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medium_convergence_03411 | STX6 and STX2 both interact with a shared protein. Evidence indicates that in vitro binding studies established that SNAP-23 binds to syntaxin 6. Which cell type is enriched for this shared protein? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_03411","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STX6 and STX2 both interact with a shared protein. Evidence indicates that in vitro binding studies established that SNAP-23 binds to syntaxin 6. Which cell ... | |
medium_convergence_03412 | DCP2 and YWHAB both interact with a shared protein entity. Evidence regarding this entity states: 'In this study, we show that the target protein and the related proteins TIS11b and TIS11d bind specifically to 14-3-3 proteins and that individual 14-3-3 isoforms preferentially bind to different phosphorylated target pro... | mRNA decay activator protein ZFP36 | Medium | convergence | {"qa_id":"medium_convergence_03412","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCP2 and YWHAB both interact with a shared protein entity. Evidence regarding this entity states: 'In this study, we show that the target protein and the rel... | |
medium_convergence_03413 | HDAC6 and YWHAQ share multiple interacting partners. One of these shared partners was identified as a binding partner of a specific protein in a yeast two-hybrid assay where that protein served as the bait. Which disease is associated with this specific shared partner? | lung carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03413","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC6 and YWHAQ share multiple interacting partners. One of these shared partners was identified as a binding partner of a specific protein in a yeast two-hy... | |
medium_convergence_03414 | BMI1 and L3MBTL2 both interact with a specific protein. Evidence regarding this protein states: 'Further biochemical dissection revealed that the six PCGF-RING1A/B combinations form multiple complexes through association with [this protein] or its homolog YAF2, which prevents the incorporation of other canonical PRC1 s... | RING1 and YY1-binding protein | Medium | convergence | {"qa_id":"medium_convergence_03414","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMI1 and L3MBTL2 both interact with a specific protein. Evidence regarding this protein states: 'Further biochemical dissection revealed that the six PCGF-RI... | |
medium_convergence_03415 | EGFR and ZRANB1 share a common interacting partner. Experimental evidence indicates that when expressed in COS7 cells, epitope-tagged sorting nexins SNX1, SNX1A, this shared partner, and SNX4 co-immunoprecipitated with receptor tyrosine kinases for EGF, platelet-derived growth factor, and insulin. Which protein is enco... | Sorting nexin-2 | Medium | convergence | {"qa_id":"medium_convergence_03415","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and ZRANB1 share a common interacting partner. Experimental evidence indicates that when expressed in COS7 cells, epitope-tagged sorting nexins SNX1, SN... | |
medium_convergence_03416 | RNF31 and IKBKG both interact with a specific shared protein. Evidence indicates that this shared protein interacts via its PUB domain with CYLD, and a PUB interaction motif (PIM) within this protein interacts with the PUB domain of the LUBAC component HOIP. Which protein is encoded by the gene corresponding to this sh... | Spermatogenesis-associated protein 2 | Medium | convergence | {"qa_id":"medium_convergence_03416","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RNF31 and IKBKG both interact with a specific shared protein. Evidence indicates that this shared protein interacts via its PUB domain with CYLD, and a PUB i... | |
medium_convergence_03417 | CSNK1A1 and HMMR both interact with a specific shared protein. Evidence regarding this shared protein states: 'By means of a yeast two hybrid screening using this protein as bait, we identified the intracellular hyaluronic acid binding protein (IHABP) as a potential regulator of this protein.' Which protein is encoded ... | Transcription regulator protein BACH1 | Medium | convergence | {"qa_id":"medium_convergence_03417","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK1A1 and HMMR both interact with a specific shared protein. Evidence regarding this shared protein states: 'By means of a yeast two hybrid screening using... | |
medium_convergence_03418 | DCAF13 and DHX37 both interact with a shared protein. Evidence indicates that this shared protein is fibrillarin, a component of the core box C/D ribonucleoprotein complex involved in early pre-rRNA processing. Which gene encodes this protein? | rRNA 2'-O-methyltransferase fibrillarin | Medium | convergence | {"qa_id":"medium_convergence_03418","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCAF13 and DHX37 both interact with a shared protein. Evidence indicates that this shared protein is fibrillarin, a component of the core box C/D ribonucleop... | |
medium_convergence_03419 | CREBBP and GTF3A each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Phosphorylation of this entity induced its interaction with the transcriptional co-activator cAMP-response element binding protein-binding protein.' Which cell type is that entity enriched in? | regulatory T cell | Medium | convergence | {"qa_id":"medium_convergence_03419","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and GTF3A each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Phosphorylation of this entity induced... | |
medium_convergence_03420 | Rhinovirus A and Human gammaherpesvirus 8 both downregulate a specific gene. In cytotoxic T-lymphocytes, experimental data for this gene shows a log2 fold change of approximately -1.386 and an adjusted p-value of 0.01367. Which protein does this gene product bind to? | RIGI | Medium | convergence | {"qa_id":"medium_convergence_03420","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Human gammaherpesvirus 8 both downregulate a specific gene. In cytotoxic T-lymphocytes, experimental data for this gene shows a log2 fold ch... | |
medium_convergence_03421 | MED1 and NCOR1 both interact with a specific nuclear receptor. Evidence regarding this receptor states: 'Here we show that the pregnane X receptor interacts more strongly with SMRTalpha than with SMRTtau both in vitro and in vivo.' Which protein is encoded by the gene corresponding to this nuclear receptor? | Nuclear receptor subfamily 1 group I member 2 | Medium | convergence | {"qa_id":"medium_convergence_03421","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MED1 and NCOR1 both interact with a specific nuclear receptor. Evidence regarding this receptor states: 'Here we show that the pregnane X receptor interacts ... | |
medium_convergence_03422 | CREBBP and ELAVL1 share multiple interacting partners. One such partner is described in evidence stating: 'We report here that ProTalpha physically interacts with the CREB-binding protein (CBP), which is a versatile transcription co-activator.' Which gene encodes the protein referred to as ProTalpha in this context? | Prothymosin alpha | Medium | convergence | {"qa_id":"medium_convergence_03422","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and ELAVL1 share multiple interacting partners. One such partner is described in evidence stating: 'We report here that ProTalpha physically interacts... | |
medium_convergence_03424 | BRD4 and HIST1H1A share a common interacting partner. Evidence regarding this shared partner states: 'Among previously identified core histone chaperones and linker histone chaperone candidates, only a specific histone chaperone complex was found to be associated specifically with histone H1 in mammalian somatic cell n... | Protein SET | Medium | convergence | {"qa_id":"medium_convergence_03424","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD4 and HIST1H1A share a common interacting partner. Evidence regarding this shared partner states: 'Among previously identified core histone chaperones and... | |
