qa_id stringlengths 24 32 | question stringlengths 156 1.14k | answer stringlengths 3 134 | level stringclasses 1
value | subtype stringclasses 3
values | source_medium_qa_id stringclasses 1
value | record_json stringlengths 13.6k 214k |
|---|---|---|---|---|---|---|
medium_convergence_03198 | MIB1 and CALM1 each interact with more than one shared protein. Evidence concerning one such shared entity states: 'We show that EHD1 regulates the ubiquitination of a centriolar protein during ciliogenesis, and identify two E3 ubiquitin ligases, HECT domain and RCC1-like domain 2 (HERC2) and mindbomb homolog 1 (MIB1),... | Centriolar coiled-coil protein of 110 kDa | Medium | convergence | {"qa_id":"medium_convergence_03198","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MIB1 and CALM1 each interact with more than one shared protein. Evidence concerning one such shared entity states: 'We show that EHD1 regulates the ubiquitin... | |
medium_convergence_03199 | YAP1 and EP300 share multiple interacting partners. One such shared partner is described by evidence stating that its binding to Yes-associated protein 1 (YAP1) influences YAP1 stability, and that silencing this partner inhibits YAP1 expression by promoting its ubiquitination and degradation in cardiac fibroblasts. Whi... | Nucleosome assembly protein 1-like 1 | Medium | convergence | {"qa_id":"medium_convergence_03199","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and EP300 share multiple interacting partners. One such shared partner is described by evidence stating that its binding to Yes-associated protein 1 (YA... | |
medium_convergence_03201 | BIRC2 and BIRC3 both interact with a shared protein target. Evidence indicates that a cIAP1/cIAP2/TRAF2 E3 ligase complex binds to and ubiquitinates IKKε. Which protein, encoded by the gene corresponding to this shared target, is the subject of this interaction? | Inhibitor of nuclear factor kappa-B kinase subunit epsilon | Medium | convergence | {"qa_id":"medium_convergence_03201","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC2 and BIRC3 both interact with a shared protein target. Evidence indicates that a cIAP1/cIAP2/TRAF2 E3 ligase complex binds to and ubiquitinates IKKε. Wh... | |
medium_convergence_03202 | Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are reported to downregulate a specific host gene. Experimental data from a melanoma cell line study (GSE136586) indicates that this gene exhibits a log2 fold change of -1.020 and an adjusted p-value of 8.088e-06. What molecular fun... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_03202","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are reported to downregulate a specific host gene. Experimental data ... | |
medium_convergence_03203 | Both CDC37 and RET interact with a common protein. Experimental evidence indicates that this shared partner interacts specifically with RET in mammalian cell lines and in vivo in the pituitary gland, regardless of the presence of pituitary adenoma-specific mutations. Which protein is encoded by this shared partner? | AH receptor-interacting protein | Medium | convergence | {"qa_id":"medium_convergence_03203","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both CDC37 and RET interact with a common protein. Experimental evidence indicates that this shared partner interacts specifically with RET in mammalian cell... | |
medium_convergence_03204 | MYC and NFKB1 both interact with a shared protein. Evidence for the interaction between NFKB1 and this shared protein includes yeast two-hybrid assays, glutathione S-transferase pull-downs, and coimmunoprecipitation analyses. Which protein is encoded by this shared gene? | Splicing factor 1 | Medium | convergence | {"qa_id":"medium_convergence_03204","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and NFKB1 both interact with a shared protein. Evidence for the interaction between NFKB1 and this shared protein includes yeast two-hybrid assays, gluta... | |
medium_convergence_03205 | PCNA and RPA3 both interact with a specific shared protein. Evidence regarding this shared protein states: 'In vitro biochemical analysis demonstrated that these two proteins associate directly, with the interaction being mediated by residues between amino acids 166 and 310 of this protein.' Which protein is encoded by... | DNA repair protein XRCC1 | Medium | convergence | {"qa_id":"medium_convergence_03205","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PCNA and RPA3 both interact with a specific shared protein. Evidence regarding this shared protein states: 'In vitro biochemical analysis demonstrated that t... | |
medium_convergence_03206 | CREBBP and MYC each interact with more than one shared protein. Evidence concerning one of these shared proteins states: 'Coimmunoprecipitation assays showed that this protein and Myc associate with distinct domains of KDM5B and the C-terminal 270 amino acids (aa) of this protein are required for Myc and KDM5B interact... | Transcription factor AP-2 gamma | Medium | convergence | {"qa_id":"medium_convergence_03206","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and MYC each interact with more than one shared protein. Evidence concerning one of these shared proteins states: 'Coimmunoprecipitation assays showed... | |
medium_convergence_03209 | FOXM1 and MYC share common interacting partners. One such shared partner is characterized by a mechanism study in gastric cancer showing that it directly ubiquitinates FOXM1, thereby decreasing the FOXM1 transcriptional network and suppressing cancer cell proliferation and invasion. Which protein is encoded by this sha... | RING finger protein 112 | Medium | convergence | {"qa_id":"medium_convergence_03209","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FOXM1 and MYC share common interacting partners. One such shared partner is characterized by a mechanism study in gastric cancer showing that it directly ubi... | |
medium_convergence_03210 | FAN1 and ATRIP both interact with a specific protein involved in the Fanconi anemia pathway. Evidence indicates that the link of KIAA1018 to this pathway is strengthened by its recruitment to DNA damage sites through the interaction of its UBZ domain with the monoubiquitylated form of this protein. Which protein is enc... | Fanconi anemia group D2 protein | Medium | convergence | {"qa_id":"medium_convergence_03210","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FAN1 and ATRIP both interact with a specific protein involved in the Fanconi anemia pathway. Evidence indicates that the link of KIAA1018 to this pathway is ... | |
medium_convergence_03211 | MCM2 and MCM6 both interact with a shared protein partner. Experimental evidence indicates that this partner, when co-expressed in insect cells, interacts with individual MCM proteins 2 through 7 and significantly enhances the recovery of certain recombinant MCM proteins. Which protein is encoded by the gene correspond... | Mini-chromosome maintenance complex-binding protein | Medium | convergence | {"qa_id":"medium_convergence_03211","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MCM2 and MCM6 both interact with a shared protein partner. Experimental evidence indicates that this partner, when co-expressed in insect cells, interacts wi... | |
medium_convergence_03212 | E2F1 and RB1 both interact with a specific protein. Evidence indicates that Rb associates with this protein and HP1 in vivo via its pocket domain. Which protein is encoded by the gene corresponding to this interaction partner? | Histone-lysine N-methyltransferase SUV39H1 | Medium | convergence | {"qa_id":"medium_convergence_03212","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"E2F1 and RB1 both interact with a specific protein. Evidence indicates that Rb associates with this protein and HP1 in vivo via its pocket domain. Which prot... | |
