LiteFold/InterPro · Datasets at Hugging Face

IPR002702

2,702

Translation repressor RegA

Transl_repress_RegA

Family

603

false

The translational regulator protein RegA, found in Bacteriophage T4 and related phages, binds to a region of messenger RNA (mRNA) that includes the initiator codon. RegA is unusual in that it represses the translation of about 35 early T4 mRNAs but does not affect nearly 200 other mRNAs [ ].

[ "GO:0003723" ]

[ "RNA binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF01818" ]

[ "Translat_reg" ]

[ 603 ]

1

[]

0

[ "1reg" ]

1

[ "PUB00005200" ]

[ "7761833" ]

[ "Crystal structure of the T4 regA translational regulator protein at 1.9 A resolution." ]

[ 1995 ]

1

[]

0

null

[ "Marine Group I thaumarchaeote", "Pseudomonadati", "Viruses", "metagenomes" ]

[ 7, 2, 561, 33 ]

4

[]

0

true

Family

Translation repressor RegA

Transl_repress_RegA

7

IPR002703

2,703

Levivirus coat protein

Levivir_coat

Family

668

false

This entry represents the coat proteins of the leviviruses (phage MS2) and alloleviruses (phage Qbeta and phage F1).

[ "GO:0005198", "GO:0019028" ]

[ "structural molecule activity", "viral capsid" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF01819" ]

[ "Levi_coat" ]

[ 668 ]

1

[]

0

[ "1aq3", "1aq4", "1bms", "1fr5", "1frs", "1gav", "1msc", "1mst", "1mva", "1mvb", "1qbe", "1u1y", "1una", "1zdh", "1zdi", "1zdj", "1zdk", "1zse", "2b2d", "2b2e", "2b2g", "2bny", "2bq5", "2bs0", "2bs1", "2bu1", "2c4q", "2c4y", "2c4z", "2c50", "2c51", "2iz8"...

96

[ "PUB00004192" ]

[ "7523953" ]

[ "Crystal structure of an RNA bacteriophage coat protein-operator complex." ]

[ 1994 ]

1

[]

0

null

[ "Viruses" ]

[ 668 ]

1

[]

0

true

Family

Levivirus coat protein

Levivir_coat

4

IPR002704

2,704

Peptidase C7 domain

Peptidase_C7_dom

Domain

219

false

This entry represents a peptidase C7 domain, which is found in HAV papain-like proteases p48 and p29 [ , ]. Hypoviruses are positive-strand RNA mycoviruses that attenuate virulence of their pathogenic fungal hosts [E1]. They employ a gene expression strategy that involves the autocatalytic processing of the N-terminal ...

[ "GO:0004197", "GO:0006508" ]

[ "cysteine-type endopeptidase activity", "proteolysis" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PROFILE" ]

[ "PF01830", "PS51877" ]

[ "Peptidase_C7", "HAV_P29_PRO" ]

[ 163, 219 ]

2

[]

0

[]

0

[ "PUB00070327", "PUB00070328", "PUB00094753", "PUB00094754", "PUB00094755", "PUB00094756" ]

[ "14557655", "8411354", "1853573", "25100848", "1918054", "18448523" ]

[ "Hypovirus papain-like protease p29 functions in trans to enhance viral double-stranded RNA accumulation and vertical transmission.", "Papain-like protease p29 as a symptom determinant encoded by a hypovirulence-associated virus of the chestnut blight fungus.", "The autocatalytic protease p29 encoded by a hypov...

[ 2003, 1993, 1991, 2014, 1991, 2008 ]

6

[]

0

null

[ "Orthornavirae" ]

[ 219 ]

1

[]

0

true

Domain

Peptidase C7 domain

Peptidase_C7_dom

5

IPR002705

2,705

Peptidase C30/C16, Betacoronavirus

Pept_C30/C16_B_coronavir

Domain

518

false

This entry represents a domain found in betacoronavirus cysteine endopeptidases that belong to MEROPS peptidase families C30 (clan PA) and C16 (subfamiles C16A and C16B, clan CA). These peptidase are involved in viral polyprotein processing. All coronaviruses encodes between one and two accessory cysteine proteinases t...

[ "GO:0003968", "GO:0008234", "GO:0006508" ]

[ "RNA-directed RNA polymerase activity", "cysteine-type peptidase activity", "proteolysis" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF01831" ]

[ "Peptidase_C16" ]

[ 518 ]

1

[ "EC", "EC", "EC", "METACYC" ]

[ "2.7.7.50", "3.4.19.12", "3.4.22.-", "PWY-7375" ]

[ "EC:2.7.7.50", "EC:3.4.19.12", "EC:3.4.22.-", "METACYC:PWY-7375" ]

4

[]

0

[ "PUB00011622", "PUB00011704", "PUB00017034", "PUB00017035", "PUB00020025", "PUB00030423", "PUB00076953" ]

[ "10725411", "11517925", "8396668", "12805436", "9891971", "14725770", "7044372" ]

[ "Virus-encoded proteinases and proteolytic processing in the Nidovirales.", "Evolutionary lines of cysteine peptidases.", "Identification of the catalytic sites of a papain-like cysteine proteinase of murine coronavirus.", "Identification of the murine coronavirus MP1 cleavage site recognized by papain-like p...

[ 2000, 2001, 1993, 2003, 1998, 2004, 1982 ]

7

[ "IPR013016" ]

[]

1

0

1

[ "Coronaviridae" ]

[ 518 ]

1

[]

0

true

Domain

Peptidase C30/C16, Betacoronavirus

Pept_C30/C16_B_coronavir

1

IPR002706

2,706

DNA-repair protein Xrcc1, N-terminal

Xrcc1_N

Domain

2,586

false

DNA-repair protein Xrcc1 functions in the repair of single-strand DNA breaks in mammalian cells and forms a repair complex with beta-Pol, ligase III and PARP [ ]. The NMR solution structure of the Xrcc1 N-terminal domain (Xrcc1 NTD) shows that the structural core is a β-sandwich with β-strands connected by loops, three...

[ "GO:0003684", "GO:0000012", "GO:0005634" ]

[ "damaged DNA binding", "single strand break repair", "nucleus" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF01834" ]

[ "XRCC1_N" ]

[ 2586 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-110381", "R-HSA-5649702", "R-HSA-5685939", "R-HSA-5696397", "R-HSA-6782210", "R-MMU-110381", "R-MMU-5649702", "R-MMU-5685939", "R-MMU-6782210", "R-RNO-110381", "R-RNO-5649702", "R-RNO-5685939", "R-RNO-6782210" ]

[ "REACTOME:R-HSA-110381", "REACTOME:R-HSA-5649702", "REACTOME:R-HSA-5685939", "REACTOME:R-HSA-5696397", "REACTOME:R-HSA-6782210", "REACTOME:R-MMU-110381", "REACTOME:R-MMU-5649702", "REACTOME:R-MMU-5685939", "REACTOME:R-MMU-6782210", "REACTOME:R-RNO-110381", "REACTOME:R-RNO-5649702", "REACTOME:R...

13

[ "1xna", "1xnt", "3k75", "3k77", "3lqc" ]

5

[ "PUB00005864", "PUB00005865" ]

[ "10467087", "10467102" ]

[ "Holding damaged DNA together.", "Solution structure of the single-strand break repair protein XRCC1 N-terminal domain." ]

[ 1999, 1999 ]

2

[]

0

null

[ "Eukaryota", "Pseudomonadati" ]

[ 2582, 4 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 2, 22, 15, 7 ]

5

true

Domain

DNA-repair protein Xrcc1, N-terminal

Xrcc1_N

9

IPR002708

2,708

Homocysteine biosynthesis enzyme, sulfur-incorporation

HcyBio

Domain

1,324

false

This presumed domain (used to be named as DUF39) is about is about 360 residues long. The function of this domain is not clear. It is found at N terminus in some proteins that have two C-terminal cystathionine beta-synthase (CBS) domains, such as MJ0100 from Methanocaldococcus jannaschii. This domain can also be found ...

[]

0

[ "PFAM" ]

[ "PF01837" ]

[ "HcyBio" ]

[ 1324 ]

1

[]

0

[]

0

[ "PUB00078766", "PUB00093781", "PUB00158972" ]

[ "25315403", "25938369", "30932481" ]

[ "Novel proteins for homocysteine biosynthesis in anaerobic microorganisms.", "Homocysteine is biosynthesized from aspartate semialdehyde and hydrogen sulfide in methanogenic archaea.", "Identification of an Enzyme Catalyzing the Conversion of Sulfoacetaldehyde to 2-Mercaptoethanesulfonic Acid in Methanogens." ]

[ 2014, 2015, 2019 ]

3

[]

0

null

[ "Aduncisulcus paluster", "Archaea", "Bacteria", "ecological metagenomes" ]

[ 1, 452, 761, 110 ]

4

[]

0

true

Domain

Homocysteine biosynthesis enzyme, sulfur-incorporation

HcyBio

1

IPR002711

2,711

HNH endonuclease

HNH

Domain

50,664

false

HNH endonuclease is found in bacteria and viruses [ , , ]. This entry represents the catalytic core of these enzymes that folds into a typical ββα-fold [ ]. It spans the conserved catalytic HNH motif and the Zn-binding site. This minimal catalytic core is found in site-specific homing endonucleases, restriction enzymes...

[ "GO:0003676", "GO:0004519", "GO:0008270" ]

[ "nucleic acid binding", "endonuclease activity", "zinc ion binding" ]

[ "molecular_function", "molecular_function", "molecular_function" ]

3

[ "PFAM" ]

[ "PF01844" ]

[ "HNH" ]

[ 50664 ]

1

[]

0

[ "4h9d", "4ogc", "4oge", "5h0m", "5h0o", "5mkw", "5zmm", "6ghc", "6me0", "6mec", "8d2k", "8d2l", "8d2n", "8d2o", "8d2p", "8d2q", "8fli", "8w1p", "8yb6", "8ydb", "8yeo", "8yh9", "8yha", "8z0k", "8z0l", "8zdy", "8zlu", "8zm3", "8znr", "8zol", "8zp7", "9ar5"...

33

[ "PUB00004482", "PUB00005727", "PUB00005734", "PUB00068885", "PUB00103794" ]

[ "9358175", "7920259", "7817395", "22745249", "28211904" ]

[ "Statistical modeling and analysis of the LAGLIDADG family of site-specific endonucleases and identification of an intein that encodes a site-specific endonuclease of the HNH family.", "Self-splicing group I and group II introns encode homologous (putative) DNA endonucleases of a new family.", "Amino acid seque...

[ 1997, 1994, 1994, 2012, 2017 ]

5

[ "IPR003615" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 850, 42522, 3384, 2471, 1437 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 14, 2, 2, 2, 1, 8, 3, 11 ]

8

true

Domain

HNH endonuclease

HNH

6

IPR002712

2,712

Toxin CcdB

CcdB

Family

2,878

false

CcdB protein is a topoisomerase poison from Escherichia coli [ ]. It is responsible for killing plasmid-free segregants, and interferes with the activity of DNA gyrase. It acts to inhibit partitioning of the chromosomal DNA.

[ "GO:0008657", "GO:0006276" ]

[ "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity", "plasmid maintenance" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF01845" ]

[ "CcdB" ]

[ 2878 ]

1

[ "GP" ]

[ "GenProp0321" ]

[ "GP:GenProp0321" ]

1

[ "1vub", "1x75", "2kmt", "2vub", "3g7z", "3hpw", "3jrz", "3jsc", "3tcj", "3vub", "4ely", "4elz", "4vub", "7epg", "7epi", "7epj" ]

16

[ "PUB00005844" ]

[ "9917404" ]

[ "Crystal structure of CcdB, a topoisomerase poison from E. coli." ]

[ 1999 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2851, 2, 25 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Toxin CcdB

CcdB

6

IPR002713

2,713

FF domain

FF_domain

Domain

16,145

false

The FF domain may be involved in protein-protein interaction [ ]. It often occurs as multiple copies and often accompanies WW domains . PRP40 from yeast encodes a novel, essential splicing component that associates with the yeast U1 small nuclear ribonucleoprotein particle [ ].

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF01846", "PS51676", "SM00441" ]

[ "FF", "FF", "FF" ]

[ 14108, 14150, 14403 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CFA-416550", "R-CFA-8849471", "R-CFA-8980692", "R-CFA-9013026", "R-CFA-9013106", "R-CFA-9013148", "R-CFA-9013149", "R-CFA-9013404", "R-CFA-9013405", "R-CFA-9013406", "R-CFA-9013408", "R-CFA-9013409", "R-CFA-9013423", "R-CFA-9696264", "R-CFA-9696270", "R-CFA-9696273", "R-DME-350407...

[ "REACTOME:R-CFA-416550", "REACTOME:R-CFA-8849471", "REACTOME:R-CFA-8980692", "REACTOME:R-CFA-9013026", "REACTOME:R-CFA-9013106", "REACTOME:R-CFA-9013148", "REACTOME:R-CFA-9013149", "REACTOME:R-CFA-9013404", "REACTOME:R-CFA-9013405", "REACTOME:R-CFA-9013406", "REACTOME:R-CFA-9013408", "REACTOME...

79

[ "1uzc", "2b7e", "2cqn", "2dod", "2doe", "2dof", "2e71", "2juc", "2k85", "2kfd", "2kiq", "2kis", "2kzg", "2l9v", "2lks", "3hfh", "4fqg", "6n7p", "7abf", "7abg", "7oqe", "8q7n", "8qo9" ]

23

[ "PUB00005857", "PUB00006345" ]

[ "10390614", "8622699" ]

[ "The FF domain: a novel motif that often accompanies WW domains.", "Identification of Prp40, a novel essential yeast splicing factor associated with the U1 small nuclear ribonucleoprotein particle." ]

[ 1999, 1996 ]

2

[]

[ "IPR032835" ]

0

1

0

[ "Bacteria", "Eukaryota" ]

[ 4, 16141 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 20, 5, 7, 14, 22, 20, 2, 8, 25, 2, 2, 59 ]

12

true

Domain

FF domain

FF_domain

5

IPR002715

2,715

Nascent polypeptide-associated complex NAC domain

Nas_poly-pep-assoc_cplx_dom

Domain

16,225

false

In eukaryotes, the Nascent polypeptide-Associated Complex (NAC) is a heterodimeric cytosolic protein complex composed of NAC alpha (NACA) and NAC beta (BTF3) [ ]. NAC binds reversibly to the ribosome where it is in contact with nascent chains as they emerge from the ribosome. But the cellular function of NAC seems to b...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF01849", "PS51151", "SM01407" ]

[ "NAC", "NAC_AB", "NAC" ]

[ 16160, 15963, 15701 ]

3

[ "PROSITEDOC" ]

[ "PDOC51151" ]

[ "PROSITEDOC:PDOC51151" ]

1

[ "1tr8", "3lkx", "3mcb", "3mce", "6t59", "7qwq", "7qwr", "7qws", "8p2k", "9f1b", "9f1c", "9f1d", "9fq0", "9mr4", "9ndp", "9qqa", "9qqb" ]

17

[ "PUB00005860", "PUB00031550", "PUB00033736", "PUB00061597", "PUB00097470" ]

[ "10413400", "15665334", "12475173", "21203952", "20214399" ]

[ "Comparative genomics of the Archaea (Euryarchaeota): evolution of conserved protein families, the stable core, and the variable shell.", "The crystal structure of archaeal nascent polypeptide-associated complex (NAC) reveals a unique fold and the presence of a ubiquitin-associated domain.", "Nascent-polypeptid...

[ 1999, 2005, 2002, 2010, 2010 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 911, 15, 15256, 43 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 26, 2, 11, 18, 24, 9, 2, 27, 27, 3, 2, 38 ]

12

true

Domain

Nascent polypeptide-associated complex NAC domain

Nas_poly-pep-assoc_cplx_dom

2

IPR002716

2,716

PIN domain

PIN_dom

Domain

108,878

false

PIN domains are small protein domains identified by the presence of three strictly conserved acidic residues. Apart from these three residues, there is poor sequence conservation [ ]. PIN domains are found in eukaryotes, eubacteria and archaea. In eukaryotes they are ribonucleases involved in nonsense mediated mRNA dec...

[]

0

[ "PFAM", "PFAM", "PFAM", "PFAM", "SMART" ]

[ "PF01850", "PF10130", "PF13470", "PF13638", "SM00670" ]

[ "PIN", "PIN_2", "PIN_3", "PIN_4", "PINc" ]

[ 66785, 668, 11537, 24189, 35530 ]

5

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-6791226", "R-CEL-429958", "R-CEL-450385", "R-CEL-450513", "R-CEL-9930044", "R-DDI-6791226", "R-DRE-975957", "R-HSA-380994", "R-HSA-429958", "R-HSA-450385", "R-HSA-450513", "R-HSA-450604", "R-HSA-6790901", "R-HSA-6791226", "R-HSA-975957", "R-HSA-9930044", "R-MMU-429958", "R-M...

[ "REACTOME:R-BTA-6791226", "REACTOME:R-CEL-429958", "REACTOME:R-CEL-450385", "REACTOME:R-CEL-450513", "REACTOME:R-CEL-9930044", "REACTOME:R-DDI-6791226", "REACTOME:R-DRE-975957", "REACTOME:R-HSA-380994", "REACTOME:R-HSA-429958", "REACTOME:R-HSA-450385", "REACTOME:R-HSA-450513", "REACTOME:R-HSA-...

31

[ "1o4w", "1v8o", "1v8p", "1w8i", "1y82", "2bsq", "2dok", "2fe1", "2h1c", "2h1o", "2hww", "2hwx", "2hwy", "2lcq", "2wp8", "3dbo", "3h87", "3i8o", "3ix7", "3tnd", "3zvk", "4chg", "4ifd", "4xgq", "4xgr", "5c0w", "5c0x", "5ecd", "5ecw", "5ecy", "5ed0", "5f4h"...

138

[ "PUB00041532", "PUB00059173", "PUB00067507" ]

[ "17053788", "21036780", "19706509" ]

[ "Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex.", "The PIN-domain ribonucleases and the prokaryotic VapBC toxin-antitoxin array.", "Nob1 binds the single-stranded cleavage site D at the 3'-end of 18S rRNA with its PIN domain." ]

[ 2006, 2011, 2009 ]

3

[]

[ "IPR037503", "IPR041120", "IPR041705", "IPR044153" ]

0

4

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 6571, 83794, 16533, 98, 1882 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 15, 6, 19, 14, 16, 14, 2, 12, 23, 7, 5, 43 ]

12

true

Domain

PIN domain

PIN_dom

1

IPR002717

2,717

Histone acetyltransferase domain, MYST-type

HAT_MYST-type

Domain

18,049

false

Histone acetyltransferases (HATs) fall into at least four different families based on sequence conservation within the HAT domain [ ]. The MYST family is the largest family of HATs and is named after the founding members: MOZ, Ybf2/ Sas3, Sas2 and Tip60. MYST proteins mediate many biological functions including gene re...

[ "GO:0004402", "GO:0006355" ]

[ "histone acetyltransferase activity", "regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PROFILE" ]

[ "PF01853", "PS51726" ]

[ "MOZ_SAS", "MYST_HAT" ]

[ 17765, 17990 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.3.1.48", "R-CEL-3214847", "R-CEL-5693607", "R-DME-201722", "R-DME-2559586", "R-DME-3214847", "R-DME-5693548", "R-DME-5693565", "R-DME-5693607", "R-DME-6804756", "R-DME-69473", "R-DME-9018519", "R-DME-9772755", "R-HSA-201722", "R-HSA-2559586", "R-HSA-3214847", "R-HSA-5685938", "R...

[ "EC:2.3.1.48", "REACTOME:R-CEL-3214847", "REACTOME:R-CEL-5693607", "REACTOME:R-DME-201722", "REACTOME:R-DME-2559586", "REACTOME:R-DME-3214847", "REACTOME:R-DME-5693548", "REACTOME:R-DME-5693565", "REACTOME:R-DME-5693607", "REACTOME:R-DME-6804756", "REACTOME:R-DME-69473", "REACTOME:R-DME-901851...

82

[ "1fy7", "1m36", "1mj9", "1mja", "1mjb", "2giv", "2ou2", "2ozu", "2pq8", "2rc4", "2y0m", "3qah", "3to6", "3to7", "3to9", "3toa", "3tob", "4dnc", "5gk9", "5j8c", "5j8f", "5j9q", "5j9t", "5j9u", "5j9w", "5wci", "6ba2", "6ba4", "6ct2", "6maj", "6mak", "6oin"...