medium_convergence_03425 | Both 3rd arch mesenchyme from neural crest and 4th arch mesenchyme from neural crest are subtypes of a shared anatomical entity. Evidence indicates that this shared entity is a mesenchyme that develops from a neural crest and is part of a 3rd arch mesenchyme. Which anatomical structure is this shared entity a part of? | entire pharyngeal arch associated mesenchyme | Medium | convergence | {"qa_id":"medium_convergence_03425","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both 3rd arch mesenchyme from neural crest and 4th arch mesenchyme from neural crest are subtypes of a shared anatomical entity. Evidence indicates that this... | |
medium_convergence_03426 | CDH3 and CDHR1 both interact with a shared protein partner. Experimental evidence regarding this partner states: 'Co-immunoprecipitation studies carried out on viable cells confirmed previously observed complexes between cadherins and alpha and beta catenin and between the catenins themselves.' Which protein is encoded... | Catenin alpha-1 | Medium | convergence | {"qa_id":"medium_convergence_03426","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDH3 and CDHR1 both interact with a shared protein partner. Experimental evidence regarding this partner states: 'Co-immunoprecipitation studies carried out ... | |
medium_convergence_03429 | KAT5 and RPA1 both physically interact with a specific shared protein. Experimental evidence regarding this shared protein indicates that its binding motif, identified via ELISA using deletion mutants, is located within amino acids 100-300 and overlaps with the single-stranded DNA binding domain (amino acids 150-450). ... | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN | Medium | convergence | {"qa_id":"medium_convergence_03429","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KAT5 and RPA1 both physically interact with a specific shared protein. Experimental evidence regarding this shared protein indicates that its binding motif, ... | |
medium_convergence_03430 | Both Measles morbillivirus and Rift Valley fever phlebovirus are reported to upregulate a specific gene. In a study of pleural mesothelioma cells (GSE117668), this gene showed a log2 fold change of 1.291 and an adjusted p-value of 0.002292. Which protein is encoded by this gene? | GTP cyclohydrolase 1 | Medium | convergence | {"qa_id":"medium_convergence_03430","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Rift Valley fever phlebovirus are reported to upregulate a specific gene. In a study of pleural mesothelioma cells (GSE117668)... | |
medium_convergence_03431 | Both IKBKG and FADD interact with a common protein. Evidence regarding this shared partner states: 'Similarly, the RICK-related kinase [shared partner] associated via its intermediate region with IKKgamma.' Which cell type is this shared protein enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_03431","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both IKBKG and FADD interact with a common protein. Evidence regarding this shared partner states: 'Similarly, the RICK-related kinase [shared partner] assoc... | |
medium_convergence_03432 | NUP50 and HDAC2 both interact with a specific protein. Evidence regarding this shared interaction partner states: 'The N terminus binds the C terminus of importin-alpha, while a central domain binds importin-beta.' Which protein is encoded by this shared interaction partner? | Importin subunit alpha-1 | Medium | convergence | {"qa_id":"medium_convergence_03432","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NUP50 and HDAC2 both interact with a specific protein. Evidence regarding this shared interaction partner states: 'The N terminus binds the C terminus of imp... | |
medium_convergence_03433 | CHEK1 and VIRMA share multiple interacting partners. One such shared partner is identified in a study reporting the identification of the heterohexamic minichromosome maintenance (MCM) complex that interacts with Chk1 by mass spectrometry. Which protein is encoded by this shared interacting partner? | DNA replication licensing factor MCM4 | Medium | convergence | {"qa_id":"medium_convergence_03433","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK1 and VIRMA share multiple interacting partners. One such shared partner is identified in a study reporting the identification of the heterohexamic minic... | |
medium_convergence_03434 | TRIM28 and CCT8 share common interaction partners. One such partner is part of a PP4C/R3β complex that interacts with KAP-1; silencing this complex results in the persistence of phospho-S824 and phospho-S473. Which cell type is enriched for this specific shared partner? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_03434","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and CCT8 share common interaction partners. One such partner is part of a PP4C/R3β complex that interacts with KAP-1; silencing this complex results i... | |
medium_convergence_03435 | FBXW7 and USP7 share multiple interacting partners. One such partner is characterized by evidence stating: 'Here, we show that ERK1/2 pathway activation triggers the interaction of this protein with the ubiquitin-specific protease USP7.' Which protein is encoded by this specific shared partner? | Leucine-rich repeat protein SHOC-2 | Medium | convergence | {"qa_id":"medium_convergence_03435","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FBXW7 and USP7 share multiple interacting partners. One such partner is characterized by evidence stating: 'Here, we show that ERK1/2 pathway activation trig... | |
medium_convergence_03436 | CDC16 and CDC20 both interact with a specific shared protein complex component. Experimental evidence indicates that in extracts prepared from M phase, but not from interphase HeLa cells, p55CDC coimmunoprecipitates with three important elements of the M phase checkpoint machinery: this shared component, CDC16, and Mad... | CDH1 | Medium | convergence | {"qa_id":"medium_convergence_03436","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC16 and CDC20 both interact with a specific shared protein complex component. Experimental evidence indicates that in extracts prepared from M phase, but n... | |
medium_convergence_03437 | PPARG and RXRA both interact with a specific transcription factor. Evidence indicates that this factor forms a transcriptionally active complex with unliganded RAR/RXR heterodimers on the PDGF-A promoter, and that Am80 disrupts this complex to inhibit the factor-dependent transcriptional activation. Which cell type is ... | basophil | Medium | convergence | {"qa_id":"medium_convergence_03437","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PPARG and RXRA both interact with a specific transcription factor. Evidence indicates that this factor forms a transcriptionally active complex with unligand... | |
medium_convergence_03438 | TOPBP1 and ZNF689 share common interaction partners. One such shared partner is functionally analogous to the budding yeast protein Fun30, as both are cell cycle-regulated through interaction with the DSB-localized scaffold protein Dpb11 (in yeast) or TOPBP1 (in human). Which protein encodes this human shared partner? | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 | Medium | convergence | {"qa_id":"medium_convergence_03438","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TOPBP1 and ZNF689 share common interaction partners. One such shared partner is functionally analogous to the budding yeast protein Fun30, as both are cell c... | |
