffold protein associates with and activates Lats (large tumor suppressor) 1 and 2 kinases by stimulating their phosphorylation on the hydrophobic motif.' Which di... | secondary neoplasm | Medium | convergence | {"qa_id":"medium_convergence_01879","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LATS2 and LATS1 each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Here, we show that a specific sc... | |
medium_convergence_01880 | TOPBP1 and LRRK2 share common interacting partners. One such shared partner is a protein that localizes to the ER membrane and interacts with sarco/endoplasmic reticulum Ca2+ ATPases. Which gene encodes this specific shared interacting protein? | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | Medium | convergence | {"qa_id":"medium_convergence_01880","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TOPBP1 and LRRK2 share common interacting partners. One such shared partner is a protein that localizes to the ER membrane and interacts with sarco/endoplasm... | |
medium_convergence_01881 | Human alphaherpesvirus 1 and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 1.187 and an adjusted p-value of 0.002873. Which protein is encoded by this gene? | GTP-binding protein RAD | Medium | convergence | {"qa_id":"medium_convergence_01881","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE11496... | |
medium_convergence_01882 | Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. In a study of cervical adenocarcinoma cell lines (GSE11238), this gene exhibited a log2 fold change of approximately -1.092 and an adjusted p-value of 0.0001019. Which protein interacts with this gene product? | SLC39A4 | Medium | convergence | {"qa_id":"medium_convergence_01882","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. In a study of cervical adenocarcinoma cell lines (GSE11238), this gene exhibite... | |
medium_convergence_01883 | ARAF and LAMTOR3 both interact with a common protein partner. Experimental evidence indicates that this partner was identified as a novel interactor of a MAP kinase kinase in yeast two-hybrid screening, alongside c-Raf and KSR. Which cell type is this shared partner enriched in? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_01883","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARAF and LAMTOR3 both interact with a common protein partner. Experimental evidence indicates that this partner was identified as a novel interactor of a MAP... | |
medium_convergence_01884 | FBXW11 and APC both interact with a shared protein. Experimental evidence indicates that this shared protein was co-precipitated with either GSK3beta or beta-catenin in both cell lines using immunoprecipitation. Which protein is encoded by this shared entity? | Glycogen synthase kinase-3 beta | Medium | convergence | {"qa_id":"medium_convergence_01884","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FBXW11 and APC both interact with a shared protein. Experimental evidence indicates that this shared protein was co-precipitated with either GSK3beta or beta... | |
medium_convergence_01885 | CHD3 and CBX5 both interact with a shared protein. Evidence indicates that depletion or inactivation of this shared protein, or ablation of its interaction with a KRAB-associated protein (SUMO1), bypasses the phosphorylated form of that KRAB-associated protein's role in repair. Which protein is encoded by the gene corr... | Transcription intermediary factor 1-beta | Medium | convergence | {"qa_id":"medium_convergence_01885","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD3 and CBX5 both interact with a shared protein. Evidence indicates that depletion or inactivation of this shared protein, or ablation of its interaction w... | |
medium_convergence_01886 | CDC37 and ESR1 share multiple interacting partners. One specific shared partner is characterized by direct interaction with the ligand binding domain of ER and recruitment to the proximal promoter regions of ER target genes upon gene induction. Which disease is associated with this specific entity through genomic alter... | colorectal carcinoma | Medium | convergence | {"qa_id":"medium_convergence_01886","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC37 and ESR1 share multiple interacting partners. One specific shared partner is characterized by direct interaction with the ligand binding domain of ER a... | |
medium_convergence_01887 | FANCD2 and FANCE both interact with a specific protein complex component. Evidence indicates that cells lacking this component, or expressing a version of it deficient in the UBZ domain, are selectively sensitive to interstrand crosslink (ICL)-inducing agents. Furthermore, the UBZ domain is required for this component'... | Structure-specific endonuclease subunit SLX4 | Medium | convergence | {"qa_id":"medium_convergence_01887","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCD2 and FANCE both interact with a specific protein complex component. Evidence indicates that cells lacking this component, or expressing a version of it... | |
medium_convergence_01889 | BIRC2 and CASP10 each interact with more than one shared protein. Evidence concerning one of these shared proteins indicates that EGLN3 competes with cIAP1 for binding to IKKγ, thereby inhibiting the cIAP1-IKKγ interaction, IKKγ ubiquitination, and IKK-NF-κB signaling. Which protein is encoded by the gene corresponding... | NF-kappa-B essential modulator | Medium | convergence | {"qa_id":"medium_convergence_01889","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC2 and CASP10 each interact with more than one shared protein. Evidence concerning one of these shared proteins indicates that EGLN3 competes with cIAP1 f... | |
medium_convergence_01890 | KDM1A and RCOR1 share a common interacting partner. Evidence for one such partner states: 'We purified a complex of nuclear [entity]-binding proteins by affinity chromatography and identified its components by mass spectrometry as Jarid1b/Plu-1, G9a, LSD1, CoREST and CtBP1.' Which disease is associated with this specif... | adenoma | Medium | convergence | {"qa_id":"medium_convergence_01890","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KDM1A and RCOR1 share a common interacting partner. Evidence for one such partner states: 'We purified a complex of nuclear [entity]-binding proteins by affi... | |
medium_convergence_01891 | DDB1 and KPNA1 share a common interacting partner. Experimental evidence indicates that the multi-subunit cullin RING E3 ligase complex, comprising VprBP, this shared partner, Cul4A, and Roc1, associates with full-length versions of this partner through VprBP. Which protein is encoded by this shared partner? | V(D)J recombination-activating protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01891","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DDB1 and KPNA1 share a common interacting partner. Experimental evidence indicates that the multi-subunit cullin RING E3 ligase complex, comprising VprBP, th... | |
