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medium_convergence_03305 | CUL4A and CHD1L both interact with a shared protein. Evidence indicates that this shared protein forms a heterodimer with DDB1 to constitute the UV-DDB complex, which functions as a component of the CUL4A-based ubiquitin ligase. Which cell type is this shared protein enriched in? | regulatory T cell | Medium | convergence | {"qa_id":"medium_convergence_03305","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CUL4A and CHD1L both interact with a shared protein. Evidence indicates that this shared protein forms a heterodimer with DDB1 to constitute the UV-DDB compl... | |
medium_convergence_03306 | SIN3A and GFI1 both interact with a shared protein entity. Experimental evidence regarding a mutant of this entity indicates that it retains the ability to homodimerize and bind to N-CoR, but exhibits only weak binding to mSin3A. Which protein is encoded by this shared entity? | Protein CBFA2T1 | Medium | convergence | {"qa_id":"medium_convergence_03306","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIN3A and GFI1 both interact with a shared protein entity. Experimental evidence regarding a mutant of this entity indicates that it retains the ability to h... | |
medium_convergence_03307 | CREBBP and HLTF each interact with more than one shared gene product. Evidence concerning one shared entity reports that transfected and endogenous human Pygopus2 and CBP proteins co-immunoprecipitate in HEK-293 cells and both proteins co-localize in SW480 colorectal cancer cells. Which cellular component is connected ... | beta-catenin-TCF complex | Medium | convergence | {"qa_id":"medium_convergence_03307","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and HLTF each interact with more than one shared gene product. Evidence concerning one shared entity reports that transfected and endogenous human Pyg... | |
medium_convergence_03308 | Vaccinia virus and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately 4.602 and an adjusted p-value of 0.02879. Which protein does this gene product interact with? | FKBP7 | Medium | convergence | {"qa_id":"medium_convergence_03308","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) rep... | |
medium_convergence_03309 | RHOA and RHOC both interact with a common downstream effector. Evidence indicates that when transamidated, RHOA functions as a constitutively active G-protein and exhibits increased binding to this specific effector, which is identified as RhoA-associated kinase-2 (ROCK-2). Which protein is encoded by the gene correspo... | Rho-associated protein kinase 2 | Medium | convergence | {"qa_id":"medium_convergence_03309","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RHOA and RHOC both interact with a common downstream effector. Evidence indicates that when transamidated, RHOA functions as a constitutively active G-protei... | |
medium_convergence_03310 | ERBB3 and NPM1 share a common interacting partner. Evidence indicates that this shared partner is a 47 kDa ubiquitously expressed protein that binds the ERBB3 receptor in human serum-starved breast cancer cell lines and dissociates upon treatment with the ligand Heregulin (HRG). Which protein is encoded by the gene cor... | Proliferation-associated protein 2G4 | Medium | convergence | {"qa_id":"medium_convergence_03310","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB3 and NPM1 share a common interacting partner. Evidence indicates that this shared partner is a 47 kDa ubiquitously expressed protein that binds the ERBB... | |
medium_convergence_03311 | Rhinovirus A and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) shows a log2 fold change of approximately 1.154 and an adjusted p-value of 0.02671. Which disease is associated with this gene through genomic alterations? | dementia | Medium | convergence | {"qa_id":"medium_convergence_03311","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) shows a ... | |
medium_convergence_03312 | MDC1 and KDM4A share multiple protein interaction partners. One such shared partner is distinguished by evidence describing an interaction between its BRCT domain and phosphorylated Ser 102 of a histone methyltransferase. Which protein is encoded by this shared partner? | Histone-lysine N-methyltransferase NSD2 | Medium | convergence | {"qa_id":"medium_convergence_03312","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MDC1 and KDM4A share multiple protein interaction partners. One such shared partner is distinguished by evidence describing an interaction between its BRCT d... | |
medium_convergence_03313 | Both Human immunodeficiency virus 1 and Dengue virus are reported to downregulate a specific gene. Experimental data for this gene in macrophages (from study GSE108897) shows a log2 fold change of -3.432 and an adjusted p-value of 0.0001161. Which protein is encoded by this gene? | Leiomodin-1 | Medium | convergence | {"qa_id":"medium_convergence_03313","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus are reported to downregulate a specific gene. Experimental data for this gene in macrophages (from study... | |
medium_convergence_03314 | Both Measles morbillivirus and Cardiovirus A are associated with the downregulation of a specific gene. Experimental data for this gene from study GSE131840 indicates a log2 fold change of -1.043 and an adjusted p-value of 0.0001433. Which protein is encoded by this gene? | Cytochrome c | Medium | convergence | {"qa_id":"medium_convergence_03314","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Cardiovirus A are associated with the downregulation of a specific gene. Experimental data for this gene from study GSE131840 ... | |
medium_convergence_03315 | PABPC1 and PRKN (also known as PARK2) share multiple interacting partners. One such shared partner is supported by evidence stating: 'For PABP1 and eIF4b the interactions were confirmed in the context of the corresponding full-length proteins in cellular lysates.' Which protein is encoded by the gene corresponding to t... | Tumor susceptibility gene 101 protein | Medium | convergence | {"qa_id":"medium_convergence_03315","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PABPC1 and PRKN (also known as PARK2) share multiple interacting partners. One such shared partner is supported by evidence stating: 'For PABP1 and eIF4b the... | |
medium_convergence_03316 | H3C1 and HDAC9 each share a binding partner with a specific transcriptional co-repressor. Evidence indicates that this shared entity interacts and co-localizes in vivo with transcriptional repressors including TEL and a corepressor implicated in hematological malignancies, and its function is implicated in the pathogen... | Nuclear receptor corepressor 1 | Medium | convergence | {"qa_id":"medium_convergence_03316","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"H3C1 and HDAC9 each share a binding partner with a specific transcriptional co-repressor. Evidence indicates that this shared entity interacts and co-localiz... | |
medium_convergence_03317 | AGO4 and MOV10 both interact with a shared protein partner. Evidence indicates that the N-terminal GW-repeat-containing regions of all three TNRC6 proteins interact with the four human Argonaute proteins, including AGO4. Which cell type is enriched for this shared protein partner? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_03317","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AGO4 and MOV10 both interact with a shared protein partner. Evidence indicates that the N-terminal GW-repeat-containing regions of all three TNRC6 proteins i... | |