medium_convergence_03213 | Bivalirudin and Alteplase both interact with a specific drug. Clinical evidence suggests that Platelet GP IIb/IIIa receptor antagonists may be suitable as a single therapeutic or as an adjunct to thrombolysis with this specific drug for the treatment of stroke. Which disease is this specific drug indicated for? | acute coronary syndrome | Medium | convergence | {"qa_id":"medium_convergence_03213","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Bivalirudin and Alteplase both interact with a specific drug. Clinical evidence suggests that Platelet GP IIb/IIIa receptor antagonists may be suitable as a ... | |
medium_convergence_03214 | MICU1 and MCUB are both involved in more than one shared biological process. Evidence indicates that one of these shared processes involves an entity required to preserve normal mitochondrial calcium concentration ([Ca2+](m)) under basal conditions. Which biological process is connected to that entity through an 'is a'... | intracellular calcium ion homeostasis | Medium | convergence | {"qa_id":"medium_convergence_03214","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MICU1 and MCUB are both involved in more than one shared biological process. Evidence indicates that one of these shared processes involves an entity require... | |
medium_convergence_03215 | FANCG and FAAP100 both interact with a specific protein that links the Fanconi anemia core complex to the Notch1 developmental pathway via a direct protein-protein interaction with hairy enhancer of split 1. Which protein is encoded by the gene corresponding to this interaction partner? | Transcription factor HES-1 | Medium | convergence | {"qa_id":"medium_convergence_03215","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCG and FAAP100 both interact with a specific protein that links the Fanconi anemia core complex to the Notch1 developmental pathway via a direct protein-p... | |
medium_convergence_03216 | ANAPC7 and BUB1B each interact with more than one shared protein. Evidence concerning one shared entity reports that a human protein also binds APC16 and APC7 and contains a >200-residue loop that is heavily phosphorylated during mitosis, although the basis for its interactions and whether loop phosphorylation is requi... | Cell division cycle protein 27 homolog | Medium | convergence | {"qa_id":"medium_convergence_03216","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC7 and BUB1B each interact with more than one shared protein. Evidence concerning one shared entity reports that a human protein also binds APC16 and APC... | |
medium_convergence_03217 | H2AX and ATM both interact with a shared protein. Evidence indicates that this shared protein forms complexes with phosphorylated H2AX. Which disease is associated with this shared protein? | telangiectasis | Medium | convergence | {"qa_id":"medium_convergence_03217","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"H2AX and ATM both interact with a shared protein. Evidence indicates that this shared protein forms complexes with phosphorylated H2AX. Which disease is asso... | |
medium_convergence_03218 | BUB1B and B9D2 each interact with more than one shared protein. Evidence concerning one shared entity states: 'We call this factor the mitotic checkpoint complex (MCC) as it consists of hBUBR1, hBUB3, CDC20, and MAD2 checkpoint proteins in near equal stoichiometry.' Which protein is encoded by that entity? | Mitotic checkpoint protein BUB3 | Medium | convergence | {"qa_id":"medium_convergence_03218","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BUB1B and B9D2 each interact with more than one shared protein. Evidence concerning one shared entity states: 'We call this factor the mitotic checkpoint com... | |
medium_convergence_03219 | NLGN4Y and DLGAP1 both interact with a shared protein partner. Experimental evidence regarding this partner states: 'Using the PDZ domains of ProSAP1 and 2 as bait in the yeast two-hybrid system, we isolated several clones of the SAPAP/GKAP (SAP90/PSD-95-associated protein/guanylate kinase-associated protein) family.' ... | SH3 and multiple ankyrin repeat domains protein 3 | Medium | convergence | {"qa_id":"medium_convergence_03219","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NLGN4Y and DLGAP1 both interact with a shared protein partner. Experimental evidence regarding this partner states: 'Using the PDZ domains of ProSAP1 and 2 a... | |
medium_convergence_03220 | HIF1A and PIN1 share multiple interacting partners. One such shared partner has been shown to increase the nuclear translocation of HIF-1α when coexpressed in HEK293 cells and to interact with HIF-1α at the oxygen-dependent degradation domain (ODDD). Which protein is encoded by this shared interacting partner? | Runt-related transcription factor 2 | Medium | convergence | {"qa_id":"medium_convergence_03220","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HIF1A and PIN1 share multiple interacting partners. One such shared partner has been shown to increase the nuclear translocation of HIF-1α when coexpressed i... | |
medium_convergence_03221 | BMP2 and BMP6 each interact with more than one shared receptor. Evidence concerning one such shared entity describes it as a transmembrane serine/threonine kinase that binds BMP-2 and BMP-7 in association with multiple type I receptors, including BMPR-IA/Brk1, BMPR-IB, and ActR-I. Which protein is encoded by the gene c... | Bone morphogenetic protein receptor type-2 | Medium | convergence | {"qa_id":"medium_convergence_03221","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMP2 and BMP6 each interact with more than one shared receptor. Evidence concerning one such shared entity describes it as a transmembrane serine/threonine k... | |
medium_convergence_03222 | GIGYF1 and YWHAE both interact with a shared protein partner. Evidence indicates that this partner, similar to TTP, harbors three proline-rich motifs that bind the GYF domain of GIGYF1. Which protein is encoded by this shared partner? | E3 ubiquitin-protein ligase ZNF598 | Medium | convergence | {"qa_id":"medium_convergence_03222","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GIGYF1 and YWHAE both interact with a shared protein partner. Evidence indicates that this partner, similar to TTP, harbors three proline-rich motifs that bi... | |
medium_convergence_03223 | Morphine and Fenfluramine share a common interacting drug. Evidence indicates that combination treatment with sub-effective doses of this shared entity (0.1 mg/kg) and morphine (0.1 mg/kg) significantly (p < 0.05) exerted an anti-convulsive effect. Which disease is this shared entity indicated for? | cluster headache syndrome | Medium | convergence | {"qa_id":"medium_convergence_03223","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Morphine and Fenfluramine share a common interacting drug. Evidence indicates that combination treatment with sub-effective doses of this shared entity (0.1 ... | |
medium_convergence_03224 | Erythromycin and Clemastine both interact with a specific shared drug. Evidence indicates that this shared drug belongs to a class of agents (phenothiazines) that interact synergistically with antimicrobials such as streptomycin, oleandomycin, spectinomycin, levofloxacin, azithromycin, and amoxicillin-clavulanic acid. ... | schizophrenia | Medium | convergence | {"qa_id":"medium_convergence_03224","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Erythromycin and Clemastine both interact with a specific shared drug. Evidence indicates that this shared drug belongs to a class of agents (phenothiazines)... | |
