interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR002988 | 2,988 | Protein G-related albumin-binding (GA) module | GA_module | Domain | 1,332 | false | false | Protein G-related albumin-binding (GA) modules occur on the surface of numerous Gram-positive bacterial pathogens. Protein G of group C and G Streptococci interacts with the constant region of IgG and with human serum albumin. The GA module is composed of a left-handed three-helix bundle and is found in a range of bact... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01468"
] | [
"GA"
] | [
1332
] | 1 | [] | [] | [] | 0 | [
"2dgj",
"4kjm",
"6gv5"
] | 3 | [
"PUB00003376",
"PUB00031434",
"PUB00035975",
"PUB00035976"
] | [
"9086265",
"15269208",
"16906768",
"7589548"
] | [
"Solution structure of the albumin-binding GA module: a versatile bacterial protein domain.",
"Crystal structure and biological implications of a bacterial albumin binding module in complex with human serum albumin.",
"Structure, dynamics, and stability variation in bacterial albumin binding modules: implicatio... | [
1997,
2004,
2006,
1995
] | 4 | [] | [
"IPR020840"
] | 0 | 1 | 0 | [
"Bacteria",
"Biomphalaria glabrata",
"metagenomes"
] | [
1326,
1,
5
] | 3 | [] | [] | 0 | true | Domain | Protein G-related albumin-binding (GA) module | Protein G-related albumin-binding (GA) module | GA_module | 6 |
IPR002989 | 2,989 | Mycobacterial pentapeptide repeat | Mycobac_pentapep | Repeat | 2,297 | false | false | These repeats are found in many mycobacterial proteins. The repeats are most common in the PPE family of proteins, where they are found in the MPTR (major polymorphic tandem repeat) subfamily. PPE10, one of the members, is important for capsular integrity and virulence, although the function of these repeats is unknown... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01469"
] | [
"Pentapeptide_2"
] | [
2297
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00005053",
"PUB00094585"
] | [
"9655353",
"27280885"
] | [
"Structure and distribution of pentapeptide repeats in bacteria.",
"The ESX-5 System of Pathogenic Mycobacteria Is Involved In Capsule Integrity and Virulence through Its Substrate PPE10."
] | [
1998,
2016
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanosarcina",
"Viruses",
"metagenomes"
] | [
1969,
226,
4,
93,
5
] | 5 | [
"Drosophila melanogaster"
] | [
1
] | 1 | true | Repeat | Mycobacterial pentapeptide repeat | Mycobacterial pentapeptide repeat | Mycobac_pentapep | 9 |
IPR002994 | 2,994 | Surfeit locus 1/Shy1 | Surf1/Shy1 | Family | 20,308 | false | false | This entry includes SURF1 and Shy1 proteins. The surfeit locus 1 gene (SURF1 or surf-1) encodes a conserved protein of about 300 amino-acid residues that seems to be involved in the biogenesis of cytochrome c oxidase [ ]. Vertebrate SURF1 is evolutionary related to yeast protein Shy1, which is a mitochondrial inner mem... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PFAM",
"PROFILE",
"CDD"
] | [
"PF02104",
"PS50895",
"cd06662"
] | [
"SURF1",
"SURF1",
"SURF1"
] | [
20281,
19401,
18825
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC01040",
"R-CEL-9864848",
"R-DME-9864848",
"R-HSA-9864848",
"R-MMU-9864848",
"R-RNO-9864848"
] | [
"PROSITEDOC:PDOC01040",
"REACTOME:R-CEL-9864848",
"REACTOME:R-DME-9864848",
"REACTOME:R-HSA-9864848",
"REACTOME:R-MMU-9864848",
"REACTOME:R-RNO-9864848"
] | 6 | [
"7w5z",
"8b6h",
"8bqs",
"8gym",
"8gzu"
] | 5 | [
"PUB00003909",
"PUB00062910",
"PUB00062911",
"PUB00062912"
] | [
"9843204",
"10746561",
"10647889",
"11782424"
] | [
"SURF1, encoding a factor involved in the biogenesis of cytochrome c oxidase, is mutated in Leigh syndrome.",
"Missense mutations in SURF1 associated with deficient cytochrome c oxidase assembly in Leigh syndrome patients.",
"Two novel mutations of SURF1 in Leigh syndrome with cytochrome c oxidase deficiency.",... | [
1998,
2000,
1999,
2002
] | 4 | [
"IPR045214"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
2,
15203,
4653,
450
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
14,
2,
1,
2,
4,
6,
1,
4,
6,
1,
1,
11
] | 12 | true | Family | Surfeit locus 1/Shy1 | Surfeit locus 1/Shy1 | Surf1/Shy1 | 2 |
IPR002999 | 2,999 | Tudor domain | Tudor | Domain | 55,623 | false | false | The drosophila Tudor protein, the founder of the Tudor domain family, is encoded by a 'posterior group' gene, which when mutated disrupt normal abdominal segmentation and pole cell formation. Another drosophila gene, homeless, is required for RNA localization during oogenesis. The tudor protein contains multiple repeat... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF00567",
"PS50304",
"SM00333"
] | [
"TUDOR",
"TUDOR",
"TUDOR"
] | [
27679,
30708,
48370
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC50304",
"R-BTA-191859",
"R-CEL-983231",
"R-DME-3214847",
"R-DME-6804759",
"R-DME-9772755",
"R-DRE-3214841",
"R-DRE-72163",
"R-DRE-9843940",
"R-DRE-9843970",
"R-HSA-191273",
"R-HSA-191859",
"R-HSA-212300",
"R-HSA-2995383",
"R-HSA-3214815",
"R-HSA-3214841",
"R-HSA-3214842",
"R-H... | [
"PROSITEDOC:PDOC50304",
"REACTOME:R-BTA-191859",
"REACTOME:R-CEL-983231",
"REACTOME:R-DME-3214847",
"REACTOME:R-DME-6804759",
"REACTOME:R-DME-9772755",
"REACTOME:R-DRE-3214841",
"REACTOME:R-DRE-72163",
"REACTOME:R-DRE-9843940",
"REACTOME:R-DRE-9843970",
"REACTOME:R-HSA-191273",
"REACTOME:R-HSA... | 79 | [
"1g5v",
"1mhn",
"2d9t",
"2dig",
"2diq",
"2e5p",
"2e5q",
"2e6n",
"2eqj",
"2eqk",
"2equ",
"2gf7",
"2gfa",
"2hqe",
"2hqx",
"2l8d",
"2ldm",
"2lto",
"2m0o",
"2mam",
"2o4x",
"2qqr",
"2qqs",
"2wac",
"2xdp",
"2xk0",
"3bdl",
"3dlm",
"3fdr",
"3nth",
"3nti",
"3ntk"... | 114 | [
"PUB00005476",
"PUB00018244",
"PUB00092085",
"PUB00092087",
"PUB00096389",
"PUB00096390"
] | [
"9048482",
"11135666",
"15955813",
"21172665",
"26700805",
"23741747"
] | [
"Tudor domains in proteins that interact with RNA.",
"SMN tudor domain structure and its interaction with the Sm proteins.",
"Tudor domains bind symmetrical dimethylated arginines.",
"TDRD3 is an effector molecule for arginine-methylated histone marks.",
"SMN and symmetric arginine dimethylation of RNA poly... | [
1997,
2001,
2005,
2010,
2016,
2012
] | 6 | [] | [
"IPR047367",
"IPR047376",
"IPR047377",
"IPR047378",
"IPR047379",
"IPR047380",
"IPR047383",
"IPR047384",
"IPR047386",
"IPR047390",
"IPR047395",
"IPR047396",
"IPR047444",
"IPR047445",
"IPR047446",
"IPR047447",
"IPR047448",
"IPR047449",
"IPR047450",
"IPR047452",
"IPR047454",
"... | 0 | 30 | 0 | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"metagenomes"
] | [
108,
5,
55507,
3
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (stra... | [
49,
23,
189,
107,
118,
82,
2,
15,
115,
2,
72
] | 11 | true | Domain | Tudor domain | Tudor domain | Tudor | 6 |
IPR003000 | 3,000 | Sirtuin family | Sirtuin | Family | 53,596 | false | false | The sirtuin (also known as Sir2) family is broadly conserved from bacteria to human. Yeast Sir2 (silent mating-type information regulation 2), the founding member, was first isolated as part of the SIR complex required for maintaining a modified chromatin structure at telomeres. Sir2 functions in transcriptional silenc... | [
"GO:0070403"
] | [
"NAD+ binding"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF02146"
] | [
"SIR2"
] | [
53596
] | 1 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.3.1.286",
"PDOC50305",
"R-BTA-2151201",
"R-CEL-204174",
"R-CEL-2151201",
"R-CEL-5693607",
"R-CEL-9617629",
"R-CEL-9856649",
"R-DDI-2151201",
"R-DDI-427359",
"R-DDI-9856649",
"R-DME-204174",
"R-DME-2151201",
"R-DME-2995383",
"R-DME-427359",
"R-DME-9617629",
"R-DME-9841922",
"R-DM... | [
"EC:2.3.1.286",
"PROSITEDOC:PDOC50305",
"REACTOME:R-BTA-2151201",
"REACTOME:R-CEL-204174",
"REACTOME:R-CEL-2151201",
"REACTOME:R-CEL-5693607",
"REACTOME:R-CEL-9617629",
"REACTOME:R-CEL-9856649",
"REACTOME:R-DDI-2151201",
"REACTOME:R-DDI-427359",
"REACTOME:R-DDI-9856649",
"REACTOME:R-DME-204174... | 61 | [
"1ici",
"1j8f",
"1m2g",
"1m2h",
"1m2j",
"1m2k",
"1m2n",
"1ma3",
"1q14",
"1q17",
"1q1a",
"1s5p",
"1s7g",
"1szc",
"1szd",
"1yc2",
"1yc5",
"2b4y",
"2h2d",
"2h2f",
"2h2g",
"2h2h",
"2h2i",
"2h4f",
"2h4h",
"2h4j",
"2h59",
"2hjh",
"2nyr",
"2od2",
"2od7",
"2od9"... | 272 | [
"PUB00005853",
"PUB00006020",
"PUB00018249",
"PUB00018250",
"PUB00018251",
"PUB00021065",
"PUB00060761"
] | [
"10381378",
"7498786",
"11747420",
"11722841",
"11336676",
"15128440",
"10873683"
] | [
"Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity.",
"The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.",
"... | [
1999,
1995,
2001,
2001,
2001,
2004,
2000
] | 7 | [] | [
"IPR017328",
"IPR026587",
"IPR027546",
"IPR028628"
] | 0 | 4 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
498,
24786,
27516,
340,
456
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
9,
5,
30,
11,
1,
49,
29,
7,
5,
33,
5,
3,
15
] | 13 | true | Family | Sirtuin family | Sirtuin family | Sirtuin | 2 |
IPR003004 | 3,004 | GspF/PilC family | GspF/PilC | Family | 32,582 | false | false | GspF is the inner membrane component of the type II secretion system (T2SS). It interacts with GspE, a cytoplasmic hexameric ATPase of the T2SS [ ]. It shows considerable sequence similarity to PilC, which is required for the formation of type IV secretion system pili [ ]. The type II secretion system (T2SS) is one of ... | [] | [] | [] | 0 | [
"PRINTS",
"PANTHER"
] | [
"PR00812",
"PTHR30012"
] | [
"BCTERIALGSPF",
""
] | [
27202,
32517
] | 2 | [] | [] | [] | 0 | [
"2vma",
"2vmb",
"2whn",
"3c1q",
"3jc8",
"3jc9",
"4hhx",
"5nbg"
] | 8 | [
"PUB00051842",
"PUB00093998",
"PUB00094002",
"PUB00094004",
"PUB00094010"
] | [
"19217396",
"30767847",
"28258547",
"22523076",
"17464073"
] | [
"Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody.",
"Architecture, Function, and Substrates of the Type II Secretion System.",
"1H, 15N and 13C resonance assignments and secondary structure of PulG, the major pseudopilin from Klebsiella oxyt... | [
2009,
2019,
2017,
2012,
2007
] | 5 | [] | [
"IPR011850",
"IPR047692"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Plasmid R64",
"Siphoviridae sp. ctePP3",
"unclassified sequences"
] | [
3,
31736,
82,
1,
1,
759
] | 6 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | GspF/PilC family | GspF/PilC family | GspF/PilC | 8 |
IPR003005 | 3,005 | Amphiphysin | Amphiphysin | Family | 7,426 | false | false | Amphiphysins belong to the expanding BAR (Bin-Amphiphysin-Rvsp) family proteins, all members of which share a highly conserved N-terminal BAR domain, which has predicted coiled-coil structures required for amphiphysin dimerisation and plasma membrane interaction [ , ]. Almost all members also share a conserved C-termin... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46514"
] | [
""
] | [
7426
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6798695",
"R-HSA-8856828",
"R-HSA-9673768",
"R-MMU-6798695",
"R-MMU-8856828",
"R-RNO-6798695",
"R-RNO-8856828"
] | [
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-8856828",
"REACTOME:R-HSA-9673768",
"REACTOME:R-MMU-6798695",
"REACTOME:R-MMU-8856828",
"REACTOME:R-RNO-6798695",
"REACTOME:R-RNO-8856828"
] | 7 | [
"1bb9",
"1muz",
"1mv0",
"1mv3",
"1uru",
"2fic",
"3sog",
"4atm",
"4avm",
"4i1q",
"5i22",
"9bqx"
] | 12 | [
"PUB00006087",
"PUB00006137",
"PUB00014927",
"PUB00065067",
"PUB00101548",
"PUB00101549"
] | [
"10559861",
"9720601",
"12047553",
"23285027",
"27179792",
"28893863"
] | [
"Functional partnership between amphiphysin and dynamin in clathrin-mediated endocytosis.",
"The amphiphysin family of proteins and their role in endocytosis at the synapse.",
"Amphiphysins: raising the BAR for synaptic vesicle recycling and membrane dynamics. Bin-Amphiphysin-Rvsp.",
"Bin2 is a membrane sculp... | [
1999,
1998,
2002,
2012,
2016,
2017
] | 6 | [] | [
"IPR003017",
"IPR003023"
] | 0 | 2 | 0 | [
"Eukaryota"
] | [
7426
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
95,
3,
16,
18,
25
] | 6 | true | Family | Amphiphysin | Amphiphysin | Amphiphysin | 7 |
IPR003008 | 3,008 | Tubulin/FtsZ, GTPase domain | Tubulin_FtsZ_GTPase | Domain | 125,097 | false | false | This entry represents a GTPase domain found in all tubulin chains, such as tubulin alpha, beta and gamma chains, plant ARC3 and prokaryotic FtsZ and CetZ proteins [ , ]. These proteins are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ (homologue of eukaryotic tubulin) is the ... | [
"GO:0005525"
] | [
"GTP binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PRINTS",
"SMART"
] | [
"PF00091",
"PR00423",
"SM00864"
] | [
"Tubulin",
"CELLDVISFTSZ",
"Tubulin"
] | [
124030,
33925,
98695
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-114608",
"R-BTA-190840",
"R-BTA-2132295",
"R-BTA-2467813",
"R-BTA-2500257",
"R-BTA-2565942",
"R-BTA-3371497",
"R-BTA-380259",
"R-BTA-380270",
"R-BTA-380284",
"R-BTA-380320",
"R-BTA-5610787",
"R-BTA-5617833",
"R-BTA-5620912",
"R-BTA-5620924",
"R-BTA-5626467",
"R-BTA-5663220",
... | [
"REACTOME:R-BTA-114608",
"REACTOME:R-BTA-190840",
"REACTOME:R-BTA-2132295",
"REACTOME:R-BTA-2467813",
"REACTOME:R-BTA-2500257",
"REACTOME:R-BTA-2565942",
"REACTOME:R-BTA-3371497",
"REACTOME:R-BTA-380259",
"REACTOME:R-BTA-380270",
"REACTOME:R-BTA-380284",
"REACTOME:R-BTA-380320",
"REACTOME:R-BT... | 233 | [
"1ffx",
"1fsz",
"1ia0",
"1jff",
"1ofu",
"1rlu",
"1rq2",
"1rq7",
"1sa0",
"1sa1",
"1tub",
"1tvk",
"1w58",
"1w59",
"1w5a",
"1w5b",
"1w5e",
"1w5f",
"1z2b",
"1z5v",
"1z5w",
"2bto",
"2btq",
"2hxf",
"2hxh",
"2p4n",
"2q1x",
"2q1y",
"2r6r",
"2r75",
"2rhh",
"2rhj"... | 890 | [
"PUB00003961",
"PUB00004272",
"PUB00044363",
"PUB00074278",
"PUB00074279",
"PUB00074280",
"PUB00096948"
] | [
"9628483",
"9428770",
"9144213",
"25533961",
"15356321",
"18764889",
"25339962"
] | [
"Tubulin and FtsZ form a distinct family of GTPases.",
"Crystal structure of the bacterial cell-division protein FtsZ.",
"An essential cell division gene of Drosophila, absent from Saccharomyces, encodes an unusual protein with tubulin-like and myosin-like peptide motifs.",
"CetZ tubulin-like proteins control... | [
1998,
1998,
1997,
2014,
2004,
2008,
2014
] | 7 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
2892,
29215,
92222,
9,
759
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
61,
19,
36,
27,
1,
140,
47,
4,
47,
74,
4,
4,
193
] | 13 | true | Domain | Tubulin/FtsZ, GTPase domain | Tubulin/FtsZ, GTPase domain | Tubulin_FtsZ_GTPase | 4 |
IPR003010 | 3,010 | Carbon-nitrogen hydrolase | C-N_Hydrolase | Domain | 141,933 | false | false | The carbon-nitrogen hydrolase domain is an around 265-residue domain found in numerous enzymes involved in the reduction of organic nitrogen compounds and ammonia production. Based on their sequence similarity and on the reactions they catalyse, these enzymes can be classified into functionally distinct groups includin... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE"
] | [
"PF00795",
"PS50263"
] | [
"CN_hydrolase",
"CN_HYDROLASE"
] | [
140500,
140467
] | 2 | [
"GP",
"GP",
"GP",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"... | [
"GenProp1273",
"GenProp1371",
"GenProp1431",
"PDOC50263",
"R-BTA-196807",
"R-CFA-163125",
"R-CFA-199220",
"R-CFA-6798695",
"R-DDI-196807",
"R-DDI-6798695",
"R-DDI-73621",
"R-DME-196780",
"R-DME-196807",
"R-DRE-6798695",
"R-HSA-163125",
"R-HSA-196780",
"R-HSA-196807",
"R-HSA-199220"... | [
"GP:GenProp1273",
"GP:GenProp1371",
"GP:GenProp1431",
"PROSITEDOC:PDOC50263",
"REACTOME:R-BTA-196807",
"REACTOME:R-CFA-163125",
"REACTOME:R-CFA-199220",
"REACTOME:R-CFA-6798695",
"REACTOME:R-DDI-196807",
"REACTOME:R-DDI-6798695",
"REACTOME:R-DDI-73621",
"REACTOME:R-DME-196780",
"REACTOME:R-D... | 37 | [
"1ems",
"1erz",
"1f89",
"1fo6",
"1j31",
"1uf4",
"1uf5",
"1uf7",
"1uf8",
"2dyu",
"2dyv",
"2e11",
"2e2k",
"2e2l",
"2ggk",
"2ggl",
"2plq",
"2uxy",
"2vhh",
"2vhi",
"2w1v",
"3dla",
"3hkx",
"3ilv",
"3ivz",
"3iw3",
"3ki8",
"3klc",
"3n05",
"3p8k",
"3sdb",
"3seq"... | 125 | [
"PUB00005733",
"PUB00018231",
"PUB00070122",
"PUB00070124"
] | [
"7987228",
"12054553",
"12898714",
"12771147"
] | [
"A new family of carbon-nitrogen hydrolases.",
"A novel photoprotein from oceanic squid (Symplectoteuthis oualaniensis) with sequence similarity to mammalian carbon-nitrogen hydrolase domains.",
"Saccharomyces cerevisiae QNS1 codes for NAD(+) synthetase that is functionally conserved in mammals.",
"Eukaryotic... | [
1994,
2002,
2003,
2003
] | 4 | [] | [
"IPR044083",
"IPR045254"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1513,
103585,
34452,
10,
2373
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
47,
5,
10,
12,
4,
41,
20,
9,
17,
39,
6,
5,
60
] | 13 | true | Domain | Carbon-nitrogen hydrolase | Carbon-nitrogen hydrolase | C-N_Hydrolase | 4 |
IPR003011 | 3,011 | Cell cycle checkpoint protein, Rad1 | Cell_cycle_checkpoint_Rad1 | Family | 1,811 | false | false | Rad1 is a component of the 9-1-1 cell-cycle checkpoint response complex, which plays a role in checkpoint activation that permits DNA-repair pathways to prevent cell cycle progression in response to DNA damage and replication stress [ , ]. The 9-1-1 complex is recruited to DNA lesions upon damage by the Rad17 (Rad24 in... | [
"GO:0000077",
"GO:0005634"
] | [
"DNA damage checkpoint signaling",
"nucleus"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01246"
] | [
"RAD1REPAIR"
] | [
1811
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-176187",
"R-CEL-5693607",
"R-DME-176187",
"R-DME-5693607",
"R-DME-6804756",
"R-DME-69473",
"R-HSA-176187",
"R-HSA-5685938",
"R-HSA-5693607",
"R-HSA-5693616",
"R-HSA-6804756",
"R-HSA-69473",
"R-HSA-9709570",
"R-MMU-176187",
"R-MMU-5685938",
"R-MMU-5693607",
"R-MMU-6804756",
"... | [
"REACTOME:R-CEL-176187",
"REACTOME:R-CEL-5693607",
"REACTOME:R-DME-176187",
"REACTOME:R-DME-5693607",
"REACTOME:R-DME-6804756",
"REACTOME:R-DME-69473",
"REACTOME:R-HSA-176187",
"REACTOME:R-HSA-5685938",
"REACTOME:R-HSA-5693607",
"REACTOME:R-HSA-5693616",
"REACTOME:R-HSA-6804756",
"REACTOME:R-H... | 19 | [
"3a1j",
"3g65",
"3ggr",
"6j8y",
"7z6h",
"8gnn",
"8wu8"
] | 7 | [
"PUB00060228",
"PUB00062235",
"PUB00062241",
"PUB00062256",
"PUB00086417",
"PUB00086418",
"PUB00086419"
] | [
"9311982",
"9660799",
"21659603",
"21978893",
"10882129",
"10646593",
"16951081"
] | [
"The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast.",
"A human homologue of the Schizosaccharomyces pombe rad1+ checkpoint gene encodes an exonuclease.",
"A DNA damage response screen identifies RHINO, a 9-1-1 and To... | [
1997,
1998,
2011,
2011,
2000,
2000,
2006
] | 7 | [
"IPR003021"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
1811
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1,
1,
3,
2,
1
] | 7 | true | Family | Cell cycle checkpoint protein, Rad1 | Cell cycle checkpoint protein, Rad1 | Cell_cycle_checkpoint_Rad1 | 8 |
IPR003013 | 3,013 | Erythropoietin | Erythroptn | Family | 704 | false | false | null | [
"GO:0005128",
"GO:0005576"
] | [
"erythropoietin receptor binding",
"extracellular region"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PIRSF",
"PRINTS",
"PANTHER"
] | [
"PIRSF001951",
"PR00272",
"PTHR10370"
] | [
"EPO",
"ERYTHROPTN",
""
] | [
440,
667,
685
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-9027276",
"R-BTA-9027284",
"R-HSA-1234158",
"R-HSA-9006335",
"R-HSA-9027276",
"R-HSA-9027277",
"R-HSA-9027283",
"R-HSA-9027284",
"R-MMU-9027276",
"R-MMU-9027284",
"R-RNO-9027276",
"R-RNO-9027284",
"R-SSC-9027276",
"R-SSC-9027284"
] | [
"REACTOME:R-BTA-9027276",
"REACTOME:R-BTA-9027284",
"REACTOME:R-HSA-1234158",
"REACTOME:R-HSA-9006335",
"REACTOME:R-HSA-9027276",
"REACTOME:R-HSA-9027277",
"REACTOME:R-HSA-9027283",
"REACTOME:R-HSA-9027284",
"REACTOME:R-MMU-9027276",
"REACTOME:R-MMU-9027284",
"REACTOME:R-RNO-9027276",
"REACTOM... | 14 | [
"1buy",
"1cn4",
"1eer"
] | 3 | [
"PUB00000639",
"PUB00001756",
"PUB00002479",
"PUB00003648"
] | [
"1420369",
"2877922",
"3346214",
"3773894"
] | [
"Nucleotide sequence of rat erythropoietin.",
"Monkey erythropoietin gene: cloning, expression and comparison with the human erythropoietin gene.",
"Comparative study of the asparagine-linked sugar chains of human erythropoietins purified from urine and the culture medium of recombinant Chinese hamster ovary ce... | [
1992,
1986,
1988,
1986
] | 4 | [
"IPR001323"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
704
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
5,
3,
2
] | 4 | true | Family | Erythropoietin | Erythropoietin | Erythroptn | 6 |
IPR003016 | 3,016 | 2-oxo acid dehydrogenase, lipoyl-binding site | 2-oxoA_DH_lipoyl-BS | Binding_site | 100,173 | false | false | The 2-oxo acid dehydrogenase multienzyme complexes [ ] from bacterial and eukaryotic sources catalyse the oxidative decarboxylation of 2-oxo acids to the corresponding acyl-CoA. These include: Pyruvate dehydrogenase complex (PDC). 2-oxoglutarate dehydrogenase complex (OGDC). Branched-chain 2-oxo acid dehydrogenase comp... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS00189"
] | [
"LIPOYL"
] | [
100173
] | 1 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00168",
"R-BTA-204174",
"R-BTA-5362517",
"R-BTA-6783984",
"R-BTA-70895",
"R-BTA-9013407",
"R-BTA-9837999",
"R-BTA-9857492",
"R-BTA-9859138",
"R-BTA-9861559",
"R-CEL-204174",
"R-CEL-5362517",
"R-CEL-9013407",
"R-CEL-9837999",
"R-CEL-9857492",
"R-CEL-9859138",
"R-CEL-9861559",
"... | [
"PROSITEDOC:PDOC00168",
"REACTOME:R-BTA-204174",
"REACTOME:R-BTA-5362517",
"REACTOME:R-BTA-6783984",
"REACTOME:R-BTA-70895",
"REACTOME:R-BTA-9013407",
"REACTOME:R-BTA-9837999",
"REACTOME:R-BTA-9857492",
"REACTOME:R-BTA-9859138",
"REACTOME:R-BTA-9861559",
"REACTOME:R-CEL-204174",
"REACTOME:R-CE... | 70 | [
"1dxm",
"1fyc",
"1ghj",
"1ghk",
"1gjx",
"1hpc",
"1htp",
"1iyu",
"1iyv",
"1k8m",
"1k8o",
"1lab",
"1lac",
"1onl",
"1pmr",
"1qjo",
"1y8n",
"1y8o",
"1y8p",
"1zko",
"1zy8",
"2dnc",
"2dne",
"2edg",
"2k7v",
"2ka7",
"2l5t",
"2pnr",
"2q8i",
"3a7a",
"3a7l",
"3a8i"... | 71 | [
"PUB00000474",
"PUB00000614",
"PUB00002145",
"PUB00002436",
"PUB00004692"
] | [
"2649080",
"1825611",
"2061286",
"3522581",
"2682658"
] | [
"The 2-oxo acid dehydrogenase complexes: recent advances.",
"Sequence similarities within the family of dihydrolipoamide acyltransferases and discovery of a previously unidentified fungal enzyme.",
"Identification and molecular characterization of the Alcaligenes eutrophus H16 aco operon genes involved in aceto... | [
1989,
1991,
1991,
1986,
1989
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1098,
74022,
23808,
2,
1243
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
44,
3,
10,
8,
3,
38,
9,
5,
34,
23,
4,
3,
75
] | 13 | true | Binding_site | 2-oxo acid dehydrogenase, lipoyl-binding site | 2-oxo acid dehydrogenase, lipoyl-binding site | 2-oxoA_DH_lipoyl-BS | 2 |
IPR003018 | 3,018 | GAF domain | GAF | Domain | 253,190 | false | false | The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes [ , ]. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain [ ]. Adenylyl and guanyly... | [
"GO:0005515"
] | [
"protein binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PFAM",
"PFAM",
"SMART"
] | [
"PF01590",
"PF13185",
"PF13492",
"SM00065"
] | [
"GAF",
"GAF_2",
"GAF_3",
"GAF"
] | [
150593,
95520,
10086,
189113
] | 4 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-418457",
"R-BTA-445355",
"R-BTA-9013422",
"R-CEL-418457",
"R-CEL-418555",
"R-CFA-2485179",
"R-CFA-2514859",
"R-CFA-4086398",
"R-CFA-418457",
"R-CFA-445355",
"R-CFA-9013422",
"R-DME-418457",
"R-DME-445355",
"R-DME-9013422",
"R-HSA-2485179",
"R-HSA-2514859",
"R-HSA-4086398",
"... | [
"REACTOME:R-BTA-418457",
"REACTOME:R-BTA-445355",
"REACTOME:R-BTA-9013422",
"REACTOME:R-CEL-418457",
"REACTOME:R-CEL-418555",
"REACTOME:R-CFA-2485179",
"REACTOME:R-CFA-2514859",
"REACTOME:R-CFA-4086398",
"REACTOME:R-CFA-418457",
"REACTOME:R-CFA-445355",
"REACTOME:R-CFA-9013422",
"REACTOME:R-DM... | 32 | [
"1f5m",
"1mc0",
"1vhm",
"1ykd",
"1ztu",
"2k2n",
"2k31",
"2kli",
"2koi",
"2lb5",
"2lb9",
"2m7u",
"2m7v",
"2o9b",
"2o9c",
"2ool",
"2qyb",
"2vea",
"2vjw",
"2vks",
"2vzw",
"2w3d",
"2w3e",
"2w3f",
"2w3g",
"2w3h",
"2xss",
"2y79",
"2y8h",
"2zmf",
"3bjc",
"3c2w"... | 296 | [
"PUB00005474",
"PUB00021559",
"PUB00057238",
"PUB00057239",
"PUB00057240"
] | [
"9433123",
"11032796",
"1404379",
"20298248",
"20004158"
] | [
"The GAF domain: an evolutionary link between diverse phototransducing proteins.",
"Structure of the GAF domain, a ubiquitous signaling motif and a new class of cyclic GMP receptor.",
"Role of integration host factor in stimulating transcription from the sigma 54-dependent nifH promoter.",
"Phytochrome three-... | [
1997,
2000,
1992,
2010,
2009
] | 5 | [] | [
"IPR016132"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
6324,
206293,
38550,
8,
2015
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
186,
2,
46,
8,
10,
38,
26,
5,
47,
43,
1,
2,
71
] | 13 | true | Domain | GAF domain | GAF domain | GAF | 3 |
IPR003020 | 3,020 | Bicarbonate transporter, eukaryotic | HCO3_transpt_euk | Family | 33,716 | false | false | Bicarbonate (HCO 3 - ) transport mechanisms are the principal regulators of pH in animal cells. Such transport also plays a vital role in acid-base movements in the stomach, pancreas, intestine, kidney, reproductive organs and the central nervous system. Functional studies have suggested four different HCO 3 - transpor... | [
"GO:0005452",
"GO:0006820",
"GO:0016020"
] | [
"solute:inorganic anion antiporter activity",
"monoatomic anion transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS",
"PANTHER",
"NCBIFAM"
] | [
"PR01231",
"PTHR11453",
"TIGR00834"
] | [
"HCO3TRNSPORT",
"",
"ae"
] | [
23955,
33701,
20035
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-425381",
"R-HSA-1237044",
"R-HSA-1247673",
"R-HSA-425381",
"R-HSA-5619050",
"R-HSA-5619054",
"R-HSA-9013405",
"R-HSA-9013406",
"R-HSA-9013407",
"R-HSA-9013409",
"R-HSA-9035034",
"R-HSA-9925563",
"R-MMU-1237044",
"R-MMU-1247673",
"R-MMU-425381",
"R-MMU-9013405",
"R-MMU-9013406"... | [
"REACTOME:R-BTA-425381",
"REACTOME:R-HSA-1237044",
"REACTOME:R-HSA-1247673",
"REACTOME:R-HSA-425381",
"REACTOME:R-HSA-5619050",
"REACTOME:R-HSA-5619054",
"REACTOME:R-HSA-9013405",
"REACTOME:R-HSA-9013406",
"REACTOME:R-HSA-9013407",
"REACTOME:R-HSA-9013409",
"REACTOME:R-HSA-9035034",
"REACTOME:... | 26 | [
"1bzk",
"1hyn",
"4ky9",
"4yzf",
"5jho",
"5l25",
"5sv9",
"6caa",
"7rtm",
"7tvz",
"7tw0",
"7tw1",
"7tw2",
"7tw3",
"7tw5",
"7tw6",
"7ty4",
"7ty6",
"7ty7",
"7ty8",
"7tya",
"7uz3",
"7uzu",
"7uzv",
"7v07",
"7v0k",
"7v0m",
"7v0t",
"7v0u",
"7v0y",
"7v19",
"7x1g"... | 75 | [
"PUB00005997",
"PUB00006023",
"PUB00018713"
] | [
"2289848",
"9235899",
"9261985"
] | [
"Molecular biology of the anion exchanger gene family.",
"Cloning and functional expression of a human kidney Na+:HCO3- cotransporter.",
"The electrogenic Na/HCO3 cotransporter."