medium_convergence_01892 | Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for this gene, derived from a lung fibroblast cell line (study GSE120891), reports a log2 fold change of approximately 1.195 and an adjusted p-value of 0.04322. Which d... | small cell lung carcinoma | Medium | convergence | {"qa_id":"medium_convergence_01892","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for t... | |
medium_convergence_01893 | Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental data from a study on lung fibroblast cell lines (GSE120891) indicates that this gene exhibits a log2 fold change of approximately 3.265 and an adjusted p-value of 0... | Galactosylceramide sulfotransferase | Medium | convergence | {"qa_id":"medium_convergence_01893","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental d... | |
medium_convergence_01894 | ATF2 and ACTB both interact with a shared protein. Evidence indicates that a yeast two-hybrid screen identified a component of the INO80 chromatin-remodeling complex as a novel interacting partner for this shared protein. Which protein product is encoded by this shared gene? | RuvB-like 2 | Medium | convergence | {"qa_id":"medium_convergence_01894","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATF2 and ACTB both interact with a shared protein. Evidence indicates that a yeast two-hybrid screen identified a component of the INO80 chromatin-remodeling... | |
medium_convergence_01895 | EGFR and PRKN share multiple interacting partners. One such shared partner is described in an experiment where epitope-tagged sorting nexins SNX1, SNX1A, this protein, and SNX4 coimmunoprecipitated with receptor tyrosine kinases for EGF, platelet-derived growth factor, and insulin when expressed in COS7 cells. Which pr... | Sorting nexin-2 | Medium | convergence | {"qa_id":"medium_convergence_01895","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and PRKN share multiple interacting partners. One such shared partner is described in an experiment where epitope-tagged sorting nexins SNX1, SNX1A, thi... | |
medium_convergence_01896 | AKAP10 and PRKACG share multiple protein interaction partners. One such shared partner is characterized by evidence stating: 'Based on coprecipitation assays, the R binding domain interacts with the N-terminal dimerization domain of RIalpha and RIIalpha.' Which protein product is encoded by the gene corresponding to th... | cAMP-dependent protein kinase type I-alpha regulatory subunit | Medium | convergence | {"qa_id":"medium_convergence_01896","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKAP10 and PRKACG share multiple protein interaction partners. One such shared partner is characterized by evidence stating: 'Based on coprecipitation assays... | |
medium_convergence_01897 | Both Human gammaherpesvirus 4 and Severe acute respiratory syndrome-related coronavirus are known to downregulate a specific gene. Experimental data from a study on gamma delta T-lymphocytes (GSE13906) indicates that for one such shared target, the log2 fold change is -2.398 and the adjusted p-value is 0.04148. Which d... | sarcoma | Medium | convergence | {"qa_id":"medium_convergence_01897","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human gammaherpesvirus 4 and Severe acute respiratory syndrome-related coronavirus are known to downregulate a specific gene. Experimental data from a s... | |
medium_convergence_01898 | EP300 and KAT2A both interact with a specific shared protein partner. Evidence indicates that the p300 histone acetyltransferase directly acetylates this partner in vitro at three specific residues. Which disease is associated with this protein partner through genomic alterations? | pheochromocytoma | Medium | convergence | {"qa_id":"medium_convergence_01898","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and KAT2A both interact with a specific shared protein partner. Evidence indicates that the p300 histone acetyltransferase directly acetylates this par... | |
medium_convergence_01899 | HLA-A and B2M both interact with a specific protein complex component. Evidence indicates that the T134K variant's inefficiency in presenting intracellular antigen is linked to its failure to interact with the TAP heterodimer. Which disease is associated with this specific component through genomic alterations? | psoriasis | Medium | convergence | {"qa_id":"medium_convergence_01899","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HLA-A and B2M both interact with a specific protein complex component. Evidence indicates that the T134K variant's inefficiency in presenting intracellular a... | |
medium_convergence_01900 | CRKL and PTK2 each interact with more than one shared gene product. Evidence concerning one shared entity reports that a Cbl family E3 ubiquitin ligase constitutively binds Grb2 and becomes associated with Crk-L upon TCR stimulation. Which protein is encoded by that entity? | E3 ubiquitin-protein ligase CBL-B | Medium | convergence | {"qa_id":"medium_convergence_01900","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRKL and PTK2 each interact with more than one shared gene product. Evidence concerning one shared entity reports that a Cbl family E3 ubiquitin ligase const... | |
medium_convergence_01901 | Hepacivirus C and Human mastadenovirus C both upregulate a specific gene. Experimental evidence for this shared target indicates a log2 fold change of 1.083 and an adjusted p-value of 3.357e-07. Which protein is encoded by this gene? | NBPF family member NBPF10 | Medium | convergence | {"qa_id":"medium_convergence_01901","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Human mastadenovirus C both upregulate a specific gene. Experimental evidence for this shared target indicates a log2 fold change of 1.083 ... | |
medium_convergence_01902 | NOX1 and NCF2 are both involved in multiple shared biological processes. One such shared process is supported by evidence stating: 'Using Nox1 siRNA, we show that Nox1-dependent superoxide production affects the migration of HT29-D4 colonic adenocarcinoma cells on collagen-I.' Which biological process is this shared en... | superoxide metabolic process | Medium | convergence | {"qa_id":"medium_convergence_01902","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NOX1 and NCF2 are both involved in multiple shared biological processes. One such shared process is supported by evidence stating: 'Using Nox1 siRNA, we show... | |
