interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR002425 | 2,425 | Alcohol dehydrogenase, Drosophila-type | ADH_Drosophila-type | Family | 828 | false | false | null | [
"GO:0004022",
"GO:0006066"
] | [
"alcohol dehydrogenase (NAD+) activity",
"alcohol metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PRINTS"
] | [
"PR01168"
] | [
"ALCDHDRGNASE"
] | [
828
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"1.1.1.1",
"PWY-3162",
"PWY-5057",
"PWY-5076",
"PWY-5078",
"PWY-5079",
"PWY-5082",
"PWY-5480",
"PWY-5486",
"PWY-5751",
"PWY-6313",
"PWY-6333",
"PWY-6342",
"PWY-6587",
"PWY-6802",
"PWY-6871",
"PWY-7013",
"PWY-7111",
"PWY-7396"
] | [
"EC:1.1.1.1",
"METACYC:PWY-3162",
"METACYC:PWY-5057",
"METACYC:PWY-5076",
"METACYC:PWY-5078",
"METACYC:PWY-5079",
"METACYC:PWY-5082",
"METACYC:PWY-5480",
"METACYC:PWY-5486",
"METACYC:PWY-5751",
"METACYC:PWY-6313",
"METACYC:PWY-6333",
"METACYC:PWY-6342",
"METACYC:PWY-6587",
"METACYC:PWY-6... | 19 | [
"1a4u",
"1b14",
"1b15",
"1b16",
"1b2l",
"1mg5",
"1sby",
"3rj5",
"3rj9"
] | 9 | [
"PUB00000419",
"PUB00001371",
"PUB00001399",
"PUB00001408",
"PUB00004592",
"PUB00014249"
] | [
"7742302",
"2707261",
"1889416",
"1740120",
"6789320",
"9735295"
] | [
"Short-chain dehydrogenases/reductases (SDR).",
"The primary structure of alcohol dehydrogenase from Drosophila lebanonensis. Extensive variation within insect 'short-chain' alcohol dehydrogenase lacking zinc.",
"Characteristics of short-chain alcohol dehydrogenases and related enzymes.",
"cis-diol dehydrogen... | [
1995,
1989,
1991,
1992,
1981,
1998
] | 6 | [
"IPR002347"
] | [] | 1 | 0 | 1 | [
"Diptera"
] | [
828
] | 1 | [
"Drosophila melanogaster"
] | [
6
] | 1 | true | Family | Alcohol dehydrogenase, Drosophila-type | Alcohol dehydrogenase, Drosophila-type | ADH_Drosophila-type | 8 |
IPR002427 | 2,427 | Alcohol dehydrogenase-related | ADH-rel | Family | 80 | false | false | The short-chain dehydrogenases/reductases family (SDR) [ ] is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases. As the first member of this family to be characterised was Drosophila alcohol dehydrogenase, this family used to be called [ , , ] 'insect-type', or 'short-... | [
"GO:0016491"
] | [
"oxidoreductase activity"
] | [
"molecular_function"
] | 1 | [
"PRINTS"
] | [
"PR01170"
] | [
"ADHRELATED"
] | [
80
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-2142700",
"R-DME-9018676",
"R-DME-9018896"
] | [
"REACTOME:R-DME-2142700",
"REACTOME:R-DME-9018676",
"REACTOME:R-DME-9018896"
] | 3 | [] | 0 | [
"PUB00000419",
"PUB00001371",
"PUB00001399",
"PUB00001408",
"PUB00004592",
"PUB00014249"
] | [
"7742302",
"2707261",
"1889416",
"1740120",
"6789320",
"9735295"
] | [
"Short-chain dehydrogenases/reductases (SDR).",
"The primary structure of alcohol dehydrogenase from Drosophila lebanonensis. Extensive variation within insect 'short-chain' alcohol dehydrogenase lacking zinc.",
"Characteristics of short-chain alcohol dehydrogenases and related enzymes.",
"cis-diol dehydrogen... | [
1995,
1989,
1991,
1992,
1981,
1998
] | 6 | [
"IPR002347"
] | [] | 1 | 0 | 1 | [
"Schizophora"
] | [
80
] | 1 | [
"Drosophila melanogaster"
] | [
2
] | 1 | true | Family | Alcohol dehydrogenase-related | Alcohol dehydrogenase-related | ADH-rel | 5 |
IPR002429 | 2,429 | Cytochrome c oxidase subunit II-like C-terminal | CcO_II-like_C | Domain | 106,129 | false | false | Cytochrome c oxidase ( ) [ , ] is an oligomeric enzymatic complex which is a component of the respiratory chain and is involved in the transfer of electrons from cytochrome c to oxygen. In eukaryotes this enzyme complex is located in the mitochondrial inner membrane; in aerobic prokaryotes it is found in the plasma mem... | [
"GO:0004129",
"GO:0005507",
"GO:0016020"
] | [
"cytochrome-c oxidase activity",
"copper ion binding",
"membrane"
] | [
"molecular_function",
"molecular_function",
"cellular_component"
] | 3 | [
"PFAM",
"PROFILE"
] | [
"PF00116",
"PS50857"
] | [
"COX2",
"COX2_CUA"
] | [
100190,
105685
] | 2 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REA... | [
"7.1.1.9",
"PWY-3781",
"PWY-4521",
"PWY-6692",
"PWY-7279",
"PWY-7429",
"PWY-8271",
"PDOC00075",
"R-BTA-5419276",
"R-BTA-5628897",
"R-BTA-611105",
"R-BTA-9707564",
"R-BTA-9864848",
"R-CEL-5419276",
"R-DDI-9837999",
"R-DME-5419276",
"R-DME-5628897",
"R-DME-611105",
"R-DME-9707564",... | [
"EC:7.1.1.9",
"METACYC:PWY-3781",
"METACYC:PWY-4521",
"METACYC:PWY-6692",
"METACYC:PWY-7279",
"METACYC:PWY-7429",
"METACYC:PWY-8271",
"PROSITEDOC:PDOC00075",
"REACTOME:R-BTA-5419276",
"REACTOME:R-BTA-5628897",
"REACTOME:R-BTA-611105",
"REACTOME:R-BTA-9707564",
"REACTOME:R-BTA-9864848",
"RE... | 45 | [
"1ar1",
"1cyw",
"1cyx",
"1ehk",
"1fft",
"1fwx",
"1m56",
"1m57",
"1occ",
"1oco",
"1ocr",
"1ocz",
"1qle",
"1qni",
"1v54",
"1v55",
"1xme",
"2cua",
"2dyr",
"2dys",
"2eij",
"2eik",
"2eil",
"2eim",
"2ein",
"2fwl",
"2gsm",
"2iwf",
"2iwk",
"2lln",
"2occ",
"2qpd"... | 277 | [
"PUB00000581",
"PUB00001225",
"PUB00001426",
"PUB00002253",
"PUB00061601"
] | [
"6307356",
"1324168",
"1324835",
"8083153",
"9428682"
] | [
"Structure of cytochrome c oxidase.",
"Restoration of a lost metal-binding site: construction of two different copper sites into a subunit of the E. coli cytochrome o quinol oxidase complex.",
"Derived amino acid sequences of the nosZ gene (respiratory N2O reductase) from Alcaligenes eutrophus, Pseudomonas aeru... | [
1983,
1992,
1992,
1994,
1997
] | 5 | [] | [
"IPR034205",
"IPR034210",
"IPR034214",
"IPR034227",
"IPR034236"
] | 0 | 5 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1241,
32270,
71703,
915
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
6,
2,
2,
9,
1,
510,
3,
1,
3,
6,
1,
1,
6
] | 13 | true | Domain | Cytochrome c oxidase subunit II-like C-terminal | Cytochrome c oxidase subunit II-like C-terminal | CcO_II-like_C | 2 |
IPR002433 | 2,433 | Ornithine decarboxylase | Orn_de-COase | Family | 21,661 | false | false | null | [
"GO:0006596"
] | [
"polyamine biosynthetic process"
] | [
"biological_process"
] | 1 | [
"PRINTS",
"PANTHER"
] | [
"PR01182",
"PTHR11482"
] | [
"ORNDCRBXLASE",
""
] | [
17152,
19030
] | 2 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"... | [
"4.1.1.17",
"PWY-46",
"R-BTA-350562",
"R-BTA-351202",
"R-CEL-350562",
"R-CEL-351143",
"R-CEL-351202",
"R-DDI-351143",
"R-DDI-351202",
"R-DME-350562",
"R-DME-351143",
"R-DME-351202",
"R-HSA-350562",
"R-HSA-351143",
"R-HSA-351202",
"R-MMU-350562",
"R-MMU-351143",
"R-MMU-351202",
"R... | [
"EC:4.1.1.17",
"METACYC:PWY-46",
"REACTOME:R-BTA-350562",
"REACTOME:R-BTA-351202",
"REACTOME:R-CEL-350562",
"REACTOME:R-CEL-351143",
"REACTOME:R-CEL-351202",
"REACTOME:R-DDI-351143",
"REACTOME:R-DDI-351202",
"REACTOME:R-DME-350562",
"REACTOME:R-DME-351143",
"REACTOME:R-DME-351202",
"REACTOME... | 26 | [
"1d7k",
"1f3t",
"1njj",
"1qu4",
"1szr",
"2nv9",
"2nva",
"2on3",
"2oo0",
"2plj",
"2plk",
"2tod",
"3btn",
"4aib",
"4zgy",
"4zgz",
"5bwa",
"5gjm",
"5gjn",
"5gjo",
"5gjp",
"6knh",
"6kni",
"6knk",
"7odc",
"7s3f",
"7s3g",
"7u6p",
"7u6u",
"9b8m",
"9b8n",
"9fos"... | 34 | [
"PUB00001452",
"PUB00002116",
"PUB00002726",
"PUB00003632",
"PUB00089255",
"PUB00092857",
"PUB00100359",
"PUB00100377"
] | [
"8181483",
"2198270",
"1730582",
"3143046",
"8631929",
"19775248",
"31885262",
"15654104"
] | [
"Multiple evolutionary origin of pyridoxal-5'-phosphate-dependent amino acid decarboxylases.",
"Nucleotide sequence and analysis of the speA gene encoding biosynthetic arginine decarboxylase in Escherichia coli.",
"Mechanism of the irreversible inactivation of mouse ornithine decarboxylase by alpha-difluorometh... | [
1994,
1990,
1992,
1988,
1996,
2009,
2020,
2005
] | 8 | [
"IPR000183"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
52,
8277,
13174,
20,
138
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
... | [
2,
8,
3,
15,
14,
1,
12,
15,
1,
1,
8
] | 11 | true | Family | Ornithine decarboxylase | Ornithine decarboxylase | Orn_de-COase | 7 |
IPR002434 | 2,434 | Sodium:neurotransmitter symporter, taurine | Na/ntran_symport_taurine | Family | 1,607 | false | false | Neurotransmitter transport systems are integral to the release, re-uptake and recycling of neurotransmitters at synapses. High affinity transport proteins found in the plasma membrane of presynaptic nerve terminals and glial cells are responsible for the removal from the extracellular space of released-transmitters, th... | [
"GO:0005369",
"GO:0006836",
"GO:0005886",
"GO:0016020"
] | [
"taurine:sodium symporter activity",
"neurotransmitter transport",
"plasma membrane",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component",
"cellular_component"
] | 4 | [
"PRINTS",
"CDD"
] | [
"PR01200",
"cd11510"
] | [
"TAUTRANSPORT",
"SLC6sbd_TauT"
] | [
1487,
1172
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-352230",
"R-HSA-442660",
"R-MMU-352230",
"R-MMU-442660",
"R-RNO-352230",
"R-RNO-442660"
] | [
"REACTOME:R-HSA-352230",
"REACTOME:R-HSA-442660",
"REACTOME:R-MMU-352230",
"REACTOME:R-MMU-442660",
"REACTOME:R-RNO-352230",
"REACTOME:R-RNO-442660"
] | 6 | [
"9j7m",
"9j7n",
"9j7o",
"9jcv",
"9jcz",
"9jd3",
"9jd4",
"9jd5",
"9jd6",
"9jd9",
"9jda",
"9jdg",
"9jdj",
"9jdl",
"9jg4",
"9jg5",
"9jln",
"9k0c",
"9k0n",
"9k0o",
"9k1b",
"9k1f",
"9k1h",
"9k1i",
"9k1v",
"9k1x",
"9k1z",
"9k21",
"9k7b",
"9k7n",
"9kmi",
"9kmj"... | 36 | [
"PUB00001020",
"PUB00006006",
"PUB00006007",
"PUB00006008",
"PUB00006013",
"PUB00006036"
] | [
"15336049",
"8811182",
"8103691",
"7823024",
"1365830",
"1518851"
] | [
"Cloners quick on the uptake.",
"Molecular biology of mammalian amino acid transporters.",
"Neurotransmitter transporters: three distinct gene families.",
"Neurotransmitter transporters: three important gene families for neuronal function.",
"Osmolytes.",
"Molecular cloning of the cDNA for an MDCK cell Na... | [
1992,
1996,
1993,
1994,
1992,
1992
] | 6 | [
"IPR000175"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
1607
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
5,
3,
4
] | 4 | true | Family | Sodium:neurotransmitter symporter, taurine | Sodium:neurotransmitter symporter, taurine | Na/ntran_symport_taurine | 5 |
IPR002435 | 2,435 | Sodium:neurotransmitter symporter, noradrenaline | Na/ntran_symport_noradrenaline | Family | 707 | false | false | Neurotransmitter transport systems are integral to the release, re-uptake and recycling of neurotransmitters at synapses. High affinity transport proteins found in the plasma membrane of presynaptic nerve terminals and glial cells are responsible for the removal from the extracellular space of released-transmitters, th... | [
"GO:0005328",
"GO:0006836",
"GO:0005886",
"GO:0016020"
] | [
"neurotransmitter:sodium symporter activity",
"neurotransmitter transport",
"plasma membrane",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component",
"cellular_component"
] | 4 | [
"PRINTS"
] | [
"PR01201"
] | [
"NORTRANSPORT"
] | [
707
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-442660",
"R-HSA-5619109",
"R-MMU-442660"
] | [
"REACTOME:R-HSA-442660",
"REACTOME:R-HSA-5619109",
"REACTOME:R-MMU-442660"
] | 3 | [
"8hfe",
"8hff",
"8hfg",
"8hfi",
"8hfl",
"8i3v",
"8wgr",
"8wgx",
"8wtu",
"8wtv",
"8wtw",
"8wtx",
"8wty",
"8y8z",
"8y90",
"8y91",
"8y92",
"8y93",
"8y94",
"8y95",
"8yr2",
"8z1l",
"8zoy",
"8zp1",
"8zp2",
"8zpb",
"9kda"
] | 27 | [
"PUB00001020",
"PUB00006006",
"PUB00006007",
"PUB00006008",
"PUB00006037",
"PUB00006038",
"PUB00006039",
"PUB00100488",
"PUB00100489",
"PUB00100490"
] | [
"15336049",
"8811182",
"8103691",
"7823024",
"2008212",
"8478011",
"9480909",
"34445205",
"33340618",
"32339102"
] | [
"Cloners quick on the uptake.",
"Molecular biology of mammalian amino acid transporters.",
"Neurotransmitter transporters: three distinct gene families.",
"Neurotransmitter transporters: three important gene families for neuronal function.",
"Expression cloning of a cocaine- and antidepressant-sensitive hum... | [
1992,
1996,
1993,
1994,
1991,
1993,
1998,
2021,
2021,
2020
] | 10 | [
"IPR000175"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
707
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
4,
7
] | 3 | true | Family | Sodium:neurotransmitter symporter, noradrenaline | Sodium:neurotransmitter symporter, noradrenaline | Na/ntran_symport_noradrenaline | 3 |
IPR002436 | 2,436 | Sodium:neurotransmitter symporter, dopamine | Na/ntran_symport_dopamine | Family | 352 | false | false | Neurotransmitter transport systems are integral to the release, re-uptake and recycling of neurotransmitters at synapses. High affinity transport proteins found in the plasma membrane of presynaptic nerve terminals and glial cells are responsible for the removal from the extracellular space of released-transmitters, th... | [
"GO:0005330",
"GO:0006836",
"GO:0005886",
"GO:0016020"
] | [
"dopamine:sodium symporter activity",
"neurotransmitter transport",
"plasma membrane",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component",
"cellular_component"
] | 4 | [
"PRINTS"
] | [
"PR01202"
] | [
"DOPTRANSPORT"
] | [
352
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-379401",
"R-HSA-442660",
"R-HSA-5619081",
"R-HSA-5660724",
"R-MMU-379401",
"R-MMU-442660",
"R-RNO-379401",
"R-RNO-442660"
] | [
"REACTOME:R-HSA-379401",
"REACTOME:R-HSA-442660",
"REACTOME:R-HSA-5619081",
"REACTOME:R-HSA-5660724",
"REACTOME:R-MMU-379401",
"REACTOME:R-MMU-442660",
"REACTOME:R-RNO-379401",
"REACTOME:R-RNO-442660"
] | 8 | [
"9eo4"
] | 1 | [
"PUB00001020",
"PUB00006006",
"PUB00006007",
"PUB00006008",
"PUB00006040",
"PUB00006041"
] | [
"15336049",
"8811182",
"8103691",
"7823024",
"1406597",
"10435196"
] | [
"Cloners quick on the uptake.",
"Molecular biology of mammalian amino acid transporters.",
"Neurotransmitter transporters: three distinct gene families.",
"Neurotransmitter transporters: three important gene families for neuronal function.",
"Cloning, pharmacological characterization, and chromosome assignm... | [
1992,
1996,
1993,
1994,
1992,
1999
] | 6 | [
"IPR000175"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
352
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
5,
2
] | 3 | true | Family | Sodium:neurotransmitter symporter, dopamine | Sodium:neurotransmitter symporter, dopamine | Na/ntran_symport_dopamine | 7 |
IPR002438 | 2,438 | Neutral amino acid SLC6 transporter | Neutral_aa_SLC6 | Family | 4,502 | false | false | Solute carrier 6 (SLC6) transporters are part of the neurotransmitter:sodium symporters family. This entry represents a group of neutral amino acid SLC6 transporters that includes B0AT1 (SLC6A19), B0AT3 (SLC6A18), B0AT2 (SLC6A15), NTT4/XT1 (SLC6A17) and XTRP3/XT3 (SLC6A20) [ ]. B0AT1 (SLC6A19) catalyzes the secondary a... | [
"GO:0005886"
] | [
"plasma membrane"
] | [
"cellular_component"
] | 1 | [
"PRINTS"
] | [
"PR01206"
] | [
"ORPHTRNSPORT"
] | [
4502
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-352230",
"R-BTA-442660",
"R-HSA-352230",
"R-HSA-442660",
"R-HSA-5619044",
"R-HSA-5619079",
"R-HSA-5619101",
"R-HSA-5659729",
"R-HSA-5659735",
"R-HSA-5660686",
"R-MMU-352230",
"R-MMU-442660",
"R-RNO-352230",
"R-RNO-442660"
] | [
"REACTOME:R-BTA-352230",
"REACTOME:R-BTA-442660",
"REACTOME:R-HSA-352230",
"REACTOME:R-HSA-442660",
"REACTOME:R-HSA-5619044",
"REACTOME:R-HSA-5619079",
"REACTOME:R-HSA-5619101",
"REACTOME:R-HSA-5659729",
"REACTOME:R-HSA-5659735",
"REACTOME:R-HSA-5660686",
"REACTOME:R-MMU-352230",
"REACTOME:R-M... | 14 | [
"6m17",
"6m18",
"6m1d",
"7dwx",
"7v61",
"7y75",
"7y76",
"8i91",
"8i92",
"8i93",
"8p2w",
"8p2x",
"8p2y",
"8p2z",
"8p30",
"8p31",
"8wby",
"8wbz",
"8wm3"
] | 19 | [
"PUB00091349",
"PUB00091350",
"PUB00091351"
] | [
"23506866",
"26240152",
"23876153"
] | [
"SLC6 transporters: structure, function, regulation, disease association and therapeutics.",
"Molecular basis for the interaction of the mammalian amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin.",
"Diseases associated with general amino acid transporters of the solute carrier 6 ... | [
2013,
2015,
2013
] | 3 | [
"IPR000175"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
4502
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
14,
15,
26
] | 4 | true | Family | Neutral amino acid SLC6 transporter | Neutral amino acid SLC6 transporter | Neutral_aa_SLC6 | 7 |
IPR002439 | 2,439 | Glucose transporter, type 1 (GLUT1) | Glu_transpt_1 | Family | 697 | false | false | Facilitative sugar transport is mediated by members of the GLUT transporter family, which form an aqueous pore across the membrane through which sugars can move in a passive (i.e., energy-independent) manner. The GLUT family of glycosylated transmembrane proteins are predicted to span the membrane 12 times with both am... | [
"GO:0055056",
"GO:1904659",
"GO:0016020"
] | [
"D-glucose transmembrane transporter activity",
"D-glucose transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01190"
] | [
"GLUCTRSPORT1"
] | [
697
] | 1 | [
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"GenProp2089",
"GenProp2099",
"R-BTA-189200",
"R-BTA-196836",
"R-BTA-422356",
"R-BTA-5653890",
"R-GGA-352832",
"R-HSA-189200",
"R-HSA-196836",
"R-HSA-422356",
"R-HSA-5619043",
"R-HSA-5653890",
"R-MMU-189200",
"R-MMU-196836",
"R-MMU-422356",
"R-MMU-5653890",
"R-RNO-189200",
"R-RNO-1... | [
"GP:GenProp2089",
"GP:GenProp2099",
"REACTOME:R-BTA-189200",
"REACTOME:R-BTA-196836",
"REACTOME:R-BTA-422356",
"REACTOME:R-BTA-5653890",
"REACTOME:R-GGA-352832",
"REACTOME:R-HSA-189200",
"REACTOME:R-HSA-196836",
"REACTOME:R-HSA-422356",
"REACTOME:R-HSA-5619043",
"REACTOME:R-HSA-5653890",
"RE... | 24 | [
"4pyp",
"5eqg",
"5eqh",
"5eqi",
"6tha"
] | 5 | [
"PUB00002464",
"PUB00005096",
"PUB00005353",
"PUB00006044",
"PUB00006047"
] | [
"3170580",
"3839598",
"2180146",
"8366068",
"9841639"
] | [
"Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues.",
"Sequence and structure of a human glucose transporter.",
"Facilitative glucose transporters: an expanding family.",
"Structure and function of... | [
1988,
1985,
1990,
1993,
1998
] | 5 | [
"IPR045263"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
697
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
3
] | 3 | true | Family | Glucose transporter, type 1 (GLUT1) | Glucose transporter, type 1 (GLUT1) | Glu_transpt_1 | 3 |
IPR002440 | 2,440 | Glucose transporter, type 2 (GLUT2) | Glc_transpt_2 | Family | 295 | false | false | The ability to transport glucose across the plasma membrane is a feature common to nearly all cells, from simple bacteria through to highly specialised mammalian neurones. Facilitative sugar transport is mediated by members of the GLUT transporter family, which form an aqueous pore across the membrane through which sug... | [
"GO:0055056",
"GO:1904659",
"GO:0016020"
] | [
"D-glucose transmembrane transporter activity",
"D-glucose transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01191"
] | [
"GLUCTRSPORT2"
] | [
295
] | 1 | [
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"GenProp2089",
"GenProp2099",
"R-BTA-189200",
"R-BTA-422356",
"R-BTA-8981373",
"R-GGA-352832",
"R-HSA-189200",
"R-HSA-210745",
"R-HSA-422356",
"R-HSA-5619098",
"R-HSA-8981373",
"R-MMU-189200",
"R-MMU-422356",
"R-MMU-8981373",
"R-RNO-189200",
"R-RNO-422356",
"R-RNO-8981373",
"R-SSC-... | [
"GP:GenProp2089",
"GP:GenProp2099",
"REACTOME:R-BTA-189200",
"REACTOME:R-BTA-422356",
"REACTOME:R-BTA-8981373",
"REACTOME:R-GGA-352832",
"REACTOME:R-HSA-189200",
"REACTOME:R-HSA-210745",
"REACTOME:R-HSA-422356",
"REACTOME:R-HSA-5619098",
"REACTOME:R-HSA-8981373",
"REACTOME:R-MMU-189200",
"RE... | 20 | [] | 0 | [
"PUB00002464",
"PUB00003999",
"PUB00005096",
"PUB00005353",
"PUB00005398",
"PUB00006044",
"PUB00006047",
"PUB00006048"
] | [
"3170580",
"3543693",
"3839598",
"2180146",
"8438231",
"8366068",
"9841639",
"2446136"
] | [
"Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues.",
"Mammalian and bacterial sugar transport proteins are homologous.",
"Sequence and structure of a human glucose transporter.",
"Facilitative glu... | [
1988,
1987,
1985,
1990,
1993,
1993,
1998,
1987
] | 8 | [
"IPR045263"
] | [] | 1 | 0 | 1 | [
"Amniota"
] | [
295
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
6
] | 3 | true | Family | Glucose transporter, type 2 (GLUT2) | Glucose transporter, type 2 (GLUT2) | Glc_transpt_2 | 1 |
IPR002441 | 2,441 | Glucose transporter, type 4 (GLUT4) | Glc_transpt_4 | Family | 391 | false | false | The ability to transport glucose across the plasma membrane is a feature common to nearly all cells, from simple bacteria through to highly specialised mammalian neurones. Facilitative sugar transport is mediated by members of the GLUT transporter family, which form an aqueous pore across the membrane through which sug... | [
"GO:0055056",
"GO:0032869",
"GO:1904659",
"GO:0016020"
] | [
"D-glucose transmembrane transporter activity",
"cellular response to insulin stimulus",
"D-glucose transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PRINTS"
] | [
"PR01193"
] | [
"GLUCTRSPORT4"
] | [
391
] | 1 | [
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"GenProp2090",
"R-BTA-189200",
"R-HSA-1445148",
"R-HSA-189200",
"R-HSA-381340",
"R-MMU-189200",
"R-RNO-189200"
] | [
"GP:GenProp2090",
"REACTOME:R-BTA-189200",
"REACTOME:R-HSA-1445148",
"REACTOME:R-HSA-189200",
"REACTOME:R-HSA-381340",
"REACTOME:R-MMU-189200",
"REACTOME:R-RNO-189200"
] | 7 | [
"7wsm",
"7wsn"
] | 2 | [
"PUB00002464",
"PUB00003999",
"PUB00005096",
"PUB00005353",
"PUB00005398",
"PUB00006044",
"PUB00006047",
"PUB00006048",
"PUB00035751"
] | [
"3170580",
"3543693",
"3839598",
"2180146",
"8438231",
"8366068",
"9841639",
"2446136",
"11994746"
] | [
"Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues.",
"Mammalian and bacterial sugar transport proteins are homologous.",
"Sequence and structure of a human glucose transporter.",
"Facilitative glu... | [
1988,
1987,
1985,
1990,
1993,
1993,
1998,
1987,
2002
] | 9 | [
"IPR045263"
] | [] | 1 | 0 | 1 | [
"Tetrapoda"
] | [
391
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
3,
6
] | 3 | true | Family | Glucose transporter, type 4 (GLUT4) | Glucose transporter, type 4 (GLUT4) | Glc_transpt_4 | 4 |
IPR002442 | 2,442 | Fructose transporter, type 5 (GLUT5) | Fru_transpt_5 | Family | 286 | false | false | The ability to transport glucose across the plasma membrane is a feature common to nearly all cells, from simple bacteria through to highly specialised mammalian neurones. Facilitative sugar transport is mediated by members of the GLUT transporter family, which form an aqueous pore across the membrane through which sug... | [
"GO:0005353",
"GO:0015755",
"GO:0016020"
] | [
"fructose transmembrane transporter activity",
"fructose transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01194"
] | [
"GLUCTRSPORT5"
] | [
286
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-6798695",
"R-BTA-8981373",
"R-HSA-6798695",
"R-HSA-8981373",
"R-MMU-6798695",
"R-MMU-8981373",
"R-RNO-6798695",
"R-RNO-8981373"
] | [
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-8981373",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-8981373",
"REACTOME:R-MMU-6798695",
"REACTOME:R-MMU-8981373",
"REACTOME:R-RNO-6798695",
"REACTOME:R-RNO-8981373"
] | 8 | [
"4ybq"
] | 1 | [
"PUB00002464",
"PUB00003999",
"PUB00005096",
"PUB00005353",
"PUB00005398",
"PUB00006044",
"PUB00006047",
"PUB00006048",
"PUB00006151"
] | [
"3170580",
"3543693",
"3839598",
"2180146",
"8438231",
"8366068",
"9841639",
"2446136",
"1634504"
] | [
"Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues.",
"Mammalian and bacterial sugar transport proteins are homologous.",
"Sequence and structure of a human glucose transporter.",
"Facilitative glu... | [
1988,
1987,
1985,
1990,
1993,
1993,
1998,
1987,
1992
] | 9 | [
"IPR045263"
] | [] | 1 | 0 | 1 | [
"Amniota"
] | [
286
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
10,
2,
7
] | 3 | true | Family | Fructose transporter, type 5 (GLUT5) | Fructose transporter, type 5 (GLUT5) | Fru_transpt_5 | 4 |
IPR002443 | 2,443 | Solute carrier family 12 member 1/2 | SLC12A1/SLC12A2 | Family | 3,889 | false | false | The Na-K-Cl co-transporters are a family of integral membrane proteins that are ubiquitously expressed in animal tissues, serving a variety of functions. In cells of Cl - absorptive and Cl - secretory epithelia, Na-K-Cl co-transport serves as the major Cl - entry pathway, and functions in concert with other membrane io... | [
"GO:0022857",
"GO:0006811",
"GO:0016020"
] | [
"transmembrane transporter activity",
"monoatomic ion transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01207"
] | [
"NAKCLTRNSPRT"
] | [
3889
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-426117",
"R-HSA-426117",
"R-HSA-5619104",
"R-MMU-426117",
"R-RNO-426117"
] | [
"REACTOME:R-DRE-426117",
"REACTOME:R-HSA-426117",
"REACTOME:R-HSA-5619104",
"REACTOME:R-MMU-426117",
"REACTOME:R-RNO-426117"
] | 5 | [
"6nph",
"6npk",
"6npl",
"6pzt",
"7d10",
"7mxo",
"7n3n",
"7s1x",
"7s1y",
"7s1z",
"7sfl",
"7smp",
"7zgo",
"9c0e",
"9c0g",
"9c0h"
] | 16 | [
"PUB00006049",
"PUB00006050",
"PUB00100496"
] | [
"7495568",
"9719864",
"32081947"
] | [
"Molecular characterization of the epithelial Na-K-Cl cotransporter isoforms.",
"Mutations in Na(K)Cl transporters in Gitelman's and Bartter's syndromes.",
"Structure of the human cation-chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy."