medium_convergence_03225 | COPB1 and COPG1 share interaction partners. One such shared partner was identified in a study reporting, for the first time, members of the coatomer I (COPI) complex as interaction partners of hSAC1. Which biological process is this specific shared partner involved in? | phosphatidylinositol dephosphorylation | Medium | convergence | {"qa_id":"medium_convergence_03225","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPB1 and COPG1 share interaction partners. One such shared partner was identified in a study reporting, for the first time, members of the coatomer I (COPI)... | |
medium_convergence_03226 | RABAC1 and KRAS both interact with a specific synaptic vesicle protein. Experimental evidence indicates that a prenylated Rab acceptor (PRA1) binds specifically to this protein (also known as synaptobrevin II) but shows no affinity for VAMP1 or cellubrevin in yeast two-hybrid and in vitro binding assays. Which protein ... | Vesicle-associated membrane protein 2 | Medium | convergence | {"qa_id":"medium_convergence_03226","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RABAC1 and KRAS both interact with a specific synaptic vesicle protein. Experimental evidence indicates that a prenylated Rab acceptor (PRA1) binds specifica... | |
medium_convergence_03227 | CTBP1 and CTNNB1 both interact with a specific transcriptional co-regulator. Experimental evidence indicates that when endogenous Smad7 is repressed by specific small interfering RNA, the TGF-beta-induced association between beta-catenin and this co-regulator is prevented. Which cell type is this co-regulator enriched ... | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | convergence | {"qa_id":"medium_convergence_03227","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTBP1 and CTNNB1 both interact with a specific transcriptional co-regulator. Experimental evidence indicates that when endogenous Smad7 is repressed by speci... | |
medium_convergence_03228 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 1.59 and an adjusted p-value of 0.006573. Which disease is associated with this gene as a biomarker? | karyomegalic interstitial nephritis | Medium | convergence | {"qa_id":"medium_convergence_03228","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (stud... | |
medium_convergence_03229 | ATG5 and IKBKE each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'We have previously shown that this entity recruits IkappaB kinase epsilon (IKKepsilon) but not TBK-1 to the mitochondria following viral infection.' Which disease is associated with that specific en... | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03229","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATG5 and IKBKE each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'We have previously shown that this ... | |
medium_convergence_03230 | AKT1 and ESR1 share a common interacting partner. Evidence indicates that Tamoxifen increases the interaction between this shared partner and the Estrogen Receptor (ER) in tamoxifen-resistant cells, but not in tamoxifen-sensitive cells. Which cell type is this shared partner enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_03230","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKT1 and ESR1 share a common interacting partner. Evidence indicates that Tamoxifen increases the interaction between this shared partner and the Estrogen Re... | |
medium_convergence_03231 | MAP1LC3B and MFN2 each share a binding partner with another protein. One such shared partner is described as interacting with ubiquitinated proteins and the autophagic marker light chain 3b (LC3b), thereby mediating the degradation of selective targets. Which protein is encoded by this shared partner? | Sequestosome-1 | Medium | convergence | {"qa_id":"medium_convergence_03231","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAP1LC3B and MFN2 each share a binding partner with another protein. One such shared partner is described as interacting with ubiquitinated proteins and the ... | |
medium_convergence_03232 | F8 and GOLGA2 each share a binding partner with another gene. Evidence concerning one such shared partner indicates that a Golgi reassembly-stacking protein exists in a complex with the vesicle docking protein receptor GM130, to which it binds directly, and with the membrane tethering protein p115, which also functions... | Golgi reassembly-stacking protein 1 | Medium | convergence | {"qa_id":"medium_convergence_03232","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"F8 and GOLGA2 each share a binding partner with another gene. Evidence concerning one such shared partner indicates that a Golgi reassembly-stacking protein ... | |
medium_convergence_03233 | SMAD1 and SMAD5 both interact with a specific shared protein. Evidence indicates that this shared protein specifically competes with Smad4 for binding to receptor-activated Smad1, resulting in an apparently inactive Smad1-protein complex. Which gene encodes this shared protein? | SMAD family member 6 | Medium | convergence | {"qa_id":"medium_convergence_03233","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD1 and SMAD5 both interact with a specific shared protein. Evidence indicates that this shared protein specifically competes with Smad4 for binding to rec... | |
medium_convergence_03234 | IPO7 and EGFR share common interaction partners. One such shared partner is physically associated with a protein encoded by the gene AKTIP and co-localizes with it in cells. Which protein is encoded by this shared partner? | AKT-interacting protein | Medium | convergence | {"qa_id":"medium_convergence_03234","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IPO7 and EGFR share common interaction partners. One such shared partner is physically associated with a protein encoded by the gene AKTIP and co-localizes w... | |
medium_convergence_03235 | EHMT2 and CBX3 share a common interaction partner. Evidence indicates that a histone H3K9-like mimic within this shared entity is methylated by G9a and GLP and, compared with H3K9me2/3, more avidly binds UHRF1. Which cell type is this entity enriched in? | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_03235","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EHMT2 and CBX3 share a common interaction partner. Evidence indicates that a histone H3K9-like mimic within this shared entity is methylated by G9a and GLP a... | |
medium_convergence_03236 | PARP1 and GSK3B share multiple interacting partners. One such partner is described in evidence stating: 'Mechanistic analysis further showed that it specifically interacts with poly(ADP-ribose) polymerase-1 (PARP-1), a nuclear enzyme important in DNA repair and apoptosis.' Which protein is encoded by this specific inte... | Krueppel-like factor 5 | Medium | convergence | {"qa_id":"medium_convergence_03236","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and GSK3B share multiple interacting partners. One such partner is described in evidence stating: 'Mechanistic analysis further showed that it specific... | |
medium_convergence_03237 | TRIM28 and CHD4 both interact with a specific shared protein. Evidence indicates that KAP1 (TRIM28) associates with several DNA replication factors, including PCNA, MCM3, and this shared protein. Which protein is encoded by the gene corresponding to this shared entity? | DNA replication licensing factor MCM6 | Medium | convergence | {"qa_id":"medium_convergence_03237","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and CHD4 both interact with a specific shared protein. Evidence indicates that KAP1 (TRIM28) associates with several DNA replication factors, includin... | |