medium_convergence_01903 | CDK8 and MED1 both interact with a shared protein entity. Evidence regarding this entity states: 'Here we show that this activator-recruited cofactor (ARC) interacts directly with several different activators, including SREBP-1a, VP16 and the p65 subunit of NF-kappaB, and strongly enhances transcription directed by the... | Sterol regulatory element-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01903","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK8 and MED1 both interact with a shared protein entity. Evidence regarding this entity states: 'Here we show that this activator-recruited cofactor (ARC) i... | |
medium_convergence_01904 | HDAC1 and RBPJ share multiple interacting partners. One such shared partner is characterized by evidence stating: 'We show here that phosphorylation by PKC acts as a switch to determine whether this protein interacts with HDAC1 or PCAF.' Which cell type is this shared partner enriched in? | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | convergence | {"qa_id":"medium_convergence_01904","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and RBPJ share multiple interacting partners. One such shared partner is characterized by evidence stating: 'We show here that phosphorylation by PKC a... | |
medium_convergence_01905 | CENPA and BIRC5 share multiple protein interaction partners. One such shared partner is part of a complex described in the following evidence: 'Here, we show that CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of three new human centromere proteins (CENP-M, CENP-N an... | Centromere protein C | Medium | convergence | {"qa_id":"medium_convergence_01905","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPA and BIRC5 share multiple protein interaction partners. One such shared partner is part of a complex described in the following evidence: 'Here, we show... | |
medium_convergence_01907 | DDB1 and ERCC4 share interaction partners. One such partner is part of a complex described in the context of Transcription-Coupled Nucleotide Excision Repair (TC-NER), where stalling of RNA polymerase II recruits factors including the [Entity]-DDB1-CUL4A-RBX1 cullin-RING ubiquitin ligase complex. Which protein is encod... | DNA excision repair protein ERCC-8 | Medium | convergence | {"qa_id":"medium_convergence_01907","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DDB1 and ERCC4 share interaction partners. One such partner is part of a complex described in the context of Transcription-Coupled Nucleotide Excision Repair... | |
medium_convergence_01909 | MCM7 and MYC both interact with a shared protein. Evidence regarding one such shared partner states: 'We identified minichromosome maintenance 7 (Mcm7), an essential component of the pre-replication complex, as a novel Smc1-interacting protein.' Which protein is encoded by the gene corresponding to this shared partner? | Structural maintenance of chromosomes protein 1A | Medium | convergence | {"qa_id":"medium_convergence_01909","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MCM7 and MYC both interact with a shared protein. Evidence regarding one such shared partner states: 'We identified minichromosome maintenance 7 (Mcm7), an e... | |
medium_convergence_01911 | UBC and VCP each interact with more than one shared gene product. Evidence concerning one such shared entity states: 'Here, we show that the protein encoded by ASPSCR1 is a cofactor of the hexameric ATPase complex, known as p97 or VCP in mammals and Cdc48 in yeast.' Which molecular function is enabled by that entity? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_01911","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBC and VCP each interact with more than one shared gene product. Evidence concerning one such shared entity states: 'Here, we show that the protein encoded ... | |
medium_convergence_01912 | FANCA and FAAP24 each interact with more than one shared protein. Evidence concerning one such shared entity states: 'Here, we show that this protein forms a conserved DNA-remodeling complex with a histone-fold heterodimer, MHF.' Which protein is encoded by the gene corresponding to that entity? | Fanconi anemia group M protein | Medium | convergence | {"qa_id":"medium_convergence_01912","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCA and FAAP24 each interact with more than one shared protein. Evidence concerning one such shared entity states: 'Here, we show that this protein forms a... | |
medium_convergence_01913 | ERBB2 and FGFR1 share a common interaction partner. Evidence indicates that the c-erbB-2 gene product associates directly with both beta-catenin and plakoglobin through its cytoplasmic domain core region. Which protein is encoded by the gene corresponding to this shared interaction partner? | Junction plakoglobin | Medium | convergence | {"qa_id":"medium_convergence_01913","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB2 and FGFR1 share a common interaction partner. Evidence indicates that the c-erbB-2 gene product associates directly with both beta-catenin and plakoglo... | |
medium_convergence_01914 | RIPK1 and FADD share a common binding partner. Evidence indicates that this shared entity interacts with both receptors, specifically noting its interaction with TRADD and RIP. Which protein is encoded by this shared entity? | Tumor necrosis factor receptor superfamily member 10B | Medium | convergence | {"qa_id":"medium_convergence_01914","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RIPK1 and FADD share a common binding partner. Evidence indicates that this shared entity interacts with both receptors, specifically noting its interaction ... | |
medium_convergence_01915 | NOX1 and RAC1 are both involved in multiple shared biological processes. One such shared process is supported by evidence stating: 'Using Nox1 siRNA, we show that Nox1-dependent superoxide production affects the migration of HT29-D4 colonic adenocarcinoma cells on collagen-I.' Which biological process, connected to thi... | superoxide metabolic process | Medium | convergence | {"qa_id":"medium_convergence_01915","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NOX1 and RAC1 are both involved in multiple shared biological processes. One such shared process is supported by evidence stating: 'Using Nox1 siRNA, we show... | |
medium_convergence_01916 | Human betaherpesvirus 5 and Rhinovirus A both downregulate a specific gene. Evidence for this gene's downregulation in a foreskin fibroblast cell line reports a log2 fold change of -1.299 and an adjusted p-value of 2.157e-05. Which cell type is this gene enriched in? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_01916","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Rhinovirus A both downregulate a specific gene. Evidence for this gene's downregulation in a foreskin fibroblast cell line report... | |