65

[ "PUB00021631", "PUB00049312", "PUB00059116", "PUB00074632", "PUB00074636", "PUB00074637", "PUB00074823", "PUB00074824" ]

[ "11106757", "17925393", "22020126", "18722564", "21132344", "19303850", "22918831", "18245364" ]

[ "Crystal structure of yeast Esa1 suggests a unified mechanism for catalysis and substrate binding by histone acetyltransferases.", "The human monocytic leukemia zinc finger histone acetyltransferase domain contains DNA-binding activity implicated in chromatin targeting.", "MYST protein acetyltransferase activit...

[ 2000, 2007, 2012, 2009, 2011, 2009, 2012, 2008 ]

8

[]

0

null

[ "Christiangramia fulva", "Eukaryota", "bird metagenome" ]

[ 1, 18046, 2 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 8, 7, 30, 38, 50, 25, 3, 2, 31, 3, 2, 12 ]

12

true

Domain

Histone acetyltransferase domain, MYST-type

HAT_MYST-type

7

IPR002718

2,718

Outer membrane protein, Helicobacter

OMP_Helicobacter

Family

5,419

false

Gram-negative bacterial outer membranes constitute a semi-permeable, size-dependent permeability barrier, for example to hydrolytic enzymes, detergents, dyes and hydrophobic anti-microbials. The outer membrane protein (OMP) profile of Helicobacter pylori differs from that of other Gram-negative bacteria, where the high...

[]

0

[ "PFAM", "PRINTS" ]

[ "PF01856", "PR01776" ]

[ "HP_OMP", "HPOMPFAMILY" ]

[ 4995, 3902 ]

2

[]

0

[]

0

[ "PUB00005795", "PUB00011285" ]

[ "9252185", "9430586" ]

[ "The complete genome sequence of the gastric pathogen Helicobacter pylori.", "Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging." ]

[ 1997, 1998 ]

2

[]

0

null

[ "Pseudomonadati" ]

[ 5419 ]

1

[]

0

true

Family

Outer membrane protein, Helicobacter

OMP_Helicobacter

9

IPR002719

2,719

Retinoblastoma-associated protein, B-box

RB_B

Domain

6,378

false

This entry includes retinoblastoma-associated protein (RB, also known as pRb, RB, p1051), retinoblastoma-like protein 1 (RBL1, also known as p107) and retinoblastoma-like protein 2 (RBL2, also known as RB2 or p130). Members of this entry contain a conserved domain named the 'pocket' that interacts with the LXCXE motif ...

[ "GO:0051726", "GO:0005634" ]

[ "regulation of cell cycle", "nucleus" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF01857" ]

[ "RB_B" ]

[ 6378 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-1538133", "R-CEL-2173796", "R-CEL-69231", "R-DDI-113501", "R-DDI-1538133", "R-DDI-174178", "R-DDI-2299718", "R-DDI-69231", "R-DME-1538133", "R-DME-2173796", "R-DME-69231", "R-HSA-113501", "R-HSA-1362277", "R-HSA-1362300", "R-HSA-1538133", "R-HSA-174178", "R-HSA-2173796", "R-...

[ "REACTOME:R-CEL-1538133", "REACTOME:R-CEL-2173796", "REACTOME:R-CEL-69231", "REACTOME:R-DDI-113501", "REACTOME:R-DDI-1538133", "REACTOME:R-DDI-174178", "REACTOME:R-DDI-2299718", "REACTOME:R-DDI-69231", "REACTOME:R-DME-1538133", "REACTOME:R-DME-2173796", "REACTOME:R-DME-69231", "REACTOME:R-HSA-...

56

[ "1gh6", "1gux", "1n4m", "1o9k", "2r7g", "3pom", "4elj", "4ell", "4yoo", "4yos", "4yoz", "7smc", "7smd", "7sme", "7smf", "9dgk", "9dhc", "9dhf", "9dhu" ]

19

[ "PUB00004458", "PUB00005809", "PUB00067716", "PUB00067717", "PUB00067953", "PUB00067956", "PUB00067957", "PUB00067959", "PUB00067960", "PUB00067962" ]

[ "8152925", "9495340", "17531812", "17671431", "11018009", "12204530", "6320372", "11545733", "10630640", "17854503" ]

[ "Evidence for a protein domain superfamily shared by the cyclins, TFIIB and RB/p107.", "Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7.", "Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiesc...

[ 1994, 1998, 2007, 2007, 2000, 2002, 1984, 2001, 1999, 2007 ]

10

[]

0

null

[ "Eukaryota" ]

[ 6378 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 6, 1, 8, 3, 12, 11, 2, 14, 68 ]

9

true

Domain

Retinoblastoma-associated protein, B-box

RB_B

2

IPR002720

2,720

Retinoblastoma-associated protein, A-box

RB_A

Domain

6,602

false

null

[ "GO:0051726", "GO:0005634" ]

[ "regulation of cell cycle", "nucleus" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "SMART" ]

[ "PF01858", "SM01368" ]

[ "RB_A", "RB_A" ]

[ 6598, 6500 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-1538133", "R-CEL-2173796", "R-CEL-69231", "R-DDI-113501", "R-DDI-1538133", "R-DDI-174178", "R-DDI-2299718", "R-DDI-69231", "R-DME-1538133", "R-DME-2173796", "R-DME-69231", "R-HSA-113501", "R-HSA-1362277", "R-HSA-1362300", "R-HSA-1538133", "R-HSA-174178", "R-HSA-2173796", "R-...

[ "REACTOME:R-CEL-1538133", "REACTOME:R-CEL-2173796", "REACTOME:R-CEL-69231", "REACTOME:R-DDI-113501", "REACTOME:R-DDI-1538133", "REACTOME:R-DDI-174178", "REACTOME:R-DDI-2299718", "REACTOME:R-DDI-69231", "REACTOME:R-DME-1538133", "REACTOME:R-DME-2173796", "REACTOME:R-DME-69231", "REACTOME:R-HSA-...

56

[ "1ad6", "1gh6", "1gux", "1n4m", "1o9k", "2r7g", "3pom", "4elj", "4ell", "4yoo", "4yos", "4yoz", "7smc", "7smd", "7sme", "7smf", "9dgk", "9dhc", "9dhf", "9dhu" ]

20

[ "PUB00004458", "PUB00005809" ]

[ "8152925", "9495340" ]

[ "Evidence for a protein domain superfamily shared by the cyclins, TFIIB and RB/p107.", "Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7." ]

[ 1994, 1998 ]

2

[]

0

null

[ "Eukaryota" ]

[ 6602 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 6, 1, 8, 3, 19, 13, 2, 14, 68 ]

9

true

Domain

Retinoblastoma-associated protein, A-box

RB_A

9

IPR002723

2,723

N(4)-bis(aminopropyl)spermidine synthase, C-terminal

BpsA_C

Domain

1,267

false

This domain is found in the C terminus of N(4)-bis(aminopropyl)spermidine synthase (BpsA) from hyperthermophiles [ ] and in uncharacterised proteins from bacteria and archaea.

[]

0

[ "PFAM" ]

[ "PF01861" ]

[ "BpsA_C" ]

[ 1267 ]

1

[ "EC" ]

[ "2.5.1.128" ]

[ "EC:2.5.1.128" ]

1

[ "2qm3", "5xnc", "5xnf", "5xnh", "6j26", "6j27", "6j28" ]

7

[ "PUB00074302" ]

[ "24610711" ]

[ "Identification of a novel aminopropyltransferase involved in the synthesis of branched-chain polyamines in hyperthermophiles." ]

[ 2014 ]

1

[]

0

null

[ "Archaea", "Bacteria", "metagenomes" ]

[ 123, 1127, 17 ]

3

[]

0

true

Domain

N(4)-bis(aminopropyl)spermidine synthase, C-terminal

BpsA_C

9

IPR002724

2,724

Pyruvoyl-dependent arginine decarboxylase

Pyruvoyl-dep_arg_deCO2ase

Family

1,691

false

Arginine decarboxylase ( ) catalyses the interconversion of arginine and agmatine plus carbon dioxide [ ]. It requires a pyruvoyl group for its activity. Archaeoglobus fulgidus contains three copies of this 80-residue domain, all of which are very closely related.

[ "GO:0008792", "GO:0006527" ]

[ "arginine decarboxylase activity", "L-arginine catabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PFAM", "PIRSF", "PANTHER", "SFLD", "NCBIFAM" ]

[ "MF_01404", "PF01862", "PIRSF005216", "PTHR40438", "SFLDG01170", "TIGR00286" ]

[ "PvlArgDC", "PvlArgDC", "Pyruvoyl-dep_arg_deCO2ase", "", "Pyruvoyl-dependent_arginine_de", "" ]

[ 943, 1689, 982, 1618, 1622, 902 ]

6

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "4.1.1.19", "PWY-40", "PWY-43", "PWY-6834" ]

[ "EC:4.1.1.19", "METACYC:PWY-40", "METACYC:PWY-43", "METACYC:PWY-6834" ]

4

[ "1mt1", "1n13", "1n2m", "2qqc", "2qqd" ]

5

[ "PUB00027451" ]

[ "12623016" ]

[ "Pyruvoyl-dependent arginine decarboxylase from Methanococcus jannaschii: crystal structures of the self-cleaved and S53A proenzyme forms." ]

[ 2003 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 749, 831, 25, 86 ]

4

[]

0

true

Family

Pyruvoyl-dependent arginine decarboxylase

Pyruvoyl-dep_arg_deCO2ase

8

IPR002725

2,725

YgjP-like, metallopeptidase domain

YgjP-like_metallopeptidase

Domain

22,078

false

This is a conserved domain containing the catalytic zinc-metallopeptidase (HExxH) catalytic motif. Proteins containing this domain are found in some archaebacteria, as well as Helicobacter pylori. The proteins are 190-240 amino acids long, with the C terminus being the most conserved region, containing three conserved ...

[]

0

[ "PFAM" ]

[ "PF01863" ]

[ "YgjP-like" ]

[ 22078 ]

1

[]

0

[ "4jiu", "4jix" ]

2

[ "PUB00084997", "PUB00098014", "PUB00098015", "PUB00098016" ]

[ "27941785", "25802851", "23733187", "26257768" ]

[ "Nontargeted in vitro metabolomics for high-throughput identification of novel enzymes in Escherichia coli.", "MALDI-TOF MS and CD spectral analysis for identification and structure prediction of a purified, novel, organic solvent stable, fibrinolytic metalloprotease from Bacillus cereus B80.", "A novel family ...

[ 2017, 2015, 2013, 2015 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Myoviridae sp. ctWXg38", "unclassified sequences" ]

[ 490, 21114, 21, 1, 452 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

YgjP-like, metallopeptidase domain

YgjP-like_metallopeptidase

4

IPR002727

2,727

Protein of unknown function DUF47

DUF47

Family

2,749

false

This family includes prokaryotic proteins of unknown function, as well as a protein annotated as the pit accessory protein from Rhizobium meliloti (Sinorhizobium meliloti) ( ). However, while it has been hypothesised that this protein may play a role in orthophosphate transport (Pit stands for phosphate transport), its...

[]

0

[ "PANTHER", "NCBIFAM" ]

[ "PTHR36536", "TIGR00153" ]

[ "", "" ]

[ 2744, 2064 ]

2

[]

0

[ "2iiu", "2olt" ]

2

[ "PUB00005722" ]

[ "8013901" ]

[ "Second site mutations specifically suppress the Fix- phenotype of Rhizobium meliloti ndvF mutations on alfalfa: identification of a conditional ndvF-dependent mucoid colony phenotype." ]

[ 1994 ]

1

[ "IPR018445" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Ditylum brightwellii", "unclassified sequences" ]

[ 520, 2100, 1, 128 ]

4

[]

0

true

Family

Protein of unknown function DUF47

DUF47

6

IPR002729

2,729

CRISPR-associated protein Cas1

CRISPR-assoc_Cas1

Family

13,771

false

This entry represents Cas1, which is a metal-dependent DNA-specific endonuclease [ ]. Cas1 may play a role in the recognition, cleavage, and/or integration of foreign nucleic acids into CRISPRs. The CRISPR-Cas system is a prokaryotic defence mechanism against foreign genetic elements. The key elements of this defence s...

[ "GO:0003676", "GO:0004519", "GO:0046872", "GO:0043571", "GO:0051607" ]

[ "nucleic acid binding", "endonuclease activity", "metal ion binding", "maintenance of CRISPR repeat elements", "defense response to virus" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "biological_process" ]

5

[ "HAMAP", "PFAM", "NCBIFAM" ]

[ "MF_01470", "PF01867", "TIGR00287" ]

[ "Cas1", "Cas_Cas1", "cas1" ]

[ 12402, 13712, 12539 ]

3

[ "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP" ]

[ "GenProp0021", "GenProp0313", "GenProp0315", "GenProp0317", "GenProp0318", "GenProp0319", "GenProp0320", "GenProp0469", "GenProp0685", "GenProp0768", "GenProp1196" ]

[ "GP:GenProp0021", "GP:GenProp0313", "GP:GenProp0315", "GP:GenProp0317", "GP:GenProp0318", "GP:GenProp0319", "GP:GenProp0320", "GP:GenProp0469", "GP:GenProp0685", "GP:GenProp0768", "GP:GenProp1196" ]

11

[ "2yzs", "3god", "3nkd", "3nke", "4n06", "4p6i", "4qdl", "4w8k", "4wj0", "4xtk", "4zkj", "5dlj", "5dqt", "5dqu", "5dqz", "5ds4", "5ds5", "5ds6", "5fcl", "5vvj", "5vvk", "5vvl", "5wfe", "5xvn", "5xvo", "5xvp", "6kdv", "6ke1", "6opm", "6qxf", "6qxt", "6qy3"...

63

[ "PUB00043286", "PUB00043287", "PUB00043288", "PUB00052192", "PUB00060621", "PUB00071890" ]

[ "17442114", "17379808", "16545108", "19523907", "21699496", "24459147" ]

[ "Evolutionary conservation of sequence and secondary structures in CRISPR repeats.", "CRISPR provides acquired resistance against viruses in prokaryotes.", "A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with euka...

[ 2007, 2007, 2006, 2009, 2011, 2014 ]

6

[]

[ "IPR019851", "IPR019855", "IPR019856", "IPR019857", "IPR019858", "IPR023843", "IPR023844", "IPR027617", "IPR033641" ]

0

9

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified Mohonavirus", "unclassified sequences" ]

[ 805, 12737, 13, 2, 214 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

CRISPR-associated protein Cas1

CRISPR-assoc_Cas1

2

IPR002730

2,730

Ribonuclease P protein subunit Rpp29/RNP1

Rpp29/RNP1

Family

5,314

false

Ribonuclease P (Rnp) is a ubiquitous ribozyme that catalyzes a Mg2 -dependent hydrolysis to remove the 5'-leader sequence of precursor tRNA (pre-tRNA) in all three domains of life [ ]. In bacteria, the catalytic RNA (typically ~120kDa) is aided by a small protein cofactor (~14kDa) [ ]. Archaeal and eukaryote RNase P co...

[ "GO:0003723", "GO:0001682", "GO:0006396", "GO:0030677" ]

[ "RNA binding", "tRNA 5'-leader removal", "RNA processing", "ribonuclease P complex" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PFAM", "SMART" ]

[ "PF01868", "SM00538" ]

[ "RNase_P-MRP_p29", "POP4" ]

[ 5293, 4951 ]

2

[ "EC", "REACTOME" ]

[ "3.1.26.5", "R-HSA-6784531" ]

[ "EC:3.1.26.5", "REACTOME:R-HSA-6784531" ]

2

[ "1oqk", "1pc0", "1ts9", "1tsf", "1v76", "2ki7", "2zae", "6agb", "6ah3", "6ahr", "6ahu", "6k0a", "6k0b", "6w6v", "7c79", "7c7a" ]

16

[ "PUB00006321", "PUB00007201", "PUB00028005", "PUB00042726", "PUB00042727", "PUB00088366", "PUB00088367", "PUB00088368", "PUB00097414" ]

[ "7731988", "10024167", "14673079", "10352175", "15916546", "28971852", "21665995", "20627997", "21956908" ]

[ "The nucleotide sequence of chromosome I from Saccharomyces cerevisiae.", "Rpp14 and Rpp29, two protein subunits of human ribonuclease P.", "Structure of Mth11/Mth Rpp29, an essential protein subunit of archaeal and eukaryotic RNase P.", "hPop4: a new protein subunit of the human RNase MRP and RNase P ribonuc...

[ 1995, 1999, 2003, 1999, 2005, 2018, 2011, 2010, 2010 ]

9

[]

[ "IPR016848", "IPR023538" ]

0

2

0

[ "Archaea", "Eukaryota", "unclassified sequences" ]

[ 882, 4408, 24 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 2, 3, 4, 1, 1, 4, 2, 1, 1, 10 ]

12

true

Family

Ribonuclease P protein subunit Rpp29/RNP1

Rpp29/RNP1

9

IPR002731

2,731

ATPase, BadF/BadG/BcrA/BcrD type

ATPase_BadF

Domain

24,512

false

This domain is found in the BadF ( ) and BadG ( ) proteins that are two subunits of Benzoyl-CoA reductase, that may be involved in ATP hydrolysis. The family also includes an activase subunit from the enzyme 2-hydroxyglutaryl-CoA dehydratase ( ). The hypothetical protein AQ_278 from Aquifex aeolicus contains two copies...

[]

0

[ "PFAM" ]

[ "PF01869" ]

[ "BcrAD_BadFG" ]

[ 24512 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-446210", "R-MMU-446210", "R-RNO-446210" ]

[ "REACTOME:R-HSA-446210", "REACTOME:R-MMU-446210", "REACTOME:R-RNO-446210" ]

3

[ "1hux", "1zc6", "2ch5", "2ch6", "2e2n", "2e2o", "2e2p", "2e2q", "4eht", "4ehu", "4eia", "7yyl", "7yzm", "7yzq", "8zo3", "8zov", "8zpo" ]

17

[]

0

[]

[ "IPR008275" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified Caudoviricetes", "unclassified sequences" ]

[ 523, 20209, 3236, 2, 542 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 10, 1, 3, 1, 1, 7, 4, 5, 7, 9 ]

10

true

Domain

ATPase, BadF/BadG/BcrA/BcrD type

ATPase_BadF

8

IPR002732

2,732

Holliday junction resolvase Hjc

Hjc

Family

1,102

false

This entry represents Holliday junction resolvases (hjc gene) and related proteins, primarily from archaeal species [ ]. The Holliday junction is an essential intermediate of homologous recombination. Holliday junctions are four-stranded DNA complexes that are formed during recombination and related DNA repair events. ...

[]

0

[ "PFAM" ]

[ "PF01870" ]

[ "Hjc" ]

[ 1102 ]

1

[ "EC" ]

[ "3.1.21.10" ]

[ "EC:3.1.21.10" ]

1

[ "1gef", "1hh1", "1ipi", "1ob8", "1ob9", "2eo0", "2wcw", "2wcz", "2wiw", "2wiz", "2wj0", "4tkd", "4tkk" ]

13

[ "PUB00007198", "PUB00007199" ]

[ "10430863", "12126623" ]

[ "A Holliday junction resolvase from Pyrococcus furiosus: functional similarity to Escherichia coli RuvC provides evidence for conserved mechanism of homologous recombination in Bacteria, Eukarya, and Archaea.", "The inherent properties of DNA four-way junctions: comparing the crystal structures of holliday juncti...

[ 1999, 2002 ]

2

[]

[ "IPR014428" ]

0

1

0

[ "Archaea", "Bacteria", "Clonorchis sinensis", "Viruses", "metagenomes" ]

[ 825, 190, 1, 48, 38 ]

5

[]

0

true

Family

Holliday junction resolvase Hjc

Hjc

3

IPR002733

2,733

AMMECR1 domain

AMMECR1_domain

Domain

9,308

false

Nuclear protein AMMECR1, presently a protein of unknown function, is encoded by one of the genes affected by an X-linked deletion that causes the association of Alport syndrome, midface hypoplasia, intellectual disability and elliptocytosis in humans [ ]. This entry represents the C-terminal region of AMMECR1 (approxim...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF01871", "PS51112" ]

[ "AMMECR1", "AMMECR1" ]

[ 9261, 9194 ]

2

[ "PROSITEDOC" ]

[ "PDOC51112" ]

[ "PROSITEDOC:PDOC51112" ]

1

[ "1vaj", "1wsc", "1zq7" ]

3

[ "PUB00006433", "PUB00015590", "PUB00017067", "PUB00101144" ]

[ "10049589", "10828604", "15558565", "27811305" ]

[ "Identification and characterization of a highly conserved protein absent in the Alport syndrome (A), mental retardation (M), midface hypoplasia (M), and elliptocytosis (E) contiguous gene deletion syndrome (AMME).", "Identification and characterization of mouse orthologs of the AMMECR1 and FACL4 genes deleted in...