medium_convergence_03318 | AIF1 and CXCL10 are both associated with more than one shared biological process. One piece of evidence states that AIF-1-transduced vascular smooth muscle cells (VSMCs) are chemotactic for human monocytes. Which biological process, linked to the entity described in this evidence, is defined by the relation 'positively... | monocyte chemotaxis | Medium | convergence | {"qa_id":"medium_convergence_03318","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AIF1 and CXCL10 are both associated with more than one shared biological process. One piece of evidence states that AIF-1-transduced vascular smooth muscle c... | |
medium_convergence_03319 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately -1.79 and an adjusted p-value of 0.0113. Which protein is encoded by this gene? | Collagen alpha-2(I) chain | Medium | convergence | {"qa_id":"medium_convergence_03319","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (st... | |
medium_convergence_03320 | Vaccinia virus and Enterovirus A both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) shows a log2 fold change of approximately -1.034 and an adjusted p-value of 0.03051. Which protein is encoded by this gene? | Kelch-like protein 5 | Medium | convergence | {"qa_id":"medium_convergence_03320","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Enterovirus A both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) s... | |
medium_convergence_03321 | Both NTF3 and BDNF interact with a common receptor protein. Evidence indicates that the extracellular domain of the human neurotrophin receptor corresponding to the gene NTRK2, when expressed in Chinese hamster ovary cells, is a highly glycosylated protein capable of binding brain-derived neurotrophic factor. Which pro... | BDNF/NT-3 growth factors receptor | Medium | convergence | {"qa_id":"medium_convergence_03321","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both NTF3 and BDNF interact with a common receptor protein. Evidence indicates that the extracellular domain of the human neurotrophin receptor corresponding... | |
medium_convergence_03322 | SAP30BP and SAP130 both interact with a common protein partner. Evidence regarding this shared partner indicates that it possesses a repression domain at its C-terminus that interacts with the mSin3A-HDAC complex, and an N-terminal domain that likely mediates interaction with a transcriptional activator. Which protein ... | Paired amphipathic helix protein Sin3a | Medium | convergence | {"qa_id":"medium_convergence_03322","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SAP30BP and SAP130 both interact with a common protein partner. Evidence regarding this shared partner indicates that it possesses a repression domain at its... | |
medium_convergence_03323 | RACK1 and PAN3 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'We found that human GW182 proteins recruit the PAN2-PAN3 and CCR4-CAF1-NOT deadenylase complexes through direct interactions with PAN3 and NOT1, respectively.' Which protein is encoded by that entity? | Trinucleotide repeat-containing gene 6C protein | Medium | convergence | {"qa_id":"medium_convergence_03323","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RACK1 and PAN3 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'We found that human GW182 proteins recru... | |
medium_convergence_03324 | FANCE and CENPS each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here we associate the FA proteins with the Notch1 developmental pathway through a direct protein-protein interaction between the FA core complex and the hairy enhancer of split 1.' Which protein is connected... | Transcription factor HES-1 | Medium | convergence | {"qa_id":"medium_convergence_03324","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCE and CENPS each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here we associate the FA proteins with the N... | |
medium_convergence_03325 | CDC37 and CTNND1 both interact with a specific shared protein. Evidence indicates that delta-catenin interacts with this shared protein in a tyrosine phosphorylation-dependent manner. Which protein is encoded by this shared entity? | Src substrate cortactin | Medium | convergence | {"qa_id":"medium_convergence_03325","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC37 and CTNND1 both interact with a specific shared protein. Evidence indicates that delta-catenin interacts with this shared protein in a tyrosine phospho... | |
medium_convergence_03326 | CDC45 and CDC6 both interact with a shared protein partner. Evidence indicates that this specific partner binds strongly to ORC1 and to MCM7 proteins. Which disease is associated with this shared protein partner? | Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome | Medium | convergence | {"qa_id":"medium_convergence_03326","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC45 and CDC6 both interact with a shared protein partner. Evidence indicates that this specific partner binds strongly to ORC1 and to MCM7 proteins. Which ... | |
medium_convergence_03327 | NBN and RAD1 share multiple protein interaction partners. One shared partner is characterized by evidence stating that mutations in the nibrin FHA and BRCT domains did not affect its interaction with Mre11 or the nuclear localization of the complex. Which protein is encoded by the gene corresponding to this shared part... | DNA repair protein RAD50 | Medium | convergence | {"qa_id":"medium_convergence_03327","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NBN and RAD1 share multiple protein interaction partners. One shared partner is characterized by evidence stating that mutations in the nibrin FHA and BRCT d... | |
medium_convergence_03329 | ERCC6 and PCNA share common interacting partners. One such partner is identified in evidence stating: 'Using a yeast two-hybrid approach, we identified the 5'-3' exonuclease SNM1A as one of four strong interacting partners of CSB.' Which protein is encoded by the gene corresponding to this shared interacting partner? | DNA cross-link repair 1A protein | Medium | convergence | {"qa_id":"medium_convergence_03329","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERCC6 and PCNA share common interacting partners. One such partner is identified in evidence stating: 'Using a yeast two-hybrid approach, we identified the 5... | |
medium_convergence_03330 | ANAPC4 and CCNE2 each interact with more than one shared protein. Evidence concerning one shared entity reports that Cyclin E2 associates with this kinase in a functional complex that is inhibited by both p27(Kip1) and p21(Cip1). Which cell type is connected to that entity through the 'enriched in' relationship? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_03330","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC4 and CCNE2 each interact with more than one shared protein. Evidence concerning one shared entity reports that Cyclin E2 associates with this kinase in... | |
medium_convergence_03331 | DVL2 and DVL3 both interact with a specific shared protein. Evidence indicates that the physical interaction with DVL is essential for the Wnt inhibitory activity of ZNRF3 and this shared protein. Which protein is encoded by the gene corresponding to this shared entity? | E3 ubiquitin-protein ligase RNF43 | Medium | convergence | {"qa_id":"medium_convergence_03331","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DVL2 and DVL3 both interact with a specific shared protein. Evidence indicates that the physical interaction with DVL is essential for the Wnt inhibitory act... | |