medium_convergence_01917 | Both Human immunodeficiency virus 1 and Dengue virus are reported to downregulate a specific gene. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately -1.322 and an adjusted p-value of 0.0002311. Which protein is encoded by this gene? | N-chimaerin | Medium | convergence | {"qa_id":"medium_convergence_01917","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus are reported to downregulate a specific gene. In a study of macrophages (GSE108897), this gene exhibited... | |
medium_convergence_01918 | Nucleolin (NCL) and Nucleophosmin 1 (NPM1) share multiple interacting partners. One such shared partner is implicated in a study stating: 'Here, we show that a specific protein forms a complex with B23, and this complex plays a critical role in cell proliferation and survival.' Which biological process is this specific... | negative regulation of DNA-templated transcription | Medium | convergence | {"qa_id":"medium_convergence_01918","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Nucleolin (NCL) and Nucleophosmin 1 (NPM1) share multiple interacting partners. One such shared partner is implicated in a study stating: 'Here, we show that... | |
medium_convergence_01919 | SMG1 and MTOR both interact with a specific protein. Experimental evidence indicates that this protein binds to the HEAT repeat segments of ATM and MTOR. Which protein is encoded by the gene corresponding to this interacting partner? | Telomere length regulation protein TEL2 homolog | Medium | convergence | {"qa_id":"medium_convergence_01919","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMG1 and MTOR both interact with a specific protein. Experimental evidence indicates that this protein binds to the HEAT repeat segments of ATM and MTOR. Whi... | |
medium_convergence_01920 | Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) shows a log2 fold change of -2.824 and an adjusted p-value of 0.01435. Which disease is associated with this gene as a biomarker? | congenital heart disease | Medium | convergence | {"qa_id":"medium_convergence_01920","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study G... | |
medium_convergence_01921 | Human respirovirus 3 and Human immunodeficiency virus 1 both upregulate a specific gene. Evidence for this shared target in a non-small cell lung adenocarcinoma cell line (study GSE147507) reports a log2 fold change of approximately 1.229 and an adjusted p-value of 0.04727. Which protein is encoded by this gene? | DNA-directed RNA polymerase III subunit RPC7 | Medium | convergence | {"qa_id":"medium_convergence_01921","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human respirovirus 3 and Human immunodeficiency virus 1 both upregulate a specific gene. Evidence for this shared target in a non-small cell lung adenocarcin... | |
medium_convergence_01922 | GAS6 and IL10 are both involved in a shared biological process. Evidence indicates that for one of these shared processes, the role of gamma-carboxylation is critical: specifically, only carboxylated GAS6 (not decarboxylated GAS6) protects endothelial cells from serum starvation-induced apoptosis. Which biological proc... | endothelial cell apoptotic process | Medium | convergence | {"qa_id":"medium_convergence_01922","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GAS6 and IL10 are both involved in a shared biological process. Evidence indicates that for one of these shared processes, the role of gamma-carboxylation is... | |
medium_convergence_01923 | CRK and EGFR share a common interaction partner. Evidence regarding this shared entity states: 'Finally, the 52 kDa Cbl-c protein binds to the EGF receptor and Fyn tyrosine kinase.' Which protein is encoded by the gene corresponding to this shared entity? | E3 ubiquitin-protein ligase CBL-C | Medium | convergence | {"qa_id":"medium_convergence_01923","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRK and EGFR share a common interaction partner. Evidence regarding this shared entity states: 'Finally, the 52 kDa Cbl-c protein binds to the EGF receptor a... | |
medium_convergence_01924 | The androgen receptor (AR) and the retinoblastoma protein (RB1) share common interacting partners. One such shared partner is described in evidence stating that both RNF20 and this partner were able to functionally and physically interact with AR and modulate its transcriptional activity in intact cells. Which protein ... | E3 ubiquitin-protein ligase BRE1B | Medium | convergence | {"qa_id":"medium_convergence_01924","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The androgen receptor (AR) and the retinoblastoma protein (RB1) share common interacting partners. One such shared partner is described in evidence stating t... | |
medium_convergence_01925 | AMFR and VCP both interact with a specific protein. Evidence indicates that the polyubiquitylation of this protein in vitro depends on a physical interaction between the CUE domain of gp78 and its ubiquitin-like (UBL) domain, a process essential for its degradation in vivo during ER stress recovery. Which disease is as... | alcohol abuse | Medium | convergence | {"qa_id":"medium_convergence_01925","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AMFR and VCP both interact with a specific protein. Evidence indicates that the polyubiquitylation of this protein in vitro depends on a physical interaction... | |
medium_convergence_01926 | DLAT and MRPL58 share common interacting partners. One such shared partner exhibits very tight binding that persists during the isolation of its complexes with the L2 subunit via size-exclusion chromatography. Which protein is encoded by this specific shared partner? | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial | Medium | convergence | {"qa_id":"medium_convergence_01926","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLAT and MRPL58 share common interacting partners. One such shared partner exhibits very tight binding that persists during the isolation of its complexes wi... | |
medium_convergence_01927 | ARPC4 and CDC42 share a common binding partner. Experimental evidence regarding this partner indicates that mutations such as V42A and L174A cause large, selective changes in binding to specific CRIB effectors. Specifically, neither mutation alters PAK binding, both severely disrupt binding to ACK, and only the L174A m... | Actin nucleation-promoting factor WAS | Medium | convergence | {"qa_id":"medium_convergence_01927","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARPC4 and CDC42 share a common binding partner. Experimental evidence regarding this partner indicates that mutations such as V42A and L174A cause large, sel... | |