] | [
1990,
1997,
1997
] | 3 | [] | [
"IPR001717",
"IPR003024"
] | 0 | 2 | 0 | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
46,
33666,
4
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
32,
14,
138,
23,
63,
80,
2,
15,
72,
1,
1,
59
] | 12 | true | Family | Bicarbonate transporter, eukaryotic | Bicarbonate transporter, eukaryotic | HCO3_transpt_euk | 4 |
IPR003021 | 3,021 | Rad1/Rec1/Rad17 | Rad1_Rec1_Rad17 | Family | 4,497 | false | false | This family consists of the repair proteins Rad1, Rec1 and Rad17. Rad1 is a component of the 9-1-1 cell-cycle checkpoint response complex (Rad9-Rad1-Hus1) that plays a major role in DNA repair [ , ]. Rad1 isoform 1 possesses 3'->5' double stranded DNA exonuclease activity [ ]. Rec1 of Ustilago maydis plays a key role i... | [
"GO:0000077"
] | [
"DNA damage checkpoint signaling"
] | [
"biological_process"
] | 1 | [
"PFAM",
"PRINTS",
"PANTHER"
] | [
"PF02144",
"PR01245",
"PTHR10870"
] | [
"Rad1",
"RAD1REC1",
""
] | [
4367,
3698,
4353
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-176187",
"R-CEL-5693607",
"R-DME-176187",
"R-DME-5693607",
"R-DME-6804756",
"R-DME-69473",
"R-HSA-176187",
"R-HSA-5685938",
"R-HSA-5693607",
"R-HSA-5693616",
"R-HSA-6804756",
"R-HSA-69473",
"R-HSA-9709570",
"R-MMU-176187",
"R-MMU-5685938",
"R-MMU-5693607",
"R-MMU-6804756",
"... | [
"REACTOME:R-CEL-176187",
"REACTOME:R-CEL-5693607",
"REACTOME:R-DME-176187",
"REACTOME:R-DME-5693607",
"REACTOME:R-DME-6804756",
"REACTOME:R-DME-69473",
"REACTOME:R-HSA-176187",
"REACTOME:R-HSA-5685938",
"REACTOME:R-HSA-5693607",
"REACTOME:R-HSA-5693616",
"REACTOME:R-HSA-6804756",
"REACTOME:R-H... | 20 | [
"3a1j",
"3g65",
"3ggr",
"6j8y",
"7sgz",
"7sh2",
"7st9",
"7stb",
"7z6h",
"8dqw",
"8fs3",
"8fs4",
"8fs5",
"8fs6",
"8fs7",
"8fs8",
"8gnn",
"8wu8"
] | 18 | [
"PUB00006116",
"PUB00059226",
"PUB00059227",
"PUB00059228",
"PUB00059229",
"PUB00059230",
"PUB00062235"
] | [
"8276878",
"10359610",
"10777662",
"8649984",
"12604797",
"16137930",
"9660799"
] | [
"The REC1 gene of Ustilago maydis involved in the cellular response to DNA damage encodes an exonuclease.",
"The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1.",
"Physical interactions among human checkpoint control proteins HUS1p, RAD1p, and RAD... | [
1994,
1999,
2000,
1996,
2003,
2005,
1998
] | 7 | [] | [
"IPR003011",
"IPR003027",
"IPR016587"
] | 0 | 3 | 0 | [
"Archaea",
"Bacteroidota",
"Eukaryota"
] | [
3,
45,
4449
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
1,
1,
2,
4,
1,
5,
2,
1,
1,
2
] | 12 | true | Family | Rad1/Rec1/Rad17 | Rad1/Rec1/Rad17 | Rad1_Rec1_Rad17 | 1 |
IPR003022 | 3,022 | Transcription factor Otx2 | Otx2_TF | Family | 938 | false | false | Otx proteins constitute a class of vertebrate homeodomain-containing transcription factors that have been shown to be essential for anterior head formation, including brain morphogenesis. They are orthologous to the product of the Drosophila head gap gene, orthodenticle (Otd), and appear to play similar roles in both, ... | [
"GO:0003677",
"GO:0003700",
"GO:0007275",
"GO:0005634"
] | [
"DNA binding",
"DNA-binding transcription factor activity",
"multicellular organism development",
"nucleus"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"PRINTS"
] | [
"PR01257"
] | [
"OTX2HOMEOBOX"
] | [
938
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-9823739",
"R-HSA-9832991"
] | [
"REACTOME:R-HSA-9823739",
"REACTOME:R-HSA-9832991"
] | 2 | [] | 0 | [
"PUB00006127",
"PUB00006144",
"PUB00006146",
"PUB00006147"
] | [
"7590242",
"10199636",
"10375352",
"10440864"
] | [
"Mouse Otx2 functions in the formation and patterning of rostral head.",
"The TINS Lecture. Understanding the roles of Otx1 and Otx2 in the control of brain morphogenesis.",
"Function and evolution of Otx proteins.",
"Conserved genetic programs in insect and mammalian brain development."
] | [
1995,
1999,
1999,
1999
] | 4 | [
"IPR003025"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
938
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
5,
4,
4
] | 4 | true | Family | Transcription factor Otx2 | Transcription factor Otx2 | Otx2_TF | 9 |
IPR003024 | 3,024 | Sodium bicarbonate cotransporter | Na/HCO3_transpt | Family | 12,644 | false | false | Bicarbonate (HCO 3 - ) transport mechanisms are the principal regulators of pH in animal cells. Such transport also plays a vital role in acid-base movements in the stomach, pancreas, intestine, kidney, reproductive organs and the central nervous system. Functional studies have suggested four different HCO 3 - transpor... | [
"GO:0005452",
"GO:0006820",
"GO:0016020"
] | [
"solute:inorganic anion antiporter activity",
"monoatomic anion transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01232"
] | [
"NAHCO3TRSPRT"
] | [
12644
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-425381",
"R-HSA-425381",
"R-HSA-5619054",
"R-HSA-9925563",
"R-MMU-425381",
"R-MMU-9013405",
"R-MMU-9013406",
"R-MMU-9013407",
"R-MMU-9035034",
"R-RNO-425381"
] | [
"REACTOME:R-BTA-425381",
"REACTOME:R-HSA-425381",
"REACTOME:R-HSA-5619054",
"REACTOME:R-HSA-9925563",
"REACTOME:R-MMU-425381",
"REACTOME:R-MMU-9013405",
"REACTOME:R-MMU-9013406",
"REACTOME:R-MMU-9013407",
"REACTOME:R-MMU-9035034",
"REACTOME:R-RNO-425381"
] | 10 | [
"5jho",
"6caa"
] | 2 | [
"PUB00005997",
"PUB00006023",
"PUB00006024",
"PUB00006025",
"PUB00018713"
] | [
"2289848",
"9235899",
"9163427",
"9651366",
"9261985"
] | [
"Molecular biology of the anion exchanger gene family.",
"Cloning and functional expression of a human kidney Na+:HCO3- cotransporter.",
"Expression cloning and characterization of a renal electrogenic Na+/HCO3- cotransporter.",
"Molecular cloning, chromosomal localization, tissue distribution, and functional... | [
1990,
1997,
1997,
1998,
1997
] | 5 | [
"IPR003020"
] | [] | 1 | 0 | 1 | [
"Metazoa"
] | [
12644
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
67,
9,
17,
36,
43
] | 6 | true | Family | Sodium bicarbonate cotransporter | Sodium bicarbonate cotransporter | Na/HCO3_transpt | 1 |
IPR003026 | 3,026 | Transcription factor Otx1 | Otx1_TF | Family | 821 | false | false | Otx proteins constitute a class of vertebrate homeodomain-containing transcription factors that have been shown to be essential for anterior head formation, including brain morphogenesis. They are orthologous to the product of the Drosophila head gap gene, orthodenticle (Otd), and appear to play similar roles in both, ... | [
"GO:0003700",
"GO:0007275",
"GO:0005634"
] | [
"DNA-binding transcription factor activity",
"multicellular organism development",
"nucleus"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01256"
] | [
"OTX1HOMEOBOX"
] | [
821
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00006144",
"PUB00006146",
"PUB00006147"
] | [
"10199636",
"10375352",
"10440864"
] | [
"The TINS Lecture. Understanding the roles of Otx1 and Otx2 in the control of brain morphogenesis.",
"Function and evolution of Otx proteins.",
"Conserved genetic programs in insect and mammalian brain development."
] | [
1999,
1999,
1999
] | 3 | [
"IPR003025"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
821
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
3,
4,
2
] | 4 | true | Family | Transcription factor Otx1 | Transcription factor Otx1 | Otx1_TF | 9 |
IPR003027 | 3,027 | Exonuclease Rec1, Ustilaginaceae | Rec1_exonuc_Ustilaginaceae | Family | 30 | false | false | Rec1 of Ustilago maydis is a homologue of S. pombe Rad1 and S. cerevisiae Rad17 proteins. It plays a key role in regulating the genetic system of the fungus. Rec1 mutants are very sensitive to UV light - mutation leads to a complex phenotype with alterations in DNA repair, recombination, mutagenesis, meiosis and cell d... | [
"GO:0008311",
"GO:0005634"
] | [
"double-stranded DNA 3'-5' DNA exonuclease activity",
"nucleus"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01247"
] | [
"RECEXONCLASE"
] | [
30
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00006116"
] | [
"8276878"
] | [
"The REC1 gene of Ustilago maydis involved in the cellular response to DNA damage encodes an exonuclease."
] | [
1994
] | 1 | [
"IPR003021"
] | [] | 1 | 0 | 1 | [
"Basidiomycota"
] | [
30
] | 1 | [] | [] | 0 | true | Family | Exonuclease Rec1, Ustilaginaceae | Exonuclease Rec1, Ustilaginaceae | Rec1_exonuc_Ustilaginaceae | 6 |
IPR003028 | 3,028 | Sodium:neurotransmitter symporter, glycine, type 1 | Na/ntran_symport_glycine_GLY1 | Family | 1,418 | false | false | Neurotransmitter transport systems are integral to the release, re-uptake and recycling of neurotransmitters at synapses. High affinity transport proteins found in the plasma membrane of presynaptic nerve terminals and glial cells are responsible for the removal from the extracellular space of released-transmitters, th... | [
"GO:0005283",
"GO:0006836",
"GO:0005886",
"GO:0016020"
] | [
"amino acid:sodium symporter activity",
"neurotransmitter transport",
"plasma membrane",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component",
"cellular_component"
] | 4 | [
"PRINTS"
] | [
"PR01204"
] | [
"GLY1TRNSPORT"
] | [
1418
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-442660",
"R-MMU-442660",
"R-RNO-442660"
] | [
"REACTOME:R-HSA-442660",
"REACTOME:R-MMU-442660",
"REACTOME:R-RNO-442660"
] | 3 | [
"8wfi",
"8wfj",
"8wfk",
"8wfl",
"9j8b",
"9j8c",
"9j8d"
] | 7 | [
"PUB00001020",
"PUB00006006",
"PUB00006007",
"PUB00006008",
"PUB00006026"
] | [
"15336049",
"8811182",
"8103691",
"7823024",
"8226790"
] | [
"Cloners quick on the uptake.",
"Molecular biology of mammalian amino acid transporters.",
"Neurotransmitter transporters: three distinct gene families.",
"Neurotransmitter transporters: three important gene families for neuronal function.",
"Cloning and expression of a spinal cord- and brain-specific glyci... | [
1992,
1996,
1993,
1994,
1993
] | 5 | [
"IPR000175"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
1418
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
9,
7,
3
] | 4 | true | Family | Sodium:neurotransmitter symporter, glycine, type 1 | Sodium:neurotransmitter symporter, glycine, type 1 | Na/ntran_symport_glycine_GLY1 | 8 |
IPR003032 | 3,032 | Ryanodine receptor Ryr | Ryanodine_rcpt | Domain | 8,234 | false | false | This domain is called RyR for Ryanodine receptor [ ]. The domain is found in four copies in the ryanodine receptor. A single copy of this domain encodes an unknown protein from Bacteroides thetaiotamicron, and and suggests that the repeats in RyRs may have a prokaryotic origin [ ]. The function of this domain is unknow... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02026"
] | [
"RyR"
] | [
8234
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2672351",
"R-HSA-5578775",
"R-MMU-2672351",
"R-MMU-5578775",
"R-RNO-2672351",
"R-RNO-5578775"
] | [
"REACTOME:R-HSA-2672351",
"REACTOME:R-HSA-5578775",
"REACTOME:R-MMU-2672351",
"REACTOME:R-MMU-5578775",
"REACTOME:R-RNO-2672351",
"REACTOME:R-RNO-5578775"
] | 6 | [
"3j8h",
"3nrt",
"3rqr",
"4ert",
"4erv",
"4esu",
"4ett",
"4etu",
"4etv",
"4n05",
"4uwa",
"4uwe",
"5c30",
"5gky",
"5gkz",
"5gl0",
"5gl1",
"5go9",
"5goa",
"5j8v",
"5l1d",
"5t15",
"5t9m",
"5t9n",
"5t9r",
"5t9s",
"5t9v",
"5ta3",
"5tal",
"5tam",
"5tan",
"5tap"... | 209 | [
"PUB00006473",
"PUB00086592"
] | [
"10664581",
"22453942"
] | [
"Novel repeats in ryanodine and IP3 receptors and protein O-mannosyltransferases.",
"Ryanodine receptor calcium release channels: an evolutionary perspective."
] | [
2000,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"Viruses",
"metagenomes"
] | [
744,
7294,
18,
100,
78
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
17,
52,
7,
21,
8,
12
] | 6 | true | Domain | Ryanodine receptor Ryr | Ryanodine receptor Ryr | Ryanodine_rcpt | 8 |
IPR003033 | 3,033 | SCP2 sterol-binding domain | SCP2_sterol-bd_dom | Domain | 30,993 | false | false | This domain is involved in binding sterols, and is found in proteins such as SCP2. This domain has a 3-layer α/β/α fold, composed of α/β(3)/(crossover)/β/(α)/β. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02036"
] | [
"SCP2"
] | [
30993
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-193368",
"R-HSA-2046106",
"R-HSA-389887",
"R-HSA-390247",
"R-HSA-9033241",
"R-HSA-9033500",
"R-MMU-193368",
"R-MMU-2046106",
"R-MMU-389887",
"R-MMU-390247",
"R-MMU-9033241",
"R-RNO-193368",
"R-RNO-2046106",
"R-RNO-389887",
"R-RNO-390247",
"R-RNO-9033241"
] | [
"REACTOME:R-HSA-193368",
"REACTOME:R-HSA-2046106",
"REACTOME:R-HSA-389887",
"REACTOME:R-HSA-390247",
"REACTOME:R-HSA-9033241",
"REACTOME:R-HSA-9033500",
"REACTOME:R-MMU-193368",
"REACTOME:R-MMU-2046106",
"REACTOME:R-MMU-389887",
"REACTOME:R-MMU-390247",
"REACTOME:R-MMU-9033241",
"REACTOME:R-RN... | 16 | [
"1c44",
"1ikt",
"1pz4",
"1qnd",
"1wfr",
"2c0l",
"2cx7",
"2ksh",
"2ksi",
"2nbm",
"2nbn",
"2qzt",
"3bdq",
"3bkr",
"3bks",
"3bn8",
"3cnu",
"4jgx",
"4uei",
"6h6n",
"6h6o",
"6h6p",
"6ovp",
"6z1w",
"6z1x",
"8af2",
"8af3"
] | 27 | [
"PUB00006295",
"PUB00006350"
] | [
"8243660",
"8667025"
] | [
"NMR determination of the secondary structure and the three-dimensional polypeptide backbone fold of the human sterol carrier protein 2.",
"The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein."
] | [
1993,
1996
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
266,
18584,
11757,
386
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
2,
5,
6,
7,
2,
30,
11,
1,
7,
24,
3
] | 11 | true | Domain | SCP2 sterol-binding domain | SCP2 sterol-binding domain | SCP2_sterol-bd_dom | 3 |
IPR003034 | 3,034 | SAP domain | SAP_dom | Domain | 55,396 | false | false | The SAP motif is a 35-residue motif, which has been named after SAF-A/B, Acinus and PIAS, three proteins known to contain it. The SAP motif is found in a variety of nuclear proteins involved in transcription, DNA repair, RNA processing or apoptotic chromatin degradation. As the sap motif of SAF-A has been shown to be e... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF02037",
"PS50800",
"SM00513"
] | [
"SAP",
"SAP",
"SAP"
] | [
46639,
50515,
47408
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC50800",
"R-CEL-3899300",
"R-DRE-196791",
"R-DRE-3108214",
"R-DRE-3232142",
"R-DRE-4085377",
"R-DRE-4090294",
"R-DRE-4755510",
"R-GGA-353423",
"R-HSA-110314",
"R-HSA-111465",
"R-HSA-159236",
"R-HSA-164843",
"R-HSA-1834949",
"R-HSA-196791",
"R-HSA-3108214",
"R-HSA-3232118",
"R-H... | [
"PROSITEDOC:PDOC50800",
"REACTOME:R-CEL-3899300",
"REACTOME:R-DRE-196791",
"REACTOME:R-DRE-3108214",
"REACTOME:R-DRE-3232142",
"REACTOME:R-DRE-4085377",
"REACTOME:R-DRE-4090294",
"REACTOME:R-DRE-4755510",
"REACTOME:R-GGA-353423",
"REACTOME:R-HSA-110314",
"REACTOME:R-HSA-111465",
"REACTOME:R-HS... | 108 | [
"1h1j",
"1jeq",
"1jey",
"1jjr",
"1kcf",
"1v66",
"1zbh",
"1zbu",
"1zrj",
"2do1",
"2do5",
"2jx3",
"2kvu",
"2kw9",
"2rnn",
"2rno",
"2wqg",
"4l8r",
"4qoz",
"4uzw",
"5z56",
"5z57",
"5z58",
"6ah0",
"6ahd",
"6ff4",
"6ff7",
"6qx9",
"6y50",
"6y53",
"6y5q",
"6zha"... | 116 | [
"PUB00006479",
"PUB00018259",
"PUB00018260",
"PUB00018261",
"PUB00018262",
"PUB00018264",
"PUB00018265",
"PUB00018266"
] | [
"10694879",
"10212141",
"9671816",
"10671544",
"10490026",
"10805787",
"9862413",
"9707445"
] | [
"SAP - a putative DNA-binding motif involved in chromosomal organization.",
"A novel hnRNP protein (HAP/SAF-B) enters a subset of hnRNP complexes and relocates in nuclear granules in response to heat shock.",
"SAF-B protein couples transcription and pre-mRNA splicing to SAR/MAR elements.",
"Apoptotic cleavage... | [
2000,
1999,
1998,
2000,
1999,
2000,
1998,
1998
] | 8 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
147,
770,
54010,
196,
273
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
51,
11,
132,
33,
108,
83,
10,
38,
120,
5,
6,
166
] | 12 | true | Domain | SAP domain | SAP domain | SAP_dom | 4 |
IPR003035 | 3,035 | RWP-RK domain | RWP-RK_dom | Domain | 9,473 | false | false | This domain is found in algal minus dominance proteins as well as plant proteins involved in nitrogen-controlled development [ , ]. Proteins containing this domain include NIN-like proteins (NLPs) and RWP-RK domain proteins (RKDs). RWP-RK domain may serve in dimerisation and DNA binding [ ]. | [] | [] | [] | 0 | [
"PFAM",
"PROFILE"
] | [
"PF02042",
"PS51519"
] | [
"RWP-RK",
"RWP_RK"
] | [
9428,
9283
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00006467",
"PUB00064379",
"PUB00084567"
] | [
"10647012",
"12644653",
"24987011"
] | [
"A plant regulator controlling development of symbiotic root nodules.",
"The Sym35 gene required for root nodule development in pea is an ortholog of Nin from Lotus japonicus.",
"The plant RWP-RK transcription factors: key regulators of nitrogen responses and of gametophyte development."
