interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR003290 | 3,290 | GPCR, family 2, glucagon-like peptide-1/glucagon receptor | GPCR_2_GLP1/glucagon_rcpt | Family | 1,541 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0004967",
"GO:0007186",
"GO:0016020"
] | [
"glucagon receptor activity",
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01353"
] | [
"GLUCAGNFAMLY"
] | [
1541
] | 1 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"249",
"R-HSA-163359",
"R-HSA-381676",
"R-HSA-416476",
"R-HSA-418555",
"R-HSA-420092",
"R-MMU-163359",
"R-MMU-381676",
"R-MMU-416476",
"R-MMU-418555",
"R-MMU-420092",
"R-RNO-163359",
"R-RNO-381676",
"R-RNO-416476",
"R-RNO-420092"
] | [
"IUPHAR:249",
"REACTOME:R-HSA-163359",
"REACTOME:R-HSA-381676",
"REACTOME:R-HSA-416476",
"REACTOME:R-HSA-418555",
"REACTOME:R-HSA-420092",
"REACTOME:R-MMU-163359",
"REACTOME:R-MMU-381676",
"REACTOME:R-MMU-416476",
"REACTOME:R-MMU-418555",
"REACTOME:R-MMU-420092",
"REACTOME:R-RNO-163359",
"RE... | 15 | [
"3c59",
"3c5t",
"3iol",
"4ers",
"4lf3",
"4zgm",
"5e94",
"5nx2",
"5ott",
"5otu",
"5otv",
"5otw",
"5otx",
"5vai",
"6b3j",
"6gb1",
"6lmk",
"6lml",
"6ln2",
"6orv",
"6vcb",
"6whc",
"6wpw",
"6x18",
"6x19",
"6x1a",
"6xox",
"7c2e",
"7fim",
"7ki0",
"7ki1",
"7lci"... | 60 | [
"PUB00001208",
"PUB00004310",
"PUB00004961",
"PUB00005147",
"PUB00005148",
"PUB00008074",
"PUB00008075",
"PUB00008076",
"PUB00008077",
"PUB00008078",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816"
] | [
"1646711",
"1314625",
"8170923",
"1658940",
"1658941",
"7590348",
"8384375",
"7517895",
"7843404",
"1326760",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293"
] | [
"Molecular cloning and expression of a cDNA encoding the secretin receptor.",
"Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide.",
"Fingerprinting G-protein-coupled receptors.",
"Expression cloning of an adenylate cyclase-coupled calcitonin receptor.",
... | [
1991,
1992,
1994,
1991,
1991,
1995,
1993,
1994,
1995,
1992,
2003,
1994,
2005,
2009,
2006,
2013
] | 16 | [
"IPR000832"
] | [
"IPR003291",
"IPR003292"
] | 1 | 2 | 0 | [
"Vertebrata"
] | [
1541
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
7,
8
] | 3 | true | Family | GPCR, family 2, glucagon-like peptide-1/glucagon receptor | GPCR, family 2, glucagon-like peptide-1/glucagon receptor | GPCR_2_GLP1/glucagon_rcpt | 9 |
IPR003292 | 3,292 | GPCR, family 2, glucagon-like peptide-1 receptor | GPCR_2_GLP1_rcpt | Family | 644 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0008528",
"GO:0007186",
"GO:0016020"
] | [
"G protein-coupled peptide receptor activity",
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01355"
] | [
"GLUCAGNLIKER"
] | [
644
] | 1 | [
"GP",
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"GenProp2092",
"249",
"R-HSA-381676",
"R-HSA-418555",
"R-HSA-420092",
"R-MMU-381676",
"R-MMU-418555",
"R-MMU-420092",
"R-RNO-381676",
"R-RNO-420092"
] | [
"GP:GenProp2092",
"IUPHAR:249",
"REACTOME:R-HSA-381676",
"REACTOME:R-HSA-418555",
"REACTOME:R-HSA-420092",
"REACTOME:R-MMU-381676",
"REACTOME:R-MMU-418555",
"REACTOME:R-MMU-420092",
"REACTOME:R-RNO-381676",
"REACTOME:R-RNO-420092"
] | 10 | [
"3c59",
"3c5t",
"3iol",
"4zgm",
"5e94",
"5nx2",
"5ott",
"5otu",
"5otv",
"5otw",
"5otx",
"5vai",
"6b3j",
"6gb1",
"6ln2",
"6orv",
"6vcb",
"6x18",
"6x19",
"6x1a",
"6xox",
"7c2e",
"7fim",
"7ki0",
"7ki1",
"7lci",
"7lcj",
"7lck",
"7lll",
"7lly",
"7rg9",
"7rgp"... | 45 | [
"PUB00001208",
"PUB00004310",
"PUB00004961",
"PUB00005147",
"PUB00005148",
"PUB00008076",
"PUB00008077",
"PUB00008078",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816",
"PUB00101674"
] | [
"1646711",
"1314625",
"8170923",
"1658940",
"1658941",
"7517895",
"7843404",
"1326760",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293",
"28514449"
] | [
"Molecular cloning and expression of a cDNA encoding the secretin receptor.",
"Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide.",
"Fingerprinting G-protein-coupled receptors.",
"Expression cloning of an adenylate cyclase-coupled calcitonin receptor.",
... | [
1991,
1992,
1994,
1991,
1991,
1994,
1995,
1992,
2003,
1994,
2005,
2009,
2006,
2013,
2017
] | 15 | [
"IPR003290"
] | [] | 1 | 0 | 1 | [
"Tetrapoda"
] | [
644
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
4,
5
] | 3 | true | Family | GPCR, family 2, glucagon-like peptide-1 receptor | GPCR, family 2, glucagon-like peptide-1 receptor | GPCR_2_GLP1_rcpt | 2 |
IPR003293 | 3,293 | Nudix hydrolase 6-like | Nudix_hydrolase6-like | Family | 6,012 | false | false | This entry represents several nudix hydrolases, including nudix hydrolase 2, 5, 6, 7, 8 and 10. Nudix hydrolases are ubiquitous proteins that hydrolyse a wide range of organic pyrophosphates, including nucleoside di- and triphosphates, dinucleoside and diphosphoinositol polyphosphates, nucleotide sugars and RNA caps, w... | [] | [] | [] | 0 | [
"PRINTS",
"PANTHER"
] | [
"PR01356",
"PTHR13994"
] | [
"GFGPROTEIN",
""
] | [
4661,
5961
] | 2 | [
"EC",
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"3.6.1",
"3.6.1.-",
"3.6.1.22",
"PWY-5381",
"PWY-5757",
"PWY-6147",
"PWY-6383",
"PWY-6797",
"PWY-7206",
"PWY-7419",
"PWY-7539",
"PWY-7719",
"PWY-7761",
"PWY-7821",
"PWY-8289"
] | [
"EC:3.6.1",
"EC:3.6.1.-",
"EC:3.6.1.22",
"METACYC:PWY-5381",
"METACYC:PWY-5757",
"METACYC:PWY-6147",
"METACYC:PWY-6383",
"METACYC:PWY-6797",
"METACYC:PWY-7206",
"METACYC:PWY-7419",
"METACYC:PWY-7539",
"METACYC:PWY-7719",
"METACYC:PWY-7761",
"METACYC:PWY-7821",
"METACYC:PWY-8289"
] | 15 | [
"3fxt",
"3h95",
"4zb3",
"4zbp"
] | 4 | [
"PUB00034750",
"PUB00046145"
] | [
"16378245",
"18799520"
] | [
"The Nudix hydrolase superfamily.",
"The nudix hydrolase 7 is an Acyl-CoA diphosphatase involved in regulating peroxisomal coenzyme A homeostasis."