medium_convergence_03238 | RHOB and RAC1 share multiple interacting partners. One such shared partner is described in a study reporting: 'Here we have determined the crystal structure of the DH and PH domains of the T-lymphoma invasion and metastasis factor 1 protein in complex with its cognate Rho family G protein, Rac1.' Which disease is assoc... | squamous cell carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03238","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RHOB and RAC1 share multiple interacting partners. One such shared partner is described in a study reporting: 'Here we have determined the crystal structure ... | |
medium_convergence_03239 | CENPS and CENPK each interact with more than one shared partner. Evidence concerning one shared entity reports that Fluorescent two-hybrid analysis identified this shared partner as a uniquely strong CENP-S binding protein, and this association was confirmed by FRET, revealing a centromere-bound complex containing CENP... | short stature and microcephaly with genital anomalies | Medium | convergence | {"qa_id":"medium_convergence_03239","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPS and CENPK each interact with more than one shared partner. Evidence concerning one shared entity reports that Fluorescent two-hybrid analysis identifie... | |
medium_convergence_03240 | SIN3A and HDAC1 share interaction partners. One such shared partner is described in literature as a novel mSin3A-interacting protein containing two plant homeodomain (PHD) zinc fingers, termed a PHD factor one homolog. Which disease is associated with this specific protein? | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03240","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIN3A and HDAC1 share interaction partners. One such shared partner is described in literature as a novel mSin3A-interacting protein containing two plant hom... | |
medium_convergence_03241 | FGF1 and FGF8 both interact with a specific protein receptor. Evidence regarding this interaction states: 'Within each 1:1 FGF:FGFR complex, heparin makes numerous contacts with both FGF and FGFR, thereby augmenting FGF-FGFR binding.' Which protein is encoded by the gene corresponding to this receptor? | Fibroblast growth factor receptor 1 | Medium | convergence | {"qa_id":"medium_convergence_03241","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FGF1 and FGF8 both interact with a specific protein receptor. Evidence regarding this interaction states: 'Within each 1:1 FGF:FGFR complex, heparin makes nu... | |
medium_convergence_03242 | DHX9 and WNT5A are both involved in more than one shared biological process. One of these shared processes is linked to evidence stating that the loss of the associated entity in primary human fibroblasts results in premature senescence, a state of irreversible growth arrest. Which biological process is positively regu... | fibroblast proliferation | Medium | convergence | {"qa_id":"medium_convergence_03242","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DHX9 and WNT5A are both involved in more than one shared biological process. One of these shared processes is linked to evidence stating that the loss of the... | |
medium_convergence_03243 | Primate erythroparvovirus 1 and Measles morbillivirus both upregulate a specific gene. Evidence for this gene in erythroid progenitor cells (from study GSE103460) reports a log2 fold change of 1.023 and an adjusted p-value of 0.04293. Which disease is associated with this gene through genomic alterations? | myelodysplastic syndrome | Medium | convergence | {"qa_id":"medium_convergence_03243","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Primate erythroparvovirus 1 and Measles morbillivirus both upregulate a specific gene. Evidence for this gene in erythroid progenitor cells (from study GSE10... | |
medium_convergence_03244 | HIF1A and EGLN1 both interact with a shared protein entity. Evidence indicates that TBP-1 associates with the beta-domain of this entity and forms a complex with it and HIF1 alpha in vivo. Which protein is encoded by the gene corresponding to this shared entity? | von Hippel-Lindau disease tumor suppressor | Medium | convergence | {"qa_id":"medium_convergence_03244","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HIF1A and EGLN1 both interact with a shared protein entity. Evidence indicates that TBP-1 associates with the beta-domain of this entity and forms a complex ... | |
medium_convergence_03245 | Zaire ebolavirus and Zika virus both downregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line (study GSE100839) reports a log2 fold change of approximately -1.042 and an adjusted p-value of 0.01859. Which protein is encoded by this gene? | Melanoregulin | Medium | convergence | {"qa_id":"medium_convergence_03245","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Zaire ebolavirus and Zika virus both downregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line (study GSE100839... | |
medium_convergence_03246 | SNF8 and TSG101 both interact with a common protein partner. Evidence regarding this partner states: 'The ability of HCRP1 (which we assign the alternative name hVps37A) to interact with Tsg101 is conferred by its mod(r) domain and is shared with hVps37B and hVps37C, two other mod(r) domain-containing proteins.' Which ... | Vacuolar protein sorting-associated protein 37B | Medium | convergence | {"qa_id":"medium_convergence_03246","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SNF8 and TSG101 both interact with a common protein partner. Evidence regarding this partner states: 'The ability of HCRP1 (which we assign the alternative n... | |
medium_convergence_03247 | Morphine and Hyoscyamine both interact with a specific drug. Evidence regarding this drug states: 'While tricyclics had no effect on basal pain responsivity, they potentiated morphine analgesia in rank-order with their potency as TLR4 inhibitors.' Which disease is this drug indicated for? | fibromyalgia | Medium | convergence | {"qa_id":"medium_convergence_03247","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Morphine and Hyoscyamine both interact with a specific drug. Evidence regarding this drug states: 'While tricyclics had no effect on basal pain responsivity,... | |
medium_convergence_03248 | ANKRD52 and PPP6C share multiple interacting partners. One such shared partner is described in the following evidence: 'Here we report that DNA-PKcs interacts with the catalytic subunits of PP6 (PP6c) and PP2A (PP2Ac), as well as with the PP6 regulatory subunits PP6R1, PP6R2, and PP6R3.' Which protein, among the shared... | Serine/threonine-protein phosphatase 6 regulatory subunit 2 | Medium | convergence | {"qa_id":"medium_convergence_03248","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANKRD52 and PPP6C share multiple interacting partners. One such shared partner is described in the following evidence: 'Here we report that DNA-PKcs interact... | |
medium_convergence_03249 | HDAC1 and ACTB share multiple binding partners. One such shared partner is known to regulate NF-kappaB activity indirectly, specifically through its association with HDAC1, rather than by interacting with NF-kappaB directly. Which protein is encoded by this shared partner? | Histone deacetylase 2 | Medium | convergence | {"qa_id":"medium_convergence_03249","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and ACTB share multiple binding partners. One such shared partner is known to regulate NF-kappaB activity indirectly, specifically through its associat... | |