] | [
1999,
2003,
2014
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati",
"metagenomes"
] | [
9465,
5,
3
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
66,
37,
78
] | 3 | true | Domain | RWP-RK domain | RWP-RK domain | RWP-RK_dom | 2 |
IPR003036 | 3,036 | Core shell protein Gag P30 | Gag_P30 | Domain | 3,321 | false | false | Gag polyprotein plays a role in budding and is processed by the viral protease during virion maturation outside the cell [ ]. It can be cleaved into 4 chains: matrix protein p15, RNA-binding phosphoprotein p12, capsid protein p30 and nucleocapsid protein p10. This entry represents the capsid protein p30. | [
"GO:0019068"
] | [
"virion assembly"
] | [
"biological_process"
] | 1 | [
"PFAM"
] | [
"PF02093"
] | [
"Gag_p30"
] | [
3321
] | 1 | [] | [] | [] | 0 | [
"1bm4",
"1u7k",
"2y4z",
"3bp9",
"6gza",
"6hww",
"6hwx",
"6hwy"
] | 8 | [
"PUB00066869"
] | [
"19864377"
] | [
"Late domain-independent rescue of a release-deficient Moloney murine leukemia virus by the ubiquitin ligase itch."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Geopseudomonas aromaticivorans",
"Viruses",
"bird metagenome"
] | [
2937,
1,
382,
1
] | 4 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
22,
4
] | 3 | true | Domain | Core shell protein Gag P30 | Core shell protein Gag P30 | Gag_P30 | 9 |
IPR003038 | 3,038 | DAD/Ost2 | DAD/Ost2 | Family | 4,273 | false | false | Members of this family are thought to be integral membrane proteins. Some members of this family have been shown to cause apoptosis if mutated [ ], these proteins are known as DAD for defender against death. The family also includes the epsilon subunit of the oligosaccharyltransferase that is involved in N-linked glyco... | [
"GO:0008250",
"GO:0016020"
] | [
"oligosaccharyltransferase complex",
"membrane"
] | [
"cellular_component",
"cellular_component"
] | 2 | [
"PFAM",
"PIRSF",
"PANTHER"
] | [
"PF02109",
"PIRSF005588",
"PTHR10705"
] | [
"DAD",
"DAD",
""
] | [
4255,
3057,
4165
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-9768727",
"R-DME-9768727",
"R-GGA-9768727",
"R-HSA-446203",
"R-HSA-9694548",
"R-HSA-9768727",
"R-MMU-9768727",
"R-RNO-9768727",
"R-SSC-9768727"
] | [
"REACTOME:R-BTA-9768727",
"REACTOME:R-DME-9768727",
"REACTOME:R-GGA-9768727",
"REACTOME:R-HSA-446203",
"REACTOME:R-HSA-9694548",
"REACTOME:R-HSA-9768727",
"REACTOME:R-MMU-9768727",
"REACTOME:R-RNO-9768727",
"REACTOME:R-SSC-9768727"
] | 9 | [
"6c26",
"6ezn",
"6s7o",
"6s7t",
"7oci",
"8agb",
"8agc",
"8age",
"8b6l",
"8pn9"
] | 10 | [
"PUB00006291",
"PUB00006334",
"PUB00063165"
] | [
"8413235",
"7593165",
"9167970"
] | [
"Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells.",
"The essential OST2 gene encodes the 16-kD subunit of the yeast oligosaccharyltransferase, a highly conserved protein expressed in diverse eukaryotic organisms.",
"The highly con... | [
1993,
1995,
1997
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Streptomyces javensis"
] | [
4272,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
8,
1,
1,
1,
5,
1,
1,
1,
4,
1,
1,
4
] | 12 | true | Family | DAD/Ost2 | DAD/Ost2 | DAD/Ost2 | 4 |
IPR003043 | 3,043 | Uroporphiryn-III C-methyltransferase, conserved site | Uropor_MeTrfase_CS | Conserved_site | 44,930 | false | false | Uroporphyrin-III C-methyltransferase ( )(SUMT) [ , ] catalyses the transfer of two methyl groups from S-adenosyl-L-methionine to the C-2 and C-7 atoms of uroporphyrinogen III to yield precorrin-2 via the intermediate formation of precorrin-1. SUMT is the first enzyme specific to the cobalamin pathway and precorrin-2 is... | [
"GO:0008168"
] | [
"methyltransferase activity"
] | [
"molecular_function"
] | 1 | [
"PROSITE",
"PROSITE"
] | [
"PS00839",
"PS00840"
] | [
"SUMT_1",
"SUMT_2"
] | [
34959,
31748
] | 2 | [
"EC",
"EC",
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"PROSITEDOC"
] | [
"1.3.1.76",
"2.1.1",
"2.1.1.107",
"4.99.1.4",
"PWY-5194",
"PWY-5196",
"PWY-7377",
"PDOC00656"
] | [
"EC:1.3.1.76",
"EC:2.1.1",
"EC:2.1.1.107",
"EC:4.99.1.4",
"METACYC:PWY-5194",
"METACYC:PWY-5196",
"METACYC:PWY-7377",
"PROSITEDOC:PDOC00656"
] | 8 | [
"1cbf",
"1pjq",
"1pjs",
"1pjt",
"1s4d",
"1v9a",
"1va0",
"1ve2",
"2cbf",
"2e0k",
"2e0n",
"2ybo",
"2ybq",
"3ndc",
"3nei",
"4e16",
"4gr4",
"4gr5",
"6p5x",
"6p5z",
"6p7c",
"6p7d",
"6pqz",
"6pr0",
"6pr1",
"6pr2",
"6pr3",
"6pr4",
"6ulu",
"6veb"
] | 30 | [
"PUB00002120",
"PUB00002147",
"PUB00002148",
"PUB00015329"
] | [
"2211521",
"1856165",
"1906874",
"8501034"
] | [
"Genetic and sequence analysis of an 8.7-kilobase Pseudomonas denitrificans fragment carrying eight genes involved in transformation of precorrin-2 to cobyrinic acid.",
"Purification, characterization, and molecular cloning of S-adenosyl-L-methionine: uroporphyrinogen III methyltransferase from Methanobacterium i... | [
1990,
1991,
1991,
1993
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1456,
41058,
2033,
383
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
7,
1,
3,
1,
1,
11
] | 6 | true | Conserved_site | Uroporphiryn-III C-methyltransferase, conserved site | Uroporphiryn-III C-methyltransferase, conserved site | Uropor_MeTrfase_CS | 7 |
IPR003044 | 3,044 | P2X1 purinoceptor | P2X1_purnocptor | Family | 1,007 | false | false | P2X purinoceptors are cell membrane ion channels, gated by adenosine 5'-triphosphate (ATP) and other nucleotides; they have been found to be widely expressed on mammalian cells, and, by means of their functional properties, can be differentiated into three sub-groups. The first group is almost equally well activated by... | [
"GO:0001614",
"GO:0005216",
"GO:0005524",
"GO:0006811",
"GO:0016020"
] | [
"purinergic nucleotide receptor activity",
"monoatomic ion channel activity",
"ATP binding",
"monoatomic ion transport",
"membrane"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 5 | [
"PRINTS"
] | [
"PR01308"
] | [
"P2X1RECEPTOR"
] | [
1007
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-139853",
"R-HSA-418346",
"R-HSA-6798695",
"R-MMU-139853",
"R-MMU-418346",
"R-MMU-6798695",
"R-RNO-139853",
"R-RNO-418346",
"R-RNO-6798695"
] | [
"REACTOME:R-HSA-139853",
"REACTOME:R-HSA-418346",
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-139853",
"REACTOME:R-MMU-418346",
"REACTOME:R-MMU-6798695",
"REACTOME:R-RNO-139853",
"REACTOME:R-RNO-418346",
"REACTOME:R-RNO-6798695"
] | 9 | [
"8zt1",
"8zt2",
"8zt5",
"8zt8",
"8zta",
"8ztd",
"8ztf",
"9b73",
"9b95",
"9c2a",
"9c2b",
"9c2c",
"9lx5",
"9lxc"
] | 14 | [
"PUB00006451",
"PUB00007054",
"PUB00100494"
] | [
"10414359",
"12270951",
"29631184"
] | [
"Functional and molecular diversity of purinergic ion channel receptors.",
"Molecular physiology of P2X receptors.",
"Modulation of innate and adaptive immunity by P2X ion channels."
] | [
1999,
2002,
2018
] | 3 | [
"IPR001429"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
1007
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
3,
7
] | 4 | true | Family | P2X1 purinoceptor | P2X1 purinoceptor | P2X1_purnocptor | 2 |
IPR003045 | 3,045 | P2X2 purinoceptor | P2X2_purnocptor | Family | 1,025 | false | false | P2X purinoceptors are cell membrane ion channels, gated by adenosine 5'-triphosphate (ATP) and other nucleotides; they have been found to be widely expressed on mammalian cells, and, by means of their functional properties, can be differentiated into three sub-groups. The first group is almost equally well activated by... | [
"GO:0001614",
"GO:0005216",
"GO:0005524",
"GO:0006811",
"GO:0016020"
] | [
"purinergic nucleotide receptor activity",
"monoatomic ion channel activity",
"ATP binding",
"monoatomic ion transport",
"membrane"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 5 | [
"PRINTS"
] | [
"PR01309"
] | [
"P2X2RECEPTOR"
] | [
1025
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-139853",
"R-HSA-418346",
"R-MMU-139853",
"R-MMU-418346",
"R-RNO-139853",
"R-RNO-418346"
] | [
"REACTOME:R-HSA-139853",
"REACTOME:R-HSA-418346",
"REACTOME:R-MMU-139853",
"REACTOME:R-MMU-418346",
"REACTOME:R-RNO-139853",
"REACTOME:R-RNO-418346"
] | 6 | [
"9ddv",
"9ddw",
"9ddx"
] | 3 | [
"PUB00006451",
"PUB00007054",
"PUB00100494"
] | [
"10414359",
"12270951",
"29631184"
] | [
"Functional and molecular diversity of purinergic ion channel receptors.",
"Molecular physiology of P2X receptors.",
"Modulation of innate and adaptive immunity by P2X ion channels."
] | [
1999,
2002,
2018
] | 3 | [
"IPR001429"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
1025
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
2,
1,
12
] | 4 | true | Family | P2X2 purinoceptor | P2X2 purinoceptor | P2X2_purnocptor | 5 |
IPR003046 | 3,046 | P2X3 purinoceptor | P2X3_purnocptor | Family | 980 | false | false | P2X purinoceptors are cell membrane ion channels, gated by adenosine 5'-triphosphate (ATP) and other nucleotides; they have been found to be widely expressed on mammalian cells, and, by means of their functional properties, can be differentiated into three sub-groups. The first group is almost equally well activated by... | [
"GO:0001614",
"GO:0005216",
"GO:0005524",
"GO:0006811",
"GO:0016020"
] | [
"purinergic nucleotide receptor activity",
"monoatomic ion channel activity",
"ATP binding",
"monoatomic ion transport",
"membrane"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 5 | [
"PRINTS"
] | [
"PR01310"
] | [
"P2X3RECEPTOR"
] | [
980
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-139853",
"R-HSA-418346",
"R-MMU-139853",
"R-MMU-418346",
"R-RNO-139853",
"R-RNO-418346"
] | [
"REACTOME:R-HSA-139853",
"REACTOME:R-HSA-418346",
"REACTOME:R-MMU-139853",
"REACTOME:R-MMU-418346",
"REACTOME:R-RNO-139853",
"REACTOME:R-RNO-418346"
] | 6 | [
"5svj",
"5svk",
"5svl",
"5svm",
"5svp",
"5svq",
"5svr",
"5svs",
"5svt",
"5yve",
"6ah4",
"6ah5",
"9bpc",
"9bpd",
"9ik1"
] | 15 | [
"PUB00006451",
"PUB00007054",
"PUB00100494"
] | [
"10414359",
"12270951",
"29631184"
] | [
"Functional and molecular diversity of purinergic ion channel receptors.",
"Molecular physiology of P2X receptors.",
"Modulation of innate and adaptive immunity by P2X ion channels."
] | [
1999,
2002,
2018
] | 3 | [
"IPR001429"
] | [] | 1 | 0 | 1 | [
"Vertebrata"
] | [
980
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
1,
3,
8
] | 4 | true | Family | P2X3 purinoceptor | P2X3 purinoceptor | P2X3_purnocptor | 8 |
IPR003047 | 3,047 | P2X4 purinoceptor | P2X4_purnocptor | Family | 990 | false | false | The P2X4 receptor (along with P2X2, P2X5 and P2X6) falls into a group of receptors that are sensitive to ATP, but not alphabetamethyleneATP. There is some evidence that P2X4 may heteropolymerise with P2X6, since they are often found together in native tissues, and can be co-immunoprecipitated. Splice variants of the P2... | [
"GO:0001614",
"GO:0005216",
"GO:0005524",
"GO:0006811",
"GO:0016020"
] | [
"purinergic nucleotide receptor activity",
"monoatomic ion channel activity",
"ATP binding",
"monoatomic ion transport",
"membrane"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 5 | [
"PRINTS"
] | [
"PR01311"
] | [
"P2X4RECEPTOR"
] | [
990
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-139853",
"R-BTA-418346",
"R-DRE-139853",
"R-DRE-418346",
"R-HSA-139853",
"R-HSA-418346",
"R-HSA-9660826",
"R-MMU-139853",
"R-MMU-418346",
"R-RNO-139853",
"R-RNO-418346"
] | [
"REACTOME:R-BTA-139853",
"REACTOME:R-BTA-418346",
"REACTOME:R-DRE-139853",
"REACTOME:R-DRE-418346",
"REACTOME:R-HSA-139853",
"REACTOME:R-HSA-418346",
"REACTOME:R-HSA-9660826",
"REACTOME:R-MMU-139853",
"REACTOME:R-MMU-418346",
"REACTOME:R-RNO-139853",
"REACTOME:R-RNO-418346"
] | 11 | [
"3h9v",
"3i5d",
"4dw0",
"4dw1",
"5wzy",
"8jv5",
"8jv6",
"9bqh",
"9bqi",
"9c48"
] | 10 | [
"PUB00006451",
"PUB00007054",
"PUB00100494"
] | [
"10414359",
"12270951",
"29631184"
] | [
"Functional and molecular diversity of purinergic ion channel receptors.",
"Molecular physiology of P2X receptors.",
"Modulation of innate and adaptive immunity by P2X ion channels."
] | [
1999,
2002,
2018
] | 3 | [
"IPR001429"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
990
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
10,
9,
10
] | 4 | true | Family | P2X4 purinoceptor | P2X4 purinoceptor | P2X4_purnocptor | 6 |
IPR003049 | 3,049 | P2X6 purinoceptor | P2X6_purnocptor | Family | 683 | false | false | P2X purinoceptors are cell membrane ion channels, gated by adenosine 5'-triphosphate (ATP) and other nucleotides; they have been found to be widely expressed on mammalian cells, and, by means of their functional properties, can be differentiated into three sub-groups. The first group is almost equally well activated by... | [
"GO:0001614",
"GO:0005216",
"GO:0005524",
"GO:0006811",
"GO:0016020"
] | [
"purinergic nucleotide receptor activity",
"monoatomic ion channel activity",
"ATP binding",
"monoatomic ion transport",
"membrane"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 5 | [
"PRINTS"
] | [
"PR01313"
] | [
"P2X6RECEPTOR"
] | [
683
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-139853",
"R-HSA-418346",
"R-MMU-139853",
"R-MMU-418346",
"R-RNO-139853",
"R-RNO-418346"
] | [
"REACTOME:R-HSA-139853",
"REACTOME:R-HSA-418346",
"REACTOME:R-MMU-139853",
"REACTOME:R-MMU-418346",
"REACTOME:R-RNO-139853",
"REACTOME:R-RNO-418346"
] | 6 | [] | 0 | [
"PUB00006451",
"PUB00007054",
"PUB00100494",
"PUB00100495"
] | [
"10414359",
"12270951",
"29631184",
"22230887"
] | [
"Functional and molecular diversity of purinergic ion channel receptors.",
"Molecular physiology of P2X receptors.",
"Modulation of innate and adaptive immunity by P2X ion channels.",
"Distribution of the purinegic receptors P2X(4) and P2X(6) during rat gut development."
] | [
1999,
2002,
2018,
2012
] | 4 | [
"IPR001429"
] | [] | 1 | 0 | 1 | [
"Tetrapoda"
] | [
683
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
4,
5
] | 3 | true | Family | P2X6 purinoceptor | P2X6 purinoceptor | P2X6_purnocptor | 4 |
IPR003050 | 3,050 | P2X7 purinoceptor | P2X7_purinoceptor | Family | 814 | false | false | P2X purinoceptors are cell membrane ion channels, gated by adenosine 5'-triphosphate (ATP) and other nucleotides; they have been found to be widely expressed on mammalian cells, and, by means of their functional properties, can be differentiated into three sub-groups. The first group is almost equally well activated by... | [
"GO:0001614",
"GO:0005216",
"GO:0005524",
"GO:0006811",
"GO:0016020"
] | [
"purinergic nucleotide receptor activity",
"monoatomic ion channel activity",
"ATP binding",
"monoatomic ion transport",
"membrane"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 5 | [
"PRINTS"
] | [
"PR01314"
] | [
"P2X7RECEPTOR"
] | [
814
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-139853",
"R-HSA-418346",
"R-HSA-844456",
"R-HSA-9660826",
"R-HSA-9856532",
"R-MMU-139853",
"R-MMU-418346",
"R-MMU-844456",
"R-RNO-139853",
"R-RNO-418346",
"R-RNO-844456"
] | [
"REACTOME:R-HSA-139853",
"REACTOME:R-HSA-418346",
"REACTOME:R-HSA-844456",
"REACTOME:R-HSA-9660826",
"REACTOME:R-HSA-9856532",
"REACTOME:R-MMU-139853",
"REACTOME:R-MMU-418346",
"REACTOME:R-MMU-844456",
"REACTOME:R-RNO-139853",
"REACTOME:R-RNO-418346",
"REACTOME:R-RNO-844456"
] | 11 | [
"5u1l",
"5u1u",
"5u1v",
"5u1w",
"5u1x",
"5u1y",
"5u2h",
"6u9v",
"6u9w",
"8jv7",
"8jv8",
"8tr5",
"8tr6",
"8tr7",
"8tr8",
"8tra",
"8trb",
"8trj",
"8trk",
"8v4s",
"8z0z",
"8z1d",
"9e3m",
"9e3n",
"9e3o",
"9e3p",
"9e3q"
] | 27 | [
"PUB00006451",
"PUB00007054",
"PUB00100494"
] | [
"10414359",
"12270951",
"29631184"
] | [
"Functional and molecular diversity of purinergic ion channel receptors.",
"Molecular physiology of P2X receptors.",
"Modulation of innate and adaptive immunity by P2X ion channels."
] | [
1999,
2002,
2018
] | 3 | [
"IPR001429"
] | [] | 1 | 0 | 1 | [
"Eumetazoa"
] | [
814
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
14,
10,
9
] | 4 | true | Family | P2X7 purinoceptor | P2X7 purinoceptor | P2X7_purinoceptor | 7 |
IPR003051 | 3,051 | GPCR, family 2, corticotropin releasing factor receptor | GPCR_2_CRF_rcpt | Family | 3,540 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0004930",
"GO:0016020"
] | [
"G protein-coupled receptor activity",
"membrane"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01279"
] | [
"CRFRECEPTOR"
] | [
3540
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-373080",
"R-HSA-418555",
"R-HSA-422085",
"R-MMU-373080",
"R-MMU-418555",
"R-RNO-373080"
] | [
"REACTOME:R-HSA-373080",
"REACTOME:R-HSA-418555",
"REACTOME:R-HSA-422085",
"REACTOME:R-MMU-373080",
"REACTOME:R-MMU-418555",
"REACTOME:R-RNO-373080"
] | 6 | [
"1u34",
"2jnc",
"2jnd",
"2l27",
"6p9x",
"6pb0",
"6pb1",
"7try",
"7ts0",
"8gtg",
"8gti",
"8gtm"
] | 12 | [
"PUB00001208",
"PUB00004310",
"PUB00004961",
"PUB00005147",
"PUB00005148",
"PUB00006292",
"PUB00006294",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816",
"PUB00100493"
] | [
"1646711",
"1314625",
"8170923",
"1658940",
"1658941",
"7692441",
"8243652",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293",
"23863939"
] | [
"Molecular cloning and expression of a cDNA encoding the secretin receptor.",
"Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide.",
"Fingerprinting G-protein-coupled receptors.",
"Expression cloning of an adenylate cyclase-coupled calcitonin receptor.",
... | [
1991,
1992,
1994,
1991,
1991,
1993,
1993,
2003,
1994,
2005,
2009,
2006,
2013,
2013
] | 14 | [
"IPR000832"
] | [
"IPR003052",
"IPR003053"
] | 1 | 2 | 0 | [
"Bilateria"
] | [
3540
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
17,
10,
20
] | 4 | true | Family | GPCR, family 2, corticotropin releasing factor receptor | GPCR, family 2, corticotropin releasing factor receptor | GPCR_2_CRF_rcpt | 4 |
IPR003052 | 3,052 | GPCR, family 2, corticotropin releasing factor receptor, type 1 | GPCR_2_CRF1_rcpt | Family | 1,197 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0004930",
"GO:0016020"
] | [
"G protein-coupled receptor activity",
"membrane"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01280"
] | [
"CRFRECEPTOR1"
] | [
1197
] | 1 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"212",
"R-HSA-373080",
"R-HSA-418555",
"R-MMU-373080",
"R-MMU-418555",
"R-RNO-373080"
] | [
"IUPHAR:212",
"REACTOME:R-HSA-373080",
"REACTOME:R-HSA-418555",
"REACTOME:R-MMU-373080",
"REACTOME:R-MMU-418555",
"REACTOME:R-RNO-373080"
] | 6 | [
"2l27",
"6p9x",
"6pb0",
"8gtg",
"8gti",
"8gtm"
] | 6 | [
"PUB00001208",
"PUB00004310",
"PUB00004961",
"PUB00005147",
"PUB00005148",
"PUB00006292",
"PUB00006294",
"PUB00006340",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816",
"PUB00100493"
] | [
"1646711",
"1314625",
"8170923",
"1658940",
"1658941",
"7692441",
"8243652",
"8536612",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293",
"23863939"
] | [
"Molecular cloning and expression of a cDNA encoding the secretin receptor.",
"Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide.",
"Fingerprinting G-protein-coupled receptors.",
"Expression cloning of an adenylate cyclase-coupled calcitonin receptor.",
... | [
1991,
1992,
1994,
1991,
1991,
1993,
1993,
1996,
2003,
1994,
2005,
2009,
2006,
2013,
2013
] | 15 | [
"IPR003051"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
1197
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
10,
3,
11
] | 4 | true | Family | GPCR, family 2, corticotropin releasing factor receptor, type 1 | GPCR, family 2, corticotropin releasing factor receptor, type 1 | GPCR_2_CRF1_rcpt | 5 |
IPR003053 | 3,053 | GPCR, family 2, corticotropin releasing factor receptor, type 2 | GPCR_2_CRF2_rcpt | Family | 1,364 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0004930",
"GO:0016020"
] | [
"G protein-coupled receptor activity",
"membrane"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01281"
] | [
"CRFRECEPTOR2"
] | [
1364
] | 1 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"213",
"R-HSA-373080",
"R-HSA-418555",
"R-HSA-422085",
"R-MMU-373080",
"R-MMU-418555",
"R-RNO-373080"
] | [
"IUPHAR:213",
"REACTOME:R-HSA-373080",
"REACTOME:R-HSA-418555",
"REACTOME:R-HSA-422085",
"REACTOME:R-MMU-373080",
"REACTOME:R-MMU-418555",
"REACTOME:R-RNO-373080"
] | 7 | [
"1u34",
"2jnc",
"2jnd",
"6pb1",
"7try",
"7ts0"
] | 6 | [
"PUB00001208",
"PUB00004310",
"PUB00004961",
"PUB00005147",
"PUB00005148",
"PUB00006292",
"PUB00006294",
"PUB00006316",
"PUB00006339",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816",
"PUB00100493"
] | [
"1646711",
"1314625",
"8170923",
"1658940",
"1658941",
"7692441",
"8243652",
"7846062",
"8536644",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293",
"23863939"
] | [
"Molecular cloning and expression of a cDNA encoding the secretin receptor.",
"Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide.",
"Fingerprinting G-protein-coupled receptors.",
"Expression cloning of an adenylate cyclase-coupled calcitonin receptor.",
... | [
1991,
1992,
1994,
1991,
1991,
1993,
1993,
1995,
1996,
2003,
1994,
2005,
2009,
2006,
2013,
2013
] | 16 | [
"IPR003051"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
1364
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
4,
8
] | 4 | true | Family | GPCR, family 2, corticotropin releasing factor receptor, type 2 | GPCR, family 2, corticotropin releasing factor receptor, type 2 | GPCR_2_CRF2_rcpt | 1 |
IPR003054 | 3,054 | Keratin, type II | Keratin_II | Family | 14,161 | false | false | Intermediate filaments (IF) [ , , ] are proteins which are primordial components of the cytoskeleton and the nuclear envelope. They generally form filamentous structures 8 to 14 nm wide. Type II keratins are the basic or neutral courterparts to the acidic type I keratins. Each type II keratin forms a heterodimer with a... | [
"GO:0045095"
] | [
"keratin filament"
] | [
"cellular_component"
] | 1 | [
"PRINTS"
] | [
"PR01276"
] | [
"TYPE2KERATIN"
] | [
14161
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-6805567",
"R-BTA-6809371",
"R-DRE-6798695",
"R-DRE-6805567",
"R-DRE-6809371",
"R-HSA-446107",
"R-HSA-6798695",
"R-HSA-6805567",
"R-HSA-6809371",
"R-HSA-9725554",
"R-HSA-9925563",
"R-HSA-9927432",
"R-HSA-9938206",
"R-MMU-446107",
"R-MMU-6798695",
"R-MMU-6805567",
"R-MMU-6809371... | [
"REACTOME:R-BTA-6805567",
"REACTOME:R-BTA-6809371",
"REACTOME:R-DRE-6798695",
"REACTOME:R-DRE-6805567",
"REACTOME:R-DRE-6809371",
"REACTOME:R-HSA-446107",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-6805567",
"REACTOME:R-HSA-6809371",
"REACTOME:R-HSA-9725554",
"REACTOME:R-HSA-9925563",
"REACTOME... | 21 | [
"3tnu",
"4zry",
"6uui"
] | 3 | [
"PUB00000058",
"PUB00001053",
"PUB00004976",
"PUB00101074"
] | [
"3052284",
"2183847",
"8771189",
"2483326"
] | [
"Molecular and cellular biology of intermediate filaments.",
"Intermediate filaments: structure, assembly and molecular interactions.",
"Intermediate filament proteins.",
"A type II keratin is expressed in glial cells of the goldfish visual pathway."