medium_convergence_03439 | BRD4 and ANLN both interact with a shared protein. Evidence indicates that this shared protein binds directly to the largest subunit, RFC-140, thereby interacting with the entire RFC complex. Which protein is encoded by this shared entity? | Replication factor C subunit 1 | Medium | convergence | {"qa_id":"medium_convergence_03439","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD4 and ANLN both interact with a shared protein. Evidence indicates that this shared protein binds directly to the largest subunit, RFC-140, thereby intera... | |
medium_convergence_03440 | GTF2E1 and ELL both interact with a shared protein partner. Evidence regarding this partner indicates that analyses of its binding to other general transcription factors revealed defects in binding to the basic helix-loop-helix motif of TFIIEβ. Which disease is associated with this shared protein partner? | trichothiodystrophy 6, nonphotosensitive | Medium | convergence | {"qa_id":"medium_convergence_03440","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GTF2E1 and ELL both interact with a shared protein partner. Evidence regarding this partner indicates that analyses of its binding to other general transcrip... | |
medium_convergence_03441 | Both Human gammaherpesvirus 4 and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. In a study of gamma delta T-lymphocytes (GSE13906), this gene exhibited a log2 fold change of -1.415 and an adjusted p-value of 0.03107. Which protein is encoded by this gen... | Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 | Medium | convergence | {"qa_id":"medium_convergence_03441","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human gammaherpesvirus 4 and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. In a study... | |
medium_convergence_03442 | EGF and EPN1 share common binding partners. One such shared partner is implicated in an interaction where the EH domain of a specific protein binds directly to the region containing the NPF motifs of Epsin. Which protein is encoded by the gene corresponding to this shared partner? | RalBP1-associated Eps domain-containing protein 2 | Medium | convergence | {"qa_id":"medium_convergence_03442","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGF and EPN1 share common binding partners. One such shared partner is implicated in an interaction where the EH domain of a specific protein binds directly ... | |
medium_convergence_03444 | FBXW11 and PRKN each interact with more than one shared gene. Evidence concerning one shared entity reports: 'We found that both beta-Trcp1 and beta-Trcp2 bind specifically to this entity, and point mutations in the beta-Trcp WD-repeat region completely abolished its binding, indicating an E3-substrate-type interaction... | gastric carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03444","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FBXW11 and PRKN each interact with more than one shared gene. Evidence concerning one shared entity reports: 'We found that both beta-Trcp1 and beta-Trcp2 bi... | |
medium_convergence_03445 | LIN54 and LIN52 both interact with a shared protein partner. Evidence regarding one such partner states: 'Using an integrated approach combining proteomics, genomics, and bioinformatic analyses, we identified a complex termed DP, RB-like, E2F, and MuvB (DREAM) that contains mammalian homologs of synMuvB proteins LIN-9,... | hepatocellular carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03445","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LIN54 and LIN52 both interact with a shared protein partner. Evidence regarding one such partner states: 'Using an integrated approach combining proteomics, ... | |
medium_convergence_03446 | LGR4 and LGR5 both interact with a specific protein. Mechanistic evidence indicates that R-spondin interacts with the extracellular domain of this protein and induces its association with LGR4, resulting in the membrane clearance of this protein. Which disease is associated with this protein through genomic alterations... | primary angle-closure glaucoma | Medium | convergence | {"qa_id":"medium_convergence_03446","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LGR4 and LGR5 both interact with a specific protein. Mechanistic evidence indicates that R-spondin interacts with the extracellular domain of this protein an... | |
medium_convergence_03447 | COPS6 and JUN each interact with more than one shared protein. Evidence concerning one such shared entity states: 'We show for the first time that COP9 signalosome subunit 6 (CSN6) associates with [REDACTED_SHARED_PROTEIN] and is involved in 14-3-3σ ubiquitin-mediated degradation.' Which protein is connected to that en... | E3 ubiquitin-protein ligase COP1 | Medium | convergence | {"qa_id":"medium_convergence_03447","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS6 and JUN each interact with more than one shared protein. Evidence concerning one such shared entity states: 'We show for the first time that COP9 signa... | |
medium_convergence_03448 | CHD3 and BRD4 both interact with a specific shared protein. Evidence indicates that phosphorylation of KAP-1 at Ser824 generates a motif that directly perturbs interactions between this shared protein's SUMO-interacting motif and the protein itself, causing the protein to disperse from heterochromatin double-strand bre... | Small ubiquitin-related modifier 1 | Medium | convergence | {"qa_id":"medium_convergence_03448","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD3 and BRD4 both interact with a specific shared protein. Evidence indicates that phosphorylation of KAP-1 at Ser824 generates a motif that directly pertur... | |
medium_convergence_03449 | HDAC6 and HUWE1 both interact with a specific shared protein. Experimental evidence indicates that the interaction between this shared protein and tubulin is independent of other proteins. Which disease is associated with this shared protein through genomic alterations? | multiple benign circumferential skin creases on limbs 1 | Medium | convergence | {"qa_id":"medium_convergence_03449","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC6 and HUWE1 both interact with a specific shared protein. Experimental evidence indicates that the interaction between this shared protein and tubulin is... | |
medium_convergence_03450 | DNA2 and RAD51 both interact with a common protein partner. Experimental evidence indicates that phosphorylation of RAD51 by c-Abl enhances the formation of a complex between RAD51 and this shared partner, which cooperates with RAD51 in recombination and repair processes. Which protein is encoded by the gene correspond... | DNA repair protein RAD52 homolog | Medium | convergence | {"qa_id":"medium_convergence_03450","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNA2 and RAD51 both interact with a common protein partner. Experimental evidence indicates that phosphorylation of RAD51 by c-Abl enhances the formation of ... | |
medium_convergence_03451 | IRF7 and CD36 both interact with a common protein. Evidence regarding this shared partner indicates that its death domain interacts with an inhibitory domain of IRF7, leading to the activation of IFN-alpha-dependent promoters. Which protein is encoded by the gene corresponding to this shared partner? | Myeloid differentiation primary response protein MyD88 | Medium | convergence | {"qa_id":"medium_convergence_03451","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IRF7 and CD36 both interact with a common protein. Evidence regarding this shared partner indicates that its death domain interacts with an inhibitory domain... | |