medium_convergence_03332 | KLHDC2 and PPARG both interact with a specific selenoprotein. Research reports three crystal structures of a CRL2 substrate receptor, identified as this shared entity, in complex with the diglycine-ending C-end degrons of two early-terminated selenoproteins and the N-terminal proteolytic fragment of USP1. Which cell ty... | basophil | Medium | convergence | {"qa_id":"medium_convergence_03332","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KLHDC2 and PPARG both interact with a specific selenoprotein. Research reports three crystal structures of a CRL2 substrate receptor, identified as this shar... | |
medium_convergence_03333 | MCM6 and ORC2 both interact with a common protein partner. Experimental evidence regarding this shared partner describes the following binary interactions: HsOrc2-HsOrc3, HsOrc2-HsOrc4, HsOrc3-HsOrc4, HsOrc2-HsOrc6, and HsOrc3-HsOrc6. Which protein is encoded by the gene corresponding to this shared partner? | Origin recognition complex subunit 6 | Medium | convergence | {"qa_id":"medium_convergence_03333","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MCM6 and ORC2 both interact with a common protein partner. Experimental evidence regarding this shared partner describes the following binary interactions: H... | |
medium_convergence_03334 | FANCA and CENPS both interact with a shared protein. Evidence regarding this shared protein states: 'The N terminus appears to stabilize the interaction with FANCA and FANCG and is essential for the binding of the FANCC/FANCE subcomplex.' Which disease is associated with this protein through genomic alterations? | Fanconi anemia | Medium | convergence | {"qa_id":"medium_convergence_03334","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCA and CENPS both interact with a shared protein. Evidence regarding this shared protein states: 'The N terminus appears to stabilize the interaction with... | |
medium_convergence_03335 | GEMIN5 and GEMIN8 both interact with a specific shared protein. Evidence indicates that this shared protein binds directly to SMN and functions as a component of the SMN complex. Which protein is encoded by the gene corresponding to this shared entity? | Survival motor neuron protein | Medium | convergence | {"qa_id":"medium_convergence_03335","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GEMIN5 and GEMIN8 both interact with a specific shared protein. Evidence indicates that this shared protein binds directly to SMN and functions as a componen... | |
medium_convergence_03336 | CCL4L1 and CCL5 both interact with a specific protein. Experimental evidence indicates that RANTES (CCL5) associates with this protein, along with CCR1, syndecan-1, syndecan-4, CD44, and its GPCRs, but does not associate with syndecan-2 or betaglycan. Which protein is encoded by the gene corresponding to this interacti... | C-C chemokine receptor type 5 | Medium | convergence | {"qa_id":"medium_convergence_03336","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCL4L1 and CCL5 both interact with a specific protein. Experimental evidence indicates that RANTES (CCL5) associates with this protein, along with CCR1, synd... | |
medium_convergence_03337 | Both Human immunodeficiency virus 1 and Orthohepevirus A are known to downregulate a specific gene. In a study of macrophages (GSE108897), evidence for one such shared target reports a log2 fold change of -3.716 and an adjusted p-value of 0.000539. Which protein is encoded by this gene? | Nuclear receptor subfamily 4immunitygroup A member 1 | Medium | convergence | {"qa_id":"medium_convergence_03337","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Orthohepevirus A are known to downregulate a specific gene. In a study of macrophages (GSE108897), evidence for one s... | |
medium_convergence_03338 | ESR1 and UBE2K share a common interacting partner. Evidence indicates that this shared partner, along with CLIM, was identified as a novel ERalpha cofactor that colocalizes and interacts with ERalpha in primary human breast tumors. Which protein is encoded by this shared interacting partner? | E3 ubiquitin-protein ligase RLIM | Medium | convergence | {"qa_id":"medium_convergence_03338","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and UBE2K share a common interacting partner. Evidence indicates that this shared partner, along with CLIM, was identified as a novel ERalpha cofactor t... | |
medium_convergence_03339 | Human betaherpesvirus 5 and Dengue virus both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (study GSE111036) reports a log2 fold change of approximately -1.58 and an adjusted p-value of approximately 0.041. Which protein is encoded by this gene? | Glutathione S-transferase LANCL1 | Medium | convergence | {"qa_id":"medium_convergence_03339","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Dengue virus both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (study GSE11103... | |
medium_convergence_03340 | CDK7 and EAF2 both interact with a shared protein partner. Experimental evidence for one such partner states: 'Using specific antibodies generated to EAF2, we coimmunoprecipitated [the partner] and EAF2 from multiple cell lines.' Which protein product is encoded by this shared partner? | RNA polymerase II elongation factor ELL | Medium | convergence | {"qa_id":"medium_convergence_03340","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK7 and EAF2 both interact with a shared protein partner. Experimental evidence for one such partner states: 'Using specific antibodies generated to EAF2, w... | |
medium_convergence_03341 | MED12L and THRA share common interaction partners. One such shared partner is supported by evidence stating: 'In mammalian two-hybrid experiments as well as in GST-pull down assays, hSrb7 interacts with TR but not with other nuclear receptors such as the retinoic acid receptor (RAR) or the vitamin D receptor (VDR).' Wh... | Mediator of RNA polymerase II transcription subunit 21 | Medium | convergence | {"qa_id":"medium_convergence_03341","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MED12L and THRA share common interaction partners. One such shared partner is supported by evidence stating: 'In mammalian two-hybrid experiments as well as ... | |
medium_convergence_03342 | Both the thoracic vertebra endochondral element and the sacral vertebra endochondral element share a common anatomical superclass. Evidence regarding one of these shared entities describes it as 'A vertebral endochondral element in the thoracic region of the vertebral column.' Which anatomical entity is the superclass ... | skeletal element | Medium | convergence | {"qa_id":"medium_convergence_03342","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the thoracic vertebra endochondral element and the sacral vertebra endochondral element share a common anatomical superclass. Evidence regarding one of ... | |
medium_convergence_03343 | EWSR1 and MAP3K7 both interact with a shared protein. Evidence indicates that in response to a high-fat diet, this protein binds to TGF-β-activated kinase 1 (TAK1) in hepatocytes to induce TAK1 ubiquitination and subsequent autophosphorylation. This process enhances the activation of downstream IKKβ-NF-κB and MKK-JNK-I... | TNF receptor-associated factor 3 | Medium | convergence | {"qa_id":"medium_convergence_03343","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EWSR1 and MAP3K7 both interact with a shared protein. Evidence indicates that in response to a high-fat diet, this protein binds to TGF-β-activated kinase 1 ... | |