] | [
2006,
2008
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"ecological metagenomes"
] | [
289,
5705,
6,
12
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
54,
1,
2,
2,
9,
8,
8,
26
] | 8 | true | Family | Nudix hydrolase 6-like | Nudix hydrolase 6-like | Nudix_hydrolase6-like | 6 |
IPR003295 | 3,295 | Interleukin-1 alpha | IL-1_alpha | Family | 263 | false | false | Interleukin-1 alpha and interleukin-1 beta (IL-1 alpha and IL-1 beta) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis [ ]. Two types of IL-1 receptor, each with three extracellular immunoglobulin (Ig)-like domains, limited sequence similarity (28%) and dif... | [
"GO:0005149",
"GO:0006954",
"GO:0006955",
"GO:0005576"
] | [
"interleukin-1 receptor binding",
"inflammatory response",
"immune response",
"extracellular region"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PRINTS"
] | [
"PR01358"
] | [
"INTRLEUKIN1A"
] | [
263
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-448706",
"R-BTA-5620971",
"R-BTA-9020702",
"R-HSA-2559582",
"R-HSA-448706",
"R-HSA-5620971",
"R-HSA-6783783",
"R-HSA-6785807",
"R-HSA-9020702",
"R-HSA-9660826",
"R-MMU-448706",
"R-MMU-5620971",
"R-MMU-9020702",
"R-RNO-448706",
"R-RNO-5620971",
"R-RNO-9020702",
"R-SSC-448706",
... | [
"REACTOME:R-BTA-448706",
"REACTOME:R-BTA-5620971",
"REACTOME:R-BTA-9020702",
"REACTOME:R-HSA-2559582",
"REACTOME:R-HSA-448706",
"REACTOME:R-HSA-5620971",
"REACTOME:R-HSA-6783783",
"REACTOME:R-HSA-6785807",
"REACTOME:R-HSA-9020702",
"REACTOME:R-HSA-9660826",
"REACTOME:R-MMU-448706",
"REACTOME:R... | 19 | [
"2ila",
"2kki",
"2l5x",
"5uc6"
] | 4 | [
"PUB00003281",
"PUB00004697",
"PUB00007346",
"PUB00007347",
"PUB00007348",
"PUB00007349",
"PUB00007350"
] | [
"1738162",
"2602367",
"2969618",
"8702856",
"1833184",
"1826022",
"1339315"
] | [
"beta-Trefoil fold. Patterns of structure and sequence in the Kunitz inhibitors interleukins-1 beta and 1 alpha and fibroblast growth factors.",
"Crystallographic refinement of interleukin 1 beta at 2.0 A resolution.",
"cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily.",
... | [
1992,
1989,
1988,
1996,
1991,
1991,
1992
] | 7 | [] | [] | 0 | 0 | null | [
"Mammalia"
] | [
263
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
7
] | 3 | true | Family | Interleukin-1 alpha | Interleukin-1 alpha | IL-1_alpha | 4 |
IPR003297 | 3,297 | Interleukin-1 receptor antagonist/Interleukin-36 | IL-1RA/IL-36 | Family | 1,543 | false | false | This entry represents IL-1RA and Interleukin-36 cytokines. Interleukin-1 receptor antagonist (IL-1RA) binds to the IL-1 receptor, blocking the effects of Interleukin-1 alpha and interleukin-1 beta (IL-1A and IL-1B), whilst eliciting no response of its own. From sequence comparisons, it seems to have arisen by gene dupl... | [
"GO:0005149"
] | [
"interleukin-1 receptor binding"
] | [
"molecular_function"
] | 1 | [
"PRINTS"
] | [
"PR01360"
] | [
"INTRLEUKIN1X"
] | [
1543
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CFA-9020702",
"R-HSA-6783783",
"R-HSA-9007892",
"R-HSA-9008059",
"R-HSA-9012546",
"R-HSA-9014826",
"R-HSA-9020702",
"R-MMU-9007892",
"R-MMU-9014826",
"R-MMU-9020702",
"R-RNO-9020702"
] | [
"REACTOME:R-CFA-9020702",
"REACTOME:R-HSA-6783783",
"REACTOME:R-HSA-9007892",
"REACTOME:R-HSA-9008059",
"REACTOME:R-HSA-9012546",
"REACTOME:R-HSA-9014826",
"REACTOME:R-HSA-9020702",
"REACTOME:R-MMU-9007892",
"REACTOME:R-MMU-9014826",
"REACTOME:R-MMU-9020702",
"REACTOME:R-RNO-9020702"
] | 11 | [
"1ilr",
"1ilt",
"1ira",
"1irp",
"1md6",
"2irt",
"4ize",
"4p0j",
"4p0k",
"4p0l",
"5bow",
"5hn1",
"6ncu",
"6p9e",
"8q3j"
] | 15 | [
"PUB00004748",
"PUB00007346",
"PUB00007347",
"PUB00063065",
"PUB00063066",
"PUB00063078",
"PUB00063092",
"PUB00063093"
] | [
"1828896",
"2969618",
"8702856",
"23029241",
"20959797",
"14734551",
"17908936",
"20935647"
] | [
"Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism.",
"cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily.",
"Cloning and characterization of an alternatively processed human type II interleukin-1 recep... | [
1991,
1988,
1996,
2012,
2010,
2004,
2007,
2010
] | 8 | [
"IPR000975"
] | [] | 1 | 0 | 1 | [
"Amniota",
"Cervidpoxvirus"
] | [
1538,
5
] | 2 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
12,
15
] | 3 | true | Family | Interleukin-1 receptor antagonist/Interleukin-36 | Interleukin-1 receptor antagonist/Interleukin-36 | IL-1RA/IL-36 | 3 |
IPR003298 | 3,298 | Apical membrane antigen 1 | Apmem_Ag1 | Family | 4,046 | false | false | A novel antigen of Plasmodium falciparum has been cloned that contains a hydrophobic domain typical of an integral membrane protein. The antigen is designated apical membrane antigen 1 (AMA-1) by virtue of appearing to be located in the apical complex [ ]. AMA-1 appears to be transported to the merozoite surface close ... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PFAM",
"PRINTS",
"SMART"
] | [
"PF02430",
"PR01361",
"SM00815"
] | [
"AMA-1",
"MEROZOITESA",
"AMA-1"
] | [
4045,
3840,
3423
] | 3 | [] | [] | [] | 0 | [
"1hn6",
"1w81",
"1w8k",
"1yxe",
"1z40",
"2j4w",
"2j5l",
"2mtx",
"2q8a",
"2q8b",
"2x2z",
"2y8r",
"2y8s",
"2y8t",
"2z8v",
"2z8w",
"3sri",
"3srj",
"3zld",
"3zle",
"3zwz",
"4apl",
"4apm",
"4r19",
"4r1a",
"4r1b",
"4r1c",
"4uao",
"4uv6",
"4yiv",
"4yiz",
"4z09"... | 53 | [
"PUB00008080",
"PUB00008081"
] | [
"2701947",
"2211675"
] | [
"Integral membrane protein located in the apical complex of Plasmodium falciparum.",
"A merozoite receptor protein from Plasmodium knowlesi is highly conserved and distributed throughout Plasmodium."
] | [
1989,
1990
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pedobacter cryoconitis"
] | [
4045,
1
] | 2 | [] | [] | 0 | true | Family | Apical membrane antigen 1 | Apical membrane antigen 1 | Apmem_Ag1 | 2 |
IPR003299 | 3,299 | Flagellar calcium-binding protein calflagin | Calflagin-bd | Family | 442 | false | false | null | [
"GO:0005509"
] | [
"calcium ion binding"
] | [
"molecular_function"
] | 1 | [
"PRINTS"
] | [
"PR01362"
] | [
"CALFLAGIN"
] | [
442
] | 1 | [] | [] | [] | 0 | [
"1bod",
"2ami",
"2lvv",
"3cs1"
] | 4 | [
"PUB00008082",
"PUB00008083"
] | [
"2681200",
"7818488"
] | [
"A novel flagellar Ca2+-binding protein in trypanosomes.",
"The gene family of EF-hand calcium-binding proteins from the flagellum of Trypanosoma brucei."
] | [
1989,
1994
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
8,
434
] | 2 | [
"Oryza sativa subsp. japonica"
] | [
2
] | 1 | true | Family | Flagellar calcium-binding protein calflagin | Flagellar calcium-binding protein calflagin | Calflagin-bd | 6 |
IPR003300 | 3,300 | Viral protein D9 | Viral_VD9 | Family | 100 | false | false | The complete DNA sequence of the genome of Vaccinia virus has been determined [ ]. 198 "major" protein-coding regions and 65 overlapping "minor" regions have been identified, with a total of 263 potential genes. The genes are compactly organised along the genome, with few noncoding regions [ ]. The function of the majo... | [
"GO:0016787"
] | [
"hydrolase activity"
] | [
"molecular_function"
] | 1 | [
"PRINTS"
] | [
"PR01363"
] | [
"VD09PROTEIN"
] | [
100
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"3.1.3.-",
"PWY-4702",
"PWY-5491",
"PWY-6148",
"PWY-6352",
"PWY-6365",
"PWY-6366",
"PWY-6368",
"PWY-6456",
"PWY-6575",
"PWY-6627",
"PWY-6664",
"PWY-6686",
"PWY-6720",
"PWY-6724",
"PWY-6955",
"PWY-6990",
"PWY-6991",
"PWY-7018",
"PWY-7119",
"PWY-7321",
"PWY-7531",
"PWY-7771... | [
"EC:3.1.3.-",
"METACYC:PWY-4702",
"METACYC:PWY-5491",
"METACYC:PWY-6148",
"METACYC:PWY-6352",
"METACYC:PWY-6365",
"METACYC:PWY-6366",
"METACYC:PWY-6368",
"METACYC:PWY-6456",
"METACYC:PWY-6575",
"METACYC:PWY-6627",
"METACYC:PWY-6664",
"METACYC:PWY-6686",
"METACYC:PWY-6720",
"METACYC:PWY-6... | 36 | [
"7sez",
"7sf0",
"7t7h"
] | 3 | [
"PUB00008084",
"PUB00103561",
"PUB00103562"
] | [
"2219722",
"35290794",
"17881455"
] | [
"The complete DNA sequence of vaccinia virus.",
"Structure of the poxvirus decapping enzyme D9 reveals its mechanism of cap recognition and catalysis.",
"Characterization of a second vaccinia virus mRNA-decapping enzyme conserved in poxviruses."
] | [
1990,
2022,
2007
] | 3 | [] | [] | 0 | 0 | null | [
"Chordopoxvirinae"
] | [
100
] | 1 | [] | [] | 0 | true | Family | Viral protein D9 | Viral protein D9 | Viral_VD9 | 9 |
IPR003301 | 3,301 | Vaccinia virus D10, decapping enzyme | Vaccinia_D10_decapping | Family | 118 | false | false | The complete DNA sequence of the genome of Vaccinia virus has been determined [ ]. 198 "major" protein-coding regions and 65 overlapping "minor" regions have been identified, with a total of 263 potential genes. The genes are compactly organised along the genome, with few noncoding regions [ ]. The function of the majo... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR01364"
] | [
"VD10PROTEIN"
] | [
118
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"3.1.3.-",
"PWY-4702",
"PWY-5491",
"PWY-6148",
"PWY-6352",
"PWY-6365",
"PWY-6366",
"PWY-6368",
"PWY-6456",
"PWY-6575",
"PWY-6627",
"PWY-6664",
"PWY-6686",
"PWY-6720",
"PWY-6724",
"PWY-6955",
"PWY-6990",
"PWY-6991",
"PWY-7018",
"PWY-7119",
"PWY-7321",
"PWY-7531",
"PWY-7771... | [
"EC:3.1.3.-",
"METACYC:PWY-4702",
"METACYC:PWY-5491",
"METACYC:PWY-6148",
"METACYC:PWY-6352",
"METACYC:PWY-6365",
"METACYC:PWY-6366",
"METACYC:PWY-6368",
"METACYC:PWY-6456",
"METACYC:PWY-6575",
"METACYC:PWY-6627",
"METACYC:PWY-6664",
"METACYC:PWY-6686",
"METACYC:PWY-6720",
"METACYC:PWY-6... | 36 | [] | 0 | [
"PUB00006662",
"PUB00008084",
"PUB00008085"
] | [
"8810257",
"2219722",
"2177083"
] | [
"The MutT proteins or \"Nudix\" hydrolases, a family of versatile, widely distributed, \"housecleaning\" enzymes.",
"The complete DNA sequence of vaccinia virus.",
"Analysis of the fowlpox virus genome region corresponding to the vaccinia virus D6 to A1 region: location of, and variation in, non-essential genes... | [
1996,
1990,
1990
] | 3 | [] | [] | 0 | 0 | null | [
"Nucleocytoviricota"
] | [
118
] | 1 | [] | [] | 0 | true | Family | Vaccinia virus D10, decapping enzyme | Vaccinia virus D10, decapping enzyme | Vaccinia_D10_decapping | 4 |
IPR003303 | 3,303 | Filaggrin | Filaggrin | Family | 190 | false | false | Filaggrins are filament-associated proteins that interact with keratin intermediate filaments of terminally differentiating mammalian epidermis via disulphide bond formation [ , ]. Filaggrin-2 is essential for normal cell-cell adhesion in the cornified cell layers and important for proper integrity and mechanical stren... | [
"GO:0005198"
] | [
"structural molecule activity"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PRINTS"
] | [
"PF03516",
"PR00487"
] | [
"Filaggrin",
"FILAGGRIN"
] | [
171,
99
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6798695",
"R-HSA-6809371",
"R-HSA-9725554"
] | [
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-6809371",
"REACTOME:R-HSA-9725554"
] | 3 | [] | 0 | [
"PUB00004684",
"PUB00098649"
] | [
"2740331",
"29758285"
] | [
"Characterization of a cDNA clone encoding human filaggrin and localization of the gene to chromosome region 1q21.",
"Filaggrin 2 Deficiency Results in Abnormal Cell-Cell Adhesion in the Cornified Cell Layers and Causes Peeling Skin Syndrome Type A."