[ 1999, 2000, 2005, 2017 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Imitervirales", "unclassified sequences" ]

[ 814, 2749, 5519, 9, 217 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 1, 2, 14, 5, 1, 3, 7, 1, 1, 5 ]

12

true

Domain

AMMECR1 domain

AMMECR1_domain

1

IPR002734

2,734

Bacterial bifunctional deaminase-reductase, C-terminal

RibDG_C

Domain

76,746

false

This domain is found in the C terminus of the bifunctional deaminase-reductase of Escherichia coli, Bacillus subtilis and other bacteria in combination with that catalyses the second and third steps in the biosynthesis of riboflavin, i.e., the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (d...

[ "GO:0008703", "GO:0009231" ]

[ "5-amino-6-(5-phosphoribosylamino)uracil reductase activity", "riboflavin biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF01872" ]

[ "RibD_C" ]

[ 76746 ]

1

[ "EC" ]

[ "1.1.1" ]

[ "EC:1.1.1" ]

1

[ "2azn", "2b3z", "2d5n", "2g6v", "2gd9", "2hxv", "2o7p", "2obc", "2p4g", "2xw7", "3ex8", "3jtw", "3kgy", "3ky8", "3zpc", "3zpg", "4g3m", "4ha7", "4ha9", "4xrb", "4xt4", "4xt5", "4xt6", "4xt7", "4xt8", "5xux", "5xv0", "5xv2", "5xv5", "6de5", "6p8c", "7lrh"...

41

[ "PUB00006368" ]

[ "9068650" ]

[ "Biosynthesis of riboflavin: characterization of the bifunctional deaminase-reductase of Escherichia coli and Bacillus subtilis." ]

[ 1997 ]

1

[]

[ "IPR011549" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 1181, 71175, 3502, 4, 884 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 6, 1, 1, 5, 1, 1, 7 ]

7

true

Domain

Bacterial bifunctional deaminase-reductase, C-terminal

RibDG_C

5

IPR002735

2,735

Translation initiation factor IF2/IF5 domain

Transl_init_fac_IF2/IF5_dom

Domain

12,224

false

The beta subunit of archaeal and eukaryotic translation initiation factor 2 (IF2beta) and the N-terminal domain of translation initiation factor 5 (IF5) show significant sequence homology [ ]. Archaeal IF2beta contains two independent structural domains: an N-terminal mixed α/β core domain (topological similarity to th...

[ "GO:0003743", "GO:0006413" ]

[ "translation initiation factor activity", "translational initiation" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "SMART" ]

[ "PF01873", "SM00653" ]

[ "eIF-5_eIF-2B", "eIF2B_5" ]

[ 12214, 12094 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-156827", "R-CEL-381042", "R-CEL-382556", "R-CEL-72649", "R-CEL-72695", "R-CEL-72702", "R-CEL-72731", "R-CEL-9840373", "R-DDI-156827", "R-DDI-382556", "R-DDI-72695", "R-DDI-72702", "R-DDI-72731", "R-DDI-9840373", "R-DME-156827", "R-DME-381042", "R-DME-382556", "R-DME-72649", ...

[ "REACTOME:R-CEL-156827", "REACTOME:R-CEL-381042", "REACTOME:R-CEL-382556", "REACTOME:R-CEL-72649", "REACTOME:R-CEL-72695", "REACTOME:R-CEL-72702", "REACTOME:R-CEL-72731", "REACTOME:R-CEL-9840373", "REACTOME:R-DDI-156827", "REACTOME:R-DDI-382556", "REACTOME:R-DDI-72695", "REACTOME:R-DDI-72702",...

59

[ "1k81", "1k8b", "1nee", "2d74", "2dcu", "2e9h", "2g2k", "2nxu", "2qmu", "3cw2", "3j81", "3jap", "3v11", "5jb3", "5jbh", "6fyx", "6fyy", "6gsm", "6gsn", "6i3m", "6i7t", "6k71", "6k72", "6qg0", "6qg1", "6qg2", "6qg3", "6qg5", "6qg6", "6sw9", "6swc", "6ybv"...

54

[ "PUB00017012", "PUB00017014", "PUB00041778", "PUB00042630" ]

[ "11980477", "14978306", "16781736", "17608795" ]

[ "Structure of the beta subunit of translation initiation factor 2 from the archaeon Methanococcus jannaschii: a representative of the eIF2beta/eIF5 family of proteins.", "Structure of the archaeal translation initiation factor aIF2 beta from Methanobacterium thermoautotrophicum: implications for translation initi...

[ 2002, 2004, 2006, 2007 ]

4

[]

0

null

[ "Archaea", "Eukaryota", "Viruses", "metagenomes" ]

[ 1051, 11048, 56, 69 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 21, 2, 4, 3, 14, 15, 3, 12, 5, 2, 2, 25 ]

12

true

Domain

Translation initiation factor IF2/IF5 domain

Transl_init_fac_IF2/IF5_dom

5

IPR002736

2,736

Triphosphoribosyl-dephospho-CoA protein

CitG

Family

8,658

false

This entry represents the triphosphoribosyl-dephospho-CoA synthases CitG and MdcB. CitG and MdcB are closely related and produce the same molecule, triphosphoribosyl-dephospho-CoA, which becomes the prosthetic group of acyl carrier protein subunits of citrate lyase and malonate decarboxylase respectively [ , ].

[ "GO:0005524", "GO:0046917", "GO:0016310" ]

[ "ATP binding", "triphosphoribosyl-dephospho-CoA synthase activity", "phosphorylation" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM", "PANTHER" ]

[ "PF01874", "PTHR30201" ]

[ "CitG", "" ]

[ 8503, 7126 ]

2

[ "EC", "METACYC" ]

[ "2.4.2.52", "PWY-5796" ]

[ "EC:2.4.2.52", "METACYC:PWY-5796" ]

2

[ "3h9p" ]

1

[ "PUB00008049", "PUB00043058" ]

[ "11042274", "11052675" ]

[ "Identification of triphosphoribosyl-dephospho-CoA as precursor of the citrate lyase prosthetic group.", "Biosynthesis of triphosphoribosyl-dephospho-coenzyme A, the precursor of the prosthetic group of malonate decarboxylase." ]

[ 2000, 2000 ]

2

[]

[ "IPR017551", "IPR017555" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 740, 7843, 6, 69 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Triphosphoribosyl-dephospho-CoA protein

CitG

7

IPR002738

2,738

RNase P subunit p30

RNase_P_p30

Family

5,443

false

Members of this protein family are part of the ribonuclease P complex ( ) that takes part in endonucleolytic cleavage of RNA, removing 5'-extra-nucleotide from tRNA precursor. This process is essential for tRNA processing.

[ "GO:0008033" ]

[ "tRNA processing" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF01876", "PTHR13031" ]

[ "RNase_P_p30", "" ]

[ 5348, 4724 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.26.5", "R-BTA-6791226", "R-HSA-6784531", "R-HSA-6791226", "R-MMU-6791226" ]

[ "EC:3.1.26.5", "REACTOME:R-BTA-6791226", "REACTOME:R-HSA-6784531", "REACTOME:R-HSA-6791226", "REACTOME:R-MMU-6791226" ]

5

[ "1v77", "2czv", "3wyz", "3wz0", "6agb", "6ah3", "6ahr", "6ahu", "6k0a", "6k0b", "6w6v", "7c79", "7c7a" ]

13

[]

0

[]

[ "IPR023539" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 693, 7, 4731, 12 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 8, 2, 4, 1, 4, 4, 1, 7, 5, 1, 2, 4 ]

12

true

Family

RNase P subunit p30

RNase_P_p30

3

IPR002739

2,739

RNA-binding protein PAB1135-like

PAB1135-like

Family

1,657

false

This entry represents a family of archaeal proteins, including RNA-binding protein PAB1135 from Pyrococcus abyssi, UPF0201 protein PH1010 from Pyrococcus horikoshii and UPF0201 protein SSO1042 from Saccharolobus solfataricus. While PAB1135 has been reported to bind efficiently double-stranded RNAs in vitro in a non-seq...

[]

0

[ "HAMAP", "PFAM", "PANTHER" ]

[ "MF_01112", "PF01877", "PTHR39652" ]

[ "UPF0201", "RNA_binding", "" ]

[ 717, 1607, 785 ]

3

[]

0

[ "2nrq", "2nwu", "2ogk", "2pzz", "2wny", "3c9g", "3d7a" ]

7

[ "PUB00048377", "PUB00051274", "PUB00066786" ]

[ "19079550", "18831045", "20380716" ]

[ "UPF201 archaeal specific family members reveal structural similarity to RNA-binding proteins but low likelihood for RNA-binding function.", "Crystal structure of the DUF54 family protein PH1010 from hyperthermophilic archaea Pyrococcus horikoshii OT3.", "Expression, purification and structural analysis of the ...

[ 2008, 2009, 2010 ]

3

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 1627, 2, 28 ]

3

[]

0

true

Family

RNA-binding protein PAB1135-like

PAB1135-like

6

IPR002740

2,740

EVE domain

EVE_domain

Domain

14,050

false

The EVE domain is part of the wider PUA domain superfamily. The function of this domain is not known but, given the structural similarities to PUA, is likely to involve RNA binding [ ].

[]

0

[ "PFAM" ]

[ "PF01878" ]

[ "EVE" ]

[ 14050 ]

1

[]

0

[ "1wmm", "1zce", "2ar1", "2eve", "2g2x", "2gbs", "2hd9", "2p5d", "2zbn", "3eop", "5j3e" ]

11

[ "PUB00055624" ]

[ "19191354" ]

[ "Structural genomics reveals EVE as a new ASCH/PUA-related domain." ]

[ 2009 ]

1

[]

[ "IPR047197" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 354, 10089, 3413, 3, 191 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 4, 2, 1, 2, 1, 9, 6, 1, 3 ]

9

true

Domain

EVE domain

EVE_domain

6

IPR002742

2,742

Desulfoferrodoxin, ferrous iron-binding domain

Desulfoferrodoxin_Fe-bd_dom

Domain

3,205

false

Desulfoferrodoxins contains two types of iron: an Fe-S4 site very similar to that found in desulfoferrodoxin from Desulfovibrio gigas, and an octahedral coordinated high-spin ferrous site most probably with nitrogen/oxygen-containing ligands. Due to this rather unusual combination of active centres, this novel protein ...

[ "GO:0005506", "GO:0016491" ]

[ "iron ion binding", "oxidoreductase activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM", "NCBIFAM" ]

[ "PF01880", "TIGR00332" ]

[ "Desulfoferrodox", "neela_ferrous" ]

[ 3205, 2141 ]

2

[ "EC" ]

[ "1.15.1.2" ]

[ "EC:1.15.1.2" ]

1

[ "1dfx", "1do6", "1dqi", "1dqk", "1vzg", "1vzh", "1vzi", "1y07", "2amu", "2hvb", "2ji1", "2ji2", "2ji3", "3qzb", "4bff", "4bfj", "4bfk", "4bgl", "4bk8", "4brj", "4brv", "4c4b", "4c4u", "4d7p", "6gq8" ]

25

[ "PUB00005692", "PUB00014794", "PUB00014795" ]

[ "2174880", "8001576", "9914498" ]

[ "Purification and characterization of desulfoferrodoxin. A novel protein from Desulfovibrio desulfuricans (ATCC 27774) and from Desulfovibrio vulgaris (strain Hildenborough) that contains a distorted rubredoxin center and a mononuclear ferrous center.", "A blue non-heme iron protein from Desulfovibrio gigas.", ...

[ 1990, 1994, 1999 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 356, 2605, 89, 155 ]

4

[]

0

true

Domain

Desulfoferrodoxin, ferrous iron-binding domain

Desulfoferrodoxin_Fe-bd_dom

7

IPR002744

2,744

MIP18 family-like

MIP18-like

Domain

46,893

false

This domain (previously known as DUF59) is found in proteins that are mostly defined as members of the MIP18 family. This includes iron-sulfur cluster carrier proteins, where the domain is found in the N terminus. This domain is also found in protein AE7 from Arabidopsis and its homologues. Protein AE7 is thought to be...

[]

0

[ "PFAM" ]

[ "PF01883" ]

[ "FeS_assembly_P" ]

[ 46893 ]

1

[ "REACTOME" ]

[ "R-HSA-2564830" ]

[ "REACTOME:R-HSA-2564830" ]

1

[ "1uwd", "1wcj", "2cu6", "2m5h", "3cq1", "3cq2", "3cq3", "3lno", "3ux2", "3ux3", "5ird", "6tbl", "6tbn", "6tc0" ]

14

[ "PUB00069922", "PUB00085064", "PUB00085141" ]

[ "22678362", "23104832", "27517714" ]

[ "MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.", "The DUF59 family gene AE7 acts in the cytosolic iron-sulfur cluster assembly pathway to maintain nuclear genome integrity in Arabidopsis.", "The DUF59 Containing Protein SufT Is Involved in the Maturation of Iron-Sulfur ...

[ 2012, 2012, 2016 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctBLh2", "unclassified sequences" ]

[ 1733, 39048, 5219, 1, 892 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 7, 1, 1, 6, 1, 6, 2, 1, 4, 6, 1, 1, 12 ]

13

true

Domain

MIP18 family-like

MIP18-like

5

IPR002745

2,745

Phosphotransferase KptA/Tpt1

Ptrans_KptA/Tpt1

Family

10,294

false

This entry includes Tpt1 and its homologues from all domains of life. Tpt1 was first discovered as an essential component of the fungal tRNA splicing pathway, which characteristically generates a 2'-PO4, 3'-5' phosphodiester splice junction during the tRNA ligation reaction [ ]. It is an enzyme that catalyzes the trans...

[ "GO:0016740" ]

[ "transferase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER" ]

[ "PF01885", "PTHR12684" ]

[ "PTS_2-RNA", "" ]

[ 10269, 9519 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.7.1.-", "PWY-5129", "PWY-6322", "PWY-6369", "PWY-6626", "PWY-6682", "PWY-6955", "PWY-7077", "PWY-7321", "PWY-7740", "PWY-7769", "PWY-7886", "PWY-7948", "PWY-7975", "PWY-8129", "PWY-8324", "PWY-8367", "PWY-8392", "PWY-8393", "PWY-8394", "PWY-8402" ]

[ "EC:2.7.1.-", "METACYC:PWY-5129", "METACYC:PWY-6322", "METACYC:PWY-6369", "METACYC:PWY-6626", "METACYC:PWY-6682", "METACYC:PWY-6955", "METACYC:PWY-7077", "METACYC:PWY-7321", "METACYC:PWY-7740", "METACYC:PWY-7769", "METACYC:PWY-7886", "METACYC:PWY-7948", "METACYC:PWY-7975", "METACYC:PWY-8...

21

[ "1wfx", "6e3a", "6ede", "7kw8", "7kw9", "7yw2", "7yw3", "7yw4", "8tfi", "8tfx", "8tfy", "8tfz", "8tg3", "8tg4", "8tg5", "8tg6", "8tkb", "9ld3", "9ld4", "9ld6", "9lda", "9ldc", "9ldd", "9lde", "9ldf", "9ldg", "9ldh", "9ldi" ]

28

[ "PUB00094142", "PUB00094146", "PUB00094147", "PUB00094148" ]

[ "8392224", "30202863", "2154680", "31019096" ]

[ "An NAD derivative produced during transfer RNA splicing: ADP-ribose 1\"-2\" cyclic phosphate.", "NAD+-dependent synthesis of a 5'-phospho-ADP-ribosylated RNA/DNA cap by RNA 2'-phosphotransferase Tpt1.", "A highly specific phosphatase from Saccharomyces cerevisiae implicated in tRNA splicing.", "NAD+-dependen...

[ 1993, 2018, 1990, 2019 ]

4

[]

[ "IPR022928" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 331, 4604, 5255, 56, 48 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae...

[ 10, 3, 1, 1, 5, 1, 2, 2, 3, 1, 1, 17 ]

12

true

Family

Phosphotransferase KptA/Tpt1

Ptrans_KptA/Tpt1

4

IPR002746

2,746

Uncharacterised protein family UPF0216

UPF0216

Family

338

false

This Domain of unknown function 61 (DUF61) family of proteins are widely distributed in archaea. In crenarchaea, the genes of DUF61 proteins are in an operon containing two genes of box C/D RNA protein complexes. The NMR structure of a DUF61 family member from the hyperthermophilic archaeon Sulfolobus solfataricus reve...

[]

0

[ "HAMAP", "NCBIFAM", "PFAM", "PIRSF" ]

[ "MF_00585", "NF003153", "PF01886", "PIRSF005264" ]

[ "UPF0216", "PRK04115.1", "DUF61", "UCP005264" ]

[ 176, 178, 338, 155 ]

4

[]

0

[ "5vfk" ]

1

[ "PUB00098020" ]

[ "29526782" ]

[ "Solution structure of an archaeal DUF61 family protein SSO0941 encoded by a gene in the operon of box C/D RNA protein complexes." ]

[ 2018 ]

1

[]

0

null

[ "Archaea", "unclassified sequences" ]

[ 326, 12 ]

2

[]

0

true

Family

Uncharacterised protein family UPF0216

UPF0216

7

IPR002747

2,747

S-adenosyl-l-methionine hydroxide adenosyltransferase

SAM_OH_AdoTrfase

Family

6,308

false

The S-adenosyl-L-methionine (SAM) hydroxide adenosyltransferase family groups several fluorinase and chlorinase enzymes whose common feature is that they mediate nucleophilic reactions of their respective halide ions to the C-5' carbon of SAM [ ]. These enzymes utilise a rigorously conserved amino acid side chain triad...

[]

0

[ "PIRSF", "PANTHER" ]

[ "PIRSF006779", "PTHR35092" ]

[ "UCP006779", "" ]

[ 6043, 6308 ]

2

[]

0

[ "1rqp", "1rqr", "1wu8", "2c2w", "2c4t", "2c4u", "2c5b", "2c5h", "2cbx", "2cc2", "2cw5", "2f4n", "2q6i", "2q6k", "2q6l", "2q6o", "2v7t", "2v7u", "2v7v", "2v7w", "2v7x", "2wr8", "2zbu", "2zbv", "4cqj", "5b6i", "5fiu", "5lmz", "6ryz", "6rz2", "7ccg", "7xto"...

32

[ "PUB00030772", "PUB00039863", "PUB00047427", "PUB00048880", "PUB00049617", "PUB00054078", "PUB00056519", "PUB00101218", "PUB00151506" ]

[ "14765200", "16370017", "17910070", "18059261", "17985882", "18675376", "19739191", "32776704", "36996195" ]

[ "Crystal structure and mechanism of a bacterial fluorinating enzyme.", "The fluorinase from Streptomyces cattleya is also a chlorinase.", "Crystal structure of a conserved protein of unknown function (MJ1651) from Methanococcus jannaschii.", "Discovery and characterization of a marine bacterial SAM-dependent ...

[ 2004, 2006, 2008, 2008, 2007, 2008, 2009, 2020, 2023 ]

9

[]

[ "IPR030978" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 653, 5420, 27, 208 ]

4

[]

0

true

Family

S-adenosyl-l-methionine hydroxide adenosyltransferase

SAM_OH_AdoTrfase

4

IPR002748

2,748

Cobalt-precorrin-5B C(1)-methyltransferase CbiD

CbiD

Family

7,742

false

CbiD is a SAM-dependent methyltransferase essential for cobalamin biosynthesis in both Salmonella typhimurium and Bacillus megaterium [ ]. A deletion mutant of CbiD suggests that this enzyme is involved in C-1 methylation and deacylation reactions required during the ring contraction process in the anaerobic pathway to...

[ "GO:0008168", "GO:0009236" ]

[ "methyltransferase activity", "cobalamin biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PFAM", "PIRSF", "PANTHER", "NCBIFAM" ]

[ "MF_00787", "PF01888", "PIRSF026782", "PTHR35863", "TIGR00312" ]

[ "CbiD", "CbiD", "CbiD", "", "cbiD" ]

[ 7483, 7713, 6848, 7729, 7412 ]

5

[ "EC", "GP", "METACYC" ]

[ "2.1.1.195", "GenProp0275", "PWY-7377" ]

[ "EC:2.1.1.195", "GP:GenProp0275", "METACYC:PWY-7377" ]

3

[ "1sr8" ]

1

[ "PUB00000553", "PUB00009744", "PUB00014672", "PUB00015657", "PUB00035307", "PUB00035308", "PUB00035309", "PUB00035310", "PUB00070131" ]

[ "9742225", "11215515", "11153269", "12869542", "15741157", "17163662", "16042605", "12055304", "23922391" ]

[ "Cobalamin (vitamin B12) biosynthesis: identification and characterization of a Bacillus megaterium cobI operon.", "Biosynthesis of cobalamin (vitamin B12): a bacterial conundrum.", "Multiple biosynthetic pathways for vitamin B12: variations on a central theme.", "Comparative genomics of the vitamin B12 metab...