medium_convergence_01928 | LAMTOR2 and ATP6V1D each interact with more than one shared protein. Evidence concerning one of these shared entities describes it as an uncharacterized protein with sequence similarity to amino acid transporters, functioning as a lysosomal transmembrane protein that interacts with the Rag guanosine triphosphatases (GT... | Neutral amino acid transporter 9 | Medium | convergence | {"qa_id":"medium_convergence_01928","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LAMTOR2 and ATP6V1D each interact with more than one shared protein. Evidence concerning one of these shared entities describes it as an uncharacterized prot... | |
medium_convergence_01929 | ANAPC15 and CDC16 share a common binding partner. Evidence indicates that in extracts prepared from M phase, but not from interphase HeLa cells, p55CDC coimmunoprecipitates with three important elements of the M phase checkpoint machinery: the shared entity, Cdc16, and Mad2. Which protein is encoded by that shared enti... | Cell division cycle protein 27 homolog | Medium | convergence | {"qa_id":"medium_convergence_01929","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC15 and CDC16 share a common binding partner. Evidence indicates that in extracts prepared from M phase, but not from interphase HeLa cells, p55CDC coimm... | |
medium_convergence_01930 | The biological processes 'regulation of antimicrobial humoral response' and 'regulation of defense response to fungus' share a common parent process in the ontology hierarchy. Evidence for one of these shared parent processes states: 'Any process that modulates the frequency, rate, or extent of an antimicrobial humoral... | response to biotic stimulus | Medium | convergence | {"qa_id":"medium_convergence_01930","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The biological processes 'regulation of antimicrobial humoral response' and 'regulation of defense response to fungus' share a common parent process in the o... | |
medium_convergence_01931 | Primate erythroparvovirus 1 and Primate bocaparvovirus 1 each upregulate more than one shared gene. Evidence concerning one such shared entity reports a log2 fold change of 1.023 and an adjusted p-value of 0.04293. Which disease is connected to that entity through genomic alterations? | myelodysplastic syndrome | Medium | convergence | {"qa_id":"medium_convergence_01931","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Primate erythroparvovirus 1 and Primate bocaparvovirus 1 each upregulate more than one shared gene. Evidence concerning one such shared entity reports a log2... | |
medium_convergence_01932 | STIP1 and DNAJB1 both interact with a shared gene product. Evidence indicates that this shared entity is associated with a specific renal tubulopathy, alongside the cochaperones CHIP and the Hsp70/Hsp90 organizer protein. Which protein is encoded by this shared gene? | Solute carrier family 12 member 3 | Medium | convergence | {"qa_id":"medium_convergence_01932","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STIP1 and DNAJB1 both interact with a shared gene product. Evidence indicates that this shared entity is associated with a specific renal tubulopathy, alongs... | |
medium_convergence_01933 | SIN3A and SP1 both interact with a shared protein. Evidence indicates that this shared protein is associated with the corepressor mSin3A in murine erythroleukemia (MEL) and human T-ALL cells. Which protein is encoded by this shared entity? | T-cell acute lymphocytic leukemia protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01933","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIN3A and SP1 both interact with a shared protein. Evidence indicates that this shared protein is associated with the corepressor mSin3A in murine erythroleu... | |
medium_convergence_01935 | The biological processes 'positive regulation of sarcomere organization' and 'positive regulation of cardiac myofibril assembly' share a common parent process. Evidence regarding this shared entity states: 'Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyos... | cytoskeleton organization | Medium | convergence | {"qa_id":"medium_convergence_01935","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The biological processes 'positive regulation of sarcomere organization' and 'positive regulation of cardiac myofibril assembly' share a common parent proces... | |
medium_convergence_01936 | Both Hepacivirus C and Zaire ebolavirus are associated with the upregulation of a specific gene. Experimental data for this gene reports a log2 fold change of approximately 1.12 and an adjusted p-value of 0.0113. Which biological process is this gene involved in? | positive regulation of protein localization | Medium | convergence | {"qa_id":"medium_convergence_01936","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Hepacivirus C and Zaire ebolavirus are associated with the upregulation of a specific gene. Experimental data for this gene reports a log2 fold change o... | |
medium_convergence_01938 | CDK9 and LRRK2 share common interacting partners. One such shared partner is described in evidence stating: 'Intriguingly, we found that LRRK2-GS localizes to the ER membrane, where it interacts with sarco/endoplasmic reticulum Ca.' Which protein is encoded by this shared interacting partner? | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | Medium | convergence | {"qa_id":"medium_convergence_01938","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK9 and LRRK2 share common interacting partners. One such shared partner is described in evidence stating: 'Intriguingly, we found that LRRK2-GS localizes t... | |
medium_convergence_01939 | ERBB2 and BTC share multiple binding partners. One such shared partner is associated with evidence stating: 'Here, we report that the expression of this kinase was observed in 70 out of 80 primary breast cancer specimens but not in normal breast tissues (0/19).' Which protein is encoded by this shared partner? | Megakaryocyte-associated tyrosine-protein kinase | Medium | convergence | {"qa_id":"medium_convergence_01939","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB2 and BTC share multiple binding partners. One such shared partner is associated with evidence stating: 'Here, we report that the expression of this kina... | |
medium_convergence_01940 | BMP6 and ACVR2B both interact with a specific receptor protein. Evidence indicates that BMP-6 weakly binds to BMPR-IA (also known as ALK-3), a receptor to which BMP-2 also binds. Which protein is encoded by the gene corresponding to this receptor? | Bone morphogenetic protein receptor type-1A | Medium | convergence | {"qa_id":"medium_convergence_01940","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMP6 and ACVR2B both interact with a specific receptor protein. Evidence indicates that BMP-6 weakly binds to BMPR-IA (also known as ALK-3), a receptor to wh... | |