] | [
1995,
1998,
2020
] | 3 | [
"IPR004842"
] | [
"IPR002444",
"IPR002445"
] | 1 | 2 | 0 | [
"Eumetazoa"
] | [
3889
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
3,
11,
6,
18
] | 5 | true | Family | Solute carrier family 12 member 1/2 | Solute carrier family 12 member 1/2 | SLC12A1/SLC12A2 | 3 |
IPR002444 | 2,444 | Solute carrier family 12 member 2 | NKCC1 | Family | 1,791 | false | false | The K+Cl- cotransporters (KCCs) constitute a branch of the electroneutral cation-coupled chloride cotransporter family SLC12 (Solute carrier family 12). The other branch of the SLC12 family is composed of the Na+-coupled chloride cotransporters, generally called N(K)CCs, that following the driving force imposed by the ... | [
"GO:0022857",
"GO:0006811",
"GO:0016020"
] | [
"transmembrane transporter activity",
"monoatomic ion transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01208"
] | [
"NAKCLTRSPRT1"
] | [
1791
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-426117",
"R-HSA-426117",
"R-MMU-426117"
] | [
"REACTOME:R-DRE-426117",
"REACTOME:R-HSA-426117",
"REACTOME:R-MMU-426117"
] | 3 | [
"6pzt",
"7d10",
"7mxo",
"7n3n",
"7s1x",
"7s1y",
"7s1z",
"7sfl",
"7smp",
"7zgo",
"8ste",
"9c0e",
"9c0g",
"9c0h"
] | 14 | [
"PUB00006049",
"PUB00006050",
"PUB00006051",
"PUB00006052",
"PUB00006053",
"PUB00072371",
"PUB00100496"
] | [
"7495568",
"9719864",
"8134373",
"7629105",
"7929272",
"15788703",
"32081947"
] | [
"Molecular characterization of the epithelial Na-K-Cl cotransporter isoforms.",
"Mutations in Na(K)Cl transporters in Gitelman's and Bartter's syndromes.",
"Molecular cloning and functional expression of the bumetanide-sensitive Na-K-Cl cotransporter.",
"Primary structure, functional expression, and chromosom... | [
1995,
1998,
1994,
1995,
1994,
2005,
2020
] | 7 | [
"IPR002443"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
1791
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
4,
3,
4
] | 4 | true | Family | Solute carrier family 12 member 2 | Solute carrier family 12 member 2 | NKCC1 | 4 |
IPR002445 | 2,445 | Solute carrier family 12 member 1 | Slc12a1 | Family | 1,013 | false | false | Solute carrier family 12 member 1 (SLC12A1 or NKCC2) is an apical absorptive Na-K-Cl co-transporter isoform. In contrast to the wide tissue distribution of NKCC1, expression of the NKCC2 isoform is restricted to the vertebrate kidney, where it is involved in urinary concentration [ ]. Subsequent studies revealed that t... | [
"GO:0022857",
"GO:0006811",
"GO:0016020"
] | [
"transmembrane transporter activity",
"monoatomic ion transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01209"
] | [
"NAKCLTRSPRT2"
] | [
1013
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-426117",
"R-HSA-5619104",
"R-MMU-426117",
"R-RNO-426117"
] | [
"REACTOME:R-HSA-426117",
"REACTOME:R-HSA-5619104",
"REACTOME:R-MMU-426117",
"REACTOME:R-RNO-426117"
] | 4 | [] | 0 | [
"PUB00006049",
"PUB00006050",
"PUB00006054",
"PUB00006055"
] | [
"7495568",
"9719864",
"7514306",
"8021284"
] | [
"Molecular characterization of the epithelial Na-K-Cl cotransporter isoforms.",
"Mutations in Na(K)Cl transporters in Gitelman's and Bartter's syndromes.",
"Alternatively spliced isoforms of the putative renal Na-K-Cl cotransporter are differentially distributed within the rabbit kidney.",
"Molecular cloning,... | [
1995,
1998,
1994,
1994
] | 4 | [
"IPR002443"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
1013
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
4,
13
] | 3 | true | Family | Solute carrier family 12 member 1 | Solute carrier family 12 member 1 | Slc12a1 | 5 |
IPR002446 | 2,446 | Lipocalin, bacterial | Lipocalin_bac | Family | 8,424 | false | false | null | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR01171"
] | [
"BCTLIPOCALIN"
] | [
8424
] | 1 | [] | [] | [] | 0 | [
"1qwd",
"2aco",
"3mbt",
"6ubo",
"6ukk",
"6ukl",
"6vri",
"7l5k",
"7l5l",
"7l5m",
"8wb2"
] | 11 | [
"PUB00000545",
"PUB00002920",
"PUB00003448",
"PUB00005094",
"PUB00006128",
"PUB00006133",
"PUB00014135"
] | [
"8761444",
"7559452",
"8573354",
"2580349",
"8571450",
"9202455",
"11058749"
] | [
"The lipocalin protein family: structure and function.",
"Stationary phase expression of a novel Escherichia coli outer membrane lipoprotein and its relationship with mammalian apolipoprotein D. Implications for the origin of lipocalins.",
"Multiple molecular recognition properties of the lipocalin protein fami... | [
1996,
1995,
1995,
1985,
1995,
1997,
2000
] | 7 | [
"IPR022271"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
7571,
779,
19,
55
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
3,
1,
2,
2
] | 4 | true | Family | Lipocalin, bacterial | Lipocalin, bacterial | Lipocalin_bac | 4 |
IPR002447 | 2,447 | Beta-lactoglobulin | Blactoglobulin | Family | 354 | false | false | Beta-lactoglobulin (Blg) is the major protein component of milk from a wide range of species but not human. Glycodelin or PP14 protein is the human equivalent of Blg and is secreted into the endometrium. Blg binds a wide variety of hydrophobic ligands but its function remains unknown. The crystal structure of Blg has b... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR01172"
] | [
"BLCTOGLOBULN"
] | [
354
] | 1 | [] | [] | [] | 0 | [
"1b0o",
"1b8e",
"1beb",
"1bso",
"1bsq",
"1bsy",
"1cj5",
"1dv9",
"1exs",
"1gx8",
"1gx9",
"1gxa",
"1qg5",
"1uz2",
"1yup",
"2akq",
"2blg",
"2gj5",
"2q2m",
"2q2p",
"2q39",
"2r56",
"3blg",
"3kza",
"3npo",
"3nq3",
"3nq9",
"3ph5",
"3ph6",
"3ueu",
"3uev",
"3uew"... | 115 | [
"PUB00000545",
"PUB00003448",
"PUB00005094",
"PUB00006131",
"PUB00087244",
"PUB00087245",
"PUB00087246",
"PUB00087247",
"PUB00087248"
] | [
"8761444",
"8573354",
"2580349",
"9115437",
"9918684",
"7531163",
"17192260",
"12672671",
"15883155"
] | [
"The lipocalin protein family: structure and function.",
"Multiple molecular recognition properties of the lipocalin protein family.",
"Homology of beta-lactoglobulin, serum retinol-binding protein, and protein HC.",
"Bovine beta-lactoglobulin at 1.8 A resolution--still an enigmatic lipocalin.",
"Placental ... | [
1996,
1995,
1985,
1997,
1999,
1995,
2007,
2003,
2005
] | 9 | [
"IPR002345"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
354
] | 1 | [
"Homo sapiens"
] | [
8
] | 1 | true | Family | Beta-lactoglobulin | Beta-lactoglobulin | Blactoglobulin | 6 |
IPR002448 | 2,448 | Lipocalin, OBP-like | OBP-like | Family | 481 | false | false | The crystal structures of several lipocalins have been solved and show a novel 8-stranded anti-parallel β-barrel fold well conserved within the family. Sequence similarity within the family is at a much lower level and would seem to be restricted to conserved disulphides and 3 motifs, which form a juxtaposed cluster th... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR01173"
] | [
"ODORANTBNDNG"
] | [
481
] | 1 | [] | [] | [] | 0 | [
"1a3y",
"1bj7",
"1dzj",
"1dzk",
"1dzm",
"1dzp",
"1e00",
"1e02",
"1e06",
"1e5p",
"1g85",
"1gt1",
"1gt3",
"1gt4",
"1gt5",
"1hn2",
"1hqp",
"1obp",
"1pbo",
"2hlv",
"3fiq",
"4odd",
"4wfu",
"4wfv",
"8a0d"
] | 25 | [
"PUB00000545",
"PUB00003448",
"PUB00006118",
"PUB00006138",
"PUB00006139",
"PUB00006141",
"PUB00087197"
] | [
"8761444",
"8573354",
"8170479",
"9867863",
"9891000",
"9929622",
"20085627"
] | [
"The lipocalin protein family: structure and function.",
"Multiple molecular recognition properties of the lipocalin protein family.",
"The rat probasin gene promoter directs hormonally and developmentally regulated expression of a heterologous gene specifically to the prostate in transgenic mice.",
"The gold... | [
1996,
1995,
1994,
1999,
1999,
1998,
2010
] | 7 | [
"IPR002345"
] | [] | 1 | 0 | 1 | [
"Opisthokonta"
] | [
481
] | 1 | [
"Mus musculus",
"Rattus norvegicus"
] | [
9,
11
] | 2 | true | Family | Lipocalin, OBP-like | Lipocalin, OBP-like | OBP-like | 3 |
IPR002449 | 2,449 | Retinol binding protein/Purpurin | Retinol-bd/Purpurin | Family | 2,050 | false | false | Proteins in this family include plasma retinol binding protein (pRBP) and purpurin. They mediate retinol transport in blood plasma [ ]. Binding to RBP allows the hydrophobic vitamin to circulate in blood, but retinol dissociates from the protein prior to entering target cells [ ]. Retinol circulates in the plasma witho... | [
"GO:0005501",
"GO:0034632"
] | [
"retinoid binding",
"retinol transmembrane transporter activity"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PIRSF",
"PRINTS",
"PANTHER"
] | [
"PIRSF500204",
"PR01174",
"PTHR11873"
] | [
"RBP_purpurin",
"RETINOLBNDNG",
""
] | [
1375,
1858,
2006
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-GGA-2453902",
"R-GGA-975634",
"R-HSA-2453902",
"R-HSA-6809583",
"R-HSA-975634",
"R-HSA-9918449",
"R-MMU-2453902",
"R-MMU-975634",
"R-RNO-2453902",
"R-RNO-975634"
] | [
"REACTOME:R-GGA-2453902",
"REACTOME:R-GGA-975634",
"REACTOME:R-HSA-2453902",
"REACTOME:R-HSA-6809583",
"REACTOME:R-HSA-975634",
"REACTOME:R-HSA-9918449",
"REACTOME:R-MMU-2453902",
"REACTOME:R-MMU-975634",
"REACTOME:R-RNO-2453902",
"REACTOME:R-RNO-975634"
] | 10 | [
"1aqb",
"1brp",
"1brq",
"1erb",
"1fel",
"1fem",
"1fen",
"1hbp",
"1hbq",
"1iiu",
"1jyd",
"1jyj",
"1kt3",
"1kt4",
"1kt5",
"1kt6",
"1kt7",
"1qab",
"1rbp",
"1rlb",
"2wq9",
"2wqa",
"2wr6",
"3bsz",
"3fmz",
"4o9s",
"4psq",
"5nty",
"5nu2",
"5nu6",
"5nu7",
"5nu8"... | 36 | [
"PUB00027812",
"PUB00027816",
"PUB00027826",
"PUB00027851",
"PUB00027869",
"PUB00027928",
"PUB00027929",
"PUB00027972",
"PUB00087235",
"PUB00087236"
] | [
"3754874",
"6682115",
"1740159",
"2993313",
"11278316",
"6369133",
"3652208",
"5675424",
"5541771",
"22665496"
] | [
"A chick neural retina adhesion and survival molecule is a retinol-binding protein.",
"Ligand-dependent regulation of intracellular protein transport: effect of vitamin a on the secretion of the retinol-binding protein.",
"The piscine plasma retinol-binding protein. Purification, partial amino acid sequence and... | [
1986,
1983,
1992,
1985,
2001,
1984,
1987,
1968,
1971,
2012
] | 10 | [
"IPR022271"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
2050
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
2,
5,
6
] | 5 | true | Family | Retinol binding protein/Purpurin | Retinol binding protein/Purpurin | Retinol-bd/Purpurin | 2 |
IPR002450 | 2,450 | von Ebner's gland protein/ Bos/Can allergen | von_Ebner_gland | Family | 487 | false | false | Von Ebner's gland protein (VEGP), a protein highly expressed by the small acinar von Ebner's salivary glands of the tongue, but not in the secretory duct, undertakes the selective binding of sapid chemicals and their transport to taste receptors [ ] in salivary secretions. VEGP can help to clear the bitter-tasting comp... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR01175"
] | [
"VNEBNERGLAND"
] | [
487
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-804914",
"R-RNO-804914",
"R-SSC-804914"
] | [
"REACTOME:R-HSA-804914",
"REACTOME:R-RNO-804914",
"REACTOME:R-SSC-804914"
] | 3 | [
"1xki",
"3eyc",
"4qaf",
"4run",
"5t43",
"7dru",
"8aeh",
"8epu",
"8epv",
"8vqf",
"8vqg",
"9npg",
"9nph",
"9npi"
] | 14 | [
"PUB00001268",
"PUB00006099",
"PUB00006109",
"PUB00006117",
"PUB00006123",
"PUB00006125",
"PUB00006135"
] | [
"7813422",
"1689010",
"1400345",
"8168376",
"7878087",
"7648862",
"9497502"
] | [
"Possible pheromone-carrier function of two lipocalin proteins in the vomeronasal organ.",
"Possible role for salivary gland protein in taste reception indicated by homology to lipophilic-ligand carrier proteins.",
"cDNA cloning and sequencing reveals human tear prealbumin to be a member of the lipophilic-ligan... | [
1994,
1990,
1992,
1993,
1994,
1995,
1997
] | 7 | [
"IPR002345"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
487
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
6,
23
] | 3 | true | Family | von Ebner's gland protein/ Bos/Can allergen | von Ebner's gland protein/ Bos/Can allergen | von_Ebner_gland | 7 |
IPR002453 | 2,453 | Beta tubulin | Beta_tubulin | Family | 53,831 | false | false | Microtubules are polymers of tubulin, a dimer of two 55kDa subunits, designated alpha and beta [ , ]. Within the microtubule lattice, α-β heterodimers associate in a head-to-tail fashion, giving rise to microtubule polarity. Fluorescent labelling studies have suggested that tubulin is oriented in microtubules with beta... | [
"GO:0003924",
"GO:0005200",
"GO:0005525",
"GO:0007017",
"GO:0005874"
] | [
"GTPase activity",
"structural constituent of cytoskeleton",
"GTP binding",
"microtubule-based process",
"microtubule"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 5 | [
"PRINTS"
] | [
"PR01163"
] | [
"BETATUBULIN"
] | [
53831
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-190840",
"R-BTA-2132295",
"R-BTA-2467813",
"R-BTA-2500257",
"R-BTA-2565942",
"R-BTA-3371497",
"R-BTA-380259",
"R-BTA-380270",
"R-BTA-380284",
"R-BTA-380320",
"R-BTA-5610787",
"R-BTA-5617833",
"R-BTA-5620912",
"R-BTA-5620924",
"R-BTA-5626467",
"R-BTA-5663220",
"R-BTA-6798695",
... | [
"REACTOME:R-BTA-190840",
"REACTOME:R-BTA-2132295",
"REACTOME:R-BTA-2467813",
"REACTOME:R-BTA-2500257",
"REACTOME:R-BTA-2565942",
"REACTOME:R-BTA-3371497",
"REACTOME:R-BTA-380259",
"REACTOME:R-BTA-380270",
"REACTOME:R-BTA-380284",
"REACTOME:R-BTA-380320",
"REACTOME:R-BTA-5610787",
"REACTOME:R-B... | 185 | [
"1ffx",
"1ia0",
"1jff",
"1sa0",
"1sa1",
"1tub",
"1tvk",
"1z2b",
"2btq",
"2hxf",
"2hxh",
"2p4n",
"2wbe",
"2xrp",
"3dco",
"3du7",
"3e22",
"3edl",
"3hkb",
"3hkc",
"3hkd",
"3hke",
"3iz0",
"3j1t",
"3j1u",
"3j2u",
"3j6e",
"3j6f",
"3j6g",
"3j6h",
"3j6p",
"3j7i"... | 736 | [
"PUB00000039",
"PUB00000721",
"PUB00000978",
"PUB00002443",
"PUB00006090",
"PUB00006112"
] | [
"3896122",
"8274140",
"2194680",
"3680207",
"3999141",
"8102497"
] | [
"Molecular biology and genetics of tubulin.",
"Gamma-tubulin: the hub of cellular microtubule assemblies.",
"Diversity among tubulin subunits: toward what functional end?",
"Tubulin sequence region beta 155-174 is involved in binding exchangeable guanosine triphosphate.",
"Three expressed sequences within t... | [
1985,
1993,
1990,
1987,
1985,
1993
] | 6 | [
"IPR000217"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Promethearchaeati"
] | [
17,
53811,
3
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
25,
6,
14,
13,
80,
20,
1,
18,
28,
1,
1,
103
] | 12 | true | Family | Beta tubulin | Beta tubulin | Beta_tubulin | 8 |
IPR002454 | 2,454 | Gamma tubulin | Gamma_tubulin | Family | 5,202 | false | false | Gamma-tubulins constitute a ubiquitous and highly-conserved subfamily of the tubulin family. Gamma is a low abundance protein present within the cells in both various types of microtubule-organizing centers and cytoplasmic protein complexes. The protein recruits the alpha/beta-tubulin dimers that form the minus ends of... | [
"GO:0007020",
"GO:0031122",
"GO:0000930"
] | [
"microtubule nucleation",
"cytoplasmic microtubule organization",
"gamma-tubulin complex"
] | [
"biological_process",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS",
"CDD"
] | [
"PR01164",
"cd02188"
] | [
"GAMMATUBULIN",
"gamma_tubulin"
] | [
5141,
4826
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
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"REACTOME",
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"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-2565942",
"R-BTA-380259",
"R-BTA-380270",
"R-BTA-380284",
"R-BTA-380320",
"R-BTA-5620912",
"R-BTA-8854518",
"R-HSA-2565942",
"R-HSA-380259",
"R-HSA-380270",
"R-HSA-380284",
"R-HSA-380320",
"R-HSA-5620912",
"R-HSA-8854518",
"R-MMU-2565942",
"R-MMU-380259",
"R-MMU-380270",
"R-... | [
"REACTOME:R-BTA-2565942",
"REACTOME:R-BTA-380259",
"REACTOME:R-BTA-380270",
"REACTOME:R-BTA-380284",
"REACTOME:R-BTA-380320",
"REACTOME:R-BTA-5620912",
"REACTOME:R-BTA-8854518",
"REACTOME:R-HSA-2565942",
"REACTOME:R-HSA-380259",
"REACTOME:R-HSA-380270",
"REACTOME:R-HSA-380284",
"REACTOME:R-HSA... | 28 | [
"1z5v",
"1z5w",
"3cb2",
"5flz",
"5fm1",
"6tf9",
"6v5v",
"6v6s",
"7anz",
"7as4",
"7m2w",
"7m2x",
"7m2y",
"7m2z",
"7qj0",
"7qj1",
"7qj2",
"7qj3",
"7qj4",
"7qj5",
"7qj6",
"7qj7",
"7qj8",
"7qj9",
"7qja",
"7qjb",
"7qjc",
"7qjd",
"7qje",
"8q62",
"8qv2",
"8qv3"... | 51 | [
"PUB00066498",
"PUB00072959",
"PUB00102118"
] | [
"17178454",
"25169981",
"25339375"
] | [
"Gamma-tubulin complexes and microtubule organization.",
"Six subgroups and extensive recent duplications characterize the evolution of the eukaryotic tubulin protein family.",
"Molecular evolution and functional divergence of tubulin superfamily in the fungal tree of life."