[ 1998, 2000, 2001, 2003, 2005, 2006, 2005, 2002, 2013 ]

9

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 406, 7225, 12, 99 ]

4

[]

0

true

Family

Cobalt-precorrin-5B C(1)-methyltransferase CbiD

CbiD

1

IPR002749

2,749

AliA/AliB-like

Family

1,155

false

This entry represents AliA (HVO_2859, ) and AliB (HVO_2611, ) from Haloferax volcanii and similar uncharacterised transmembrane proteins from archaea, including Uncharacterized 12.3 kDa protein in fus 3'region and Uncharacterized protein MJ0440. AliA and AliB (Ali stands for archaeal lipoprotein biogenesis components) ...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF01889", "PTHR40700" ]

[ "DUF63", "" ]

[ 1152, 1145 ]

2

[]

0

[]

0

[ "PUB00162475" ]

[ "40998839" ]

[ "Uncovering the prevalence, key biogenesis enzymes, and biological significance of archaeal lipoproteins." ]

[ 2025 ]

1

[]

0

null

[ "Archaea", "Candidatus Sungbacteria bacterium RIFCSPHIGHO2_02_FULL_49_12", "unclassified sequences" ]

[ 1135, 1, 19 ]

3

[]

0

true

Family

AliA/AliB-like

7

IPR002751

2,751

Metal transport protein CbiM/NikMN

CbiM/NikMN

Family

10,953

false

This entry represents the integral membrane protein CbiM, which forms part of the energy-coupling factor (ECF) transporter complex CbiMNOQ that is involved in cobalt import [ , ], and plays a role in the cobalamin synthesis pathway. CbiM is the substrate-specific component of the complex and is a seven-transmembrane pr...

[ "GO:0000041", "GO:0016020" ]

[ "transition metal ion transport", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF01891" ]

[ "CbiM" ]

[ 10953 ]

1

[ "GP" ]

[ "GenProp1094" ]

[ "GP:GenProp1094" ]

1

[ "4m58", "4m5b", "4m5c", "5x3x", "5x41" ]

5

[ "PUB00035607", "PUB00044396", "PUB00056802" ]

[ "16352848", "18174128", "20868747" ]

[ "Comparative and functional genomic analysis of prokaryotic nickel and cobalt uptake transporters: evidence for a novel group of ATP-binding cassette transporters.", "The complete coenzyme B12 biosynthesis gene cluster of Lactobacillus reuteri CRL1098.", "A bipartite S unit of an ECF-type cobalt transporter." ]

[ 2006, 2008, 2010 ]

3

[]

[ "IPR018024" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 794, 9964, 3, 192 ]

4

[]

0

true

Family

Metal transport protein CbiM/NikMN

CbiM/NikMN

8

IPR002753

2,753

Uncharacterised protein family UPF0058

UPF0058

Family

1,114

false

These archaebacterial proteins have no known function. Members of the family are about 90-105 amino acid residues long.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF01893", "PTHR42203" ]

[ "UPF0058", "" ]

[ 1114, 1034 ]

2

[]

0

[ "2gf4" ]

1

[]

0

[]

0

null

[ "Falsiroseomonas oleicola", "Methanobacteriota", "ecological metagenomes" ]

[ 1, 1104, 9 ]

3

[]

0

true

Family

Uncharacterised protein family UPF0058

UPF0058

6

IPR002755

2,755

DNA primase, small subunit

DNA_primase_S

Family

6,144

false

DNA primase synthesises the RNA primers for the Okazaki fragments in lagging strand DNA synthesis. DNA primase is a heterodimer of large and small subunits [ ]. This family represents the small subunit, and also includes baculovirus late expression factor 1 or LEF-1 proteins. Baculovirus LEF-1 is a DNA primase enzyme [...

[ "GO:0003899", "GO:0006269" ]

[ "DNA-directed RNA polymerase activity", "DNA replication, synthesis of primer" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF01896" ]

[ "DNA_primase_S" ]

[ 6144 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME...

[ "2.7.7", "2.7.7.-", "PWY-6322", "PWY-6626", "PWY-6749", "PWY-6955", "PWY-6998", "PWY-7127", "PWY-7419", "PWY-7529", "PWY-7706", "PWY-7719", "PWY-7735", "PWY-7737", "PWY-7769", "PWY-7888", "PWY-7904", "PWY-8117", "PWY-8179", "R-CEL-113501", "R-CEL-68952", "R-CEL-68962", "R...

[ "EC:2.7.7", "EC:2.7.7.-", "METACYC:PWY-6322", "METACYC:PWY-6626", "METACYC:PWY-6749", "METACYC:PWY-6955", "METACYC:PWY-6998", "METACYC:PWY-7127", "METACYC:PWY-7419", "METACYC:PWY-7529", "METACYC:PWY-7706", "METACYC:PWY-7719", "METACYC:PWY-7735", "METACYC:PWY-7737", "METACYC:PWY-7769", ...

66

[ "1g71", "1v33", "1v34", "1zt2", "4bpu", "4bpw", "4bpx", "4lik", "4lil", "4lim", "4mhq", "4mm2", "4rr2", "5exr", "5l2x", "5of3", "5ofn", "6r4s", "6r4t", "6r4u", "6r5d", "6r5e", "6rb4", "7jk1", "7jkl", "7jkp", "7jl8", "7jlg", "7opl", "7u5c", "7uy8", "8b9a"...

57

[ "PUB00005693", "PUB00010485" ]

[ "2023935", "11836407" ]

[ "Mutations in conserved yeast DNA primase domains impair DNA replication in vivo.", "Baculovirus replication factor LEF-1 is a DNA primase." ]

[ 1991, 2002 ]

2

[]

[ "IPR014052" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 924, 35, 5104, 40, 41 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 3, 2, 1, 10, 5, 1, 3, 9, 1, 1, 5 ]

12

true

Family

DNA primase, small subunit

DNA_primase_S

1

IPR002756

2,756

4-[[4-(2-aminoethyl)phenoxy]-methyl]-2-furanmethanamine-glutamate synthase

MfnF

Family

976

false

MfnF is a enzyme of the in the methanofuran biosynthetic pathway. It catalyses the coupling of F1-PP with gamma-glutamyltyramine to form APMF-Glu, the methanofuran core structure [ ]. MfnF exhibits a distinctive α/β two-layer sandwich structure that is different from the enzymes catalysing similar reactions.

[]

0

[ "NCBIFAM" ]

[ "TIGR03123" ]

[ "one_C_unchar_1" ]

[ 976 ]

1

[]

0

[ "3c0b", "3cet" ]

2

[ "PUB00077118" ]

[ "26100040" ]

[ "Identification of the Final Two Genes Functioning in Methanofuran Biosynthesis in Methanocaldococcus jannaschii." ]

[ 2015 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Cladocopium goreaui", "ecological metagenomes" ]

[ 264, 690, 1, 21 ]

4

[]

0

true

Family

4-[[4-(2-aminoethyl)phenoxy]-methyl]-2-furanmethanamine-glutamate synthase

MfnF

2

IPR002758

2,758

Na+/H+ antiporter subunit E

Cation_antiport_E

Family

13,526

false

This family contains both characterised and uncharacterised bacterial and archaeal proteins; some of which are possibly transmembrane proteins involved in Na + /H + or K + /H + transport. The characterised proteins are mnhE (Staphylococcus aureus) and PhaE (Rhizobium meliloti), which are subunits of the Na + /H + or K ...

[ "GO:0008324", "GO:0006812", "GO:0016020" ]

[ "monoatomic cation transmembrane transporter activity", "monoatomic cation transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF01899", "PIRSF019239", "PTHR34584" ]

[ "MNHE", "MrpE", "" ]

[ 13526, 7858, 13074 ]

3

[]

0

[ "6cfw", "6u8y", "6z16", "7d3u", "7qru" ]

5

[ "PUB00010583", "PUB00010603" ]

[ "9852009", "9680201" ]

[ "A putative multisubunit Na+/H+ antiporter from Staphylococcus aureus.", "The pha gene cluster of Rhizobium meliloti involved in pH adaptation and symbiosis encodes a novel type of K+ efflux system." ]

[ 1998, 1998 ]

2

[]

[ "IPR004847" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 849, 12497, 12, 168 ]

4

[]

0

true

Family

Na+/H+ antiporter subunit E

Cation_antiport_E

9

IPR002759

2,759

RNase P subunit Pop5/Rpp14/Rnp2-like

Pop5/Rpp14/Rnp2-like

Family

6,074

false

This entry contains ribonuclease P (Rnp) proteins from eukaryotes and archaea. Rnp is a ubiquitous ribozyme that catalyzes a Mg2 -dependent hydrolysis to remove the 5'-leader sequence of precursor tRNA (pre-tRNA) [ , ]. Archaeal and eukaryotic RNase P consist of a single RNA and archaeal RNase P has four or five protei...

[ "GO:0001682", "GO:0030677" ]

[ "tRNA 5'-leader removal", "ribonuclease P complex" ]

[ "biological_process", "cellular_component" ]

2

[ "HAMAP", "PFAM" ]

[ "MF_00755", "PF01900" ]

[ "RNase_P_2", "RNase_P_Rpp14" ]

[ 816, 6074 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.26.5", "R-HSA-6784531", "R-HSA-6791226", "R-MMU-6791226" ]

[ "EC:3.1.26.5", "REACTOME:R-HSA-6784531", "REACTOME:R-HSA-6791226", "REACTOME:R-MMU-6791226" ]

4

[ "2av5", "2czv", "3wz0", "6agb", "6ah3", "6ahr", "6ahu", "6k0a", "6k0b", "6w6v", "7c79", "7c7a" ]

12

[ "PUB00006321", "PUB00007201", "PUB00097410", "PUB00097413", "PUB00100655" ]

[ "7731988", "10024167", "16829535", "28715256", "30262633" ]

[ "The nucleotide sequence of chromosome I from Saccharomyces cerevisiae.", "Rpp14 and Rpp29, two protein subunits of human ribonuclease P.", "Characterization of the archaeal ribonuclease P proteins from Pyrococcus horikoshii OT3.", "Structural basis for activation of an archaeal ribonuclease P RNA by protein ...

[ 1995, 1999, 2006, 2017, 2018 ]

5

[]

[ "IPR016819" ]

0

1

0

[ "Archaea", "Eukaryota", "ecological metagenomes" ]

[ 765, 5286, 23 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 2, 1, 5, 6, 2, 2, 1, 9, 5, 1, 1, 3 ]

12

true

Family

RNase P subunit Pop5/Rpp14/Rnp2-like

Pop5/Rpp14/Rnp2-like

4

IPR002760

2,760

Putative O-antigen polymerase

O_anti_polymase

Family

391

false

This entry includes a group of archaebacterial proteins of unknown function. Members of this family may be transmembrane proteins. These are potentially O-antigen assembly enzymes, with up to 11 transmembrane regions.

[]

0

[ "PFAM" ]

[ "PF01901" ]

[ "O_anti_polymase" ]

[ 391 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Blastomyces silverae", "metagenomes" ]

[ 234, 152, 1, 4 ]

4

[]

0

true

Family

Putative O-antigen polymerase

O_anti_polymase

3

IPR002761

2,761

Diphthamide synthase domain

Diphthami_syn_dom

Domain

8,322

false

Diphthamide_syn, diphthamide synthase, catalyses the last amidation step of diphthamide biosynthesis using ammonium and ATP [ ]. Diphthamide synthase is evolutionarily conserved in eukaryotes. Diphthamide is a post-translationally modified histidine residue found on archaeal and eukaryotic translation elongation factor...

[]

0

[ "NCBIFAM", "CDD" ]

[ "TIGR00290", "cd01994" ]

[ "MJ0570_dom", "AANH_PF0828-like" ]

[ 7127, 8218 ]

2

[ "EC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "6.3.1.14", "PWY-6482", "PWY-7546", "R-BTA-5358493", "R-HSA-5358493", "R-MMU-5358493", "R-RNO-5358493", "R-SCE-5358493", "R-SPO-5358493" ]

[ "EC:6.3.1.14", "METACYC:PWY-6482", "METACYC:PWY-7546", "REACTOME:R-BTA-5358493", "REACTOME:R-HSA-5358493", "REACTOME:R-MMU-5358493", "REACTOME:R-RNO-5358493", "REACTOME:R-SCE-5358493", "REACTOME:R-SPO-5358493" ]

9

[ "2d13", "3rjz", "3rk0", "3rk1" ]

4

[ "PUB00016132", "PUB00073561" ]

[ "12012333", "23169644" ]

[ "Monophyly of class I aminoacyl tRNA synthetase, USPA, ETFP, photolyase, and PP-ATPase nucleotide-binding domains: implications for protein evolution in the RNA.", "Chemogenomic approach identified yeast YLR143W as diphthamide synthetase." ]

[ 2002, 2012 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 1011, 2417, 4827, 67 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 2, 6, 1, 3, 1, 1, 4, 10, 1, 1, 9 ]

12

true

Domain

Diphthamide synthase domain

Diphthami_syn_dom

3

IPR002762

2,762

Sirohydrochlorin cobaltochelatase CbiX-like

CbiX-like

Family

15,859

false

This entry represents sirohydrochlorin cobaltochelatase (also known as CbiX), which catalyses the insertion of Co2+ into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. The structure of CbiX from Archaeoglobus fulgidus consists of a central mixed β-sheet flanked by four α-helices, although ...

[ "GO:0016829" ]

[ "lyase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF01903" ]

[ "CbiX" ]

[ 15859 ]

1

[ "EC", "EC", "GP", "METACYC" ]

[ "4.99.1", "4.99.1.3", "GenProp0275", "PWY-7377" ]

[ "EC:4.99.1", "EC:4.99.1.3", "GP:GenProp0275", "METACYC:PWY-7377" ]

4

[ "1tjn", "2dj5", "2jh3", "2xwq", "2xws", "3lyh", "4ccs", "5zt7", "5zt8", "5zt9", "5zta", "6jv6", "6m25", "6m26", "6m27", "6m28", "6m29", "6m2a", "6m2e", "6m2f", "6m2g", "6m2h", "8i55", "8i56", "8i57", "8i58", "8iyu" ]

27

[ "PUB00014361", "PUB00035320" ]

[ "12686546", "16835730" ]

[ "A story of chelatase evolution: identification and characterization of a small 13-15-kDa \"ancestral\" cobaltochelatase (CbiXS) in the archaea.", "Crystal structure of the vitamin B12 biosynthetic cobaltochelatase, CbiXS, from Archaeoglobus fulgidus." ]

[ 2003, 2006 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1101, 13701, 905, 152 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 4, 15 ]

3

true

Family

Sirohydrochlorin cobaltochelatase CbiX-like

CbiX-like

8

IPR002763

2,763

Protein of unknown function DUF72

DUF72

Family

20,259

false

The function of this family is unknown. Aquifex aeolicus has two copies of this protein. A probable aspartyl-tRNA synthetase from Escherichia coli [ ] belongs to this group.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF01904", "PTHR30348" ]

[ "DUF72", "" ]

[ 20249, 19991 ]

2

[]

0

[ "1vpq", "1vpy", "1ztv" ]

3

[ "PUB00006256" ]

[ "2129559" ]

[ "Aspartyl-tRNA synthetase from Escherichia coli: cloning and characterisation of the gene, homologies of its translated amino acid sequence with asparaginyl- and lysyl-tRNA synthetases." ]

[ 1990 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 507, 19290, 246, 22, 194 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)" ]

[ 1, 1 ]

2

true

Family

Protein of unknown function DUF72

DUF72

2

IPR002764

2,764

CRISPR-associated protein Cas7/Cst2/DevR, subtype I-a/Apern

Cas7/Cst2/DevR_sub_I-a/Apern

Family

138

false

This entry represents the Cas7/Csa2 (CRISPR/Cas subtype protein 2) family of proteins, which form a stable complex with Cas5a that binds crRNA and complementary ssDNA [ ]. This archaeal clade is a member of the DevR family, which includes the DevR protein of Myxococcus xanthus, a protein whose expression appears to be ...

[]

0

[ "NCBIFAM" ]

[ "TIGR02583" ]

[ "DevR_archaea" ]

[ 138 ]

1

[ "GP", "GP" ]

[ "GenProp0021", "GenProp0319" ]

[ "GP:GenProp0021", "GP:GenProp0319" ]

2

[ "3ps0", "4reg", "7r21", "7r2k", "7tr6", "7tr8", "7tr9", "7tra", "9cp1", "9cp2", "9cp3", "9cro", "9crp", "9crq" ]

14

[ "PUB00020781", "PUB00043286", "PUB00043287", "PUB00043288", "PUB00060621", "PUB00071890", "PUB00078611" ]

[ "16292354", "17442114", "17379808", "16545108", "21699496", "24459147", "21507944" ]

[ "A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes.", "Evolutionary conservation of sequence and secondary structures in CRISPR repeats.", "CRISPR provides acquired resistance against viruses in prokaryotes.", "A putative RNA-interference-base...

[ 2005, 2007, 2007, 2006, 2011, 2014, 2011 ]

7

[ "IPR010154" ]

[]

1

0

1

[ "Archaea", "candidate division WOR-3 bacterium" ]

[ 137, 1 ]

2

[]

0

true

Family

CRISPR-associated protein Cas7/Cst2/DevR, subtype I-a/Apern

Cas7/Cst2/DevR_sub_I-a/Apern

4

IPR002765

2,765

Uncharacterised protein family UPF0145, YbjQ-like

UPF0145_YbjQ-like

Family

13,434

false

This entry represents a family of proteins from cellular organisms. Structural analysis suggest members of this group are likely to have a heavy-metal binding domain. The protein oligomerises as a pentamer [ ].

[]

0

[ "HAMAP", "PFAM", "PANTHER" ]

[ "MF_00338", "PF01906", "PTHR34068" ]

[ "UPF0145", "YbjQ_1", "" ]

[ 10232, 13433, 12591 ]

3

[]

0

[ "1vr4", "1y2i", "2gtc" ]

3

[ "PUB00101023" ]

[ "20944210" ]

[ "Structural classification of proteins and structural genomics: new insights into protein folding and evolution." ]

[ 2010 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes", "unclassified Caudoviricetes" ]

[ 541, 11825, 794, 272, 2 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family UPF0145, YbjQ-like

UPF0145_YbjQ-like

7

IPR002767

2,767

Thiamine-binding protein

Thiamine_BP

Domain

11,394

false

The crystal structure of two of these members shows that this domain has a ferredoxin like fold and is likely to exists as at least homodimers. Sulphate ions are located at the dimer interfaces, which are thought to confer additional stability. Although the function of this domain remains to be identified, its structur...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF01910", "TIGR00106" ]

[ "Thiamine_BP", "" ]

[ 11393, 6558 ]

2

[]

0

[ "1lxj", "1lxn", "1vk8", "1yqh", "2eky", "2epi", "2ibo" ]

7

[ "PUB00019479", "PUB00055842" ]

[ "12866058", "20471400" ]

[ "Crystal structures of MTH1187 and its yeast ortholog YBL001c.", "TM0486 from the hyperthermophilic anaerobe Thermotoga maritima is a thiamin-binding protein involved in response of the cell to oxidative conditions." ]

[ 2003, 2010 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "metagenomes" ]

[ 671, 8951, 4, 1674, 94 ]

5

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 2, 1 ]

2

true

Domain

Thiamine-binding protein

Thiamine_BP

3

IPR002769

2,769

Translation initiation factor IF6

eIF6

Family

6,110

false

This family includes eukaryotic translation initiation factor 6 (eIF6) as well as presumed archaeal homologues. The assembly of 80S ribosomes requires joining of the 40S and 60S subunits, which is triggered by the formation of an initiation complex on the 40S subunit. This event is rate-limiting for translation, and de...