medium_convergence_01941 | HCFC1 and KANSL3 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We demonstrate that a large proportion of the signaling enzyme O-linked-N-acetylglucosaminyl transferase is complexed with HCF-1 and this interaction is essential for HCF-1 cleavage.' Which disease is conne... | hepatocellular carcinoma | Medium | convergence | {"qa_id":"medium_convergence_01941","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HCFC1 and KANSL3 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We demonstrate that a large proportion of t... | |
medium_convergence_01942 | NEDD4 and YWHAG both interact with a shared protein. Evidence indicates that this shared protein, identified as CNrasGEF, possesses two PY motifs at its C-terminus responsible for binding to NEDD4 in vitro. Which protein is encoded by the gene corresponding to this shared entity? | Rap guanine nucleotide exchange factor 2 | Medium | convergence | {"qa_id":"medium_convergence_01942","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD4 and YWHAG both interact with a shared protein. Evidence indicates that this shared protein, identified as CNrasGEF, possesses two PY motifs at its C-te... | |
medium_convergence_01943 | PPP1CA and PPP1CC both interact with a specific shared protein. Evidence indicates that ATR and CHK1 kinase inhibitors induce Ser2205 phosphorylation of this protein in a CDK1-dependent manner, which disrupts its interaction with PP1 phosphatase. Which disease is associated with this protein as a biomarker? | fibrosarcoma | Medium | convergence | {"qa_id":"medium_convergence_01943","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PPP1CA and PPP1CC both interact with a specific shared protein. Evidence indicates that ATR and CHK1 kinase inhibitors induce Ser2205 phosphorylation of this... | |
medium_convergence_01944 | PPP2CA and PPP2CB each interact with more than one shared protein. Evidence concerning one such shared entity reports that the STRIPAK complex contains the PP2A catalytic (PP2Ac) and scaffolding (PP2A A) subunits, the striatins (PP2A regulatory B''' subunits), the striatin-associated protein Mob3, the novel proteins ST... | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform | Medium | convergence | {"qa_id":"medium_convergence_01944","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PPP2CA and PPP2CB each interact with more than one shared protein. Evidence concerning one such shared entity reports that the STRIPAK complex contains the P... | |
medium_convergence_01945 | SMC4 and TRIM28 both interact with a specific protein. Evidence indicates that the Lys44, Lys56, and Lys68 residues on this protein are SUMOylated by TRIM28, a modification that inhibits the protein's kinase activity or prevents P-TEFb assembly by directly blocking the interaction between this protein and Cyclin T1. Wh... | Cyclin-dependent kinase 9 | Medium | convergence | {"qa_id":"medium_convergence_01945","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMC4 and TRIM28 both interact with a specific protein. Evidence indicates that the Lys44, Lys56, and Lys68 residues on this protein are SUMOylated by TRIM28,... | |
medium_convergence_01946 | ORC1 and CDC7 share multiple binding partners. One of these shared partners is described by evidence stating: 'Further analyses indicate that this protein physically interacts with ORC1 on non-chromatin nuclear structures.' Which disease is associated with this specific shared partner? | Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome | Medium | convergence | {"qa_id":"medium_convergence_01946","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ORC1 and CDC7 share multiple binding partners. One of these shared partners is described by evidence stating: 'Further analyses indicate that this protein ph... | |
medium_convergence_01947 | Dengue virus and Enterovirus A both upregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold change of approximately 1.109 and an adjusted p-value of approximately 0.03026. Which disease is associated with this gene as a biomarker? | non-small cell lung carcinoma | Medium | convergence | {"qa_id":"medium_convergence_01947","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Enterovirus A both upregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold... | |
medium_convergence_01948 | ANAPC10 and ANAPC11 both physically associate with a common protein partner. Experimental evidence indicates that this shared partner contains a C-terminal cullin homology domain that binds APC11 and UbcH10, distinguishing it from other potential partners. Which gene product is known to interact with this specific shar... | TP63 | Medium | convergence | {"qa_id":"medium_convergence_01948","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC10 and ANAPC11 both physically associate with a common protein partner. Experimental evidence indicates that this shared partner contains a C-terminal c... | |
medium_convergence_01949 | BABAM1 and PTEN both interact with a specific protein. Evidence indicates that MERIT40, a core component of the BRISC complex, directly interacts with the RXXPEG motif in the ARC-V domain of this protein (identified as Tankyrase1). Which protein is encoded by the gene corresponding to this entity? | Poly [ADP-ribose] polymerase tankyrase-1 | Medium | convergence | {"qa_id":"medium_convergence_01949","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BABAM1 and PTEN both interact with a specific protein. Evidence indicates that MERIT40, a core component of the BRISC complex, directly interacts with the RX... | |
medium_convergence_01950 | XRCC6 and PPP1CA both interact with a specific shared protein. Evidence indicates that ATR and CHK1 kinase inhibitors induce Ser2205 phosphorylation of this shared protein in a CDK1-dependent manner, an event that disrupts the interaction between this protein and PP1 phosphatase. Which protein is encoded by the gene co... | Telomere-associated protein RIF1 | Medium | convergence | {"qa_id":"medium_convergence_01950","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"XRCC6 and PPP1CA both interact with a specific shared protein. Evidence indicates that ATR and CHK1 kinase inhibitors induce Ser2205 phosphorylation of this ... | |