] | [
2007,
2014,
2014
] | 3 | [
"IPR000217"
] | [] | 1 | 0 | 1 | [
"Candidatus Lokiarchaeum ossiferum",
"Eukaryota"
] | [
1,
5201
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
2,
3,
6,
4,
1,
2,
5,
1,
1,
26
] | 12 | true | Family | Gamma tubulin | Gamma tubulin | Gamma_tubulin | 1 |
IPR002455 | 2,455 | GPCR family 3, GABA-B receptor | GPCR3_GABA-B | Family | 9,816 | false | false | GPCR family 3 receptors (also known as family C) are structurally similar to other GPCRs, but do not show any significant sequence similarity and thus represent a distinct group. Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region cont... | [
"GO:0004965",
"GO:0007186",
"GO:0016020"
] | [
"G protein-coupled GABA receptor activity",
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PANTHER"
] | [
"PTHR10519"
] | [
""
] | [
9816
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
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"REACTOME",
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"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-1296041",
"R-CEL-418594",
"R-CEL-420499",
"R-CEL-977444",
"R-CEL-997272",
"R-DDI-418594",
"R-DDI-420499",
"R-DDI-977444",
"R-HSA-1296041",
"R-HSA-418594",
"R-HSA-420499",
"R-HSA-977444",
"R-HSA-997272",
"R-MMU-1296041",
"R-MMU-418594",
"R-MMU-420499",
"R-MMU-977444",
"R-MMU-... | [
"REACTOME:R-CEL-1296041",
"REACTOME:R-CEL-418594",
"REACTOME:R-CEL-420499",
"REACTOME:R-CEL-977444",
"REACTOME:R-CEL-997272",
"REACTOME:R-DDI-418594",
"REACTOME:R-DDI-420499",
"REACTOME:R-DDI-977444",
"REACTOME:R-HSA-1296041",
"REACTOME:R-HSA-418594",
"REACTOME:R-HSA-420499",
"REACTOME:R-HSA-9... | 23 | [
"4f11",
"4f12",
"4mqe",
"4mqf",
"4mr7",
"4mr8",
"4mr9",
"4mrm",
"4ms1",
"4ms3",
"4ms4",
"6uo8",
"6uo9",
"6uoa",
"6vjm",
"6w2x",
"6w2y",
"6wiv",
"7c7q",
"7c7s",
"7ca3",
"7ca5",
"7cum",
"7eb2",
"8ieb",
"8ied",
"8iei",
"8iep",
"8ieq",
"8yjp",
"8yk0",
"9jqx"... | 33 | [
"PUB00004161",
"PUB00004309",
"PUB00005965",
"PUB00005966",
"PUB00005967",
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"PUB00036050",
"PUB00062692",
"PUB00070398",
"PUB00076358",
"PUB00095650",
"PUB00095651",
"PUB00155083"
] | [
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"9069281",
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"17266540",
"10773016",
"22660477",
"17501984",
"17950724",
"24305054",
"18165688",
"38332368"
] | [
"Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid.",
"A family of metabotropic glutamate receptors.",
"Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.",
"Human gamma-aminobutyric acid type B receptors are differen... | [
1993,
1992,
1997,
1998,
1998,
1997,
2007,
2000,
2012,
2007,
2007,
2013,
2008,
2024
] | 14 | [] | [
"IPR002456",
"IPR002457"
] | 0 | 2 | 0 | [
"Eukaryota",
"Solumvirus sp.",
"bird metagenome"
] | [
9814,
1,
1
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
14,
13,
20,
7,
15
] | 6 | true | Family | GPCR family 3, GABA-B receptor | GPCR family 3, GABA-B receptor | GPCR3_GABA-B | 6 |
IPR002456 | 2,456 | GPCR family 3, gamma-aminobutyric acid receptor, type B1 | GPCR_3_GABA_rcpt_B1 | Family | 1,937 | false | false | GPCR family 3 receptors (also known as family C) are structurally similar to other GPCRs, but do not show any significant sequence similarity and thus represent a distinct group. Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region cont... | [
"GO:0004965",
"GO:0007186",
"GO:0016020"
] | [
"G protein-coupled GABA receptor activity",
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"CDD"
] | [
"cd15291"
] | [
"7tmC_GABA-B-R1"
] | [
1937
] | 1 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"240",
"R-CEL-1296041",
"R-CEL-418594",
"R-CEL-420499",
"R-CEL-977444",
"R-CEL-997272",
"R-HSA-1296041",
"R-HSA-418594",
"R-HSA-420499",
"R-HSA-977444",
"R-HSA-997272",
"R-MMU-1296041",
"R-MMU-418594",
"R-MMU-420499",
"R-MMU-977444",
"R-MMU-997272",
"R-RNO-1296041",
"R-RNO-418594",... | [
"IUPHAR:240",
"REACTOME:R-CEL-1296041",
"REACTOME:R-CEL-418594",
"REACTOME:R-CEL-420499",
"REACTOME:R-CEL-977444",
"REACTOME:R-CEL-997272",
"REACTOME:R-HSA-1296041",
"REACTOME:R-HSA-418594",
"REACTOME:R-HSA-420499",
"REACTOME:R-HSA-977444",
"REACTOME:R-HSA-997272",
"REACTOME:R-MMU-1296041",
... | 21 | [
"6uo8",
"6uo9",
"6uoa",
"6vjm",
"6w2x",
"6w2y",
"6wiv",
"7c7q",
"7c7s",
"7ca3",
"7ca5",
"7cum",
"7eb2",
"9jqx",
"9jr0"
] | 15 | [
"PUB00004161",
"PUB00004309",
"PUB00005965",
"PUB00005966",
"PUB00005967",
"PUB00007343",
"PUB00018697",
"PUB00036049",
"PUB00036050",
"PUB00086572"
] | [
"8255296",
"1309649",
"9069281",
"9844003",
"9872316",
"9292726",
"9933300",
"17266540",
"10773016",
"16672332"
] | [
"Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid.",
"A family of metabotropic glutamate receptors.",
"Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.",
"Human gamma-aminobutyric acid type B receptors are differen... | [
1993,
1992,
1997,
1998,
1998,
1997,
1998,
2007,
2000,
2006
] | 10 | [
"IPR002455"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
1937
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
4,
3,
14,
2,
7
] | 6 | true | Family | GPCR family 3, gamma-aminobutyric acid receptor, type B1 | GPCR family 3, gamma-aminobutyric acid receptor, type B1 | GPCR_3_GABA_rcpt_B1 | 5 |
IPR002457 | 2,457 | GPCR family 3, gamma-aminobutyric acid receptor, type B2 | GPCR_3_GABA_rcpt_B2 | Family | 969 | false | false | GPCR family 3 receptors (also known as family C) are structurally similar to other GPCRs, but do not show any significant sequence similarity and thus represent a distinct group. Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region cont... | [
"GO:0004965",
"GO:0007186",
"GO:0016020"
] | [
"G protein-coupled GABA receptor activity",
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01178"
] | [
"GABAB2RECPTR"
] | [
969
] | 1 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"241",
"R-HSA-1296041",
"R-HSA-418594",
"R-HSA-420499",
"R-HSA-977444",
"R-HSA-997272",
"R-MMU-1296041",
"R-MMU-418594",
"R-MMU-420499",
"R-MMU-977444",
"R-MMU-997272",
"R-RNO-1296041",
"R-RNO-418594",
"R-RNO-420499",
"R-RNO-977444",
"R-RNO-997272"
] | [
"IUPHAR:241",
"REACTOME:R-HSA-1296041",
"REACTOME:R-HSA-418594",
"REACTOME:R-HSA-420499",
"REACTOME:R-HSA-977444",
"REACTOME:R-HSA-997272",
"REACTOME:R-MMU-1296041",
"REACTOME:R-MMU-418594",
"REACTOME:R-MMU-420499",
"REACTOME:R-MMU-977444",
"REACTOME:R-MMU-997272",
"REACTOME:R-RNO-1296041",
... | 16 | [
"4f11",
"4f12",
"4mqe",
"4mqf",
"4mr7",
"4mr8",
"4mr9",
"4mrm",
"4ms1",
"4ms3",
"4ms4",
"6uo8",
"6uo9",
"6uoa",
"6vjm",
"6w2x",
"6wiv",
"7c7q",
"7c7s",
"7ca3",
"7ca5",
"7cum",
"7eb2"
] | 23 | [
"PUB00004161",
"PUB00004309",
"PUB00005965",
"PUB00005966",
"PUB00005967",
"PUB00007343",
"PUB00036049",
"PUB00036050"
] | [
"8255296",
"1309649",
"9069281",
"9844003",
"9872316",
"9292726",
"17266540",
"10773016"
] | [
"Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid.",
"A family of metabotropic glutamate receptors.",
"Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.",
"Human gamma-aminobutyric acid type B receptors are differen... | [
1993,
1992,
1997,
1998,
1998,
1997,
2007,
2000
] | 8 | [
"IPR002455"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
969
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
2,
1,
4
] | 4 | true | Family | GPCR family 3, gamma-aminobutyric acid receptor, type B2 | GPCR family 3, gamma-aminobutyric acid receptor, type B2 | GPCR_3_GABA_rcpt_B2 | 6 |
IPR002460 | 2,460 | Alpha-synuclein | Synuclein_alpha | Family | 816 | false | false | Synucleins are small, soluble proteins expressed primarily in neural tissue and in certain tumours [ , ]. The family includes three known proteins: alpha-synuclein, beta-synuclein, and gamma-synuclein. All synucleins have in common a highly conserved α-helical lipid-binding motif with similarity to the class-A2 lipid-b... | [
"GO:0014059",
"GO:0005737"
] | [
"regulation of dopamine secretion",
"cytoplasm"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01212"
] | [
"ASYNUCLEIN"
] | [
816
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-9833482",
"R-HSA-977225",
"R-HSA-9833482",
"R-MMU-9833482",
"R-RNO-9833482",
"R-SSC-9833482"
] | [
"REACTOME:R-BTA-9833482",
"REACTOME:R-HSA-977225",
"REACTOME:R-HSA-9833482",
"REACTOME:R-MMU-9833482",
"REACTOME:R-RNO-9833482",
"REACTOME:R-SSC-9833482"
] | 6 | [
"1xq8",
"2kkw",
"2n0a",
"6a6b",
"6cu7",
"6cu8",
"6h6b",
"6l1t",
"6l1u",
"6l4s",
"6lrq",
"6osj",
"6osl",
"6osm",
"6peo",
"6pes",
"6rt0",
"6rtb",
"6sst",
"6ssx",
"6ufr",
"6xyo",
"6xyp",
"6xyq",
"7c1d",
"7e0f",
"7l7h",
"7lc9",
"7nca",
"7ncg",
"7nch",
"7nci"... | 169 | [
"PUB00001947",
"PUB00006124",
"PUB00007113",
"PUB00007114",
"PUB00007115",
"PUB00007116",
"PUB00007117",
"PUB00007118",
"PUB00095328",
"PUB00095329"
] | [
"9750188",
"7646890",
"11806835",
"10952980",
"7857654",
"7877458",
"9044857",
"11433374",
"30404828",
"20798282"
] | [
"The synuclein family.",
"Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.",
"The synucleins.",
"Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis.",
"The... | [
1998,
1995,
2002,
2000,
1995,
1994,
1997,
2001,
2018,
2010
] | 10 | [
"IPR001058"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
816
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
1,
3
] | 3 | true | Family | Alpha-synuclein | Alpha-synuclein | Synuclein_alpha | 3 |
IPR002461 | 2,461 | Beta-synuclein | Synuclein_beta | Family | 869 | false | false | Synucleins are small, soluble proteins expressed primarily in neural tissue and in certain tumors [ , ]. The family includes three known proteins: alpha-synuclein, beta-synuclein, and gamma-synuclein. All synucleins have in common a highly conserved α-helical lipid-binding motif with similarity to the class-A2 lipid-bi... | [
"GO:0005737"
] | [
"cytoplasm"
] | [
"cellular_component"
] | 1 | [
"PRINTS"
] | [
"PR01213"
] | [
"BSYNUCLEIN"
] | [
869
] | 1 | [
"REACTOME"
] | [
"R-HSA-5660489"
] | [
"REACTOME:R-HSA-5660489"
] | 1 | [] | 0 | [
"PUB00001947",
"PUB00006114",
"PUB00006535",
"PUB00007113",
"PUB00007114",
"PUB00007115",
"PUB00007116",
"PUB00007117",
"PUB00007118"
] | [
"9750188",
"8223629",
"10813729",
"11806835",
"10952980",
"7857654",
"7877458",
"9044857",
"11433374"
] | [
"The synuclein family.",
"A new brain-specific 14-kDa protein is a phosphoprotein. Its complete amino acid sequence and evidence for phosphorylation.",
"Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary.",
"The synucleins.",
"Interaction of h... | [
1998,
1993,
2000,
2002,
2000,
1995,
1994,
1997,
2001
] | 9 | [
"IPR001058"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
869
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
1,
5
] | 4 | true | Family | Beta-synuclein | Beta-synuclein | Synuclein_beta | 8 |
IPR002462 | 2,462 | Gamma-synuclein | Synuclein_gamma | Family | 960 | false | false | Synucleins are small, soluble proteins expressed primarily in neural tissue and in certain tumors [ , ]. The family includes three known proteins: alpha-synuclein, beta-synuclein, and gamma-synuclein. All synucleins have in common a highly conserved α-helical lipid-binding motif with similarity to the class-A2 lipid-bi... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR01214"
] | [
"GSYNUCLEIN"
] | [
960
] | 1 | [] | [] | [] | 0 | [
"7wnz",
"7wo0",
"8gf7",
"8zlp",
"8zmy",
"9jby",
"9jdk",
"9jke",
"9rzf"
] | 9 | [
"PUB00001947",
"PUB00006136",
"PUB00006500",
"PUB00006535",
"PUB00007113",
"PUB00007114",
"PUB00007115",
"PUB00007116",
"PUB00007117",
"PUB00007118"
] | [
"9750188",
"9700196",
"10195122",
"10813729",
"11806835",
"10952980",
"7857654",
"7877458",
"9044857",
"11433374"
] | [
"The synuclein family.",
"Organization, expression and polymorphism of the human persyn gene.",
"Persyn, a member of the synuclein family, influences neurofilament network integrity.",
"Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary.",
"Th... | [
1998,
1998,
1998,
2000,
2002,
2000,
1995,
1994,
1997,
2001
] | 10 | [
"IPR001058"
] | [] | 1 | 0 | 1 | [
"Vertebrata"
] | [
960
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
2,
7
] | 4 | true | Family | Gamma-synuclein | Gamma-synuclein | Synuclein_gamma | 3 |
IPR002463 | 2,463 | Ornatin | Ornatin | Family | 7 | false | false | Ornatin is a potent glycoprotein IIb-IIIa (GP IIb-IIIa) antagonist and platelet aggregation inhibitor [ ]. The protein is 41-52 residues in length and contains the RGD recognition motif common in adhesion proteins, and 6 conserved cysteine residues. The sequences of ornatin isoforms B, C, D and E are highly similar, wh... | [
"GO:0007155",
"GO:0030193",
"GO:0005576"
] | [
"cell adhesion",
"regulation of blood coagulation",
"extracellular region"
] | [
"biological_process",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PRINTS"
] | [
"PF02088",
"PR01184"
] | [
"Ornatin",
"ORNATIN"
] | [
7,
7
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00006106"
] | [
"1765068"
] | [
"Ornatins: potent glycoprotein IIb-IIIa antagonists and platelet aggregation inhibitors from the leech Placobdella ornata."
] | [
1991
] | 1 | [] | [] | 0 | 0 | null | [
"Placobdella ornata"
] | [
7
] | 1 | [] | [] | 0 | true | Family | Ornatin | Ornatin | Ornatin | 1 |
IPR002464 | 2,464 | DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site | DNA/RNA_helicase_DEAH_CS | Conserved_site | 76,605 | false | false | A number of eukaryotic and prokaryotic proteins have been characterised [ , , ] on the basis of their structural similarity. They all seem to be involved in ATP-dependent, nucleic-acid unwinding. There are two subfamilies of such proteins, the D-E-A-D-box and D-E-A-H-box families. Proteins that belong to the subfamily ... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS00690"
] | [
"DEAH_ATP_HELICASE"
] | [
76605
] | 1 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.6.4",
"PDOC00039",
"R-BTA-113418",
"R-BTA-159236",
"R-BTA-1810476",
"R-BTA-3134963",
"R-BTA-5696395",
"R-BTA-5696400",
"R-BTA-674695",
"R-BTA-6781823",
"R-BTA-6782135",
"R-BTA-6782210",
"R-BTA-6796648",
"R-BTA-72086",
"R-BTA-72163",
"R-BTA-72187",
"R-BTA-73762",
"R-BTA-73772",
... | [
"EC:3.6.4",
"PROSITEDOC:PDOC00039",
"REACTOME:R-BTA-113418",
"REACTOME:R-BTA-159236",
"REACTOME:R-BTA-1810476",
"REACTOME:R-BTA-3134963",
"REACTOME:R-BTA-5696395",
"REACTOME:R-BTA-5696400",
"REACTOME:R-BTA-674695",
"REACTOME:R-BTA-6781823",
"REACTOME:R-BTA-6782135",
"REACTOME:R-BTA-6782210",
... | 186 | [
"2xau",
"3kx2",
"3llm",
"4cdg",
"4cgz",
"4o3m",
"5aor",
"5d0u",
"5fmf",
"5gm6",
"5i8q",
"5ivw",
"5iy6",
"5iy7",
"5iy8",
"5iy9",
"5jpt",
"5lb3",
"5lb5",
"5lb8",
"5lba",
"5lj5",
"5lqw",
"5lta",
"5ltj",
"5ltk",
"5mq0",
"5mqf",
"5n8r",
"5n8s",
"5n8u",
"5n8z"... | 255 | [
"PUB00003151",
"PUB00003826",
"PUB00004021",
"PUB00004037",
"PUB00004089",
"PUB00004395"
] | [
"1321883",
"1552844",
"3362205",
"2563148",
"1825133",
"1956796"
] | [
"Vaccinia virus encodes four putative DNA and/or RNA helicases distantly related to each other.",
"D-E-A-D protein family of putative RNA helicases.",
"A new superfamily of replicative proteins.",
"Birth of the D-E-A-D box.",
"RNA splicing. Alive with DEAD proteins.",
"The RAD3 gene is a member of the DEA... | [
1992,
1992,
1988,
1989,
1991,
1991
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
283,
9688,
66082,
348,
204
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
75,
14,
60,
51,
128,
63,
12,
42,
85,
9,
10,
90
] | 12 | true | Conserved_site | DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site | DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site | DNA/RNA_helicase_DEAH_CS | 2 |
IPR002466 | 2,466 | Adenosine deaminase/editase | A_deamin | Domain | 12,537 | false | false | Editase ( ) are enzymes that alter mRNA by catalyzing the site-selective deamination of adenosine residue into inosine residue. The editase domain contains the active site and binds three Zn atoms [ ]. Several editases share a common global arrangement of domains, from N to C terminus: two 'double-stranded RNA-specific... | [
"GO:0003723",
"GO:0004000",
"GO:0006396"
] | [
"RNA binding",
"adenosine deaminase activity",
"RNA processing"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF02137",
"PS50141",
"SM00552"
] | [
"A_deamin",
"A_DEAMIN_EDITASE",
"ADEAMc"
] | [
12289,
12465,
11512
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC50141",
"R-CEL-75102",
"R-CEL-77042",
"R-DME-75102",
"R-DME-77042",
"R-HSA-6782315",
"R-HSA-75102",
"R-HSA-77042",
"R-HSA-909733",
"R-HSA-9833482",
"R-MMU-75102",
"R-MMU-77042",
"R-MMU-9833482",
"R-RNO-75102",
"R-RNO-77042",
"R-RNO-9833482"
] | [
"PROSITEDOC:PDOC50141",
"REACTOME:R-CEL-75102",
"REACTOME:R-CEL-77042",
"REACTOME:R-DME-75102",
"REACTOME:R-DME-77042",
"REACTOME:R-HSA-6782315",
"REACTOME:R-HSA-75102",
"REACTOME:R-HSA-77042",
"REACTOME:R-HSA-909733",
"REACTOME:R-HSA-9833482",
"REACTOME:R-MMU-75102",
"REACTOME:R-MMU-77042",
... | 16 | [
"1zy7",
"5ed1",
"5ed2",
"5hp2",
"5hp3",
"6d06",
"6vff",
"7kfn",
"8e0f",
"8e4x",
"8wfb",
"8zen",
"8zeo",
"8zep",
"9b83",
"9b84",
"9b89",
"9d5j",
"9d5k",
"9dp5",
"9op3"
] | 21 | [
"PUB00006132"
] | [
"9159072"
] | [
"Mammalian RNA-dependent deaminases and edited mRNAs."
] | [
1997
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Influenza A virus (A/Mexico City/INER13/2009(H1N1))",
"metagenomes"
] | [
45,
12488,
1,
3
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
7,
3,
24,
17,
37,
15,
1,
6,
33,
1,
1,
16
] | 12 | true | Domain | Adenosine deaminase/editase | Adenosine deaminase/editase | A_deamin | 5 |
IPR002467 | 2,467 | Peptidase M24A, methionine aminopeptidase, subfamily 1 | Pept_M24A_MAP1 | Family | 51,159 | false | false | This group of metallopeptidases belong to MEROPS peptidase family M24 (clan MG), subfamily M24A. Methionine aminopeptidase ( ) (MAP) catalyses the hydrolytic cleavage of the N-terminal methionine from newly synthesised polypeptides if the penultimate amino acid is small, with different tolerance to Val and Thr at this ... | [
"GO:0070006",
"GO:0006508"
] | [
"metalloaminopeptidase activity",
"proteolysis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"PROSITE",
"NCBIFAM",
"CDD"
] | [
"MF_01974",
"PS00680",
"TIGR00500",
"cd01086"
] | [
"MetAP_1",
"MAP_1",
"met_pdase_I",
"MetAP1"
] | [
49605,
33549,
50345,
48923
] | 4 | [
"EC",
"GP",
"METACYC",
"METACYC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.4.11.18",
"GenProp1491",
"PWY-7799",
"PWY-7800",
"PDOC00575",
"R-BTA-2514859",
"R-DDI-2514859",
"R-DRE-2514859",
"R-HSA-2514859",
"R-MMU-2514859",
"R-SCE-2514859",
"R-SPO-2514859",
"R-XTR-2514859"
] | [
"EC:3.4.11.18",
"GP:GenProp1491",
"METACYC:PWY-7799",
"METACYC:PWY-7800",
"PROSITEDOC:PDOC00575",
"REACTOME:R-BTA-2514859",
"REACTOME:R-DDI-2514859",
"REACTOME:R-DRE-2514859",
"REACTOME:R-HSA-2514859",
"REACTOME:R-MMU-2514859",
"REACTOME:R-SCE-2514859",
"REACTOME:R-SPO-2514859",
"REACTOME:R-... | 13 | [
"1c21",
"1c22",
"1c23",
"1c24",
"1c27",
"1mat",
"1o0x",
"1qxw",
"1qxy",
"1qxz",
"1xnz",
"1y1n",
"1yj3",
"1yvm",
"2b3h",
"2b3k",
"2b3l",
"2bb7",
"2evc",
"2evm",
"2evo",
"2g6p",
"2gg0",
"2gg2",
"2gg3",
"2gg5",
"2gg7",
"2gg8",
"2gg9",
"2ggb",
"2ggc",
"2gtx"... | 129 | [
"PUB00000379",
"PUB00004871",
"PUB00005454",
"PUB00070140"
] | [
"8471602",
"7644482",
"8772380",
"20521764"
] | [
"Structure of the cobalt-dependent methionine aminopeptidase from Escherichia coli: a new type of proteolytic enzyme.",
"Eukaryotic methionyl aminopeptidases: two classes of cobalt-dependent enzymes.",
"Methionine aminopeptidase-1: the MAP of the mitochondrion?",
"Protein N-terminal processing: substrate spec... | [
1993,
1995,
1996,
2010
] | 4 | [
"IPR001714"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"unclassified sequences",
"uncultured Caudovirales phage"
] | [
41546,
8964,
2,
646,
1
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
21,
1,
7,
3,
1,
4,
5,
1,
15,
8,
1,
1,
52
] | 13 | true | Family | Peptidase M24A, methionine aminopeptidase, subfamily 1 | Peptidase M24A, methionine aminopeptidase, subfamily 1 | Pept_M24A_MAP1 | 5 |
IPR002469 | 2,469 | Dipeptidylpeptidase IV, N-terminal domain | Peptidase_S9B_N | Domain | 34,565 | false | false | This domain defines serine peptidases belonging to MEROPS peptidase family S9 (clan SC), subfamily S9B (dipeptidyl-peptidase IV). The protein fold of the peptidase domain for members of this family resembles that of serine carboxypeptidase D, the type example of clan SC. This domain is an alignment of the region to the... | [
"GO:0006508"
] | [
"proteolysis"
] | [
"biological_process"
] | 1 | [
"PFAM"
] | [
"PF00930"
] | [
"DPPIV_N"
] | [
34565
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.4.14.5",
"R-BTA-381771",
"R-BTA-400511",
"R-CEL-381771",
"R-HSA-381771",
"R-HSA-400511",
"R-MMU-381771",
"R-MMU-400511",
"R-RNO-381771",
"R-RNO-400511",
"R-SCE-381771",
"R-SPO-381771",
"R-SSC-381771",
"R-SSC-400511"
] | [
"EC:3.4.14.5",
"REACTOME:R-BTA-381771",
"REACTOME:R-BTA-400511",
"REACTOME:R-CEL-381771",
"REACTOME:R-HSA-381771",
"REACTOME:R-HSA-400511",
"REACTOME:R-MMU-381771",
"REACTOME:R-MMU-400511",
"REACTOME:R-RNO-381771",
"REACTOME:R-RNO-400511",
"REACTOME:R-SCE-381771",
"REACTOME:R-SPO-381771",
"R... | 14 | [
"1j2e",
"1n1m",
"1nu6",
"1nu8",
"1orv",
"1orw",
"1pfq",
"1r9m",
"1r9n",
"1rwq",
"1tk3",
"1tkr",
"1u8e",
"1w1i",
"1wcy",
"1x70",
"1xfd",
"1z68",
"2aj8",
"2ajb",
"2ajc",
"2ajd",
"2ajl",
"2bgn",
"2bgr",
"2bua",
"2bub",
"2buc",
"2d5l",
"2dcm",
"2ecf",
"2eep"... | 197 | [
"PUB00075598",
"PUB00075599",
"PUB00075601"
] | [
"1352530",
"20959412",
"21856036"
] | [
"Cloning and functional expression of the T cell activation antigen CD26.",
"Adenosine deaminase potentiates the generation of effector, memory, and regulatory CD4+ T cells.",
"Molecular mechanism and structural basis of interactions of dipeptidyl peptidase IV with adenosine deaminase and human immunodeficiency... | [
1992,
2011,
2012
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Mimivirus LCMiAC01",
"metagenomes"
] | [
52,
15564,
18617,
1,
331
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
9,
5,
35,
20,
41,
18,
1,
5,
36,
2,
2,
3
] | 12 | true | Domain | Dipeptidylpeptidase IV, N-terminal domain | Dipeptidylpeptidase IV, N-terminal domain | Peptidase_S9B_N | 4 |
IPR002470 | 2,470 | Peptidase S9A, prolyl oligopeptidase | Peptidase_S9A | Family | 35,728 | false | false | This group of serine peptidases belong to MEROPS peptidase family S9 (clan SC), subfamily S9A (prolyl oligopeptidase) which includes PREP and PREPL from human [ ], fungal prolyl oligopeptidases such as ophP, ledP, dbiP which are part of the gene cluster that mediates the biosynthesis of omphalotin A, lentinulin A, and ... | [
"GO:0004252",
"GO:0006508"
] | [
"serine-type endopeptidase activity",
"proteolysis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PRINTS"
] | [
"PR00862"
] | [
"PROLIGOPTASE"
] | [
35728
] | 1 | [
"EC",
"GP"
] | [
"3.4.21",
"GenProp2085"
] | [
"EC:3.4.21",
"GP:GenProp2085"
] | 2 | [
"1e5t",
"1e8m",
"1e8n",
"1h2w",
"1h2x",
"1h2y",
"1h2z",
"1o6f",
"1o6g",
"1qfm",
"1qfs",
"1uoo",
"1uop",
"1uoq",
"1vz2",
"1vz3",
"1yr2",
"2bkl",
"2xdw",
"2xe4",
"3ddu",
"3eq7",
"3eq8",
"3eq9",
"3iuj",
"3iul",
"3ium",
"3iun",
"3iuq",
"3iur",
"3ivm",
"3mun"... | 83 | [
"PUB00000522",
"PUB00003576",
"PUB00105757",
"PUB00151503",
"PUB00151504"
] | [
"8439290",
"7845208",
"28715095",
"28726805",
"33574430"
] | [
"Evolutionary families of peptidases.",
"Families of serine peptidases.",
"A Self-Sacrificing N-Methyltransferase Is the Precursor of the Fungal Natural Product Omphalotin.",
"PREPL deficiency: delineation of the phenotype and development of a functional blood assay.",
"Identification, heterologous producti... | [
1993,
1994,
2017,
2018,
2021
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified Klosneuvirinae",
"unclassified sequences"
] | [
539,
25752,
9106,
2,
329
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
31,
6,
6,
1,
5,
7,
16,
12,
46
] | 9 | true | Family | Peptidase S9A, prolyl oligopeptidase | Peptidase S9A, prolyl oligopeptidase | Peptidase_S9A | 5 |
IPR002471 | 2,471 | Peptidase S9, serine active site | Pept_S9_AS | Active_site | 24,581 | false | false | Proteolytic enzymes that exploit serine in their catalytic activity are ubiquitous, being found in viruses, bacteria and eukaryotes [ ]. They include a wide range of peptidase activity, including exopeptidase, endopeptidase, oligopeptidase and omega-peptidase activity. Many families of serine protease have been identif... | [
"GO:0004252",
"GO:0006508"
] | [
"serine-type endopeptidase activity",
"proteolysis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PROSITE"
] | [
"PS00708"
] | [
"PRO_ENDOPEP_SER"
] | [
24581
] | 1 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC00587",
"R-BTA-381771",
"R-BTA-400511",
"R-BTA-6798695",
"R-BTA-72764",
"R-HSA-381771",
"R-HSA-400511",
"R-HSA-6798695",
"R-HSA-72764",
"R-MMU-381771",
"R-MMU-400511",
"R-MMU-6798695",
"R-MMU-72764",
"R-RNO-381771",
"R-RNO-400511",
"R-RNO-6798695",
"R-RNO-72764",
"R-SCE-381771... | [
"PROSITEDOC:PDOC00587",
"REACTOME:R-BTA-381771",
"REACTOME:R-BTA-400511",
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-72764",
"REACTOME:R-HSA-381771",
"REACTOME:R-HSA-400511",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-72764",
"REACTOME:R-MMU-381771",
"REACTOME:R-MMU-400511",
"REACTOME:R-MMU-6798... | 20 | [
"1e5t",
"1h2w",
"1h2x",
"1h2y",
"1j2e",
"1n1m",
"1nu6",
"1nu8",
"1o6f",
"1o6g",
"1orv",
"1orw",
"1pfq",
"1qfm",
"1qfs",
"1r9m",
"1r9n",
"1rwq",
"1tk3",
"1tkr",
"1u8e",
"1vz2",
"1vz3",
"1w1i",
"1wcy",
"1x70",
"1yr2",
"1z68",
"2aj8",
"2ajb",
"2ajc",
"2ajd"... | 196 | [
"PUB00000522",
"PUB00003576"
] | [
"8439290",
"7845208"
] | [
"Evolutionary families of peptidases.",
"Families of serine peptidases."