[ "GO:0043022", "GO:0042256" ]

[ "ribosome binding", "cytosolic ribosome assembly" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PFAM", "PIRSF", "PANTHER", "SMART", "NCBIFAM", "CDD" ]

[ "MF_00032", "PF01912", "PIRSF006413", "PTHR10784", "SM00654", "TIGR00323", "cd00527" ]

[ "eIF_6", "eIF-6", "IF-6", "", "eIF6", "eIF-6", "IF6" ]

[ 5683, 6063, 4728, 6044, 5921, 5539, 4626 ]

7

[]

0

[ "1g61", "1g62", "2x7n", "3j2i", "3jct", "4adx", "4v7f", "4v8p", "5an9", "5anb", "5h4p", "5jcs", "5m3q", "5t62", "5z3g", "6c0f", "6elz", "6em1", "6em4", "6em5", "6ft6", "6lqm", "6lsr", "6lss", "6lu8", "6m62", "6n8j", "6n8k", "6n8l", "6n8m", "6n8n", "6n8o"...

153

[ "PUB00006155", "PUB00015905", "PUB00015906", "PUB00016064", "PUB00016185" ]

[ "9891075", "11238882", "9405604", "10206977", "11524672" ]

[ "The Saccharomyces cerevisiae homologue of mammalian translation initiation factor 6 does not function as a translation initiation factor.", "The Saccharomyces cerevisiae TIF6 gene encoding translation initiation factor 6 is required for 60S ribosomal subunit biogenesis.", "Molecular cloning and functional expr...

[ 1999, 2001, 1997, 1999, 2001 ]

5

[]

0

null

[ "Archaea", "Eukaryota", "candidate division TA06 bacterium DG_78", "unclassified sequences" ]

[ 923, 5143, 1, 43 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 3, 1, 7, 11, 1, 6, 5, 1, 1, 7 ]

12

true

Family

Translation initiation factor IF6

eIF6

3

IPR002770

2,770

Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr, C-terminal

ForMFR_H4MPT_ForTrfase_C

Domain

1,179

false

This entry represents the ferredoxin-like Ftr C-terminal domain. Formylmethanofuran:tetrahyromethanopterin formyltransferase (Ftr) is involved in C1 metabolism in methanogenic archaea, sulphate-reducing archaea and methylotrophic bacteria. It catalyses the following reversible reaction: N-formylmethanofuran + 5,6,7,8-t...

[ "GO:0016740", "GO:0006730" ]

[ "transferase activity", "one-carbon metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF02741" ]

[ "FTR_C" ]

[ 1179 ]

1

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "2.3.1.101", "PWY-5209", "PWY-7784", "PWY-8305" ]

[ "EC:2.3.1.101", "METACYC:PWY-5209", "METACYC:PWY-7784", "METACYC:PWY-8305" ]

4

[ "1ftr", "1m5h", "1m5s", "2fhj", "2fhk", "6s6y" ]

6

[ "PUB00005787", "PUB00016939", "PUB00016940" ]

[ "9195883", "12192072", "12123819" ]

[ "Formylmethanofuran: tetrahydromethanopterin formyltransferase from Methanopyrus kandleri - new insights into salt-dependence and thermostability.", "Crystal structures and enzymatic properties of three formyltransferases from archaea: environmental adaptation and evolutionary relationship.", "Generation of for...

[ 1997, 2002, 2002 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Cladocopium goreaui", "unclassified sequences" ]

[ 354, 773, 2, 50 ]

4

[]

0

true

Domain

Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr, C-terminal

ForMFR_H4MPT_ForTrfase_C

9

IPR002771

2,771

Multiple antibiotic resistance (MarC)-related

Multi_antbiot-R_MarC

Family

21,011

false

MarC is a protein that spans the plasma membrane multiple times and once was thought to be a multiple antibiotic resistance protein. The function for this family is unknown [ ].

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER", "NCBIFAM" ]

[ "PF01914", "PTHR33508", "TIGR00427" ]

[ "MarC", "", "" ]

[ 21010, 20903, 16915 ]

3

[]

0

[]

0

[ "PUB00077123" ]

[ "17954692" ]

[ "The marC gene of Escherichia coli is not involved in multiple antibiotic resistance." ]

[ 2008 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 576, 20076, 19, 340 ]

4

[ "Escherichia coli (strain K12)" ]

[ 3 ]

1

true

Family

Multiple antibiotic resistance (MarC)-related

Multi_antbiot-R_MarC

7

IPR002772

2,772

Glycoside hydrolase family 3 C-terminal domain

Glyco_hydro_3_C

Domain

78,735

false

Glycoside hydrolase family 3 comprises enzymes with a number of known activities; beta-glucosidase ( ); beta-xylosidase ( ); N-acetyl beta-glucosaminidase ( ); glucan beta-1,3-glucosidase ( ); cellodextrinase( ); exo-1,3-1,4-glucanase ( ). These enzymes are two-domain globular proteins that are N-glycosylated at three ...

[ "GO:0004553", "GO:0005975" ]

[ "hydrolase activity, hydrolyzing O-glycosyl compounds", "carbohydrate metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF01915" ]

[ "Glyco_hydro_3_C" ]

[ 78735 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "3.2.1", "3.2.1.21", "PWY-3121", "PWY-5176", "PWY-6002", "PWY-6788", "PWY-7091", "PWY-7092", "PWY-7913" ]

[ "EC:3.2.1", "EC:3.2.1.21", "METACYC:PWY-3121", "METACYC:PWY-5176", "METACYC:PWY-6002", "METACYC:PWY-6788", "METACYC:PWY-7091", "METACYC:PWY-7092", "METACYC:PWY-7913" ]

9

[ "1ex1", "1ieq", "1iev", "1iew", "1iex", "1j8v", "1lq2", "1x38", "1x39", "2x40", "2x41", "2x42", "3abz", "3ac0", "3bmx", "3lk6", "3nvd", "3rrx", "3u48", "3u4a", "3usz", "3ut0", "3wlh", "3wli", "3wlj", "3wlk", "3wll", "3wlm", "3wln", "3wlo", "3wlp", "3wlq"...

156

[ "PUB00005846" ]

[ "10368285" ]

[ "Three-dimensional structure of a barley beta-D-glucan exohydrolase, a family 3 glycosyl hydrolase." ]

[ 1999 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 482, 45184, 32656, 2, 411 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 83, 1, 9, 54, 1, 95 ]

6

true

Domain

Glycoside hydrolase family 3 C-terminal domain

Glyco_hydro_3_C

9

IPR002773

2,773

Deoxyhypusine synthase

Deoxyhypusine_synthase

Family

10,552

false

Eukaryotic initiation factor 5A (eIF-5A), now considered to be an elongation factor (see ), contains an unusual amino acid, hypusine [N epsilon-(4-aminobutyl-2-hydroxy)lysine]. The first step in the post-translational formation of hypusine is catalysed by the enzyme deoxyhypusine synthase (DS, ). The enzyme catalyses t...

[ "GO:0008612" ]

[ "peptidyl-lysine modification to peptidyl-hypusine" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER", "NCBIFAM" ]

[ "PF01916", "PTHR11703", "TIGR00321" ]

[ "DS", "", "dhys" ]

[ 10477, 10426, 4615 ]

3

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.5.1.46", "R-BTA-204626", "R-CEL-204626", "R-DDI-204626", "R-DME-204626", "R-HSA-204626", "R-MMU-204626", "R-RNO-204626", "R-SCE-204626", "R-SPO-204626" ]

[ "EC:2.5.1.46", "REACTOME:R-BTA-204626", "REACTOME:R-CEL-204626", "REACTOME:R-DDI-204626", "REACTOME:R-DME-204626", "REACTOME:R-HSA-204626", "REACTOME:R-MMU-204626", "REACTOME:R-RNO-204626", "REACTOME:R-SCE-204626", "REACTOME:R-SPO-204626" ]

10

[ "1dhs", "1rlz", "1roz", "1rqd", "6dft", "6p4v", "6pgr", "6w3z", "6wkz", "6wl6", "6xxh", "6xxi", "6xxj", "6xxk", "6xxl", "6xxm", "7a6s", "7a6t", "7cmc", "7l9r", "8a0e", "8a0f", "8a0g", "8put", "8pvu", "8qzw", "8qzx", "8r3u" ]

28

[ "PUB00005808" ]

[ "9493264" ]

[ "Crystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site." ]

[ 1998 ]

1

[]

[ "IPR022899", "IPR023496" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1300, 3056, 6027, 169 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 6, 2, 13, 3, 1, 8, 3, 1, 1, 11 ]

12

true

Family

Deoxyhypusine synthase

Deoxyhypusine_synthase

7

IPR002774

2,774

Flagellin, archaeal-type

Flagellin_arc-type

Family

2,587

false

This protein family represents archaeal Flagellin B1-B5 [ , ], Flagellin A-A2 [ , ] and similar proteins mainly found in archaea. A group of uncharacterised bacterial sequences is also included in this group. Archaeal motility occurs by the rotation of flagella that are different to bacterial flagella, but show similar...

[ "GO:0005198", "GO:0097588" ]

[ "structural molecule activity", "archaeal or bacterial-type flagellum-dependent cell motility" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER", "PANTHER" ]

[ "PF01917", "PTHR35903", "PTHR42200" ]

[ "Flagellin_arch-type", "", "" ]

[ 2462, 1573, 745 ]

3

[]

0

[ "5o4u", "5tfy", "5tug", "5tuh", "5ya6", "5z1l", "6pbk", "7ofq", "7txi", "8cwm", "8qx4", "8rh5", "9eq7", "9esm", "9ett", "9etu", "9i5h", "9r50" ]

18

[ "PUB00010517", "PUB00014343", "PUB00035904", "PUB00043526", "PUB00092687", "PUB00160948", "PUB00160949", "PUB00160950", "PUB00160951" ]

[ "11250034", "14622420", "16983194", "15170402", "10632878", "20363933", "23989184", "37399404", "38992036" ]

[ "The archaeal flagellum: a different kind of prokaryotic motility structure.", "Cleavage of preflagellins by an aspartic acid signal peptidase is essential for flagellation in the archaeon Methanococcus voltae.", "Archaeal flagella, bacterial flagella and type IV pili: a comparison of genes and posttranslationa...

[ 2001, 2003, 2006, 2004, 2000, 2010, 2013, 2023, 2024 ]

9

[]

[ "IPR016825" ]

0

1

0

[ "Archaea", "Bacteria", "metagenomes" ]

[ 2531, 20, 36 ]

3

[]

0

true

Family

Flagellin, archaeal-type

Flagellin_arc-type

4

IPR002775

2,775

DNA/RNA-binding protein Alba-like

DNA/RNA-bd_Alba-like

Domain

9,645

false

Members of this group include the archaeal protein Alba, eukaryotic RPP25L, Ribonucleases P/MRP protein subunit POP6 and Rpp25. The Alba domain is closely related to the RNA-binding versions of the IF3-C fold such as YhbY and IF3-C. The eukaryotic lineages of the Alba family are principally involved in RNA metabolism, ...

[ "GO:0003676" ]

[ "nucleic acid binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF01918" ]

[ "Alba" ]

[ 9645 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6784531", "R-HSA-6791226", "R-MMU-6791226", "R-RNO-6791226" ]

[ "REACTOME:R-HSA-6784531", "REACTOME:R-HSA-6791226", "REACTOME:R-MMU-6791226", "REACTOME:R-RNO-6791226" ]

4

[ "1h0x", "1h0y", "1nfh", "1nfj", "1nh9", "1udv", "1vm0", "1y9x", "2a2y", "2bky", "2h9u", "2q3v", "2z7c", "3iab", "3toe", "3u6y", "3wbm", "4z9e", "6agb", "6ah3", "6ahr", "6ahu", "6cwx", "6lt7", "6w6v", "7c79", "7c7a", "7dl8", "8xao", "8xap", "8xaq" ]

31

[ "PUB00015328", "PUB00019120", "PUB00028062" ]

[ "10869069", "14519199", "16256418" ]

[ "An abundant DNA binding protein from the hyperthermophilic archaeon Sulfolobus shibatae affects DNA supercoiling in a temperature-dependent fashion.", "The two faces of Alba: the evolutionary connection between proteins participating in chromatin structure and RNA metabolism.", "Archaeal chromatin proteins: di...

[ 2000, 2003, 2005 ]

3

[]

0

null

[ "Archaea", "Eukaryota", "candidate division WOR-3 bacterium", "unclassified sequences" ]

[ 852, 8709, 1, 83 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 31, 1, 5, 2, 2, 2, 1, 26, 4, 1, 82 ]

11

true

Domain

DNA/RNA-binding protein Alba-like

DNA/RNA-bd_Alba-like

9

IPR002778

2,778

Signal recognition particle, SRP19 subunit

Signal_recog_particle_SRP19

Family

5,548

false

The signal recognition particle (SRP) is a multimeric protein, which along with its conjugate receptor (SR), is involved in targeting secretory proteins to the rough endoplasmic reticulum (RER) membrane in eukaryotes, or to the plasma membrane in prokaryotes [ , , ]. SRP recognises the signal sequence of the nascent po...

[ "GO:0008312", "GO:0006614", "GO:0048500" ]

[ "7S RNA binding", "SRP-dependent cotranslational protein targeting to membrane", "signal recognition particle" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF01922", "PTHR17453" ]

[ "SRP19", "" ]

[ 5527, 5219 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-1799339", "R-CEL-1799339", "R-CFA-1799339", "R-DDI-1799339", "R-DME-1799339", "R-HSA-1799339", "R-MMU-1799339", "R-SCE-1799339", "R-SPO-1799339" ]

[ "REACTOME:R-BTA-1799339", "REACTOME:R-CEL-1799339", "REACTOME:R-CFA-1799339", "REACTOME:R-DDI-1799339", "REACTOME:R-DME-1799339", "REACTOME:R-HSA-1799339", "REACTOME:R-MMU-1799339", "REACTOME:R-SCE-1799339", "REACTOME:R-SPO-1799339" ]

9

[ "1jid", "1kvn", "1kvv", "1l9a", "1lng", "1mfq", "1ry1", "2go5", "2j37", "2v3c", "3dlu", "3dlv", "3jaj", "3jan", "3ktv", "3ktw", "3ndb", "4p3e", "4ue5", "4xco", "5m73", "6frk", "6r6g", "7nfx", "7obq", "7obr", "7qwq" ]

27

[ "PUB00028143", "PUB00035998", "PUB00035999", "PUB00036000", "PUB00053948", "PUB00063486", "PUB00100261" ]

[ "16469117", "17622352", "17507650", "17434535", "12364595", "12605305", "34020957" ]

[ "Human autoantibodies against the 54 kDa protein of the signal recognition particle block function at multiple stages.", "X-ray structures of the signal recognition particle receptor reveal targeting cycle intermediates.", "The signal recognition particle (SRP) RNA links conformational changes in the SRP to pro...

[ 2006, 2007, 2007, 2007, 2002, 2003, 2021 ]

7

[]

[ "IPR022938" ]

0

1

0

[ "Archaea", "Eukaryota", "ecological metagenomes" ]

[ 839, 4687, 22 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 1, 2, 6, 7, 1, 2, 5, 1, 2, 9 ]

12

true

Family

Signal recognition particle, SRP19 subunit

Signal_recog_particle_SRP19

8

IPR002780

2,780

Hydrogenase formation HypD protein

Hyd_form_HypD

Family

7,312

false

HypD is involved in the hyp operon which is needed for the activity of the three hydrogenase isoenzymes in Escherichia coli. HypD is one of the genes needed for formation of these enzymes [ ]. This protein has been found in Gram-negative and Gram-positive bacteria and Archaea. HypD contains many possible metal binding ...

[ "GO:0046872" ]

[ "metal ion binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PIRSF", "PANTHER", "NCBIFAM" ]

[ "PF01924", "PIRSF005622", "PTHR30149", "TIGR00075" ]

[ "HypD", "Hydrgn_mat_hypD", "", "hypD" ]

[ 7312, 6823, 7284, 7078 ]

4

[]

0

[ "2z1d", "3vyr", "3vys", "3vyt", "3vyu" ]

5

[ "PUB00005713", "PUB00015314" ]

[ "8326860", "1849603" ]

[ "Molecular analysis of a microaerobically induced operon required for hydrogenase synthesis in Rhizobium leguminosarum biovar viciae.", "Molecular characterization of an operon (hyp) necessary for the activity of the three hydrogenase isoenzymes in Escherichia coli." ]

[ 1993, 1991 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 408, 6703, 13, 188 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Hydrogenase formation HypD protein

Hyd_form_HypD

8

IPR002781

2,781

Transmembrane protein TauE-like, transmembrane domain

TM_pro_TauE-like

Domain

98,917

false

This entry includes integral membrane proteins containing transmembrane helices. This entry used to be known as DUF81. The TauE proteins are involved in the transport of anions across the cytoplasmic membrane [ , ] during taurine metabolism as an exporter of sulfoacetate [ ].

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF01925" ]

[ "TauE" ]

[ 98917 ]

1

[]

0

[]

0

[ "PUB00060436", "PUB00060437", "PUB00087318" ]

[ "17768248", "18506422", "22797525" ]

[ "The DUF81 protein TauE in Cupriavidus necator H16, a sulfite exporter in the metabolism of C2 sulfonates.", "Sulfoacetate released during the assimilation of taurine-nitrogen by Neptuniibacter caesariensis: purification of sulfoacetaldehyde dehydrogenase.", "(R)-Cysteate-nitrogen assimilation by Cupriavidus ne...

[ 2007, 2008, 2012 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Sym plasmid", "Viruses", "unclassified sequences" ]

[ 2016, 88661, 6531, 1, 15, 1693 ]

6

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 26, 5, 1, 20, 21 ]

5

true

Domain

Transmembrane protein TauE-like, transmembrane domain

TM_pro_TauE-like

5

IPR002782

2,782

Mut7-C RNAse domain

Mut7-C_RNAse_dom

Domain

6,263

false

This entry represents an RNAse domain of the PIN fold [ ] with an inserted zinc ribbon at the C terminus of probable exonuclease mut-7 [ ].

[]

0

[ "PFAM" ]

[ "PF01927" ]

[ "Mut7-C" ]

[ 6263 ]

1

[]

0

[ "8q66" ]

1

[ "PUB00034476", "PUB00066661" ]

[ "16859499", "11917006" ]

[ "The prokaryotic antecedents of the ubiquitin-signaling system and the early evolution of ubiquitin-like beta-grasp domains.", "Comparative genomics and evolution of proteins involved in RNA metabolism." ]

[ 2006, 2002 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 628, 2863, 2693, 79 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 7, 1, 3, 1, 4, 8 ]

6

true

Domain

Mut7-C RNAse domain

Mut7-C_RNAse_dom

2

IPR002784

2,784

Large ribosomal subunit protein eL14 domain

Ribosomal_eL14_dom

Domain

6,658

false

This entry includes the eukaryotic large ribosomal subunit protein eL14, which binds to the 60S ribosomal subunit. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amin...

[ "GO:0003735", "GO:0006412", "GO:0005840" ]

[ "structural constituent of ribosome", "translation", "ribosome" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF01929" ]

[ "Ribosomal_L14e" ]

[ 6658 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DDI-156827", "R-DDI-1799339", "R-DDI-72689", "R-DDI-72706", "R-DDI-975956", "R-DDI-975957", "R-DME-156827", "R-DME-1799339", "R-DME-72689", "R-DME-72706", "R-DME-975956", "R-DME-975957", "R-HSA-156827", "R-HSA-156902", "R-HSA-1799339", "R-HSA-192823", "R-HSA-2408557", "R-HSA-679...

[ "REACTOME:R-DDI-156827", "REACTOME:R-DDI-1799339", "REACTOME:R-DDI-72689", "REACTOME:R-DDI-72706", "REACTOME:R-DDI-975956", "REACTOME:R-DDI-975957", "REACTOME:R-DME-156827", "REACTOME:R-DME-1799339", "REACTOME:R-DME-72689", "REACTOME:R-DME-72706", "REACTOME:R-DME-975956", "REACTOME:R-DME-97595...

51

[ "3j6x", "3j6y", "3j77", "3j78", "3j79", "3j7o", "3j7p", "3j7q", "3j7r", "3j92", "3jag", "3jah", "3jai", "3jaj", "3jan", "3jbn", "3jbo", "3jbp", "3jcs", "3jct", "4adx", "4d5y", "4d67", "4u3m", "4u3n", "4u3u", "4u4n", "4u4o", "4u4q", "4u4r", "4u4u", "4u4y"...