medium_convergence_03250 | DNA2 and POLA1 both interact with a shared protein partner. Evidence regarding this partner states: 'We have identified a short conserved motif at the extreme C terminus of pol α that is critical for interaction of the yeast ortholog pol1 with primase.' Which protein is encoded by this shared partner? | DNA primase small subunit | Medium | convergence | {"qa_id":"medium_convergence_03250","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNA2 and POLA1 both interact with a shared protein partner. Evidence regarding this partner states: 'We have identified a short conserved motif at the extrem... | |
medium_convergence_03251 | FZD5 and AXIN1 share common binding partners. One such partner is described in evidence stating: 'we identified Axin as a protein that interacts with the intracellular domain of LRP-5.' Which protein is encoded by the gene corresponding to this specific shared partner? | Low-density lipoprotein receptor-related protein 5 | Medium | convergence | {"qa_id":"medium_convergence_03251","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FZD5 and AXIN1 share common binding partners. One such partner is described in evidence stating: 'we identified Axin as a protein that interacts with the int... | |
medium_convergence_03252 | KCND3 and KCNE1 both enable a shared molecular function. Evidence regarding one of these functions states: 'The human cardiac fast transient outward K+ channel is composed of the KV4.3 α subunit encoded by KCND3 and the K+ channel‑interacting protein 2 (KChIP2) β subunit, and determines the early repolarization of the ... | membrane repolarization during cardiac muscle cell action potential | Medium | convergence | {"qa_id":"medium_convergence_03252","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KCND3 and KCNE1 both enable a shared molecular function. Evidence regarding one of these functions states: 'The human cardiac fast transient outward K+ chann... | |
medium_convergence_03253 | ARPC2 and AP2M1 both interact with a shared protein partner. Evidence indicates that the NTA region of this partner interacts directly with the Arp2/3 complex, as demonstrated by affinity chromatography, immunoprecipitation assays, and binding assays using purified components. Which cell type is this shared protein par... | peripheral blood mononuclear cell | Medium | convergence | {"qa_id":"medium_convergence_03253","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARPC2 and AP2M1 both interact with a shared protein partner. Evidence indicates that the NTA region of this partner interacts directly with the Arp2/3 comple... | |
medium_convergence_03254 | Rhinovirus A and Human gammaherpesvirus 8 both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes shows a log2 fold change of approximately 1.71 and an adjusted p-value of 0.0494. Which protein is encoded by this gene? | Putative histone H2B type 2-D | Medium | convergence | {"qa_id":"medium_convergence_03254","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Human gammaherpesvirus 8 both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes shows a log2 fold chang... | |
medium_convergence_03255 | BLM and FAAP100 share multiple binding partners. One of these shared partners is reported to form a conserved DNA-remodeling complex with the histone-fold heterodimer MHF. Which gene does this specific shared partner interact with? | TELO2 | Medium | convergence | {"qa_id":"medium_convergence_03255","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BLM and FAAP100 share multiple binding partners. One of these shared partners is reported to form a conserved DNA-remodeling complex with the histone-fold he... | |
medium_convergence_03256 | Both Measles morbillivirus and Rhinovirus A are associated with the downregulation of a specific gene. Experimental data for this gene reports a log2 fold change of -1.080 and an adjusted p-value of 0.001632. Which protein is encoded by this gene? | Galactose mutarotase | Medium | convergence | {"qa_id":"medium_convergence_03256","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Rhinovirus A are associated with the downregulation of a specific gene. Experimental data for this gene reports a log2 fold ch... | |
medium_convergence_03257 | GRB2 and ARF6 share a common interaction partner. Evidence indicates that this shared partner is the adaptor protein for the Ras guanyl-nucleotide exchanger SOS, and it binds to Tyr1356 within the YVNV motif. Which protein is encoded by this shared interaction partner? | Hepatocyte growth factor receptor | Medium | convergence | {"qa_id":"medium_convergence_03257","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRB2 and ARF6 share a common interaction partner. Evidence indicates that this shared partner is the adaptor protein for the Ras guanyl-nucleotide exchanger ... | |
medium_convergence_03258 | FYN and GRB2 both interact with a specific protein. Evidence regarding this protein states: 'We have previously shown that GRB2 binds to P.Tyr789 in vivo and in vitro via its SH2 domain.' Which disease is associated with this protein as a biomarker? | colorectal carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03258","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FYN and GRB2 both interact with a specific protein. Evidence regarding this protein states: 'We have previously shown that GRB2 binds to P.Tyr789 in vivo and... | |
medium_convergence_03259 | DSP and FLG each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In extracts from HaCaT cells, distinct soluble complexes containing PKP1a and desmoplakin I (DPI) have been identified by co-immunoprecipitation and sucrose density fractionation.' Which protein is connected to ... | Plakophilin-1 | Medium | convergence | {"qa_id":"medium_convergence_03259","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DSP and FLG each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In extracts from HaCaT cells, distinct soluble c... | |
medium_convergence_03260 | TRIM28 and CDK9 share multiple interacting partners. One such shared partner has a physical interaction with KAP-1 that was experimentally verified by co-immunoprecipitation (Co-IP). Which disease is associated with this specific shared partner? | melanoma | Medium | convergence | {"qa_id":"medium_convergence_03260","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and CDK9 share multiple interacting partners. One such shared partner has a physical interaction with KAP-1 that was experimentally verified by co-imm... | |
medium_convergence_03261 | MAX and MYCN both interact with a shared protein. Evidence regarding one such shared partner states: 'The interaction between a shared partner and n-Myc was validated by pull-down experiments.' Which protein is encoded by the gene corresponding to this shared partner? | YEATS domain-containing protein 4 | Medium | convergence | {"qa_id":"medium_convergence_03261","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAX and MYCN both interact with a shared protein. Evidence regarding one such shared partner states: 'The interaction between a shared partner and n-Myc was ... | |
medium_convergence_03262 | ARCN1 and ARFGAP2 both interact with a shared protein. Evidence regarding this shared protein states: 'Using a photocrosslinking approach, we find that under native conditions a peptide analogous to the cytoplasmic domain of p23 interacts with coatomer exclusively through its gamma subunit and shares its binding site w... | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | Medium | convergence | {"qa_id":"medium_convergence_03262","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARCN1 and ARFGAP2 both interact with a shared protein. Evidence regarding this shared protein states: 'Using a photocrosslinking approach, we find that under... | |