] | [
1993,
1994
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified Klosneuvirinae",
"unclassified sequences"
] | [
152,
14738,
9534,
2,
155
] | 5 | [
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S28... | [
10,
6,
1,
20,
12,
1,
10,
23,
1,
1,
23
] | 11 | true | Active_site | Peptidase S9, serine active site | Peptidase S9, serine active site | Pept_S9_AS | 7 |
IPR002472 | 2,472 | Palmitoyl protein thioesterase | Palm_thioest | Family | 4,637 | false | false | This entry represents the palmitoyl protein thioesterase family. Its members include palmitoyl-protein thioesterase 1 and lysosomal thioesterase 2 (PPT1 and PPT2). PPT1 is responsible for the removal of a palmitate group from its substrate proteins, which may include presynaptic proteins like SNAP-25, cysteine string p... | [
"GO:0098599"
] | [
"palmitoyl hydrolase activity"
] | [
"molecular_function"
] | 1 | [
"PRINTS"
] | [
"PR00414"
] | [
"PPTHIESTRASE"
] | [
4637
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.1.2.2",
"3.1.2.22",
"PWY-1121",
"PWY-321",
"PWY-5972",
"PWY-5996",
"PWY-6733",
"PWY-7723",
"R-BTA-75105",
"R-CEL-75105",
"R-DME-75105",
"R-HSA-75105",
"R-MMU-75105",
"R-RNO-75105"
] | [
"EC:3.1.2.2",
"EC:3.1.2.22",
"METACYC:PWY-1121",
"METACYC:PWY-321",
"METACYC:PWY-5972",
"METACYC:PWY-5996",
"METACYC:PWY-6733",
"METACYC:PWY-7723",
"REACTOME:R-BTA-75105",
"REACTOME:R-CEL-75105",
"REACTOME:R-DME-75105",
"REACTOME:R-HSA-75105",
"REACTOME:R-MMU-75105",
"REACTOME:R-RNO-75105"... | 14 | [
"1eh5",
"1ei9",
"1exw",
"1pja",
"3gro"
] | 5 | [
"PUB00029881",
"PUB00072199",
"PUB00072200"
] | [
"12855696",
"24091420",
"23747979"
] | [
"The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2.",
"Mutations in palmitoyl-protein thioesterase 1 alter exocytosis and endocytosis at synapses in Drosophila larvae.",
"Pathogenesis and the... | [
2003,
2013,
2013
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
4636,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus"
] | [
16,
1,
4,
3,
18,
11,
1,
1,
8
] | 9 | true | Family | Palmitoyl protein thioesterase | Palmitoyl protein thioesterase | Palm_thioest | 6 |
IPR002474 | 2,474 | Carbamoyl-phosphate synthase small subunit, N-terminal domain | CarbamoylP_synth_ssu_N | Domain | 39,679 | false | false | This entry represents the N-terminal domain of the small subunit of carbamoyl phosphate synthase. Structurally, it forms a 3-layer β/β/α fold of a type that is thought to be mobile in most proteins that carry it [ , ]. | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF00988",
"SM01097"
] | [
"CPSase_sm_chain",
"CPSase_sm_chain"
] | [
39673,
39551
] | 2 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"6.3.5.5",
"PWY-5154",
"PWY-5686",
"PWY-7400",
"PWY-7790",
"PWY-7791",
"R-CEL-500753",
"R-DDI-500753",
"R-DME-500753",
"R-HSA-500753",
"R-HSA-70635",
"R-MMU-500753",
"R-MMU-70635",
"R-RNO-70635",
"R-SCE-500753",
"R-SPO-500753"
] | [
"EC:6.3.5.5",
"METACYC:PWY-5154",
"METACYC:PWY-5686",
"METACYC:PWY-7400",
"METACYC:PWY-7790",
"METACYC:PWY-7791",
"REACTOME:R-CEL-500753",
"REACTOME:R-DDI-500753",
"REACTOME:R-DME-500753",
"REACTOME:R-HSA-500753",
"REACTOME:R-HSA-70635",
"REACTOME:R-MMU-500753",
"REACTOME:R-MMU-70635",
"RE... | 16 | [
"1a9x",
"1bxr",
"1c30",
"1c3o",
"1ce8",
"1cs0",
"1jdb",
"1kee",
"1m6v",
"1t36",
"5dot",
"5dou",
"6uel",
"6w2j"
] | 14 | [
"PUB00023837",
"PUB00037058"
] | [
"10587438",
"11729189"
] | [
"The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathway.",
"Inactivation of the amidotransferase activity of carbamoyl phosphate synthetase by the antibiotic acivicin."
] | [
1999,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
818,
25377,
12861,
2,
621
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
8,
1,
7,
2,
1,
14,
6,
2,
4,
10,
2,
2,
11
] | 13 | true | Domain | Carbamoyl-phosphate synthase small subunit, N-terminal domain | Carbamoyl-phosphate synthase small subunit, N-terminal domain | CarbamoylP_synth_ssu_N | 2 |
IPR002475 | 2,475 | Bcl2-like | Bcl2-like | Family | 11,739 | false | false | B cell CLL/lymphoma-2 (Bcl-2) and related proteins comprise the Bcl-2 family. Bcl-2 proteins are central regulators of caspase activation, and play a key role in cell death by regulating the integrity of the mitochondrial and endoplasmic reticulum (ER) membranes [ ]. Though originally characterised with respect to thei... | [] | [] | [] | 0 | [
"PROFILE"
] | [
"PS50062"
] | [
"BCL2_FAMILY"
] | [
11739
] | 1 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00829",
"R-BTA-111457",
"R-BTA-114294",
"R-BTA-5620971",
"R-BTA-6804114",
"R-CEL-111453",
"R-CEL-9648002",
"R-GGA-111453",
"R-GGA-844455",
"R-GGA-9648002",
"R-HSA-111447",
"R-HSA-111452",
"R-HSA-111453",
"R-HSA-111457",
"R-HSA-114294",
"R-HSA-5620971",
"R-HSA-6785807",
"R-HSA-... | [
"PROSITEDOC:PDOC00829",
"REACTOME:R-BTA-111457",
"REACTOME:R-BTA-114294",
"REACTOME:R-BTA-5620971",
"REACTOME:R-BTA-6804114",
"REACTOME:R-CEL-111453",
"REACTOME:R-CEL-9648002",
"REACTOME:R-GGA-111453",
"REACTOME:R-GGA-844455",
"REACTOME:R-GGA-9648002",
"REACTOME:R-HSA-111447",
"REACTOME:R-HSA-... | 48 | [
"1af3",
"1bxl",
"1f16",
"1g5j",
"1g5m",
"1gjh",
"1k3k",
"1lxl",
"1maz",
"1mk3",
"1o0l",
"1ohu",
"1pq0",
"1pq1",
"1q59",
"1r2d",
"1r2e",
"1r2g",
"1r2h",
"1r2i",
"1ty4",
"1wsx",
"1ysg",
"1ysi",
"1ysn",
"1ysw",
"1zy3",
"2a5y",
"2b48",
"2bzw",
"2ims",
"2imt"... | 459 | [
"PUB00017301",
"PUB00049899",
"PUB00060365"
] | [
"12631689",
"18551131",
"20159550"
] | [
"Cellular distribution of Bcl-2 family proteins.",
"Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands.",
"The BCL-2 family reunion."
] | [
2003,
2008,
2010
] | 3 | [] | [
"IPR026298",
"IPR042398"
] | 0 | 2 | 0 | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
50,
11220,
464,
5
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
26,
5,
64,
45,
52
] | 6 | true | Family | Bcl2-like | Bcl2-like | Bcl2-like | 7 |
IPR002477 | 2,477 | Peptidoglycan binding-like | Peptidoglycan-bd-like | Domain | 93,144 | false | false | This entry represents peptidoglycan binding domain (PGBD), as well as related domains that share the same structure. PGBD may have a general peptidoglycan binding function. It has a core structure consisting of a closed, three-helical bundle with a left-handed twist. It is found at the N or C terminus of a variety of e... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01471"
] | [
"PG_binding_1"
] | [
93144
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.4.24",
"R-BTA-1433557",
"R-BTA-1442490",
"R-BTA-1474228",
"R-BTA-1592389",
"R-BTA-3928665",
"R-BTA-6798695",
"R-BTA-9009391",
"R-CEL-1442490",
"R-CEL-1474228",
"R-CEL-1592389",
"R-CEL-210991",
"R-CEL-2168880",
"R-CEL-2179392",
"R-CEL-3928665",
"R-CEL-6798695",
"R-CFA-1442490",
"... | [
"EC:3.4.24",
"REACTOME:R-BTA-1433557",
"REACTOME:R-BTA-1442490",
"REACTOME:R-BTA-1474228",
"REACTOME:R-BTA-1592389",
"REACTOME:R-BTA-3928665",
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-9009391",
"REACTOME:R-CEL-1442490",
"REACTOME:R-CEL-1474228",
"REACTOME:R-CEL-1592389",
"REACTOME:R-CEL-21099... | 61 | [
"1ck7",
"1eak",
"1gxd",
"1lbu",
"1slm",
"1su3",
"2mze",
"2mzh",
"2mzi",
"3bkh",
"3bkv",
"4bj4",
"4bol",
"4bpa",
"4c2c",
"4c2d",
"4c2e",
"4c2f",
"4c2g",
"4c2h",
"4fet",
"4g54",
"4lpq",
"4nso",
"4xxt",
"5anz",
"5ao7",
"5ao8",
"5nm7",
"5tv7",
"5ue2",
"5ue5"... | 46 | [
"PUB00003115",
"PUB00003979",
"PUB00006403",
"PUB00013218",
"PUB00013219",
"PUB00013220",
"PUB00013221",
"PUB00013222",
"PUB00013223"
] | [
"1683402",
"7121588",
"9555893",
"6743245",
"10190290",
"12810425",
"12888258",
"12950257",
"11956636"
] | [
"Cloning, expression, sequence analysis and biochemical characterization of an autolytic amidase of Bacillus subtilis 168 trpC2.",
"Structure of a Zn2+-containing D-alanyl-D-alanine-cleaving carboxypeptidase at 2.5 A resolution.",
"Lysis genes of the Bacillus subtilis defective prophage PBSX.",
"Active-site-d... | [
1991,
1982,
1998,
1984,
1999,
2003,
2003,
2003,
2002
] | 9 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
138,
69133,
22168,
873,
832
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
27,
1,
38,
9,
2,
53,
53,
11,
50,
11
] | 10 | true | Domain | Peptidoglycan binding-like | Peptidoglycan binding-like | Peptidoglycan-bd-like | 7 |
IPR002478 | 2,478 | PUA domain | PUA | Domain | 46,839 | false | false | The PUA (PseudoUridine synthase and Archaeosine transglycosylase) domain was named after the proteins in which it was first found [ ]. PUA is a highly conserved RNA-binding motif found in a wide range of archaeal, bacterial and eukaryotic proteins, including enzymes that catalyse tRNA and rRNA post-transcriptional modi... | [
"GO:0003723"
] | [
"RNA binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"SMART"
] | [
"PF01472",
"SM00359"
] | [
"PUA",
"PUA"
] | [
34057,
44482
] | 2 | [
"EC",
"GP",
"METACYC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.2.11",
"GenProp1735",
"PWY-6922",
"PDOC50890",
"R-CEL-171319",
"R-DDI-171319",
"R-DME-171319",
"R-GGA-417076",
"R-HSA-171319",
"R-HSA-6790901",
"R-HSA-6791226",
"R-MMU-171319",
"R-MMU-6791226",
"R-RNO-171319",
"R-RNO-6791226",
"R-SCE-171319",
"R-SPO-171319",
"R-SSC-6791226"
] | [
"EC:2.7.2.11",
"GP:GenProp1735",
"METACYC:PWY-6922",
"PROSITEDOC:PDOC50890",
"REACTOME:R-CEL-171319",
"REACTOME:R-DDI-171319",
"REACTOME:R-DME-171319",
"REACTOME:R-GGA-417076",
"REACTOME:R-HSA-171319",
"REACTOME:R-HSA-6790901",
"REACTOME:R-HSA-6791226",
"REACTOME:R-MMU-171319",
"REACTOME:R-M... | 18 | [
"1iq8",
"1it7",
"1it8",
"1j2b",
"1q7h",
"1r3e",
"1sqw",
"1t5y",
"1ze1",
"1ze2",
"1zs7",
"2ab4",
"2apo",
"2as0",
"2aus",
"2cx0",
"2cx1",
"2ey4",
"2hvy",
"2j5t",
"2j5v",
"2q07",
"2rfk",
"3c0k",
"3d79",
"3hax",
"3hay",
"3hjw",
"3hjy",
"3lwo",
"3lwp",
"3lwq"... | 86 | [
"PUB00003444",
"PUB00036063",
"PUB00036064",
"PUB00036065",
"PUB00036066",
"PUB00097515"
] | [
"10093218",
"17803682",
"16793063",
"16407303",
"16943774",
"24393395"
] | [
"Novel predicted RNA-binding domains associated with the translation machinery.",
"The PUA domain - a structural and functional overview.",
"The structure of the RNA m5C methyltransferase YebU from Escherichia coli reveals a C-terminal RNA-recruiting PUA domain.",
"The RNA-binding PUA domain of archaeal tRNA-... | [
1999,
2007,
2006,
2006,
2006,
2014
] | 6 | [] | [
"IPR004521",
"IPR005155"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Hyperionvirus sp.",
"unclassified sequences"
] | [
3781,
24619,
17873,
1,
565
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
23,
3,
7,
9,
2,
14,
13,
4,
10,
21,
5,
4,
28
] | 13 | true | Domain | PUA domain | PUA domain | PUA | 1 |
IPR002480 | 2,480 | DAHP synthetase, class II | DAHP_synth_2 | Family | 15,892 | false | false | Members of the 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthetase family ( ) catalyse the first step in aromatic amino acid biosynthesis from chorismate. Class I (see ) includes bacterial and yeast enzymes; class II includes higher plants and various microorganisms [ ]. They have minimal sequence identity an... | [
"GO:0003849",
"GO:0009073"
] | [
"3-deoxy-7-phosphoheptulonate synthase activity",
"aromatic amino acid family biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PANTHER",
"NCBIFAM"
] | [
"PF01474",
"PTHR21337",
"TIGR01358"
] | [
"DAHP_synth_2",
"",
"DAHP_synth_II"
] | [
15889,
15819,
11218
] | 3 | [
"EC",
"GP",
"METACYC",
"REACTOME"
] | [
"2.5.1.54",
"GenProp0001",
"PWY-6164",
"R-MTU-964903"
] | [
"EC:2.5.1.54",
"GP:GenProp0001",
"METACYC:PWY-6164",
"REACTOME:R-MTU-964903"
] | 4 | [
"2b7o",
"2w19",
"2w1a",
"2ypo",
"2ypp",
"2ypq",
"3kgf",
"3nud",
"3nue",
"3nv8",
"3pfp",
"3rzi",
"5ckv",
"5ckx",
"5e2l",
"5e40",
"5e4n",
"5e5g",
"5e7z",
"5ex4",
"5huc",
"5hud",
"5hue",
"5uxm",
"5uxn",
"5uxo",
"6bmc",
"6pbj"
] | 28 | [
"PUB00006352",
"PUB00039551"
] | [
"8760910",
"16288916"
] | [
"Evidence for a novel class of microbial 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase in Streptomyces coelicolor A3(2), Streptomyces rimosus and Neurospora crassa.",
"The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold a... | [
1996,
2005
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
10950,
4581,
361
] | 3 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
14,
1,
19,
71
] | 4 | true | Family | DAHP synthetase, class II | DAHP synthetase, class II | DAHP_synth_2 | 4 |
IPR002481 | 2,481 | Ferric-uptake regulator | FUR | Family | 58,916 | false | false | The Ferric uptake regulator (Fur) family includes metal ion uptake regulator proteins, which are responsible for controlling the intracellular concentration of iron in many bacteria. The Fur protein (a dimer having one Fe 2+ coordinated per monomer) acts as an iron-responsive, DNA-binding repressor protein that binds t... | [
"GO:0003700",
"GO:0006355"
] | [
"DNA-binding transcription factor activity",
"regulation of DNA-templated transcription"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PANTHER",
"CDD"
] | [
"PF01475",
"PTHR33202",
"cd07153"
] | [
"FUR",
"",
"Fur_like"
] | [
58332,
57623,
49052
] | 3 | [] | [] | [] | 0 | [
"1mzb",
"2fe3",
"2fu4",
"2o03",
"2rgv",
"2w57",
"2xig",
"3eyy",
"3f8n",
"3mwm",
"4ets",
"4i7h",
"4lmy",
"4mtd",
"4mte",
"4ray",
"4raz",
"4rb0",
"4rb1",
"4rb2",
"4rb3",
"5fd5",
"5fd6",
"5l0p",
"5nbc",
"5nhk",
"5nl9",
"6d57",
"6dk4",
"6h1c",
"7dh7",
"7dh8"... | 42 | [
"PUB00003390",
"PUB00010421",
"PUB00028991",
"PUB00040631",
"PUB00043368",
"PUB00048415",
"PUB00068181",
"PUB00079754",
"PUB00079755",
"PUB00079756",
"PUB00079757",
"PUB00079758",
"PUB00079759",
"PUB00079760",
"PUB00079761",
"PUB00079762",
"PUB00079763",
"PUB00079764",
"PUB000797... | [
"9784364",
"11931550",
"12581348",
"16925555",
"18452427",
"17213192",
"8522528",
"16774589",
"17216355",
"18945213",
"11466300",
"9765558",
"7590316",
"18259067",
"16553888",
"16489762",
"8196544",
"7798143",
"7765895",
"9503612",
"7812114",
"10387106",
"12177338",
"96... | [
"Binding of the fur (ferric uptake regulator) repressor of Escherichia coli to arrays of the GATAAT sequence.",
"Members of the Fur protein family regulate iron and zinc transport in E. coli and characteristics of the Fur-regulated fhuF protein.",
"Architecture of a protein central to iron homeostasis: crystal ... | [
1998,
2002,
2003,
2006,
2008,
2007,
1995,
2006,
2007,
2009,
2001,
1998,
1995,
2008,
2006,
2006,
1994,
1995,
1995,
1998,
1994,
1999,
2002,
1998,
1998,
2005,
2005,
1999,
1987
] | 29 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
199,
57678,
63,
4,
972
] | 5 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Ferric-uptake regulator | Ferric-uptake regulator | FUR | 6 |
IPR002483 | 2,483 | PWI domain | PWI_dom | Domain | 18,312 | false | false | The PWI domain, named after a highly conserved PWI tri-peptide located within its N-terminal region, is a ~80 amino acid module, which is found either at the N terminus or at the C terminus of eukaryotic proteins involved in pre-mRNA processing [ ]. It is generally found in association with other domains such as RRM an... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF01480",
"PS51025",
"SM00311"
] | [
"PWI",
"PWI",
"PWI"
] | [
18030,
11837,
11366
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-9930044",
"R-HSA-159236",
"R-HSA-72163",
"R-HSA-72187",
"R-HSA-73856",
"R-HSA-9013418",
"R-HSA-9013422",
"R-HSA-9930044",
"R-MMU-159236",
"R-MMU-72163",
"R-MMU-72187",
"R-MMU-73856",
"R-MMU-9013418",
"R-MMU-9013422",
"R-MMU-9930044"
] | [
"REACTOME:R-DME-9930044",
"REACTOME:R-HSA-159236",
"REACTOME:R-HSA-72163",
"REACTOME:R-HSA-72187",
"REACTOME:R-HSA-73856",
"REACTOME:R-HSA-9013418",
"REACTOME:R-HSA-9013422",
"REACTOME:R-HSA-9930044",
"REACTOME:R-MMU-159236",
"REACTOME:R-MMU-72163",
"REACTOME:R-MMU-72187",
"REACTOME:R-MMU-7385... | 15 | [
"1mp1",
"1x4q",
"3jcr",
"3v53",
"5o9z",
"5zwn",
"6ah0",
"6ahd",
"6ff4",
"6ff7",
"6g90",
"6n7x",
"6qw6",
"6qx9",
"7abg",
"7abh",
"7abi",
"7dvq",
"7oqc",
"7oqe",
"8h6e",
"8h6j",
"8h6k",
"8h6l",
"8i0p",
"8i0r",
"8q7n",
"8qo9",
"8qoz",
"8qp8",
"8qp9",
"8qpa"... | 42 | [
"PUB00005490",
"PUB00019777",
"PUB00153346",
"PUB00153347"
] | [
"10322432",
"12600940",
"25989903",
"31950173"
] | [
"The PWI motif: a new protein domain in splicing factors.",
"Structure and function of the PWI motif: a novel nucleic acid-binding domain that facilitates pre-mRNA processing.",
"The fission yeast MTREC complex targets CUTs and unspliced pre-mRNAs to the nuclear exosome.",
"The human ZC3H3 and RBM26/27 protei... | [
1999,
2003,
2015,
2020
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine sediment metagenome"
] | [
10,
18301,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
27,
8,
19,
5,
24,
17,
4,
13,
26,
1,
3,
86
] | 12 | true | Domain | PWI domain | PWI domain | PWI_dom | 8 |
IPR002484 | 2,484 | Arterivirus nucleocapsid | Arte_nucleocap | Family | 1,902 | false | false | Arterivirus are ssRNA positive-strand viruses with no DNA stage in their replication cycle. This family contains the viral nucleocapsid protein, which encapsidates the viral ssRNA. Porcine reproductive and respiratory syndrome virus (PRRSV) is the causative agent of both severe and persistent respiratory disease and re... | [
"GO:0019013"
] | [
"viral nucleocapsid"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF01481"
] | [
"Arteri_nucleo"
] | [
1902
] | 1 | [] | [] | [] | 0 | [
"1p65",
"2i9f"
] | 2 | [
"PUB00028004"
] | [
"14604534"
] | [
"Structure of the nucleocapsid protein of porcine reproductive and respiratory syndrome virus."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Nidovirales"
] | [
1902
] | 1 | [] | [] | 0 | true | Family | Arterivirus nucleocapsid | Arterivirus nucleocapsid | Arte_nucleocap | 6 |
IPR002486 | 2,486 | Nematode cuticle collagen, N-terminal | Col_cuticle_N | Domain | 10,949 | false | false | The function of this domain is unknown. It is found in the N-terminal region of nematode cuticle collagens (see ). Cuticle is a tough elastic structure secreted by hypodermal cells and is primarily composed of collagen proteins [ , ]. | [
"GO:0042302"
] | [
"structural constituent of cuticle"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"SMART"
] | [
"PF01484",
"SM01088"
] | [
"Col_cuticle_N",
"Col_cuticle_N"
] | [
10823,
10425
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00001774",
"PUB00001853"
] | [
"2753356",
"7828882"
] | [
"Sequence comparisons of developmentally regulated collagen genes of Caenorhabditis elegans.",
"Identification and analysis of a cuticular collagen-encoding gene from the plant-parasitic nematode Meloidogyne incognita."