580

[ "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "11297922", "11290319", "11114498" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins." ]

[ 2001, 2001, 2000 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Promethearchaeum syntrophicum" ]

[ 3, 6654, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 2, 4, 7, 4, 1, 5, 12, 2, 1, 16 ]

12

true

Domain

Large ribosomal subunit protein eL14 domain

Ribosomal_eL14_dom

7

IPR002789

2,789

Helicase HerA, central domain

HerA_central

Domain

17,576

false

This entry represents the central domain of archaeal protein HerA, which is a DNA helicase able to utilise either 3' or 5' single-stranded DNA extensions for loading and subsequent DNA duplex unwinding [ ]. It forms a complex with NurA nuclease, this complex has the 5'-3' DNA end resection activity and is essential for...

[]

0

[ "PFAM" ]

[ "PF01935" ]

[ "DUF87" ]

[ 17576 ]

1

[ "EC", "EC" ]

[ "5.6.2.3", "5.6.2.4" ]

[ "EC:5.6.2.3", "EC:5.6.2.4" ]

2

[ "4d2i", "7es4", "8j4u", "8su9", "8sub", "8suw", "8uae", "8uaf", "8wet", "8wfd", "8wiv", "8wj3", "8wk0", "8wld", "8woc", "8wod", "8wof", "8xau", "8xav", "8xaw", "8xax", "8xay", "8y1k", "8yho", "8yhx", "8ziq", "8zir", "8zis", "8zit", "9c1m", "9c1n", "9c1o"...

33

[ "PUB00076694", "PUB00076695", "PUB00078094", "PUB00094301" ]

[ "14990749", "25880130", "25420454", "18243819" ]

[ "A bipolar DNA helicase gene, herA, clusters with rad50, mre11 and nurA genes in thermophilic archaea.", "Efficient 5'-3' DNA end resection by HerA and NurA is essential for cell viability in the crenarchaeon Sulfolobus islandicus.", "Structure of the hexameric HerA ATPase reveals a mechanism of translocation-c...

[ 2004, 2015, 2014, 2008 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 2975, 14236, 23, 24, 318 ]

5

[]

0

true

Domain

Helicase HerA, central domain

HerA_central

9

IPR002790

2,790

Conserved hypothetical protein CHP00288

CHP00288

Family

274

false

This entry describes archaeal proteins of unknown function. This family of orthologues is restricted to, but universal among, the completed archaeal genomes so far. Eubacterial proteins showing at least local homology include slr1870 from Synechocystis sp. (strain PCC 6803) and two proteins from Aquifex aeolicus, none ...

[]

0

[ "NCBIFAM" ]

[ "TIGR00288" ]

[ "" ]

[ 274 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "ecological metagenomes" ]

[ 271, 3 ]

2

[]

0

true

Family

Conserved hypothetical protein CHP00288

CHP00288

9

IPR002791

2,791

Damage-control phosphatase ARMT1-like, metal-binding domain

ARMT1-like_metal-bd

Domain

11,115

false

This domain is found in Damage-control phosphatases ARMT1, YMR027W from S. cerevisiae ( ) and At2g17340 from Arabidopsis thaliana, and it is also found at the C-terminal portion of eukaryotic pantothenate kinases [ , ]. Despite the characterization of ARMT1 as a carboxyl methyltransferase, a second study suggests that ...

[]

0

[ "PFAM" ]

[ "PF01937" ]

[ "ARMT1-like_dom" ]

[ 11115 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "3.1.3.-", "PWY-4702", "PWY-5491", "PWY-6148", "PWY-6352", "PWY-6365", "PWY-6366", "PWY-6368", "PWY-6456", "PWY-6575", "PWY-6627", "PWY-6664", "PWY-6686", "PWY-6720", "PWY-6724", "PWY-6955", "PWY-6990", "PWY-6991", "PWY-7018", "PWY-7119", "PWY-7321", "PWY-7531", "PWY-7771...

[ "EC:3.1.3.-", "METACYC:PWY-4702", "METACYC:PWY-5491", "METACYC:PWY-6148", "METACYC:PWY-6352", "METACYC:PWY-6365", "METACYC:PWY-6366", "METACYC:PWY-6368", "METACYC:PWY-6456", "METACYC:PWY-6575", "METACYC:PWY-6627", "METACYC:PWY-6664", "METACYC:PWY-6686", "METACYC:PWY-6720", "METACYC:PWY-6...

39

[ "1xfi", "2ffj", "2g8l", "2q40", "3pt1", "5by0", "5f13", "6umq", "6umr", "7t7k", "7t7n", "7t7o", "7u1v", "7u1x", "7u1y", "8tkz" ]

16

[ "PUB00038288", "PUB00088731", "PUB00088733" ]

[ "16511115", "25732820", "27322068" ]

[ "The structure at 1.7 A resolution of the protein product of the At2g17340 gene from Arabidopsis thaliana.", "Human C6orf211 encodes Armt1, a protein carboxyl methyltransferase that targets PCNA and is linked to the DNA damage response.", "A family of metal-dependent phosphatases implicated in metabolite damage...

[ 2005, 2015, 2016 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 416, 1843, 8731, 125 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 21, 2, 11, 18, 9, 4, 1, 5, 10, 1, 2, 16 ]

12

true

Domain

Damage-control phosphatase ARMT1-like, metal-binding domain

ARMT1-like_metal-bd

4

IPR002792

2,792

TRAM domain

TRAM_dom

Domain

81,587

false

The TRAM (after TRM2 and miaB) domain is a 60-70-residue-long module that is found in: Two distinct classes of tRNA-modifying enzymes, namely uridine methylases of the TRM2 family and enzymes of the miaB family that are involved in 2- methylthioadenine formation In several other proteins associated with the translation...

[]

0

[ "PFAM", "PFAM", "PROFILE" ]

[ "PF01938", "PF18693", "PS50926" ]

[ "TRAM", "TRAM_2", "TRAM" ]

[ 50458, 16335, 78860 ]

3

[ "EC", "PROSITEDOC", "REACTOME" ]

[ "2.8.4", "PDOC50926", "R-HSA-6782315" ]

[ "EC:2.8.4", "PROSITEDOC:PDOC50926", "REACTOME:R-HSA-6782315" ]

3

[ "1uwv", "1yez", "1yvc", "2bh2", "2qgq", "4jc0", "5xj1", "5xj2", "5zq0", "5zq1", "5zq8", "5zth", "7mjv", "7mjw", "7mjx", "7mjy", "7mjz" ]

17

[ "PUB00009729", "PUB00158982" ]

[ "11313137", "31404065" ]

[ "TRAM, a predicted RNA-binding domain, common to tRNA uracil methylation and adenine thiolation enzymes.", "The archaeal RNA chaperone TRAM0076 shapes the transcriptome and optimizes the growth of Methanococcus maripaludis." ]

[ 2001, 2019 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 3772, 69154, 4, 7046, 1611 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 13, 3, 4, 2, 3, 7, 2, 1, 8, 9, 1, 1, 12 ]

13

true

Domain

TRAM domain

TRAM_dom

5

IPR002793

2,793

Endonuclease NucS

Endonuclease_NucS

Family

5,828

false

Endonuclease NucS cleaves both 3' and 5' ssDNA extremities of branched DNA structures and it binds to ssDNA [ , ].

[ "GO:0004519" ]

[ "endonuclease activity" ]

[ "molecular_function" ]

1

[ "HAMAP", "PANTHER", "CDD" ]

[ "MF_00722", "PTHR38814", "cd22341" ]

[ "NucS", "", "NucS-like" ]

[ 4965, 5544, 5703 ]

3

[]

0

[ "2vld", "5gke", "5gkf", "5gkg", "5gkh", "5gki", "5gkj" ]

7

[ "PUB00052724", "PUB00060574" ]

[ "19609302", "22431731" ]

[ "Structure and function of a novel endonuclease acting on branched DNA substrates.", "Modulation of the Pyrococcus abyssi NucS endonuclease activity by replication clamp at functional and structural levels." ]

[ 2009, 2012 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Halogranum tailed virus 1", "metagenomes" ]

[ 637, 5048, 2, 1, 140 ]

5

[]

0

true

Family

Endonuclease NucS

Endonuclease_NucS

4

IPR002794

2,794

Protein of unknown function DUF92, TMEM19

DUF92_TMEM19

Family

7,425

false

Many members of this family have no known function and are predicted to be integral membrane proteins. One member of the family has been characterised as protein PGR (AtPGR). PGR is suggested to be a potential glucose-responsive regulator in carbohydrate metabolism in plants. This entry also includes protein VTE6, whic...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER", "NCBIFAM" ]

[ "PF01940", "PTHR13353", "TIGR00297" ]

[ "DUF92", "", "" ]

[ 7418, 7267, 571 ]

3

[]

0

[]

0

[ "PUB00092523" ]

[ "26452599" ]

[ "Remobilization of Phytol from Chlorophyll Degradation Is Essential for Tocopherol Synthesis and Growth of Arabidopsis." ]

[ 2015 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 746, 1764, 4866, 49 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 9, 5, 3, 5, 4, 1, 7, 7, 24 ]

9

true

Family

Protein of unknown function DUF92, TMEM19

DUF92_TMEM19

4

IPR002795

2,795

S-adenosylmethionine synthetase, archaea

S-AdoMet_synthetase_arc

Family

640

false

A highly diverged class of S-adenosylmethionine synthetases have been identified in the archaea. S-adenosylmethionine is the primary alkylating agent in all known organisms. ATP:L-methionine S-adenosyltransferase (MAT) catalyses the only known biosynthetic route to this central metabolite. Although the amino acid seque...

[ "GO:0004478", "GO:0005524", "GO:0006730" ]

[ "methionine adenosyltransferase activity", "ATP binding", "one-carbon metabolic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "HAMAP" ]

[ "MF_00136" ]

[ "S_AdoMet_synth2" ]

[ 640 ]

1

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "2.5.1.6", "PWY-5041", "PWY-5912", "PWY-6151" ]

[ "EC:2.5.1.6", "METACYC:PWY-5041", "METACYC:PWY-5912", "METACYC:PWY-6151" ]

4

[ "4hpv", "4k0b", "4l2z", "4l4q", "4l7i", "4ws9", "6s81", "6s83", "7p82", "7p83", "7p84", "7p8m" ]

12

[ "PUB00006472" ]

[ "10660563" ]

[ "Identification of a highly diverged class of S-adenosylmethionine synthetases in the archaea." ]

[ 2000 ]

1

[ "IPR027790" ]

[]

1

0

1

[ "Aquifex aeolicus (strain VF5)", "Archaea", "ecological metagenomes" ]

[ 1, 636, 3 ]

3

[]

0

true

Family

S-adenosylmethionine synthetase, archaea

S-AdoMet_synthetase_arc

5

IPR002797

2,797

Polysaccharide biosynthesis protein

Polysacc_synth

Family

44,901

false

Members of this family are integral membrane proteins [ ], and many are implicated in the production of polysaccharide. The family includes RfbX part of the O antigen biosynthesis operon [ ], and SpoVB from Bacillus subtilis ( ), which is involved in spore cortex biosynthesis [ ].

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF01943" ]

[ "Polysacc_synt" ]

[ 44901 ]

1

[ "GP" ]

[ "GenProp0724" ]

[ "GP:GenProp0724" ]

1

[ "9g95", "9g97", "9g9m", "9g9n", "9g9o", "9g9p" ]

6

[ "PUB00005697", "PUB00005717", "PUB00005723" ]

[ "1744050", "8118055", "7517390" ]

[ "Cloning, characterization, and expression of the spoVB gene of Bacillus subtilis.", "Analysis of the Rhizobium meliloti genes exoU, exoV, exoW, exoT, and exoI involved in exopolysaccharide biosynthesis and nodule invasion: exoU and exoW probably encode glucosyltransferases.", "Genetic analysis of the O-specifi...

[ 1991, 1993, 1994 ]

3

[]

[ "IPR024923", "IPR044550" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified Caudoviricetes", "unclassified sequences" ]

[ 1669, 42786, 13, 2, 431 ]

5

[ "Escherichia coli (strain K12)" ]

[ 4 ]

1

true

Family

Polysaccharide biosynthesis protein

Polysacc_synth

9

IPR002798

2,798

Stage II sporulation protein M-like

SpoIIM-like

Family

11,265

false

This entry represents a group of predicted integral membrane proteins, including Stage II sporulation protein M (spoIIM) from Bacillus subtilis ( ). SpoIIM is on e of four stage II sporulation proteins that is necessary for the forespore inside the mother-cell to be properly internalised through the breakdown of peptid...

[]

0

[ "PFAM" ]

[ "PF01944" ]

[ "SpoIIM" ]

[ 11265 ]

1

[]

0

[]

0

[ "PUB00075416" ]

[ "7376078" ]

[ "Amputation level following unsuccessful distal limb salvage operations." ]

[ 1980 ]

1

[]

[ "IPR014196" ]

0

1

0

[ "Archaea", "Bacteria", "Opisthokonta", "metagenomes" ]

[ 871, 10327, 3, 64 ]

4

[]

0

true

Family

Stage II sporulation protein M-like

SpoIIM-like

4

IPR002801

2,801

Aspartate transcarbamylase regulatory subunit

Asp_carbamoylTrfase_reg

Family

4,682

false

Aspartate carbamoyltransferase (aspartate transcarbamylase, ATCase) is an allosteric enzyme that plays a central role in the regulation of the pyrimidine pathway in bacteria. The holoenzyme is a dodecamer composed of six catalytic chains, each with an active site, and six regulatory chains lacking catalytic activity [ ...

[ "GO:0006207", "GO:0009347" ]

[ "'de novo' pyrimidine nucleobase biosynthetic process", "aspartate carbamoyltransferase complex" ]

[ "biological_process", "cellular_component" ]

2

[ "HAMAP", "PANTHER", "NCBIFAM" ]

[ "MF_00002", "PTHR35805", "TIGR00240" ]

[ "Asp_carb_tr_reg", "", "ATCase_reg" ]

[ 3330, 4681, 3249 ]

3

[ "GP", "GP", "GP" ]

[ "GenProp0187", "GenProp1172", "GenProp1427" ]

[ "GP:GenProp0187", "GP:GenProp1172", "GP:GenProp1427" ]

3

[ "1acm", "1at1", "1d09", "1ezz", "1f1b", "1i5o", "1nbe", "1pg5", "1q95", "1r0b", "1r0c", "1raa", "1rab", "1rac", "1rad", "1rae", "1raf", "1rag", "1rah", "1rai", "1sku", "1tth", "1tu0", "1tug", "1xjw", "1za1", "1za2", "2a0f", "2air", "2at1", "2atc", "2be7"...

66

[ "PUB00006327", "PUB00006462", "PUB00006470", "PUB00014302" ]

[ "7791626", "10600394", "10651286", "11323717" ]

[ "Cooperativity in enzyme function: equilibrium and kinetic aspects.", "Intramolecular signal transmission in enterobacterial aspartate transcarbamylases II. Engineering co-operativity and allosteric regulation in the aspartate transcarbamylase of Erwinia herbicola.", "Insights into the mechanisms of catalysis a...

[ 1995, 1999, 1999, 2001 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 859, 3661, 56, 106 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Aspartate transcarbamylase regulatory subunit

Asp_carbamoylTrfase_reg

1

IPR002802

2,802

Endonuclease dU

Endo_dU

Family

1,082

false

This entry includes Endonuclease dU (Endo_dU) from Archaeoglobus fulgidus (AF_1433, ) and similar prokaryotic. Sequence and structure analysis to identify RNase H-like superfamily members, has clustered this family in endonuclease Clade V, thus suggesting endonuclease activity of these proteins [ ]. Endo_dU, which clea...

[]

0

[ "HAMAP", "PFAM", "PIRSF", "PANTHER" ]

[ "MF_00582", "PF01949", "PIRSF006380", "PTHR39518" ]

[ "UPF0215", "Endo_dU", "UCP006380", "" ]

[ 989, 1082, 796, 1072 ]

4

[]

0

[ "2qh9" ]

1

[ "PUB00098031", "PUB00160071" ]

[ "24464998", "39426726" ]

[ "The RNase H-like superfamily: new members, comparative structural analysis and evolutionary classification.", "DUF99 family proteins are novel endonucleases that cleave deoxyuridine on DNA substrates." ]

[ 2014, 2024 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Rhodymeniophycidae", "ecological metagenomes" ]

[ 805, 244, 2, 31 ]

4

[]

0

true

Family

Endonuclease dU

Endo_dU

6

IPR002803

2,803

Fructose-1,6-bisphosphatase, class V

FBPase_V

Family

956

false

Fructose-1,6-bisphophatase (FBPase) catalyses the hydrolysis of D-fructose-1,6-bisphosphate (FBP) to D-fructose-6-phopshate (F6P) and orthophosphate, and is a key enzyme in gluconeogenesis [ ]. Three different groups of FBPases have been identified in eukaryotes and bacteria (FBPase I-III) [ ]. None of these groups hav...

[]

0

[ "HAMAP", "NCBIFAM", "PFAM", "PIRSF", "PANTHER" ]

[ "MF_02067", "NF041126", "PF01950", "PIRSF015647", "PTHR38341" ]

[ "FBP_aldolase_phosphatase", "FBP_aldo_phos", "FBPase_3", "FBPtase_archl", "" ]

[ 779, 690, 956, 764, 946 ]

5

[ "EC", "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "3.1.3.11", "4.1.2.13", "GenProp0120", "PWY-1042", "PWY-1861", "PWY-5484", "PWY-6142", "PWY-7385", "PWY-8178", "PWY-8404" ]

[ "EC:3.1.3.11", "EC:4.1.2.13", "GP:GenProp0120", "METACYC:PWY-1042", "METACYC:PWY-1861", "METACYC:PWY-5484", "METACYC:PWY-6142", "METACYC:PWY-7385", "METACYC:PWY-8178", "METACYC:PWY-8404" ]

10

[ "1umg", "3r1m", "3t2b", "3t2c", "3t2d", "3t2e", "3t2f", "3t2g" ]

8

[ "PUB00016008", "PUB00020983", "PUB00020984", "PUB00020985", "PUB00020986" ]

[ "10986273", "9452458", "11062561", "12065581", "15274916" ]

[ "Purification and characterization of glpX-encoded fructose 1, 6-bisphosphatase, a new enzyme of the glycerol 3-phosphate regulon of Escherichia coli.", "In vitro reconstitution of glucose-induced targeting of fructose-1, 6-bisphosphatase into the vacuole in semi-intact yeast cells.", "MJ0109 is an enzyme that ...

[ 2000, 1998, 2000, 2002, 2004 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Geodia barretti", "unclassified sequences" ]

[ 449, 427, 4, 76 ]

4

[]

0

true

Family

Fructose-1,6-bisphosphatase, class V

FBPase_V

9

IPR002805

2,805

Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase, archaeal type

Nict_dMeBzImd_PRibTrfase_arc

Family

1,258

false

This entry represents the archaeal-type nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferases. Nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole (DMB) phosphoribosyltransferase (CobT) plays a central role in the synthesis of alpha-ribazole-5'-phosphate, an intermediate for the lower ligand of ...

[]

0

[ "HAMAP", "PANTHER", "NCBIFAM" ]

[ "MF_01086", "PTHR38811", "TIGR00303" ]

[ "UPF0284", "", "" ]

[ 1176, 1258, 923 ]

3

[]

0

[ "3l0z", "3u4g", "6pt8", "6ptf", "6pu6" ]

5

[ "PUB00009745", "PUB00014667", "PUB00014670", "PUB00014672", "PUB00015874", "PUB00015996" ]

[ "7592411", "12196148", "8550510", "11153269", "12101181", "8206834" ]

[ "The cobalamin (coenzyme B12) biosynthetic genes of Escherichia coli.", "Biosynthesis of cobalamin (vitamin B(12)).", "Salmonella typhimurium cobalamin (vitamin B12) biosynthetic genes: functional studies in S. typhimurium and Escherichia coli.", "Multiple biosynthetic pathways for vitamin B12: variations on ...

[ 1995, 2002, 1996, 2001, 2002, 1994 ]

6

[ "IPR003200" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Geodia barretti", "ecological metagenomes" ]

[ 756, 472, 1, 29 ]

4

[]

0

true

Family

Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase, archaeal type

Nict_dMeBzImd_PRibTrfase_arc

9

IPR002808

2,808

Adenosylcobinamide amidohydrolase, CbiZ

AdoCbi_amidolase

Family

3,295

false

This archaeal and prokaryotic protein family includes CbiZ, which converts adenosylcobinamide (AdoCbi) to adenosylcobyric acid (AdoCby), an intermediate of the de novo coenzyme B12 biosynthetic route [ ].