medium_convergence_03344 | Both Human immunodeficiency virus 1 and Zaire ebolavirus are known to downregulate the expression of a specific gene. In a study of macrophages (GSE108897), one such shared target gene exhibited a log2 fold change of -6.445 and an adjusted p-value of 0.008545. What is the name of the protein encoded by this gene? | C-X-C chemokine receptor type 4 | Medium | convergence | {"qa_id":"medium_convergence_03344","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Zaire ebolavirus are known to downregulate the expression of a specific gene. In a study of macrophages (GSE108897), ... | |
medium_convergence_03345 | Hepacivirus C and Dengue virus both downregulate a specific gene. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE119117) shows a log2 fold change of approximately -1.48 and an adjusted p-value of approximately 0.015. Which protein is encoded by this gene? | Mediator of RNA polymerase II transcription subunit 20 | Medium | convergence | {"qa_id":"medium_convergence_03345","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Dengue virus both downregulate a specific gene. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE119117... | |
medium_convergence_03346 | STUB1 and CCT4 both interact with a specific shared protein. Evidence regarding this shared entity indicates that CHIP is a cytosolic U-box protein that interacts with Hsc70 through a set of tetratricopeptide motifs. Which protein is encoded by this shared entity? | Cystic fibrosis transmembrane conductance regulator | Medium | convergence | {"qa_id":"medium_convergence_03346","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and CCT4 both interact with a specific shared protein. Evidence regarding this shared entity indicates that CHIP is a cytosolic U-box protein that inte... | |
medium_convergence_03347 | FANCA and CENPS each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'In normal cells, HA-tagged [protein] coimmunoprecipitates with FANCA, FANCC, and FANCG but not with FANCD2.' Which protein is encoded by the gene corresponding to this shared partner? | Fanconi anemia group E protein | Medium | convergence | {"qa_id":"medium_convergence_03347","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCA and CENPS each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'In normal cells, HA-tagged [pro... | |
medium_convergence_03348 | TRIM28 and SUB1 both interact with a shared protein. Experimental evidence confirms that the interactions of this shared protein with TRIM28 were validated using co-immunoprecipitation and immunocytochemistry. Which protein is encoded by this shared entity? | RE1-silencing transcription factor | Medium | convergence | {"qa_id":"medium_convergence_03348","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and SUB1 both interact with a shared protein. Experimental evidence confirms that the interactions of this shared protein with TRIM28 were validated u... | |
medium_convergence_03349 | HSPA8 and IPO5 both interact with a specific shared protein. Evidence indicates that Karyopherin beta3 contains two putative binding homology regions for this protein and binds to its GTP-bound form with significantly higher affinity than to its GDP-bound form in solution-binding assays. Which protein is encoded by thi... | GTP-binding nuclear protein Ran | Medium | convergence | {"qa_id":"medium_convergence_03349","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA8 and IPO5 both interact with a specific shared protein. Evidence indicates that Karyopherin beta3 contains two putative binding homology regions for thi... | |
medium_convergence_03350 | HSPA5 and HSPA8 both interact with a shared protein partner. Evidence indicates that GRP78 is a partner of this specific entity in all phases of adipogenesis. Which protein is encoded by this shared partner? | BTB/POZ domain-containing protein KCTD15 | Medium | convergence | {"qa_id":"medium_convergence_03350","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA5 and HSPA8 both interact with a shared protein partner. Evidence indicates that GRP78 is a partner of this specific entity in all phases of adipogenesis... | |
medium_convergence_03351 | HNRNPA1 and AR both interact with a shared protein. Evidence indicates that for one such shared entity, this protein enhances the DNA-binding activity of its variant AR-V7 through direct interaction and inhibits CHIP E3 ligase-mediated ubiquitination and degradation of AR-V7 by competing with CHIP for binding, thereby ... | Cell cycle and apoptosis regulator protein 2 | Medium | convergence | {"qa_id":"medium_convergence_03351","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HNRNPA1 and AR both interact with a shared protein. Evidence indicates that for one such shared entity, this protein enhances the DNA-binding activity of its... | |
medium_convergence_03352 | Both AHR and JUN interact with a shared protein entity. Experimental evidence regarding this entity describes a major interaction mapped to the silencing domain of a nuclear receptor corepressor and the PAS B ligand binding domain of the entity, noting that this interaction is unaffected by the addition of the entity's... | Nuclear receptor corepressor 2 | Medium | convergence | {"qa_id":"medium_convergence_03352","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both AHR and JUN interact with a shared protein entity. Experimental evidence regarding this entity describes a major interaction mapped to the silencing dom... | |
medium_convergence_03353 | Both mmu-let-7f-5p and mmu-miR-20a-5p regulate a specific type of T cell. A study using a mouse model describes a dual role for let-7 microRNAs in regulating CD8 T cell responses, noting that while high let-7 expression maintains the naive phenotype, the generation of cytotoxic T lymphocytes depends on T cell receptor-... | effector T cell | Medium | convergence | {"qa_id":"medium_convergence_03353","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both mmu-let-7f-5p and mmu-miR-20a-5p regulate a specific type of T cell. A study using a mouse model describes a dual role for let-7 microRNAs in regulating... | |
medium_convergence_03354 | Both IL17RA and TSLP are involved in multiple shared biological processes. One of these shared processes is characterized by evidence stating: 'Like IL-25, this activity is dependent on the IL-17RA and IL-17RB receptor subunits.' Which biological process, connected to this specific entity via the relation 'positively r... | interleukin-13 production | Medium | convergence | {"qa_id":"medium_convergence_03354","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both IL17RA and TSLP are involved in multiple shared biological processes. One of these shared processes is characterized by evidence stating: 'Like IL-25, t... | |
medium_convergence_03355 | CDK4 and ID2 share multiple interacting partners. One such partner is described in the following evidence: 'Here we show that [the protein encoded by MYOD1] can interact with cyclin-dependent kinase 4 through a conserved 15 amino acid (aa) domain in the C-terminus of [the protein encoded by MYOD1].' Which protein is en... | Myoblast determination protein 1 | Medium | convergence | {"qa_id":"medium_convergence_03355","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK4 and ID2 share multiple interacting partners. One such partner is described in the following evidence: 'Here we show that [the protein encoded by MYOD1] ... | |
medium_convergence_03357 | TRIM28 and YWHAQ share a common interaction partner. Evidence indicates that this shared partner interacts with TRIM28, described as a master regulator of gene expression, within the nucleus of NSCLC cells. Which disease is associated with this shared partner via a biomarker relationship? | squamous cell carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03357","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and YWHAQ share a common interaction partner. Evidence indicates that this shared partner interacts with TRIM28, described as a master regulator of ge... | |