] | [
1989,
1994
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
4,
10945
] | 2 | [
"Caenorhabditis elegans"
] | [
167
] | 1 | true | Domain | Nematode cuticle collagen, N-terminal | Nematode cuticle collagen, N-terminal | Col_cuticle_N | 5 |
IPR002487 | 2,487 | Transcription factor, K-box | TF_Kbox | Domain | 29,186 | false | false | MADS genes in plants encode key developmental regulators of vegetative and reproductive development. The majority of the plant MADS proteins share a stereotypical MIKC structure. It comprises (from N- to C-terminal) an N-terminal domain, which is, however, present only in a minority of proteins; a MADS domain (see , ),... | [
"GO:0003700",
"GO:0006355",
"GO:0005634"
] | [
"DNA-binding transcription factor activity",
"regulation of DNA-templated transcription",
"nucleus"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PROFILE"
] | [
"PF01486",
"PS51297"
] | [
"K-box",
"K_BOX"
] | [
28960,
28237
] | 2 | [] | [] | [] | 0 | [
"4ox0",
"7xgs",
"8cra"
] | 3 | [
"PUB00043748",
"PUB00043749",
"PUB00043750"
] | [
"10805792",
"12032236",
"12943540"
] | [
"An ancestral MADS-box gene duplication occurred before the divergence of plants and animals.",
"Two ancient classes of MIKC-type MADS-box genes are present in the moss Physcomitrella patens.",
"The K domain mediates heterodimerization of the Arabidopsis floral organ identity proteins, APETALA3 and PISTILLATA."... | [
2000,
2002,
2003
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Salinivibrio costicola"
] | [
29185,
1
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
277,
81,
311
] | 3 | true | Domain | Transcription factor, K-box | Transcription factor, K-box | TF_Kbox | 2 |
IPR002488 | 2,488 | Geminivirus C4 protein | Gemini_C4 | Family | 3,697 | false | false | This family consists of the N-terminal region of geminivirus C4 or AC4 proteins. In Tomato yellow leaf curl virus the C4 protein is necessary for efficient spreading of the virus in Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01492"
] | [
"Gemini_C4"
] | [
3697
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00005601"
] | [
"8091687"
] | [
"Movement of tomato yellow leaf curl geminivirus (TYLCV): involvement of the protein encoded by ORF C4."
] | [
1994
] | 1 | [] | [] | 0 | 0 | null | [
"Cotton leaf curl Rajasthan virus defective interfering DNA",
"Pentapetalae",
"Viruses"
] | [
2,
4,
3691
] | 3 | [] | [] | 0 | true | Family | Geminivirus C4 protein | Geminivirus C4 protein | Gemini_C4 | 2 |
IPR002489 | 2,489 | Glutamate synthase, alpha subunit, C-terminal | Glu_synth_asu_C | Domain | 29,680 | false | false | Glutamate synthase (GltS) is a complex iron-sulphur flavoprotein that catalyses the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the bacterial, yeast and plant pathways for ammonia assimilation [ ]. GltS is a multifunctional enzyme that ... | [
"GO:0016491"
] | [
"oxidoreductase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"CDD"
] | [
"PF01493",
"cd00982"
] | [
"GXGXG",
"gltB_C"
] | [
29677,
25255
] | 2 | [] | [] | [] | 0 | [
"1ea0",
"1llw",
"1llz",
"1lm1",
"1ofd",
"1ofe",
"2vdc",
"6s6s",
"6s6t",
"6s6u",
"6s6x",
"7mfm",
"7mft"
] | 13 | [
"PUB00000170",
"PUB00008698",
"PUB00013982"
] | [
"9818358",
"11967268",
"11188694"
] | [
"The formylmethanofuran dehydrogenase isoenzymes in Methanobacterium wolfei and Methanobacterium thermoautotrophicum: induction of the molybdenum isoenzyme by molybdate and constitutive synthesis of the tungsten isoenzyme.",
"Structural studies on the synchronization of catalytic centers in glutamate synthase.",
... | [
1998,
2002,
2000
] | 3 | [] | [
"IPR017550"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
738,
23062,
5299,
581
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosacchar... | [
13,
2,
4,
1,
1,
8,
1,
1,
93
] | 9 | true | Domain | Glutamate synthase, alpha subunit, C-terminal | Glutamate synthase, alpha subunit, C-terminal | Glu_synth_asu_C | 8 |
IPR002491 | 2,491 | ABC transporter periplasmic binding domain | ABC_transptr_periplasmic_BD | Domain | 96,503 | false | false | ATP binding cassette (ABC) transporters are a ubiquitous family of importer and exporter proteins that consist of two α-helical transmembrane (TM) domains, which form a translocation pathway, and two cytoplasmic ABC domains, which power the transport reaction through binding and hydrolysis of ATP. In addition most bact... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE"
] | [
"PF01497",
"PS50983"
] | [
"Peripla_BP_2",
"FE_B12_PBP"
] | [
94985,
94145
] | 2 | [
"PROSITEDOC",
"REACTOME",
"REACTOME"
] | [
"PDOC50983",
"R-HSA-9638334",
"R-HSA-9638482"
] | [
"PROSITEDOC:PDOC50983",
"REACTOME:R-HSA-9638334",
"REACTOME:R-HSA-9638482"
] | 3 | [
"1efd",
"1esz",
"1k2v",
"1k7s",
"1n2z",
"1n4a",
"1n4d",
"2chu",
"2etv",
"2m6k",
"2m6l",
"2phz",
"2q8p",
"2q8q",
"2qi9",
"2r79",
"2r7a",
"2rg7",
"2why",
"2wi8",
"2x4l",
"2xuz",
"2xv1",
"3be5",
"3be6",
"3eiw",
"3eix",
"3g9q",
"3gfv",
"3hxp",
"3lhs",
"3li2"... | 141 | [
"PUB00002077",
"PUB00015402",
"PUB00015423",
"PUB00018445"
] | [
"2651410",
"12468528",
"12475936",
"14514690"
] | [
"Nucleotide sequences of the fecBCDE genes and locations of the proteins suggest a periplasmic-binding-protein-dependent transport mechanism for iron(III) dicitrate in Escherichia coli.",
"Crystal structures of the BtuF periplasmic-binding protein for vitamin B12 suggest a functionally important reduction in prot... | [
1989,
2003,
2002,
2003
] | 4 | [] | [
"IPR033870"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
3852,
91332,
478,
1,
840
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)"
] | [
1,
4
] | 2 | true | Domain | ABC transporter periplasmic binding domain | ABC transporter periplasmic binding domain | ABC_transptr_periplasmic_BD | 9 |
IPR002493 | 2,493 | Herpesvirus UL25 | Herpes_UL25 | Family | 570 | false | false | The herpes simplex virus 1 (HSV-1) UL25 is a minor capsid component that is required for encapsidation, but not cleavage, of replicated viral DNA [ ]. It may function to stabilize capsids that contain full-length viral genomes [ ]. | [
"GO:0019072",
"GO:0019028"
] | [
"viral genome packaging",
"viral capsid"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"HAMAP",
"PFAM"
] | [
"MF_04025",
"PF01499"
] | [
"HSV_CVC2",
"Herpes_UL25"
] | [
429,
570
] | 2 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-9609690",
"R-HSA-9610379"
] | [
"REACTOME:R-HSA-9609690",
"REACTOME:R-HSA-9610379"
] | 2 | [
"2f5u",
"5zz8",
"6cgr",
"6m6g",
"6m6h",
"6odm",
"6ppb",
"6pph",
"6w2d",
"6w2e",
"7bqx",
"7br7",
"7et3",
"7etj",
"7eto",
"7fj1",
"7nxp",
"7nxq",
"7nxr",
"8hex",
"8hey",
"8tep",
"8tes",
"8tet",
"8teu",
"8tew",
"8x9w",
"8xa0",
"9no1"
] | 29 | [
"PUB00094711",
"PUB00094712"
] | [
"18945788",
"21411517"
] | [
"Role of the UL25 protein in herpes simplex virus DNA encapsidation.",
"Residues of the UL25 protein of herpes simplex virus that are required for its stable interaction with capsids."
] | [
2009,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Homo sapiens",
"Orthoherpesviridae"
] | [
1,
569
] | 2 | [
"Homo sapiens"
] | [
1
] | 1 | true | Family | Herpesvirus UL25 | Herpesvirus UL25 | Herpes_UL25 | 3 |
IPR002494 | 2,494 | Keratin-associated protein | KAP | Family | 4,219 | false | false | Keratin-associated proteins (KAPs) are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments [ , ]. This entry also includes the high-sulfur and high-tyrosine keratins from sheep and goats. In the hair cortex, hai... | [
"GO:0045095"
] | [
"keratin filament"
] | [
"cellular_component"
] | 1 | [
"PFAM",
"PFAM"
] | [
"PF01500",
"PF13885"
] | [
"Keratin_B2",
"Keratin_B2_2"
] | [
980,
3342
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-6805567",
"R-HSA-6805567",
"R-MMU-6805567"
] | [
"REACTOME:R-BTA-6805567",
"REACTOME:R-HSA-6805567",
"REACTOME:R-MMU-6805567"
] | 3 | [] | 0 | [
"PUB00001880",
"PUB00059267",
"PUB00070113"
] | [
"9524245",
"2250030",
"14962103"
] | [
"Structure and hair follicle-specific expression of genes encoding the rat high sulfur protein B2 family.",
"Serine-rich ultra high sulfur protein gene expression in murine hair and skin during the hair cycle.",
"Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human... | [
1998,
1990,
2004
] | 3 | [] | [
"IPR052154"
] | 0 | 1 | 0 | [
"Bacteria",
"Megavirus",
"Opisthokonta"
] | [
6,
3,
4210
] | 3 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
54,
60,
51
] | 3 | true | Family | Keratin-associated protein | Keratin-associated protein | KAP | 7 |
IPR002495 | 2,495 | Glycosyl transferase, family 8 | Glyco_trans_8 | Family | 54,234 | false | false | This entry represents Glycosyltransferase family 8. Glycosyltransferase family 8 comprises enzymes with a number of known activities; lipopolysaccharide galactosyltransferase ( ), lipopolysaccharide glucosyltransferase 1 ( ), glycogenin glucosyltransferase ( ), inositol 1-α-galactosyltransferase ( ), α-1,3-xylosyltrans... | [
"GO:0016757"
] | [
"glycosyltransferase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF01501"
] | [
"Glyco_transf_8"
] | [
54234
] | 1 | [
"CAZY",
"EC",
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"R... | [
"GT8",
"2.4.1",
"GenProp1483",
"GenProp1651",
"R-CEL-3322077",
"R-CEL-6798695",
"R-CEL-70221",
"R-DRE-9939291",
"R-HSA-3322077",
"R-HSA-3785653",
"R-HSA-3814836",
"R-HSA-3828062",
"R-HSA-3858516",
"R-HSA-3878781",
"R-HSA-5083627",
"R-HSA-5357609",
"R-HSA-6798695",
"R-HSA-70221",
... | [
"CAZY:GT8",
"EC:2.4.1",
"GP:GenProp1483",
"GP:GenProp1651",
"REACTOME:R-CEL-3322077",
"REACTOME:R-CEL-6798695",
"REACTOME:R-CEL-70221",
"REACTOME:R-DRE-9939291",
"REACTOME:R-HSA-3322077",
"REACTOME:R-HSA-3785653",
"REACTOME:R-HSA-3814836",
"REACTOME:R-HSA-3828062",
"REACTOME:R-HSA-3858516",
... | 33 | [
"1g9r",
"1ga8",
"1ll0",
"1ll2",
"1ll3",
"1ss9",
"1zct",
"1zcu",
"1zcv",
"1zcy",
"1zdf",
"1zdg",
"3q4s",
"3qvb",
"3rmv",
"3rmw",
"3t7m",
"3t7n",
"3t7o",
"3tzt",
"3u2t",
"3u2u",
"3u2v",
"3u2w",
"3u2x",
"3usq",
"3usr",
"3v8y",
"3v8z",
"3v90",
"3v91",
"4ueg"... | 62 | [
"PUB00009409",
"PUB00100246"
] | [
"9334165",
"22223806"
] | [
"A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities.",
"Dystroglycan function requires xylosyl- and glucuronyltransferase activities of LARGE."
] | [
1997,
2012
] | 2 | [] | [
"IPR029993"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Methanobacteriati",
"Viruses",
"unclassified sequences"
] | [
12245,
41710,
23,
132,
124
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
206,
3,
29,
9,
2,
43,
20,
3,
111,
36,
2,
1,
234
] | 13 | true | Family | Glycosyl transferase, family 8 | Glycosyl transferase, family 8 | Glyco_trans_8 | 2 |
IPR002496 | 2,496 | Phosphoribosyl-AMP cyclohydrolase domain | PRib_AMP_CycHydrolase_dom | Domain | 26,295 | false | false | The phosphoribosyl-AMP cyclohydrolase catalyses the third step in the histidine (his) biosynthetic pathway: 5-phosphoribosyl-AMP H 2 O = 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phospho-ribosyl) imidazole-4-carboxamide It requires Zn 2 ions for activity [ ]. | [
"GO:0004635",
"GO:0000105"
] | [
"phosphoribosyl-AMP cyclohydrolase activity",
"L-histidine biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF01502"
] | [
"PRA-CH"
] | [
26295
] | 1 | [
"EC",
"GP"
] | [
"3.5.4.19",
"GenProp0109"
] | [
"EC:3.5.4.19",
"GP:GenProp0109"
] | 2 | [
"1zps",
"6j22",
"6j2l",
"7bgm",
"7bgn"
] | 5 | [
"PUB00000456"
] | [
"9931020"
] | [
"N1-(5'-phosphoribosyl)adenosine-5'-monophosphate cyclohydrolase: purification and characterization of a unique metalloenzyme."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
811,
22189,
2765,
7,
523
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
7,
1,
1,
2,
1,
1,
4
] | 7 | true | Domain | Phosphoribosyl-AMP cyclohydrolase domain | Phosphoribosyl-AMP cyclohydrolase domain | PRib_AMP_CycHydrolase_dom | 2 |
IPR002498 | 2,498 | Phosphatidylinositol-4-phosphate 4/5-kinase, core | PInositol-4-P-4/5-kinase_core | Domain | 34,652 | false | false | This entry represents a conserved region from the common kinase core found in the type I phosphatidylinositol-4-phosphate 4 and 5-kinases (PIP4K/PIP5K) family as described in [ ]. This region is found in I, II and III phosphatidylinositol-4-phosphate 5-kinases (PIP5K enzymes). PIP5K catalyses the formation of phosphoin... | [
"GO:0052742",
"GO:0046488"
] | [
"phosphatidylinositol kinase activity",
"phosphatidylinositol metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF01504",
"PS51455",
"SM00330"
] | [
"PIP5K",
"PIPK",
"PIPKc"
] | [
34412,
34272,
33532
] | 3 | [
"EC",
"GP",
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REA... | [
"2.7.1",
"GenProp1511",
"GenProp1548",
"GenProp1758",
"R-BTA-1660499",
"R-BTA-6811555",
"R-BTA-6811558",
"R-BTA-8847453",
"R-DDI-1660499",
"R-DDI-6811555",
"R-DDI-6811558",
"R-DDI-8847453",
"R-DDI-8856828",
"R-DME-1660499",
"R-DME-201688",
"R-DME-6811558",
"R-DRE-1660499",
"R-DRE-6... | [
"EC:2.7.1",
"GP:GenProp1511",
"GP:GenProp1548",
"GP:GenProp1758",
"REACTOME:R-BTA-1660499",
"REACTOME:R-BTA-6811555",
"REACTOME:R-BTA-6811558",
"REACTOME:R-BTA-8847453",
"REACTOME:R-DDI-1660499",
"REACTOME:R-DDI-6811555",
"REACTOME:R-DDI-6811558",
"REACTOME:R-DDI-8847453",
"REACTOME:R-DDI-88... | 69 | [
"1bo1",
"2gk9",
"2ybx",
"3wzz",
"3x01",
"3x02",
"3x03",
"3x04",
"3x05",
"3x06",
"3x07",
"3x08",
"3x09",
"3x0a",
"3x0b",
"3x0c",
"4tz7",
"5e3s",
"5e3t",
"5e3u",
"6cmw",
"6cn2",
"6cn3",
"6k4g",
"6k4h",
"6osp",
"6ux9",
"6ym3",
"6ym4",
"6ym5",
"7em1",
"7em2"... | 54 | [
"PUB00003041",
"PUB00097036",
"PUB00101345",
"PUB00133528",
"PUB00133529",
"PUB00153073",
"PUB00153074",
"PUB00153075",
"PUB00153076"
] | [
"9535851",
"21412048",
"22942276",
"9811604",
"16492811",
"23326584",
"31091439",
"16837550",
"24807078"
] | [
"Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family.",
"Arabidopsis FAB1A/B is possibly involved in the recycling of auxin transporters.",
"Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl... | [
1998,
2011,
2012,
1998,
2006,
2013,
2019,
2006,
2014
] | 9 | [] | [
"IPR044769"
] | 0 | 1 | 0 | [
"Eukaryota",
"Reinekea marinisedimentorum",
"organismal metagenomes"
] | [
34649,
1,
2
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
77,
4,
44,
12,
30,
19,
3,
65,
35,
2,
2,
174
] | 12 | true | Domain | Phosphatidylinositol-4-phosphate 4/5-kinase, core | Phosphatidylinositol-4-phosphate 4/5-kinase, core | PInositol-4-P-4/5-kinase_core | 4 |
IPR002499 | 2,499 | Major vault protein, N-terminal | Vault_N | Repeat | 1,882 | false | false | Vaults are the largest ribonucleoprotein particles known, having a mass of approximately 13 MDa. They are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction and may also play a role in nucleo-cytoplasmic transport. Vaults are present in most normal tissues, but are more high... | [] | [] | [] | 0 | [
"PROFILE"
] | [
"PS51224"
] | [
"MVP"
] | [
1882
] | 1 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC51224",
"R-DDI-6798695",
"R-DRE-6798695",
"R-HSA-6798695",
"R-MMU-6798695",
"R-RNO-6798695"
] | [
"PROSITEDOC:PDOC51224",
"REACTOME:R-DDI-6798695",
"REACTOME:R-DRE-6798695",
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-6798695",
"REACTOME:R-RNO-6798695"
] | 6 | [
"1y7x",
"2qzv",
"3gf5",
"3gnf",
"3gng",
"4hl8",
"4v60",
"6bp7",
"6bp8",
"7pkr",
"7pky",
"7pkz",
"9bw5",
"9bw6",
"9bw7",
"9mxh",
"9mxj",
"9mxv",
"9r86",
"9r87"
] | 20 | [
"PUB00005308",
"PUB00035318",
"PUB00035319"
] | [
"10196123",
"16918321",
"16373071"
] | [
"Structure of the vault, a ubiquitous celular component.",
"Cellular functions of vaults and their involvement in multidrug resistance.",
"Solution structure of a two-repeat fragment of major vault protein."
] | [
1999,
2006,
2006
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Lokiarchaeum ossiferum",
"Eukaryota"
] | [
35,
1,
1846
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
16,
5,
3
] | 4 | true | Repeat | Major vault protein, N-terminal | Major vault protein, N-terminal | Vault_N | 7 |
IPR002500 | 2,500 | Phosphoadenosine phosphosulphate reductase domain | PAPS_reduct_dom | Domain | 51,911 | false | false | This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases [ ]. A highly modified version of the P loop, the fingerprint peptide of monon... | [
"GO:0003824"
] | [
"catalytic activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF01507"
] | [
"PAPS_reduct"
] | [
51911
] | 1 | [
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"GenProp1764",
"R-CEL-196843",
"R-DRE-196843",
"R-HSA-196843",
"R-MMU-196843",
"R-MTU-936635",
"R-MTU-936721",
"R-SCE-196843",
"R-SPO-196843"
] | [
"GP:GenProp1764",
"REACTOME:R-CEL-196843",
"REACTOME:R-DRE-196843",
"REACTOME:R-HSA-196843",
"REACTOME:R-MMU-196843",
"REACTOME:R-MTU-936635",
"REACTOME:R-MTU-936721",
"REACTOME:R-SCE-196843",
"REACTOME:R-SPO-196843"
] | 9 | [
"1sur",
"1zun",
"2goy",
"2o8v",
"2oq2",
"2wsi",
"3fwk",
"3g59",
"3g5a",
"3g6k",
"4bwv",
"4kkv",
"6vpu",
"7lhr",
"7lhs",
"7lhu",
"7rge",
"8rom",
"8ron"
] | 19 | [
"PUB00001462",
"PUB00004086",
"PUB00005294"
] | [
"7588765",
"2250719",
"9261082"
] | [
"Reaction mechanism of thioredoxin: 3'-phospho-adenylylsulfate reductase investigated by site-directed mutagenesis.",
"ATP sulphurylase activity of the nodP and nodQ gene products of Rhizobium meliloti.",
"Crystal structure of phosphoadenylyl sulphate (PAPS) reductase: a new family of adenine nucleotide alpha h... | [
1995,
1990,
1997
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1302,
41462,
8094,
282,
771
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
20,
3,
7,
4,
3,
2,
1,
2,
5,
3,
2,
2,
22
] | 13 | true | Domain | Phosphoadenosine phosphosulphate reductase domain | Phosphoadenosine phosphosulphate reductase domain | PAPS_reduct_dom | 4 |
IPR002501 | 2,501 | Pseudouridine synthase II, N-terminal | PsdUridine_synth_N | Domain | 37,242 | false | false | This entry represents an N-terminal domain found in pseudouridine synthase TruB, as well as Cbf5p that modifies rRNA [ ]. TruB is found in all domains of life and it is responsible for the pseudouridine residue present in the T loops of virtually all tRNAs. TruB recognises the preformed 3D structure of the T loop prima... | [
"GO:0006396"
] | [
"RNA processing"
] | [
"biological_process"
] | 1 | [
"PFAM"
] | [
"PF01509"
] | [
"TruB_N"
] | [
37242
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"5.4.99.25",
"R-CEL-171319",
"R-DDI-171319",
"R-DME-171319",
"R-GGA-417076",
"R-HSA-171319",
"R-HSA-6790901",
"R-HSA-6793080",
"R-HSA-9937008",
"R-MMU-171319",
"R-RNO-171319",
"R-SCE-171319",
"R-SPO-171319"
] | [
"EC:5.4.99.25",
"REACTOME:R-CEL-171319",
"REACTOME:R-DDI-171319",
"REACTOME:R-DME-171319",
"REACTOME:R-GGA-417076",
"REACTOME:R-HSA-171319",
"REACTOME:R-HSA-6790901",
"REACTOME:R-HSA-6793080",
"REACTOME:R-HSA-9937008",
"REACTOME:R-MMU-171319",
"REACTOME:R-RNO-171319",
"REACTOME:R-SCE-171319",
... | 13 | [
"1k8w",
"1r3e",
"1r3f",
"1sgv",
"1ze1",
"1ze2",
"1zl3",
"2ab4",
"2apo",
"2aus",
"2ey4",
"2hvy",
"2rfk",
"3hax",
"3hay",
"3hjw",
"3hjy",
"3lwo",
"3lwp",
"3lwq",
"3lwr",
"3lwv",
"3mqk",
"3u28",
"3uai",
"7bgb",
"7trc",
"7v9a",
"8jfx",
"8oue",
"8ouf",
"9g25"... | 35 | [
"PUB00001931",
"PUB00026665",
"PUB00045922",
"PUB00092579"
] | [
"9472021",
"11779468",
"10529181",
"19664587"
] | [
"The box H + ACA snoRNAs carry Cbf5p, the putative rRNA pseudouridine synthase.",
"Cocrystal structure of a tRNA Psi55 pseudouridine synthase: nucleotide flipping by an RNA-modifying enzyme.",
"Role of cysteine residues in pseudouridine synthases of different families.",
"Enzymatic characterization and mutati... | [
1998,
2001,
1999,
2009
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
915,
25402,
10297,
10,
618
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
11,
1,
5,
6,
1,
18,
12,
2,
15,
18,
2,
2,
11
] | 13 | true | Domain | Pseudouridine synthase II, N-terminal | Pseudouridine synthase II, N-terminal | PsdUridine_synth_N | 1 |
IPR002502 | 2,502 | N-acetylmuramoyl-L-alanine amidase domain | Amidase_domain | Domain | 51,092 | false | false | Proteins containing this domain include zinc amidases that have N-acetylmuramoyl-L-alanine amidase activity . This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls (preferentially: D-lactyl-L-Ala). The bacteriophage endolysins PLY118 and PLY500 cleave between L-Ala... | [
"GO:0008745",
"GO:0009253"
] | [
"N-acetylmuramoyl-L-alanine amidase activity",
"peptidoglycan catabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"SMART",
"CDD"
] | [
"PF01510",
"SM00644",
"cd06583"
] | [
"Amidase_2",
"Ami_2",
"PGRP"
] | [
49880,
43348,
48120
] | 3 | [
"EC",
"GP",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.5.1.28",
"GenProp1623",
"PWY-7883",
"R-BTA-6798695",
"R-BTA-6803157",
"R-DME-209171",
"R-DME-209266",
"R-DME-214397",
"R-DME-214399",
"R-DME-214411",
"R-DME-214416",
"R-DME-6798695",
"R-DME-6803157",
"R-HSA-6798695",
"R-HSA-6803157",
"R-MMU-6798695",
"R-MMU-6803157",
"R-RNO-6798... | [
"EC:3.5.1.28",
"GP:GenProp1623",
"METACYC:PWY-7883",
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-6803157",
"REACTOME:R-DME-209171",
"REACTOME:R-DME-209266",
"REACTOME:R-DME-214397",
"REACTOME:R-DME-214399",
"REACTOME:R-DME-214411",
"REACTOME:R-DME-214416",
"REACTOME:R-DME-6798695",
"REACTOME:R... | 19 | [
"1aro",
"1j3g",
"1lba",
"1oht",
"1s2j",
"1sk3",
"1sk4",
"1sxr",
"1twq",
"1yb0",
"1yck",
"1z6i",
"2aph",
"2ar3",
"2bh7",
"2cb3",
"2eav",
"2eax",
"2f2l",
"2l47",
"2r2k",
"2r90",
"2rkq",
"2wkx",
"2xz4",
"2xz8",
"2y28",
"2y2b",
"2y2c",
"2y2d",
"2y2e",
"2z9n"... | 103 | [
"PUB00004839",
"PUB00020090",
"PUB00029445",
"PUB00031088",
"PUB00031236",
"PUB00038465",
"PUB00040509",
"PUB00047175",
"PUB00049410",
"PUB00079661"
] | [
"8171031",
"8577256",
"12845326",
"15140887",
"15223330",
"16103125",
"16556841",
"16428381",
"18304640",
"14506276"
] | [
"The structure of bacteriophage T7 lysozyme, a zinc amidase and an inhibitor of T7 RNA polymerase.",
"Heterogeneous endolysins in Listeria monocytogenes bacteriophages: a new class of enzymes and evidence for conserved holin genes within the siphoviral lysis cassettes.",
"Crystal structure of peptidoglycan reco... | [
1994,
1995,
2003,
2004,
2004,
2005,
2006,
2006,
2008,
2003
] | 10 | [] | [
"IPR006619"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
48,
41121,
6924,
2566,
433
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
7,
36,
2,
4,
10,
15
] | 7 | true | Domain | N-acetylmuramoyl-L-alanine amidase domain | N-acetylmuramoyl-L-alanine amidase domain | Amidase_domain | 7 |
IPR002504 | 2,504 | NAD kinase | NADK | Family | 42,046 | false | false | Members of this family are NAD kinases . The enzymes catalyse the phosphorylation of NAD to NADP utilizing ATP and other nucleoside triphosphates, as well as inorganic polyphosphate, as a source of phosphorus. Such enzymes are thus designated poly(P)/ATP-NAD kinases [ ]. NAD kinase is one of the key enzymes regulating ... | [
"GO:0006741"
] | [
"NADP+ biosynthetic process"
] | [
"biological_process"
] | 1 | [
"HAMAP",
"PFAM"
] | [
"MF_00361",
"PF01513"
] | [
"NAD_kinase",
"NAD_kinase"
] | [
35700,
40230
] | 2 | [
"EC",
"EC",
"GP",
"GP",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.1",
"2.7.1.23",
"GenProp0057",
"GenProp1305",
"GenProp1502",
"GenProp1677",
"PWY-5083",
"PWY-7268",
"PWY-7269",
"PWY-8148",
"R-HSA-196807",
"R-HSA-9837999",
"R-MMU-196807",
"R-MMU-9837999",
"R-RNO-196807",
"R-RNO-9837999",
"R-SCE-196807",
"R-SPO-196807",
"R-XTR-196807"
] | [
"EC:2.7.1",
"EC:2.7.1.23",
"GP:GenProp0057",
"GP:GenProp1305",
"GP:GenProp1502",
"GP:GenProp1677",
"METACYC:PWY-5083",
"METACYC:PWY-7268",
"METACYC:PWY-7269",
"METACYC:PWY-8148",
"REACTOME:R-HSA-196807",
"REACTOME:R-HSA-9837999",
"REACTOME:R-MMU-196807",
"REACTOME:R-MMU-9837999",
"REACTO... | 19 | [
"1suw",
"1u0r",
"1u0t",
"1y3h",
"1y3i",
"1yt5",
"1z0s",
"1z0u",
"1z0z",
"2an1",
"2i1w",
"2i29",
"2i2a",
"2i2b",
"2i2c",
"2i2d",
"2i2f",
"2q5f",
"3afo",
"3pfn",
"3v7u",
"3v7w",
"3v7y",
"3v80",
"3v8m",
"3v8n",
"3v8p",
"3v8q",
"3v8r",
"4dy6",
"4hao",
"5dhp"... | 119 | [
"PUB00027720",
"PUB00070138"
] | [
"11006082",
"22056937"
] | [
"Inorganic Polyphosphate/ATP-NAD kinase of Micrococcus flavus and Mycobacterium tuberculosis H37Rv.",
"The cyanobacterial NAD kinase gene sll1415 is required for photoheterotrophic growth and cellular redox homeostasis in Synechocystis sp. strain PCC 6803."