] | [
1989,
2018
] | 2 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
190
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
17,
5,
2
] | 3 | true | Family | Filaggrin | Filaggrin | Filaggrin | 5 |
IPR003304 | 3,304 | Prostanoid EP3 receptor, type 1 | EP3_rcpt_1 | Family | 65 | false | false | null | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR00583"
] | [
"PRSTNOIDE31R"
] | [
65
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-BTA-391908",
"R-BTA-418594"
] | [
"REACTOME:R-BTA-391908",
"REACTOME:R-BTA-418594"
] | 2 | [] | 0 | [
"PUB00000131",
"PUB00002477",
"PUB00004960",
"PUB00004961",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816"
] | [
"2111655",
"2830256",
"8386361",
"8170923",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293"
] | [
"G proteins in signal transduction.",
"G protein involvement in receptor-effector coupling.",
"Design of a discriminating fingerprint for G-protein-coupled receptors.",
"Fingerprinting G-protein-coupled receptors.",
"The G protein-coupled receptor repertoires of human and mouse.",
"GCRDb: a G-protein-coup... | [
1990,
1988,
1993,
1994,
2003,
1994,
2005,
2009,
2006,
2013
] | 10 | [
"IPR000265"
] | [] | 1 | 0 | 1 | [
"Pecora"
] | [
65
] | 1 | [] | [] | 0 | true | Family | Prostanoid EP3 receptor, type 1 | Prostanoid EP3 receptor, type 1 | EP3_rcpt_1 | 9 |
IPR003305 | 3,305 | Carbohydrate-binding, CenC-like | CenC_carb-bd | Domain | 15,175 | false | false | The 1,4-beta-glucanase CenC from Cellulomonas fimi ( ) contains two cellulose-binding domains, CBD(N1) and CBD(N2), arranged in tandem at its N terminus. These homologous CBDs are distinct in their selectivity for binding amorphous and not crystalline cellulose [ ]. Multidimensional heteronuclear nuclear magnetic reson... | [
"GO:0016798"
] | [
"hydrolase activity, acting on glycosyl bonds"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF02018"
] | [
"CBM_4_9"
] | [
15175
] | 1 | [
"EC"
] | [
"3.2.1"
] | [
"EC:3.2.1"
] | 1 | [
"1cx1",
"1dyo",
"1gu3",
"1gui",
"1h6x",
"1h6y",
"1k42",
"1k45",
"1ulo",
"1ulp",
"2w5f",
"2wys",
"2wze",
"2y64",
"2y6g",
"2y6h",
"2y6j",
"2y6k",
"2y6l",
"2zew",
"2zex",
"2zey",
"2zez",
"3jxs",
"3k4z",
"3oea",
"3oeb",
"3p6b",
"4bj0",
"4mgq",
"4q8k",
"4xun"... | 45 | [
"PUB00008087",
"PUB00008088",
"PUB00154348",
"PUB00154349"
] | [
"10704194",
"8916925",
"21543854",
"26001782"
] | [
"Structure and binding specificity of the second N-terminal cellulose-binding domain from Cellulomonas fimi endoglucanase C.",
"Structure of the N-terminal cellulose-binding domain of Cellulomonas fimi CenC determined by nuclear magnetic resonance spectroscopy.",
"Structure of CBM4 from Clostridium thermocellum... | [
2000,
1996,
2011,
2015
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
37,
11508,
3442,
106,
82
] | 5 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
34,
16,
25
] | 3 | true | Domain | Carbohydrate-binding, CenC-like | Carbohydrate-binding, CenC-like | CenC_carb-bd | 3 |
IPR003306 | 3,306 | WIF domain | WIF | Domain | 3,906 | false | false | Wnt morphogens control embryonic development and homeostasis in adult tissues. In vertebrates the N-terminal WIF domain (WIF-1WD) of Wnt inhibitory factor 1 (WIF-1) binds Wnt ligands. This entry represents the WIF domain, it is found in the RYK tyrosine kinase receptors and WIF the Wnt-inhibitory-factor. The domain is ... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF02019",
"PS50814",
"SM00469"
] | [
"WIF",
"WIF",
"WIF"
] | [
3705,
3893,
3471
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC50814",
"R-DME-201681",
"R-HSA-201681",
"R-HSA-3772470",
"R-HSA-4086400",
"R-MMU-201681"
] | [
"PROSITEDOC:PDOC50814",
"REACTOME:R-DME-201681",
"REACTOME:R-HSA-201681",
"REACTOME:R-HSA-3772470",
"REACTOME:R-HSA-4086400",
"REACTOME:R-MMU-201681"
] | 6 | [
"2d3j",
"2ygn",
"2ygo",
"2ygp",
"2ygq",
"7me5"
] | 6 | [
"PUB00008089",
"PUB00059810"
] | [
"10637605",
"21743455"
] | [
"The WIF module.",
"Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1."
] | [
2000,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"Methanoculleus nereidis",
"marine metagenome"
] | [
82,
3,
3819,
1,
1
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
5,
9,
5,
7,
9
] | 6 | true | Domain | WIF domain | WIF domain | WIF | 4 |
IPR003307 | 3,307 | W2 domain | W2_domain | Domain | 24,055 | false | false | Translation initiation is a sophisticated, well regulated and highly coordinated cellular process in eukaryotes, in which at least 11 eukaryotic initiation factors (eIFs) are included. The W2 domain (two invariant tryptophans) is a region of ~165 amino acids which is found in the C terminus of the following eIFs [ , , ... | [
"GO:0005515"
] | [
"protein binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF02020",
"PS51363",
"SM00515"
] | [
"W2",
"W2",
"eIF5C"
] | [
22721,
23973,
21857
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-72702",
"R-DDI-72702",
"R-DDI-72731",
"R-DME-72702",
"R-HSA-1169408",
"R-HSA-156827",
"R-HSA-166208",
"R-HSA-429947",
"R-HSA-450408",
"R-HSA-72649",
"R-HSA-72662",
"R-HSA-72702",
"R-HSA-72706",
"R-HSA-72731",
"R-HSA-9010553",
"R-HSA-975956",
"R-HSA-975957",
"R-HSA-9820841",
... | [
"REACTOME:R-CEL-72702",
"REACTOME:R-DDI-72702",
"REACTOME:R-DDI-72731",
"REACTOME:R-DME-72702",
"REACTOME:R-HSA-1169408",
"REACTOME:R-HSA-156827",
"REACTOME:R-HSA-166208",
"REACTOME:R-HSA-429947",
"REACTOME:R-HSA-450408",
"REACTOME:R-HSA-72649",
"REACTOME:R-HSA-72662",
"REACTOME:R-HSA-72702",
... | 38 | [
"1paq",
"1ug3",
"2ful",
"2iu1",
"3d3m",
"3jui",
"3l6a",
"5b04",
"6caj",
"6ezo",
"6fyx",
"6fyy",
"6i3m",
"6i7t",
"6jly",
"6jlz",
"6k71",
"6k72",
"6knd",
"6kne",
"6o81",
"6o85",
"6o9z",
"6qg0",
"6qg1",
"6qg2",
"6qg3",
"6qg5",
"6qg6",
"6zmw",
"6zu9",
"7ase"... | 53 | [
"PUB00005748",
"PUB00022408",
"PUB00035800",
"PUB00040819",
"PUB00041778"
] | [
"8520487",
"14681227",
"10958635",
"16616930",
"16781736"
] | [
"Multidomain organization of eukaryotic guanine nucleotide exchange translation initiation factor eIF-2B subunits revealed by analysis of conserved sequence motifs.",
"Structure of the catalytic fragment of translation initiation factor 2B and identification of a critically important catalytic residue.",
"Eukar... | [
1995,
2004,
2000,
2006,
2006
] | 5 | [] | [
"IPR043510",
"IPR044123"
] | 0 | 2 | 0 | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
5,
24043,
4,
3
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
31,
2,
82,
11,
46,
35,
2,
17,
39,
2,
2,
35
] | 12 | true | Domain | W2 domain | W2 domain | W2_domain | 4 |
IPR003308 | 3,308 | Integrase, N-terminal zinc-binding domain | Integrase_Zn-bd_dom_N | Domain | 59,407 | false | false | Retroviral integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains: an N-terminal zinc binding domain, a central catalytic core and a C-terminal DNA-binding domain [ , ]. Often found as part of the POL polyprotein. | [
"GO:0008270"
] | [
"zinc ion binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE"
] | [
"PF02022",
"PS50876"
] | [
"Integrase_Zn",
"ZF_INTEGRASE"
] | [
59208,
58967
] | 2 | [
"EC",
"EC",
"EC",
"EC",
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"RE... | [
"2.7.7.-",
"2.7.7.49",
"2.7.7.7",
"3.1.13.2",
"3.1.26.13",
"3.4.23",
"PWY-6322",
"PWY-6626",
"PWY-6749",
"PWY-6955",
"PWY-6998",
"PWY-7127",
"PWY-7419",
"PWY-7529",
"PWY-7706",
"PWY-7719",
"PWY-7735",
"PWY-7737",
"PWY-7769",
"PWY-7888",
"PWY-7904",
"PWY-8117",
"PWY-8179",... | [
"EC:2.7.7.-",
"EC:2.7.7.49",
"EC:2.7.7.7",
"EC:3.1.13.2",
"EC:3.1.26.13",
"EC:3.4.23",
"METACYC:PWY-6322",
"METACYC:PWY-6626",
"METACYC:PWY-6749",
"METACYC:PWY-6955",
"METACYC:PWY-6998",
"METACYC:PWY-7127",
"METACYC:PWY-7419",
"METACYC:PWY-7529",
"METACYC:PWY-7706",
"METACYC:PWY-7719",... | 37 | [
"1e0e",
"1k6y",
"1wja",
"1wjb",
"1wjc",
"1wjd",
"1wje",
"1wjf",
"3f9k",
"3hpg",
"3hph",
"3jca",
"4fw2",
"5cz2",
"5ejk",
"5m0r",
"5u1c",
"6put",
"6puw",
"6puy",
"6puz",
"6rwl",
"6rwm",
"6rwn",
"6rwo",
"6u8q",
"6v3k",
"6vdk",
"6voy",
"6vrg",
"7jn3",
"7ku7"... | 65 | [
"PUB00024383",
"PUB00026646"
] | [
"11101216",
"11743009"
] | [
"Refined solution structure of the dimeric N-terminal HHCC domain of HIV-2 integrase.",
"Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein."