medium_convergence_03358 | ITGB3BP and IKBKB each interact with more than one shared gene product. Evidence concerning one shared entity reports that Aβ significantly reduced NF-κB activity by attenuating the interaction of p75(NTR) with IKKβ. Which protein is encoded by that entity? | Tumor necrosis factor receptor superfamily member 16 | Medium | convergence | {"qa_id":"medium_convergence_03358","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ITGB3BP and IKBKB each interact with more than one shared gene product. Evidence concerning one shared entity reports that Aβ significantly reduced NF-κB act... | |
medium_convergence_03360 | GNG4 and ARRB2 both interact with a shared protein. Experimental evidence indicates that the carboxyl terminus and the third intracellular loop of the delta opioid receptor (DOR) are sufficient for binding to beta-arrestin 1 and 2. Which disease is associated with this shared protein via a biomarker relationship? | gastric carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03360","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNG4 and ARRB2 both interact with a shared protein. Experimental evidence indicates that the carboxyl terminus and the third intracellular loop of the delta ... | |
medium_convergence_03361 | LEF1 and ACTL6A each interact with more than one shared gene. Evidence concerning one shared entity reports: 'Here we show the interaction between the basic helix-loop-helix and leucine-zipper region of a transcription factor and LEF-1.' Which disease is connected to that entity through a causal relationship? | megacolon | Medium | convergence | {"qa_id":"medium_convergence_03361","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LEF1 and ACTL6A each interact with more than one shared gene. Evidence concerning one shared entity reports: 'Here we show the interaction between the basic ... | |
medium_convergence_03362 | Both ADRA2B and EGFR interact with a specific shared protein. Experimental evidence indicates that this shared protein physically interacts with the alpha-2B adrenergic receptor (alpha2B-AR). Specifically, the interaction involves the triple Arg motif in the third intracellular loop of the receptor and the acidic motif... | ADP-ribosylation factor-binding protein GGA3 | Medium | convergence | {"qa_id":"medium_convergence_03362","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both ADRA2B and EGFR interact with a specific shared protein. Experimental evidence indicates that this shared protein physically interacts with the alpha-2B... | |
medium_convergence_03363 | RANBP9 and TRIM28 both interact with a specific shared protein. Evidence indicates that the interaction between KAP-1 and this shared protein was verified by co-immunoprecipitation (Co-IP). Which protein is encoded by this shared entity? | Probable ATP-dependent RNA helicase DDX5 | Medium | convergence | {"qa_id":"medium_convergence_03363","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RANBP9 and TRIM28 both interact with a specific shared protein. Evidence indicates that the interaction between KAP-1 and this shared protein was verified by... | |
medium_convergence_03364 | In a study of bronchial epithelial cells (GSE147507), both Influenza A virus and Cardiovirus A were found to upregulate a specific gene. Evidence for this gene reports a log2 fold change of approximately 1.145 and an adjusted p-value of 0.0003454. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_03364","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"In a study of bronchial epithelial cells (GSE147507), both Influenza A virus and Cardiovirus A were found to upregulate a specific gene. Evidence for this ge... | |
medium_convergence_03365 | CCT7 and PRKN share multiple interacting partners. One such shared partner is described in the following evidence: 'Here, we demonstrate that Parkin interacts with, ubiquitylates and promotes the degradation of [the shared partner], a key structural component of the mammalian aminoacyl-tRNA synthetase complex.' Which c... | conventional dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_03365","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCT7 and PRKN share multiple interacting partners. One such shared partner is described in the following evidence: 'Here, we demonstrate that Parkin interact... | |
medium_convergence_03366 | Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. In a study using a cervical adenocarcinoma cell line (GSE11238), this gene exhibited a log2 fold change of approximately -2.1 and an adjusted p-value of approximately 0.047. Which biological process is this gene involved in? | unsaturated fatty acid biosynthetic process | Medium | convergence | {"qa_id":"medium_convergence_03366","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. In a study using a cervical adenocarcinoma cell line (GSE11238), this gene exhi... | |
medium_convergence_03367 | C2CD3 and CDK1 both interact with a specific centrosomal protein. Evidence indicates that this protein binds to and recruits CDK1 to centrosomes, thereby regulating mitotic entry. Which protein is encoded by the gene corresponding to this interacting partner? | Centrosomal protein of 63 kDa | Medium | convergence | {"qa_id":"medium_convergence_03367","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"C2CD3 and CDK1 both interact with a specific centrosomal protein. Evidence indicates that this protein binds to and recruits CDK1 to centrosomes, thereby reg... | |
medium_convergence_03368 | Both INHA and INHBA interact with multiple shared receptors. One such shared receptor is discussed in the context of the hypothesis: 'We hypothesized that, in addition to its canonical receptor [REDACTED], activin A might similarly bind and signal via BMPR2.' Which protein is encoded by this specific shared receptor? | Activin receptor type-2A | Medium | convergence | {"qa_id":"medium_convergence_03368","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both INHA and INHBA interact with multiple shared receptors. One such shared receptor is discussed in the context of the hypothesis: 'We hypothesized that, i... | |
medium_convergence_03369 | COPS4 and COPS3 each interact with more than one shared protein. Evidence concerning one shared entity reports that TA binds CSN4 and the synaptic regulator snapin in neuroblastoma cells and in brain synaptosomes. Which protein is connected to that entity through the 'encodes' relationship? | Torsin-1A | Medium | convergence | {"qa_id":"medium_convergence_03369","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS4 and COPS3 each interact with more than one shared protein. Evidence concerning one shared entity reports that TA binds CSN4 and the synaptic regulator ... | |
medium_convergence_03370 | HIPK2 and NFIX share common interaction partners. One such shared partner is described as interacting with transcription factors, including homeoproteins, and regulating their activities. Which protein is encoded by this specific shared partner? | Paired box protein Pax-6 | Medium | convergence | {"qa_id":"medium_convergence_03370","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HIPK2 and NFIX share common interaction partners. One such shared partner is described as interacting with transcription factors, including homeoproteins, an... | |