] | [
2000,
2012
] | 2 | [] | [
"IPR012355",
"IPR021175",
"IPR039065"
] | 0 | 3 | 0 | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
1724,
27496,
2,
12175,
649
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
17,
3,
6,
11,
1,
6,
10,
3,
10,
11,
3,
4,
27
] | 13 | true | Family | NAD kinase | NAD kinase | NADK | 1 |
IPR002506 | 2,506 | Hepatitis delta virus delta antigen | HDV_ag | Family | 2,194 | false | false | The Hepatitis delta virus (HDV) encodes a single protein, the hepatitis delta antigen (HDAg). The central region of this protein has been shown to bind RNA [ ]. Several interactions are also mediated by a coiled-coil region at the N terminus of the protein [ ]. | [
"GO:0003723",
"GO:0046718"
] | [
"RNA binding",
"symbiont entry into host cell"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF01517"
] | [
"HDV_ag"
] | [
2194
] | 1 | [] | [] | [] | 0 | [
"1a92",
"1by0",
"9flg"
] | 3 | [
"PUB00003153",
"PUB00005306"
] | [
"8245865",
"9687364"
] | [
"Characterization of RNA-binding domains of hepatitis delta antigen.",
"Structural basis of the oligomerization of hepatitis delta antigen."
] | [
1993,
1998
] | 2 | [] | [] | 0 | 0 | null | [
"Kolmioviridae"
] | [
2194
] | 1 | [] | [] | 0 | true | Family | Hepatitis delta virus delta antigen | Hepatitis delta virus delta antigen | HDV_ag | 2 |
IPR002508 | 2,508 | N-acetylmuramoyl-L-alanine amidase, catalytic domain | MurNAc-LAA_cat | Domain | 45,032 | false | false | N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino acids in certain cell wall glycopeptides. These proteins are Zn-dependent peptida... | [
"GO:0008745",
"GO:0009253"
] | [
"N-acetylmuramoyl-L-alanine amidase activity",
"peptidoglycan catabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"SMART",
"CDD"
] | [
"PF01520",
"SM00646",
"cd02696"
] | [
"Amidase_3",
"Ami_3",
"MurNAc-LAA"
] | [
45018,
42764,
44198
] | 3 | [
"EC"
] | [
"3.5.1"
] | [
"EC:3.5.1"
] | 1 | [
"1jwq",
"1xov",
"3czx",
"3ne8",
"3qay",
"4bin",
"4lq6",
"4m6g",
"4m6h",
"4m6i",
"4rn7",
"5emi",
"5j72",
"7agl",
"7agm",
"7ago",
"7b3n",
"7rag",
"7tj4",
"8c0j",
"8c2o",
"9cun",
"9jzo"
] | 23 | [
"PUB00079652",
"PUB00079656",
"PUB00079664"
] | [
"18266855",
"16855223",
"23927005"
] | [
"Bacterial peptidoglycan (murein) hydrolases.",
"Daughter cell separation by penicillin-binding proteins and peptidoglycan amidases in Escherichia coli.",
"The crystal structure of the cell division amidase AmiC reveals the fold of the AMIN domain, a new peptidoglycan binding domain."
] | [
2008,
2006,
2013
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
12,
43924,
63,
358,
675
] | 5 | [
"Escherichia coli (strain K12)"
] | [
4
] | 1 | true | Domain | N-acetylmuramoyl-L-alanine amidase, catalytic domain | N-acetylmuramoyl-L-alanine amidase, catalytic domain | MurNAc-LAA_cat | 7 |
IPR002509 | 2,509 | NodB homology domain | NODB_dom | Domain | 112,723 | false | false | The NodB homology domain is a catalytic domain of ~200 amino acid residues, which has been named after its similarity to rhizobial NodB chitooligosaccharide deacetylase. It is found in members of carbohydrate esterase family 4 (CE4) and in PuuE proteins. Members of the CE4 family exhibit metal-dependent deacetylation o... | [
"GO:0016810",
"GO:0005975"
] | [
"hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds",
"carbohydrate metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PROFILE"
] | [
"PF01522",
"PS51677"
] | [
"Polysacc_deac_1",
"NODB"
] | [
111940,
101580
] | 2 | [
"GP"
] | [
"GenProp1722"
] | [
"GP:GenProp1722"
] | 1 | [
"1ny1",
"1w17",
"1w1a",
"1w1b",
"1z7a",
"2c1g",
"2c1i",
"2c71",
"2c79",
"2cc0",
"2iw0",
"2j13",
"2vyo",
"2w3z",
"2y8u",
"3cl6",
"3cl7",
"3cl8",
"3qbu",
"3rxz",
"3s6o",
"3vus",
"3wx7",
"4f9d",
"4f9j",
"4hd5",
"4l1g",
"4ly4",
"4m1b",
"4ny2",
"4nyu",
"4nyy"... | 81 | [
"PUB00038008",
"PUB00050032",
"PUB00051042",
"PUB00058910",
"PUB00075308"
] | [
"15251431",
"18978064",
"18550550",
"21559431",
"12644381"
] | [
"Structures of Bacillus subtilis PdaA, a family 4 carbohydrate esterase, and a complex with N-acetyl-glucosamine.",
"Streptococcus mutans SMU.623c codes for a functional, metal-dependent polysaccharide deacetylase that modulates interactions with salivary agglutinin.",
"Logical identification of an allantoinase... | [
2004,
2009,
2008,
2011,
2003
] | 5 | [] | [
"IPR017625"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1324,
93057,
17244,
40,
1058
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (st... | [
2,
8,
12,
3,
1,
5,
2,
1
] | 8 | true | Domain | NodB homology domain | NodB homology domain | NODB_dom | 1 |
IPR002511 | 2,511 | Geminivirus V2 protein | Gemini_V2 | Family | 3,238 | false | false | Disruption of the V2 gene in Tomato yellow leaf curl virus (TYLCV) stopped its ability to systemically infect Solanum lycopersicum (Tomato) (Lycopersicon esculentum) plants, suggesting that the V2 gene product is required for successful infection of the host [ ]. | [
"GO:0044003",
"GO:0060967",
"GO:0030430"
] | [
"symbiont-mediated perturbation of host process",
"negative regulation of gene silencing by regulatory ncRNA",
"host cell cytoplasm"
] | [
"biological_process",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM"
] | [
"PF01524"
] | [
"Gemini_V2"
] | [
3238
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00005619"
] | [
"9123819"
] | [
"Genetic analysis of the monopartite tomato yellow leaf curl geminivirus: roles of V1, V2, and C2 ORFs in viral pathogenesis."
] | [
1997
] | 1 | [] | [] | 0 | 0 | null | [
"Hibiscus sabdariffa",
"Nostoc flagelliforme CCNUN1",
"Viruses"
] | [
1,
1,
3236
] | 3 | [] | [] | 0 | true | Family | Geminivirus V2 protein | Geminivirus V2 protein | Gemini_V2 | 9 |
IPR002512 | 2,512 | Rotavirus A/C, non-structural protein 5 | Rotavirus_A/C_NSP5 | Family | 2,714 | false | false | Rotaviruses are dsRNA viruses that appear to infect a wide range of mammals. Gene 11 product is a non-structural phosphoprotein designated as NS26, now more commonly annotated as non-structural protein 5 (NSP5) [ ]. | [
"GO:0000287",
"GO:0016887",
"GO:0019079",
"GO:0030430"
] | [
"magnesium ion binding",
"ATP hydrolysis activity",
"viral genome replication",
"host cell cytoplasm"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"HAMAP",
"PFAM",
"PIRSF"
] | [
"MF_04092",
"PF01525",
"PIRSF004006"
] | [
"ROTA_NSP5",
"Rota_NS26",
"Rota_NS26"
] | [
2544,
2688,
2630
] | 3 | [] | [] | [] | 0 | [] | 0 | [
"PUB00003485"
] | [
"2548010"
] | [
"Rotavirus SA11 genome segment 11 protein is a nonstructural phosphoprotein."
] | [
1989
] | 1 | [] | [] | 0 | 0 | null | [
"Chryseobacterium kimseyorum",
"Rotavirus"
] | [
1,
2713
] | 2 | [] | [] | 0 | true | Family | Rotavirus A/C, non-structural protein 5 | Rotavirus A/C, non-structural protein 5 | Rotavirus_A/C_NSP5 | 3 |
IPR002514 | 2,514 | Transposase IS3/IS911family | Transposase_8 | Family | 60,482 | false | false | Transposase proteins are necessary for efficient DNA transposition. This family consists of various Escherichia coli insertion elements and other bacterial transposases some of which are members of the IS3 family. This region includes a helix-turn-helix motif (HTH) at the N terminus followed by a leucine zipper (LZ) mo... | [
"GO:0003677",
"GO:0004803",
"GO:0006313"
] | [
"DNA binding",
"transposase activity",
"DNA transposition"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM"
] | [
"PF01527"
] | [
"HTH_Tnp_1"
] | [
60482
] | 1 | [] | [] | [] | 0 | [
"2jn6",
"2rn7"
] | 2 | [
"PUB00006157"
] | [
"9761671"
] | [
"Multiple oligomerisation domains in the IS911 transposase: a leucine zipper motif is essential for activity."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"plasmids",
"unclassified sequences"
] | [
68,
59092,
413,
98,
2,
809
] | 6 | [
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica"
] | [
21,
3
] | 2 | true | Family | Transposase IS3/IS911family | Transposase IS3/IS911family | Transposase_8 | 2 |
IPR002515 | 2,515 | Zinc finger, C2H2C-type | Znf_C2H2C | Repeat | 13,179 | false | false | null | [
"GO:0008270",
"GO:0006355",
"GO:0005634"
] | [
"zinc ion binding",
"regulation of DNA-templated transcription",
"nucleus"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PROFILE"
] | [
"PF01530",
"PS51802"
] | [
"zf-C2HC",
"ZF_CCHHC"
] | [
12221,
13158
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-3214847",
"R-HSA-6804760",
"R-MMU-3214847",
"R-MMU-6804760",
"R-RNO-3214847",
"R-RNO-6804760"
] | [
"REACTOME:R-HSA-3214847",
"REACTOME:R-HSA-6804760",
"REACTOME:R-MMU-3214847",
"REACTOME:R-MMU-6804760",
"REACTOME:R-RNO-3214847",
"REACTOME:R-RNO-6804760"
] | 6 | [
"1pxe",
"2cs8",
"2jx1",
"2jyd",
"2mf8"
] | 5 | [
"PUB00014077",
"PUB00030020",
"PUB00035804",
"PUB00035805",
"PUB00035806",
"PUB00035807",
"PUB00035812",
"PUB00048136",
"PUB00084246",
"PUB00084247",
"PUB00084248"
] | [
"12665246",
"14744132",
"17210253",
"15963892",
"15718139",
"10529348",
"11179890",
"18073212",
"24097990",
"25098749",
"26158299"
] | [
"Zinc fingers--folds for many occasions.",
"Solution structure of a CCHHC domain of neural zinc finger factor-1 and its implications for DNA binding.",
"Sticky fingers: zinc-fingers as protein-recognition motifs.",
"Multiple modes of RNA recognition by zinc finger proteins.",
"Zinc finger proteins: getting ... | [
2002,
2004,
2007,
2005,
2005,
1999,
2001,
2008,
2013,
2014,
2015
] | 11 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
13179
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
89,
52,
70,
23,
35
] | 6 | true | Repeat | Zinc finger, C2H2C-type | Zinc finger, C2H2C-type | Znf_C2H2C | 8 |
IPR002516 | 2,516 | Glycosyl transferase, family 11 | Glyco_trans_11 | Family | 6,079 | false | false | Glycosyltransferase family 11 comprises enzymes with only one known activity; galactoside 2-L-fucosyltransferase ( ). The biosynthesis of disaccharides, oligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These enzymes catalyse the transfer of sugar moieties from acti... | [
"GO:0008107",
"GO:0005975",
"GO:0016020"
] | [
"galactoside 2-alpha-L-fucosyltransferase activity",
"carbohydrate metabolic process",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PANTHER"
] | [
"PF01531",
"PTHR11927"
] | [
"Glyco_transf_11",
""
] | [
5973,
5327
] | 2 | [
"CAZY",
"EC",
"EC",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"GT11",
"2.4.1.344",
"2.4.1.69",
"GenProp1304",
"GenProp1518",
"PWY-7831",
"PWY-7832",
"PWY-7833",
"PWY-7839",
"PWY-8459",
"R-BTA-9033807",
"R-BTA-9840309",
"R-HSA-9033807",
"R-HSA-9037629",
"R-HSA-9840309",
"R-MMU-9033807",
"R-MMU-9037629",
"R-MMU-9840309",
"R-RNO-9033807",
"R... | [
"CAZY:GT11",
"EC:2.4.1.344",
"EC:2.4.1.69",
"GP:GenProp1304",
"GP:GenProp1518",
"METACYC:PWY-7831",
"METACYC:PWY-7832",
"METACYC:PWY-7833",
"METACYC:PWY-7839",
"METACYC:PWY-8459",
"REACTOME:R-BTA-9033807",
"REACTOME:R-BTA-9840309",
"REACTOME:R-HSA-9033807",
"REACTOME:R-HSA-9037629",
"REA... | 24 | [] | 0 | [
"PUB00009409"
] | [
"9334165"
] | [
"A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities."
] | [
1997
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"Viruses",
"metagenomes"
] | [
2340,
3421,
17,
52,
249
] | 5 | [
"Caenorhabditis elegans",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
23,
87,
13,
11
] | 4 | true | Family | Glycosyl transferase, family 11 | Glycosyl transferase, family 11 | Glyco_trans_11 | 4 |
IPR002517 | 2,517 | Tospovirus nucleocapsid protein | Tospo_nucleocap | Family | 2,077 | false | false | The tospovirus genome consists of three linear ssRNA segments, denoted L, M and S complexed with the nucleocapsid protein. The S RNA encodes the nucleocapsid protein and another non-structural protein [ ]. | [
"GO:0019013"
] | [
"viral nucleocapsid"
] | [
"cellular_component"
] | 1 | [
"PFAM",
"PIRSF"
] | [
"PF01533",
"PIRSF003948"
] | [
"Tospo_nucleocap",
"N_TospoV"
] | [
2077,
1584
] | 2 | [] | [] | [] | 0 | [
"5ip1",
"5ip2",
"5ip3",
"5y6j"
] | 4 | [
"PUB00003152"
] | [
"8429298"
] | [
"Classification of tospoviruses based on phylogeny of nucleoprotein gene sequences."
] | [
1993
] | 1 | [] | [] | 0 | 0 | null | [
"Viruses"
] | [
2077
] | 1 | [] | [] | 0 | true | Family | Tospovirus nucleocapsid protein | Tospovirus nucleocapsid protein | Tospo_nucleocap | 5 |
IPR002518 | 2,518 | Hepatitis C virus, Non-structural protein NS2 | HCV_NS2 | Domain | 15,529 | false | false | The viral genome is translated into a single polyprotein of about 3000 amino acids. Generation of the mature non-structural proteins relies on the activity of viral proteases. Non-structural protein 2 (NS2) is an zinc-dependent autocatalytic endopeptidase which cleaves at the NS2/NS3 junction [ , ]. The action of NS3 p... | [
"GO:0004197"
] | [
"cysteine-type endopeptidase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE"
] | [
"PF01538",
"PS51693"
] | [
"HCV_NS2",
"HCV_NS2_PRO"
] | [
14492,
15452
] | 2 | [
"EC",
"EC",
"EC",
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME"
] | [
"2.7.7.48",
"3.4.21.98",
"3.4.22.-",
"3.6.1.15",
"3.6.4.13",
"PWY-6545",
"PWY-7184",
"PWY-7185",
"PWY-7198",
"PWY-7210",
"R-HSA-5621480",
"R-HSA-8854214"
] | [
"EC:2.7.7.48",
"EC:3.4.21.98",
"EC:3.4.22.-",
"EC:3.6.1.15",
"EC:3.6.4.13",
"METACYC:PWY-6545",
"METACYC:PWY-7184",
"METACYC:PWY-7185",
"METACYC:PWY-7198",
"METACYC:PWY-7210",
"REACTOME:R-HSA-5621480",
"REACTOME:R-HSA-8854214"
] | 12 | [
"2hd0",
"2kwt",
"2kwz",
"2mkb"
] | 4 | [
"PUB00000745",
"PUB00003531",
"PUB00011704",
"PUB00020025",
"PUB00030423",
"PUB00041366",
"PUB00076953"
] | [
"9224925",
"9261354",
"11517925",
"9891971",
"14725770",
"16862121",
"7044372"
] | [
"The nonstructural proteins of the hepatitis C virus: structure and functions.",
"In vitro study of the NS2-3 protease of hepatitis C virus.",
"Evolutionary lines of cysteine peptidases.",
"Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine... | [
1997,
1997,
2001,
1998,
2004,
2006,
1982
] | 7 | [] | [] | 0 | 0 | null | [
"Actinomycetes",
"Riboviria",
"Sinocyclocheilus",
"bird metagenome"
] | [
4,
15522,
2,
1
] | 4 | [] | [] | 0 | true | Domain | Hepatitis C virus, Non-structural protein NS2 | Hepatitis C virus, Non-structural protein NS2 | HCV_NS2 | 4 |
IPR002519 | 2,519 | Hepatitis C virus, Envelope glycoprotein E1 | HCV_Env | Domain | 80,166 | false | false | Poliovirus infection leads to drastic alterations in membrane permeability late during infection. Proteins 2B and 2BC enhance membrane permeability [ , ]. | [
"GO:0019031"
] | [
"viral envelope"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF01539"
] | [
"HCV_env"
] | [
80166
] | 1 | [
"EC",
"EC",
"EC",
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME"
] | [
"2.7.7.48",
"3.4.21.98",
"3.4.22.-",
"3.6.1.15",
"3.6.4.13",
"PWY-6545",
"PWY-7184",
"PWY-7185",
"PWY-7198",
"PWY-7210",
"R-HSA-5621480",
"R-HSA-8854214"
] | [
"EC:2.7.7.48",
"EC:3.4.21.98",
"EC:3.4.22.-",
"EC:3.6.1.15",
"EC:3.6.4.13",
"METACYC:PWY-6545",
"METACYC:PWY-7184",
"METACYC:PWY-7185",
"METACYC:PWY-7198",
"METACYC:PWY-7210",
"REACTOME:R-HSA-5621480",
"REACTOME:R-HSA-8854214"
] | 12 | [
"1emz",
"2knu",
"4uoi",
"7t6x",
"8fsj",
"8rjj",
"8rk0"
] | 7 | [
"PUB00001304",
"PUB00002971"
] | [
"9218794",
"8798506"
] | [
"Coxsackievirus protein 2B modifies endoplasmic reticulum membrane and plasma membrane permeability and facilitates virus release.",
"Membrane permeabilization by poliovirus proteins 2B and 2BC."
] | [
1997,
1996
] | 2 | [] | [] | 0 | 0 | null | [
"Riboviria"
] | [
80166
] | 1 | [] | [] | 0 | true | Domain | Hepatitis C virus, Envelope glycoprotein E1 | Hepatitis C virus, Envelope glycoprotein E1 | HCV_Env | 5 |
IPR002520 | 2,520 | Adhesin lipoprotein | Lipoprotein_7 | Family | 29 | false | false | This family includes the p50 and variable adherence-associated antigen (Vaa) adhesins from Metamycoplasma hominis and some uncharacterised proteins from bacteria and archaea. M. hominis is a mycoplasma associated with human urogenital diseases, pneumonia, and septic arthritis [ ]. An adhesin is a cell surface molecule ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01540"
] | [
"Lipoprotein_7"
] | [
29
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00002031",
"PUB00002033"
] | [
"8698503",
"8926064"
] | [
"Molecular basis of size and antigenic variation of a Mycoplasma hominis adhesin encoded by divergent vaa genes.",
"Repetitive elements of the Mycoplasma hominis adhesin p50 can be differentiated by monoclonal antibodies."
] | [
1996,
1996
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
29
] | 1 | [] | [] | 0 | true | Family | Adhesin lipoprotein | Adhesin lipoprotein | Lipoprotein_7 | 2 |
IPR002522 | 2,522 | Hepatitis C virus, Core protein, N-terminal | HCV_core_N | Domain | 28,944 | false | false | Although Hepatitis A virus, Hepatitis B virus, and Hepatitis C virus have similar names, because they all cause liver inflammation, these are distinctly different viruses both genetically and clinically. The Hepatitis C virus (HCV) is a small (50-80 nm in diameter), enveloped, single-stranded, positive sense RNA virus.... | [
"GO:0005198",
"GO:0019028"
] | [
"structural molecule activity",
"viral capsid"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF01543"
] | [
"HCV_capsid"
] | [
28944
] | 1 | [
"EC",
"EC",
"EC",
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME"
] | [
"2.7.7.48",
"3.4.21.98",
"3.4.22.-",
"3.6.1.15",
"3.6.4.13",
"PWY-6545",
"PWY-7184",
"PWY-7185",
"PWY-7198",
"PWY-7210",
"R-HSA-5621480",
"R-HSA-8854214"
] | [
"EC:2.7.7.48",
"EC:3.4.21.98",
"EC:3.4.22.-",
"EC:3.6.1.15",
"EC:3.6.4.13",
"METACYC:PWY-6545",
"METACYC:PWY-7184",
"METACYC:PWY-7185",
"METACYC:PWY-7198",
"METACYC:PWY-7210",
"REACTOME:R-HSA-5621480",
"REACTOME:R-HSA-8854214"
] | 12 | [
"1cwx",
"1n64",
"1xcq",
"1xct",
"1xf5"
] | 5 | [
"PUB00020019",
"PUB00053353",
"PUB00053354",
"PUB00053355",
"PUB00099826"
] | [
"12145199",
"9621068",
"16528035",
"10900028",
"25443344"
] | [
"Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets.",
"The native form and maturation process of hepatitis C virus core protein.",
"Core protein cleavage by signal peptide peptidase is required for hepatitis C virus-like particle assembly.",
"Sequence motifs re... | [
2002,
1998,
2006,
2000,
2014
] | 5 | [] | [] | 0 | 0 | null | [
"Hepacivirus"
] | [
28944
] | 1 | [] | [] | 0 | true | Domain | Hepatitis C virus, Core protein, N-terminal | Hepatitis C virus, Core protein, N-terminal | HCV_core_N | 7 |
IPR002523 | 2,523 | Mg2+ transporter protein, CorA-like/Zinc transport protein ZntB | MgTranspt_CorA/ZnTranspt_ZntB | Family | 58,902 | false | false | This entry includes prokaryotic magnesium transport protein CorA and its related protein, zinc transport protein ZntB [ ]. This entry also includes eukaryotic magnesium transporters, such as mitochondrial inner membrane magnesium transporter Mrs2 and magnesium transporter Alr1 and Alr2. These proteins are characterised... | [
"GO:0046873",
"GO:0030001",
"GO:0055085",
"GO:0016020"
] | [
"metal ion transmembrane transporter activity",
"metal ion transport",
"transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PFAM"
] | [
"PF01544"
] | [
"CorA"
] | [
58902
] | 1 | [] | [] | [] | 0 | [
"2bbh",
"2bbj",
"2hn1",
"2hn2",
"2iub",
"3ck6",
"3jcf",
"3jcg",
"3jch",
"3nvo",
"3nwi",
"4cy4",
"4eeb",
"4eed",
"4egw",
"4ev6",
"4i0u",
"5jrw",
"5jtg",
"5n77",
"5n78",
"5n9y",
"7nh9",
"8slb",
"8tmb",
"8tmc",
"8tmd",
"8tme",
"8tmf",
"8tmg",
"8tmh",
"8tmi"... | 42 | [
"PUB00041779",
"PUB00054950",
"PUB00065208",
"PUB00072756",
"PUB00072757",
"PUB00072774",
"PUB00072775"
] | [
"16857941",
"12142406",
"23425532",
"12206392",
"17619822",
"9430719",
"12628916"
] | [
"Crystal structure of a divalent metal ion transporter CorA at 2.9 angstrom resolution.",
"ZntB is a novel Zn2+ transporter in Salmonella enterica serovar Typhimurium.",
"Exploring the structure and function of Thermotoga maritima CorA reveals the mechanism of gating and ion selectivity in Co2+/Mg2+ transport."... | [
2006,
2002,
2013,
2002,
2007,
1998,
2003
] | 7 | [] | [
"IPR004488",
"IPR023714",
"IPR044089",
"IPR047199"
] | 0 | 4 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
635,
39344,
18563,
11,
349
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
21,
2,
10,
9,
3,
2,
14
] | 7 | true | Family | Mg2+ transporter protein, CorA-like/Zinc transport protein ZntB | Mg2+ transporter protein, CorA-like/Zinc transport protein ZntB | MgTranspt_CorA/ZnTranspt_ZntB | 4 |
IPR002524 | 2,524 | Cation efflux | Cation_efflux | Family | 89,668 | false | false | This family has six predicted transmembrane domains. Members of the family are variable in length because of variably sized inserts, often containing low-complexity sequence. Cation Diffusion Facilitator (CDF) transporter proteins, including SLC30A, which is involved in zinc transport, and FieF, which is associated wit... | [
"GO:0008324",
"GO:0006812",
"GO:0055085",
"GO:0016020"
] | [
"monoatomic cation transmembrane transporter activity",
"monoatomic cation transport",
"transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"NCBIFAM"
] | [
"TIGR01297"
] | [
"CDF"
] | [
89668
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-425410",
"R-CEL-435368",
"R-DDI-264876",
"R-DDI-425410",
"R-DDI-435368",
"R-DRE-264876",
"R-DRE-435368",
"R-GGA-264876",
"R-GGA-435368",
"R-HSA-264876",
"R-HSA-425410",
"R-HSA-435368",
"R-MMU-264876",
"R-MMU-425410",
"R-MMU-435368",
"R-RNO-264876",
"R-RNO-435368",
"R-SCE-264... | [
"REACTOME:R-CEL-425410",
"REACTOME:R-CEL-435368",
"REACTOME:R-DDI-264876",
"REACTOME:R-DDI-425410",
"REACTOME:R-DDI-435368",
"REACTOME:R-DRE-264876",
"REACTOME:R-DRE-435368",
"REACTOME:R-GGA-264876",
"REACTOME:R-GGA-435368",
"REACTOME:R-HSA-264876",
"REACTOME:R-HSA-425410",
"REACTOME:R-HSA-435... | 25 | [
"2qfi",
"3h90",
"3j1z",
"5vrf",
"6xpd",
"6xpe",
"6xpf",
"7kzx",
"7kzz",
"7y5g",
"7y5h",
"8f6e",
"8f6f",
"8f6h",
"8f6i",
"8f6j",
"8f6k",
"8j2g",
"8j7t",
"8j7u",
"8j7v",
"8j7w",
"8j7x",
"8j7y",
"8j80",
"8xm6",
"8xma",
"8xmf",
"8xmj",
"8xn1",
"8zb0",
"8zsb"... | 41 | [
"PUB00000764",
"PUB00002316",
"PUB00009562"
] | [
"8829543",
"9696746",
"1508175"
] | [
"Cloning and sequence analysis of czc genes in Alcaligenes sp. strain CT14.",
"Molecular characterization of a chromosomal determinant conferring resistance to zinc and cobalt ions in Staphylococcus aureus.",
"COT1, a gene involved in cobalt accumulation in Saccharomyces cerevisiae."