medium_convergence_03264 | MIR221 and MIR448 are both involved in more than one shared biological process. Evidence indicates that overexpression of miR-448 promotes vascular smooth muscle cell (VSMC) migration. Which biological process, shared by both MIR221 and MIR448, positively regulates VSMC migration? | vascular associated smooth muscle cell migration | Medium | convergence | {"qa_id":"medium_convergence_03264","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MIR221 and MIR448 are both involved in more than one shared biological process. Evidence indicates that overexpression of miR-448 promotes vascular smooth mu... | |
medium_convergence_03265 | HUWE1 and CDKN2A both interact with a specific shared protein. Evidence regarding this shared protein states: 'Using a yeast two-hybrid screen, we identified human alternate reading frame (ARF) protein as a novel interaction partner of Miz-1.' Which protein is encoded by this shared entity? | Zinc finger and BTB domain-containing protein 17 | Medium | convergence | {"qa_id":"medium_convergence_03265","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HUWE1 and CDKN2A both interact with a specific shared protein. Evidence regarding this shared protein states: 'Using a yeast two-hybrid screen, we identified... | |
medium_convergence_03266 | FYN and CBL both interact with a specific shared protein. Evidence indicates that stem cell factor (SCF), the ligand for this shared protein, induces its interaction with CBL proteins and their subsequent mutual degradation. Which cellular component is this shared protein located in? | extracellular space | Medium | convergence | {"qa_id":"medium_convergence_03266","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FYN and CBL both interact with a specific shared protein. Evidence indicates that stem cell factor (SCF), the ligand for this shared protein, induces its int... | |
medium_convergence_03267 | Both Human gammaherpesvirus 4 and Human immunodeficiency virus 1 are known to downregulate a specific shared gene. In a study of gamma delta T-lymphocytes (GSE13906), this gene exhibited a log2 fold change of approximately -1.97 and an adjusted p-value of 0.026. Which cellular component is this gene located in? | focal adhesion | Medium | convergence | {"qa_id":"medium_convergence_03267","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human gammaherpesvirus 4 and Human immunodeficiency virus 1 are known to downregulate a specific shared gene. In a study of gamma delta T-lymphocytes (G... | |
medium_convergence_03268 | MSL1 and KAT8 both interact with a common protein partner. Structural evidence indicates that this partner forms an extended chain with MSL1, creating an extensive hydrophobic interface, whereas the interaction between MSL1 and MOF relies on electrostatic forces between the HAT domain and a long helix of MSL1. Which di... | Basilicata-Akhtar syndrome | Medium | convergence | {"qa_id":"medium_convergence_03268","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MSL1 and KAT8 both interact with a common protein partner. Structural evidence indicates that this partner forms an extended chain with MSL1, creating an ext... | |
medium_convergence_03269 | TXNIP and WWP1 share interaction partners. One shared partner heterodimerizes with another E3 ligase, WWP1, which specifically ubiquitinates and degrades ΔNp73. Which protein is encoded by this shared partner? | NEDD4-like E3 ubiquitin-protein ligase WWP2 | Medium | convergence | {"qa_id":"medium_convergence_03269","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TXNIP and WWP1 share interaction partners. One shared partner heterodimerizes with another E3 ligase, WWP1, which specifically ubiquitinates and degrades ΔNp... | |
medium_convergence_03270 | Glimepiride and Nateglinide share a common drug interaction partner. Evidence regarding this shared entity notes that while other MCT isoforms are less well characterized, ongoing studies indicate that MCT6 transports xenobiotics such as bumetanide, nateglinide, and this specific entity. Which disease is this entity in... | gout | Medium | convergence | {"qa_id":"medium_convergence_03270","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Glimepiride and Nateglinide share a common drug interaction partner. Evidence regarding this shared entity notes that while other MCT isoforms are less well ... | |
medium_convergence_03271 | Dengue virus and Enterovirus A both upregulate a specific gene. Evidence for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold change of approximately 1.756 and an adjusted p-value of 0.006557. Which biological process is this gene involved in? | recombinational repair | Medium | convergence | {"qa_id":"medium_convergence_03271","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Enterovirus A both upregulate a specific gene. Evidence for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold change o... | |
medium_convergence_03272 | CRK and BCAR1 each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'Furthermore, the association between p130(Cas) and the two zyxin family members was demonstrated to occur in vivo by co-immunoprecipitation.' Which protein is encoded by the gene corresponding to tha... | Thyroid receptor-interacting protein 6 | Medium | convergence | {"qa_id":"medium_convergence_03272","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRK and BCAR1 each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'Furthermore, the association between... | |
medium_convergence_03273 | SFN and HSP90AA1 share a common interaction partner. Evidence regarding this shared partner states: 'Furthermore, we identified the E3 ligase MYCBP2 and the heat shock proteins HSP90AA1/AB1 as interactors with the BTB domain that may result in the ubiquitination and subsequent degradation of intermediate filaments.' Wh... | Gigaxonin | Medium | convergence | {"qa_id":"medium_convergence_03273","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SFN and HSP90AA1 share a common interaction partner. Evidence regarding this shared partner states: 'Furthermore, we identified the E3 ligase MYCBP2 and the ... | |
medium_convergence_03274 | CLIP1 and CDC42 share a common binding partner. Evidence indicates that this shared entity is an effector of Rac1 and interacts with CLIP-170. Which protein is encoded by this shared entity? | Ras GTPase-activating-like protein IQGAP1 | Medium | convergence | {"qa_id":"medium_convergence_03274","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CLIP1 and CDC42 share a common binding partner. Evidence indicates that this shared entity is an effector of Rac1 and interacts with CLIP-170. Which protein ... | |
medium_convergence_03275 | OST4 and RPN2 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Co-immunoprecipitation studies suggest that OST4 associates with both STT3 isoforms and with ribophorin I, an accessory subunit of mammalian OSTs.' Which protein is encoded by that entity? | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A | Medium | convergence | {"qa_id":"medium_convergence_03275","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"OST4 and RPN2 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Co-immunoprecipitation studies suggest that OS... | |