] | [
1988,
1990,
1995,
1989
] | 4 | [] | [] | 0 | 0 | null | [
"Bilateria",
"Ciceribacter ferrooxidans"
] | [
14159,
2
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
65,
54,
76
] | 4 | true | Family | Keratin, type II | Keratin, type II | Keratin_II | 9 |
IPR003055 | 3,055 | Nucleoside-specific channel-forming protein Tsx | Channel_Tsx | Family | 1,895 | false | false | The tsx gene of Escherichia coli encodes an outer membrane protein, Tsx, which constitutes the receptor for colicin K and Bacteriophage T6, and functions as a substrate-specific channel for nucleosides and deoxy- nucleosides [ ]. The protein contains 294 amino acids, the first 22 of which are characteristic of a bacter... | [
"GO:0005337",
"GO:0009279"
] | [
"nucleoside transmembrane transporter activity",
"cell outer membrane"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01277"
] | [
"CHANNELTSX"
] | [
1895
] | 1 | [] | [] | [] | 0 | [
"1tlw",
"1tly",
"1tlz"
] | 3 | [
"PUB00006257"
] | [
"2265760"
] | [
"Analysis of the tsx gene, which encodes a nucleoside-specific channel-forming protein (Tsx) in the outer membrane of Escherichia coli."
] | [
1990
] | 1 | [
"IPR018013"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Beauveria bassiana D1-5",
"metagenomes"
] | [
1892,
1,
2
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Nucleoside-specific channel-forming protein Tsx | Nucleoside-specific channel-forming protein Tsx | Channel_Tsx | 7 |
IPR003056 | 3,056 | GPCR, family 2, ADGRE2/ADGRE5 | GPCR_2_ADGRE2_ADGRE5 | Family | 1,487 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0004930",
"GO:0016020"
] | [
"G protein-coupled receptor activity",
"membrane"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01278"
] | [
"CD97PROTEIN"
] | [
1487
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-373080",
"R-HSA-6798695",
"R-MMU-373080",
"R-MMU-6798695"
] | [
"REACTOME:R-HSA-373080",
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-373080",
"REACTOME:R-MMU-6798695"
] | 4 | [
"2bo2",
"2bou",
"2box",
"7do4",
"7ydh",
"7ydj",
"7ydm",
"7ydp",
"8ikj",
"8ikl",
"9mqr"
] | 11 | [
"PUB00001208",
"PUB00004310",
"PUB00004961",
"PUB00005147",
"PUB00005148",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816",
"PUB00094000",
"PUB00094001"
] | [
"1646711",
"1314625",
"8170923",
"1658940",
"1658941",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293",
"31969668",
"26841242"
] | [
"Molecular cloning and expression of a cDNA encoding the secretin receptor.",
"Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide.",
"Fingerprinting G-protein-coupled receptors.",
"Expression cloning of an adenylate cyclase-coupled calcitonin receptor.",
... | [
1991,
1992,
1994,
1991,
1991,
2003,
1994,
2005,
2009,
2006,
2013,
2020,
2016
] | 13 | [
"IPR000832"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
1487
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
14,
17,
6,
9
] | 4 | true | Family | GPCR, family 2, ADGRE2/ADGRE5 | GPCR, family 2, ADGRE2/ADGRE5 | GPCR_2_ADGRE2_ADGRE5 | 5 |
IPR003057 | 3,057 | Invertebrate colouration protein | Invtbrt_color | Family | 2,111 | false | false | The lipocalins are a diverse, interesting, yet poorly understood family of proteins composed, in the main, of extracellular ligand-binding proteins displaying high specificity for small hydrophobic molecules [ ]. Functions of these proteins include transport of nutrients, control of cell regulation, pheromone transport... | [
"GO:0031409"
] | [
"pigment binding"
] | [
"molecular_function"
] | 1 | [
"PRINTS"
] | [
"PR01273"
] | [
"INVTBRTCOLOR"
] | [
2111
] | 1 | [] | [] | [] | 0 | [
"1bbp",
"1gka",
"1h91",
"1i4u",
"1kxo",
"1lke",
"1lnm",
"1n0s",
"1obq",
"1obu",
"1s2p",
"1s44",
"1t0v",
"1z24",
"4alo",
"5ez2",
"5f1e",
"5f6z",
"7o2y",
"7o3k",
"7vnl",
"7vns",
"7yx1"
] | 23 | [
"PUB00000205",
"PUB00003448",
"PUB00005013",
"PUB00005094"
] | [
"1834059",
"8573354",
"7684291",
"2580349"
] | [
"Mouse oncogene protein 24p3 is a member of the lipocalin protein family.",
"Multiple molecular recognition properties of the lipocalin protein family.",
"Structure and sequence relationships in the lipocalins and related proteins.",
"Homology of beta-lactoglobulin, serum retinol-binding protein, and protein ... | [
1991,
1995,
1993,
1985
] | 4 | [
"IPR022271"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
2111
] | 1 | [
"Drosophila melanogaster"
] | [
3
] | 1 | true | Family | Invertebrate colouration protein | Invertebrate colouration protein | Invtbrt_color | 2 |
IPR003059 | 3,059 | Colicin lysis protein | Lysis_col | Family | 220 | false | false | The DNA sequence of the entire colicin E2 operon has been determined [ ]. The operon comprises the colicin activity gene (ceaB), the colicin immunity gene (ceiB) and the lysis gene (celB), which is essential for colicin release from producing cells [ ]. A putative LexA binding site is located upstream from ceaB, and a ... | [
"GO:0019835",
"GO:0019867"
] | [
"cytolysis",
"outer membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PRINTS"
] | [
"PF02402",
"PR01297"
] | [
"Lysis_col",
"LYSISCOLICIN"
] | [
220,
214
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00006228",
"PUB00006230",
"PUB00006233"
] | [
"6253914",
"3892228",
"3936034"
] | [
"Molecular structure of the immunity gene and immunity protein of the bacteriocinogenic plasmid Clo DF13.",
"Molecular characterisation of the colicin E2 operon and identification of its products.",
"Structural and functional organization of the colicin E1 operon."
] | [
1980,
1985,
1985
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Plasmid ColE3-CA38"
] | [
219,
1
] | 2 | [] | [] | 0 | true | Family | Colicin lysis protein | Colicin lysis protein | Lysis_col | 1 |
IPR003060 | 3,060 | Pyocin S killer protein | Pyocin_killer | Family | 579 | false | false | Pyocins are polypeptide toxins produced by, and active against, bacteria. S-type pyocins cause cell death by DNA breakdown due to endonuclease activity [ ]. Pyocins S1 and S2 are S-type bacteriocins of Pseudomonas aeruginosa with different receptor recognition specificities [ ]. The genetic determinants of these pyocin... | [
"GO:0004519",
"GO:0005102",
"GO:0009617",
"GO:0019835"
] | [
"endonuclease activity",
"signaling receptor binding",
"response to bacterium",
"cytolysis"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"biological_process"
] | 4 | [
"PRINTS"
] | [
"PR01300"
] | [
"PYOCINKILLER"
] | [
579
] | 1 | [] | [] | [] | 0 | [
"1bxi",
"1emv",
"1fr2",
"1fsj",
"1m08",
"1mz8",
"1pt3",
"1ujz",
"1v13",
"1v14",
"1v15",
"1zns",
"1znv",
"2erh",
"2gyk",
"2gze",
"2gzf",
"2gzg",
"2gzi",
"2gzj",
"2ivh",
"2jaz",
"2jb0",
"2jbg",
"2k5x",
"2vln",
"2vlo",
"2vlp",
"2vlq",
"2wpt",
"3fbd",
"3gjn"... | 41 | [
"PUB00006283",
"PUB00012947"
] | [
"8491711",
"12423794"
] | [
"Molecular structures and functions of pyocins S1 and S2 in Pseudomonas aeruginosa.",
"The pyocins of Pseudomonas aeruginosa."
] | [
1993,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Dreissena polymorpha"
] | [
575,
4
] | 2 | [] | [] | 0 | true | Family | Pyocin S killer protein | Pyocin S killer protein | Pyocin_killer | 9 |
IPR003061 | 3,061 | Colicin E1 (microcin) immunity protein | Microcin | Family | 350 | false | false | The structural and functional relationships among independently cloned segments of the plasmid ColE1 region that regulates and codes for colicin E1 (cea), immunity (imm) and the mitomycin C-induced lethality function (lys) have been analysed [ ]. A model for the structure and expression of the colicin E1 operon has bee... | [
"GO:0015643",
"GO:0030153"
] | [
"toxic substance binding",
"bacteriocin immunity"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PRINTS"
] | [
"PF03526",
"PR01298"
] | [
"Microcin",
"MICROCIN"
] | [
345,
72
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00006227",
"PUB00006233"
] | [
"384144",
"3936034"
] | [
"Nucleotide sequence of small ColE1 derivatives: structure of the regions essential for autonomous replication and colicin E1 immunity.",
"Structural and functional organization of the colicin E1 operon."
] | [
1979,
1985
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
350
] | 1 | [] | [] | 0 | true | Family | Colicin E1 (microcin) immunity protein | Colicin E1 (microcin) immunity protein | Microcin | 2 |
IPR003063 | 3,063 | Cloacin immunity protein family | Cloacn_immnty_fam | Family | 343 | false | false | The cloacin immunity protein complexes with cloacin in equimolar quantities and inhibits it by binding with high affinity to the cloacin C-terminal catalytic domain. The immunity protein is relatively small, containing 85 amino acids. An extra ribosome binding site has been found to precede the immunity gene on the pol... | [
"GO:0015643",
"GO:0030153"
] | [
"toxic substance binding",
"bacteriocin immunity"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PRINTS"
] | [
"PF03513",
"PR01296"
] | [
"Cloacin_immun",
"CLOACNIMMNTY"
] | [
343,
330
] | 2 | [] | [] | [] | 0 | [
"1e44",
"1jch",
"2b5u",
"3eip",
"4udm"
] | 5 | [
"PUB00006228"
] | [
"6253914"
] | [
"Molecular structure of the immunity gene and immunity protein of the bacteriocinogenic plasmid Clo DF13."
] | [
1980
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
343
] | 1 | [] | [] | 0 | true | Family | Cloacin immunity protein family | Cloacin immunity protein family | Cloacn_immnty_fam | 7 |
IPR003064 | 3,064 | Norrie disease protein | Norrie_dis | Family | 803 | false | false | null | [
"GO:0016055",
"GO:0005615"
] | [
"Wnt signaling pathway",
"extracellular space"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PRINTS",
"PANTHER"
] | [
"PR01304",
"PTHR28611"
] | [
"NORRIEDSEASE",
""
] | [
785,
801
] | 2 | [] | [] | [] | 0 | [
"5bpu",
"5bq8",
"5bqb",
"5bqc",
"5bqe",
"8wvx",
"8wvy",
"9khh",
"9uok"
] | 9 | [
"PUB00003893",
"PUB00006285",
"PUB00006286"
] | [
"8298646",
"1303235",
"1303236"
] | [
"Molecular modelling of the Norrie disease protein predicts a cystine knot growth factor tertiary structure.",
"Isolation of a candidate gene for Norrie disease by positional cloning.",
"Isolation and characterization of a candidate gene for Norrie disease."
] | [
1993,
1992,
1992
] | 3 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
803
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
1,
3
] | 4 | true | Family | Norrie disease protein | Norrie disease protein | Norrie_dis | 1 |
IPR003065 | 3,065 | Surface presentation of antigens protein SpaK | Invas_SpaK | Family | 700 | false | false | The surface presentation of antigens protein SpaK (also known as InvB) from Salmonella typhimurium is involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells [ , ]. Other Spa genes in the cluster are related to invasion (In... | [] | [] | [] | 0 | [
"PFAM",
"PRINTS"
] | [
"PF03519",
"PR01305"
] | [
"Invas_SpaK",
"SSPAKPROTEIN"
] | [
688,
599
] | 2 | [
"GP"
] | [
"GenProp0052"
] | [
"GP:GenProp0052"
] | 1 | [
"1ry9",
"2fm8",
"2xga"
] | 3 | [
"PUB00001240",
"PUB00005977",
"PUB00005978",
"PUB00006307",
"PUB00007210",
"PUB00067868"
] | [
"8404849",
"7752894",
"10066464",
"8045880",
"9159221",
"16547027"
] | [
"Cognate gene clusters govern invasion of host epithelial cells by Salmonella typhimurium and Shigella flexneri.",
"Functional analysis of the Salmonella typhimurium invasion genes invl and invJ and identification of a target of the protein secretion apparatus encoded in the inv locus.",
"Vaccination against en... | [
1993,
1995,
1998,
1994,
1996,
2006
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
700
] | 1 | [] | [] | 0 | true | Family | Surface presentation of antigens protein SpaK | Surface presentation of antigens protein SpaK | Invas_SpaK | 7 |
IPR003066 | 3,066 | Salmonella invasion protein InvJ | Invas_InvJ | Family | 583 | false | false | null | [] | [] | [] | 0 | [
"NCBIFAM",
"PIRSF",
"PRINTS"
] | [
"NF011862",
"PIRSF020738",
"PR01306"
] | [
"PRK15334.1",
"Invas_invJ",
"SSPANPROTEIN"
] | [
549,
559,
582
] | 3 | [] | [] | [] | 0 | [] | 0 | [
"PUB00001240",
"PUB00005977",
"PUB00005978",
"PUB00005979",
"PUB00005980"
] | [
"8404849",
"7752894",
"10066464",
"9068645",
"8751894"
] | [
"Cognate gene clusters govern invasion of host epithelial cells by Salmonella typhimurium and Shigella flexneri.",
"Functional analysis of the Salmonella typhimurium invasion genes invl and invJ and identification of a target of the protein secretion apparatus encoded in the inv locus.",
"Vaccination against en... | [
1993,
1995,
1998,
1997,
1996
] | 5 | [] | [] | 0 | 0 | null | [
"Pseudomonadota"
] | [
583
] | 1 | [] | [] | 0 | true | Family | Salmonella invasion protein InvJ | Salmonella invasion protein InvJ | Invas_InvJ | 6 |
IPR003067 | 3,067 | Plasmodium circumsporozoite protein | Crcmsprzoite | Family | 2,365 | false | false | null | [
"GO:0009986"
] | [
"cell surface"
] | [
"cellular_component"
] | 1 | [
"PRINTS"
] | [
"PR01303"
] | [
"CRCMSPRZOITE"
] | [
2365
] | 1 | [] | [] | [] | 0 | [
"3vdj",
"3vdk",
"3vdl",
"6b0s",
"6mb3",
"6mhg",
"6x87",
"7rxi",
"7rxj",
"7rxl",
"7rxp",
"7s0x",
"7v05",
"8dyw",
"8dyx",
"8dyy",
"8dz3",
"8dz4",
"8dz5",
"8eh5",
"8ek1",
"8eka",
"8oil",
"9hzj",
"9hzk"
] | 25 | [
"PUB00006235",
"PUB00006466",
"PUB00006478",
"PUB00006512"
] | [
"3802196",
"10639441",
"10697892",
"10643909"
] | [
"The circumsporozoite gene of the Plasmodium cynomolgi complex.",
"The cytotoxic T-lymphocyte epitope of the Plasmodium falciparum circumsporozoite protein also modulates the efficiency of receptor-ligand interaction with hepatocytes.",
"Pre-erythrocytic malaria vaccine: mechanisms of protective immunity and hu... | [
1987,
2000,
1999,
2000
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2365
] | 1 | [] | [] | 0 | true | Family | Plasmodium circumsporozoite protein | Plasmodium circumsporozoite protein | Crcmsprzoite | 9 |
IPR003069 | 3,069 | Ecdysteroid receptor | Ecdystd_rcpt | Family | 2,544 | false | false | Steroid or nuclear hormone receptors (NRs) constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions, including control of embryonic development, cell differentiation and homeostasis. Members of the superfamily include the steroid hormone receptors and r... | [
"GO:0003677",
"GO:0004879",
"GO:0035100",
"GO:0006355",
"GO:0035076",
"GO:0005634"
] | [
"DNA binding",
"nuclear receptor activity",
"ecdysone binding",
"regulation of DNA-templated transcription",
"ecdysone receptor signaling pathway",
"nucleus"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 6 | [
"PRINTS"
] | [
"PR01283"
] | [
"ECDYSTEROIDR"
] | [
2544
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-159418",
"R-DME-383280",
"R-DME-4090294",
"R-DME-8866427",
"R-DME-9029569",
"R-DME-9623433"
] | [
"REACTOME:R-DME-159418",
"REACTOME:R-DME-383280",
"REACTOME:R-DME-4090294",
"REACTOME:R-DME-8866427",
"REACTOME:R-DME-9029569",
"REACTOME:R-DME-9623433"
] | 6 | [
"1r1k",
"1r20",
"1z5x",
"2nxx",
"2r40",
"3hc6",
"3ixp",
"4ozr",
"4ozt",
"4umm",
"7bju",
"7bjv"
] | 12 | [
"PUB00004464",
"PUB00006168",
"PUB00006288",
"PUB00006487",
"PUB00015853"
] | [
"7899080",
"8165128",
"8324824",
"7711747",
"14747695"
] | [
"Vitamin D receptor contains multiple dimerization interfaces that are functionally different.",
"Human androgen receptor expressed in HeLa cells activates transcription in vitro.",
"Drosophila tissues with different metamorphic responses to ecdysone express different ecdysone receptor isoforms.",
"Mosquito e... | [
1995,
1994,
1993,
1995,
2004
] | 5 | [
"IPR001723"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
2544
] | 1 | [
"Danio rerio",
"Drosophila melanogaster"
] | [
2,
3
] | 2 | true | Family | Ecdysteroid receptor | Ecdysteroid receptor | Ecdystd_rcpt | 4 |
IPR003070 | 3,070 | Nuclear receptor subfamily 4 group A member 1-3 | NR4A1-3 | Family | 4,884 | false | false | This family groups members of the steroid receptor superfamily, the nuclear receptor subfamily 4 group A members 1-3 (NR4A1-3) also known as NGFI-B/Nur77 [ , ], Nurr1 (Nur-related factor 1) [ ] and NOR-1 (neuron derived orphan receptor) [ ], respectively. The NR4A3/NOR-1 binds to the B1a response-element, which has bee... | [
"GO:0003677",
"GO:0004879",
"GO:0006355",
"GO:0005634"
] | [
"DNA binding",
"nuclear receptor activity",
"regulation of DNA-templated transcription",
"nucleus"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"PRINTS"
] | [
"PR01284"
] | [
"NUCLEARECPTR"
] | [
4884
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-383280",
"R-CFA-383280",
"R-HSA-198693",
"R-HSA-383280",
"R-HSA-4090294",
"R-HSA-5674400",
"R-HSA-8936459",
"R-MMU-198693",
"R-MMU-383280",
"R-RNO-198693",
"R-RNO-383280",
"R-XTR-383280"
] | [
"REACTOME:R-BTA-383280",
"REACTOME:R-CFA-383280",
"REACTOME:R-HSA-198693",
"REACTOME:R-HSA-383280",
"REACTOME:R-HSA-4090294",
"REACTOME:R-HSA-5674400",
"REACTOME:R-HSA-8936459",
"REACTOME:R-MMU-198693",
"REACTOME:R-MMU-383280",
"REACTOME:R-RNO-198693",
"REACTOME:R-RNO-383280",
"REACTOME:R-XTR-... | 12 | [
"1ovl",
"1pdu",
"1yje",
"2qw4",
"3v3e",
"3v3q",
"4jgv",
"4kzi",
"4kzj",
"4kzm",
"4re8",
"4ree",
"4ref",
"4rze",
"4rzf",
"4rzg",
"4whf",
"4whg",
"5y41",
"5yd6",
"6dda",
"6kz5",
"7wnh",
"8cyo",
"8wuy",
"8xtt",
"8y7l",
"8z5a"
] | 28 | [
"PUB00004464",
"PUB00006168",
"PUB00006275",
"PUB00006342",
"PUB00006550",
"PUB00006579",
"PUB00015853",
"PUB00032659",
"PUB00151509",
"PUB00151510"
] | [
"7899080",
"8165128",
"1314418",
"8570200",
"1491694",
"7811288",
"14747695",
"15716272",
"37001519",
"17184956"
] | [
"Vitamin D receptor contains multiple dimerization interfaces that are functionally different.",
"Human androgen receptor expressed in HeLa cells activates transcription in vitro.",
"Participation of non-zinc finger residues in DNA binding by two nuclear orphan receptors.",
"Fusion of the EWS gene to CHN, a m... | [
1995,
1994,
1992,
1996,
1992,
1994,
2004,
2005,
2023,
2007
] | 10 | [
"IPR001723"
] | [
"IPR003071",
"IPR003072",
"IPR003073"
] | 1 | 3 | 0 | [
"Eumetazoa"
] | [
4884
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
17,
24,
13,
16
] | 4 | true | Family | Nuclear receptor subfamily 4 group A member 1-3 | Nuclear receptor subfamily 4 group A member 1-3 | NR4A1-3 | 7 |
IPR003071 | 3,071 | Nuclear receptor subfamily 4 group A member 1 | NR4A1 | Family | 608 | false | false | This entry includes nuclear receptor subfamily 4 group A member 1 (NR4A1, also known as NUR77 and HMR-type), an early response protein and orphan member of the steroid hormone receptor superfamily [ ]. It binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' [ ]. It is expressed in the lung, brain and superior cervic... | [
"GO:0003677",
"GO:0004879",
"GO:0006355",
"GO:0005634"
] | [
"DNA binding",
"nuclear receptor activity",
"regulation of DNA-templated transcription",
"nucleus"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"PRINTS"
] | [
"PR01285"
] | [
"HMRNUCRECPTR"
] | [
608
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-383280",
"R-CFA-383280",
"R-HSA-198693",
"R-HSA-383280",
"R-HSA-5674400",
"R-MMU-198693",
"R-MMU-383280",
"R-RNO-198693",
"R-RNO-383280"
] | [
"REACTOME:R-BTA-383280",
"REACTOME:R-CFA-383280",
"REACTOME:R-HSA-198693",
"REACTOME:R-HSA-383280",
"REACTOME:R-HSA-5674400",
"REACTOME:R-MMU-198693",
"REACTOME:R-MMU-383280",
"REACTOME:R-RNO-198693",
"REACTOME:R-RNO-383280"
] | 9 | [
"1yje",
"2qw4",
"3v3e",
"3v3q",
"4jgv",
"4kzi",
"4kzj",
"4kzm",
"4re8",
"4ree",
"4ref",
"4rze",
"4rzf",
"4rzg",
"4whf",
"4whg",
"6kz5",
"8wuy",
"8z5a"
] | 19 | [
"PUB00004464",
"PUB00006168",
"PUB00006275",
"PUB00015853",
"PUB00151507",
"PUB00151508",
"PUB00151509"
] | [
"7899080",
"8165128",
"1314418",
"14747695",
"15466594",
"22983157",
"37001519"
] | [
"Vitamin D receptor contains multiple dimerization interfaces that are functionally different.",
"Human androgen receptor expressed in HeLa cells activates transcription in vitro.",
"Participation of non-zinc finger residues in DNA binding by two nuclear orphan receptors.",
"Nuclear receptors: the evolution o... | [
1995,
1994,
1992,
2004,
2004,
2012,
2023
] | 7 | [
"IPR003070"
] | [] | 1 | 0 | 1 | [
"Bacillati",
"Eukaryota"
] | [
2,
606
] | 2 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
4,
3
] | 3 | true | Family | Nuclear receptor subfamily 4 group A member 1 | Nuclear receptor subfamily 4 group A member 1 | NR4A1 | 6 |
IPR003072 | 3,072 | Nuclear receptor subfamily 4 group A member 3 | NR4A3 | Family | 666 | false | false | Human Nuclear receptor subfamily 4 group A member 3 (also known as NOR-1) mRNA has been detected in adult heart and skeletal muscle, as well as in foetal brain, indicating that its expression is not restricted to events that occur during neural development [ ]; it plays a role in the regulation of proliferation, surviv... | [
"GO:0003677",
"GO:0004879",
"GO:0006355",
"GO:0005634"
] | [
"DNA binding",
"nuclear receptor activity",
"regulation of DNA-templated transcription",
"nucleus"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"PRINTS"
] | [
"PR01286"
] | [
"NORNUCRECPTR"
] | [
666
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-383280",
"R-HSA-8936459",
"R-MMU-383280",
"R-RNO-383280"
] | [
"REACTOME:R-HSA-383280",
"REACTOME:R-HSA-8936459",
"REACTOME:R-MMU-383280",
"REACTOME:R-RNO-383280"
] | 4 | [
"8xtt"
] | 1 | [
"PUB00004464",
"PUB00006168",
"PUB00006342",
"PUB00006355",
"PUB00015853",
"PUB00151511",
"PUB00151512"
] | [
"7899080",
"8165128",
"8570200",
"8809112",
"14747695",
"12709428",
"21868379"
] | [
"Vitamin D receptor contains multiple dimerization interfaces that are functionally different.",
"Human androgen receptor expressed in HeLa cells activates transcription in vitro.",
"Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma.",
"... | [
1995,
1994,
1996,
1996,
2004,
2003,
2011
] | 7 | [
"IPR003070"
] | [] | 1 | 0 | 1 | [
"Eukaryota",
"Mycobacterium asiaticum",
"freshwater metagenome"
] | [
664,
1,
1
] | 3 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
5,
4
] | 3 | true | Family | Nuclear receptor subfamily 4 group A member 3 | Nuclear receptor subfamily 4 group A member 3 | NR4A3 | 5 |
IPR003073 | 3,073 | Nuclear receptor subfamily 4 group A member 2 | NR4A2 | Family | 1,522 | false | false | Nuclear receptor subfamily 4 group A member 2, also known as Nurr1 is a transcriptional regulator important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development [ , ] and it is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are ... | [
"GO:0003677",
"GO:0004879",
"GO:0006355",
"GO:0005634"
] | [
"DNA binding",
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"nucleus"
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"molecular_function",
"biological_process",
"cellular_component"
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"PRINTS"
] | [
"PR01287"
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"NURRNUCRCPTR"
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1522
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"REACTOME:R-RNO-383280",
"REACTOME:R-XTR-383280"
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"1ovl",
"5y41",
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"6dda",
"7wnh",
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] | 6 | [
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"Human androgen receptor expressed in HeLa cells activates transcription in vitro.",
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1995,
1994,
1997,
1992,
2004,
2005,
2007,
2009
] | 8 | [
"IPR003070"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
1522
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
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14,
15,
4,
9
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IPR003074 | 3,074 | Peroxisome proliferator-activated receptor | 1Cnucl_rcpt | Family | 4,002 | false | false | Steroid or nuclear hormone receptors (NRs) constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions, including control of embryonic development, cell differentiation and homeostasis. Members of the superfamily include the steroid hormone receptors and r... | [
"GO:0003677",
"GO:0004879",
"GO:0006355",
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4002
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"REACTOME:R-HSA-2426168",
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1995,
1994,
1992,
1993,
2004
] | 5 | [
"IPR001723"
] | [
"IPR003075",
"IPR003076",
"IPR003077"
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"Vertebrata"
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4002
] | 1 | [
"Danio rerio",
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27,
22,
17,
12
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IPR003075 | 3,075 | Peroxisome proliferator-activated receptor, beta | 1Cnucl_rcpt_B | Family | 1,097 | false | false | Steroid or nuclear hormone receptors (NRs) constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions, including control of embryonic development, cell differentiation and homeostasis. Members of the superfamily include the steroid hormone receptors and r... | [
"GO:0003677",
"GO:0004879",
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1097
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"Xenopus peroxisome prolife... | [
1995,
1994,
1992,
1993,
1994,
2004
] | 6 | [
"IPR003074"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
1097
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
5,
6
] | 4 | true | Family | Peroxisome proliferator-activated receptor, beta | Peroxisome proliferator-activated receptor, beta | 1Cnucl_rcpt_B | 7 |
IPR003077 | 3,077 | Peroxisome proliferator-activated receptor gamma | PPAR-gamma | Family | 1,062 | false | false | Peroxisome proliferator-activated receptors (PPAR) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. Three subtypes of this receptor have been discovered: PPAR alpha, beta and gamma [ ]. They control a variety of target genes involved in lipid homeostasis, diabetes and ... | [
"GO:0003677",
"GO:0004879",
"GO:0006355",
"GO:0005634"
] | [
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"regulation of DNA-templated transcription",
"nucleus"
] | [
"molecular_function",
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"biological_process",
"cellular_component"
] | 4 | [
"PRINTS"
] | [
"PR01291"
] | [
"PROXISOMPAGR"
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1062
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"REACTOME:R-HSA-9841922",
"REACTOME:R-HSA-9844594",
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"Vitamin D receptor contains multiple dimerization interfaces that are functionally different.",
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"Xenopus peroxisome proliferator activated receptors: genomic organization, response element recognition, heterodimer formation wi... | [
1995,
1994,
1993,
1996,
2004,
2007
] | 6 | [
"IPR003074"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
1062
] | 1 | [
"Danio rerio",
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"Mus musculus",
"Rattus norvegicus"
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1,
23,
10,
3
] | 4 | true | Family | Peroxisome proliferator-activated receptor gamma | Peroxisome proliferator-activated receptor gamma | PPAR-gamma | 7 |
IPR003078 | 3,078 | Retinoic acid receptor | Retinoic_acid_rcpt | Family | 5,519 | false | false | Steroid or nuclear hormone receptors (NRs) constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions, including control of embryonic development, cell differentiation and homeostasis. Members of the superfamily include the steroid hormone receptors and r... | [
"GO:0003677",
"GO:0004879",
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"biological_process",
"cellular_component"
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"PRINTS"
] | [
"PR01292"
] | [
"RETNOICACIDR"
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5519
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"Crysta... | [
1995,
1994,
1989,
1991,
1995,
2004
] | 6 | [
"IPR001723"
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"Eumetazoa"
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5519
] | 1 | [
"Danio rerio",
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35,
43,
11,
22
] | 4 | true | Family | Retinoic acid receptor | Retinoic acid receptor | Retinoic_acid_rcpt | 5 |
IPR003079 | 3,079 | Nuclear receptor ROR | ROR_rcpt | Family | 5,021 | false | false | Steroid or nuclear hormone receptors (NRs) constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions, including control of embryonic development, cell differentiation and homeostasis. Members of the superfamily include the steroid hormone receptors and r... | [
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"GO:0004879",
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"PRINTS"
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"PR01293"
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"RORNUCRECPTR"
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5021
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1995,
1994,
2004,
2015,
2005
] | 5 | [
"IPR001723"
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"Vertebrata"
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5021
] | 1 | [
"Danio rerio",
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14,
21,
10,
12
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IPR003080 | 3,080 | Glutathione S-transferase, alpha class | GST_alpha | Family | 3,300 | false | false | Glutathione S-transferases (GSTs) are soluble proteins with typical molecular masses of around 50kDa, each composed of two polypeptide subunits. GSTs catalyse the transfer of the tripeptide glutathione (gamma-glutamyl-cysteinyl-glycine; GSH) to a co-substrate (R-X) containing a reactive electrophillic centre to form a ... | [
"GO:0004364"
] | [
"glutathione transferase activity"
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"molecular_function"
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"PRINTS"
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"GSTRNSFRASEA"
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3300
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"1xwg",
"1ydk",
"2r3x",
"2r6k",
"2vct"... | 60 | [
"PUB00006302",
"PUB00006568"
] | [
"8143720",
"10527929"
] | [
"X-ray crystal structures of cytosolic glutathione S-transferases. Implications for protein architecture, substrate recognition and catalytic function.",
"The role of tyrosine-9 and the C-terminal helix in the catalytic mechanism of Alpha-class glutathione S-transferases."