] | [
1996,
1998,
1992
] | 3 | [] | [
"IPR023500",
"IPR040177",
"IPR045316",
"IPR050291"
] | 0 | 4 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1596,
54796,
32571,
5,
700
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
61,
13,
19,
14,
2,
28,
30,
6,
14,
31,
5,
3,
48
] | 13 | true | Family | Cation efflux | Cation efflux | Cation_efflux | 2 |
IPR002525 | 2,525 | Transposase IS110-like, N-terminal | Transp_IS110-like_N | Domain | 39,810 | false | false | Transposase proteins are necessary for efficient DNA transposition. This entry represents the N-terminal region of the pilin gene inverting protein (PIVML) and members of the IS111A/IS1328/IS1533 family of transposases [ , , ]. | [
"GO:0003677",
"GO:0004803",
"GO:0006313"
] | [
"DNA binding",
"transposase activity",
"DNA transposition"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM"
] | [
"PF01548"
] | [
"DEDD_Tnp_IS110"
] | [
39810
] | 1 | [] | [] | [] | 0 | [
"8wt6",
"8wt7",
"8wt8",
"8wt9"
] | 4 | [
"PUB00034634",
"PUB00034635",
"PUB00034638"
] | [
"10620670",
"10220167",
"10217489"
] | [
"Local hopping of IS3 elements into the A+T-rich part of the high-pathogenicity island in Yersinia enterocolitica 1B, O:8.",
"New insertion sequences and a novel repeated sequence in the genome of Mycobacterium tuberculosis H37Rv.",
"Characterization of IS2112, a new insertion sequence from Rhodococcus, and its... | [
2000,
1999,
1999
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"plasmids",
"unclassified sequences"
] | [
552,
38395,
106,
18,
3,
736
] | 6 | [] | [] | 0 | true | Domain | Transposase IS110-like, N-terminal | Transposase IS110-like, N-terminal | Transp_IS110-like_N | 2 |
IPR002527 | 2,527 | Picornavirus 2B protein | Pico_P2B | Domain | 8,147 | false | false | Poliovirus infection leads to drastic alterations in membrane permeability late during infection. Proteins 2B and 2BC enhance membrane permeability [ , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01552"
] | [
"Pico_P2B"
] | [
8147
] | 1 | [
"EC",
"EC",
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.7.7.48",
"3.4.22.28",
"3.4.22.29",
"3.6.1.15",
"PWY-6545",
"PWY-7184",
"PWY-7185",
"PWY-7198",
"PWY-7210"
] | [
"EC:2.7.7.48",
"EC:3.4.22.28",
"EC:3.4.22.29",
"EC:3.6.1.15",
"METACYC:PWY-6545",
"METACYC:PWY-7184",
"METACYC:PWY-7185",
"METACYC:PWY-7198",
"METACYC:PWY-7210"
] | 9 | [] | 0 | [
"PUB00001304",
"PUB00002971"
] | [
"9218794",
"8798506"
] | [
"Coxsackievirus protein 2B modifies endoplasmic reticulum membrane and plasma membrane permeability and facilitates virus release.",
"Membrane permeabilization by poliovirus proteins 2B and 2BC."
] | [
1997,
1996
] | 2 | [] | [] | 0 | 0 | null | [
"Riboviria",
"Trichinella"
] | [
8143,
4
] | 2 | [] | [] | 0 | true | Domain | Picornavirus 2B protein | Picornavirus 2B protein | Pico_P2B | 9 |
IPR002528 | 2,528 | Multi antimicrobial extrusion protein | MATE_fam | Family | 138,662 | false | false | In general, proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR) [ , ]. These proteins mediate resistance to a wide range of cationic dyes, fluroquinolones, aminoglycosides and other structurally diverse antibodies and drug... | [
"GO:0015297",
"GO:0042910",
"GO:0055085",
"GO:0016020"
] | [
"antiporter activity",
"xenobiotic transmembrane transporter activity",
"transmembrane transport",
"membrane"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"PFAM",
"NCBIFAM"
] | [
"PF01554",
"TIGR00797"
] | [
"MatE",
"matE"
] | [
138653,
113680
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-425366",
"R-HSA-425366",
"R-MMU-425366",
"R-RNO-425366",
"R-SCE-425366",
"R-SPO-425366",
"R-XTR-425366"
] | [
"REACTOME:R-DRE-425366",
"REACTOME:R-HSA-425366",
"REACTOME:R-MMU-425366",
"REACTOME:R-RNO-425366",
"REACTOME:R-SCE-425366",
"REACTOME:R-SPO-425366",
"REACTOME:R-XTR-425366"
] | 7 | [
"3mkt",
"3mku",
"3vvn",
"3vvo",
"3vvp",
"3vvr",
"3vvs",
"3w4t",
"3wbn",
"4huk",
"4hul",
"4hum",
"4hun",
"4lz6",
"4lz9",
"4mlb",
"4z3n",
"4z3p",
"5c6n",
"5c6o",
"5c6p",
"5xjj",
"5y50",
"5yck",
"6fhz",
"6fv6",
"6fv7",
"6fv8",
"6gwh",
"6hfb",
"6idp",
"6idr"... | 42 | [
"PUB00075397",
"PUB00096596"
] | [
"12603313",
"11104814"
] | [
"The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily.",
"Molecular properties of bacterial multidrug transporters."
] | [
2003,
2000
] | 2 | [] | [
"IPR044644",
"IPR045069",
"IPR048279"
] | 0 | 3 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
2850,
86702,
48040,
5,
1065
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)... | [
268,
14,
3,
11,
5,
3,
190,
6,
2,
3,
282
] | 11 | true | Family | Multi antimicrobial extrusion protein | Multi antimicrobial extrusion protein | MATE_fam | 7 |
IPR002530 | 2,530 | Zein seed storage protein | Zein | Family | 586 | false | false | Alpha-prolamins are the major seed storage proteins of species of the grass tribe Andropogonea. They are unusually rich in glutamine, proline, alanine, and leucine residues and their sequences show a series of tandem repeats presumed to be the result of multiple intragenic duplication [ ]. In Zea mays (Maize), the 22kD... | [
"GO:0045735"
] | [
"nutrient reservoir activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF01559"
] | [
"Zein"
] | [
586
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00004987",
"PUB00009563"
] | [
"8451243",
"11691845"
] | [
"Studies of the zein-like alpha-prolamins based on an analysis of amino acid sequences: implications for their evolution and three-dimensional structure.",
"Sequence, regulation, and evolution of the maize 22-kD alpha zein gene family."
] | [
1993,
2001
] | 2 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Eukaryota"
] | [
2,
584
] | 2 | [
"Zea mays"
] | [
283
] | 1 | true | Family | Zein seed storage protein | Zein seed storage protein | Zein | 6 |
IPR002531 | 2,531 | Hepatitis C virus, Non-structural protein E2/NS1 | HCV_NS1 | Domain | 84,034 | false | false | The hypervariable region of the E2/NS1 region of Hepatitis C virus varies greatly between viral isolates. E2 is thought to encode a structurally unconstrained envelope protein [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01560"
] | [
"HCV_NS1"
] | [
84034
] | 1 | [
"EC",
"EC",
"EC",
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME"
] | [
"2.7.7.48",
"3.4.21.98",
"3.4.22.-",
"3.6.1.15",
"3.6.4.13",
"PWY-6545",
"PWY-7184",
"PWY-7185",
"PWY-7198",
"PWY-7210",
"R-HSA-5621480",
"R-HSA-8854214"
] | [
"EC:2.7.7.48",
"EC:3.4.21.98",
"EC:3.4.22.-",
"EC:3.6.1.15",
"EC:3.6.4.13",
"METACYC:PWY-6545",
"METACYC:PWY-7184",
"METACYC:PWY-7185",
"METACYC:PWY-7198",
"METACYC:PWY-7210",
"REACTOME:R-HSA-5621480",
"REACTOME:R-HSA-8854214"
] | 12 | [
"2kzq",
"4mwf",
"4q0x",
"4web",
"5fgb",
"5fgc",
"6bkb",
"6bkc",
"6bkd",
"6meh",
"6mei",
"6mej",
"6mek",
"6urh",
"6uyd",
"6uyf",
"6uyg",
"6uym",
"6wo3",
"6wo4",
"6wo5",
"6woq",
"7jtf",
"7jtg",
"7mww",
"7mwx",
"7rfb",
"7rfc",
"7t6x",
"8dk6",
"8fsj",
"8rjj"... | 43 | [
"PUB00001990"
] | [
"9425941"
] | [
"Comparison of the rate of sequence variation in the hypervariable region of E2/NS1 region of hepatitis C virus in normal and hypogammaglobulinemic patients."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Hepacivirus"
] | [
84034
] | 1 | [] | [] | 0 | true | Domain | Hepatitis C virus, Non-structural protein E2/NS1 | Hepatitis C virus, Non-structural protein E2/NS1 | HCV_NS1 | 2 |
IPR002532 | 2,532 | Hantavirus glycoprotein Gc, N-terminal domain | Hanta_Gc_N | Domain | 2,765 | false | false | This entry represents the polyprotein region which forms the N-terminal region of Gc glycoprotein. It has been shown that the N-terminal region of glycoprotein Gc has the conserved CNP motif, suggested to be an integrin-binding motif [ ]. Gc protein has a typical class II fusion protein fold consisting of a central β-s... | [
"GO:0044423"
] | [
"virion component"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF01561"
] | [
"Hanta_Gc_N"
] | [
2765
] | 1 | [] | [] | [] | 0 | [
"5j81",
"5j9h",
"5ljx",
"5ljy",
"5ljz",
"5lk0",
"5lk1",
"5lk2",
"5lk3",
"6y5f",
"6y5w",
"6y62",
"6y68",
"6y6q",
"6z06",
"6zjm",
"7a59",
"7a5a",
"7b09",
"7b0a",
"7fgf",
"7l7r",
"7qqb",
"8jkd",
"8jlw",
"8jlx",
"9b8j",
"9p3i",
"9p3l",
"9p3m",
"9p3x",
"9p3y"... | 32 | [
"PUB00004342",
"PUB00094390",
"PUB00094420",
"PUB00100090",
"PUB00100091"
] | [
"3114716",
"16310165",
"27783711",
"32937107",
"11886265"
] | [
"Nucleotide sequence of the M segment of the genomic RNA of Hantaan virus 76-118.",
"Cellular entry of Hantaan virus A9 strain: specific interactions with beta3 integrins and a novel 70kDa protein.",
"Mechanistic Insight into Bunyavirus-Induced Membrane Fusion from Structure-Function Analyses of the Hantavirus ... | [
1987,
2006,
2016,
2020,
2002
] | 5 | [] | [] | 0 | 0 | null | [
"Ixodes ricinus",
"Riboviria"
] | [
1,
2764
] | 2 | [] | [] | 0 | true | Domain | Hantavirus glycoprotein Gc, N-terminal domain | Hantavirus glycoprotein Gc, N-terminal domain | Hanta_Gc_N | 7 |
IPR002533 | 2,533 | Alphavirus E3 spike glycoprotein | Alpha_E3_glycop | Domain | 2,333 | false | false | Alphaviruses are enveloped RNA viruses that use arthropods such as mosquitoes for transmission to their vertebrate hosts, and include Semliki Forest and Sindbis viruses [ ]. Alphaviruses consist of three structural proteins: the core nucleocapsid protein C, and the envelope proteins P62 and E1 ( ) that associate as a h... | [
"GO:0004252",
"GO:0019028",
"GO:0055036"
] | [
"serine-type endopeptidase activity",
"viral capsid",
"virion membrane"
] | [
"molecular_function",
"cellular_component",
"cellular_component"
] | 3 | [
"PFAM"
] | [
"PF01563"
] | [
"Alpha_E3_glycop"
] | [
2333
] | 1 | [
"EC"
] | [
"3.4.21.90"
] | [
"EC:3.4.21.90"
] | 1 | [
"3j0g",
"3n40",
"3n41",
"3n42",
"3n43",
"3n44",
"5vu2",
"6imm",
"6jo8",
"6nk7",
"6w09",
"7ffe",
"7fff",
"7ffl",
"7ffn",
"7ffo",
"7ffq",
"8eeu",
"8eev",
"8ua4",
"8ua8",
"8ua9",
"8yvy",
"8yvz",
"8yw0",
"8yw1",
"8yw2",
"9bbn",
"9bhh",
"9iw2"
] | 30 | [
"PUB00003542",
"PUB00006300",
"PUB00015616",
"PUB00015617"
] | [
"9445057",
"8107141",
"11301009",
"15378043"
] | [
"Structural localization of the E3 glycoprotein in attenuated Sindbis virus mutants.",
"The organization of the spike complex of Semliki Forest virus.",
"The Fusion glycoprotein shell of Semliki Forest virus: an icosahedral assembly primed for fusogenic activation at endosomal pH.",
"Transmission cycles, host... | [
1998,
1994,
2001,
2004
] | 4 | [] | [] | 0 | 0 | null | [
"Alphavirus"
] | [
2333
] | 1 | [] | [] | 0 | true | Domain | Alphavirus E3 spike glycoprotein | Alphavirus E3 spike glycoprotein | Alpha_E3_glycop | 2 |
IPR002534 | 2,534 | Hantavirus glycoprotein Gn, head | Hanta_Gn-H | Domain | 954 | false | false | This entry represents the Gn glycoprotein in which, the N-terminal two-thirds has been denoted as 'head' (Gn-H) interacts with Gc ectodomain. Release of Gn-H at acid pH induces a further conformational change of the Gc domain II tip which exposes non-polar side chains for insertion into the endosomal membrane [ , ]. Th... | [
"GO:0044423"
] | [
"virion component"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF01567"
] | [
"Hanta_Gn-H"
] | [
954
] | 1 | [] | [] | [] | 0 | [
"5fxu",
"5fyn",
"5opg",
"6y5f",
"6y5w",
"6y62",
"6y6p",
"6zjm",
"7b09",
"7b0a",
"7nks",
"7nrh",
"7o9s",
"7qqb",
"8ahn",
"8dbz",
"8zgu",
"9p3i",
"9p3l",
"9p3m",
"9p3x",
"9p3y"
] | 22 | [
"PUB00004342",
"PUB00094420",
"PUB00100090",
"PUB00100091"
] | [
"3114716",
"27783711",
"32937107",
"11886265"
] | [
"Nucleotide sequence of the M segment of the genomic RNA of Hantaan virus 76-118.",
"Mechanistic Insight into Bunyavirus-Induced Membrane Fusion from Structure-Function Analyses of the Hantavirus Envelope Glycoprotein Gc.",
"The Hantavirus Surface Glycoprotein Lattice and Its Fusion Control Mechanism.",
"Hant... | [
1987,
2016,
2020,
2002
] | 4 | [] | [] | 0 | 0 | null | [
"Hantaviridae"
] | [
954
] | 1 | [] | [] | 0 | true | Domain | Hantavirus glycoprotein Gn, head | Hantavirus glycoprotein Gn, head | Hanta_Gn-H | 3 |
IPR002538 | 2,538 | Bromovirus movement protein | Bromo_MP | Family | 512 | false | false | Members of this family are found in the bromoviridae, assembling into long tubular structures at the surface of the infected protoplast. These proteins aid the infection of the virus [ , ]. | [
"GO:0046740",
"GO:0044156"
] | [
"transport of virus in host, cell to cell",
"host cell junction"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF01573"
] | [
"Bromo_MP"
] | [
512
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00003171",
"PUB00006401"
] | [
"9267012",
"9514964"
] | [
"Tubule-forming capacity of the movement proteins of alfalfa mosaic virus and brome mosaic virus.",
"Characterization of the brome mosaic virus movement protein expressed in E. coli."
] | [
1997,
1998
] | 2 | [] | [] | 0 | 0 | null | [
"Bromoviridae"
] | [
512
] | 1 | [] | [] | 0 | true | Family | Bromovirus movement protein | Bromovirus movement protein | Bromo_MP | 3 |
IPR002539 | 2,539 | MaoC-like dehydratase domain | MaoC-like_dom | Domain | 69,284 | false | false | The maoC gene is part of an operon with maoA which is involved in the synthesis of monoamine oxidase [ ]. The MaoC protein shares similarity with a region found in a wide variety of enzymes, such as peroxisomal hydratase-dehydrogenase-epimerase and fatty acid synthase beta subunit. A deletion mutant of the C-terminal 2... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01575"
] | [
"MaoC_dehydratas"
] | [
69284
] | 1 | [
"EC",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"4.2.1",
"GenProp1436",
"R-DDI-193368",
"R-DDI-2046106",
"R-DDI-389887",
"R-DDI-390247",
"R-DDI-9033241",
"R-DME-193368",
"R-DME-2046106",
"R-DME-389887",
"R-DME-390247",
"R-DME-9033241",
"R-HSA-193368",
"R-HSA-2046106",
"R-HSA-389887",
"R-HSA-390247",
"R-HSA-75105",
"R-HSA-9033241... | [
"EC:4.2.1",
"GP:GenProp1436",
"REACTOME:R-DDI-193368",
"REACTOME:R-DDI-2046106",
"REACTOME:R-DDI-389887",
"REACTOME:R-DDI-390247",
"REACTOME:R-DDI-9033241",
"REACTOME:R-DME-193368",
"REACTOME:R-DME-2046106",
"REACTOME:R-DME-389887",
"REACTOME:R-DME-390247",
"REACTOME:R-DME-9033241",
"REACTOM... | 29 | [
"1iq6",
"1pn2",
"1pn4",
"1q6w",
"1s9c",
"2b3m",
"2c2i",
"2cdh",
"2uv8",
"2vkz",
"3exz",
"3hmj",
"3ir3",
"3k67",
"3kh8",
"3khp",
"3oml",
"3wew",
"4ffu",
"4oob",
"4rlj",
"4rlt",
"4rlu",
"4rlw",
"4rv2",
"4v12",
"4v58",
"4v59",
"4v8l",
"4v8v",
"4v8w",
"5cpg"... | 79 | [
"PUB00002170",
"PUB00006156",
"PUB00045020"
] | [
"1556068",
"1551874",
"9457873"
] | [
"A monoamine-regulated Klebsiella aerogenes operon containing the monoamine oxidase structural gene (maoA) and the maoC gene.",
"Peroxisomal multifunctional beta-oxidation protein of Saccharomyces cerevisiae. Molecular analysis of the fox2 gene and gene product.",
"Expression and characterization of (R)-specifi... | [
1992,
1992,
1998
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Haloarcula tailed virus 2",
"unclassified sequences"
] | [
1673,
55293,
11415,
1,
902
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
9,
1,
1,
3,
1,
18,
4,
3,
5,
8,
2,
1,
18
] | 13 | true | Domain | MaoC-like dehydratase domain | MaoC-like dehydratase domain | MaoC-like_dom | 1 |
IPR002540 | 2,540 | Peptidase S30, polyprotein P1, potyvirus | Pept_S30_P1_potyvir | Domain | 5,135 | false | false | Proteolytic enzymes that exploit serine in their catalytic activity are ubiquitous, being found in viruses, bacteria and eukaryotes [ ]. They include a wide range of peptidase activity, including exopeptidase, endopeptidase, oligopeptidase and omega-peptidase activity. Many families of serine protease have been identif... | [
"GO:0004197",
"GO:0006508"
] | [
"cysteine-type endopeptidase activity",
"proteolysis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PROFILE"
] | [
"PF01577",
"PS51871"
] | [
"Peptidase_S30",
"PV_P1_PRO"
] | [
4768,
4996
] | 2 | [
"EC",
"EC",
"METACYC"
] | [
"3.4.21.-",
"3.4.22.45",
"PWY-7884"
] | [
"EC:3.4.21.-",
"EC:3.4.22.45",
"METACYC:PWY-7884"
] | 3 | [] | 0 | [
"PUB00000522",
"PUB00003163",
"PUB00003576",
"PUB00005588",
"PUB00097802"
] | [
"8439290",
"7844540",
"7845208",
"1529535",
"32984814"
] | [
"Evolutionary families of peptidases.",
"Characterization of the P1 protein and coding region of the zucchini yellow mosaic virus.",
"Families of serine peptidases.",
"Mutational analysis of the tobacco etch potyviral 35-kDa proteinase: identification of essential residues and requirements for autoproteolysis... | [
1993,
1995,
1994,
1992,
2020
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Orthornavirae"
] | [
2,
5133
] | 2 | [] | [] | 0 | true | Domain | Peptidase S30, polyprotein P1, potyvirus | Peptidase S30, polyprotein P1, potyvirus | Pept_S30_P1_potyvir | 2 |
IPR002541 | 2,541 | Cytochrome c assembly protein | Cyt_c_assembly | Domain | 64,053 | false | false | This domain is found in various proteins involved in cytochrome c assembly from mitochondria, chloroplast and bacteria; including among others CycK from Rhizobium leguminosarum [ ], CcmC and CcmF from Escherichia coli [ ], CcsA from Chlamydomonas [ ], and orf240 from Triticum aestivum (wheat) mitochondria [ ]. CcmC int... | [
"GO:0020037",
"GO:0017004"
] | [
"heme binding",
"cytochrome complex assembly"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF01578"
] | [
"Cytochrom_C_asm"
] | [
64053
] | 1 | [] | [] | [] | 0 | [
"6zmq",
"7f02",
"7f03",
"7f04",
"7s9y",
"7s9z",
"7vfj",
"7vfp",
"8ce1",
"8ce5",
"8ce8",
"8cea"
] | 12 | [
"PUB00002274",
"PUB00002276",
"PUB00003769",
"PUB00070849",
"PUB00070851",
"PUB00070854"
] | [
"7635817",
"7665469",
"7529870",
"10339610",
"8617725",
"22066495"
] | [
"Escherichia coli genes required for cytochrome c maturation.",
"Characterization of the cycHJKL genes involved in cytochrome c biogenesis and symbiotic nitrogen fixation in Rhizobium leguminosarum.",
"A gene proposed to encode a transmembrane domain of an ABC transporter is expressed in wheat mitochondria.",
... | [
1995,
1995,
1995,
1999,
1996,
2011
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Escherichia phage vB_EcoM-613R3",
"Eukaryota",
"unclassified sequences"
] | [
340,
44047,
1,
18667,
998
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
18,
4,
11,
5
] | 4 | true | Domain | Cytochrome c assembly protein | Cytochrome c assembly protein | Cyt_c_assembly | 5 |
IPR002542 | 2,542 | T20D4.11-like domain | T20D4.11-like_dom | Domain | 1,210 | false | false | This domain is found in a group of uncharacterised proteins from nematodes, including (T20D4.11) and Excretory canal abnormal exc-13 from Caenorhabditis elegans. Members of this group have been reported to be negative regulators of growth and development in response to some stress and environmental conditions that are ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01579"
] | [
"DUF19"
] | [
1210
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155449"
] | [
"34471121"
] | [
"Histone deacetylase HDA-4-mediated epigenetic regulation in space-flown C. elegans."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1210
] | 1 | [
"Caenorhabditis elegans"
] | [
87
] | 1 | true | Domain | T20D4.11-like domain | T20D4.11-like domain | T20D4.11-like_dom | 3 |
IPR002543 | 2,543 | FtsK domain | FtsK_dom | Domain | 56,561 | false | false | The FtsK domain is a hydrophilic domain of about 200 residues, which is found in: Bacterial cell division protein ftsK (known as sporulation protein SpoIIIE in Bacillus subtilis). A set of conjugative plasmid- and conjugative transposon-encoded proteins, generally called Tra proteins. These proteins come from an extrem... | [
"GO:0000166",
"GO:0003677",
"GO:0005524"
] | [
"nucleotide binding",
"DNA binding",
"ATP binding"
] | [
"molecular_function",
"molecular_function",
"molecular_function"
] | 3 | [
"PFAM",
"PROFILE"
] | [
"PF01580",
"PS50901"
] | [
"FtsK_SpoIIIE",
"FTSK"
] | [
53733,
55404
] | 2 | [
"PROSITEDOC"
] | [
"PDOC50901"
] | [
"PROSITEDOC:PDOC50901"
] | 1 | [
"2ius",
"2iut",
"2iuu",
"4lya",
"4n1a",
"4nh0",
"5fv0",
"6j18",
"6j19",
"6jd4",
"6jd5",
"6o1w",
"6o1x",
"6o1y",
"6o1z",
"6t8b",
"6t8g",
"6t8o",
"7b9f",
"7b9s",
"7np7",
"7npr",
"7npt",
"7npu",
"7npv",
"9jv8"
] | 26 | [
"PUB00002282",
"PUB00018370",
"PUB00018371"
] | [
"7592387",
"11433368",
"11973144"
] | [
"A new Escherichia coli cell division gene, ftsK.",
"DNA transport in bacteria.",
"The ESAT-6/WXG100 superfamily -- and a new Gram-positive secretion system?"