medium_convergence_03276 | MYC and PTEN share a common interacting partner. Evidence indicates that CLK3 directly phosphorylates this shared entity at tyrosine 708, promoting its binding to c-Myc. This interaction prevents Fbxl14-mediated ubiquitination of c-Myc and activates the transcription of purine metabolic genes. Which protein is encoded ... | Ubiquitin carboxyl-terminal hydrolase 13 | Medium | convergence | {"qa_id":"medium_convergence_03276","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and PTEN share a common interacting partner. Evidence indicates that CLK3 directly phosphorylates this shared entity at tyrosine 708, promoting its bindi... | |
medium_convergence_03277 | Epirubicin and Quinine both interact with a specific drug. Evidence indicates that this drug enhances the cytotoxicity of epirubicin, doxorubicin, and actinomycin D in K562/VBL cells. Which disease is this drug indicated for? | schizophrenia | Medium | convergence | {"qa_id":"medium_convergence_03277","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Epirubicin and Quinine both interact with a specific drug. Evidence indicates that this drug enhances the cytotoxicity of epirubicin, doxorubicin, and actino... | |
medium_convergence_03278 | EHMT2 and CHD4 each interact with more than one shared protein partner. Evidence concerning one of these shared partners reports that in the ovary, this entity interacted with NuRD proteins (specifically the entity itself and HDAC1) and the core cohesin complex protein RAD21. Which protein is encoded by that entity? | Metastasis-associated protein MTA3 | Medium | convergence | {"qa_id":"medium_convergence_03278","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EHMT2 and CHD4 each interact with more than one shared protein partner. Evidence concerning one of these shared partners reports that in the ovary, this enti... | |
medium_convergence_03279 | PSME3 and ESR1 share multiple interacting partners. One such shared partner is reported to physically interact and functionally cooperate with ERα in breast cancer cells. Which protein is encoded by this specific shared partner? | NAD-dependent protein deacetylase sirtuin-1 | Medium | convergence | {"qa_id":"medium_convergence_03279","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PSME3 and ESR1 share multiple interacting partners. One such shared partner is reported to physically interact and functionally cooperate with ERα in breast ... | |
medium_convergence_03280 | ALYREF and CLP1 each interact with more than one shared protein partner. Evidence concerning one specific shared partner states: 'Both proteins interact with the mRNA export factor Aly and both are able to rescue the loss of Sub2p (the yeast homolog of UAP56), indicating that both proteins have similar functions.' Whic... | ATP-dependent RNA helicase DDX39A | Medium | convergence | {"qa_id":"medium_convergence_03280","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ALYREF and CLP1 each interact with more than one shared protein partner. Evidence concerning one specific shared partner states: 'Both proteins interact with... | |
medium_convergence_03281 | EZH2 and GRSF1 share a common interacting partner. Evidence indicates that this shared partner physically binds to EZH2, a component of the Polycomb repressive complex 2, which is required to repress CLU. Which protein is encoded by this shared interacting partner? | N-myc proto-oncogene protein | Medium | convergence | {"qa_id":"medium_convergence_03281","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EZH2 and GRSF1 share a common interacting partner. Evidence indicates that this shared partner physically binds to EZH2, a component of the Polycomb repressi... | |
medium_convergence_03283 | DVL2 and SMAD2 share a common binding partner. Experimental evidence indicates that this shared partner interacts with receptor-activated Smads (R-Smads), specifically Smad1, Smad2, and Smad3, but does not interact with Smad4. Which disease is associated with this shared binding partner? | lung adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_03283","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DVL2 and SMAD2 share a common binding partner. Experimental evidence indicates that this shared partner interacts with receptor-activated Smads (R-Smads), sp... | |
medium_convergence_03284 | STX1A and STX3 both interact with a shared protein partner. Evidence indicates that all full-length syntaxin isoforms form complexes with this partner and VAMP. Which cell type is enriched for this shared partner? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_03284","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STX1A and STX3 both interact with a shared protein partner. Evidence indicates that all full-length syntaxin isoforms form complexes with this partner and VA... | |
medium_convergence_03285 | PSMC4 and PAAF1 both interact with a shared protein partner. Evidence regarding this partner states: 'A yeast two-hybrid screen with the human S6 (TBP7, RPT3) ATPase of the 26 S proteasome has identified gankyrin, a liver oncoprotein, as an interacting protein.' Which protein is encoded by this shared partner? | 26S proteasome non-ATPase regulatory subunit 10 | Medium | convergence | {"qa_id":"medium_convergence_03285","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PSMC4 and PAAF1 both interact with a shared protein partner. Evidence regarding this partner states: 'A yeast two-hybrid screen with the human S6 (TBP7, RPT3... | |
medium_convergence_03286 | Dengue virus and Human gammaherpesvirus 8 both downregulate a specific gene. Experimental data from a hepatoma cell line study (GSE110512) indicates that for one such shared target, the log2 fold change is -2.975 and the adjusted p-value is 0.01757. Which disease is associated with this specific gene? | acute erythroid leukemia | Medium | convergence | {"qa_id":"medium_convergence_03286","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Human gammaherpesvirus 8 both downregulate a specific gene. Experimental data from a hepatoma cell line study (GSE110512) indicates that for... | |
medium_convergence_03287 | DSG1 and DSG2 both interact with a specific protein partner. Experimental evidence from overlay assays indicates that PP1 binds to DP, Dsc1a, and this partner (desmoglein 1), while PG binds to this partner and more weakly to Dsc1a and DP. Which protein is encoded by the gene corresponding to this partner? | Plakophilin-1 | Medium | convergence | {"qa_id":"medium_convergence_03287","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DSG1 and DSG2 both interact with a specific protein partner. Experimental evidence from overlay assays indicates that PP1 binds to DP, Dsc1a, and this partne... | |
medium_convergence_03288 | PARP1 and XPO7 share common interacting partners. One such partner is reported to form a complex with PARP-1, resulting in increased PARP-1 expression. Which protein is encoded by this specific interacting partner? | Ubiquitin carboxyl-terminal hydrolase 14 | Medium | convergence | {"qa_id":"medium_convergence_03288","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and XPO7 share common interacting partners. One such partner is reported to form a complex with PARP-1, resulting in increased PARP-1 expression. Which... | |
medium_convergence_03289 | Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for this gene, derived from a lung fibroblast cell line study (GSE120891), reports a log2 fold change of approximately 2.447 and an adjusted p-value of 0.03813. Which c... | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_03289","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for t... | |