] | [
1994,
1999
] | 2 | [
"IPR040079"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
3300
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
13,
13,
29
] | 4 | true | Family | Glutathione S-transferase, alpha class | Glutathione S-transferase, alpha class | GST_alpha | 4 |
IPR003081 | 3,081 | Glutathione S-transferase, Mu class | GST_mu | Family | 2,900 | false | false | Glutathione S-transferases (GSTs) are soluble proteins with typical molecular masses of around 50kDa, each composed of two polypeptide subunits. GSTs catalyse the transfer of the tripeptide glutathione (gamma-glutamyl-cysteinyl-glycine; GSH) to a co-substrate (R-X) containing a reactive electrophillic centre to form a ... | [
"GO:0004364"
] | [
"glutathione transferase activity"
] | [
"molecular_function"
] | 1 | [
"PRINTS"
] | [
"PR01267"
] | [
"GSTRNSFRASEM"
] | [
2900
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.5.1.18",
"PWY-4061",
"PWY-6842",
"PWY-7112",
"PWY-7533",
"R-GGA-156590",
"R-GGA-9026762",
"R-GGA-9748787",
"R-GGA-9753281",
"R-HSA-156590",
"R-HSA-9026762",
"R-HSA-9748787",
"R-HSA-9753281",
"R-MMU-156590",
"R-MMU-9026762",
"R-MMU-9748787",
"R-MMU-9753281",
"R-RNO-156590",
"R-... | [
"EC:2.5.1.18",
"METACYC:PWY-4061",
"METACYC:PWY-6842",
"METACYC:PWY-7112",
"METACYC:PWY-7533",
"REACTOME:R-GGA-156590",
"REACTOME:R-GGA-9026762",
"REACTOME:R-GGA-9748787",
"REACTOME:R-GGA-9753281",
"REACTOME:R-HSA-156590",
"REACTOME:R-HSA-9026762",
"REACTOME:R-HSA-9748787",
"REACTOME:R-HSA-9... | 21 | [
"1b4p",
"1c72",
"1gsb",
"1gsc",
"1gsu",
"1gtu",
"1hna",
"1hnb",
"1hnc",
"1mtc",
"1xw5",
"1xw6",
"1xwk",
"1yj6",
"1ykc",
"2ab6",
"2c4j",
"2dc5",
"2f3m",
"2fhe",
"2gst",
"2gtu",
"3fyg",
"3gst",
"3gtu",
"3gur",
"4gst",
"4gtu",
"4q5q",
"5an1",
"5fwg",
"5gst"... | 49 | [
"PUB00006281",
"PUB00006302",
"PUB00006437"
] | [
"8473333",
"8143720",
"10080890"
] | [
"A basis for differentiating among the multiple human Mu-glutathione S-transferases and molecular cloning of brain GSTM5.",
"X-ray crystal structures of cytosolic glutathione S-transferases. Implications for protein architecture, substrate recognition and catalytic function.",
"Evolution of differential substra... | [
1993,
1994,
1999
] | 3 | [
"IPR040079"
] | [] | 1 | 0 | 1 | [
"Eukaryota",
"bird metagenome"
] | [
2898,
2
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
30,
22,
28
] | 4 | true | Family | Glutathione S-transferase, Mu class | Glutathione S-transferase, Mu class | GST_mu | 3 |
IPR003082 | 3,082 | Glutathione S-transferase, Pi class | GST_pi | Family | 1,055 | false | false | Glutathione S-transferases (GSTs) are soluble proteins with typical molecular masses of around 50kDa, each composed of two polypeptide subunits. GSTs catalyse the transfer of the tripeptide glutathione (gamma-glutamyl-cysteinyl-glycine; GSH) to a co-substrate (R-X) containing a reactive electrophillic centre to form a ... | [
"GO:0004364"
] | [
"glutathione transferase activity"
] | [
"molecular_function"
] | 1 | [
"PRINTS"
] | [
"PR01268"
] | [
"GSTRNSFRASEP"
] | [
1055
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.5.1.18",
"PWY-4061",
"PWY-6842",
"PWY-7112",
"PWY-7533",
"R-CEL-156590",
"R-CEL-3299685",
"R-CEL-6798695",
"R-CEL-9753281",
"R-HSA-156590",
"R-HSA-3299685",
"R-HSA-6798695",
"R-HSA-9753281",
"R-MMU-156590",
"R-MMU-3299685",
"R-MMU-6798695",
"R-MMU-9753281",
"R-RNO-156590",
"R-... | [
"EC:2.5.1.18",
"METACYC:PWY-4061",
"METACYC:PWY-6842",
"METACYC:PWY-7112",
"METACYC:PWY-7533",
"REACTOME:R-CEL-156590",
"REACTOME:R-CEL-3299685",
"REACTOME:R-CEL-6798695",
"REACTOME:R-CEL-9753281",
"REACTOME:R-HSA-156590",
"REACTOME:R-HSA-3299685",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-9... | 21 | [
"10gs",
"11gs",
"12gs",
"13gs",
"14gs",
"16gs",
"17gs",
"18gs",
"19gs",
"1aqv",
"1aqw",
"1aqx",
"1bay",
"1eog",
"1eoh",
"1glp",
"1glq",
"1gss",
"1gsy",
"1gti",
"1kbn",
"1lbk",
"1md3",
"1md4",
"1pgt",
"1px6",
"1px7",
"1tu7",
"1tu8",
"1zgn",
"20gs",
"22gs"... | 83 | [
"PUB00006405",
"PUB00006425",
"PUB00006568"
] | [
"9560266",
"9813167",
"10527929"
] | [
"Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases.",
"Shifting substrate specificity of human glutathione transferase (from class Pi to class alpha) by a single point mutation.",
"The role of tyrosine-9 and the C-terminal helix in the catalytic mechanism of Alpha-class glutathion... | [
1998,
1998,
1999
] | 3 | [
"IPR040079"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
1055
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
5,
9,
6
] | 5 | true | Family | Glutathione S-transferase, Pi class | Glutathione S-transferase, Pi class | GST_pi | 1 |
IPR003083 | 3,083 | S-crystallin | S-crystallin | Family | 106 | false | false | S-crystallins of cephalopod are the major protein constituent of the lens in cephalopods. Their primary protein sequences show a high degree (41%) of identity with the cephalopod digestive gland sigma-class glutathione transferase (GST). In spite of the sequence similarity, lens S-crystallin shows little if any GST act... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR01269"
] | [
"SCRYSTALLIN"
] | [
106
] | 1 | [] | [] | [] | 0 | [
"1gsq",
"2gsq",
"5b7c"
] | 3 | [
"PUB00006320",
"PUB00006357",
"PUB00006499",
"PUB00043616"
] | [
"7727393",
"8827456",
"9929473",
"8440736"
] | [
"Three-dimensional structure, catalytic properties, and evolution of a sigma class glutathione transferase from squid, a progenitor of the lens S-crystallins of cephalopods.",
"Kinetic characterization of the endogenous glutathione transferase activity of octopus lens S-crystallin.",
"Homology modeling of cepha... | [
1995,
1996,
1999,
1993
] | 4 | [
"IPR040079"
] | [] | 1 | 0 | 1 | [
"Eumetazoa"
] | [
106
] | 1 | [] | [] | 0 | true | Family | S-crystallin | S-crystallin | S-crystallin | 5 |
IPR003084 | 3,084 | Class I/II Histone deacetylase HDAC | HDAC_I/II | Family | 16,610 | false | false | This entry includes Class I and Class II histone deacetylases (HDACs). Histone deacetylases (HDACs) are a class of enzymes that remove acetyl groups from N(6)-acetyl-lysine residues on histones. This process plays a critical role in transcription regulation, as HDACs facilitate tighter wrapping of DNA around histones. ... | [
"GO:0004407"
] | [
"histone deacetylase activity"
] | [
"molecular_function"
] | 1 | [
"PIRSF",
"PRINTS"
] | [
"PIRSF037913",
"PR01271"
] | [
"His_deacetylse_1",
"HISDACETLASE"
] | [
11655,
16295
] | 2 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.5.1.98",
"R-BTA-1538133",
"R-BTA-201722",
"R-BTA-2173795",
"R-BTA-3214815",
"R-BTA-350054",
"R-BTA-3769402",
"R-BTA-4551638",
"R-BTA-6804758",
"R-BTA-73762",
"R-BTA-8936459",
"R-BTA-8943724",
"R-BTA-9018519",
"R-BTA-9022692",
"R-BTA-9701898",
"R-BTA-9764725",
"R-BTA-9824594",
"R... | [
"EC:3.5.1.98",
"REACTOME:R-BTA-1538133",
"REACTOME:R-BTA-201722",
"REACTOME:R-BTA-2173795",
"REACTOME:R-BTA-3214815",
"REACTOME:R-BTA-350054",
"REACTOME:R-BTA-3769402",
"REACTOME:R-BTA-4551638",
"REACTOME:R-BTA-6804758",
"REACTOME:R-BTA-73762",
"REACTOME:R-BTA-8936459",
"REACTOME:R-BTA-8943724... | 180 | [
"1t64",
"1t67",
"1t69",
"1vkg",
"1w22",
"2v5w",
"2v5x",
"3ew8",
"3ewf",
"3ezp",
"3ezt",
"3f06",
"3f07",
"3f0r",
"3max",
"3mz3",
"3mz4",
"3mz6",
"3mz7",
"3rqd",
"3sff",
"3sfh",
"4a69",
"4bkx",
"4lxz",
"4ly1",
"4qa0",
"4qa1",
"4qa2",
"4qa3",
"4qa4",
"4qa5"... | 141 | [
"PUB00004480",
"PUB00006434",
"PUB00006504",
"PUB00006562",
"PUB00160366"
] | [
"9278492",
"10072350",
"10322454",
"10322142",
"38822399"
] | [
"Histone deacetylases, acetoin utilization proteins and acetylpolyamine amidohydrolases are members of an ancient protein superfamily.",
"Histone acetylases and deacetylases in cell proliferation.",
"Histone deacetylases: transcriptional repression with SINers and NuRDs.",
"Histone acetylation and cancer.",
... | [
1997,
1999,
1999,
1999,
2024
] | 5 | [
"IPR000286"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
94,
331,
16161,
24
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
21,
3,
8,
4,
55,
13,
2,
29,
23,
2,
2,
46
] | 12 | true | Family | Class I/II Histone deacetylase HDAC | Class I/II Histone deacetylase HDAC | HDAC_I/II | 3 |
IPR003085 | 3,085 | Acetoin utilization protein AcuC | AcuC | Family | 5,396 | false | false | Acetoin utilisation proteins (ACUC) are found in eubacteria and acetylpolyamine amidohydrolases APHAs occur in archaeal bacteria, eubacteria, and some eukaryotic organisms [ ]. HDAs may have evolved at least twice from APHAs, the more recent gene duplication event resembling APHAs more closely [ ]. Disrupting the expre... | [
"GO:0045149"
] | [
"acetoin metabolic process"
] | [
"biological_process"
] | 1 | [
"PRINTS",
"CDD"
] | [
"PR01272",
"cd09994"
] | [
"ACUCPROTEIN",
"HDAC_AcuC_like"
] | [
4170,
5356
] | 2 | [] | [] | [] | 0 | [
"1c3p",
"1c3r",
"1c3s"
] | 3 | [
"PUB00004480",
"PUB00160366"
] | [
"9278492",
"38822399"
] | [
"Histone deacetylases, acetoin utilization proteins and acetylpolyamine amidohydrolases are members of an ancient protein superfamily.",
"Advances in targeting histone deacetylase for treatment of solid tumors."
] | [
1997,
2024
] | 2 | [
"IPR000286"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
90,
5257,
6,
43
] | 4 | [] | [] | 0 | true | Family | Acetoin utilization protein AcuC | Acetoin utilization protein AcuC | AcuC | 4 |
IPR003087 | 3,087 | Neutrophil gelatinase-associated lipocalin/epididymal-specific lipocalin-12 | LCN2/LCN12 | Family | 530 | false | false | Murine neutrophil gelatinase-associated lipocalin precursor (NGAL) exhibits a 7-10-fold increase in expression in cultured mouse kidney cells infected by Simian virus 40 (SV40) or other viruses [ ]. NGAL has been identified as a major secretory product of lipopolysaccharide-stimulated cultured mouse macrophages, sugges... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR01275"
] | [
"NGELATINASE"
] | [
530
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6785807",
"R-HSA-6798695",
"R-HSA-6799990",
"R-HSA-917937",
"R-MMU-6798695",
"R-MMU-6799990",
"R-MMU-804914",
"R-MMU-917937",
"R-RNO-6798695",
"R-RNO-6799990",
"R-RNO-804914",
"R-RNO-917937"
] | [
"REACTOME:R-HSA-6785807",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-6799990",
"REACTOME:R-HSA-917937",
"REACTOME:R-MMU-6798695",
"REACTOME:R-MMU-6799990",
"REACTOME:R-MMU-804914",
"REACTOME:R-MMU-917937",
"REACTOME:R-RNO-6798695",
"REACTOME:R-RNO-6799990",
"REACTOME:R-RNO-804914",
"REACTOME:R-... | 12 | [
"1dfv",
"1l6m",
"1ngl",
"1qqs",
"1x71",
"1x89",
"1x8u",
"2k23",
"2l5p",
"3bx7",
"3bx8",
"3by0",
"3cbc",
"3cmp",
"3dsz",
"3dtq",
"3fw4",
"3fw5",
"3hwd",
"3hwe",
"3hwf",
"3hwg",
"3i0a",
"3k3l",
"3pec",
"3ped",
"3s26",
"3sao",
"3t1d",
"3tf6",
"3tzs",
"3u0d"... | 67 | [
"PUB00006330",
"PUB00006348",
"PUB00006483",
"PUB00006489",
"PUB00006549"
] | [
"7545679",
"8666241",
"8335946",
"7544071",
"1281792"
] | [
"Identification of a new acute phase protein.",
"An apparent autocrine mechanism amplifies the dexamethasone- and retinoic acid-induced expression of mouse lipocalin-encoding gene 24p3.",
"Identification by microsequencing of lipopolysaccharide-induced proteins secreted by mouse macrophages.",
"An increase in... | [
1995,
1996,
1993,
1995,
1992
] | 5 | [
"IPR002345"
] | [] | 1 | 0 | 1 | [
"Gnathostomata",
"Limosilactobacillus urinaemulieris"
] | [
528,
2
] | 2 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
6,
6
] | 3 | true | Family | Neutrophil gelatinase-associated lipocalin/epididymal-specific lipocalin-12 | Neutrophil gelatinase-associated lipocalin/epididymal-specific lipocalin-12 | LCN2/LCN12 | 1 |
IPR003090 | 3,090 | Alpha-crystallin, N-terminal | Alpha-crystallin_N | Domain | 3,056 | false | false | The crystallins are water-soluble structural proteins that occur in high concentration in the cytoplasm of eye lens fibre cells. Four major groups of crystallin have been distinguished on the basis of size, charge and immunological properties: alpha-, beta-and gamma-crystallins occur in all vertebrate classes (though g... | [
"GO:0005212"
] | [
"structural constituent of eye lens"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF00525"
] | [
"Crystallin"
] | [
3056
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-3371571",
"R-GGA-3371571",
"R-HSA-3371571",
"R-MMU-3371571",
"R-RNO-3371571",
"R-SSC-3371571"
] | [
"REACTOME:R-BTA-3371571",
"REACTOME:R-GGA-3371571",
"REACTOME:R-HSA-3371571",
"REACTOME:R-MMU-3371571",
"REACTOME:R-RNO-3371571",
"REACTOME:R-SSC-3371571"
] | 6 | [
"2klr",
"2ygd",
"3j07",
"5ltw",
"6f2r",
"6t1r",
"9u4l"
] | 7 | [
"PUB00003917",
"PUB00005345",
"PUB00034659",
"PUB00034662",
"PUB00034663"
] | [
"7634077",
"2688200",
"15575808",
"9650080",
"11278766"
] | [
"The structure of avian eye lens delta-crystallin reveals a new fold for a superfamily of oligomeric enzymes.",
"Evolution of eye lens crystallins: the stress connection.",
"alpha-crystallin: a review of its structure and function.",
"alpha-Crystallin polymers and polymerization: the view from down under.",
... | [
1994,
1989,
2004,
1998,
2001
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Bilateria"
] | [
4,
3052
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
20,
10,
12
] | 4 | true | Domain | Alpha-crystallin, N-terminal | Alpha-crystallin, N-terminal | Alpha-crystallin_N | 5 |
IPR003092 | 3,092 | Two pore domain potassium channel, TASK family | 2pore_dom_K_chnl_TASK | Family | 8,620 | false | false | 2P-domain channels influence the resting membrane potential and as a result can control cell excitability. In addition, they pass K+ in response to changes in membrane potential, and are also tightly regulated by molecular oxygen, GABA (gamma-aminobutyric acid), noradrenaline and serotonin. The first member of this fam... | [
"GO:0005267",
"GO:0071805",
"GO:0016020"
] | [
"potassium channel activity",
"potassium ion transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PIRSF",
"PRINTS"
] | [
"PIRSF038061",
"PR01095"
] | [
"K_channel_subfamily_K_type",
"TASKCHANNEL"
] | [
4169,
7036
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-1299308",
"R-BTA-5576886",
"R-CEL-1299316",
"R-CEL-5576886",
"R-HSA-1299308",
"R-HSA-1299316",
"R-HSA-1299361",
"R-HSA-5576886",
"R-MMU-1299308",
"R-MMU-1299316",
"R-MMU-1299344",
"R-MMU-1299361",
"R-MMU-5576886",
"R-RNO-1299308",
"R-RNO-1299316",
"R-RNO-1299344",
"R-RNO-55768... | [
"REACTOME:R-BTA-1299308",
"REACTOME:R-BTA-5576886",
"REACTOME:R-CEL-1299316",
"REACTOME:R-CEL-5576886",
"REACTOME:R-HSA-1299308",
"REACTOME:R-HSA-1299316",
"REACTOME:R-HSA-1299361",
"REACTOME:R-HSA-5576886",
"REACTOME:R-MMU-1299308",
"REACTOME:R-MMU-1299316",
"REACTOME:R-MMU-1299344",
"REACTOM... | 17 | [
"3ukm",
"6rv2",
"6rv3",
"6rv4",
"6wlv",
"6wm0",
"7sk0",
"7sk1",
"8k1j",
"8k1q",
"8k1v",
"8k1z",
"9g9v",
"9g9w",
"9g9x",
"9mek",
"9mel"
] | 17 | [
"PUB00001278",
"PUB00001298",
"PUB00001308",
"PUB00004219",
"PUB00004878"
] | [
"8605869",
"9003761",
"9312005",
"7651518",
"8917578"
] | [
"TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure.",
"Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel.",
"TASK, a human background K+ channel to sense external pH variations near physiological pH.",
"A new family... | [
1996,
1996,
1997,
1995,
1996
] | 5 | [
"IPR003280"
] | [
"IPR005406",
"IPR005407",
"IPR005408",
"IPR008073"
] | 1 | 4 | 0 | [
"Candidatus Fimadaptatus faecigallinarum",
"Metazoa"
] | [
1,
8619
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
21,
14,
5,
17,
19,
23
] | 6 | true | Family | Two pore domain potassium channel, TASK family | Two pore domain potassium channel, TASK family | 2pore_dom_K_chnl_TASK | 3 |
IPR003093 | 3,093 | Apoptosis regulator, Bcl-2 protein, BH4 | Bcl2_BH4 | Domain | 2,673 | false | false | Apoptosis, or programmed cell death (PCD), is a common and evolutionarily conserved property of all metazoans [ ]. In many biological processes, apoptosis is required to eliminate supernumerary or dangerous (such as pre-cancerous) cells and to promote normal development. Dysregulation of apoptosis can, therefore, contr... | [
"GO:0042981"
] | [
"regulation of apoptotic process"
] | [
"biological_process"
] | 1 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF02180",
"PS50063",
"SM00265"
] | [
"BH4",
"BH4_2",
"BH4"
] | [
2155,
2518,
1856
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00829",
"R-CEL-111453",
"R-CEL-9648002",
"R-GGA-111453",
"R-GGA-844455",
"R-GGA-9648002",
"R-HSA-111447",
"R-HSA-111453",
"R-HSA-6785807",
"R-HSA-844455",
"R-HSA-9018519",
"R-HSA-9634638",
"R-HSA-9648002",
"R-HSA-9692913",
"R-HSA-9702518",
"R-HSA-9818030",
"R-HSA-9824594",
"R-... | [
"PROSITEDOC:PDOC00829",
"REACTOME:R-CEL-111453",
"REACTOME:R-CEL-9648002",
"REACTOME:R-GGA-111453",
"REACTOME:R-GGA-844455",
"REACTOME:R-GGA-9648002",
"REACTOME:R-HSA-111447",
"REACTOME:R-HSA-111453",
"REACTOME:R-HSA-6785807",
"REACTOME:R-HSA-844455",
"REACTOME:R-HSA-9018519",
"REACTOME:R-HSA-... | 24 | [
"1af3",
"1bxl",
"1g5j",
"1g5m",
"1gjh",
"1lxl",
"1maz",
"1mk3",
"1o0l",
"1ohu",
"1pq0",
"1pq1",
"1r2d",
"1r2e",
"1r2g",
"1r2h",
"1r2i",
"1ty4",
"1ysg",
"1ysi",
"1ysn",
"1ysw",
"1zy3",
"2a5y",
"2b48",
"2bzw",
"2lp8",
"2lpc",
"2m03",
"2m04",
"2me8",
"2me9"... | 179 | [
"PUB00000008",
"PUB00001030",
"PUB00001926",
"PUB00017281",
"PUB00017291",
"PUB00017301"
] | [
"8910675",
"15335822",
"8918887",
"11341280",
"9735050",
"12631689"
] | [
"Structure-function analysis of Bcl-2 family proteins. Regulators of programmed cell death.",
"A boom time for necrobiology.",
"BID: a novel BH3 domain-only death agonist.",
"Apoptosis. Death of a monopoly?",
"The Bcl-2 protein family: arbiters of cell survival.",
"Cellular distribution of Bcl-2 family pr... | [
1996,
1993,
1996,
2001,
1998,
2003
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Natranaeroarchaeum aerophilus",
"Vespertilionid gammaherpesvirus 1",
"ecological metagenomes"
] | [
65,
2604,
1,
1,
2
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
5,
24,
14,
23
] | 5 | true | Domain | Apoptosis regulator, Bcl-2 protein, BH4 | Apoptosis regulator, Bcl-2 protein, BH4 | Bcl2_BH4 | 7 |
IPR003094 | 3,094 | Fructose-2,6-bisphosphatase | 6Pfruct_kin | Family | 20,316 | false | false | 6-Phosphofructo-2-kinase ( , ) is a bifunctional enzyme that catalyses both the synthesis and the degradation of fructose-2, 6-bisphosphate. The fructose-2,6-bisphosphatase reaction involves a phosphohistidine intermediate. The catalytic pathway is: ATP + D-fructose 6-phosphate = ADP + D-fructose 2,6-bisphosphate D-fru... | [
"GO:0003824",
"GO:0005524",
"GO:0006003"
] | [
"catalytic activity",
"ATP binding",
"fructose 2,6-bisphosphate metabolic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PRINTS",
"PANTHER"
] | [
"PR00991",
"PTHR10606"
] | [
"6PFRUCTKNASE",
""
] | [
18748,
19470
] | 2 | [
"EC",
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.1.105",
"3.1.3.46",
"R-BTA-9634600",
"R-CEL-9634600",
"R-GGA-352875",
"R-GGA-352882",
"R-HSA-163358",
"R-HSA-163767",
"R-HSA-9634600",
"R-MMU-9634600",
"R-RNO-9634600",
"R-SCE-9634600",
"R-SPO-9634600"
] | [
"EC:2.7.1.105",
"EC:3.1.3.46",
"REACTOME:R-BTA-9634600",
"REACTOME:R-CEL-9634600",
"REACTOME:R-GGA-352875",
"REACTOME:R-GGA-352882",
"REACTOME:R-HSA-163358",
"REACTOME:R-HSA-163767",
"REACTOME:R-HSA-9634600",
"REACTOME:R-MMU-9634600",
"REACTOME:R-RNO-9634600",
"REACTOME:R-SCE-9634600",
"REAC... | 13 | [
"1bif",
"1c7z",
"1c80",
"1c81",
"1fbt",
"1k6m",
"1tip",
"2axn",
"2bif",
"2dwo",
"2dwp",
"2i1v",
"3bif",
"3qpu",
"3qpv",
"3qpw",
"4d4j",
"4d4k",
"4d4l",
"4d4m",
"4ma4",
"5ajv",
"5ajw",
"5ajx",
"5ajy",
"5ajz",
"5ak0",
"5hr5",
"5htk",
"6etj",
"6hvh",
"6hvi"... | 37 | [
"PUB00000264",
"PUB00001475"
] | [
"9753654",
"9652401"
] | [
"An essential methionine residue involved in substrate binding by phosphofructokinases.",
"Sequence and structure of the human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase heart isoform gene (PFKFB2)."