medium_convergence_03452 | GNG10 and ARRB1 both physically interact with a specific protein. Experimental evidence indicates that beta-arrestin 1 physically interacts with the delta opioid receptor (DOR) in an agonist-enhanced manner when co-expressed in human embryonic kidney 293 cells, and that truncation of the carboxyl terminus of DOR partia... | gastric carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03452","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNG10 and ARRB1 both physically interact with a specific protein. Experimental evidence indicates that beta-arrestin 1 physically interacts with the delta op... | |
medium_convergence_03453 | OPTN and CCT2 both interact with a shared protein. Evidence indicates that this shared protein associates with aggregation-prone proteins independent of cargo ubiquitination and interacts with autophagosome marker ATG8s through a non-classical VLIR motif. Which disease is connected to this protein through a biomarker r... | schizophrenia | Medium | convergence | {"qa_id":"medium_convergence_03453","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"OPTN and CCT2 both interact with a shared protein. Evidence indicates that this shared protein associates with aggregation-prone proteins independent of carg... | |
medium_convergence_03454 | GNB1 and PTHLH both interact with a shared receptor protein. Evidence indicates that this receptor is a seven-transmembrane domain G protein-coupled receptor that binds both Parathyroid hormone (PTH) and PTH-related protein (PTHrP), and is predominantly located in bone and kidney. Which protein is encoded by the gene c... | Parathyroid hormone/parathyroid hormone-related peptide receptor | Medium | convergence | {"qa_id":"medium_convergence_03454","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNB1 and PTHLH both interact with a shared receptor protein. Evidence indicates that this receptor is a seven-transmembrane domain G protein-coupled receptor... | |
medium_convergence_03455 | RACK1 and DYRK1A share common interaction partners. One such shared partner is implicated in a study where pull-down and immunoprecipitation assays revealed that type II PKA interacted with IFNAR2 via RACK1, an interaction inhibited by luteolin. Which protein is encoded by this shared interaction partner? | cAMP-dependent protein kinase type II-alpha regulatory subunit | Medium | convergence | {"qa_id":"medium_convergence_03455","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RACK1 and DYRK1A share common interaction partners. One such shared partner is implicated in a study where pull-down and immunoprecipitation assays revealed ... | |
medium_convergence_03456 | CREBBP and CTNNB1 share a common binding partner. Evidence indicates that the CR2C and CR3 domains of this shared entity interact with the KIX domain of CBP/p300 at both 'MLL' and 'c-Myb' binding sites simultaneously. Which protein is encoded by this shared entity? | Forkhead box protein O3 | Medium | convergence | {"qa_id":"medium_convergence_03456","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and CTNNB1 share a common binding partner. Evidence indicates that the CR2C and CR3 domains of this shared entity interact with the KIX domain of CBP/... | |
medium_convergence_03457 | Rhinovirus A and Human gammaherpesvirus 8 both downregulate a specific gene. In a study of cytotoxic T-lymphocytes (GSE106475), this gene exhibited a log2 fold change of -1.413 and an adjusted p-value of 0.001292. Which protein is encoded by this gene? | Proepiregulin | Medium | convergence | {"qa_id":"medium_convergence_03457","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Human gammaherpesvirus 8 both downregulate a specific gene. In a study of cytotoxic T-lymphocytes (GSE106475), this gene exhibited a log2 fo... | |
medium_convergence_03459 | JAK1 and JAK3 both interact with a specific regulatory protein. Evidence indicates that the kinase inhibitory region of this protein targets the substrate binding groove of JAK with high specificity, thereby blocking subsequent phosphorylation. Which protein product is encoded by the gene corresponding to this regulato... | Suppressor of cytokine signaling 1 | Medium | convergence | {"qa_id":"medium_convergence_03459","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"JAK1 and JAK3 both interact with a specific regulatory protein. Evidence indicates that the kinase inhibitory region of this protein targets the substrate bi... | |
medium_convergence_03460 | CEBPB and E2F1 share multiple interacting partners. One such shared partner is described by the evidence: 'All four factors of the Sp1 family are able to bind E2F-1 in co-immunoprecipitation and GST-pull down experiments.' Which cell type is enriched for this specific shared partner? | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_03460","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CEBPB and E2F1 share multiple interacting partners. One such shared partner is described by the evidence: 'All four factors of the Sp1 family are able to bin... | |
medium_convergence_03461 | KDM1A and HDAC1 share multiple interacting partners. One such partner is identified by evidence stating: 'Here we report that a proline-rich domain in a transcriptional repressor directly interacts with LSD1, a histone lysine demethylase.' Which biological process is this specific partner involved in? | negative regulation of transcription by RNA polymerase II | Medium | convergence | {"qa_id":"medium_convergence_03461","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KDM1A and HDAC1 share multiple interacting partners. One such partner is identified by evidence stating: 'Here we report that a proline-rich domain in a tran... | |
medium_convergence_03462 | PRKDC and TTI2 share common interaction partners. One such shared partner is characterized by evidence stating that it interacts with and stabilizes all six members of the PIKK family of proteins (mTOR, ATM, ATR, DNA-PKcs, SMG-1, and TRRAP). Which disease is associated with this specific shared partner? | neurodevelopmental disorder with microcephaly and movement abnormalities | Medium | convergence | {"qa_id":"medium_convergence_03462","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKDC and TTI2 share common interaction partners. One such shared partner is characterized by evidence stating that it interacts with and stabilizes all six ... | |
medium_convergence_03463 | CEBPB and XRCC6 share a common interacting partner. Evidence for one such partner indicates that Yeast two-hybrid screening detected an interaction between the bromodomain of hGCN5 and the p70 subunit of the human Ku heterodimer (p70-p80), which serves as the DNA-binding component of DNA-PK. Which cell type is enriched... | memory B cell | Medium | convergence | {"qa_id":"medium_convergence_03463","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CEBPB and XRCC6 share a common interacting partner. Evidence for one such partner indicates that Yeast two-hybrid screening detected an interaction between t... | |
medium_convergence_03465 | EP300 and NCOA1 share multiple binding partners. One such shared partner is implicated in a context where the C-terminus of a protein encoded by this partner binds to CBP/p300 and DRIP130, suggesting this protein may activate transcription through these interactions. Which protein is encoded by this shared partner? | Nuclear receptor coactivator 6 | Medium | convergence | {"qa_id":"medium_convergence_03465","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and NCOA1 share multiple binding partners. One such shared partner is implicated in a context where the C-terminus of a protein encoded by this partner... | |
medium_convergence_03466 | Human polyomavirus 1 and Human immunodeficiency virus 1 both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) reports a log2 fold change of approximately 2.03 and an adjusted p-value of approximately 0.04. Which disease is associated with this gene? | nervous system disorder | Medium | convergence | {"qa_id":"medium_convergence_03466","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Human immunodeficiency virus 1 both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE... | |