[]

0

[ "PFAM" ]

[ "PF01955" ]

[ "CbiZ" ]

[ 3295 ]

1

[]

0

[]

0

[ "PUB00019258" ]

[ "14990804" ]

[ "CbiZ, an amidohydrolase enzyme required for salvaging the coenzyme B12 precursor cobinamide in archaea." ]

[ 2004 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 655, 2588, 20, 32 ]

4

[]

0

true

Family

Adenosylcobinamide amidohydrolase, CbiZ

AdoCbi_amidolase

4

IPR002809

2,809

Integral membrane protein EMC3/TMCO1-like

EMC3/TMCO1

Family

8,457

false

This entry represents a group of eukaryotic and archaeal proteins from the Oxa1 superfamily which includes a group of proteins that function in different contexts as transmembrane domains (TMD) insertases and/or as intramembrane chaperones to facilitate membrane protein folding and assembly [ , ]. Eukaryotic members in...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "SMART" ]

[ "PF01956", "SM01415" ]

[ "EMC3_TMCO1", "DUF106" ]

[ 8443, 8015 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-8980692", "R-HSA-8980692", "R-MMU-8980692", "R-RNO-8980692" ]

[ "REACTOME:R-BTA-8980692", "REACTOME:R-HSA-8980692", "REACTOME:R-MMU-8980692", "REACTOME:R-RNO-8980692" ]

4

[ "5c8j", "6w6l", "6wb9", "6ww7", "6z3w", "7ado", "7adp", "7kra", "7ktx", "7tut", "8eoi", "8j0n", "8j0o", "8s9s", "9c7v" ]

15

[ "PUB00061987", "PUB00081416", "PUB00086930", "PUB00097241", "PUB00103609", "PUB00151274", "PUB00151275" ]

[ "19325107", "27212239", "26256539", "32820719", "36261522", "29281821", "35927240" ]

[ "Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum.", "TMCO1 Is an ER Ca(2+) Load-Activated Ca(2+) Channel.", "A YidC-like Protein in the Archaeal Plasma Membrane.", "An ER translocon for multi-pass membrane protein biogenesis.", "Substrate-driven assembly of ...

[ 2009, 2016, 2015, 2020, 2022, 2017, 2022 ]

7

[]

[ "IPR008559", "IPR008568", "IPR038978" ]

0

3

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 892, 4, 7516, 45 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 9, 2, 4, 3, 11, 4, 1, 5, 9, 1, 1, 9 ]

12

true

Family

Integral membrane protein EMC3/TMCO1-like

EMC3/TMCO1

1

IPR002811

2,811

Aspartate dehydrogenase

Asp_DH

Domain

4,259

false

This group contains aspartate dehydrogenases that belong to a unique class of amino acid dehydrogenases. The structure of Thermotoga maritima TM1643 has been found to contain an N-terminal Rossmann fold domain (which binds the NAD(P) + cofactor) and a C-terminal α/β domain [ ]. This suggested that TM1643 may be a dehyd...

[ "GO:0033735", "GO:0009435" ]

[ "aspartate dehydrogenase [NAD(P)+] activity", "NAD+ biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF01958" ]

[ "Asp_DH_C" ]

[ 4259 ]

1

[ "EC" ]

[ "1.4.1.21" ]

[ "EC:1.4.1.21" ]

1

[ "1h2h", "1j5p", "2dc1" ]

3

[ "PUB00014412" ]

[ "12496312" ]

[ "Aspartate dehydrogenase, a novel enzyme identified from structural and functional studies of TM1643." ]

[ 2003 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 368, 2891, 945, 55 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 5, 2, 3, 4 ]

5

true

Domain

Aspartate dehydrogenase

Asp_DH

1

IPR002813

2,813

Arginine biosynthesis protein ArgJ

Arg_biosynth_ArgJ

Family

20,574

false

ArgJ (also known as Ornithine acetyltransferase/OAT) is a bifunctional protein that catalyses the first and fifth steps in arginine biosynthesis [ ], coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in the arginine biosynthetic pathway. The structure ...

[ "GO:0004358", "GO:0006526" ]

[ "L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor", "L-arginine biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PFAM", "PANTHER", "NCBIFAM", "CDD" ]

[ "MF_01106", "PF01960", "PTHR23100", "TIGR00120", "cd02152" ]

[ "ArgJ", "ArgJ", "", "ArgJ", "OAT" ]

[ 20085, 20527, 20478, 19385, 19507 ]

5

[ "EC", "EC", "GP", "METACYC" ]

[ "2.3.1.1", "2.3.1.35", "GenProp0118", "PWY-5154" ]

[ "EC:2.3.1.1", "EC:2.3.1.35", "GP:GenProp0118", "METACYC:PWY-5154" ]

4

[ "1vra", "1vz6", "1vz7", "1vz8", "2v4i", "2vzk", "2yep", "3it4", "3it6" ]

9

[ "PUB00005708", "PUB00014499", "PUB00037999", "PUB00079801", "PUB00079802", "PUB00079803" ]

[ "8473852", "12633501", "15352873", "15375131", "4365537", "15937278" ]

[ "Primary structure, partial purification and regulation of key enzymes of the acetyl cycle of arginine biosynthesis in Bacillus stearothermophilus: dual function of ornithine acetyltransferase.", "N-acetylglutamate and its changing role through evolution.", "X-ray crystal structure of ornithine acetyltransferas...

[ 1993, 2003, 2005, 2004, 1974, 2005 ]

6

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 267, 16893, 2905, 509 ]

4

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 4, 1, 2, 1, 1, 9 ]

6

true

Family

Arginine biosynthesis protein ArgJ

Arg_biosynth_ArgJ

4

IPR002815

2,815

Spo11/DNA topoisomerase VI subunit A

Spo11/TopoVI_A

Family

7,555

false

This entry represents Spo11, a meiotic recombination protein found in eukaryotes, and subunit A of topoisomerase VI, a type IIB topoisomerase found predominantly in archaea [ , , , ]. These two types of proteins share structural homology. DNA topoisomerases regulate the number of topological links between two DNA stran...

[ "GO:0003677", "GO:0003918", "GO:0005694" ]

[ "DNA binding", "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity", "chromosome" ]

[ "molecular_function", "molecular_function", "cellular_component" ]

3

[ "PRINTS", "PANTHER" ]

[ "PR01550", "PTHR10848" ]

[ "TOP6AFAMILY", "" ]

[ 6754, 7487 ]

2

[ "EC", "REACTOME" ]

[ "5.6.2.2", "R-HSA-912446" ]

[ "EC:5.6.2.2", "REACTOME:R-HSA-912446" ]

2

[ "1d3y", "2q2e", "2zbk", "8urq", "8uru" ]

5

[ "PUB00007202", "PUB00020793", "PUB00020804", "PUB00020805", "PUB00075470", "PUB00083725" ]

[ "10545127", "12596227", "12618182", "11805049", "22346761", "26917763" ]

[ "Structure and function of an archaeal topoisomerase VI subunit with homology to the meiotic recombination factor Spo11.", "Phylogenomics of type II DNA topoisomerases.", "Emerging roles for plant topoisomerase VI.", "Functional interactions between SPO11 and REC102 during initiation of meiotic recombination ...

[ 1999, 2003, 2003, 2002, 2012, 2016 ]

6

[]

[ "IPR004085", "IPR013048" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 989, 102, 6410, 54 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 14, 2, 4, 9, 4, 2, 1, 16, 5, 1, 1, 22 ]

12

true

Family

Spo11/DNA topoisomerase VI subunit A

Spo11/TopoVI_A

7

IPR002816

2,816

TraB/PrgY/GumN family

TraB/PrgY/GumN_fam

Family

18,432

false

This entry includes Tiki1/2 from humans, TraB/PrgY from the gut flora Enterococcus faecalis and gumN from the plant pathogen Xanthomonas. Tiki1 is homologous to TraB/PrgY. They have a pair of widely spaced GX2H motifs and a conserved glutamate. From the structural study, this group of proteins have been identified as a...

[]

0

[ "PFAM" ]

[ "PF01963" ]

[ "TraB_PrgY_gumN" ]

[ 18432 ]

1

[]

0

[]

0

[ "PUB00091071", "PUB00095434" ]

[ "22726442", "23673329" ]

[ "Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation.", "The TIKI/TraB/PrgY family: a common protease fold for cell signaling from bacteria to metazoa?" ]

[ 2012, 2013 ]

2

[]

[ "IPR040230", "IPR046345", "IPR047111" ]

0

3

0

[ "Archaea", "Bacteria", "Catovirus CTV1", "Eukaryota", "unclassified sequences" ]

[ 738, 10874, 1, 6677, 142 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 17, 3, 6, 1, 1, 6, 5, 6, 12, 10 ]

10

true

Family

TraB/PrgY/GumN family

TraB/PrgY/GumN_fam

8

IPR002817

2,817

Phosphomethylpyrimidine synthase ThiC/5-hydroxybenzimidazole synthase BzaA/B

ThiC/BzaA/B

Family

19,513

false

This entry includes phosphomethylpyrimidine synthases, including thiC from prokaryotes and AtTHIC from Arabidopsis. thiC is found within the thiamin biosynthesis operon and is involved in thiamin biosynthesis [ ]. ThiC catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from amin...

[ "GO:0051536", "GO:0009228" ]

[ "iron-sulfur cluster binding", "thiamine biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER", "SFLD", "NCBIFAM" ]

[ "PF01964", "PTHR30557", "SFLDF00407", "TIGR00190" ]

[ "ThiC_Rad_SAM", "", "phosphomethylpyrimidine_syntha", "thiC" ]

[ 19414, 19467, 18506, 18588 ]

4

[ "EC", "GP", "GP", "METACYC" ]

[ "4.1.99.17", "GenProp0253", "GenProp1590", "PWY-6890" ]

[ "EC:4.1.99.17", "GP:GenProp0253", "GP:GenProp1590", "METACYC:PWY-6890" ]

4

[ "3epm", "3epn", "3epo", "4n7q", "4s25", "4s26", "4s27", "4s28", "4s29", "4s2a" ]

10

[ "PUB00005854", "PUB00051760", "PUB00074045", "PUB00086657", "PUB00087083" ]

[ "10382260", "18953358", "18332905", "26246619", "15326535" ]

[ "Thiamin biosynthesis in prokaryotes.", "Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily.", "AtTHIC, a gene involved in thiamine biosynthesis in Arabidopsis thaliana.", "Anaerobic biosynthesis of the lower ligand of vitamin B12.", "Biosynthesis of the thiamin p...

[ 1999, 2008, 2008, 2015, 2004 ]

5

[]

[ "IPR037509" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 904, 17374, 883, 352 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 1, 6, 5 ]

4

true

Family

Phosphomethylpyrimidine synthase ThiC/5-hydroxybenzimidazole synthase BzaA/B

ThiC/BzaA/B

7

IPR002818

2,818

DJ-1/PfpI

Domain

125,097

false

The domain is found in intracellular cysteine peptidase PfpI [ ] and other members of the DJ-1/ThiJ/PfpI superfamily [ ]. Some of these have been characterised: Pyrococcus horikoshii PH1704, which has both aminopeptidase and endopeptidase activity [ ]. Arabidopsis thaliana DJ1D, which has glyoxalase I activity [ ]. Can...

[]

0

[ "PFAM" ]

[ "PF01965" ]

[ "DJ-1_PfpI" ]

[ 125097 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-3899300", "R-BTA-9646399", "R-CEL-3899300", "R-CEL-9646399", "R-DME-9646399", "R-DRE-9646399", "R-HSA-3899300", "R-HSA-9613829", "R-HSA-9615710", "R-HSA-9646399", "R-MMU-3899300", "R-MMU-9646399", "R-RNO-3899300", "R-RNO-9646399", "R-SPO-3899300", "R-SPO-9646399" ]

[ "REACTOME:R-BTA-3899300", "REACTOME:R-BTA-9646399", "REACTOME:R-CEL-3899300", "REACTOME:R-CEL-9646399", "REACTOME:R-DME-9646399", "REACTOME:R-DRE-9646399", "REACTOME:R-HSA-3899300", "REACTOME:R-HSA-9613829", "REACTOME:R-HSA-9615710", "REACTOME:R-HSA-9646399", "REACTOME:R-MMU-3899300", "REACTOM...

16

[ "1g2i", "1j42", "1oi4", "1p5f", "1pdv", "1pdw", "1pe0", "1q2u", "1qvv", "1qvw", "1qvz", "1soa", "1sy7", "1u9c", "1ucf", "2ab0", "2fex", "2or3", "2r1t", "2r1u", "2r1v", "2rk3", "2rk4", "2rk6", "2vrn", "3b36", "3b38", "3b3a", "3bhn", "3bwe", "3cne", "3cy6"...

198

[ "PUB00005755", "PUB00030815", "PUB00060672", "PUB00078033", "PUB00078034", "PUB00078035" ]

[ "8626329", "14745011", "19406895", "25192005", "23651081", "24302734" ]

[ "Sequence, expression in Escherichia coli, and analysis of the gene encoding a novel intracellular protease (PfpI) from the hyperthermophilic archaeon Pyrococcus furiosus.", "The 1.8-A resolution crystal structure of YDR533Cp from Saccharomyces cerevisiae: a member of the DJ-1/ThiJ/PfpI superfamily.", "Identifi...

[ 1996, 2004, 2009, 2014, 2013, 2014 ]

6

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Microviridae sp. ctNWS1", "unclassified sequences" ]

[ 1521, 107648, 15352, 1, 575 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 30, 2, 2, 3, 2, 4, 6, 4, 25, 6, 1, 6, 28 ]

13

true

Domain

DJ-1/PfpI

5

IPR002820

2,820

Molybdopterin cofactor biosynthesis C (MoaC) domain

Mopterin_CF_biosynth-C_dom

Domain

24,339

false

The majority of molybdenum-containing enzymes utilise a molybdenum cofactor (MoCF or Moco) consisting of a Mo atom coordinated via a cis-dithiolene moiety to molybdopterin (MPT). MoCF is ubiquitous in nature, and the pathway for MoCF biosynthesis is conserved in all three domains of life. MoCF-containing enzymes functi...

[ "GO:0006777" ]

[ "Mo-molybdopterin cofactor biosynthetic process" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF01967" ]

[ "MoaC" ]

[ 24339 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "4.6.1.17", "PWY-6823", "R-BTA-947581", "R-DDI-947581", "R-DME-947581", "R-HSA-947581", "R-MMU-947581" ]

[ "EC:4.6.1.17", "METACYC:PWY-6823", "REACTOME:R-BTA-947581", "REACTOME:R-DDI-947581", "REACTOME:R-DME-947581", "REACTOME:R-HSA-947581", "REACTOME:R-MMU-947581" ]

7

[ "1ekr", "1eks", "2eey", "2ekn", "2ide", "2iih", "2ohd", "3jqj", "3jqk", "3jqm", "4fdf", "4pya", "4pyd" ]

13

[ "PUB00015635", "PUB00015921", "PUB00034757", "PUB00034758", "PUB00034759" ]

[ "12372836", "8528286", "12114025", "17198377", "16784786" ]

[ "In vivo interactions between gene products involved in the final stages of molybdenum cofactor biosynthesis in Escherichia coli.", "Molybdenum co-factor biosynthesis: the Arabidopsis thaliana cDNA cnx1 encodes a multifunctional two-domain protein homologous to a mammalian neuroprotein, the insect protein Cinnamo...

[ 2002, 1995, 2002, 2007, 2006 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 809, 19108, 3981, 441 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 5, 1, 1, 2, 1, 2, 1, 1, 4, 2, 5 ]

11

true

Domain

Molybdopterin cofactor biosynthesis C (MoaC) domain

Mopterin_CF_biosynth-C_dom

1

IPR002821

2,821

Hydantoinase A/oxoprolinase

Hydantoinase_A

Domain

29,387

false

This domain is found in the enzymes hydantoinase A (HyuA) and oxoprolinase ( ). Both enzymes catalyse reactions involving the hydrolysis of 5-membered rings via hydrolysis of their internal imide bonds [ ]. This domain is also found in (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine synthase ...

[ "GO:0016787" ]

[ "hydrolase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF01968" ]

[ "Hydantoinase_A" ]

[ 29387 ]

1

[ "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "GenProp1664", "R-DDI-174403", "R-HSA-174403", "R-HSA-5578998", "R-MMU-174403", "R-RNO-174403", "R-SCE-174403", "R-SPO-174403" ]

[ "GP:GenProp1664", "REACTOME:R-DDI-174403", "REACTOME:R-HSA-174403", "REACTOME:R-HSA-5578998", "REACTOME:R-MMU-174403", "REACTOME:R-RNO-174403", "REACTOME:R-SCE-174403", "REACTOME:R-SPO-174403" ]

8

[ "3c0b", "3cet", "5l9w", "5m45", "5svb", "5svc", "6yra", "9h03" ]

8

[ "PUB00005769", "PUB00019732", "PUB00077118" ]

[ "8943290", "1732229", "26100040" ]

[ "The amino acid sequence of rat kidney 5-oxo-L-prolinase determined by cDNA cloning.", "Cloning and sequencing of the genes involved in the conversion of 5-substituted hydantoins to the corresponding L-amino acids from the native plasmid of Pseudomonas sp. strain NS671.", "Identification of the Final Two Genes ...

[ 1996, 1992, 2015 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1498, 18402, 9012, 475 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 2, 1, 2, 2, 3, 2, 3, 6, 1, 2, 2 ]

12

true

Domain

Hydantoinase A/oxoprolinase

Hydantoinase_A

3

IPR002822

2,822

Nickel insertion protein

Ni_insertion

Family

5,835

false

Members of this family may be involved in the activation of nickel-pincer cofactor-dependent enzymes. LarC from Lactobacillus plantarum is involved, together with LarB and LarE, in the synthesis of the enzyme-bound cofactor of lactate racemase (LarA). Larc C binds Ni2+, and functions in nickel delivery to pyridinium-3,...

[]

0

[ "HAMAP", "PFAM", "PANTHER", "NCBIFAM" ]

[ "MF_01074", "PF01969", "PTHR36566", "TIGR00299" ]

[ "LarC", "Ni_insertion", "", "" ]

[ 3322, 5835, 5720, 3739 ]

4

[]

0

[ "3c19", "6bwo", "6bwq", "6bwr", "6iwj" ]

5

[ "PUB00085157", "PUB00086644" ]

[ "24710389", "27114550" ]

[ "Lactate racemase is a nickel-dependent enzyme activated by a widespread maturation system.", "Nickel-pincer cofactor biosynthesis involves LarB-catalyzed pyridinium carboxylation and LarE-dependent sacrificial sulfur insertion." ]

[ 2014, 2016 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 736, 4695, 186, 218 ]

4

[]

0

true

Family

Nickel insertion protein

Ni_insertion

2

IPR002823

2,823

Protein of unknown function DUF112, transmembrane

DUF112_TM

Domain

23,050

false

This entry represents a domain found in a group of uncharacterised prokaryotic sequences, including 52.8 kDa protein in TAR-I ttuC' 3'region from the common pathogen of grapevine Agrobacterium vitis [ ]. In most members of this group, predicted to be integral membrane proteins, this domain covers the whole length of th...

[]

0

[ "PFAM" ]

[ "PF01970" ]

[ "TctA" ]

[ 23050 ]

1

[]

0

[]

0

[ "PUB00006491", "PUB00158994" ]

[ "8672817", "36823423" ]

[ "Characterization and distribution of tartrate utilization genes in the grapevine pathogen Agrobacterium vitis.", "Random transposon mutagenesis identifies genes essential for transformation in Methanococcus maripaludis." ]

[ 1996, 2023 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Caudovirales sp. ct0jG3", "Eukaryota", "unclassified sequences" ]

[ 885, 21725, 1, 33, 406 ]

5

[]

0

true

Domain

Protein of unknown function DUF112, transmembrane

DUF112_TM

9

IPR002825

2,825

Uncharacterized protein MJ0137-like

MJ0137-like

Family

1,927

false

This family of archaebacterial proteins, ex DUF114, has been found to be a serine proteinase, distantly related to ClpP proteinases that belong to the serine proteinase superfamily. The family belong to MEROPS peptidase family S49; they are mostly uncharacterised peptidases. This family includes Uncharacterized protein...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF01972", "PTHR35984" ]

[ "SDH_protease", "" ]

[ 1760, 1920 ]

2

[]

0

[]

0

[ "PUB00000522", "PUB00003576", "PUB00050721", "PUB00053691" ]

[ "8439290", "7845208", "18421152", "15752073" ]

[ "Evolutionary families of peptidases.", "Families of serine peptidases.", "Novel dimer structure of a membrane-bound protease with a catalytic Ser-Lys dyad and its linkage to stomatin.", "Identification and analysis of a new family of bacterial serine proteinases." ]

[ 1993, 1994, 2008, 2004 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Geodia barretti", "Viruses", "metagenomes" ]

[ 295, 1538, 1, 37, 56 ]

5

[]

0

true

Family

Uncharacterized protein MJ0137-like

MJ0137-like

1

IPR002826

2,826

6-hydroxymethylpterin diphosphokinase MptE-like

MptE-like

Domain

6,502

false

This domain can be found in a group of proteins, including archaeal 6-hydroxymethylpterin diphosphokinase (6-HMDPK), known as MptE, which catalyses the formation of 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) from 6-HMD and ATP [ ]. 6-HMDP is the precursor of the pterin containing moiety of the essential C1-...