medium_convergence_03290 | HDAC2 and MSH2 share a common interacting partner. Experimental evidence indicates that this shared partner, along with CHD4 and HDAC2, co-immunoprecipitates in endogenous conditions, and that the shared partner and HDAC2 co-elute through two biochemical purification steps. Which protein is encoded by this shared inter... | Serine/threonine-protein kinase ATR | Medium | convergence | {"qa_id":"medium_convergence_03290","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC2 and MSH2 share a common interacting partner. Experimental evidence indicates that this shared partner, along with CHD4 and HDAC2, co-immunoprecipitates... | |
medium_convergence_03291 | Both the androgen receptor (AR) and PIH1D1 interact with a common protein. Experimental evidence indicates that this shared protein interacts with AR in nuclear extracts from LNCaP cells in a ligand-independent manner. Which protein is encoded by the gene corresponding to this shared entity? | Protein UXT | Medium | convergence | {"qa_id":"medium_convergence_03291","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the androgen receptor (AR) and PIH1D1 interact with a common protein. Experimental evidence indicates that this shared protein interacts with AR in nucl... | |
medium_convergence_03293 | FKBP8 and MYC both interact with a specific proteasome subunit. Evidence indicates that FKBP38 directly interacts with the S4 subunit of the 19S proteasome. Which protein encodes the subunit identified by this evidence? | 26S proteasome regulatory subunit 6B | Medium | convergence | {"qa_id":"medium_convergence_03293","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FKBP8 and MYC both interact with a specific proteasome subunit. Evidence indicates that FKBP38 directly interacts with the S4 subunit of the 19S proteasome. ... | |
medium_convergence_03294 | BARD1 and BRCA1 both interact with a specific shared protein partner. Evidence indicates that this partner's COOH-terminal HECT-containing domain interacts with an NH(2)-terminal degron domain in BRCA1. Which disease is associated with this protein partner through genomic alterations? | T-cell prolymphocytic leukemia | Medium | convergence | {"qa_id":"medium_convergence_03294","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BARD1 and BRCA1 both interact with a specific shared protein partner. Evidence indicates that this partner's COOH-terminal HECT-containing domain interacts w... | |
medium_convergence_03295 | GSK3B and MDM2 share a common interaction partner. Evidence indicates that in the absence of Wnt signaling, the protein encoded by SNAI2 is phosphorylated by GSK3β and subsequently undergoes β-Trcp1-dependent ubiquitination and proteasomal degradation. Which protein is encoded by the gene corresponding to this shared i... | Zinc finger protein SNAI2 | Medium | convergence | {"qa_id":"medium_convergence_03295","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GSK3B and MDM2 share a common interaction partner. Evidence indicates that in the absence of Wnt signaling, the protein encoded by SNAI2 is phosphorylated by... | |
medium_convergence_03296 | Cyclosporine and Fluconazole both interact with a specific shared drug. Evidence regarding this shared drug highlights a potential for pharmacokinetic interactions, specifically noting a clinically relevant interaction with Cyclosporine that requires dose reduction. Which disease is this shared drug indicated for? | pulmonary arterial hypertension | Medium | convergence | {"qa_id":"medium_convergence_03296","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cyclosporine and Fluconazole both interact with a specific shared drug. Evidence regarding this shared drug highlights a potential for pharmacokinetic intera... | |
medium_convergence_03297 | FBXW11 and BTRC both interact with a shared protein target. Evidence regarding this target states: 'One central step controlling p100 processing consists in the interaction of the E3 ubiquitin ligase β-TrCP with p100, thereby leading to its ubiquitinylation and subsequent either complete degradation or partial proteoly... | Nuclear factor NF-kappa-B p100 subunit | Medium | convergence | {"qa_id":"medium_convergence_03297","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FBXW11 and BTRC both interact with a shared protein target. Evidence regarding this target states: 'One central step controlling p100 processing consists in ... | |
medium_convergence_03298 | KAT7 and BRD1 each interact with more than one shared protein. Evidence concerning one such shared entity states: 'Here, we demonstrate an interaction between CENP-A assembly factor [shared protein] and acetyltransferase KAT7/HBO1/MYST2.' Which protein is connected to that entity through the 'encodes' relationship? | Mis18-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_03298","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KAT7 and BRD1 each interact with more than one shared protein. Evidence concerning one such shared entity states: 'Here, we demonstrate an interaction betwee... | |
medium_convergence_03299 | SMAD3 and MDM2 share common interaction partners. One such shared partner is implicated in a study reporting that NICD and this partner interact directly, both in vitro and in cells, in a ligand-dependent manner. Which protein is encoded by this shared partner? | Neurogenic locus notch homolog protein 1 | Medium | convergence | {"qa_id":"medium_convergence_03299","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD3 and MDM2 share common interaction partners. One such shared partner is implicated in a study reporting that NICD and this partner interact directly, bo... | |
medium_convergence_03300 | Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line (study GSE120891) shows a log2 fold change of approximately 1.085 and an adjusted p-value of 0.0002964. What protein is encoded by this gene? | Interleukin-1 receptor-associated kinase-like 2 | Medium | convergence | {"qa_id":"medium_convergence_03300","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line (study GS... | |
medium_convergence_03302 | MED12L and ESR2 share interaction partners. One such shared partner is a component of the thyroid hormone receptor-associated protein (TRAP)/Mediator coactivator complex, which interacts with ERalpha and ERbeta in both unfractionated nuclear extracts and purified form. Which protein is encoded by this shared partner? | Mediator of RNA polymerase II transcription subunit 24 | Medium | convergence | {"qa_id":"medium_convergence_03302","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MED12L and ESR2 share interaction partners. One such shared partner is a component of the thyroid hormone receptor-associated protein (TRAP)/Mediator coactiv... | |
medium_convergence_03303 | GATA1 and H3C1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here, we demonstrate that the third PHD domain of [REDACTED] (PHD3) binds histone H3 trimethylated at lysine 4 (H3K4me3) with high affinity and specificity and H3K4me2 with 8-fold lower affinity.' Which prote... | Histone-lysine N-methyltransferase 2A | Medium | convergence | {"qa_id":"medium_convergence_03303","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GATA1 and H3C1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here, we demonstrate that the third PHD domai... | |
medium_convergence_03304 | MDM2 and MYC both interact with a specific shared gene product. Evidence regarding this shared entity states: 'Immunoprecipitation analyses showed that hTERT and Hdm2 bound to each other in multiple domains.' Which protein is encoded by this shared gene? | Telomerase reverse transcriptase | Medium | convergence | {"qa_id":"medium_convergence_03304","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MDM2 and MYC both interact with a specific shared gene product. Evidence regarding this shared entity states: 'Immunoprecipitation analyses showed that hTERT... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.