medium_convergence_03467 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific shared gene. Experimental data for this gene reports a log2 fold change of approximately 3.275 and an adjusted p-value of approximately 0.0078. In which cell type is this gene enriched? | naive B cell | Medium | convergence | {"qa_id":"medium_convergence_03467","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific shared gene. Experimental data for this gene reports a log2 fold change of ap... | |
medium_convergence_03468 | CDC37 and PRKN each interact with more than one shared gene product. Evidence concerning one shared entity reports that mutation of a protein phosphatase 5 isoform, replacing key basic amino acids (K97A and R101A) in the tetratricopeptide repeat (TPR) region known to be necessary for interactions with Hsp90, abolished ... | Serine/threonine-protein phosphatase 5 | Medium | convergence | {"qa_id":"medium_convergence_03468","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC37 and PRKN each interact with more than one shared gene product. Evidence concerning one shared entity reports that mutation of a protein phosphatase 5 i... | |
medium_convergence_03469 | YAP1 and EP300 share multiple interacting partners. One such partner is described as interacting with YAP protein via its OTU domain (Ovarian tumor domain) and deubiquitinating YAP at specific lysine sites (K90, K280, K343, K494, and K497), thereby inhibiting YAP degradation. Which cellular component is this specific p... | extracellular exosome | Medium | convergence | {"qa_id":"medium_convergence_03469","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and EP300 share multiple interacting partners. One such partner is described as interacting with YAP protein via its OTU domain (Ovarian tumor domain) a... | |
medium_convergence_03470 | BIRC2 and CBL both interact with a specific ubiquitin-conjugating enzyme. Experimental evidence indicates that this enzyme, along with members of the Ube2e family and Ube2n/2v1, catalyzes the autoubiquitination of the Cbl protein and mediates the ubiquitination of EGFR and SYK substrates. Which protein product is encod... | Ubiquitin-conjugating enzyme E2 D3 | Medium | convergence | {"qa_id":"medium_convergence_03470","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC2 and CBL both interact with a specific ubiquitin-conjugating enzyme. Experimental evidence indicates that this enzyme, along with members of the Ube2e f... | |
medium_convergence_03471 | The sphenoid region and the sphenoid bone pre-cartilage condensation are both components of a shared anatomical structure. Evidence regarding this shared structure describes it as an anatomical cluster that forms the floor and sidewalls of the middle part of the cranium. What is the primary subdivision classification o... | primary subdivision of cranial skeletal system | Medium | convergence | {"qa_id":"medium_convergence_03471","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The sphenoid region and the sphenoid bone pre-cartilage condensation are both components of a shared anatomical structure. Evidence regarding this shared str... | |
medium_convergence_03472 | ATG13 and RB1CC1 both interact with a specific kinase. Evidence regarding this kinase states: 'This phosphorylation inhibited the kinase activity, preventing it from binding to the downstream effector ATG13, and reduced autophagy in microglia.' Which protein is encoded by the gene corresponding to this kinase? | Serine/threonine-protein kinase ULK1 | Medium | convergence | {"qa_id":"medium_convergence_03472","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATG13 and RB1CC1 both interact with a specific kinase. Evidence regarding this kinase states: 'This phosphorylation inhibited the kinase activity, preventing... | |
medium_convergence_03473 | VPS11 and VPS16 both interact with a shared protein. Evidence indicates that this shared protein acts as a molecular switch within the shared core of CORVET/HOPS, binding either CORVET-specific components or HOPS-specific VPS39/RILP to allow selective targeting of these tethering complexes to early or late endosomes. W... | Transforming growth factor-beta receptor-associated protein 1 | Medium | convergence | {"qa_id":"medium_convergence_03473","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"VPS11 and VPS16 both interact with a shared protein. Evidence indicates that this shared protein acts as a molecular switch within the shared core of CORVET/... | |
medium_convergence_03474 | PIGA and PIGC each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Here we demonstrate 1) that PIG-A is an ER transmembrane protein with a large cytoplasmic domain that has homology to a bacterial GlcNAc transferase and a small lumenal domain; 2) that PIG-H is a ... | Phosphatidylinositol N-acetylglucosaminyltransferase subunit H | Medium | convergence | {"qa_id":"medium_convergence_03474","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PIGA and PIGC each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Here we demonstrate 1) that PIG-A... | |
medium_convergence_03475 | Cimetidine and Zafirlukast share a common drug interaction partner. Evidence regarding one such shared partner notes that 'more profound effects were observed at the sub-therapeutic dose combination of zafirlukast (15mg/kg) and this shared partner (5mg/kg).' Which disease is this specific shared drug indicated for? | osteoarthritis | Medium | convergence | {"qa_id":"medium_convergence_03475","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cimetidine and Zafirlukast share a common drug interaction partner. Evidence regarding one such shared partner notes that 'more profound effects were observe... | |
medium_convergence_03476 | SIRT1 and SIN3A both interact with a shared transcription factor. Evidence indicates that SIRT1 interacts directly with this factor and is recruited to the promoter template in a manner dependent on this factor, resulting in transcriptional repression. Which disease is associated with this transcription factor? | Dias-Logan syndrome | Medium | convergence | {"qa_id":"medium_convergence_03476","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIRT1 and SIN3A both interact with a shared transcription factor. Evidence indicates that SIRT1 interacts directly with this factor and is recruited to the p... | |
medium_convergence_03477 | Measles morbillivirus and Cardiovirus A both downregulate a specific gene. Evidence for this gene in study GSE131840 reports a log2 fold change of approximately -1.043 and an adjusted p-value of 0.005528. In which cell type is this gene enriched? | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_03477","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Measles morbillivirus and Cardiovirus A both downregulate a specific gene. Evidence for this gene in study GSE131840 reports a log2 fold change of approximat... | |
medium_convergence_03478 | EIF2S3 and EIF3C each share a binding partner. For one of these shared partners, experimental evidence indicates that it interacts directly with EIF3C, EIF3G, and EIF3J via glutathione S-transferase pull-down assays. Which protein is encoded by this specific shared partner? | Eukaryotic translation initiation factor 3 subunit K | Medium | convergence | {"qa_id":"medium_convergence_03478","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF2S3 and EIF3C each share a binding partner. For one of these shared partners, experimental evidence indicates that it interacts directly with EIF3C, EIF3G... | |