] | [
1998,
1998
] | 2 | [
"IPR013078"
] | [
"IPR014379"
] | 1 | 1 | 0 | [
"Archaea",
"Bacteria",
"Dasosvirus sp.",
"Eukaryota",
"metagenomes"
] | [
3,
879,
1,
19402,
31
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
3,
27,
5,
32,
33,
4,
11,
42,
4,
4,
19
] | 12 | true | Family | Fructose-2,6-bisphosphatase | Fructose-2,6-bisphosphatase | 6Pfruct_kin | 2 |
IPR003096 | 3,096 | Smooth muscle protein/calponin | SM22_calponin | Family | 15,506 | false | false | Calponin is a smooth muscle-specific, actin-, tropomyosin- and calmodulin-binding protein believed to be involved in regulation or modulation of contraction [ ]; interaction of the protein with actin inhibits actomyosin MgATPase activity. Multiple isoforms are found in smooth muscle [ ]. Calponin is a basic protein of ... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR00888"
] | [
"SM22CALPONIN"
] | [
15506
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-114604",
"R-BTA-114608",
"R-BTA-1257604",
"R-BTA-1433557",
"R-BTA-193648",
"R-BTA-2029482",
"R-BTA-2871796",
"R-BTA-2871809",
"R-BTA-389359",
"R-BTA-416482",
"R-BTA-4420097",
"R-BTA-512988",
"R-BTA-5218920",
"R-BTA-6798695",
"R-BTA-6811558",
"R-BTA-8980692",
"R-BTA-9013149",
... | [
"REACTOME:R-BTA-114604",
"REACTOME:R-BTA-114608",
"REACTOME:R-BTA-1257604",
"REACTOME:R-BTA-1433557",
"REACTOME:R-BTA-193648",
"REACTOME:R-BTA-2029482",
"REACTOME:R-BTA-2871796",
"REACTOME:R-BTA-2871809",
"REACTOME:R-BTA-389359",
"REACTOME:R-BTA-416482",
"REACTOME:R-BTA-4420097",
"REACTOME:R-B... | 114 | [
"1h67",
"1ujo",
"1wym",
"1wyn",
"1wyp",
"2d86",
"3ky9",
"6nf1"
] | 8 | [
"PUB00001664",
"PUB00002836",
"PUB00002979"
] | [
"8370452",
"8144658",
"8550594"
] | [
"Mammalian calponin. Identification and expression of genetic variants.",
"Cloning and expression of a novel acidic calponin isoform from rat aortic vascular smooth muscle.",
"Developmental pattern of expression and genomic organization of the calponin-h1 gene. A contractile smooth muscle cell marker."
] | [
1993,
1994,
1996
] | 3 | [] | [
"IPR001997",
"IPR029978"
] | 0 | 2 | 0 | [
"Bacteria",
"Eukaryota",
"bird metagenome"
] | [
5,
15500,
1
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
5,
100,
4,
59,
37,
1,
49,
1,
1,
1
] | 10 | true | Family | Smooth muscle protein/calponin | Smooth muscle protein/calponin | SM22_calponin | 8 |
IPR003097 | 3,097 | Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding | CysJ-like_FAD-binding | Domain | 36,655 | false | false | This FAD-binding domain can be found in sulfite reductase [NADPH] flavoprotein alpha-component CysJ, NADPH cytochrome P450 reductase, nitric oxide synthase and methionine synthase reductase. CysJ is a component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide [ ]. The struc... | [
"GO:0016491"
] | [
"oxidoreductase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF00667"
] | [
"FAD_binding_1"
] | [
36655
] | 1 | [
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"GenProp1320",
"GenProp1481",
"R-CEL-156581",
"R-CEL-1614635",
"R-CEL-9759218",
"R-DDI-1222556",
"R-DDI-1474151",
"R-DDI-203615",
"R-DDI-203754",
"R-DDI-392154",
"R-DDI-5218920",
"R-DDI-5578775",
"R-DDI-9009391",
"R-DDI-9033241",
"R-DDI-9856530",
"R-DME-1222556",
"R-DME-1474151",
"... | [
"GP:GenProp1320",
"GP:GenProp1481",
"REACTOME:R-CEL-156581",
"REACTOME:R-CEL-1614635",
"REACTOME:R-CEL-9759218",
"REACTOME:R-DDI-1222556",
"REACTOME:R-DDI-1474151",
"REACTOME:R-DDI-203615",
"REACTOME:R-DDI-203754",
"REACTOME:R-DDI-392154",
"REACTOME:R-DDI-5218920",
"REACTOME:R-DDI-5578775",
... | 94 | [
"1amo",
"1ddg",
"1ddi",
"1f20",
"1j9z",
"1ja0",
"1ja1",
"1tll",
"2bf4",
"2bn4",
"2bpo",
"2qtl",
"2qtz",
"3es9",
"3fjo",
"3ojw",
"3ojx",
"3qe2",
"3qfc",
"3qfr",
"3qfs",
"3qft",
"3wkt",
"4dqk",
"4dql",
"4y7c",
"4y9r",
"4y9u",
"4yaf",
"4yal",
"4yao",
"4yau"... | 58 | [
"PUB00014352",
"PUB00024750"
] | [
"10860732",
"11473123"
] | [
"Four crystal structures of the 60 kDa flavoprotein monomer of the sulfite reductase indicate a disordered flavodoxin-like module.",
"Crystal structure of the FAD/NADPH-binding domain of rat neuronal nitric-oxide synthase. Comparisons with NADPH-cytochrome P450 oxidoreductase."
] | [
2000,
2001
] | 2 | [
"IPR017927"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Methanobacteriati",
"unclassified sequences"
] | [
10058,
26530,
23,
44
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
16,
4,
34,
12,
1,
31,
14,
5,
11,
31,
3,
5,
37
] | 13 | true | Domain | Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding | Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding | CysJ-like_FAD-binding | 2 |
IPR003099 | 3,099 | Prephenate dehydrogenase | Prephen_DH | Domain | 28,258 | false | false | This entry represents prephenate dehydrogenase (PDHG) , an enzyme involved in tyrosine biosynthesis [ ] and related proteins. Three enzymes catalyse the conversion of chorismate to hydroxyphenylpyruvate or pyruvate in the aromatic amino acid biosynthesis pathway. In this pathway, chorismate is a branch point intermedia... | [
"GO:0004665",
"GO:0008977",
"GO:0006571"
] | [
"prephenate dehydrogenase (NADP+) activity",
"prephenate dehydrogenase (NAD+) activity",
"L-tyrosine biosynthetic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PROFILE"
] | [
"PS51176"
] | [
"PDH_ADH"
] | [
28258
] | 1 | [
"EC",
"GP",
"GP",
"GP",
"GP",
"GP",
"METACYC",
"PROSITEDOC"
] | [
"1.3.1.12",
"GenProp1234",
"GenProp1251",
"GenProp1309",
"GenProp1538",
"GenProp1708",
"PWY-7303",
"PDOC51176"
] | [
"EC:1.3.1.12",
"GP:GenProp1234",
"GP:GenProp1251",
"GP:GenProp1309",
"GP:GenProp1538",
"GP:GenProp1708",
"METACYC:PWY-7303",
"PROSITEDOC:PDOC51176"
] | 8 | [
"2f1k",
"2g5c",
"2pv7",
"3b1f",
"3dzb",
"3ggg",
"3ggo",
"3ggp",
"3ktd",
"4wji",
"5t95",
"5t9e",
"5t9f",
"5uyy",
"5whx",
"6u60",
"7mqv"
] | 17 | [
"PUB00061316",
"PUB00066096",
"PUB00070219"
] | [
"21798280",
"20944228",
"19082689"
] | [
"Crystal structure of prephenate dehydrogenase from Streptococcus mutans.",
"The structure of Haemophilus influenzae prephenate dehydrogenase suggests unique features of bifunctional TyrA enzymes.",
"Characterization of a key trifunctional enzyme for aromatic amino acid biosynthesis in Archaeoglobus fulgidus."
... | [
2011,
2010,
2009
] | 3 | [] | [
"IPR046825",
"IPR046826"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
620,
23571,
3480,
587
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
8,
1,
2,
6,
1,
1,
15
] | 7 | true | Domain | Prephenate dehydrogenase | Prephenate dehydrogenase | Prephen_DH | 8 |
IPR003102 | 3,102 | Cyclic AMP-responsive element-binding protein 1-like, pKID | CREB1-like_pKID | Domain | 5,564 | false | false | This entry represents the phosphorylated kinase-inducible domain (pKID) of human Cyclic AMP-responsive element-binding protein 1 (CREB) and similar animal proteins. The nuclear factor CREB activates transcription of target genes in part through direct interactions with the KIX domain of the coactivator CREB binding pro... | [
"GO:0005515",
"GO:0006355"
] | [
"protein binding",
"regulation of DNA-templated transcription"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PROFILE"
] | [
"PF02173",
"PS50953"
] | [
"pKID",
"KID"
] | [
5551,
5536
] | 2 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC50953",
"R-BTA-199920",
"R-CEL-198693",
"R-CEL-199920",
"R-CEL-375165",
"R-CEL-442742",
"R-CEL-881907",
"R-CEL-9031628",
"R-CEL-9634638",
"R-DME-198693",
"R-DME-199920",
"R-DME-375165",
"R-DME-442742",
"R-DME-881907",
"R-DME-9634638",
"R-HSA-111931",
"R-HSA-111932",
"R-HSA-198... | [
"PROSITEDOC:PDOC50953",
"REACTOME:R-BTA-199920",
"REACTOME:R-CEL-198693",
"REACTOME:R-CEL-199920",
"REACTOME:R-CEL-375165",
"REACTOME:R-CEL-442742",
"REACTOME:R-CEL-881907",
"REACTOME:R-CEL-9031628",
"REACTOME:R-CEL-9634638",
"REACTOME:R-DME-198693",
"REACTOME:R-DME-199920",
"REACTOME:R-DME-37... | 56 | [
"1kdx",
"2lxt",
"7tbh"
] | 3 | [
"PUB00006396",
"PUB00103955"
] | [
"9413984",
"23651431"
] | [
"Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions.",
"Allosteric communication in the KIX domain proceeds through dynamic repacking of the hydrophobic core."
] | [
1997,
2013
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pyrinomonas methylaliphatogenes"
] | [
5563,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
10,
6,
22,
35,
22
] | 6 | true | Domain | Cyclic AMP-responsive element-binding protein 1-like, pKID | Cyclic AMP-responsive element-binding protein 1-like, pKID | CREB1-like_pKID | 6 |
IPR003105 | 3,105 | SRA-YDG | SRA_YDG | Domain | 13,176 | false | false | This domain has been termed SRA-YDG, for SET and Ring finger Associated, and because of the conserved YDG motif within the domain. Further characteristics of the domain are the conservation of up to 13 evenly spaced glycine residues and a VRV(I/V)RG motif. The domain is mainly found in plants and animals and in bacteri... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF02182",
"PS51015",
"SM00466"
] | [
"SAD_SRA",
"YDG",
"SRA"
] | [
12844,
12990,
12455
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC51015",
"R-HSA-3899300",
"R-HSA-5334118",
"R-HSA-9821002",
"R-MMU-3899300"
] | [
"PROSITEDOC:PDOC51015",
"REACTOME:R-HSA-3899300",
"REACTOME:R-HSA-5334118",
"REACTOME:R-HSA-9821002",
"REACTOME:R-MMU-3899300"
] | 5 | [
"2oxb",
"2pb7",
"2qqu",
"2qqv",
"2qqw",
"2xqr",
"2zkd",
"2zke",
"2zkf",
"2zkg",
"2zo0",
"2zo1",
"2zo2",
"3bi7",
"3clz",
"3dwh",
"3f8i",
"3f8j",
"3fde",
"3oln",
"3q0b",
"3q0c",
"3q0d",
"3q0f",
"4nj5",
"4pw5",
"4pw6",
"4pw7",
"4qen",
"4qeo",
"4qep",
"4ygi"... | 39 | [
"PUB00006615",
"PUB00015424",
"PUB00015425"
] | [
"9880673",
"14993289",
"11691919"
] | [
"Cloning and mapping of Np95 gene which encodes a novel nuclear protein associated with cell proliferation.",
"Np95 is a histone-binding protein endowed with ubiquitin ligase activity.",
"The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four ... | [
1998,
2004,
2001
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
12,
556,
12598,
10
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
83,
2,
7,
3,
1,
51,
7,
83
] | 8 | true | Domain | SRA-YDG | SRA-YDG | SRA_YDG | 4 |
IPR003106 | 3,106 | Leucine zipper, homeobox-associated | Leu_zip_homeo | Domain | 13,547 | false | false | This region is a plant specific leucine zipper that is always found associated with a homeobox [ ]. | [
"GO:0043565",
"GO:0006355"
] | [
"sequence-specific DNA binding",
"regulation of DNA-templated transcription"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"SMART"
] | [
"PF02183",
"SM00340"
] | [
"HALZ",
"HALZ"
] | [
13217,
5988
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-432722",
"R-HSA-6807878",
"R-HSA-9703465"
] | [
"REACTOME:R-HSA-432722",
"REACTOME:R-HSA-6807878",
"REACTOME:R-HSA-9703465"
] | 3 | [] | 0 | [
"PUB00007988"
] | [
"7915839"
] | [
"Structure of homeobox-leucine zipper genes suggests a model for the evolution of gene families."
] | [
1994
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Fremauxvirus"
] | [
2,
19,
13524,
2
] | 4 | [
"Arabidopsis thaliana",
"Homo sapiens",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
87,
18,
52,
121
] | 4 | true | Domain | Leucine zipper, homeobox-associated | Leucine zipper, homeobox-associated | Leu_zip_homeo | 3 |
IPR003107 | 3,107 | HAT (Half-A-TPR) repeat | HAT | Repeat | 46,103 | false | false | This entry represents the HAT repeat in Pre-mRNA-splicing factor SYF1, CLF1 and related proteins that bind RNA from eukaryotes and prokaryotes . The HAT (Half A TPR) repeat has a repetitive pattern characterised by three aromatic residues with a conserved spacing. They are structurally and sequentially similar to TPRs ... | [
"GO:0006396"
] | [
"RNA processing"
] | [
"biological_process"
] | 1 | [
"PFAM",
"SMART"
] | [
"PF02184",
"SM00386"
] | [
"HAT",
"HAT"
] | [
379,
46096
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-72163",
"R-BTA-72165",
"R-DDI-6781823",
"R-DDI-6782135",
"R-DDI-6782210",
"R-DDI-6791226",
"R-DDI-72163",
"R-DME-6781823",
"R-DME-6782135",
"R-DME-6782210",
"R-DME-6791226",
"R-DME-72163",
"R-DME-72187",
"R-DME-72203",
"R-DME-73856",
"R-DME-77595",
"R-HSA-6781823",
"R-HSA-67... | [
"REACTOME:R-BTA-72163",
"REACTOME:R-BTA-72165",
"REACTOME:R-DDI-6781823",
"REACTOME:R-DDI-6782135",
"REACTOME:R-DDI-6782210",
"REACTOME:R-DDI-6791226",
"REACTOME:R-DDI-72163",
"REACTOME:R-DME-6781823",
"REACTOME:R-DME-6782135",
"REACTOME:R-DME-6782210",
"REACTOME:R-DME-6791226",
"REACTOME:R-DM... | 54 | [
"2fo7",
"2hyz",
"2ond",
"2ooe",
"2uy1",
"3jb9",
"3jcm",
"3jcr",
"4e6h",
"4e85",
"4eba",
"5c9s",
"5ctq",
"5ctr",
"5gan",
"5gap",
"5gm6",
"5gmk",
"5ic8",
"5jjw",
"5jjx",
"5jpz",
"5lj3",
"5lj5",
"5lqw",
"5mps",
"5mq0",
"5mqf",
"5nlg",
"5nrl",
"5o9z",
"5oql"... | 186 | [
"PUB00006399",
"PUB00077955",
"PUB00077956",
"PUB00077957",
"PUB00077958",
"PUB00077959",
"PUB00077960",
"PUB00077962",
"PUB00077963",
"PUB00077964"
] | [
"9478129",
"17178401",
"15994330",
"12509417",
"22451905",
"11549768",
"15918885",
"23874216",
"19515729",
"18725399"
] | [
"The HAT helix, a repetitive motif implicated in RNA processing.",
"The splicing factor crooked neck associates with the RNA-binding protein HOW to control glial cell maturation in Drosophila.",
"The Prp19-associated complex is required for specifying interactions of U5 and U6 with pre-mRNA during spliceosome a... | [
1998,
2006,
2005,
2003,
2012,
2001,
2005,
2013,
2009,
2008
] | 10 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
110,
920,
45054,
19
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
98,
10,
25,
10,
35,
23,
9,
62,
36,
8,
8,
131
] | 12 | true | Repeat | HAT (Half-A-TPR) repeat | HAT (Half-A-TPR) repeat | HAT | 5 |
IPR003108 | 3,108 | GAR domain | GAR_dom | Domain | 15,565 | false | false | The GAR (Gas2-related) domain is common in plakin family members and Gas2 family members. It has been shown to bind to microtubules [ , , ] probably through the flexible, positively charged central β-sheet formed by by five antiparallel β-strands [ ]. | [
"GO:0008017"
] | [
"microtubule binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF02187",
"PS51460",
"SM00243"
] | [
"GAS2",
"GAR",
"GAS2"
] | [
15319,
15426,
13710
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2022090",
"R-HSA-264870",
"R-HSA-446107",
"R-HSA-9013420",
"R-HSA-9013424",
"R-HSA-9696264",
"R-HSA-9696270",
"R-HSA-9696273",
"R-MMU-264870",
"R-MMU-446107",
"R-MMU-9013420",
"R-MMU-9013424",
"R-MMU-9696264",
"R-MMU-9696270",
"R-MMU-9696273"
] | [
"REACTOME:R-HSA-2022090",
"REACTOME:R-HSA-264870",
"REACTOME:R-HSA-446107",
"REACTOME:R-HSA-9013420",
"REACTOME:R-HSA-9013424",
"REACTOME:R-HSA-9696264",
"REACTOME:R-HSA-9696270",
"REACTOME:R-HSA-9696273",
"REACTOME:R-MMU-264870",
"REACTOME:R-MMU-446107",
"REACTOME:R-MMU-9013420",
"REACTOME:R-... | 15 | [
"1v5r",
"5ve9",
"5x57",
"9kbw"
] | 4 | [
"PUB00078917",
"PUB00078918",
"PUB00078919",
"PUB00100814"
] | [
"20335501",
"11112700",
"11854008",
"28541346"
] | [
"The spectraplakin Short stop is an actin-microtubule cross-linker that contributes to organization of the microtubule network.",
"Characterization of the microtubule binding domain of microtubule actin crosslinking factor (MACF): identification of a novel group of microtubule associated proteins.",
"Plakins: a... | [
2010,
2001,
2002,
2017
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
9,
15554,
2
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
10,
104,
25,
40,
33,
1,
33
] | 7 | true | Domain | GAR domain | GAR domain | GAR_dom | 9 |
IPR003110 | 3,110 | Phosphorylated immunoreceptor signalling ITAM | Phos_immunorcpt_sig_ITAM | Repeat | 3,086 | false | false | Phosphorylated immunoreceptor signalling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases [ ]. Motif may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery. | [
"GO:0004888",
"GO:0007166",
"GO:0016020"
] | [
"transmembrane signaling receptor activity",
"cell surface receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF02189",
"PS51055",
"SM00077"
] | [
"ITAM",
"ITAM_1",
"ITAM"
] | [
2026,
2775,
2483
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC51055",
"R-BTA-114604",
"R-BTA-198933",
"R-BTA-202424",
"R-BTA-202427",
"R-BTA-202430",
"R-BTA-202433",
"R-BTA-202733",
"R-BTA-2454202",
"R-BTA-2730905",
"R-BTA-2871796",
"R-BTA-2871809",
"R-BTA-2871837",
"R-BTA-389948",
"R-BTA-5621480",
"R-BTA-5690714",
"R-BTA-6798695",
"R-BT... | [
"PROSITEDOC:PDOC51055",
"REACTOME:R-BTA-114604",
"REACTOME:R-BTA-198933",
"REACTOME:R-BTA-202424",
"REACTOME:R-BTA-202427",
"REACTOME:R-BTA-202430",
"REACTOME:R-BTA-202433",
"REACTOME:R-BTA-202733",
"REACTOME:R-BTA-2454202",
"REACTOME:R-BTA-2730905",
"REACTOME:R-BTA-2871796",
"REACTOME:R-BTA-2... | 121 | [
"1a81",
"2k4f",
"2oq1",
"3ioz",
"4xz1",
"6jxr",
"7fjd",
"7fje",
"7fjf",
"7q5t",
"7q5u",
"7xq8",
"8e4c",
"8ema",
"8es7",
"8es8",
"8es9",
"8j8i",
"8jc0",
"8jcb",
"8k7t",
"8tw4",
"8tw6",
"8wxe",
"8wy0",
"8wyi",
"8y81",
"8y84",
"8yc0",
"8yrj",
"8ywa",
"8za6"... | 40 | [
"PUB00008053"
] | [
"7594458"
] | [
"Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases."