medium_convergence_03371 | PDHB and UQCRC1 each interact with more than one shared protein. Evidence concerning one such shared entity reports: 'Furthermore, yeast two-hybrid interaction studies demonstrated the interaction of MuRF1 with PDH, PDK2, PDK4, PKM2 (all participating in glycolysis) and with phosphorylase beta (PYGM) and glycogenin (bo... | E3 ubiquitin-protein ligase TRIM63 | Medium | convergence | {"qa_id":"medium_convergence_03371","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PDHB and UQCRC1 each interact with more than one shared protein. Evidence concerning one such shared entity reports: 'Furthermore, yeast two-hybrid interacti... | |
medium_convergence_03372 | MYC and TP53 both interact with a shared protein. Evidence regarding this protein states: 'We further show that a cervical cancer-derived mutant of this protein has less p53 binding ability and lacks a proliferation-repressive function.' Which disease is associated with this protein through genomic alterations? | glioblastoma | Medium | convergence | {"qa_id":"medium_convergence_03372","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and TP53 both interact with a shared protein. Evidence regarding this protein states: 'We further show that a cervical cancer-derived mutant of this prot... | |
medium_convergence_03373 | HCFC1 and KANSL2 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'We also find that [the protein encoded by the shared partner] is a component of additional complexes, forming associations with host cell factor 1 and a protein distantly related to MSL1 (hMSL1... | Histone acetyltransferase KAT8 | Medium | convergence | {"qa_id":"medium_convergence_03373","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HCFC1 and KANSL2 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'We also find that [the protein... | |
medium_convergence_03374 | Both Measles morbillivirus and Influenza A virus are associated with the downregulation of a specific gene. Experimental data for this gene from study GSE131840 indicates a log2 fold change of approximately -1.059 and an adjusted p-value of 0.003486. What protein is encoded by this gene? | 5-hydroxymethyl-dUMP N-hydrolase | Medium | convergence | {"qa_id":"medium_convergence_03374","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Influenza A virus are associated with the downregulation of a specific gene. Experimental data for this gene from study GSE131... | |
medium_convergence_03375 | H3-3A and H3C1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Using an unbiased in vitro biochemical approach, we have identified a transcription and cell cycle regulator, as a novel methyl K9 H3-specific binding protein.' Which disease is connected to that entity throu... | gastric cancer | Medium | convergence | {"qa_id":"medium_convergence_03375","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"H3-3A and H3C1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Using an unbiased in vitro biochemical approa... | |
medium_convergence_03376 | CHMP6 and MVB12A each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Double and triple immunofluorescence, proximity ligation immunofluorescence and co-immuoprecipitation studies revealed the association of this entity with the KSHV containing macropinosomes, and increased l... | Tumor susceptibility gene 101 protein | Medium | convergence | {"qa_id":"medium_convergence_03376","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHMP6 and MVB12A each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Double and triple immunofluorescence, proxi... | |
medium_convergence_03377 | CSNK2A1 and CSNK2B both interact with a specific shared protein. Evidence indicates that, in addition to being phosphorylated by CK2, this protein interacts with the regulatory beta-subunit of protein kinase CK2 within high molecular mass complexes. Which biological process is this shared protein involved in? | negative regulation of G2/M transition of mitotic cell cycle | Medium | convergence | {"qa_id":"medium_convergence_03377","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2A1 and CSNK2B both interact with a specific shared protein. Evidence indicates that, in addition to being phosphorylated by CK2, this protein interacts ... | |
medium_convergence_03378 | COPS7A and COPS2 both interact with a shared protein partner. Evidence regarding this partner states: 'We demonstrated that the C-terminal half of the subunit encoded by the gene corresponding to this shared partner encompassing the PCI domain is responsible for interaction with CSN2, CSN3, and CSN4 subunits and is req... | COP9 signalosome complex subunit 1 | Medium | convergence | {"qa_id":"medium_convergence_03378","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS7A and COPS2 both interact with a shared protein partner. Evidence regarding this partner states: 'We demonstrated that the C-terminal half of the subuni... | |
medium_convergence_03379 | YAP1 and U2AF2 share multiple interacting partners. One such partner is reported to be poly-SUMOylated on lysine 233, a modification that enables it to bind YAP/TAZ. Which protein is encoded by the gene corresponding to this specific interacting partner? | Ubiquitin thioesterase OTUB2 | Medium | convergence | {"qa_id":"medium_convergence_03379","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and U2AF2 share multiple interacting partners. One such partner is reported to be poly-SUMOylated on lysine 233, a modification that enables it to bind ... | |
medium_convergence_03380 | Both Vaccinia virus and Human betaherpesvirus 5 are known to downregulate a specific shared gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -1.070 and an adjusted p-value of 0.001407. Which disease is associated with this gene? | glioma | Medium | convergence | {"qa_id":"medium_convergence_03380","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Vaccinia virus and Human betaherpesvirus 5 are known to downregulate a specific shared gene. Experimental data for this gene in a cervical adenocarcinom... | |
medium_convergence_03381 | BABAM1 and BRCA1 both interact with a common protein partner. Evidence indicates that this partner's COOH-terminal HECT-containing domain interacts with an NH(2)-terminal degron domain in BRCA1. Which cell type is this partner enriched in? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_03381","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BABAM1 and BRCA1 both interact with a common protein partner. Evidence indicates that this partner's COOH-terminal HECT-containing domain interacts with an N... | |
medium_convergence_03384 | KRT23 and KRT18 both interact with a specific keratin partner. Experimental evidence indicates that while K6 and K17 form very stable heterodimers, the interactions involving this shared partner and K18 are weaker. Which disease is associated with this shared partner through genomic alterations? | colorectal carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03384","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KRT23 and KRT18 both interact with a specific keratin partner. Experimental evidence indicates that while K6 and K17 form very stable heterodimers, the inter... | |
medium_convergence_03385 | Troglitazone and Imatinib share a common drug interaction partner. Evidence regarding this shared partner notes that typical CYP1A2 substrates generally contain a planar ring structure capable of fitting into the enzyme's narrow and planar active site; examples of such substrates include propranolol, clozapine, guanabe... | asthma | Medium | convergence | {"qa_id":"medium_convergence_03385","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Troglitazone and Imatinib share a common drug interaction partner. Evidence regarding this shared partner notes that typical CYP1A2 substrates generally cont... | |