medium_convergence_03479 | Both Human orthopneumovirus and Zika virus are associated with the upregulation of a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 1.091 and an adjusted p-value of 0.03326. Which protein is encoded by this gene? | Phosphoacetylglucosamine mutase | Medium | convergence | {"qa_id":"medium_convergence_03479","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human orthopneumovirus and Zika virus are associated with the upregulation of a specific gene. Experimental data for this gene in cytotoxic T-lymphocyte... | |
medium_convergence_03480 | RACK1 and RPGRIP1L share common interaction partners. One such partner is identified in experimental evidence stating: 'This screen identified receptor for activated C-kinase 1 (RACK1) as a new TPbeta-interacting protein.' Which protein, encoded by the gene corresponding to this TPbeta-interacting partner, is the targe... | Thromboxane A2 receptor | Medium | convergence | {"qa_id":"medium_convergence_03480","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RACK1 and RPGRIP1L share common interaction partners. One such partner is identified in experimental evidence stating: 'This screen identified receptor for a... | |
medium_convergence_03481 | HSPA9 and ATXN3 both interact with a specific shared protein. Evidence regarding this shared protein states: 'Here, we report a new molecular interaction between wild-type ataxin-3 and this protein, using in vitro and in situ approaches.' Which protein is encoded by this shared gene? | Ubiquitin-like protein NEDD8 | Medium | convergence | {"qa_id":"medium_convergence_03481","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA9 and ATXN3 both interact with a specific shared protein. Evidence regarding this shared protein states: 'Here, we report a new molecular interaction bet... | |
medium_convergence_03482 | EWSR1 and FMR1 share multiple interacting partners. One such shared partner is supported by evidence stating: 'A set of biochemical experiments revealed an interaction of this protein with FMRP, the product of the gene affected in Fragile X syndrome, and its autosomal homologs FXR1 and FXR2.' Which protein is encoded b... | Tudor domain-containing protein 3 | Medium | convergence | {"qa_id":"medium_convergence_03482","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EWSR1 and FMR1 share multiple interacting partners. One such shared partner is supported by evidence stating: 'A set of biochemical experiments revealed an i... | |
medium_convergence_03483 | CHM and GDI2 both interact with a shared protein. Evidence regarding this shared protein states: 'Here we report in vitro assembly, purification, and crystallization of the monoprenylated Rab7GDP:REP-1 complex.' Which protein is encoded by the gene corresponding to this shared entity? | Ras-related protein Rab-7a | Medium | convergence | {"qa_id":"medium_convergence_03483","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHM and GDI2 both interact with a shared protein. Evidence regarding this shared protein states: 'Here we report in vitro assembly, purification, and crystal... | |
medium_convergence_03485 | COPS5 and HSPA4 both interact with a specific shared protein. Experimental evidence indicates that HSP70 binds to this shared protein, and in vitro, the conversion of this protein's chains into monomers stimulates HSP70 ATPase activity. Which protein is encoded by the gene corresponding to this shared entity? | Ubiquitin-like protein NEDD8 | Medium | convergence | {"qa_id":"medium_convergence_03485","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS5 and HSPA4 both interact with a specific shared protein. Experimental evidence indicates that HSP70 binds to this shared protein, and in vitro, the conv... | |
medium_convergence_03486 | DLAT and SIRT3 share multiple interacting partners. One such shared partner is characterized by evidence stating: 'The E2 60-mer bound approximately 18 [entity] dimers with a Kd similar to GST-L2.' Which disease is associated with this specific shared entity? | polycystic kidney disease 2 | Medium | convergence | {"qa_id":"medium_convergence_03486","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLAT and SIRT3 share multiple interacting partners. One such shared partner is characterized by evidence stating: 'The E2 60-mer bound approximately 18 [enti... | |
medium_convergence_03487 | Both IRAK1 and IRAK4 interact with a specific shared protein. Experimental evidence indicates that IRAK-1 directly binds to and phosphorylates this shared protein in vitro. Which cell type is this shared protein enriched in? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_03487","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both IRAK1 and IRAK4 interact with a specific shared protein. Experimental evidence indicates that IRAK-1 directly binds to and phosphorylates this shared pr... | |
medium_convergence_03488 | CD3D and CD247 each interact with more than one shared protein partner. Evidence concerning one such shared entity reports that CD3 delta was selectively co-immunoprecipitated with antibodies against a specific T-cell surface glycoprotein, indicating an avid association of that glycoprotein with CD3 delta. Which protei... | T-cell surface glycoprotein CD8 alpha chain | Medium | convergence | {"qa_id":"medium_convergence_03488","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CD3D and CD247 each interact with more than one shared protein partner. Evidence concerning one such shared entity reports that CD3 delta was selectively co-... | |
medium_convergence_03489 | BTC and CBL each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here, we demonstrate that h[Entity] associates directly with c-Cbl, a known down-regulator of RTK signaling.' Which disease is connected to that entity through genomic alterations? | Metaphyseal chondrodysplasia, McKusick type | Medium | convergence | {"qa_id":"medium_convergence_03489","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BTC and CBL each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here, we demonstrate that h[Entity] associates d... | |
medium_convergence_03490 | The biological processes 'positive regulation of protein-containing complex assembly' and 'positive regulation of cell junction assembly' share a common parent process. Evidence regarding one of these shared entities states: 'Any process that activates or increases the frequency, rate or extent of protein complex assem... | cellular component organization | Medium | convergence | {"qa_id":"medium_convergence_03490","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The biological processes 'positive regulation of protein-containing complex assembly' and 'positive regulation of cell junction assembly' share a common pare... | |
medium_convergence_03491 | TADA1 and KAT2A both interact with a shared protein entity. Evidence regarding this entity states: 'Here we show that Myc co-recruits the shared entity and GCN5 via direct physical interactions of its N-terminal activation/transformation domain with the human STAGA (SPT3-TAF-GCN5 acetylase) coactivator complex.' Which ... | melanoma | Medium | convergence | {"qa_id":"medium_convergence_03491","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TADA1 and KAT2A both interact with a shared protein entity. Evidence regarding this entity states: 'Here we show that Myc co-recruits the shared entity and G... | |
medium_convergence_03492 | Acetohexamide and Methotrexate both interact with a specific shared drug. Evidence regarding this shared drug indicates that combined treatment during pubertal and adult periods induces male-specific reductase activity in the liver microsomes of female rats. Which disease is this shared drug indicated for? | hypogonadotropic hypogonadism | Medium | convergence | {"qa_id":"medium_convergence_03492","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Acetohexamide and Methotrexate both interact with a specific shared drug. Evidence regarding this shared drug indicates that combined treatment during pubert... | |