] | [
2000,
2001
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Retroviridae",
"bird metagenome"
] | [
7,
2800,
56599,
1
] | 4 | [
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus"
] | [
15,
15,
3,
1
] | 4 | true | Domain | Integrase, N-terminal zinc-binding domain | Integrase, N-terminal zinc-binding domain | Integrase_Zn-bd_dom_N | 9 |
IPR003309 | 3,309 | SCAN domain | SCAN_dom | Domain | 22,092 | false | false | A number of C2H2-zinc finger proteins contain a highly conserved N-terminal motif termed the SCAN (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) domain. The SCAN domain has been shown to be able to mediate homo- and hetero-oligomerisation [ ]. These proteins can either activate or repress transcription, althou... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART",
"CDD"
] | [
"PF02023",
"PS50804",
"SM00431",
"cd07936"
] | [
"SCAN",
"SCAN_BOX",
"SCAN",
"SCAN"
] | [
21391,
20463,
18050,
15419
] | 4 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC50804",
"R-BTA-212436",
"R-HSA-212436",
"R-HSA-452723",
"R-HSA-9819196",
"R-MMU-212436",
"R-RNO-212436"
] | [
"PROSITEDOC:PDOC50804",
"REACTOME:R-BTA-212436",
"REACTOME:R-HSA-212436",
"REACTOME:R-HSA-452723",
"REACTOME:R-HSA-9819196",
"REACTOME:R-MMU-212436",
"REACTOME:R-RNO-212436"
] | 7 | [
"1y7q",
"2fi2",
"3lhr",
"4bhx",
"4e6s"
] | 5 | [
"PUB00008090",
"PUB00018272",
"PUB00018273",
"PUB00018274",
"PUB00018275",
"PUB00032595"
] | [
"10567577",
"8065901",
"7673192",
"10393183",
"10747874",
"15629724"
] | [
"The zinc finger-associated SCAN box is a conserved oligomerization domain.",
"Repression of transcriptional activity at a distance by the evolutionarily conserved KRAB domain present in a subfamily of zinc finger proteins.",
"Isolation and characterization of a novel zinc-finger protein with transcription repr... | [
1999,
1994,
1995,
1999,
2000,
2005
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"invertebrate metagenome"
] | [
60,
22031,
1
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
79,
225,
133,
109
] | 4 | true | Domain | SCAN domain | SCAN domain | SCAN_dom | 2 |
IPR003310 | 3,310 | G/T mismatch-specific thymine DNA glycosylasee TDG-like, eukaryotes | TDG-like_euk | Family | 810 | false | false | This entry includes a group of eukaryotic G/U mismatch-specific DNA glycosylases, including the uracil DNA glycosylase from fission yeasts and the thymine DNA glycosylase from animals. They excise the mismatched base from G:X mismatches, where X is uracil, thymine or 5-hydroxymethyluracil (5hmU). The mammalian thymine ... | [
"GO:0000700",
"GO:0006285"
] | [
"mismatch base pair DNA N-glycosylase activity",
"base-excision repair, AP site formation"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00584"
] | [
"mug"
] | [
810
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-110328",
"R-HSA-110329",
"R-HSA-110357",
"R-HSA-3108214",
"R-HSA-5221030",
"R-MMU-110329",
"R-MMU-110357",
"R-MMU-3108214",
"R-MMU-5221030",
"R-SPO-110329",
"R-SPO-3108214",
"R-SPO-5221030"
] | [
"REACTOME:R-HSA-110328",
"REACTOME:R-HSA-110329",
"REACTOME:R-HSA-110357",
"REACTOME:R-HSA-3108214",
"REACTOME:R-HSA-5221030",
"REACTOME:R-MMU-110329",
"REACTOME:R-MMU-110357",
"REACTOME:R-MMU-3108214",
"REACTOME:R-MMU-5221030",
"REACTOME:R-SPO-110329",
"REACTOME:R-SPO-3108214",
"REACTOME:R-SP... | 12 | [
"1wyw",
"2d07",
"2rba",
"3ufj",
"3uo7",
"3uob",
"4fnc",
"4jgc",
"4xeg",
"4z3a",
"4z47",
"4z7b",
"4z7z",
"5cys",
"5ff8",
"5hf7",
"5jxy",
"5t2w",
"6u15",
"6u16",
"6u17"
] | 21 | [
"PUB00008091",
"PUB00078846",
"PUB00078847",
"PUB00078848",
"PUB00078849",
"PUB00080609",
"PUB00095804"
] | [
"9489705",
"22962365",
"22327402",
"18945672",
"21722948",
"19909758",
"18789404"
] | [
"Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions.",
"Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation.",
"Thymine DNA glycos... | [
1998,
2012,
2012,
2008,
2011,
2010,
2008
] | 7 | [
"IPR015637"
] | [] | 1 | 0 | 1 | [
"Opisthokonta"
] | [
810
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
6,
2,
7,
1
] | 5 | true | Family | G/T mismatch-specific thymine DNA glycosylasee TDG-like, eukaryotes | G/T mismatch-specific thymine DNA glycosylasee TDG-like, eukaryotes | TDG-like_euk | 5 |
IPR003311 | 3,311 | AUX/IAA protein | AUX_IAA | Family | 15,721 | false | false | The Aux/IAA proteins are key regulators of auxin-modulated gene expression [ ]. The plant hormone auxin (indole-3-acetic acid, IAA) regulates diverse cellular and developmental responses in plants, including cell division, expansion, differentiation and patterning of embryo responses [ ]. Auxin can regulate the gene ex... | [
"GO:0006355",
"GO:0005634"
] | [
"regulation of DNA-templated transcription",
"nucleus"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PANTHER"
] | [
"PTHR31734"
] | [
""
] | [
15721
] | 1 | [] | [] | [] | 0 | [
"2m1m",
"2muk",
"6l5k"
] | 3 | [
"PUB00008092",
"PUB00014762",
"PUB00014763",
"PUB00014766"
] | [
"9482737",
"15061689",
"11544131",
"12036262"
] | [
"The Arabidopsis gene MONOPTEROS encodes a transcription factor mediating embryo axis formation and vascular development.",
"Recent advances in the study of mechanisms of action of phytohormones.",
"Roles and activities of Aux/IAA proteins in Arabidopsis.",
"Genetics of Aux/IAA and ARF action in plant growth ... | [
1998,
2004,
2001,
2002
] | 4 | [] | [] | 0 | 0 | null | [
"Escherichia coli",
"Eukaryota"
] | [
1,
15720
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
395,
56,
210
] | 3 | true | Family | AUX/IAA protein | AUX/IAA protein | AUX_IAA | 7 |
IPR003313 | 3,313 | AraC-type arabinose-binding/dimerisation domain | AraC-bd | Domain | 86,723 | false | false | This entry defines the ligand-binding and dimerisation domain of the bacterial regulatory protein AraC and other HTH-type transcriptional regulators. The crystal structure of the arabinose-binding and dimerisation domain of the Escherichia coli gene regulatory protein AraC was determined in the presence and absence of ... | [
"GO:0006355"
] | [
"regulation of DNA-templated transcription"
] | [
"biological_process"
] | 1 | [
"PFAM"
] | [
"PF02311"
] | [
"AraC_binding"
] | [
86723
] | 1 | [] | [] | [] | 0 | [
"1xja",
"2aac",
"2ara",
"2arc",
"5u93",
"5u9e",
"6nwh",
"6nwj",
"6nwm",
"6nwo",
"6nx3"
] | 11 | [
"PUB00008093"
] | [
"9103202"
] | [
"Structural basis for ligand-regulated oligomerization of AraC."
] | [
1997
] | 1 | [] | [
"IPR047220"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"Sym plasmid",
"unclassified sequences"
] | [
25,
86314,
5,
119,
1,
259
] | 6 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)"
] | [
1,
5
] | 2 | true | Domain | AraC-type arabinose-binding/dimerisation domain | AraC-type arabinose-binding/dimerisation domain | AraC-bd | 5 |
IPR003316 | 3,316 | E2F/DP family, winged-helix DNA-binding domain | E2F_WHTH_DNA-bd_dom | Domain | 19,819 | false | false | This entry represents the DNA-binding domain of the E2F and DP proteins, which have a fold related to the winged-helix DNA-binding motif [ ]. The mammalian transcription factor E2F plays an important role in regulating the expression of genes that are required for passage through the cell cycle. Multiple E2F family mem... | [
"GO:0006355",
"GO:0005667"
] | [
"regulation of DNA-templated transcription",
"transcription regulator complex"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"SMART"
] | [
"PF02319",
"SM01372"
] | [
"WHD_E2F_TDP",
"E2F_TDP"
] | [
19715,
19705
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1538133",
"R-BTA-2173796",
"R-BTA-69231",
"R-BTA-8953750",
"R-CEL-1538133",
"R-CEL-2173796",
"R-DDI-913709",
"R-DME-1538133",
"R-DME-2173796",
"R-DME-68911",
"R-DME-69231",
"R-DME-8953750",
"R-DRE-6804116",
"R-HSA-111448",
"R-HSA-113501",
"R-HSA-1362277",
"R-HSA-1362300",
"R... | [
"REACTOME:R-BTA-1538133",
"REACTOME:R-BTA-2173796",
"REACTOME:R-BTA-69231",
"REACTOME:R-BTA-8953750",
"REACTOME:R-CEL-1538133",
"REACTOME:R-CEL-2173796",
"REACTOME:R-DDI-913709",
"REACTOME:R-DME-1538133",
"REACTOME:R-DME-2173796",
"REACTOME:R-DME-68911",
"REACTOME:R-DME-69231",
"REACTOME:R-DME... | 44 | [
"1cf7",
"4yo2"
] | 2 | [
"PUB00008097",
"PUB00019485"
] | [
"7739537",
"10090723"
] | [
"In vivo association of E2F and DP family proteins.",
"Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP."