medium_convergence_01951 | DAB1 and LRP8 both interact with a shared protein that belongs to the family of JNK-interacting proteins (JIPs), which function as molecular scaffolds for the JNK-signaling pathway. Which disease is associated with this specific shared protein? | cervical carcinoma | Medium | convergence | {"qa_id":"medium_convergence_01951","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAB1 and LRP8 both interact with a shared protein that belongs to the family of JNK-interacting proteins (JIPs), which function as molecular scaffolds for th... | |
medium_convergence_01952 | COPS4 and COPS3 both interact with a shared protein partner. Evidence regarding this partner states: 'The subcomplex is stabilized by three types of interactions: MPN-MPN between CSN5 and CSN6, PCI-PCI between CSN4 and CSN7, and interactions mediated through the CSN6 C terminus with CSN4 and CSN7.' Which protein is enc... | COP9 signalosome complex subunit 7a | Medium | convergence | {"qa_id":"medium_convergence_01952","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS4 and COPS3 both interact with a shared protein partner. Evidence regarding this partner states: 'The subcomplex is stabilized by three types of interact... | |
medium_convergence_01953 | BMP4 and GDF5 both interact with a specific receptor protein. Experimental evidence indicates that BMP-4 binds to ALK-3 in MC3T3-E1 osteoblasts and human foreskin fibroblasts. Which protein is encoded by the gene corresponding to this receptor? | Bone morphogenetic protein receptor type-1A | Medium | convergence | {"qa_id":"medium_convergence_01953","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMP4 and GDF5 both interact with a specific receptor protein. Experimental evidence indicates that BMP-4 binds to ALK-3 in MC3T3-E1 osteoblasts and human for... | |
medium_convergence_01954 | HSP90AA1 and PRKN (also known as PARK2) share multiple interacting partners. One of these shared partners is reported to form a complex with several other nuclear receptors, basic helix-loop-helix/Per-Arnt-Sim proteins, and heat-shock protein 90 (HSP90). Which disease is associated with this specific shared partner? | Perrault syndrome 7 | Medium | convergence | {"qa_id":"medium_convergence_01954","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSP90AA1 and PRKN (also known as PARK2) share multiple interacting partners. One of these shared partners is reported to form a complex with several other nu... | |
medium_convergence_01955 | NEDD4 and ITCH both interact with a specific shared protein. Evidence regarding this protein states: 'To bring insights into the biochemical function of human LITAF, we confirmed that human LITAF interacts with NEDD4 and also report a novel interaction with tumor susceptibility gene 101 (TSG101), a class E vacuolar sor... | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_01955","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD4 and ITCH both interact with a specific shared protein. Evidence regarding this protein states: 'To bring insights into the biochemical function of huma... | |
medium_convergence_01956 | STUB1 and YAP1 both interact with a specific protein. Evidence indicates that this protein directly phosphorylates YAP1 at tyrosine residue 357 in response to DNA damage. Which protein is encoded by the gene corresponding to this interacting partner? | Tyrosine-protein kinase ABL1 | Medium | convergence | {"qa_id":"medium_convergence_01956","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and YAP1 both interact with a specific protein. Evidence indicates that this protein directly phosphorylates YAP1 at tyrosine residue 357 in response t... | |
medium_convergence_01957 | Interferon gamma-1b and Rituximab share a common drug interaction partner. Clinical evidence indicates that adding this shared entity to a regimen of etoposide and the entity itself significantly improves CD34+ cell yield (9.9 vs 5.6 × 10^6/kg; P = .021). Which disease is this shared entity indicated for? | acute myeloid leukemia | Medium | convergence | {"qa_id":"medium_convergence_01957","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Interferon gamma-1b and Rituximab share a common drug interaction partner. Clinical evidence indicates that adding this shared entity to a regimen of etoposi... | |
medium_convergence_01958 | CDC45 and GINS1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'We found that CDC45 can directly interact with all MCM2-7 proteins; with PSF2, PSF3 and SLD5 in GINS subunits; and with replication protein A2 (RPA2), AND-1 and topoisomerase 2-binding protein 1... | DNA replication licensing factor MCM4 | Medium | convergence | {"qa_id":"medium_convergence_01958","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC45 and GINS1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'We found that CDC45 can directl... | |
medium_convergence_01959 | ATF7IP and H3C1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Notably, acetylated this protein binds to histone H3 phosphorylation at threonine 11 (H3T11P) and is essential for DNA damage-induced reduction of H3T11P and transcriptional repression of its downstream targ... | triple-negative breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_01959","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATF7IP and H3C1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Notably, acetylated this protein binds to hi... | |
medium_convergence_01960 | TP53 and UBA1 share multiple interacting partners. One such partner is described in evidence stating: 'Using surface plasmon resonance, we show here that HR6 protein (referred as Rad6) physically interacts with p53.' Which protein is encoded by the gene corresponding to this interacting partner? | Ubiquitin-conjugating enzyme E2 A | Medium | convergence | {"qa_id":"medium_convergence_01960","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TP53 and UBA1 share multiple interacting partners. One such partner is described in evidence stating: 'Using surface plasmon resonance, we show here that HR6... | |
medium_convergence_01961 | Rift Valley fever phlebovirus and Zika virus both upregulate a specific gene. Experimental data for this gene in SAEC cells (study GSE102481) reports a log2 fold change of 1.144 and an adjusted p-value of 0.005266. Which protein is encoded by this gene? | Gamma-interferon-inducible protein 16 | Medium | convergence | {"qa_id":"medium_convergence_01961","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rift Valley fever phlebovirus and Zika virus both upregulate a specific gene. Experimental data for this gene in SAEC cells (study GSE102481) reports a log2 ... | |