medium_convergence_03493 | AKAP9 and BRAF both interact with a shared protein kinase. Evidence regarding this shared entity states: 'Members of the raf oncogene family encode serine/threonine protein kinases, which activate the mitogen-activated protein kinase kinase MEKs (MAPK or ERK kinases) through direct interaction and phosphorylation.' Whi... | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_03493","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKAP9 and BRAF both interact with a shared protein kinase. Evidence regarding this shared entity states: 'Members of the raf oncogene family encode serine/th... | |
medium_convergence_03494 | TRAF6 and RNF34 both interact with a shared protein. Evidence regarding one such shared partner states: 'We report the identification of a TRAF-interacting protein, T6BP, that specifically associates with TRAF6.' Which protein is encoded by the gene corresponding to that entity? | Tax1-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_03494","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRAF6 and RNF34 both interact with a shared protein. Evidence regarding one such shared partner states: 'We report the identification of a TRAF-interacting p... | |
medium_convergence_03496 | PARP1 and PRKN share multiple interacting partners. One such partner is described in a study reporting an interphase-specific interaction between condensin I and the DNA nick-sensor poly(ADP-ribose) polymerase 1 (PARP-1). Which disease is associated with this specific interacting partner? | microcephaly 21, primary, autosomal recessive | Medium | convergence | {"qa_id":"medium_convergence_03496","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and PRKN share multiple interacting partners. One such partner is described in a study reporting an interphase-specific interaction between condensin I... | |
medium_convergence_03497 | RPA3 and STX1A both interact with a shared protein. Evidence indicates that this shared protein forms a trans-SNARE complex with syntaxin1, a complex that excludes SNAP23, SNAP25, and SNAP29, and does not mediate membrane fusion. Which protein is encoded by the gene corresponding to this shared entity? | Vesicle-trafficking protein SEC22b | Medium | convergence | {"qa_id":"medium_convergence_03497","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RPA3 and STX1A both interact with a shared protein. Evidence indicates that this shared protein forms a trans-SNARE complex with syntaxin1, a complex that ex... | |
medium_convergence_03498 | CASP8 and FADD both interact with a specific protein that plays a role in the assembly of the death-inducing signaling complex (DISC). Evidence indicates that upon binding of a TNF superfamily ligand, DR5 homotrimerizes and recruits this protein, along with caspase-8, to form the DISC in plasma membrane lipid rafts. Wh... | basophil | Medium | convergence | {"qa_id":"medium_convergence_03498","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CASP8 and FADD both interact with a specific protein that plays a role in the assembly of the death-inducing signaling complex (DISC). Evidence indicates tha... | |
medium_convergence_03499 | The genes IL12B and VSIR are both associated with multiple shared biological processes. One specific shared process is linked to an entity described by the evidence: 'Inhibition of IL-23 and IL-12 was associated with increased IL-10 and decreased TNF-alpha production.' Which biological process, connected to that entity... | interleukin-10 production | Medium | convergence | {"qa_id":"medium_convergence_03499","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The genes IL12B and VSIR are both associated with multiple shared biological processes. One specific shared process is linked to an entity described by the e... | |
medium_convergence_03500 | Glimepiride and Diclofenac (ophthalmic) share a common interacting drug. Clinical evidence for the combination of Glimepiride and this shared drug reports a hazard ratio of 1.63 (95% CI: 1.29-2.06). Which disease is this shared drug indicated for? | inherited lipid metabolism disorder | Medium | convergence | {"qa_id":"medium_convergence_03500","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Glimepiride and Diclofenac (ophthalmic) share a common interacting drug. Clinical evidence for the combination of Glimepiride and this shared drug reports a ... | |
medium_convergence_03502 | YAP1 and ZNHIT1 share a common interacting partner. Experimental evidence indicates that this shared entity physically associates with YAP/TAZ in co-immunoprecipitation assays and disrupts the interaction between YAP and the β-TrCP E3 ubiquitin ligase, thereby promoting YAP protein degradation. Which disease is associa... | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03502","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and ZNHIT1 share a common interacting partner. Experimental evidence indicates that this shared entity physically associates with YAP/TAZ in co-immunopr... | |
medium_convergence_03503 | CYLD and IFIH1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Here, we show that Optineurin (Optn) dampens the antiviral innate immune response by targeting the deubiquitinating enzyme CYLD to this partner in order to inhibit its enzymatic activity.' Which ... | basophil | Medium | convergence | {"qa_id":"medium_convergence_03503","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CYLD and IFIH1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Here, we show that Optineurin (O... | |
medium_convergence_03505 | Human alphaherpesvirus 3 and Primate bocaparvovirus 1 are both reported to downregulate a specific host gene. Experimental data for this gene in a melanoma cell line (study GSE136586) shows a log2 fold change of -1.105 and an adjusted p-value of 4.346e-06. Which protein is encoded by this gene? | Mitochondrial import inner membrane translocase subunit Tim21 | Medium | convergence | {"qa_id":"medium_convergence_03505","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 3 and Primate bocaparvovirus 1 are both reported to downregulate a specific host gene. Experimental data for this gene in a melanoma c... | |
medium_convergence_03506 | Human mastadenovirus C and Primate bocaparvovirus 1 are both reported to downregulate a specific gene. Experimental data for this gene in lung fibroblast cell lines (study GSE120891) shows a log2 fold change of approximately -1.149 and an adjusted p-value of 0.03485. Which protein is encoded by this gene? | Centrin-2 | Medium | convergence | {"qa_id":"medium_convergence_03506","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human mastadenovirus C and Primate bocaparvovirus 1 are both reported to downregulate a specific gene. Experimental data for this gene in lung fibroblast cel... | |
medium_convergence_03508 | Enterovirus A and Rhinovirus A both downregulate a specific gene. Experimental data from a study on rhabdomyosarcoma cells (GSE103308) indicates that this gene has a log2 fold change of approximately -2.37 and an adjusted p-value of approximately 0.00093. Which protein is encoded by this gene? | High mobility group protein HMGI-C | Medium | convergence | {"qa_id":"medium_convergence_03508","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Enterovirus A and Rhinovirus A both downregulate a specific gene. Experimental data from a study on rhabdomyosarcoma cells (GSE103308) indicates that this ge... | |
medium_convergence_03509 | BRCA1 and UBA52 share multiple binding partners. One shared partner is implicated in a study stating: 'By using NMR spectroscopy and site-directed mutagenesis, we have mapped the binding site on the BARD1 heterodimer for the Ub-conjugating enzyme UbcH5c.' Which protein is encoded by the gene corresponding to this share... | Ubiquitin-conjugating enzyme E2 L3 | Medium | convergence | {"qa_id":"medium_convergence_03509","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRCA1 and UBA52 share multiple binding partners. One shared partner is implicated in a study stating: 'By using NMR spectroscopy and site-directed mutagenesi... | |