[]

0

[ "PFAM" ]

[ "PF01973" ]

[ "MptE-like" ]

[ 6502 ]

1

[]

0

[ "5mu5", "8sbu", "8sd5" ]

3

[ "PUB00061602" ]

[ "22931285" ]

[ "Comparative genomics guided discovery of two missing archaeal enzyme families involved in the biosynthesis of the pterin moiety of methanopterin and tetrahydrofolate." ]

[ 2012 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 833, 5490, 10, 15, 154 ]

5

[]

0

true

Domain

6-hydroxymethylpterin diphosphokinase MptE-like

MptE-like

8

IPR002828

2,828

Survival protein SurE-like phosphatase/nucleotidase

SurE-like_Pase/nucleotidase

Domain

23,822

false

This entry represents a SurE-like structural domain with a 3-layer α/β/α topology that bears some topological similarity to the N-terminal domain of the glutaminase/asparaginase family. This domain is found in the stationary phase survival protein SurE, a metal ion-dependent phosphatase found in eubacteria, archaea and...

[ "GO:0016787" ]

[ "hydrolase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "NCBIFAM" ]

[ "PF01975", "TIGR00087" ]

[ "SurE", "surE" ]

[ 23821, 19283 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "3.1.3.5", "PWY-5381", "PWY-5695", "PWY-6596", "PWY-6606", "PWY-6607", "PWY-6608", "PWY-7185", "PWY-7821" ]

[ "EC:3.1.3.5", "METACYC:PWY-5381", "METACYC:PWY-5695", "METACYC:PWY-6596", "METACYC:PWY-6606", "METACYC:PWY-6607", "METACYC:PWY-6608", "METACYC:PWY-7185", "METACYC:PWY-7821" ]

9

[ "1ilv", "1j9j", "1j9k", "1j9l", "1l5x", "2e69", "2e6b", "2e6c", "2e6e", "2e6g", "2e6h", "2v4n", "2v4o", "2wqk", "3ty2", "4g9o", "4gad", "4ryt", "4ryu", "4xep", "4xer", "4xgb", "4xgp", "4xh8", "4xj7", "4zg5", "5ksq", "5ksr", "5kss", "5kst" ]

30

[ "PUB00015315", "PUB00017354", "PUB00026311", "PUB00042609" ]

[ "11709173", "12595266", "11524683", "17561111" ]

[ "Structure of Thermotoga maritima stationary phase survival protein SurE: a novel acid phosphatase.", "Structure and function of an archaeal homolog of survival protein E (SurEalpha): an acid phosphatase with purine nucleotide specificity.", "Crystal structure and functional analysis of the SurE protein identif...

[ 2001, 2003, 2001, 2007 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified Caudoviricetes", "unclassified sequences" ]

[ 921, 16726, 5762, 3, 410 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Zea mays" ]

[ 13, 1, 1, 7, 1, 27 ]

6

true

Domain

Survival protein SurE-like phosphatase/nucleotidase

SurE-like_Pase/nucleotidase

4

IPR002830

2,830

UbiD decarboxylyase family

UbiD

Family

17,952

false

This family of proteins is found in prokaryotes, archaea and fungi, with two members in Archaeoglobus fulgidus. They are related to UbiD, a 3-octaprenyl-4-hydroxybenzoate carboxy-lyase (also known as polyprenyl p-hydroxybenzoate decarboxylase) from Escherichia coli that is involved in ubiquinone biosynthesis [ ]. The m...

[ "GO:0016831" ]

[ "carboxy-lyase activity" ]

[ "molecular_function" ]

1

[ "PANTHER", "NCBIFAM" ]

[ "PTHR30108", "TIGR00148" ]

[ "", "" ]

[ 17951, 15262 ]

2

[ "EC", "EC", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "4.1.1", "4.1.1.98", "GenProp0136", "GenProp1744", "PWY-5855", "PWY-5856", "PWY-5857", "PWY-6708", "PWY-6978" ]

[ "EC:4.1.1", "EC:4.1.1.98", "GP:GenProp0136", "GP:GenProp1744", "METACYC:PWY-5855", "METACYC:PWY-5856", "METACYC:PWY-5857", "METACYC:PWY-6708", "METACYC:PWY-6978" ]

9

[ "2idb", "4ip2", "4iws", "4s13", "4za4", "4za5", "4za7", "4za8", "4za9", "4zaa", "4zab", "4zac", "4zad", "5m1b", "5m1c", "5m1d", "5m1e", "5ny5", "5o3m", "5o3n", "6da6", "6da7", "6da9", "6ev3", "6ev4", "6ev5", "6ev6", "6ev7", "6ev8", "6ev9", "6eva", "6evb"...

83

[ "PUB00008052", "PUB00077007", "PUB00077009", "PUB00077010", "PUB00077012", "PUB00077013", "PUB00077014", "PUB00098043" ]

[ "11029449", "15979273", "10438791", "7744052", "20471595", "25647642", "17211544", "30224495" ]

[ "Identification of the ubiD gene on the Escherichia coli chromosome.", "Distribution of genes encoding the microbial non-oxidative reversible hydroxyarylic acid decarboxylases/phenol carboxylases.", "Cloning, characterization, and expression of a novel gene encoding a reversible 4-hydroxybenzoate decarboxylase ...

[ 2000, 2005, 1999, 1995, 2010, 2015, 2007, 2018 ]

8

[]

[ "IPR014095", "IPR014096", "IPR022390", "IPR023677", "IPR032902", "IPR032903" ]

0

6

0

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctwzt2", "unclassified sequences" ]

[ 955, 15428, 1183, 1, 385 ]

5

[ "Escherichia coli (strain K12)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1 ]

2

true

Family

UbiD decarboxylyase family

UbiD

6

IPR002831

2,831

Transcription regulator TrmB, N-terminal

Tscrpt_reg_TrmB_N

Domain

12,812

false

This entry represents the N-terminal DNA-binding domain found in HTH-type sugar sensing transcriptional regulator TrmB from the hyperthermophilic archaea Pyrococcus furiosus and similar prokaryotic sequences. This domain contains a winged-helix-turn-helix (wHTH) [ ]. TrmB, is a protein of 38,800 apparent molecular weig...

[]

0

[ "PFAM" ]

[ "PF01978" ]

[ "TrmB" ]

[ 12812 ]

1

[]

0

[ "1sfx", "2d1h", "2lvs", "3qph", "4rs8", "5box", "5bpd", "5bpi", "5bqt", "5k1y", "5k5o", "5k5q", "5k5r", "5kk1", "6cmv" ]

15

[ "PUB00015607", "PUB00060975", "PUB00158905" ]

[ "12426307", "16135241", "23576322" ]

[ "TrmB, a sugar-specific transcriptional regulator of the trehalose/maltose ABC transporter from the hyperthermophilic archaeon Thermococcus litoralis.", "TrmB, a sugar sensing regulator of ABC transporter genes in Pyrococcus furiosus exhibits dual promoter specificity and is controlled by different inducers.", ...

[ 2003, 2005, 2013 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 5956, 6671, 7, 15, 163 ]

5

[]

0

true

Domain

Transcription regulator TrmB, N-terminal

Tscrpt_reg_TrmB_N

6

IPR002833

2,833

Peptidyl-tRNA hydrolase, PTH2

PTH2

Family

11,856

false

Peptidyl-tRNA hydrolases are enzymes that release tRNAs from peptidyl-tRNA during translation [ ].

[ "GO:0004045" ]

[ "peptidyl-tRNA hydrolase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER", "NCBIFAM", "CDD" ]

[ "PF01981", "PTHR12649", "TIGR00283", "cd02430" ]

[ "PTH2", "", "arch_pth2", "PTH2" ]

[ 11846, 7568, 6675, 6039 ]

4

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.1.29", "R-BTA-5689880", "R-CEL-5689880", "R-HSA-5689880", "R-MMU-5689880", "R-SPO-5689880" ]

[ "EC:3.1.1.29", "REACTOME:R-BTA-5689880", "REACTOME:R-CEL-5689880", "REACTOME:R-HSA-5689880", "REACTOME:R-MMU-5689880", "REACTOME:R-SPO-5689880" ]

6

[ "1q7s", "1rlk", "1rzw", "1wn2", "1xty", "2d3k", "2zv3", "3erj" ]

8

[ "PUB00020200" ]

[ "12475929" ]

[ "Orthologs of a novel archaeal and of the bacterial peptidyl-tRNA hydrolase are nonessential in yeast." ]

[ 2002 ]

1

[]

[ "IPR034759", "IPR042237" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 932, 2081, 8625, 147, 71 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 22, 3, 7, 6, 4, 2, 1, 9, 5, 1, 1, 15 ]

12

true

Family

Peptidyl-tRNA hydrolase, PTH2

PTH2

3

IPR002835

2,835

Phosphoenolpyruvate guanylyltransferase CofC

CofC

Family

4,651

false

Coenzyme F420 is a hydride carrier cofactor that plays important roles in primary and secondary metabolism in a range of bacteria and archaea [ ]. This entry represents CofC family, guanylyltransferases involved in coenzyme F420 biosynthesis. CofC has been shown to catalyse the activation of phosphoenolpyruvate (PEP) a...

[ "GO:0043814" ]

[ "phospholactate guanylyltransferase activity" ]

[ "molecular_function" ]

1

[ "HAMAP", "PFAM", "PANTHER", "NCBIFAM" ]

[ "MF_02114", "PF01983", "PTHR40392", "TIGR03552" ]

[ "CofC", "CofC", "", "F420_cofC" ]

[ 3673, 3855, 4598, 4367 ]

4

[ "EC", "GP" ]

[ "2.7.7", "GenProp0791" ]

[ "EC:2.7.7", "GP:GenProp0791" ]

2

[ "2i5e", "6bwg", "6bwh", "7p97" ]

4

[ "PUB00045885", "PUB00093753" ]

[ "18260642", "30952857" ]

[ "Identification and characterization of the 2-phospho-L-lactate guanylyltransferase involved in coenzyme F420 biosynthesis.", "A revised biosynthetic pathway for the cofactor F420 in prokaryotes." ]

[ 2008, 2019 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Opisthokonta", "metagenomes" ]

[ 668, 3821, 4, 158 ]

4

[]

0

true

Family

Phosphoenolpyruvate guanylyltransferase CofC

CofC

2

IPR002836

2,836

PDCD5-like

Family

5,562

false

This protein family is found in archaea and eukaryota. Proteins in this family contain a predicted DNA-binding domain [ ] and may function as DNA-binding proteins. Methanobacterium thermoautotrophicum MTH1615 was predicted to bind DNA based on structural proteomics data, and this was confirmed by the demonstration that...

[ "GO:0003677" ]

[ "DNA binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF01984", "PIRSF015730", "PTHR10840" ]

[ "dsDNA_bind", "TFAR19", "" ]

[ 5553, 4629, 5292 ]

3

[]

0

[ "1eij", "2cru", "2fh0", "2jxn", "2k6b", "6iqc", "6iqo", "6vmt", "8i25", "8i26" ]

10

[ "PUB00006429", "PUB00008047", "PUB00048246" ]

[ "9920759", "11017201", "19358820" ]

[ "TFAR19, a novel apoptosis-related gene cloned from human leukemia cell line TF-1, could enhance apoptosis of some tumor cells induced by growth factor withdrawal.", "Structural proteomics of an archaeon.", "Structure-function correlation of human programmed cell death 5 protein." ]

[ 1999, 2000, 2009 ]

3

[]

[ "IPR022889" ]

0

1

0

[ "Archaea", "Eukaryota", "Geoalkalibacter subterraneus", "ecological metagenomes" ]

[ 974, 4549, 1, 38 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 1, 1, 4, 3, 1, 5, 7, 1, 1, 10 ]

12

true

Family

PDCD5-like

6

IPR002837

2,837

Protein of unknown function DUF123

DUF123

Family

1,403

false

This family includes DUF123 domain-containing protein HQ_2548A and related uncharacterised hypothetical proteins from archaea and their bacterial homologues. These proteins contain a putative GIY-YIG domain that shows sequence homology with bacterial UvrC DNA repair proteins. Meanwhile, all of them share a C-terminal e...

[]

0

[ "PFAM", "PANTHER", "CDD" ]

[ "PF01986", "PTHR37460", "cd10441" ]

[ "DUF123", "", "GIY-YIG_COG1833" ]

[ 1401, 1237, 1322 ]

3

[]

0

[]

0

[ "PUB00044989" ]

[ "16646971" ]

[ "Phylogenomic analysis of the GIY-YIG nuclease superfamily." ]

[ 2006 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Cephalotrichum gorgonifer", "unclassified sequences" ]

[ 711, 634, 1, 57 ]

4

[]

0

true

Family

Protein of unknown function DUF123

DUF123

8

IPR002838

2,838

Mitochondrial biogenesis protein AIM24

AIM24

Family

22,116

false

In eukaryotes, proteins in this family are involved in mitochondrial biogenesis [ ]. Its function in prokaryotes in unknown.

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF01987", "TIGR00266" ]

[ "AIM24", "" ]

[ 22116, 8070 ]

2

[]

0

[ "1pg6", "1yox" ]

2

[ "PUB00057438" ]

[ "19300474" ]

[ "Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis." ]

[ 2009 ]

1

[]

0

null

[ "Archaea", "Aureococcus anophagefferens virus", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 906, 1, 16930, 4131, 148 ]

5

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Zea mays" ]

[ 14, 2, 4, 1, 10 ]

5

true

Family

Mitochondrial biogenesis protein AIM24

AIM24

7

IPR002840

2,840

Phosphomevalonate dehydratase small subunit-like domain

PMDh-S-like_dom

Domain

2,867

false

This entry represents a domain centrally found in Phosphomevalonate dehydratase small subunit from Aeropyrum pernix (PMDh-S) and similar prokaryotic proteins previously annotated as aconitase X subunit 2, the swiveling domain subunit [ ]. PMDh-S is a component of a hydro-lyase that catalyses the dehydration of mevalona...

[]

0

[ "PFAM", "CDD" ]

[ "PF01989", "cd01356" ]

[ "AcnX_swivel_put", "AcnX_swivel" ]

[ 2867, 2054 ]

2

[ "EC" ]

[ "4.2.1.182" ]

[ "EC:4.2.1.182" ]

1

[ "2hi6", "7cnp", "7cnq", "7cnr", "7cns", "7d2r" ]

6

[ "PUB00080857", "PUB00088769", "PUB00098043", "PUB00154970", "PUB00154971" ]

[ "14568143", "27929065", "30224495", "31924615", "36992929" ]

[ "Filling a gap in the central metabolism of archaea: prediction of a novel aconitase by comparative-genomic analysis.", "Functional characterization of aconitase X as a cis-3-hydroxy-L-proline dehydratase.", "Modified mevalonate pathway of the archaeon <i>Aeropyrum pernix</i> proceeds via <i>trans</i>-anhydrome...

[ 2003, 2016, 2018, 2020, 2023 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 496, 1741, 557, 73 ]

4

[]

0

true

Domain

Phosphomevalonate dehydratase small subunit-like domain

PMDh-S-like_dom

8

IPR002842

2,842

V-type ATPase subunit E

ATPase_V1_Esu

Family

9,285

false

This entry represents subunit E from V-ATPases and A-ATPase/synthases. Subunit E appears to form a tight interaction with subunit G, which together may act as stators to prevent certain subunits from rotating with the central rotary element, much in the same way as the F0 complex subunit B does in F-ATPases [ ]. In add...

[ "GO:0046961", "GO:1902600", "GO:0033178" ]

[ "proton-transporting ATPase activity, rotational mechanism", "proton transmembrane transport", "proton-transporting two-sector ATPase complex, catalytic domain" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "PFAM", "PANTHER" ]

[ "MF_00311", "PF01991", "PTHR45715" ]

[ "ATP_synth_E_arch", "vATP-synt_E", "" ]

[ 6393, 9186, 6962 ]

3

[ "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "GenProp0629", "R-BTA-1222556", "R-BTA-77387", "R-BTA-917977", "R-BTA-9639288", "R-BTA-983712", "R-CEL-1222556", "R-CEL-77387", "R-CEL-917977", "R-CEL-9639288", "R-CEL-983712", "R-DDI-1222556", "R-DDI-77387", "R-DDI-917977", "R-DDI-9639288", "R-DME-1222556", "R-DME-77387", "R-DME-9...

[ "GP:GenProp0629", "REACTOME:R-BTA-1222556", "REACTOME:R-BTA-77387", "REACTOME:R-BTA-917977", "REACTOME:R-BTA-9639288", "REACTOME:R-BTA-983712", "REACTOME:R-CEL-1222556", "REACTOME:R-CEL-77387", "REACTOME:R-CEL-917977", "REACTOME:R-CEL-9639288", "REACTOME:R-CEL-983712", "REACTOME:R-DDI-1222556"...

44

[ "2dm9", "2dma", "2kz9", "3j0j", "3j9t", "3j9u", "3j9v", "3k5b", "3lg8", "3v6i", "4dl0", "4dt0", "4efa", "5bw9", "5d80", "5gar", "5gas", "5tsj", "5vox", "5voy", "5voz", "5y5x", "5y5y", "5y5z", "5y60", "6ly9", "6o7v", "6o7w", "6o7x", "6qum", "6r0w", "6r0y"...

117

[ "PUB00007886", "PUB00009752", "PUB00020603", "PUB00020604", "PUB00020609", "PUB00020618", "PUB00020636", "PUB00020637", "PUB00068786", "PUB00068787", "PUB00068788", "PUB00068789", "PUB00099348", "PUB00160299" ]

[ "11533110", "11309608", "15473999", "15078220", "15629643", "15168615", "15292229", "15751969", "20450191", "18937357", "1385979", "9741106", "33065002", "9874757" ]

[ "Structure-function relationships of A-, F- and V-ATPases.", "Resolution of distinct rotational substeps by submillisecond kinetic analysis of F1-ATPase.", "The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ratio.", "Mechanisms of ATPases--...

[ 2001, 2001, 2004, 2004, 2005, 2004, 2004, 2005, 2010, 2008, 1992, 1998, 2020, 1992 ]

14

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 906, 1681, 6592, 106 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 13, 1, 2, 2, 5, 5, 2, 7, 8, 1, 1, 18 ]

12

true

Family

V-type ATPase subunit E

ATPase_V1_Esu

1

IPR002844

2,844

F420-dependent methylenetetrahydromethanopterin dehydrogenase

MTD

Family

258

false

This archaeal enzyme family is involved in formation of methane from carbon dioxide . The enzyme requires coenzyme F420 [ ].

[ "GO:0008901", "GO:0015948" ]

[ "ferredoxin hydrogenase activity", "methanogenesis" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM", "PFAM", "PIRSF" ]

[ "MF_00058", "NF002162", "PF01993", "PIRSF005627" ]

[ "MTD", "PRK00994.1", "MTD", "MTD" ]

[ 231, 248, 258, 214 ]

4

[ "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "1.5.98.1", "GenProp0002", "PWY-5198", "PWY-5209", "PWY-8112", "PWY-8113", "PWY-8305" ]

[ "EC:1.5.98.1", "GP:GenProp0002", "METACYC:PWY-5198", "METACYC:PWY-5209", "METACYC:PWY-8112", "METACYC:PWY-8113", "METACYC:PWY-8305" ]

7

[ "1qv9", "1u6i", "1u6j", "1u6k", "3iqe", "3iqf", "3iqz" ]

7

[ "PUB00005736" ]

[ "7852356" ]

[ "Cloning, sequencing, and transcriptional analysis of the coenzyme F420-dependent methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase gene from Methanobacterium thermoautotrophicum strain Marburg and functional expression in Escherichia coli." ]

[ 1995 ]

1

[]

0

null

[ "Archaea", "ecological metagenomes" ]

[ 242, 16 ]

2

[]

0

true

Family

F420-dependent methylenetetrahydromethanopterin dehydrogenase

MTD

9