medium_convergence_01962 | BRD4 and ANLN both interact with a shared protein entity. Experimental evidence indicates that this entity is part of replication factor C (RFC), a conserved five-subunit complex essential for DNA replication, as demonstrated by coimmunoprecipitation experiments showing interactions with both endogenous and transfected... | Morimoto-Ryu-Malicdan neuromuscular syndrome | Medium | convergence | {"qa_id":"medium_convergence_01962","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD4 and ANLN both interact with a shared protein entity. Experimental evidence indicates that this entity is part of replication factor C (RFC), a conserved... | |
medium_convergence_01963 | NBN and RAD51 both interact with a common protein partner. Evidence indicates that in assays using purified components, phosphorylation of this shared partner by c-Abl enhances complex formation between the partner and RAD51, a process that cooperates with RAD51 in recombination and repair. Which disease is associated ... | cervical squamous cell carcinoma | Medium | convergence | {"qa_id":"medium_convergence_01963","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NBN and RAD51 both interact with a common protein partner. Evidence indicates that in assays using purified components, phosphorylation of this shared partne... | |
medium_convergence_01964 | EZH2 and FHL1 both interact with a specific shared protein. Evidence indicates that this shared protein interacts with EZH2 and is required for the stability of LSD1, HDAC1, DNMT1, β-CATENIN, or the shared protein/4 complex, via the recruitment of the deubiquitinase USP7. Which gene encodes this shared protein? | SMAD family member 2 | Medium | convergence | {"qa_id":"medium_convergence_01964","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EZH2 and FHL1 both interact with a specific shared protein. Evidence indicates that this shared protein interacts with EZH2 and is required for the stability... | |
medium_convergence_01965 | HUWE1 and KAT5 both interact with a shared protein. Experimental evidence indicates that Tip60 was identified as an interacting partner of this shared protein using yeast two-hybrid screening. Which cellular component is this shared protein located in? | chromatin | Medium | convergence | {"qa_id":"medium_convergence_01965","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HUWE1 and KAT5 both interact with a shared protein. Experimental evidence indicates that Tip60 was identified as an interacting partner of this shared protei... | |
medium_convergence_01966 | Interferon beta-1a and Bortezomib share a common interacting drug. Evidence indicates that the combined treatment of cells with this shared drug (abbreviated as VPA) and Bortezomib resulted in an additive killing effect. Which disease is this shared drug indicated for? | bipolar disorder | Medium | convergence | {"qa_id":"medium_convergence_01966","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Interferon beta-1a and Bortezomib share a common interacting drug. Evidence indicates that the combined treatment of cells with this shared drug (abbreviated... | |
medium_convergence_01967 | LETMD1 and HCK are both associated with multiple shared biological processes. One of these shared processes is linked to evidence stating: 'These findings reveal a previously unknown function of LETMD1 and provide evidences showing LETMD1 negatively regulates macrophage functions by modulating mitochondrial function, s... | inflammatory response | Medium | convergence | {"qa_id":"medium_convergence_01967","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LETMD1 and HCK are both associated with multiple shared biological processes. One of these shared processes is linked to evidence stating: 'These findings re... | |
medium_convergence_01968 | Dexbrompheniramine and Cyproheptadine share a common interacting drug. Evidence regarding this shared drug indicates that myoclonic features were prevented by pretreatment with p-chlorophenylalanine, unaffected by alpha-methyl-p-tyrosine, and attenuated by methysergide, the drug itself, clozapine, or pimozide. Which di... | neurotic depression | Medium | convergence | {"qa_id":"medium_convergence_01968","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dexbrompheniramine and Cyproheptadine share a common interacting drug. Evidence regarding this shared drug indicates that myoclonic features were prevented b... | |
medium_convergence_01969 | CSNK1G3 and CTNNB1 share a common binding partner. Evidence indicates that this shared entity, also known by a synonym, functions as part of the SCF complex with Skp1 and Cullin1, specifically interacting with phosphorylated IkappaB and beta-catenin to target them for proteasome-dependent degradation. Which protein is ... | F-box/WD repeat-containing protein 11 | Medium | convergence | {"qa_id":"medium_convergence_01969","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK1G3 and CTNNB1 share a common binding partner. Evidence indicates that this shared entity, also known by a synonym, functions as part of the SCF complex ... | |
medium_convergence_01970 | CSF1 and GRB2 both interact with a specific shared protein. Evidence regarding this shared entity states: 'By using an independent approach, expression cloning, we found that the [entity's] SH3 domains bind specifically to SIP-110, a 110 kDa splice variant of SIP-145 and SIP-130, which lacks the SH2 domain.' Which cell... | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_01970","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSF1 and GRB2 both interact with a specific shared protein. Evidence regarding this shared entity states: 'By using an independent approach, expression cloni... | |
medium_convergence_01971 | Rhinovirus A and Human gammaherpesvirus 8 both downregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) shows a log2 fold change of approximately -2.39 and an adjusted p-value of approximately 0.041. Which disease is associated with this gene? | diabetes mellitus | Medium | convergence | {"qa_id":"medium_convergence_01971","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Human gammaherpesvirus 8 both downregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475... | |
medium_convergence_01972 | DUX4 and DDX3X share multiple interacting partners. One such shared partner is an RNA-binding protein that was experimentally validated (via co-immunoprecipitation, co-immunofluorescence, and in situ Proximity Ligation Assay) as a DUX4/4c partner, alongside C1QBP, SRSF9, RBM3, and SFPQ, due to its role in mRNA splicing... | RNA-binding protein FUS | Medium | convergence | {"qa_id":"medium_convergence_01972","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DUX4 and DDX3X share multiple interacting partners. One such shared partner is an RNA-binding protein that was experimentally validated (via co-immunoprecipi... |
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