] | [
1995,
1999
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Odinarchaeota yellowstonii (strain LCB_4)",
"bird metagenome"
] | [
19817,
1,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
35,
4,
20,
7,
33,
43,
29,
38,
89
] | 9 | true | Domain | E2F/DP family, winged-helix DNA-binding domain | E2F/DP family, winged-helix DNA-binding domain | E2F_WHTH_DNA-bd_dom | 1 |
IPR003318 | 3,318 | Glycoside hydrolase, family 70, catalytic domain | Glyco_hydro70cat | Domain | 708 | false | false | O-Glycosyl hydrolases ( ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ ,... | [
"GO:0046527",
"GO:0009250"
] | [
"glucosyltransferase activity",
"glucan biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF02324"
] | [
"Glyco_hydro_70"
] | [
708
] | 1 | [
"CAZY",
"EC"
] | [
"GH70",
"2.4.1.5"
] | [
"CAZY:GH70",
"EC:2.4.1.5"
] | 2 | [
"3aib",
"3aic",
"3aie",
"3hz3",
"3klk",
"3kll",
"3tto",
"3ttq",
"4amc",
"4ayg",
"4ttu",
"4tvc",
"4tvd",
"5jbd",
"5jbe",
"5jbf",
"5lfc",
"5ngy",
"5o8l",
"6htv",
"6hvg",
"6syq",
"6szi",
"6t16",
"6t18",
"6t1p",
"7dt1",
"7p38",
"7p39",
"7zc0",
"8fg8",
"8fj9"... | 40 | [
"PUB00004870",
"PUB00005266",
"PUB00008098"
] | [
"7624375",
"8535779",
"8982063"
] | [
"Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.",
"Structures and mechanisms of glycosyl hydrolases.",
"Cloning and sequencing of a gene coding for a novel dextransucrase from Leuconostoc mesenteroides NRRL B-1299 synthesizing only alpha (1-6) and ... | [
1995,
1995,
1996
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"human gut metagenome"
] | [
707,
1
] | 2 | [] | [] | 0 | true | Domain | Glycoside hydrolase, family 70, catalytic domain | Glycoside hydrolase, family 70, catalytic domain | Glyco_hydro70cat | 2 |
IPR003321 | 3,321 | Cytochrome c552 | Cyt_c552 | Family | 3,890 | false | false | The enzyme cytochrome c nitrite reductase (c552) catalyses the six-electron reduction of nitrite to ammonia as one of the key steps in the biological nitrogen cycle, where it participates in the anaerobic energy metabolism of dissimilatory nitrate ammonification. Cytochrome c nitrite reductase from Sulfurospirillum del... | [
"GO:0042279",
"GO:0042597"
] | [
"nitrite reductase (cytochrome, ammonia-forming) activity",
"periplasmic space"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM",
"PIRSF",
"PANTHER",
"CDD"
] | [
"PF02335",
"PIRSF000243",
"PTHR30633",
"cd00548"
] | [
"Cytochrom_C552",
"Cyt_c552",
"",
"NrfA-like"
] | [
3771,
2921,
3663,
3209
] | 4 | [
"EC",
"GP",
"GP",
"METACYC"
] | [
"1.7.2.2",
"GenProp0682",
"GenProp0683",
"PWY-5674"
] | [
"EC:1.7.2.2",
"GP:GenProp0682",
"GP:GenProp0683",
"METACYC:PWY-5674"
] | 4 | [
"1fs7",
"1fs8",
"1fs9",
"1gu6",
"1oah",
"1qdb",
"2e80",
"2e81",
"2j7a",
"2ot4",
"2rdz",
"2rf7",
"2vr0",
"2zo5",
"3bnf",
"3bng",
"3bnh",
"3bnj",
"3d1i",
"3f29",
"3fo3",
"3gm6",
"3l1t",
"3lg1",
"3lgq",
"3mmo",
"3owm",
"3rkh",
"3s7w",
"3sce",
"3sxq",
"3tor"... | 54 | [
"PUB00008101"
] | [
"10440380"
] | [
"Structure of cytochrome c nitrite reductase."
] | [
1999
] | 1 | [] | [
"IPR017570"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
27,
3751,
2,
110
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Cytochrome c552 | Cytochrome c552 | Cyt_c552 | 2 |
IPR003322 | 3,322 | Beta-retroviral matrix protein | B_retro_matrix | Domain | 501 | false | false | Retroviral matrix proteins (or major core proteins) are components of envelope-associated capsids, which line the inner surface of virus envelopes and are associated with viral membranes [ ]. Matrix proteins are produced as part of Gag precursor polyproteins. During viral maturation, the Gag polyprotein is cleaved into... | [
"GO:0005198"
] | [
"structural molecule activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF02337"
] | [
"Gag_p10"
] | [
501
] | 1 | [] | [] | [] | 0 | [
"1bax",
"2f76",
"2f77",
"2mv4",
"4zv5",
"5hyb",
"5i27",
"5ldl",
"5lmy",
"8c9m"
] | 10 | [
"PUB00014063",
"PUB00016320",
"PUB00016324",
"PUB00016325",
"PUB00055853"
] | [
"9657938",
"12876457",
"15113883",
"9499052",
"18647839"
] | [
"Retroviral matrix proteins: a structural perspective.",
"The evolution, distribution and diversity of endogenous retroviruses.",
"An early stage of Mason-Pfizer monkey virus budding is regulated by the hydrophobicity of the Gag matrix domain core.",
"Nucleocapsid and matrix protein contributions to selective... | [
1998,
2003,
2004,
1998,
2008
] | 5 | [] | [] | 0 | 0 | null | [
"Bilateria",
"Retroviridae"
] | [
438,
63
] | 2 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
14,
9,
7
] | 3 | true | Domain | Beta-retroviral matrix protein | Beta-retroviral matrix protein | B_retro_matrix | 4 |
IPR003323 | 3,323 | OTU domain | OTU_dom | Domain | 44,151 | false | false | This entry also includes OTU-like domain from UDP-N-acetylglucosamine transferase subunit ALG13. This domain, however, despite containing a complete catalytic triad, do not react with Ub propargylamide and has no deubiquitinase activity [ ]. An homology region containing four conserved motifs has been identified in pro... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE"
] | [
"PF02338",
"PS50802"
] | [
"OTU",
"OTU"
] | [
34671,
42779
] | 2 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.4.19.12",
"PDOC50802",
"R-BTA-195253",
"R-BTA-5689896",
"R-CEL-5689896",
"R-DDI-5689896",
"R-DME-195253",
"R-DME-5689880",
"R-DME-5689896",
"R-DRE-5689896",
"R-HSA-168638",
"R-HSA-195253",
"R-HSA-446193",
"R-HSA-5357786",
"R-HSA-5357905",
"R-HSA-5357956",
"R-HSA-5633231",
"R-HSA... | [
"EC:3.4.19.12",
"PROSITEDOC:PDOC50802",
"REACTOME:R-BTA-195253",
"REACTOME:R-BTA-5689896",
"REACTOME:R-CEL-5689896",
"REACTOME:R-DDI-5689896",
"REACTOME:R-DME-195253",
"REACTOME:R-DME-5689880",
"REACTOME:R-DME-5689896",
"REACTOME:R-DRE-5689896",
"REACTOME:R-HSA-168638",
"REACTOME:R-HSA-195253"... | 36 | [
"1tff",
"2vfj",
"2zfy",
"3by4",
"3c0r",
"3dkb",
"3pfy",
"3phu",
"3phw",
"3phx",
"3prm",
"3prp",
"3pse",
"3pt2",
"3tmo",
"3tmp",
"3von",
"3zjd",
"3zje",
"3zjf",
"3zjg",
"3znh",
"3zrh",
"4bop",
"4boq",
"4bos",
"4bou",
"4boz",
"4ddg",
"4ddi",
"4dhi",
"4dhj"... | 88 | [
"PUB00008103",
"PUB00011704",
"PUB00020025",
"PUB00030423",
"PUB00076543",
"PUB00076953"
] | [
"10664582",
"11517925",
"9891971",
"14725770",
"23827681",
"7044372"
] | [
"A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae.",
"Evolutionary lines of cysteine peptidases.",
"Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases.",
"The structure of ... | [
2000,
2001,
1998,
2004,
2013,
1982
] | 6 | [] | [
"IPR047387",
"IPR047834",
"IPR047947",
"IPR049605",
"IPR049768",
"IPR049769",
"IPR049771",
"IPR049772"
] | 0 | 8 | 0 | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
308,
41867,
1856,
120
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
47,
13,
81,
14,
47,
39,
3,
53,
44,
2,
2,
101
] | 12 | true | Domain | OTU domain | OTU domain | OTU_dom | 2 |
IPR003325 | 3,325 | TerD domain | TerD | Domain | 28,424 | false | false | The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins [ , ]. It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium binding sites [ , ] depending on the conservation of aspartates [ ]. It has various fusions to nuclea... | [] | [] | [] | 0 | [
"PFAM",
"CDD"
] | [
"PF02342",
"cd06974"
] | [
"TerD",
"TerD_like"
] | [
26207,
27997
] | 2 | [] | [] | [] | 0 | [
"2kxt",
"2kxv",
"2qng",
"2qz7",
"3ibz"
] | 5 | [
"PUB00008105",
"PUB00008106",
"PUB00054628",
"PUB00066658"
] | [
"10203839",
"2176639",
"21112337",
"23044854"
] | [
"Bacterial tellurite resistance.",
"Cloning and characterization of cDNAs encoding a novel cyclic AMP-binding protein in Dictyostelium discoideum.",
"NMR Structure and Calcium-Binding Properties of the Tellurite Resistance Protein TerD from Klebsiella pneumoniae.",
"Ter-dependent stress response systems: nove... | [
1999,
1990,
2011,
2012
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Plasmid pMJ606",
"Viruses",
"metagenomes"
] | [
27518,
766,
1,
89,
50
] | 5 | [] | [] | 0 | true | Domain | TerD domain | TerD domain | TerD | 5 |
IPR003326 | 3,326 | TRA-1 regulated | TRA-1_regulated | Family | 218 | false | false | This family of proteins represents the protein product of the gene R03H10.4 which is located near a sequence that matches the TRA-1 binding consensus. TRA-1 is a transcription factor which controls sexual differentiation in C.elegans. R03H10.4 shows male-enriched reporter gene expression and acts as a direct target of ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02343"
] | [
"TRA-1_regulated"
] | [
218
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00055609"
] | [
"15987632"
] | [
"Genome-wide analysis of sex-enriched gene expression during C. elegans larval development."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Caenorhabditis"
] | [
218
] | 1 | [
"Caenorhabditis elegans"
] | [
43
] | 1 | true | Family | TRA-1 regulated | TRA-1 regulated | TRA-1_regulated | 3 |
IPR003327 | 3,327 | Leucine zipper, Myc | Myc-LZ | Domain | 2,021 | false | false | This family consists of the leucine zipper dimerisation domain found in both cellular c-Myc proto-oncogenes and viral v-Myc oncogenes. Dimerisation via the leucine zipper motif with other basic helix-loop-helix-leucine zipper (b/HLH/lz) proteins is required for efficient DNA binding [ ]. The Myc-Max dimer is a transact... | [
"GO:0003700",
"GO:0006355"
] | [
"DNA-binding transcription factor activity",
"regulation of DNA-templated transcription"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF02344"
] | [
"Myc-LZ"
] | [
2021
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-5689880",
"R-BTA-8866911",
"R-DRE-8866911",
"R-GGA-5689880",
"R-GGA-8866911",
"R-HSA-1362277",
"R-HSA-201556",
"R-HSA-2122947",
"R-HSA-2173796",
"R-HSA-2644606",
"R-HSA-2894862",
"R-HSA-4411364",
"R-HSA-5687128",
"R-HSA-5689880",
"R-HSA-6785807",
"R-HSA-69202",
"R-HSA-69656",
... | [
"REACTOME:R-BTA-5689880",
"REACTOME:R-BTA-8866911",
"REACTOME:R-DRE-8866911",
"REACTOME:R-GGA-5689880",
"REACTOME:R-GGA-8866911",
"REACTOME:R-HSA-1362277",
"REACTOME:R-HSA-201556",
"REACTOME:R-HSA-2122947",
"REACTOME:R-HSA-2173796",
"REACTOME:R-HSA-2644606",
"REACTOME:R-HSA-2894862",
"REACTOME... | 27 | [
"1a93",
"1nkp",
"2a93",
"5i4z",
"5i50",
"6g6j",
"6g6k",
"6g6l",
"8ots"
] | 9 | [
"PUB00008107",
"PUB00008108"
] | [
"9680483",
"10679391"
] | [
"Insights into the mechanism of heterodimerization from the 1H-NMR solution structure of the c-Myc-Max heterodimeric leucine zipper.",
"Action of Myc in vivo - proliferation and apoptosis."