medium_convergence_03510 | CREBBP and ESR1 share multiple interacting partners. One such shared partner is supported by evidence stating: 'A physical interaction between a Kruppel-like family transcription factor and CBP was demonstrated by glutathione-S-transferase pull-down and by in vivo co-immuno-precipitation experiments.' Which protein is ... | Krueppel-like factor 4 | Medium | convergence | {"qa_id":"medium_convergence_03510","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and ESR1 share multiple interacting partners. One such shared partner is supported by evidence stating: 'A physical interaction between a Kruppel-like... | |
medium_convergence_03511 | YWHAQ and ESR1 share multiple interacting partners. One of these shared partners is characterized by the following evidence: 'Unlike AF-2, which binds signature NR boxes in the center of the p160 molecule, AF-1 binds to sequences near the p160 C terminus.' Which disease is associated with this specific shared partner v... | Fraser syndrome | Medium | convergence | {"qa_id":"medium_convergence_03511","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAQ and ESR1 share multiple interacting partners. One of these shared partners is characterized by the following evidence: 'Unlike AF-2, which binds signat... | |
medium_convergence_03513 | SIRT3 and PDHA1 share common interaction partners. One such shared partner is known to be directly interacted with and deacetylated by SIRT3 at lysine residue 228. Which protein is encoded by this specific shared partner? | Pyrroline-5-carboxylate reductase 1, mitochondrial | Medium | convergence | {"qa_id":"medium_convergence_03513","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIRT3 and PDHA1 share common interaction partners. One such shared partner is known to be directly interacted with and deacetylated by SIRT3 at lysine residu... | |
medium_convergence_03514 | CHMP1A and TSG101 both interact with a shared protein partner. Evidence regarding this partner indicates it is part of a complex that contains a fraction of total cellular TSG101 and also contains VPS37A but not VPS37C. Which protein is encoded by the gene corresponding to this shared partner? | Ubiquitin-associated protein 1 | Medium | convergence | {"qa_id":"medium_convergence_03514","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHMP1A and TSG101 both interact with a shared protein partner. Evidence regarding this partner indicates it is part of a complex that contains a fraction of ... | |
medium_convergence_03515 | GAB1 and NCK1 both interact with a shared protein entity. Experimental evidence indicates that ligand-activated, tyrosine-autophosphorylated platelet-derived growth factor or epidermal growth factor receptors were coimmunoprecipitated with anti-Nck antibodies, and this association was mediated by the SH2 domain of Nck.... | extrahepatic cholestasis | Medium | convergence | {"qa_id":"medium_convergence_03515","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GAB1 and NCK1 both interact with a shared protein entity. Experimental evidence indicates that ligand-activated, tyrosine-autophosphorylated platelet-derived... | |
medium_convergence_03516 | SMAD4 and PRKN (Parkin) share multiple interacting partners. One such shared partner is described in the following evidence: 'Here, we report that [protein encoded by UCHL1] is a novel interactor and substrate of PD-linked E3 ubiquitin-protein ligase parkin.' Which protein is encoded by the gene corresponding to this s... | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | Medium | convergence | {"qa_id":"medium_convergence_03516","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD4 and PRKN (Parkin) share multiple interacting partners. One such shared partner is described in the following evidence: 'Here, we report that [protein e... | |
medium_convergence_03517 | CASP8 and CARD11 each share a binding partner with another gene. Evidence concerning one of these shared partners states: 'Caspase 8 can interact with multiple proteins known to be involved in the activation of the NF-kappaB pathway, including the serine-threonine kinases RIP, NIK, IKK1 and a specific IKK subunit.' Whi... | Inhibitor of nuclear factor kappa-B kinase subunit beta | Medium | convergence | {"qa_id":"medium_convergence_03517","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CASP8 and CARD11 each share a binding partner with another gene. Evidence concerning one of these shared partners states: 'Caspase 8 can interact with multip... | |
medium_convergence_03518 | EP300 and NFIX both interact with a specific transcription factor. Evidence indicates that P300 and PCAF act as cofactors for this transcription factor, forming a complex on the miR200c/141 promoter. Which protein is encoded by this transcription factor? | Zinc finger E-box-binding homeobox 1 | Medium | convergence | {"qa_id":"medium_convergence_03518","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and NFIX both interact with a specific transcription factor. Evidence indicates that P300 and PCAF act as cofactors for this transcription factor, form... | |
medium_convergence_03519 | Theophylline and Cyproheptadine both interact with a specific shared drug. Evidence indicates that while p-Chlorophenylalanine and methergoline did not affect the anticonvulsive action of most benzodiazepines tested, this specific shared drug enhanced that action. Which disease is this shared drug indicated for? | anxiety | Medium | convergence | {"qa_id":"medium_convergence_03519","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Theophylline and Cyproheptadine both interact with a specific shared drug. Evidence indicates that while p-Chlorophenylalanine and methergoline did not affec... | |
medium_convergence_03520 | PARP1 and FANCD2 share multiple interacting partners. One such shared partner is described in evidence stating: 'We further showed that both hypo-H3K27me2/3 and H3.1K27M interacted with FANCD2, a central player in the choice of DNA repair pathway.' Which protein is encoded by the gene corresponding to this shared entit... | Histone H3.1 | Medium | convergence | {"qa_id":"medium_convergence_03520","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and FANCD2 share multiple interacting partners. One such shared partner is described in evidence stating: 'We further showed that both hypo-H3K27me2/3 ... | |
medium_convergence_03521 | IRAK1 and CD14 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here we show that, before IL-1beta treatment, this protein is present in a complex with IRAK, and that recruitment of this protein-IRAK complexes to the activated receptor complex occurs through association o... | asthma | Medium | convergence | {"qa_id":"medium_convergence_03521","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IRAK1 and CD14 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here we show that, before IL-1beta treatment,... | |
medium_convergence_03522 | DSC2 and DSG1 share a common binding partner. Experimental evidence from overlay assays indicates that PP1 binds to DP and Dsc1a, and to a lesser extent to desmoglein 1 (the shared partner), while PG binds to this shared partner and more weakly to Dsc1a and DP. Which disease is associated with this shared partner via a... | prostate cancer | Medium | convergence | {"qa_id":"medium_convergence_03522","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DSC2 and DSG1 share a common binding partner. Experimental evidence from overlay assays indicates that PP1 binds to DP and Dsc1a, and to a lesser extent to d... |
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