] | [
1995
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Megaviridae environmental sample",
"bird metagenome"
] | [
7,
3077,
1,
1
] | 4 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
35,
21,
28
] | 4 | true | Repeat | Phosphorylated immunoreceptor signalling ITAM | Phosphorylated immunoreceptor signalling ITAM | Phos_immunorcpt_sig_ITAM | 2 |
IPR003111 | 3,111 | Lon protease, N-terminal domain | Lon_prtase_N | Domain | 54,797 | false | false | This entry represents the N-terminal substrate-binding domain of the Lon protease. This ATP-dependent enzyme, a serine peptidase belonging to the MEROPS peptidase family S16, is conserved in archaeal, bacterial and eukaryotic organisms and catalyses rapid turnover of short-lived regulatory proteins and many damaged or ... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF02190",
"PS51787",
"SM00464"
] | [
"LON_substr_bdg",
"LON_N",
"LON"
] | [
54519,
51807,
51541
] | 3 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.4.21.53",
"R-BTA-9033241",
"R-CEL-9033241",
"R-CEL-9837999",
"R-DDI-9837999",
"R-DME-9837999",
"R-HSA-390471",
"R-HSA-9033241",
"R-HSA-9679191",
"R-HSA-983168",
"R-HSA-9837999",
"R-HSA-9841251",
"R-MMU-9033241",
"R-MMU-983168",
"R-MMU-9837999",
"R-RNO-9033241",
"R-RNO-9837999",
... | [
"EC:3.4.21.53",
"REACTOME:R-BTA-9033241",
"REACTOME:R-CEL-9033241",
"REACTOME:R-CEL-9837999",
"REACTOME:R-DDI-9837999",
"REACTOME:R-DME-9837999",
"REACTOME:R-HSA-390471",
"REACTOME:R-HSA-9033241",
"REACTOME:R-HSA-9679191",
"REACTOME:R-HSA-983168",
"REACTOME:R-HSA-9837999",
"REACTOME:R-HSA-9841... | 20 | [
"1zbo",
"2ane",
"3ljc",
"3m65",
"4ci1",
"4ci2",
"4ci3",
"4tz4",
"5fqd",
"5hxb",
"5v3o",
"6bn7",
"6bn8",
"6bn9",
"6bnb",
"6boy",
"6h0f",
"6h0g",
"6ihg",
"6u5z",
"6uml",
"6vbk",
"6wqh",
"6xk9",
"7cay",
"7cr9",
"7cra",
"7fd4",
"7fd5",
"7fid",
"7fie",
"7fiz"... | 118 | [
"PUB00002870",
"PUB00004808",
"PUB00011879",
"PUB00039341",
"PUB00055624",
"PUB00075692",
"PUB00099721"
] | [
"8276800",
"8248235",
"9620272",
"16199667",
"19191354",
"20834233",
"23999302"
] | [
"PIM1 encodes a mitochondrial ATP-dependent protease that is required for mitochondrial function in the yeast Saccharomyces cerevisiae.",
"A human mitochondrial ATP-dependent protease that is highly homologous to bacterial Lon protease.",
"Maize contains a Lon protease gene that can partially complement a yeast... | [
1994,
1993,
1998,
2005,
2009,
2010,
2013
] | 7 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctCCX1",
"unclassified sequences"
] | [
123,
34147,
19877,
2,
648
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
48,
4,
11,
6,
1,
32,
10,
2,
17,
19,
1,
2,
85
] | 13 | true | Domain | Lon protease, N-terminal domain | Lon protease, N-terminal domain | Lon_prtase_N | 1 |
IPR003112 | 3,112 | Olfactomedin-like domain | Olfac-like_dom | Domain | 22,137 | false | false | The olfactomedin-like or OLF domain is a module of ~260 residues present in metazoan secreted glycoproteins with a characteristic tissue-specific expression. The domain is named after bullfrog olfactomedin, an extracellular matrix protein of olfactory neuroepithelium, whereof it forms the C-terminal part. Other protein... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF02191",
"PS51132",
"SM00284"
] | [
"OLF",
"OLF",
"OLF"
] | [
22128,
22035,
21784
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME"
] | [
"PDOC51132",
"R-HSA-6798695",
"R-MMU-6798695"
] | [
"PROSITEDOC:PDOC51132",
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-6798695"
] | 3 | [
"4d77",
"4d7c",
"4rmk",
"4rml",
"4wxq",
"4wxs",
"4wxu",
"4xat",
"4xav",
"4yeb",
"5afb",
"5amo",
"5cmn",
"5ftt",
"5ftu",
"5yby",
"6jbu",
"6nax",
"6ou0",
"6ou1",
"6ou2",
"6ou3",
"6pkd",
"6pke",
"6pkf",
"6qhj",
"6qm3",
"6ska",
"6vhh",
"7sib",
"7sij",
"7sjt"... | 48 | [
"PUB00014851",
"PUB00014852",
"PUB00018561",
"PUB00018562"
] | [
"12615070",
"12019210",
"11867215",
"15280020"
] | [
"Expression and characterization of the olfactomedin domain of human myocilin.",
"Optimedin: a novel olfactomedin-related protein that interacts with myocilin.",
"Identification and characterization of a novel member of olfactomedin-related protein family, hGC-1, expressed during myeloid lineage development.",
... | [
2003,
2002,
2002,
2004
] | 4 | [] | [] | 0 | 0 | null | [
"Eumetazoa",
"Pseudomonadota",
"bird metagenome"
] | [
22134,
2,
1
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
178,
3,
76,
61,
83
] | 6 | true | Domain | Olfactomedin-like domain | Olfactomedin-like domain | Olfac-like_dom | 7 |
IPR003113 | 3,113 | Phosphatidylinositol 3-kinase, adaptor-binding domain | PI3K_ABD | Domain | 5,971 | false | false | Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that phosphorylate 4,5-bisphonate (PI(4,5) P2 or PIP2) at the 3-position of the inositol ring, and thus generate phosphatidylinositol 3,4,5-trisphosphate (PIP3), which, in turns, initiates a vast array of signaling events. PI3Ks can be grouped into three classes ... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF02192",
"PS51544",
"SM00143"
] | [
"PI3K_p85B",
"PI3K_ABD",
"PI3K_p85B"
] | [
4854,
5941,
4803
] | 3 | [
"EC",
"EC",
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.1.137",
"2.7.1.153",
"2.7.11.1",
"PWY-6352",
"R-BTA-109704",
"R-BTA-112399",
"R-BTA-114604",
"R-BTA-1250342",
"R-BTA-1257604",
"R-BTA-1433557",
"R-BTA-1660499",
"R-BTA-180292",
"R-BTA-186763",
"R-BTA-1963642",
"R-BTA-198203",
"R-BTA-201556",
"R-BTA-202424",
"R-BTA-2029485",
... | [
"EC:2.7.1.137",
"EC:2.7.1.153",
"EC:2.7.11.1",
"METACYC:PWY-6352",
"REACTOME:R-BTA-109704",
"REACTOME:R-BTA-112399",
"REACTOME:R-BTA-114604",
"REACTOME:R-BTA-1250342",
"REACTOME:R-BTA-1257604",
"REACTOME:R-BTA-1433557",
"REACTOME:R-BTA-1660499",
"REACTOME:R-BTA-180292",
"REACTOME:R-BTA-18676... | 208 | [
"2rd0",
"2v1y",
"2y3a",
"3hhm",
"3hiz",
"4a55",
"4jps",
"4l1b",
"4l23",
"4l2y",
"4ovu",
"4ovv",
"4waf",
"4ykn",
"4zop",
"5dxh",
"5dxu",
"5fi4",
"5is5",
"5itd",
"5m6u",
"5ngb",
"5sw8",
"5swg",
"5swo",
"5swp",
"5swr",
"5swt",
"5sx8",
"5sx9",
"5sxa",
"5sxb"... | 119 | [
"PUB00043265",
"PUB00049324",
"PUB00054408"
] | [
"17626883",
"18079394",
"20081827"
] | [
"Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit.",
"The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations.",
"The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors."
] | [
2007,
2007,
2010
] | 3 | [] | [
"IPR045580"
] | 0 | 1 | 0 | [
"Avian sarcoma virus 16",
"Eukaryota",
"Pedobacter caeni"
] | [
1,
5969,
1
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
13,
3,
30,
26,
13
] | 6 | true | Domain | Phosphatidylinositol 3-kinase, adaptor-binding domain | Phosphatidylinositol 3-kinase, adaptor-binding domain | PI3K_ABD | 5 |
IPR003114 | 3,114 | Phox-associated domain | Phox_assoc | Domain | 15,477 | false | false | This domain is found associated with PX domains. The PX (phox) domain [ ] occurs in a variety of eukaryotic proteins associated with intracellular signalling pathways. | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF02194",
"PS51207",
"SM00313"
] | [
"PXA",
"PXA",
"PXA"
] | [
15295,
14870,
13890
] | 3 | [
"PROSITEDOC"
] | [
"PDOC51207"
] | [
"PROSITEDOC:PDOC51207"
] | 1 | [] | 0 | [
"PUB00005042"
] | [
"8931154"
] | [
"Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3-kinases: binding partners of SH3 domains?"
] | [
1996
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halomarina rubra",
"ecological metagenomes",
"uncultured Caudovirales phage"
] | [
22,
15451,
1,
2,
1
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
12,
4,
18,
2,
64,
19,
3,
9,
22,
2,
3,
17
] | 12 | true | Domain | Phox-associated domain | Phox-associated domain | Phox_assoc | 7 |
IPR003115 | 3,115 | ParB-like, N-terminal domain | ParB_N | Domain | 66,504 | false | false | This entry represents the N-terminal domain of ParB proteins, predominantly found in bacteria. Proteins containing this domain include Escherichia coli plasmid protein ParB and mammalian Sulfiredoxin-1 (Srx). This domain is characterised by a highly conserved arginine motig, RRXR, known as the arginine patch, which is ... | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF02195",
"SM00470"
] | [
"ParB_N",
"ParB"
] | [
60363,
64542
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-9818027",
"R-HSA-9818027",
"R-MMU-9818027",
"R-SCE-9818027",
"R-SPO-9818027"
] | [
"REACTOME:R-DME-9818027",
"REACTOME:R-HSA-9818027",
"REACTOME:R-MMU-9818027",
"REACTOME:R-SCE-9818027",
"REACTOME:R-SPO-9818027"
] | 5 | [
"1vk1",
"1vz0",
"1xw3",
"1xw4",
"1yzs",
"2b6f",
"2rii",
"3cyi",
"3hy2",
"4umk",
"5k5a",
"5k5d",
"5ujd",
"5uje",
"5x0b",
"5x0e",
"5x0f",
"5x0g",
"5x0j",
"5x0k",
"6ky4",
"6nr6",
"6ryk",
"6sdk",
"6t1f",
"7bm8",
"7bnk",
"7bnr",
"7lj1",
"7nfu",
"7ng0",
"7o0n"... | 35 | [
"PUB00032130",
"PUB00068087",
"PUB00068088",
"PUB00085711",
"PUB00137953",
"PUB00153758",
"PUB00153775",
"PUB00153776",
"PUB00160262"
] | [
"15228524",
"15448164",
"12603730",
"25358815",
"25964325",
"31835030",
"11532141",
"15917647",
"34562373"
] | [
"Structural analysis of the chromosome segregation protein Spo0J from Thermus thermophilus.",
"Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine.",
"Productive interaction between the chromoso... | [
2004,
2004,
2003,
2014,
2015,
2019,
2001,
2005,
2021
] | 9 | [] | [
"IPR004437",
"IPR037953"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"plasmids",
"unclassified sequences"
] | [
994,
61323,
2181,
629,
11,
1366
] | 6 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
... | [
5,
5,
3,
4,
1,
2,
4,
4,
1,
1,
5
] | 11 | true | Domain | ParB-like, N-terminal domain | ParB-like, N-terminal domain | ParB_N | 3 |
IPR003116 | 3,116 | Raf-like Ras-binding | RBD_dom | Domain | 12,417 | false | false | Ras and heterotrimeric G proteins' alpha subunits are signal-transducing GTPases that cycle between inactive GDP-bound and active GTP-bound forms. The activities of these GTPases are regulated in part by GTPase-activating protein (GAPs) that stimulate hydrolysis of GTP, and guanine nucleotide exchange factors (GEFs) th... | [
"GO:0007165"
] | [
"signal transduction"
] | [
"biological_process"
] | 1 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF02196",
"PS50898",
"SM00455"
] | [
"RBD",
"RBD",
"RBD"
] | [
11270,
12017,
11212
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC50898",
"R-CEL-170968",
"R-CEL-2672351",
"R-CEL-392517",
"R-CEL-430116",
"R-CEL-5621575",
"R-CEL-5673000",
"R-CEL-5674135",
"R-CEL-5674499",
"R-CEL-5675221",
"R-DDI-1257604",
"R-DDI-389357",
"R-DDI-5218920",
"R-DDI-6804757",
"R-DDI-9856530",
"R-DME-1295596",
"R-DME-170968",
"R... | [
"PROSITEDOC:PDOC50898",
"REACTOME:R-CEL-170968",
"REACTOME:R-CEL-2672351",
"REACTOME:R-CEL-392517",
"REACTOME:R-CEL-430116",
"REACTOME:R-CEL-5621575",
"REACTOME:R-CEL-5673000",
"REACTOME:R-CEL-5674135",
"REACTOME:R-CEL-5674499",
"REACTOME:R-CEL-5675221",
"REACTOME:R-DDI-1257604",
"REACTOME:R-D... | 115 | [
"1c1y",
"1gua",
"1rfa",
"1rrb",
"1wfy",
"1wxm",
"2l05",
"2mse",
"3kuc",
"3kud",
"3ny5",
"4g0n",
"4g3x",
"5j17",
"5j18",
"5j2r",
"5yxi",
"6ntc",
"6ntd",
"6nyb",
"6pts",
"6ptw",
"6q0j",
"6q0k",
"6q0t",
"6uan",
"6vjj",
"6xgu",
"6xgv",
"6xha",
"6xhb",
"6xi7"... | 64 | [
"PUB00011828",
"PUB00018368"
] | [
"10606204",
"7791872"
] | [
"Raf-like Ras/Rap-binding domains in RGS12- and still-life-like signalling proteins.",
"The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue."
] | [
1999,
1995
] | 2 | [] | [
"IPR046992",
"IPR046993"
] | 0 | 2 | 0 | [
"Eukaryota"
] | [
12417
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
95,
19,
53,
27,
40
] | 6 | true | Domain | Raf-like Ras-binding | Raf-like Ras-binding | RBD_dom | 2 |
IPR003117 | 3,117 | cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain | cAMP_dep_PK_reg_su_I/II_a/b | Domain | 8,654 | false | false | Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substra... | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF02197",
"SM00394"
] | [
"RIIa",
"RIIa"
] | [
8551,
7985
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-163615",
"R-BTA-164378",
"R-BTA-180024",
"R-BTA-432040",
"R-BTA-442720",
"R-BTA-5610787",
"R-BTA-9634597",
"R-BTA-983231",
"R-BTA-9856530",
"R-CEL-163615",
"R-CEL-164378",
"R-CEL-180024",
"R-CEL-432040",
"R-CEL-442720",
"R-CEL-5610787",
"R-CEL-9634597",
"R-CEL-983231",
"R-CE... | [
"REACTOME:R-BTA-163615",
"REACTOME:R-BTA-164378",
"REACTOME:R-BTA-180024",
"REACTOME:R-BTA-432040",
"REACTOME:R-BTA-442720",
"REACTOME:R-BTA-5610787",
"REACTOME:R-BTA-9634597",
"REACTOME:R-BTA-983231",
"REACTOME:R-BTA-9856530",
"REACTOME:R-CEL-163615",
"REACTOME:R-CEL-164378",
"REACTOME:R-CEL-... | 110 | [
"1l6e",
"1r2a",
"2drn",
"2ezw",
"2h9r",
"2hwn",
"2izx",
"2izy",
"2kyg",
"3im3",
"3im4",
"3j4q",
"3j4r",
"3tmh",
"3tnp",
"3tnq",
"4din",
"4f9k",
"4mx3",
"4wbb",
"4x6q",
"4zp3",
"5h77",
"5h78",
"5hvz",
"5xby",
"6byr",
"6bys",
"6no7",
"6wjf",
"6wjg",
"6xqk"... | 44 | [
"PUB00005115",
"PUB00007194",
"PUB00015362",
"PUB00020114",
"PUB00034898",
"PUB00034899",
"PUB00040294"
] | [
"3291115",
"11734894",
"12368087",
"12471243",
"15078142",
"15320712",
"11285229"
] | [
"The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.",
"Classification and phylogenetic analysis of the cAMP-dependent protein kinase regulatory subunit family.",
"Evolution of protein kinase signaling from yeast to man.",
"The protein kinase complement of the human g... | [
1988,
2002,
2002,
2002,
2004,
2004,
2001
] | 7 | [] | [
"IPR042818",
"IPR047579"
] | 0 | 2 | 0 | [
"Eukaryota"
] | [
8654
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
4,
16,
3,
51,
26,
24,
1,
1
] | 8 | true | Domain | cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain | cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain | cAMP_dep_PK_reg_su_I/II_a/b | 4 |
IPR003118 | 3,118 | Pointed domain | Pointed_dom | Domain | 16,476 | false | false | The highly conserved PNT (or Pointed) domain is found within a subset of the Ets transcription factors, including mammalian Ets-1, Ets-2, Erg, Fli-1, GABPalpha, and Tel, as well as Drosophila Pnt-P2 and Yan. The PNT domain is structurally related to the larger group of SAM domains through a common tertiary arrangement ... | [
"GO:0043565"
] | [
"sequence-specific DNA binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF02198",
"PS51433",
"SM00251"
] | [
"SAM_PNT",
"PNT",
"SAM_PNT"
] | [
16167,
15838,
15851
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-2559585",
"R-DME-2151201",
"R-DME-2559585",
"R-DME-8939245",
"R-HSA-1912408",
"R-HSA-2151201",
"R-HSA-2559585",
"R-HSA-9616222",
"R-HSA-9673768",
"R-HSA-9703465",
"R-MMU-1912408",
"R-MMU-2151201",
"R-MMU-2559585",
"R-RNO-1912408",
"R-RNO-2559585"
] | [
"REACTOME:R-BTA-2559585",
"REACTOME:R-DME-2151201",
"REACTOME:R-DME-2559585",
"REACTOME:R-DME-8939245",
"REACTOME:R-HSA-1912408",
"REACTOME:R-HSA-2151201",
"REACTOME:R-HSA-2559585",
"REACTOME:R-HSA-9616222",
"REACTOME:R-HSA-9673768",
"REACTOME:R-HSA-9703465",
"REACTOME:R-MMU-1912408",
"REACTOM... | 15 | [
"1ji7",
"1lky",
"1sv0",
"1sv4",
"1sxd",
"1sxe",
"1x66",
"2dkx",
"2e8p",
"2jv3",
"2kmd",
"2qar",
"2qb0",
"2qb1",
"2ytu",
"4mhv",
"5l0p",
"7ju2",
"7n1o",
"7n2b",
"7t8j",
"7tdy",
"7tw7",
"7tw8",
"7tw9",
"7u4w",
"7u4z",
"8bwu",
"8e1f",
"8frj",
"8frk",
"8ft6"... | 51 | [
"PUB00031232",
"PUB00052613"
] | [
"15351649",
"10828014"
] | [
"Diversity in structure and function of the Ets family PNT domains.",
"Identification and characterization of a new human ETS-family transcription factor, TEL2, that is expressed in hematopoietic tissues and can associate with TEL1/ETV6."
] | [
2004,
2000
] | 2 | [] | [
"IPR033071",
"IPR035573",
"IPR041886",
"IPR042693"
] | 0 | 4 | 0 | [
"Avian leukemia virus E26",
"Eukaryota"
] | [
1,
16475
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
75,
15,
62,
53,
49
] | 6 | true | Domain | Pointed domain | Pointed domain | Pointed_dom | 5 |
IPR003119 | 3,119 | Saposin A-type domain | SAP_A | Domain | 4,684 | false | false | The saposin A-type domain is a ~40 amino acid domain present in the saposin precursor, prosaposin, in the propeptides that are cleaved off in the activation reaction. The domain is named after the small lysosomal proteins, saposins, which serve as sphingolipid hydrolase activator proteins in vertebrates. The mammalian ... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF02199",
"PS51110",
"SM00162"
] | [
"SapA",
"SAP_A",
"SAPA"
] | [
4380,
4520,
3559
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC51110",
"R-BTA-5683826",
"R-DRE-2132295",
"R-HSA-114608",
"R-HSA-375276",
"R-HSA-418594",
"R-HSA-5683826",
"R-HSA-5688031",
"R-HSA-5688849",
"R-HSA-5688890",
"R-HSA-6798695",
"R-HSA-9840310",
"R-MMU-114608",
"R-MMU-375276",
"R-MMU-418594",
"R-MMU-5683826",
"R-MMU-6798695",
"R-... | [
"PROSITEDOC:PDOC51110",
"REACTOME:R-BTA-5683826",
"REACTOME:R-DRE-2132295",
"REACTOME:R-HSA-114608",
"REACTOME:R-HSA-375276",
"REACTOME:R-HSA-418594",
"REACTOME:R-HSA-5683826",
"REACTOME:R-HSA-5688031",
"REACTOME:R-HSA-5688849",
"REACTOME:R-HSA-5688890",
"REACTOME:R-HSA-6798695",
"REACTOME:R-H... | 24 | [] | 0 | [
"PUB00016998",
"PUB00018544"
] | [
"8702672",
"11856752"
] | [
"Structural requirements for targeting of surfactant protein B (SP-B) to secretory granules in vitro and in vivo.",
"The lysosomal transport of prosaposin requires the conditional interaction of its highly conserved d domain with sphingomyelin."