medium_convergence_03386 | BOP1 and PELP1 both interact with a specific protein that is a component of the PeBoW complex. Evidence indicates that mutant M1 and M5 proteins associate with large pre-ribosomal complexes and co-immunoprecipitate Bop1 and this specific protein, confirming their proper incorporation into the PeBoW complex. Which prote... | Ribosome biogenesis protein WDR12 | Medium | convergence | {"qa_id":"medium_convergence_03386","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BOP1 and PELP1 both interact with a specific protein that is a component of the PeBoW complex. Evidence indicates that mutant M1 and M5 proteins associate wi... | |
medium_convergence_03387 | Both Measles morbillivirus and Cardiovirus A are known to upregulate a specific shared gene. Experimental data for this gene indicates a log2 fold change of 2.042 and an adjusted p-value of 0.001169. Which disease is associated with this gene as a biomarker? | seasonal allergic rhinitis | Medium | convergence | {"qa_id":"medium_convergence_03387","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Cardiovirus A are known to upregulate a specific shared gene. Experimental data for this gene indicates a log2 fold change of ... | |
medium_convergence_03388 | CREB1 and EP300 share multiple binding partners. One of these shared partners is involved in a mechanism where Cabin1 competes with p300 for binding to MEF2. Which disease is associated with this specific shared partner? | myxoma | Medium | convergence | {"qa_id":"medium_convergence_03388","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREB1 and EP300 share multiple binding partners. One of these shared partners is involved in a mechanism where Cabin1 competes with p300 for binding to MEF2.... | |
medium_convergence_03389 | GNG2 and PTH1R each interact with more than one shared protein. Evidence concerning one shared entity reports that Parathyroid hormone (PTH) and a related protein are calciotropic hormones interacting with a shared seven-transmembrane domain G protein-coupled receptor, which is located predominantly in bone and kidney.... | Parathyroid hormone-related protein | Medium | convergence | {"qa_id":"medium_convergence_03389","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNG2 and PTH1R each interact with more than one shared protein. Evidence concerning one shared entity reports that Parathyroid hormone (PTH) and a related pr... | |
medium_convergence_03390 | HDAC6 and SEPTIN9 share common interaction partners. One such shared partner is a component of the core septin hetero-octamer in human cells, which is composed of SEPT2, SEPT6, this shared partner, and SEPT9. Which protein is encoded by the gene corresponding to this shared partner? | Septin-7 | Medium | convergence | {"qa_id":"medium_convergence_03390","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC6 and SEPTIN9 share common interaction partners. One such shared partner is a component of the core septin hetero-octamer in human cells, which is compos... | |
medium_convergence_03391 | KHDRBS1 and EGFR share a common interacting partner. Evidence regarding this shared partner indicates that the formation of an intramolecular SH3-ligand complex prevents its SH3 domain and proline-rich region from interacting with the protein ligands Sam68 and Grb-2. Which protein is encoded by this shared interacting ... | Tyrosine-protein kinase ITK/TSK | Medium | convergence | {"qa_id":"medium_convergence_03391","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KHDRBS1 and EGFR share a common interacting partner. Evidence regarding this shared partner indicates that the formation of an intramolecular SH3-ligand comp... | |
medium_convergence_03392 | YAP1 and USP22 share a common interaction partner. Evidence indicates that USP22 interacts with this shared partner and stabilizes it by removing polyubiquitin chains conjugated onto it. Which protein is encoded by this shared interaction partner? | NAD-dependent protein deacetylase sirtuin-1 | Medium | convergence | {"qa_id":"medium_convergence_03392","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and USP22 share a common interaction partner. Evidence indicates that USP22 interacts with this shared partner and stabilizes it by removing polyubiquit... | |
medium_convergence_03393 | ATG16L1 and YWHAE both interact with a shared protein. Evidence indicates that this shared protein binds to the kinase domain of a specific RIPK family member and negatively regulates TLR2-mediated NF-κB activation and pro-inflammatory cytokine responses by inhibiting the interaction between TLR2 and this kinase. Which... | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_03393","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATG16L1 and YWHAE both interact with a shared protein. Evidence indicates that this shared protein binds to the kinase domain of a specific RIPK family membe... | |
medium_convergence_03394 | DVL2 and RAC1 share multiple interacting partners. One such shared partner is described in mechanistic studies as interacting with DVL2, an important upstream regulator for beta-catenin/TCF signaling, and activating this pathway. Which disease is associated with this specific shared partner via a biomarker relationship... | thyroid gland follicular carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03394","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DVL2 and RAC1 share multiple interacting partners. One such shared partner is described in mechanistic studies as interacting with DVL2, an important upstrea... | |
medium_convergence_03395 | KRT16 and KRT18 share a common interaction partner. Experimental evidence indicates that this partner interacts significantly with K16 and K18, and to some extent with K5, K6a, K8, and K14, as determined by two-hybrid methods. Which protein is encoded by the gene corresponding to this shared interaction partner? | Trichoplein keratin filament-binding protein | Medium | convergence | {"qa_id":"medium_convergence_03395","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KRT16 and KRT18 share a common interaction partner. Experimental evidence indicates that this partner interacts significantly with K16 and K18, and to some e... | |
medium_convergence_03396 | RHOA and RHOB both interact with a specific downstream kinase. Evidence indicates that transamidated RhoA functions as a constitutively active G-protein, exhibiting increased binding to this kinase, which is identified as RhoA-associated kinase-2 (ROCK-2). Which protein is encoded by the gene corresponding to this kina... | Rho-associated protein kinase 2 | Medium | convergence | {"qa_id":"medium_convergence_03396","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RHOA and RHOB both interact with a specific downstream kinase. Evidence indicates that transamidated RhoA functions as a constitutively active G-protein, exh... | |
medium_convergence_03397 | RUVBL2 and YWHAQ both interact with a specific gene product. Evidence indicates that Pontin interacts directly with this gene product and with dyskerin. Furthermore, the amount of this gene product bound to Pontin and Reptin peaks during the S phase, suggesting cell-cycle-dependent regulation. Which protein is encoded ... | Telomerase reverse transcriptase | Medium | convergence | {"qa_id":"medium_convergence_03397","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RUVBL2 and YWHAQ both interact with a specific gene product. Evidence indicates that Pontin interacts directly with this gene product and with dyskerin. Furt... | |