] | [
1995,
2001,
2002
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
21,
55613,
81,
122,
724
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | FtsK domain | FtsK domain | FtsK_dom | 1 |
IPR002544 | 2,544 | FMRFamide-related peptide-like | FMRFamid-related_peptide-like | Family | 1,260 | false | false | null | [
"GO:0007218"
] | [
"neuropeptide signaling pathway"
] | [
"biological_process"
] | 1 | [
"PFAM"
] | [
"PF01581"
] | [
"FARP"
] | [
1260
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00006239",
"PUB00006244",
"PUB00006274"
] | [
"3067224",
"1968092",
"1549595"
] | [
"The action of FMRFamide (Phe-Met-Arg-Phe-NH2) and related peptides on mammals.",
"Cardioactive neuropeptide Phe-Met-Arg-Phe-NH2 (FMRFamide) and novel related peptides are encoded in multiple copies by a single gene in the snail Lymnaea stagnalis.",
"Isolation, structure, and activity of -Phe-Met-Arg-Phe-NH2 ne... | [
1988,
1990,
1992
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
9,
1251
] | 2 | [
"Caenorhabditis elegans",
"Drosophila melanogaster"
] | [
12,
1
] | 2 | true | Family | FMRFamide-related peptide-like | FMRFamide-related peptide-like | FMRFamid-related_peptide-like | 8 |
IPR002545 | 2,545 | CheW-like domain | CheW-lke_dom | Domain | 71,292 | false | false | The CheW-like domain is an around 150-residue domain that is found in proteins involved in the two-component signaling systems regulating bacterial chemotaxis. Two components systems are composed of a receptor kinase, which monitors the environmental conditions and its substrate, the response regulator, which acts as a... | [
"GO:0006935",
"GO:0007165"
] | [
"chemotaxis",
"signal transduction"
] | [
"biological_process",
"biological_process"
] | 2 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF01584",
"PS50851",
"SM00260"
] | [
"CheW",
"CHEW",
"CheW"
] | [
71173,
69034,
69221
] | 3 | [
"PROSITEDOC"
] | [
"PDOC50851"
] | [
"PROSITEDOC:PDOC50851"
] | 1 | [
"1b3q",
"1k0s",
"2ch4",
"2ho9",
"2qdl",
"3ja6",
"3ur1",
"4jpb",
"6s1k",
"8c5v"
] | 10 | [
"PUB00000966",
"PUB00018324",
"PUB00018325",
"PUB00018326"
] | [
"9989504",
"11553614",
"12511501",
"11799399"
] | [
"Structure of CheA, a signal-transducing histidine kinase.",
"Phosphorylation of the response regulator CheV is required for adaptation to attractants during Bacillus subtilis chemotaxis.",
"Different evolutionary constraints on chemotaxis proteins CheW and CheY revealed by heterologous expression studies and p... | [
1999,
2001,
2003,
2002
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacillus thuringiensis phage MZTP02",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1508,
1,
68822,
63,
898
] | 5 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Domain | CheW-like domain | CheW-like domain | CheW-lke_dom | 1 |
IPR002546 | 2,546 | Myogenic muscle-specific protein, N-terminal | MyoD_N | Domain | 4,011 | false | false | Members of the bHLH family of transcription factors share homology within a basic domain and an adjacent helix-loop-helix motif. Myogenic factor MyoD belongs to the bHLH family [ ]. This domain can be found at the N terminus of MyoD, which is muscle specific protein that control muscle development. This domain includes... | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF01586",
"SM00520"
] | [
"Basic",
"BASIC"
] | [
3990,
3992
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-525793",
"R-DME-525793",
"R-DRE-525793",
"R-GGA-525793",
"R-HSA-525793",
"R-HSA-9839394",
"R-MMU-525793",
"R-RNO-525793",
"R-SSC-525793"
] | [
"REACTOME:R-BTA-525793",
"REACTOME:R-DME-525793",
"REACTOME:R-DRE-525793",
"REACTOME:R-GGA-525793",
"REACTOME:R-HSA-525793",
"REACTOME:R-HSA-9839394",
"REACTOME:R-MMU-525793",
"REACTOME:R-RNO-525793",
"REACTOME:R-SSC-525793"
] | 9 | [] | 0 | [
"PUB00003705",
"PUB00004903",
"PUB00075517"
] | [
"9343420",
"8790335",
"17395511"
] | [
"The basic domain of myogenic basic helix-loop-helix (bHLH) proteins is the novel target for direct inhibition by another bHLH protein, Twist.",
"Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors.",
"Molecular cloning and characterization of the Myf5 gene i... | [
1997,
1996,
2007
] | 3 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
4011
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
2,
7,
6,
10
] | 5 | true | Domain | Myogenic muscle-specific protein, N-terminal | Myogenic muscle-specific protein, N-terminal | MyoD_N | 2 |
IPR002547 | 2,547 | tRNA-binding domain | tRNA-bd_dom | Domain | 65,614 | false | false | This domain is found in prokaryotic methionyl-tRNA synthetases, prokaryotic phenylalanyl tRNA synthetases, the yeast GU4 nucleic-binding protein (G4p1 or p42, ARC1) [ ], human tyrosyl-tRNA synthetase [ ], endothelial-monocyte activating polypeptide II and export-related chaperon CsaA [ ]. G4p1 binds specifically to tRN... | [
"GO:0000049"
] | [
"tRNA binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE"
] | [
"PF01588",
"PS50886"
] | [
"tRNA_bind",
"TRBD"
] | [
64360,
65518
] | 2 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"6.1.1",
"PDOC50886",
"R-DDI-9856649",
"R-HSA-2408522",
"R-HSA-379716",
"R-HSA-9856649",
"R-MMU-9856649"
] | [
"EC:6.1.1",
"PROSITEDOC:PDOC50886",
"REACTOME:R-DDI-9856649",
"REACTOME:R-HSA-2408522",
"REACTOME:R-HSA-379716",
"REACTOME:R-HSA-9856649",
"REACTOME:R-MMU-9856649"
] | 7 | [
"1b70",
"1b7y",
"1e7z",
"1eiy",
"1euj",
"1fl0",
"1gd7",
"1jjc",
"1mkh",
"1ntg",
"1pyb",
"1pys",
"1rqg",
"2akw",
"2aly",
"2amc",
"2cwp",
"2e8g",
"2iy5",
"2nzh",
"2nzo",
"2q2h",
"2q2i",
"2rhq",
"2rhs",
"3bu2",
"3ers",
"3g48",
"3hfz",
"3pco",
"3teh",
"4p71"... | 73 | [
"PUB00001293",
"PUB00002992",
"PUB00017744",
"PUB00160925"
] | [
"8895587",
"9162081",
"11157762",
"40274265"
] | [
"The yeast protein Arc1p binds to tRNA and functions as a cofactor for the methionyl- and glutamyl-tRNA synthetases.",
"Human tyrosyl-tRNA synthetase shares amino acid sequence homology with a putative cytokine.",
"The crystal structure of the ttCsaA protein: an export-related chaperone from Thermus thermophilu... | [
1996,
1997,
2001,
2025
] | 4 | [] | [
"IPR004495",
"IPR033714"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1246,
53781,
9643,
2,
942
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
14,
2,
7,
2,
3,
9,
5,
1,
8,
10,
1,
1,
41
] | 13 | true | Domain | tRNA-binding domain | tRNA-binding domain | tRNA-bd_dom | 2 |
IPR002548 | 2,548 | Alphavirus E1 glycoprotein | Alpha_E1_glycop | Domain | 5,077 | false | false | Alphaviruses are enveloped RNA viruses that use arthropods such as mosquitoes for transmission to their vertebrate hosts, and include Semliki Forest and Sindbis viruses [ ]. Alphaviruses consist of three structural proteins: the core nucleocapsid protein C, and the envelope proteins P62 and E1 that associate as a heter... | [
"GO:0004252",
"GO:0019028",
"GO:0055036"
] | [
"serine-type endopeptidase activity",
"viral capsid",
"virion membrane"
] | [
"molecular_function",
"cellular_component",
"cellular_component"
] | 3 | [
"PFAM"
] | [
"PF01589"
] | [
"Alpha_E1_glycop"
] | [
5077
] | 1 | [
"EC"
] | [
"3.4.21.90"
] | [
"EC:3.4.21.90"
] | 1 | [
"1i9w",
"1ld4",
"1rer",
"1z8y",
"2ala",
"2rsw",
"2v33",
"2xfb",
"2xfc",
"2yew",
"3j0c",
"3j0f",
"3j2w",
"3muu",
"3muw",
"3n40",
"3n41",
"3n42",
"3n43",
"3n44",
"5any",
"5vu2",
"6imm",
"6jo8",
"6mui",
"6mw9",
"6mwc",
"6mwv",
"6mwx",
"6mx4",
"6nk5",
"6nk6"... | 128 | [
"PUB00006300",
"PUB00015616",
"PUB00015617"
] | [
"8107141",
"11301009",
"15378043"
] | [
"The organization of the spike complex of Semliki Forest virus.",
"The Fusion glycoprotein shell of Semliki Forest virus: an icosahedral assembly primed for fusogenic activation at endosomal pH.",
"Transmission cycles, host range, evolution and emergence of arboviral disease."
] | [
1994,
2001,
2004
] | 3 | [] | [] | 0 | 0 | null | [
"Methylobacterium",
"Orthornavirae"
] | [
5,
5072
] | 2 | [] | [] | 0 | true | Domain | Alphavirus E1 glycoprotein | Alphavirus E1 glycoprotein | Alpha_E1_glycop | 6 |
IPR002549 | 2,549 | Transmembrane protein TqsA-like | AI-2E-like | Family | 82,581 | false | false | This entry consists of proteins from eukaryotes and prokarytotes. It includes Escherichia coli autoinducer-2 (AI-2) transport protein TqsA (YdgG), which controls the transport of the quorum-sensing signal AI-2 either by enhancing its secretion or inhibiting its uptake and consequently represses biofilm formation and mo... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF01594",
"PTHR21716"
] | [
"AI-2E_transport",
""
] | [
81193,
79372
] | 2 | [] | [] | [] | 0 | [
"7nb6",
"7ot9"
] | 2 | [
"PUB00012907",
"PUB00076989",
"PUB00076990",
"PUB00086646"
] | [
"12662922",
"20559013",
"16385049",
"28374790"
] | [
"The sigmaE regulon and the identification of additional sporulation genes in Bacillus subtilis.",
"The autoinducer-2 exporter superfamily.",
"YdgG (TqsA) controls biofilm formation in Escherichia coli K-12 through autoinducer 2 transport.",
"A UPF0118 family protein with uncharacterized function from the mod... | [
2003,
2010,
2006,
2017
] | 4 | [] | [
"IPR014227"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Myoviridae sp. ct9Ns12",
"unclassified sequences"
] | [
1974,
75646,
4107,
1,
853
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
4,
2,
2,
9,
4,
3,
4,
3,
6,
3
] | 10 | true | Family | Transmembrane protein TqsA-like | Transmembrane protein TqsA-like | AI-2E-like | 6 |
IPR002550 | 2,550 | CNNM, transmembrane domain | CNNM | Domain | 74,271 | false | false | Proteins containing the ancient conserved domain protein/cyclin M (CNNM) are integral membrane proteins that are conserved from bacteria to humans. CNNM family members influence metal ion homeostasis through mechanisms that may not involve direct membrane transport of the ions. Structurally, CNNMs are complex proteins ... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE"
] | [
"PF01595",
"PS51846"
] | [
"CNNM",
"CNNM"
] | [
73504,
72182
] | 2 | [] | [] | [] | 0 | [
"7cff",
"7cfg",
"7m1t",
"7m1u"
] | 4 | [
"PUB00088668",
"PUB00088669",
"PUB00088670",
"PUB00088671",
"PUB00098586"
] | [
"15498024",
"22399287",
"27856537",
"27899452",
"34188059"
] | [
"Manganese toxicity and Saccharomyces cerevisiae Mam3p, a member of the ACDP (ancient conserved domain protein) family.",
"Membrane topology and intracellular processing of cyclin M2 (CNNM2).",
"Phosphocysteine in the PRL-CNNM pathway mediates magnesium homeostasis.",
"Structural Basis of the Oncogenic Intera... | [
2005,
2012,
2016,
2017,
2021
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1630,
56867,
14816,
6,
952
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
41,
5,
20,
3,
2,
7,
8,
1,
16,
14,
1,
1,
45
] | 13 | true | Domain | CNNM, transmembrane domain | CNNM, transmembrane domain | CNNM | 5 |
IPR002551 | 2,551 | Spike glycoprotein S1, coronavirus | Spike_S1_CoV | Domain | 4,616 | false | false | The type I glycoprotein S of Coronavirus, trimers of which constitute the typical viral spikes, is assembled into virions through noncovalent interactions with the M protein. The spike glycoprotein is translated as a large polypeptide that is subsequently cleaved to S1 and S2 [ ]. Both chimeric S proteins appeared to c... | [
"GO:0019064"
] | [
"fusion of virus membrane with host plasma membrane"
] | [
"biological_process"
] | 1 | [
"PFAM"
] | [
"PF01600"
] | [
"CoV_S1"
] | [
4616
] | 1 | [
"GP"
] | [
"GenProp1009"
] | [
"GP:GenProp1009"
] | 1 | [
"3kbh",
"4f2m",
"4f5c",
"5szs",
"6atk",
"6b7n",
"6bfu",
"6jx7",
"6u7e",
"6u7f",
"6u7g",
"6u7h",
"6u7k",
"6vv5",
"7cyc",
"7cyd",
"7fc3",
"7kip",
"7u0l",
"7us6",
"7usa",
"7usb",
"7vn9",
"7vng",
"7vpp",
"7vpq",
"7w6m",
"7w73",
"7y6s",
"7y6t",
"7y6u",
"7y6v"... | 49 | [
"PUB00003124",
"PUB00006464",
"PUB00006522",
"PUB00079169",
"PUB00094057",
"PUB00094058"
] | [
"2984314",
"10627571",
"10725213",
"14647384",
"19906932",
"14670965"
] | [
"Cloning and sequencing of the gene encoding the spike protein of the coronavirus IBV.",
"Assembly of spikes into coronavirus particles is mediated by the carboxy-terminal domain of the spike protein.",
"Coronavirus-induced membrane fusion requires the cysteine-rich domain in the spike protein.",
"Angiotensin... | [
1985,
2000,
2000,
2003,
2010,
2004
] | 6 | [] | [] | 0 | 0 | null | [
"Coronaviridae",
"Sus scrofa"
] | [
4605,
11
] | 2 | [] | [] | 0 | true | Domain | Spike glycoprotein S1, coronavirus | Spike glycoprotein S1, coronavirus | Spike_S1_CoV | 9 |
IPR002552 | 2,552 | Spike glycoprotein S2, coronavirus | Spike_S2_CoV | Domain | 7,534 | false | false | The type I glycoprotein S of Coronavirus, trimers of which constitute the typical viral spikes, is assembled into virions through noncovalent interactions with the M protein. The spike glycoprotein is translated as a large polypeptide that is subsequently cleaved to S1 ( ) and S2 [ ]. The cleavage of S can occur at two... | [
"GO:0019064",
"GO:0039654",
"GO:0046813",
"GO:0075509",
"GO:0016020",
"GO:0019031",
"GO:0055036"
] | [
"fusion of virus membrane with host plasma membrane",
"fusion of virus membrane with host endosome membrane",
"receptor-mediated virion attachment to host cell",
"endocytosis involved in viral entry into host cell",
"membrane",
"viral envelope",
"virion membrane"
] | [
"biological_process",
"biological_process",
"biological_process",
"biological_process",
"cellular_component",
"cellular_component",
"cellular_component"
] | 7 | [
"PFAM"
] | [
"PF01601"
] | [
"CoV_S2"
] | [
7534
] | 1 | [
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"GenProp1009",
"R-HSA-9678110",
"R-HSA-9679509",
"R-HSA-9683686",
"R-HSA-9683701",
"R-HSA-9692916",
"R-HSA-9694322",
"R-HSA-9694548",
"R-HSA-9694614",
"R-HSA-9694635",
"R-HSA-9705671",
"R-HSA-9733458"
] | [
"GP:GenProp1009",
"REACTOME:R-HSA-9678110",
"REACTOME:R-HSA-9679509",
"REACTOME:R-HSA-9683686",
"REACTOME:R-HSA-9683701",
"REACTOME:R-HSA-9692916",
"REACTOME:R-HSA-9694322",
"REACTOME:R-HSA-9694548",
"REACTOME:R-HSA-9694614",
"REACTOME:R-HSA-9694635",
"REACTOME:R-HSA-9705671",
"REACTOME:R-HSA-... | 12 | [
"1wdf",
"1wdg",
"1wnc",
"1wyy",
"1zv8",
"1zva",
"2bez",
"2fxp",
"3jcl",
"4mod",
"4njl",
"5i08",
"5szs",
"5w9h",
"5w9i",
"5w9j",
"5w9k",
"5w9l",
"5w9m",
"5w9n",
"5w9o",
"5w9p",
"5wrg",
"5x58",
"5x59",
"5x5b",
"5x5c",
"5x5f",
"5xjk",
"5xlr",
"5yl9",
"5zhy"... | 1,583 | [
"PUB00003124",
"PUB00006464",
"PUB00006522",
"PUB00093087",
"PUB00094061",
"PUB00094063",
"PUB00094064",
"PUB00094114",
"PUB00099876"
] | [
"2984314",
"10627571",
"10725213",
"19321428",
"25445340",
"26206723",
"32057769",
"32150576",
"34580920"
] | [
"Cloning and sequencing of the gene encoding the spike protein of the coronavirus IBV.",
"Assembly of spikes into coronavirus particles is mediated by the carboxy-terminal domain of the spike protein.",
"Coronavirus-induced membrane fusion requires the cysteine-rich domain in the spike protein.",
"Activation ... | [
1985,
2000,
2000,
2009,
2015,
2015,
2020,
2020,
2021
] | 9 | [] | [
"IPR044873",
"IPR044874"
] | 0 | 2 | 0 | [
"Orthornavirae",
"Sus scrofa"
] | [
7524,
10
] | 2 | [] | [] | 0 | true | Domain | Spike glycoprotein S2, coronavirus | Spike glycoprotein S2, coronavirus | Spike_S2_CoV | 6 |
IPR002553 | 2,553 | Clathrin/coatomer adaptor, adaptin-like, N-terminal | Clathrin/coatomer_adapt-like_N | Domain | 56,305 | false | false | Proteins synthesized on the ribosome and processed in the endoplasmic reticulum are transported from the Golgi apparatus to the trans-Golgi network (TGN), and from there via small carrier vesicles to their final destination compartment. This traffic is bidirectional, to ensure that proteins required to form vesicles ar... | [
"GO:0006886",
"GO:0016192",
"GO:0030117"
] | [
"intracellular protein transport",
"vesicle-mediated transport",
"membrane coat"
] | [
"biological_process",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM"
] | [
"PF01602"
] | [
"Adaptin_N"
] | [
56305
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-177504",
"R-BTA-2132295",
"R-BTA-416993",
"R-BTA-432722",
"R-BTA-437239",
"R-BTA-5099900",
"R-BTA-5140745",
"R-BTA-6798695",
"R-BTA-6807878",
"R-BTA-6811434",
"R-BTA-8856825",
"R-BTA-8856828",
"R-BTA-8866427",
"R-BTA-8964038",
"R-CEL-6807878",
"R-CEL-6811434",
"R-DDI-432720",
... | [
"REACTOME:R-BTA-177504",
"REACTOME:R-BTA-2132295",
"REACTOME:R-BTA-416993",
"REACTOME:R-BTA-432722",
"REACTOME:R-BTA-437239",
"REACTOME:R-BTA-5099900",
"REACTOME:R-BTA-5140745",
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-6807878",
"REACTOME:R-BTA-6811434",
"REACTOME:R-BTA-8856825",
"REACTOME:R-... | 115 | [
"1w63",
"2jkr",
"2jkt",
"2vgl",
"2xa7",
"3tjz",
"4hmy",
"4nee",
"4p6z",
"4uqi",
"5a1u",
"5a1v",
"5a1w",
"5a1x",
"5a1y",
"5mu7",
"5nzr",
"5nzs",
"5nzt",
"5nzu",
"5nzv",
"6cm9",
"6cri",
"6d83",
"6d84",
"6dff",
"6owo",
"6owt",
"6oxl",
"6qh5",
"6qh6",
"6qh7"... | 67 | [
"PUB00004677",
"PUB00013972",
"PUB00029720",
"PUB00030524",
"PUB00035753",
"PUB00035768",
"PUB00035769"
] | [
"2495531",
"12086608",
"12858162",
"14690497",
"17449236",
"17041781",
"15261670"
] | [
"Structural and functional division into two domains of the large (100- to 115-kDa) chains of the clathrin-associated protein complex AP-2.",
"Molecular architecture and functional model of the endocytic AP2 complex.",
"Recognition of accessory protein motifs by the gamma-adaptin ear domain of GGA3.",
"Gamma-... | [
1989,
2002,
2003,
2004,
2007,
2006,
2004
] | 7 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriati",
"ecological metagenomes"
] | [
19,
56214,
70,
2
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
62,
12,
64,
23,
149,
61,
8,
40,
76,
8,
9,
263
] | 12 | true | Domain | Clathrin/coatomer adaptor, adaptin-like, N-terminal | Clathrin/coatomer adaptor, adaptin-like, N-terminal | Clathrin/coatomer_adapt-like_N | 8 |
IPR002554 | 2,554 | Protein phosphatase 2A, regulatory B subunit, B56 | PP2A_B56 | Family | 20,153 | false | false | Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism. The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit. There are multip... | [
"GO:0019888",
"GO:0007165",
"GO:0000159"
] | [
"protein phosphatase regulator activity",
"signal transduction",
"protein phosphatase type 2A complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PIRSF",
"PANTHER"
] | [
"PF01603",
"PIRSF028043",
"PTHR10257"
] | [
"B56",
"PP2A_B56",
""
] | [
20153,
16182,
19872
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-141444",
"R-BTA-195253",
"R-BTA-196299",
"R-BTA-2467813",
"R-BTA-2500257",
"R-BTA-389356",
"R-BTA-389513",
"R-BTA-432142",
"R-BTA-4641262",
"R-BTA-5663220",
"R-BTA-5673000",
"R-BTA-5675221",
"R-BTA-6811558",
"R-BTA-68877",
"R-BTA-9648025",
"R-CEL-195253",
"R-CEL-196299",
"R-... | [
"REACTOME:R-BTA-141444",
"REACTOME:R-BTA-195253",
"REACTOME:R-BTA-196299",
"REACTOME:R-BTA-2467813",
"REACTOME:R-BTA-2500257",
"REACTOME:R-BTA-389356",
"REACTOME:R-BTA-389513",
"REACTOME:R-BTA-432142",
"REACTOME:R-BTA-4641262",
"REACTOME:R-BTA-5663220",
"REACTOME:R-BTA-5673000",
"REACTOME:R-BT... | 97 | [
"2iae",
"2jak",
"2npp",
"2nyl",
"2nym",
"3fga",
"5jja",
"5k6s",
"5sw9",
"5swf",
"6nts",
"6oyl",
"6toq",
"6voy",
"6vro",
"7ouf",
"7oug",
"7ouh",
"7pel",
"7soy",
"8szk",
"8u1x",
"8u89",
"8uwb",
"9gnj",
"9mf5",
"9mip"
] | 27 | [
"PUB00002927"
] | [
"7592815"
] | [
"Identification of a new family of protein phosphatase 2A regulatory subunits."
] | [
1995
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
20153
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
34,
5,
13,
19,
34,
17,
1,
32,
20,
1,
2,
61
] | 12 | true | Family | Protein phosphatase 2A, regulatory B subunit, B56 | Protein phosphatase 2A, regulatory B subunit, B56 | PP2A_B56 | 4 |
IPR002556 | 2,556 | Arterivirus GP3 envelope glycoprotein | Arteri_GP3 | Family | 1,528 | false | false | This family consists of envelope proteins from Arterivirus, including glycoprotein 3 (GP3) from Porcine reproductive and respiratory syndrome virus (PRRSV) [ ] and Lactate dehydrogenase-elevating virus (LDV) structural glycoprotein [ ]. Arteriviruses consists of positive ssRNA and do not have a DNA stage. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01606"
] | [
"Arteri_env"
] | [
1528
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00003162",
"PUB00005610"
] | [
"8847527",
"7571421"
] | [
"Sequence comparison of open reading frames 2 to 5 of low and high virulence United States isolates of porcine reproductive and respiratory syndrome virus.",
"The envelope proteins of lactate dehydrogenase-elevating virus and their membrane topography."
] | [
1995,
1995
] | 2 | [] | [] | 0 | 0 | null | [
"Arteriviridae"
] | [
1528
] | 1 | [] | [] | 0 | true | Family | Arterivirus GP3 envelope glycoprotein | Arterivirus GP3 envelope glycoprotein | Arteri_GP3 | 4 |
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