] | [
1996,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
7,
4677
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
1,
12,
28,
18
] | 5 | true | Domain | Saposin A-type domain | Saposin A-type domain | SAP_A | 3 |
IPR003120 | 3,120 | Transcription factor Ste12, N-terminal domain | Ste12_N | Domain | 1,980 | false | false | This entry include a group of fungal transcription factors, including Ste12, Cph1, SteA and MST12. In S. cerevisiae, Ste12 mediates transcriptional induction of cell type-specific genes in response to pheromones [ , ]. Aspergillus nidulans SteA, an homodomain-containing protein, is required for sexual reproduction [ ].... | [
"GO:0003700",
"GO:0006355",
"GO:0005634"
] | [
"DNA-binding transcription factor activity",
"regulation of DNA-templated transcription",
"nucleus"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"SMART"
] | [
"PF02200",
"SM00424"
] | [
"STE",
"STE"
] | [
1980,
1926
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00015135",
"PUB00078841",
"PUB00078843",
"PUB00097854",
"PUB00097867"
] | [
"8339934",
"2558054",
"10792717",
"21283781",
"11952120"
] | [
"Coupling of cell identity to signal response in yeast: interaction between the alpha 1 and STE12 proteins.",
"STE12, a protein involved in cell-type-specific transcription and signal transduction in yeast, is part of protein-DNA complexes.",
"Aspergillus SteA (sterile12-like) is a homeodomain-C2/H2-Zn+2 finger... | [
1993,
1989,
2000,
2011,
2002
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1980
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Domain | Transcription factor Ste12, N-terminal domain | Transcription factor Ste12, N-terminal domain | Ste12_N | 1 |
IPR003121 | 3,121 | SWIB/MDM2 domain | SWIB_MDM2_domain | Domain | 26,338 | false | false | The SWI/SNF family of complexes, which are conserved from yeast to humans, are ATP-dependent chromatin-remodelling proteins that facilitate transcription activation [ , , ]. The mammalian complexes are made up of 9-12 proteins called BAFs (BRG1-associated factors). The BAF60 family have at least three members: BAF60a, ... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE"
] | [
"PF02201",
"PS51925"
] | [
"SWIB",
"SWIB_MDM2"
] | [
23467,
25457
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-3214858",
"R-BTA-8939243",
"R-BTA-9933939",
"R-BTA-9933946",
"R-BTA-9933947",
"R-BTA-9934037",
"R-CEL-8939243",
"R-CEL-9933937",
"R-CEL-9933939",
"R-CEL-9933946",
"R-CEL-9934037",
"R-CFA-2559580",
"R-CFA-2559585",
"R-CFA-399719",
"R-CFA-5689880",
"R-CFA-6804756",
"R-CFA-680475... | [
"REACTOME:R-BTA-3214858",
"REACTOME:R-BTA-8939243",
"REACTOME:R-BTA-9933939",
"REACTOME:R-BTA-9933946",
"REACTOME:R-BTA-9933947",
"REACTOME:R-BTA-9934037",
"REACTOME:R-CEL-8939243",
"REACTOME:R-CEL-9933937",
"REACTOME:R-CEL-9933939",
"REACTOME:R-CEL-9933946",
"REACTOME:R-CEL-9934037",
"REACTOM... | 115 | [
"1rv1",
"1t4e",
"1t4f",
"1ttv",
"1uhr",
"1v31",
"1v32",
"1ycq",
"1ycr",
"1z1m",
"2axi",
"2gv2",
"2lzg",
"2m86",
"2mps",
"2mwy",
"2n06",
"2n0u",
"2n0w",
"2n14",
"2ruh",
"2vyr",
"2z5s",
"2z5t",
"3dab",
"3dac",
"3eqs",
"3eqy",
"3fdo",
"3fe7",
"3fea",
"3g03"... | 196 | [
"PUB00013998",
"PUB00014853",
"PUB00014864",
"PUB00088122",
"PUB00097572",
"PUB00097573",
"PUB00097574"
] | [
"8875929",
"11147808",
"12016060",
"22952240",
"28736176",
"26791088",
"28420746"
] | [
"Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.",
"Characterization of SWI/SNF protein expression in human breast cancer cell lines and other malignancies.",
"The SWIB and the MDM2 domains are homologous and share a common fold.",
"SWI/SNF chromatin-remodeling fact... | [
1996,
2001,
2002,
2012,
2017,
2016,
2017
] | 7 | [] | [
"IPR019835"
] | 0 | 1 | 0 | [
"Bacteria",
"Candidatus Iainarchaeum sp.",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
1903,
1,
24041,
75,
318
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
95,
3,
29,
2,
59,
24,
2,
38,
29,
3,
2,
174
] | 12 | true | Domain | SWIB/MDM2 domain | SWIB/MDM2 domain | SWIB_MDM2_domain | 9 |
IPR003122 | 3,122 | Chemotaxis methyl-accepting receptor Tar-related, ligand-binding | Tar_rcpt_lig-bd | Domain | 14,854 | false | false | Methyl-accepting chemotaxis proteins (MCPs) are a family of bacterial receptors that mediate chemotaxis to diverse signals, responding to changes in the concentration of attractants and repellents in the environment by altering swimming behaviour [ ]. Environmental diversity gives rise to diversity in bacterial signall... | [
"GO:0006935",
"GO:0007165"
] | [
"chemotaxis",
"signal transduction"
] | [
"biological_process",
"biological_process"
] | 2 | [
"PFAM",
"SMART"
] | [
"PF02203",
"SM00319"
] | [
"TarH",
"TarH"
] | [
14368,
6452
] | 2 | [] | [] | [] | 0 | [
"1jmw",
"1lih",
"1vls",
"1vlt",
"1was",
"1wat",
"2asr",
"2d4u",
"2lig",
"3atp",
"4z9h",
"4z9i",
"4z9j",
"6s18",
"6s1a",
"6s1k",
"6s33",
"6s37",
"6s38",
"6s3b",
"7w0w",
"8c5v",
"8fyv",
"8vl8"
] | 24 | [
"PUB00023112",
"PUB00042592",
"PUB00042593",
"PUB00085578",
"PUB00085580"
] | [
"1660187",
"16359703",
"17299051",
"27292793",
"21689529"
] | [
"Three-dimensional structures of the ligand-binding domain of the bacterial aspartate receptor with and without a ligand.",
"Changing the specificity of a bacterial chemoreceptor.",
"Evolutionary genomics reveals conserved structural determinants of signaling and adaptation in microbial chemoreceptors.",
"Str... | [
1991,
2006,
2007,
2016,
2011
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
14747,
34,
73
] | 3 | [
"Escherichia coli (strain K12)"
] | [
4
] | 1 | true | Domain | Chemotaxis methyl-accepting receptor Tar-related, ligand-binding | Chemotaxis methyl-accepting receptor Tar-related, ligand-binding | Tar_rcpt_lig-bd | 2 |
IPR003124 | 3,124 | WH2 domain | WH2_dom | Domain | 32,696 | false | false | The WH2 (WASP-Homology 2, or Wiskott-Aldrich homology 2) domain is an ~18 amino acids actin-binding motif. This domain was first recognised as an essential element for the regulation of the cytoskeleton by the mammalian Actin nucleation-promoting factor WAS (also known asWiskott-Aldrich syndrome protein, WASP). WH2 pro... | [
"GO:0003779"
] | [
"actin binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF02205",
"PS51082",
"SM00246"
] | [
"WH2",
"WH2",
"WH2"
] | [
21037,
30907,
14073
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC51082",
"R-BTA-2029482",
"R-BTA-203641",
"R-BTA-373753",
"R-BTA-3928662",
"R-BTA-418885",
"R-BTA-4420097",
"R-BTA-5663213",
"R-BTA-8856828",
"R-BTA-9013149",
"R-BTA-9013404",
"R-BTA-9013406",
"R-BTA-9013423",
"R-BTA-9013424",
"R-DDI-2029482",
"R-DDI-446353",
"R-DDI-5658442",
"... | [
"PROSITEDOC:PDOC51082",
"REACTOME:R-BTA-2029482",
"REACTOME:R-BTA-203641",
"REACTOME:R-BTA-373753",
"REACTOME:R-BTA-3928662",
"REACTOME:R-BTA-418885",
"REACTOME:R-BTA-4420097",
"REACTOME:R-BTA-5663213",
"REACTOME:R-BTA-8856828",
"REACTOME:R-BTA-9013149",
"REACTOME:R-BTA-9013404",
"REACTOME:R-B... | 63 | [
"2a3z",
"2a40",
"2a41",
"2d1k",
"2vcp",
"3m1f",
"3m3n",
"3mn5",
"3mn7",
"3p8c",
"3tu5",
"3ue5",
"4efh",
"4jhd",
"4n78",
"4rwt",
"5wfn",
"5ypu",
"6jbk",
"6jcu",
"6jh8",
"6jh9",
"6uhc",
"7usc",
"7usd",
"7use",
"8rv2",
"9azp",
"9rwf"
] | 29 | [
"PUB00016992",
"PUB00016993",
"PUB00101129"
] | [
"11434350",
"11911886",
"35667337"
] | [
"WASP homology sequences in baculoviruses.",
"WH2 domain: a small, versatile adapter for actin monomers.",
"WASP family proteins: Molecular mechanisms and implications in human disease."
] | [
2001,
2002,
2022
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
392,
32112,
183,
9
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
10,
112,
36,
89,
60,
2,
10,
82,
2,
3,
19
] | 12 | true | Domain | WH2 domain | WH2 domain | WH2_dom | 7 |
IPR003126 | 3,126 | Zinc finger, UBR-type | Znf_UBR | Domain | 21,451 | false | false | It has been observed that the identity of N-terminal residues of a protein is related to the half life of the protein. This observation yields a rule, called the N-end rule [ ]. Similar but distinct versions of the N-end rule operate in all organisms examined, from mammals to fungi and bacteria. In eukaryotes, the N-en... | [
"GO:0008270"
] | [
"zinc ion binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF02207",
"PS51157",
"SM00396"
] | [
"zf-UBR",
"ZF_UBR",
"ZnF_UBR1"
] | [
17587,
20677,
21185
] | 3 | [
"EC",
"GP",
"METACYC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.3.2.27",
"GenProp1754",
"PWY-7511",
"PDOC51157",
"R-CEL-8951664",
"R-CEL-983168",
"R-DDI-6798695",
"R-DDI-983168",
"R-DME-6798695",
"R-DME-983168",
"R-HSA-6798695",
"R-HSA-8951664",
"R-HSA-983168",
"R-MMU-6798695",
"R-MMU-8951664",
"R-MMU-983168",
"R-RNO-6798695",
"R-RNO-8951664... | [
"EC:2.3.2.27",
"GP:GenProp1754",
"METACYC:PWY-7511",
"PROSITEDOC:PDOC51157",
"REACTOME:R-CEL-8951664",
"REACTOME:R-CEL-983168",
"REACTOME:R-DDI-6798695",
"REACTOME:R-DDI-983168",
"REACTOME:R-DME-6798695",
"REACTOME:R-DME-983168",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-8951664",
"REACTOME:... | 21 | [
"3nih",
"3nii",
"3nij",
"3nik",
"3nil",
"3nim",
"3nin",
"3nis",
"3nit",
"3ny1",
"3ny2",
"3ny3",
"5tda",
"5tdb",
"5tdc",
"5tdd",
"5um3",
"5vmd",
"6kgi",
"6lhn",
"7mex",
"7mey",
"7wuk",
"7wul",
"7wum",
"7wun",
"7xwd",
"7xwe",
"7xwf",
"7xwg",
"7y6w",
"7y6x"... | 64 | [
"PUB00033696",
"PUB00033766",
"PUB00033767",
"PUB00033768"
] | [
"16055722",
"8901547",
"10545113",
"10581257"
] | [
"A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.",
"The N-end rule: functions, mysteries, uses.",
"Degradation signals in the lysine-asparagine sequence space.",
"The E2-E3 interaction in the N-end rule pathway: the RING-H2 finger of E3 is required for the sy... | [
2005,
1996,
1999,
1999
] | 4 | [] | [
"IPR047503",
"IPR047504",
"IPR047506",
"IPR047507",
"IPR047508",
"IPR047509"
] | 0 | 6 | 0 | [
"Eukaryota",
"Viruses"
] | [
21440,
11
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
19,
10,
110,
13,
21,
24,
2,
6,
26,
2,
3,
19
] | 12 | true | Domain | Zinc finger, UBR-type | Zinc finger, UBR-type | Znf_UBR | 3 |
IPR003127 | 3,127 | SoHo domain | SoHo_dom | Domain | 9,235 | false | false | Sorbin is an active peptide present in the digestive tract, where it has pro-absorptive and anti-secretory effects in different parts of the intestine, including the ability to decrease VIP (vasoactive intestinal peptide) and cholera toxin-induced secretion. It is expressed in some intestinal and pancreatic endocrine t... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF02208",
"PS50831",
"SM00459"
] | [
"Sorb",
"SOHO",
"Sorb"
] | [
8015,
9196,
8487
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC50831",
"R-CEL-264870",
"R-CEL-445355",
"R-CEL-6794361",
"R-CEL-6798695",
"R-HSA-445355",
"R-MMU-264870",
"R-MMU-445355",
"R-MMU-6794361",
"R-MMU-6798695",
"R-RNO-264870",
"R-RNO-6794361",
"R-RNO-6798695"
] | [
"PROSITEDOC:PDOC50831",
"REACTOME:R-CEL-264870",
"REACTOME:R-CEL-445355",
"REACTOME:R-CEL-6794361",
"REACTOME:R-CEL-6798695",
"REACTOME:R-HSA-445355",
"REACTOME:R-MMU-264870",
"REACTOME:R-MMU-445355",
"REACTOME:R-MMU-6794361",
"REACTOME:R-MMU-6798695",
"REACTOME:R-RNO-264870",
"REACTOME:R-RNO-... | 13 | [] | 0 | [
"PUB00014858",
"PUB00014859",
"PUB00014860",
"PUB00068763"
] | [
"10704721",
"11937713",
"11481476",
"15949647"
] | [
"Inhibitory effect of sorbin on pepsin secretion in conscious cats and rabbits.",
"Vinexin, CAP/ponsin, ArgBP2: a novel adaptor protein family regulating cytoskeletal organization and signal transduction.",
"The sorbin homology domain: a motif for the targeting of proteins to lipid rafts.",
"Human sorbin is g... | [
2000,
2002,
2001,
2005
] | 4 | [] | [] | 0 | 0 | null | [
"Edaphosphingomonas laterariae",
"Eukaryota"
] | [
1,
9234
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
175,
9,
32,
28,
31
] | 6 | true | Domain | SoHo domain | SoHo domain | SoHo_dom | 4 |
IPR003128 | 3,128 | Villin headpiece | Villin_headpiece | Domain | 21,487 | false | false | Villin is an F-actin bundling protein involved in the maintenance of the microvilli of the absorptive epithelia. The villin-type "headpiece" domain is a modular motif found at the extreme C terminus of larger "core" domains in over 25 cytoskeletal proteins in plants and animals, often in assocation with the Gelsolin re... | [
"GO:0003779",
"GO:0007010"
] | [
"actin binding",
"cytoskeleton organization"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF02209",
"PS51089",
"SM00153"
] | [
"VHP",
"HP",
"VHP"
] | [
21087,
21418,
21066
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC51089",
"R-BTA-5223345",
"R-DDI-114608",
"R-DDI-6798695",
"R-DME-264870",
"R-DME-6798695",
"R-HSA-418885",
"R-HSA-5223345",
"R-MMU-5223345"
] | [
"PROSITEDOC:PDOC51089",
"REACTOME:R-BTA-5223345",
"REACTOME:R-DDI-114608",
"REACTOME:R-DDI-6798695",
"REACTOME:R-DME-264870",
"REACTOME:R-DME-6798695",
"REACTOME:R-HSA-418885",
"REACTOME:R-HSA-5223345",
"REACTOME:R-MMU-5223345"
] | 9 | [
"1qqv",
"1qzp",
"1ujs",
"1unc",
"1und",
"1vii",
"1wy3",
"1wy4",
"1yrf",
"1yri",
"1yu5",
"1yu7",
"1yu8",
"1zv6",
"2f4k",
"2jm0",
"2k6m",
"2k6n",
"2l3x",
"2ppz",
"2rjv",
"2rjw",
"2rjx",
"2rjy",
"3iur",
"3j92",
"3mya",
"3myc",
"3mye",
"3nkj",
"3tjw",
"3trv"... | 57 | [
"PUB00007540",
"PUB00007541"
] | [
"11977079",
"12095260"
] | [
"Villin-type headpiece domains show a wide range of F-actin-binding affinities.",
"Temperature-dependent dynamics of the villin headpiece helical subdomain, an unusually small thermostable protein."
] | [
2002,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Eukaryota",
"metagenomes"
] | [
35,
21450,
2
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
28,
4,
172,
18,
31,
41,
10,
44,
72
] | 9 | true | Domain | Villin headpiece | Villin headpiece | Villin_headpiece | 4 |
IPR003130 | 3,130 | Dynamin GTPase effector | GED | Domain | 30,588 | false | false | This entry represents the dynamin GTPase effector domain (GED) found in proteins related to dynamin. Its C-terminal region constitutes one of the helices of the bundle signalling element (BSE) or neck together with the N- and C-terminal regions from the GTPase domain, being in close proximity and functionally linked to... | [
"GO:0003924",
"GO:0005525"
] | [
"GTPase activity",
"GTP binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM",
"SMART"
] | [
"PF02212",
"SM00302"
] | [
"GED",
"GED"
] | [
30565,
26809
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1169408",
"R-BTA-166016",
"R-BTA-190873",
"R-BTA-196025",
"R-BTA-2132295",
"R-BTA-437239",
"R-BTA-75153",
"R-BTA-8856828",
"R-CEL-190873",
"R-CEL-196025",
"R-CEL-3928665",
"R-CEL-432720",
"R-CEL-432722",
"R-CEL-437239",
"R-CEL-75153",
"R-CEL-8856828",
"R-CFA-1169408",
"R-DDI... | [
"REACTOME:R-BTA-1169408",
"REACTOME:R-BTA-166016",
"REACTOME:R-BTA-190873",
"REACTOME:R-BTA-196025",
"REACTOME:R-BTA-2132295",
"REACTOME:R-BTA-437239",
"REACTOME:R-BTA-75153",
"REACTOME:R-BTA-8856828",
"REACTOME:R-CEL-190873",
"REACTOME:R-CEL-196025",
"REACTOME:R-CEL-3928665",
"REACTOME:R-CEL-... | 74 | [
"3ljb",
"3snh",
"3szr",
"3zvr",
"3zys",
"4bej",
"4uud",
"4uuk",
"4whj",
"4x0r",
"5a3f",
"5gtm",
"5uot",
"5wp9",
"6dlu",
"6dlv",
"6fgz",
"7ax3",
"8sxz",
"8sz4",
"8sz7",
"8sz8",
"8t0k",
"8t0r",
"8t1h",
"8tym",
"8tyn",
"8v8t"
] | 28 | [
"PUB00015628",
"PUB00072539"
] | [
"10206643",
"22233676"
] | [
"Impairment of dynamin's GAP domain stimulates receptor-mediated endocytosis.",
"Dynamin, a membrane-remodelling GTPase."
] | [
1999,
2012
] | 2 | [
"IPR020850"
] | [] | 1 | 0 | 1 | [
"Eukaryota",
"Mimiviridae",
"metagenomes"
] | [
30571,
11,
6
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
53,
3,
86,
13,
35,
34,
2,
31,
45,
2,
2,
88
] | 12 | true | Domain | Dynamin GTPase effector | Dynamin GTPase effector | GED | 3 |
IPR003131 | 3,131 | Potassium channel tetramerisation-type BTB domain | T1-type_BTB | Domain | 69,154 | false | false | This domain can be found at the N-terminal of voltage-gated potassium channel protein. It represents a cytoplasmic tetramerisation domain (T1) involved in assembly of alpha-subunits into functional tetrameric channels [ ]. This domain can also be found in proteins that are not potassium channels, like KCTD1 (potassium ... | [
"GO:0051260"
] | [
"protein homooligomerization"
] | [
"biological_process"
] | 1 | [
"PFAM"
] | [
"PF02214"
] | [
"BTB_2"
] | [
69154
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1296072",
"R-BTA-5576894",
"R-BTA-8951664",
"R-BTA-983168",
"R-CEL-381676",
"R-CEL-5576890",
"R-CEL-8951664",
"R-CEL-983168",
"R-DME-1296072",
"R-DME-381676",
"R-DME-5576890",
"R-DME-5576894",
"R-DME-8866904",
"R-DRE-8951664",
"R-DRE-9696264",
"R-DRE-9696270",
"R-DRE-983168",
... | [
"REACTOME:R-BTA-1296072",
"REACTOME:R-BTA-5576894",
"REACTOME:R-BTA-8951664",
"REACTOME:R-BTA-983168",
"REACTOME:R-CEL-381676",
"REACTOME:R-CEL-5576890",
"REACTOME:R-CEL-8951664",
"REACTOME:R-CEL-983168",
"REACTOME:R-DME-1296072",
"REACTOME:R-DME-381676",
"REACTOME:R-DME-5576890",
"REACTOME:R-... | 54 | [
"1a68",
"1dsx",
"1eod",
"1eoe",
"1eof",
"1exb",
"1nn7",
"1qdv",
"1qdw",
"1s1g",
"1t1d",
"2a79",
"2i2r",
"2nz0",
"2r9r",
"3drx",
"3dry",
"3drz",
"3kvt",
"3lnm",
"3lut",
"4bgc",
"4crh",
"4jta",
"4jtc",
"4jtd",
"4uij",
"4yy8",
"4zgc",
"5a15",
"5a6r",
"5bxb"... | 124 | [
"PUB00006428",
"PUB00058068",
"PUB00058069"
] | [
"9886290",
"18358072",
"19115315"
] | [
"Zn2+-binding and molecular determinants of tetramerization in voltage-gated K+ channels.",
"Characterization and expression of a human KCTD1 gene containing the BTB domain, which mediates transcriptional repression and homomeric interactions.",
"The interaction of KCTD1 with transcription factor AP-2alpha inhi... | [
1999,
2008,
2009
] | 3 | [
"IPR000210"
] | [
"IPR045904",
"IPR046988",
"IPR047825",
"IPR048010",
"IPR048219",
"IPR048599",
"IPR057891"
] | 1 | 7 | 0 | [
"Bacteria",
"Eukaryota",
"Viruses",
"viral metagenome"
] | [
3,
68913,
209,
29
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Zea mays"
] | [
15,
80,
153,
38,
129,
104,
12,
139,
1,
12
] | 10 | true | Domain | Potassium channel tetramerisation-type BTB domain | Potassium channel tetramerisation-type BTB domain | T1-type_BTB | 7 |
IPR003132 | 3,132 | Protein A, Ig-binding domain | Protein_A_Ig-bd | Domain | 316 | false | false | This entry represents the immunoglobulin-binding domain found in the Staphylococcus aureus virulence factor protein A (SpA). Protein A contains five highly homologous Ig-binding domains in tandem (designated domains E, D, A, B and C), which share a common structure consisting of three helices in a closed left-handed tw... | [
"GO:0019865"
] | [
"immunoglobulin binding"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF02216"
] | [
"B"
] | [
316
] | 1 | [] | [] | [] | 0 | [
"1bdc",
"1bdd",
"1dee",
"1edi",
"1edj",
"1edk",
"1edl",
"1fc2",
"1h0t",
"1l6x",
"1lp1",
"1oqo",
"1oqx",
"1q2n",
"1ss1",
"1zda",
"1zdb",
"1zdc",
"1zdd",
"1zxg",
"1zxh",
"2b87",
"2b88",
"2b89",
"2jwd",
"2kzi",
"2kzj",
"2lr2",
"2m5a",
"2otk",
"2spz",
"2y7j"... | 173 | [
"PUB00013211"
] | [
"10805799"
] | [
"Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: structural basis for recognition of B-cell receptors and superantigen activity."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
316
] | 1 | [] | [] | 0 | true | Domain | Protein A, Ig-binding domain | Protein A, Ig-binding domain | Protein_A_Ig-bd | 5 |
IPR003134 | 3,134 | Hs1/Cortactin | Hs1_Cortactin | Repeat | 3,485 | false | false | The cortactin or HS1 repeat is a tandem repeat of 37-amino acid actin-binding domains. The repeat is named after human cortactin and HS1, proteins involved in cytoskeletal rearrangements implicated in cell migration and apoptosis, respectively. Cortactin contains 6.5 tandem copies of the repeat and is conserved among m... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE"
] | [
"PF02218",
"PS51090"
] | [
"HS1_rep",
"CORTACTIN"
] | [
3424,
3481
] | 2 | [
"PROSITEDOC",
"REACTOME",
"REACTOME"
] | [
"PDOC51090",
"R-HSA-5627123",
"R-HSA-8856828"
] | [
"PROSITEDOC:PDOC51090",
"REACTOME:R-HSA-5627123",
"REACTOME:R-HSA-8856828"
] | 3 | [
"8p94"
] | 1 | [
"PUB00016990",
"PUB00016991"
] | [
"12534372",
"15186216"
] | [
"Haematopoietic lineage cell-specific protein 1 (HS1) promotes actin-related protein (Arp) 2/3 complex-mediated actin polymerization.",
"Cortactin signalling and dynamic actin networks."
] | [
2003,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine sediment metagenome"
] | [
13,
3471,
1
] | 3 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
2,
9,
7,
13
] | 5 | true | Repeat | Hs1/Cortactin | Hs1/Cortactin | Hs1_Cortactin | 7 |
IPR003136 | 3,136 | Cytidylate kinase | Cytidylate_kin | Family | 24,319 | false | false | Cytidylate kinase ( ) catalyses the phosphorylation of cytidine 5-monophosphate (dCMP) to cytidine 5 -diphosphate (dCDP) in the presence of ATP or GTP. UMP and dCMP can also act as acceptors [ ]. | [
"GO:0005524",
"GO:0036431",
"GO:0006139"
] | [
"ATP binding",
"dCMP kinase activity",
"nucleobase-containing compound metabolic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_00238",
"TIGR00017"
] | [
"Cytidyl_kinase_type1",
"cmk"
] | [
24094,
23247
] | 2 | [
"EC",
"GP",
"GP",
"GP",
"METACYC"
] | [
"2.7.4.25",
"GenProp1369",
"GenProp1494",
"GenProp1634",
"PWY-7205"
] | [
"EC:2.7.4.25",
"GP:GenProp1369",
"GP:GenProp1494",
"GP:GenProp1634",
"METACYC:PWY-7205"
] | 5 | [
"1cke",
"1kdo",
"1kdp",
"1kdr",
"1kdt",
"1q3t",
"2cmk",
"2fem",
"2feo",
"2h92",
"3akc",
"3akd",
"3r20",
"3r8c",
"3w8n",
"3w90",
"4die",
"4e22",
"7ckj",
"7l4a"
] | 20 | [
"PUB00015310"
] | [
"9862805"
] | [
"Structures of escherichia coli CMP kinase alone and in complex with CDP: a new fold of the nucleoside monophosphate binding domain and insights into cytosine nucleotide specificity."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
23618,
214,
487
] | 3 | [
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica"
] | [
1,
1
] | 2 | true | Family | Cytidylate kinase | Cytidylate kinase | Cytidylate_kin | 4 |
IPR003138 | 3,138 | Picornavirus coat protein VP4 | Pico_P1A | Family | 19,799 | false | false | Picornaviruses are single-stranded RNA viruses. Processing of the viral polyprotein by picornains 3C and 2A generates capsid proteins VP0, VP1 and VP3, but VP0 undergoes an autolytic cleavage during virion assembly to generate capsid proteins VP2 and VP4 [ ]. The autolytic cleavage was originally thought to be the acti... | [
"GO:0005198",
"GO:0019028"
] | [
"structural molecule activity",
"viral capsid"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF02226"
] | [
"Pico_P1A"
] | [
19799
] | 1 | [
"EC",
"EC",
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.7.7.48",
"3.4.22.28",
"3.4.22.29",
"3.6.1.15",
"PWY-6545",
"PWY-7184",
"PWY-7185",
"PWY-7198",
"PWY-7210"
] | [
"EC:2.7.7.48",
"EC:3.4.22.28",
"EC:3.4.22.29",
"EC:3.6.1.15",
"METACYC:PWY-6545",
"METACYC:PWY-7184",
"METACYC:PWY-7185",
"METACYC:PWY-7198",
"METACYC:PWY-7210"
] | 9 | [
"1al2",
"1ar6",
"1ar7",
"1ar8",
"1ar9",
"1asj",
"1aym",
"1ayn",
"1bev",
"1c8m",
"1cov",
"1d3e",
"1d3i",
"1d4m",
"1dgi",
"1eah",
"1ev1",
"1fpn",
"1h8t",
"1hri",
"1hrv",
"1hxs",
"1jew",
"1k5m",
"1mqt",
"1na1",
"1ncq",
"1ncr",
"1nd2",
"1nd3",
"1nn8",
"1oop"... | 340 | [
"PUB00054231"
] | [
"6283126"
] | [
"Cleavage sites within the poliovirus capsid protein precursors."
] | [
1982
] | 1 | [] | [] | 0 | 0 | null | [
"Campylobacter jejuni",
"Opisthokonta",
"Picornavirales"
] | [
1,
6,
19792
] | 3 | [] | [] | 0 | true | Family | Picornavirus coat protein VP4 | Picornavirus coat protein VP4 | Pico_P1A | 3 |
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