] | [
1998,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Retroviridae"
] | [
2006,
15
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
4,
5,
6
] | 4 | true | Domain | Leucine zipper, Myc | Leucine zipper, Myc | Myc-LZ | 4 |
IPR003329 | 3,329 | Acylneuraminate cytidylyltransferase | Cytidylyl_trans | Family | 29,672 | false | false | Synonym(s): CMP-N-acetylneuraminic acid synthetase Acylneuraminate cytidylyltransferase ( ) (CMP-NeuAc synthetase) catalyzes the reaction of CTP and NeuAc to form CMP-NeuAc, which is the nucleotide sugar donor used by sialyltransferases [ ]. The outer membrane lipooligosaccharides of some microorganisms contain termina... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02348"
] | [
"CTP_transf_3"
] | [
29672
] | 1 | [
"EC",
"EC",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.7",
"2.7.7.38",
"GenProp0724",
"GenProp0793",
"GenProp0796",
"GenProp1325",
"GenProp1647",
"GenProp1737",
"PWY-1269",
"R-BTA-4085001",
"R-DRE-4085001",
"R-HSA-4085001",
"R-MMU-4085001",
"R-RNO-4085001"
] | [
"EC:2.7.7",
"EC:2.7.7.38",
"GP:GenProp0724",
"GP:GenProp0793",
"GP:GenProp0796",
"GP:GenProp1325",
"GP:GenProp1647",
"GP:GenProp1737",
"METACYC:PWY-1269",
"REACTOME:R-BTA-4085001",
"REACTOME:R-DRE-4085001",
"REACTOME:R-HSA-4085001",
"REACTOME:R-MMU-4085001",
"REACTOME:R-RNO-4085001"
] | 14 | [
"1eyr",
"1ezi",
"1gq9",
"1gqc",
"1h6j",
"1h7e",
"1h7f",
"1h7g",
"1h7h",
"1h7t",
"1qwj",
"1vh1",
"1vh3",
"1vic",
"2y6p",
"3duv",
"3jtj",
"3k8d",
"3k8e",
"3oam",
"3pol",
"3tqd",
"4fcu",
"4xwi",
"6ckj",
"6ckk",
"6ckl",
"6ckm",
"6ifd",
"6ifi",
"6oew",
"8ees"... | 34 | [
"PUB00008111",
"PUB00082311"
] | [
"8663048",
"23413030"
] | [
"Purification, cloning, and expression of a cytidine 5'-monophosphate N-acetylneuraminic acid synthetase from Haemophilus ducreyi.",
"The origin of 8-amino-3,8-dideoxy-D-manno-octulosonic acid (Kdo8N) in the lipopolysaccharide of Shewanella oneidensis."
] | [
1996,
2013
] | 2 | [] | [
"IPR004528",
"IPR020039"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
252,
25934,
2555,
18,
913
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
4,
3,
3,
1,
4,
4,
2,
4,
4
] | 9 | true | Family | Acylneuraminate cytidylyltransferase | Acylneuraminate cytidylyltransferase | Cytidylyl_trans | 3 |
IPR003330 | 3,330 | Major surface glycoprotein MSG | MSG | Family | 509 | false | false | The immunogenic major surface antigen (MSG) also termed glycoprotein A (gpA) is involved in the immunopathogenesis of Pneumocystis carinii. MSG from all P. carinii has conserved secondary structure, as well as function [ , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02349"
] | [
"MSG"
] | [
509
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00008112",
"PUB00008113"
] | [
"9679195",
"9712777"
] | [
"Molecular characterization of mouse Pneumocystis carinii surface glycoprotein A.",
"Characterization of major surface glycoprotein genes of human Pneumocystis carinii and high-level expression of a conserved region."
] | [
1998,
1998
] | 2 | [] | [] | 0 | 0 | null | [
"Opisthokonta",
"Sutcliffiella horikoshii"
] | [
508,
1
] | 2 | [] | [] | 0 | true | Family | Major surface glycoprotein MSG | Major surface glycoprotein MSG | MSG | 6 |
IPR003331 | 3,331 | UDP-N-acetylglucosamine 2-epimerase domain | UDP_GlcNAc_Epimerase_2_dom | Domain | 26,996 | false | false | This entry represents a domain found in the bacterial UDP-N-acetylglucosamine 2-epimerase WecB, which is involved in the enterobacterial common antigen biosynthesis [ ]. It can also be found in the N-terminal region of the mammalian bifunctional protein GNE, which has both the UDP-N-acetylglucosamine 2-epimerase and th... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02350"
] | [
"Epimerase_2"
] | [
26996
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-4085001",
"R-HSA-4085011",
"R-MMU-4085001",
"R-RNO-4085001"
] | [
"REACTOME:R-HSA-4085001",
"REACTOME:R-HSA-4085011",
"REACTOME:R-MMU-4085001",
"REACTOME:R-RNO-4085001"
] | 4 | [
"1f6d",
"1o6c",
"1v4v",
"1vgv",
"3beo",
"3dzc",
"3ot5",
"4fkz",
"4hwg",
"4neq",
"4nes",
"4zht",
"5dld",
"5enz",
"5xvs",
"5zlr",
"5zlt",
"6vlb",
"6vlc",
"7vyy",
"7vz6",
"7vza",
"7ya2",
"8ahe",
"8ahf",
"8sxv",
"8sxw",
"8sxy",
"8sy0",
"8sy9",
"8sya",
"8syb"... | 36 | [
"PUB00042837",
"PUB00076993",
"PUB00076994"
] | [
"2166030",
"11929971",
"18275154"
] | [
"Biosynthesis of enterobacterial common antigen in Escherichia coli. Biochemical characterization of Tn10 insertion mutants defective in enterobacterial common antigen synthesis.",
"Sialylation is essential for early development in mice.",
"Biosynthesis of CMP-N,N'-diacetyllegionaminic acid from UDP-N,N'-diacet... | [
1990,
2002,
2008
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
851,
23661,
1801,
20,
663
] | 5 | [
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
1,
5,
8,
7
] | 5 | true | Domain | UDP-N-acetylglucosamine 2-epimerase domain | UDP-N-acetylglucosamine 2-epimerase domain | UDP_GlcNAc_Epimerase_2_dom | 4 |
IPR003332 | 3,332 | Decorin-binding protein | Decorin-bd | Family | 158 | false | false | Decorin is a proteoglycan that decorates collagen fibres. Borrelia burgdorferi causes lyme disease, a tick-borne infection that can develop into a chronic, multisystemic disorder. Decorin may mediate the adherence of B. burgdorferi to collagen fibres in skin and other tissues [ ]. B. burgdorferi decorin binding protein... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02352"
] | [
"Decorin_bind"
] | [
158
] | 1 | [] | [] | [] | 0 | [
"2lqu",
"2mtc",
"2mtd",
"2mvg",
"4onr",
"9bqw"
] | 6 | [
"PUB00008117",
"PUB00008118",
"PUB00097461",
"PUB00097462"
] | [
"7642279",
"9784533",
"24842928",
"25695518"
] | [
"Adherence of Borrelia burgdorferi to the proteoglycan decorin.",
"Molecular analysis of sequence heterogeneity among genes encoding decorin binding proteins A and B of Borrelia burgdorferi sensu lato.",
"Identification of lysine residues in the Borrelia burgdorferi DbpA adhesin required for murine infection.",... | [
1995,
1998,
2014,
2015
] | 4 | [] | [] | 0 | 0 | null | [
"Borreliaceae"
] | [
158
] | 1 | [] | [] | 0 | true | Family | Decorin-binding protein | Decorin-binding protein | Decorin-bd | 2 |
IPR003333 | 3,333 | Cyclopropane mycolic acid synthase | CMAS | Family | 25,954 | false | false | This entry represents cyclopropane mycolic acid synthases (CMAS) and related enzymes, including CmaA1, CmaA2 (cyclopropane mycolic acid synthase A1 and A2), MmaA1-4 (methoxymycolic acid synthase A1-4) and tuberculostearic acid methyltransferase UfaA1. All are thought to be S-adenosyl-L-methionine (SAM) utilising methyl... | [
"GO:0008610"
] | [
"lipid biosynthetic process"
] | [
"biological_process"
] | 1 | [
"PIRSF"
] | [
"PIRSF003085"
] | [
"CMAS"
] | [
25954
] | 1 | [
"EC"
] | [
"2.1.1"
] | [
"EC:2.1.1"
] | 1 | [
"1kp9",
"1kpg",
"1kph",
"1kpi",
"1l1e",
"1tpy",
"2fk7",
"2fk8",
"3ha3",
"3ha5",
"3ha7",
"3hem",
"5z9o",
"6bqc",
"7l9u",
"7lxi",
"7mcj",
"7q2b",
"7q2c",
"7q2d",
"7q2e",
"7q2f",
"7q2g",
"7q2h",
"7qos",
"8raq",
"8rbd",
"8rbe",
"8rbl",
"8t1a"
] | 30 | [
"PUB00008119",
"PUB00022044",
"PUB00077550"
] | [
"7592990",
"11756461",
"23435098"
] | [
"The biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis. Identification and functional analysis of CMAS-2.",
"Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis.",
"Biochemical characterization of an S-adenosyl-l-methionine-dependent methyltransfer... | [
1995,
2002,
2013
] | 3 | [] | [
"IPR047672",
"IPR048027"
] | 0 | 2 | 0 | [
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified Candidatus Thermoprofundales",
"unclassified sequences"
] | [
23712,
1980,
13,
6,
243
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
5,
2,
1,
2,
2
] | 5 | true | Family | Cyclopropane mycolic acid synthase | Cyclopropane mycolic acid synthase | CMAS | 1 |