medium_convergence_03398 | CDH5 and PGF each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Overexpression of PlGF-1 in [the protein encoded by the shared entity]-producing tumor cells results in the formation of PlGF-1/[the protein encoded by the shared entity] heterodimers and depletion of the major... | Vascular endothelial growth factor A, long form | Medium | convergence | {"qa_id":"medium_convergence_03398","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDH5 and PGF each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Overexpression of PlGF-1 in [the protein encode... | |
medium_convergence_03399 | Both mmu-let-7b-5p and mmu-let-7d-5p regulate a specific type of T cell. A study using a mouse model describes a dual role for let-7 microRNAs in CD8 T cell responses, noting that while high let-7 expression maintains the naive phenotype, the generation of cytotoxic T lymphocytes depends on T cell receptor-mediated sig... | effector T cell | Medium | convergence | {"qa_id":"medium_convergence_03399","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both mmu-let-7b-5p and mmu-let-7d-5p regulate a specific type of T cell. A study using a mouse model describes a dual role for let-7 microRNAs in CD8 T cell ... | |
medium_convergence_03400 | PARD6A and ACVR2A share common binding partners. One such partner is an E3 ubiquitin ligase whose interaction with Par6 is controlled by Par6 phosphorylation, a process required for TGFbeta-dependent epithelial-mesenchymal transition in mammary gland epithelial cells. Which protein is encoded by this E3 ubiquitin ligas... | E3 ubiquitin-protein ligase SMURF1 | Medium | convergence | {"qa_id":"medium_convergence_03400","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARD6A and ACVR2A share common binding partners. One such partner is an E3 ubiquitin ligase whose interaction with Par6 is controlled by Par6 phosphorylation... | |
medium_convergence_03401 | ALMS1 and AJUBA both interact with a common protein partner. Evidence indicates that this shared partner interacts with Aurora-A in mitotic cells, resulting in phosphorylation of both proteins. Which cell type is this shared partner enriched in? | intermediate monocyte | Medium | convergence | {"qa_id":"medium_convergence_03401","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ALMS1 and AJUBA both interact with a common protein partner. Evidence indicates that this shared partner interacts with Aurora-A in mitotic cells, resulting ... | |
medium_convergence_03402 | Both the regulation of mast cell apoptotic process and the regulation of macrophage apoptotic process are subtypes of a shared biological process. Evidence for this shared process states: 'Any process that modulates the frequency, rate, or extent of mast cell apoptotic process.' Which biological process is directly reg... | myeloid cell apoptotic process | Medium | convergence | {"qa_id":"medium_convergence_03402","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the regulation of mast cell apoptotic process and the regulation of macrophage apoptotic process are subtypes of a shared biological process. Evidence f... | |
medium_convergence_03403 | TGFBR1 and UBB share common interacting partners. One such partner is described by evidence stating: 'Co-immunoprecipitation and ubiquitination assays revealed that this protein interacted with TβRI and deubiquitinated TβRI.' Which protein is encoded by the gene corresponding to this entity? | Ubiquitin carboxyl-terminal hydrolase 15 | Medium | convergence | {"qa_id":"medium_convergence_03403","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TGFBR1 and UBB share common interacting partners. One such partner is described by evidence stating: 'Co-immunoprecipitation and ubiquitination assays reveal... | |
medium_convergence_03404 | Both Human alphaherpesvirus 1 and Rhinovirus A are known to upregulate a specific shared gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 2.408 and an adjusted p-value of 0.006255. Which protein does this upregulated gene product inter... | DNAJC7 | Medium | convergence | {"qa_id":"medium_convergence_03404","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Rhinovirus A are known to upregulate a specific shared gene. Experimental data for this gene in a monocytic leukemia cell l... | |
medium_convergence_03405 | MCM7 and ORC2 both interact with a shared protein partner. Experimental evidence regarding this partner describes the following binary interactions: HsOrc2-HsOrc3, HsOrc2-HsOrc4, HsOrc3-HsOrc4, HsOrc2-HsOrc6, and HsOrc3-HsOrc6. Which protein is encoded by the gene corresponding to this shared partner? | Origin recognition complex subunit 6 | Medium | convergence | {"qa_id":"medium_convergence_03405","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MCM7 and ORC2 both interact with a shared protein partner. Experimental evidence regarding this partner describes the following binary interactions: HsOrc2-H... | |
medium_convergence_03406 | AP2A1 and AP2B1 both interact with a common protein partner. Experimental evidence indicates that this partner binds to beta2-Adaptin in yeast two-hybrid assays and co-immunoprecipitates with beta-arrestins and the beta-2 adrenergic receptor in an agonist-dependent manner in HEK-293 cells. Which disease is associated w... | leukemia | Medium | convergence | {"qa_id":"medium_convergence_03406","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AP2A1 and AP2B1 both interact with a common protein partner. Experimental evidence indicates that this partner binds to beta2-Adaptin in yeast two-hybrid ass... | |
medium_convergence_03407 | CLASP2 and MAPT are both associated with multiple shared biological processes. One such shared process is supported by evidence stating: 'We propose that CLASPs are involved in the local regulation of microtubule dynamics in response to positional cues.' Which biological process, connected to this shared entity via a '... | microtubule polymerization or depolymerization | Medium | convergence | {"qa_id":"medium_convergence_03407","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CLASP2 and MAPT are both associated with multiple shared biological processes. One such shared process is supported by evidence stating: 'We propose that CLA... | |
medium_convergence_03409 | Both Human immunodeficiency virus 1 and Zaire ebolavirus are known to downregulate a specific shared gene. Experimental data for this gene in a study (GSE108897) reports a log2 fold change of -1.990 and an adjusted p-value of 0.02872. Which cell type is this gene enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_03409","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Zaire ebolavirus are known to downregulate a specific shared gene. Experimental data for this gene in a study (GSE108... | |
medium_convergence_03410 | PPP2CB and PPP2R1A both interact with a shared gene product. Evidence indicates that this shared entity is separase, which associates with PP2A through the B' (B56) regulatory subunit independently of securin and cyclin B1 binding. Which disease is connected to this entity through a biomarker relationship? | acute megakaryoblastic leukemia in adult | Medium | convergence | {"qa_id":"medium_convergence_03410","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PPP2CB and PPP2R1A both interact with a shared gene product. Evidence indicates that this shared entity is separase, which associates with PP2A through the B... |
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