IPR003334 | 3,334 | GPCR, family 2, latrophilin, C-terminal | GPCR_2_latrophilin_rcpt_C | Domain | 9,737 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0004930",
"GO:0007186",
"GO:0016020"
] | [
"G protein-coupled receptor activity",
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM"
] | [
"PF02354"
] | [
"Latrophilin"
] | [
9737
] | 1 | [] | [] | [] | 0 | [
"7wy5",
"7wy8",
"7wyb",
"7x10"
] | 4 | [
"PUB00001208",
"PUB00004310",
"PUB00004961",
"PUB00005147",
"PUB00005148",
"PUB00007627",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816",
"PUB00095314"
] | [
"1646711",
"1314625",
"8170923",
"1658940",
"1658941",
"10025961",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293",
"26235031"
] | [
"Molecular cloning and expression of a cDNA encoding the secretin receptor.",
"Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide.",
"Fingerprinting G-protein-coupled receptors.",
"Expression cloning of an adenylate cyclase-coupled calcitonin receptor.",
... | [
1991,
1992,
1994,
1991,
1991,
1999,
2003,
1994,
2005,
2009,
2006,
2013,
2015
] | 13 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
9737
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
134,
35,
39,
48
] | 4 | true | Domain | GPCR, family 2, latrophilin, C-terminal | GPCR, family 2, latrophilin, C-terminal | GPCR_2_latrophilin_rcpt_C | 3 |
IPR003337 | 3,337 | Trehalose-phosphatase | Trehalose_PPase | Family | 29,681 | false | false | Trehalose-phosphatases catalyse the de-phosphorylation of trehalose-6-phosphate to trehalose and orthophosphate. Trehalose is a common disaccharide of bacteria, fungi and invertebrates that appears to play a major role in desiccation tolerance. A pathway for trehalose biosynthesis may also exist in plants [ ]. The treh... | [
"GO:0005992"
] | [
"trehalose biosynthetic process"
] | [
"biological_process"
] | 1 | [
"PFAM",
"NCBIFAM"
] | [
"PF02358",
"TIGR00685"
] | [
"Trehalose_PPase",
"T6PP"
] | [
29674,
25061
] | 2 | [
"EC",
"GP",
"METACYC",
"METACYC",
"METACYC",
"REACTOME"
] | [
"3.1.3.12",
"GenProp0265",
"PWY-7900",
"PWY-881",
"PWYG-321",
"R-MTU-868688"
] | [
"EC:3.1.3.12",
"GP:GenProp0265",
"METACYC:PWY-7900",
"METACYC:PWY-881",
"METACYC:PWYG-321",
"REACTOME:R-MTU-868688"
] | 6 | [
"1u02",
"5dx9",
"5dxi",
"5dxl",
"5dxn",
"5dxo",
"5gvx",
"5hus",
"6qj6",
"6rcz",
"6upb",
"6upc",
"6upd",
"6upe"
] | 14 | [
"PUB00001848",
"PUB00008121",
"PUB00152087"
] | [
"8045430",
"9681009",
"27469628"
] | [
"Analysis of the otsBA operon for osmoregulatory trehalose synthesis in Escherichia coli and homology of the OtsA and OtsB proteins to the yeast trehalose-6-phosphate synthase/phosphatase complex.",
"Trehalose-6-phosphate phosphatases from Arabidopsis thaliana: identification by functional complementation of the ... | [
1994,
1998,
2016
] | 3 | [
"IPR006379"
] | [
"IPR044651"
] | 1 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
247,
11235,
18088,
111
] | 4 | [
"Arabidopsis thaliana",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / A... | [
98,
25,
1,
2,
68,
3,
4,
186
] | 8 | true | Family | Trehalose-phosphatase | Trehalose-phosphatase | Trehalose_PPase | 5 |
IPR003338 | 3,338 | CDC48, N-terminal subdomain | CDC4_N-term_subdom | Domain | 15,944 | false | false | This entry represents the amino-terminal subdomain. The CDC48 N-terminal domain is a protein domain found in AAA ATPases including cell division protein 48 (CDC48), VCP-like ATPase (VAT) and N-ethylmaleimide sensitive fusion protein. It is a substrate recognition domain which binds polypeptides, prevents protein aggreg... | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF02359",
"SM01073"
] | [
"CDC48_N",
"CDC48_N"
] | [
13478,
15813
] | 2 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.6.4.6",
"R-CEL-110320",
"R-CEL-204005",
"R-CEL-3371511",
"R-CEL-382556",
"R-CEL-532668",
"R-CEL-5358346",
"R-CEL-5689877",
"R-CEL-6798695",
"R-CEL-6807878",
"R-CEL-6811434",
"R-CEL-6811438",
"R-CEL-6811440",
"R-CEL-8876725",
"R-CEL-8951664",
"R-CEL-9013407",
"R-CEL-9755511",
"R-... | [
"EC:3.6.4.6",
"REACTOME:R-CEL-110320",
"REACTOME:R-CEL-204005",
"REACTOME:R-CEL-3371511",
"REACTOME:R-CEL-382556",
"REACTOME:R-CEL-532668",
"REACTOME:R-CEL-5358346",
"REACTOME:R-CEL-5689877",
"REACTOME:R-CEL-6798695",
"REACTOME:R-CEL-6807878",
"REACTOME:R-CEL-6811434",
"REACTOME:R-CEL-6811438"... | 135 | [
"1cr5",
"1cz4",
"1cz5",
"1e32",
"1qcs",
"1qdn",
"1r7r",
"1s3s",
"2pjh",
"3cf1",
"3cf2",
"3cf3",
"3hu1",
"3hu2",
"3hu3",
"3j94",
"3j95",
"3j96",
"3j97",
"3j98",
"3j99",
"3qc8",
"3qq7",
"3qq8",
"3qwz",
"3tiw",
"4kdi",
"4kdl",
"4kln",
"4ko8",
"4kod",
"4rv0"... | 240 | [
"PUB00007420"
] | [
"10531028"
] | [
"The solution structure of VAT-N reveals a 'missing link' in the evolution of complex enzymes from a simple betaalphabetabeta element."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
2239,
1865,
11748,
3,
89
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
16,
4,
8,
7,
30,
4,
1,
7,
9,
2,
3,
38
] | 12 | true | Domain | CDC48, N-terminal subdomain | CDC48, N-terminal subdomain | CDC4_N-term_subdom | 1 |
IPR003339 | 3,339 | ABC/ECF transporter, transmembrane component | ABC/ECF_trnsptr_transmembrane | Family | 35,290 | false | false | ECF (energy-coupling factor) transporters are a subgroup of ABC (ATP-binding cassette) transporters involved in the uptake of vitamins and micronutrients in prokaryotes [ ]. ECF transporters are protein complexes consisting of a conserved module (two peripheral ATPases, known as the A and A' components, and the integra... | [] | [] | [] | 0 | [
"PFAM",
"CDD"
] | [
"PF02361",
"cd16914"
] | [
"CbiQ",
"EcfT"
] | [
33335,
34158
] | 2 | [
"GP"
] | [
"GenProp1094"
] | [
"GP:GenProp1094"
] | 1 | [
"4huq",
"4hzu",
"4rfs",
"5d3m",
"5jsz",
"5x3x",
"5x41",
"6fnp",
"6zg3",
"7nnt",
"7nnu",
"8bmp",
"8bmq",
"8bmr",
"8bms",
"9kym"
] | 16 | [
"PUB00035607",
"PUB00056838",
"PUB00067061",
"PUB00070813",
"PUB00110644",
"PUB00110645"
] | [
"16352848",
"21135102",
"23584587",
"22574898",
"24362466",
"24156876"
] | [
"Comparative and functional genomic analysis of prokaryotic nickel and cobalt uptake transporters: evidence for a novel group of ATP-binding cassette transporters.",
"Quaternary structure and functional unit of energy coupling factor (ECF)-type transporters.",
"Structure of a bacterial energy-coupling factor tr... | [
2006,
2011,
2013,
2012,
2014,
2013
] | 6 | [] | [
"IPR012809",
"IPR024919"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Myoviridae sp. ctWXg38",
"unclassified sequences"
] | [
1727,
32459,
624,
1,
479
] | 5 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
3,
2,
1
] | 3 | true | Family | ABC/ECF transporter, transmembrane component | ABC/ECF transporter, transmembrane component | ABC/ECF_trnsptr_transmembrane | 8 |
IPR003340 | 3,340 | B3 DNA binding domain | B3_DNA-bd | Domain | 56,152 | false | false | Two DNA binding proteins, RAV1 and RAV2 from Arabidopsis thaliana contain two distinct amino acid sequence domains found only in higher plant species. The N-terminal regions of RAV1 and RAV2 are homologous to the AP2 DNA-binding domain (see ) present in a family of transcription factors, while the C-terminal region exh... | [
"GO:0003677"
] | [
"DNA binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE",
"SMART",
"CDD"
] | [
"PF02362",
"PS50863",
"SM01019",
"cd10017"
] | [
"B3",
"B3",
"B3",
"B3_DNA"
] | [
50203,
50234,
47629,
53382
] | 4 | [
"PROSITEDOC"
] | [
"PDOC50863"
] | [
"PROSITEDOC:PDOC50863"
] | 1 | [
"1wid",
"1yel",
"4i1k",
"4ldu",
"4ldv",
"4ldw",
"4ldx",
"4ldy",
"5os9",
"5yzy",
"5yzz",
"5z00",
"6fas",
"6j9a",
"6j9b",
"6j9c",
"6sdg",
"6ycq",
"7et6",
"8oj1",
"8oj2"
] | 21 | [
"PUB00008122",
"PUB00018332"
] | [
"9862967",
"9165754"
] | [
"RAV1, a novel DNA-binding protein, binds to bipartite recognition sequence through two distinct DNA-binding domains uniquely found in higher plants.",
"The conserved B3 domain of VIVIPAROUS1 has a cooperative DNA binding activity."
] | [
1999,
1997
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Paenibacillus nanensis"
] | [
56151,
1
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
596,
204,
552
] | 3 | true | Domain | B3 DNA binding domain | B3 DNA binding domain | B3_DNA-bd | 6 |
IPR003341 | 3,341 | Cysteine rich repeat, tripleX | Cys_rich_tripleX | Repeat | 709 | false | false | This signature describes a cysteine repeat C-X3-C-X3-C the function of which is unknown as is the function of the proteins in which they occur. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02363"
] | [
"C_tripleX"
] | [
709
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Photobacterium damselae"
] | [
708,
1
] | 2 | [
"Caenorhabditis elegans"
] | [
34
] | 1 | true | Repeat | Cysteine rich repeat, tripleX | Cysteine rich repeat, tripleX | Cys_rich_tripleX | 7 |
IPR003342 | 3,342 | ArnT-like, N-terminal domain | ArnT-like_N | Domain | 22,439 | false | false | This entry represents the N-terminal domain found in glycosyltransferase family 39 members, including Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase (ArnT), Protein O-mannosyl-transferase 2 (pomt2) and Dolichyl-phosphate-mannose--protein mannosyltransferase proteins. This domain contain... | [
"GO:0000030",
"GO:0006493",
"GO:0016020"
] | [
"mannosyltransferase activity",
"protein O-linked glycosylation",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM"
] | [
"PF02366"
] | [
"PMT"
] | [
22439
] | 1 | [
"CAZY",
"EC",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"... | [
"GT39",
"2.4.2.43",
"GenProp1455",
"R-DME-8932504",
"R-DME-8932505",
"R-DME-8932506",
"R-DME-9768727",
"R-DRE-8932504",
"R-DRE-8932505",
"R-DRE-8932506",
"R-DRE-9768727",
"R-HSA-5083629",
"R-HSA-5083633",
"R-HSA-8932504",
"R-HSA-8932505",
"R-HSA-8932506",
"R-HSA-9768727",
"R-MMU-89... | [
"CAZY:GT39",
"EC:2.4.2.43",
"GP:GenProp1455",
"REACTOME:R-DME-8932504",
"REACTOME:R-DME-8932505",
"REACTOME:R-DME-8932506",
"REACTOME:R-DME-9768727",
"REACTOME:R-DRE-8932504",
"REACTOME:R-DRE-8932505",
"REACTOME:R-DRE-8932506",
"REACTOME:R-DRE-9768727",
"REACTOME:R-HSA-5083629",
"REACTOME:R-... | 25 | [
"6p25",
"6p2r",
"9e61",
"9e6i",
"9e6v"
] | 5 | [
"PUB00008123",
"PUB00009409"
] | [
"8918452",
"9334165"
] | [
"The PMT gene family: protein O-glycosylation in Saccharomyces cerevisiae is vital.",
"A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities."
] | [
1996,
1997
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
74,
12085,
10075,
205
] | 4 | [
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe... | [
4,
3,
1,
43,
5,
4,
6,
7,
3
] | 9 | true | Domain | ArnT-like, N-terminal domain | ArnT-like, N-terminal domain | ArnT-like_N | 4 |
IPR003343 | 3,343 | Bacterial Ig-like domain, group 2 | Big_2 | Domain | 24,178 | false | false | The Ig-like fold is part of proteins with important roles in different physiological processes [ ]. This entry represents the bacterial Ig-like domain (Big2). This domain is mainly found in a variety of bacterial and phage surface proteins such as intimins, but has also been found in several eukaryote proteins [ ]. Int... | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF02368",
"SM00635"
] | [
"Big_2",
"BID_2"
] | [
21132,
21208
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-1169408",
"R-HSA-159227",
"R-HSA-159230",
"R-HSA-159231",
"R-HSA-159236",
"R-HSA-165054",
"R-HSA-168271",
"R-HSA-168276",
"R-HSA-168325",
"R-HSA-168333",
"R-HSA-170822",
"R-HSA-180746",
"R-HSA-180910",
"R-HSA-191859",
"R-HSA-3108214",
"R-HSA-3232142",
"R-HSA-3301854",
"R-HSA... | [
"REACTOME:R-HSA-1169408",
"REACTOME:R-HSA-159227",
"REACTOME:R-HSA-159230",
"REACTOME:R-HSA-159231",
"REACTOME:R-HSA-159236",
"REACTOME:R-HSA-165054",
"REACTOME:R-HSA-168271",
"REACTOME:R-HSA-168276",
"REACTOME:R-HSA-168325",
"REACTOME:R-HSA-168333",
"REACTOME:R-HSA-170822",
"REACTOME:R-HSA-18... | 58 | [
"1e5u",
"1f00",
"1f02",
"2l04",
"2mh4",
"2mog",
"2mqg",
"2n7s",
"2zqk",
"2zwk",
"3ncw",
"3ncx",
"4aq1",
"4hu8",
"4uic",
"4uid",
"4uj6",
"4uj7",
"4uj8",
"5ftx",
"5fty",
"5ngj",
"6hhu",
"6n1a",
"6n1b",
"6p3e",
"6qvk",
"6qx4",
"6qyd",
"6qz0",
"7qg9",
"7quz"... | 80 | [
"PUB00006623",
"PUB00014503",
"PUB00094496",
"PUB00098245",
"PUB00099869",
"PUB00099871"
] | [
"10890451",
"10201396",
"23911548",
"14517331",
"20826161",
"16631788"
] | [
"Crystal structure of enteropathogenic Escherichia coli intimin-receptor complex.",
"Structure of the cell-adhesion fragment of intimin from enteropathogenic Escherichia coli.",
"Chaperone-protein interactions that mediate assembly of the bacteriophage lambda tail to the correct length.",
"Nuclear pore protei... | [
2000,
1999,
2014,
2003,
2010,
2006
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
140,
20142,
2642,
1020,
234
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Zea mays"
] | [
4,
1,
1,
4,
5,
5,
7
] | 7 | true | Domain | Bacterial Ig-like domain, group 2 | Bacterial Ig-like domain, group 2 | Big_2 | 1 |
IPR003344 | 3,344 | Big-1 (bacterial Ig-like domain 1) domain | Big_1_dom | Domain | 5,798 | false | false | The bacterial immunoglobulin-like (Ig) domain 1 or Big-1 domain is a domain of ~95 amino acids present in bacterial adhesion molecules of the intimin/invasin family, involved in pathogenicity, and YeeJ, a inverse autotransporter adhesin. The domain is named after the 3D structure of the domain in enteropathogenic Esche... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF02369",
"PS51127",
"SM00634"
] | [
"Big_1",
"BIG1",
"BID_1"
] | [
4123,
4853,
4563
] | 3 | [
"PROSITEDOC"
] | [
"PDOC51127"
] | [
"PROSITEDOC:PDOC51127"
] | 1 | [
"1cwv",
"1f00",
"1f02",
"4e9l",
"5ldy",
"5n40",
"6tpl",
"6tqd",
"6xgr",
"8qox",
"8vhx",
"8vja",
"8vjh"
] | 13 | [
"PUB00006623",
"PUB00014503",
"PUB00018560"
] | [
"10890451",
"10201396",
"10514372"
] | [
"Crystal structure of enteropathogenic Escherichia coli intimin-receptor complex.",
"Structure of the cell-adhesion fragment of intimin from enteropathogenic Escherichia coli.",
"Crystal structure of invasin: a bacterial integrin-binding protein."
] | [
2000,
1999,
1999
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
356,
5285,
28,
50,
79
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Big-1 (bacterial Ig-like domain 1) domain | Big-1 (bacterial Ig-like domain 1) domain | Big_1_dom | 6 |
IPR003345 | 3,345 | M protein repeat | M_repeat | Repeat | 559 | false | false | This short repeat is found in multiple copies in bacterial M proteins. The M proteins bind to IgA and are closely associated with virulence. The M protein has been postulated to be a major group A streptococcal (GAS) virulence factor because of its contribution to the bacterial resistance to opsonophagocytosis [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02370"
] | [
"M"
] | [
559
] | 1 | [] | [] | [] | 0 | [
"2kk9",
"8skv"
] | 2 | [
"PUB00008124"
] | [
"8830235"
] | [
"M-related protein (Mrp) contributes to group A streptococcal resistance to phagocytosis by human granulocytes."
] | [
1996
] | 1 | [] | [] | 0 | 0 | null | [
"Dicentrarchus labrax",
"Streptococcus"
] | [
3,
556
] | 2 | [] | [] | 0 | true | Repeat | M protein repeat | M protein repeat | M_repeat | 5 |
IPR003346 | 3,346 | Transposase IS116/IS110/IS902, C-terminal | Transposase_20 | Domain | 42,332 | false | false | Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This entry represents the C-terminal domain of region of the pilin gene inverting protein (PIVML) and transposases IS116, IS110 and IS902 [ , ]. | [
"GO:0003677",
"GO:0004803",
"GO:0006313"
] | [
"DNA binding",
"transposase activity",
"DNA transposition"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM"
] | [
"PF02371"
] | [
"Transposase_20"
] | [
42332
] | 1 | [] | [] | [] | 0 | [
"8wt6",
"8wt7",
"8wt8",
"8wt9",
"9mty"
] | 5 | [
"PUB00034637",
"PUB00034638"
] | [
"1348267",
"10217489"
] | [
"IS902, an insertion element of the chronic-enteritis-causing Mycobacterium avium subsp. silvaticum.",
"Characterization of IS2112, a new insertion sequence from Rhodococcus, and its relationship with mobile elements belonging to the IS110 family."
] | [
1992,
1999
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"plasmids",
"unclassified sequences"
] | [
692,
40706,
126,
21,
4,
783
] | 6 | [] | [] | 0 | true | Domain | Transposase IS116/IS110/IS902, C-terminal | Transposase IS116/IS110/IS902, C-terminal | Transposase_20 | 6 |
IPR003347 | 3,347 | JmjC domain | JmjC_dom | Domain | 105,389 | false | false | The JmjN and JmjC domains are two non-adjacent domains which have been identified in the jumonji family of transcription factors. Although it was originally suggested that the JmjN and JmjC domains always co-occur and might form a single functional unit within the folded protein, the JmjC domain was later found without... | [] | [] | [] | 0 | [
"PFAM",
"PFAM",
"PROFILE",
"SMART"
] | [
"PF02373",
"PF08007",
"PS51184",
"SM00558"
] | [
"JmjC",
"JmjC_2",
"JMJC",
"JmjC"
] | [
54256,
14248,
103719,
88371
] | 4 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"1.14.11",
"PDOC51183",
"R-BTA-9629569",
"R-CEL-2299718",
"R-CEL-2559580",
"R-CEL-3214842",
"R-CEL-9629569",
"R-DDI-9629569",
"R-DME-212300",
"R-DME-3214842",
"R-DME-5625886",
"R-DME-5693565",
"R-DME-8866911",
"R-DME-9018519",
"R-DME-9629569",
"R-DME-983231",
"R-DRE-1234174",
"R-DR... | [
"EC:1.14.11",
"PROSITEDOC:PDOC51183",
"REACTOME:R-BTA-9629569",
"REACTOME:R-CEL-2299718",
"REACTOME:R-CEL-2559580",
"REACTOME:R-CEL-3214842",
"REACTOME:R-CEL-9629569",
"REACTOME:R-DDI-9629569",
"REACTOME:R-DME-212300",
"REACTOME:R-DME-3214842",
"REACTOME:R-DME-5625886",
"REACTOME:R-DME-5693565... | 65 | [
"1h2k",
"1h2l",
"1h2m",
"1h2n",
"1iz3",
"1mze",
"1mzf",
"1vrb",
"1yci",
"2cgn",
"2cgo",
"2gp3",
"2gp5",
"2ilm",
"2oq6",
"2oq7",
"2os2",
"2ot7",
"2ox0",
"2p5b",
"2pxj",
"2q8c",
"2q8d",
"2q8e",
"2vd7",
"2w0x",
"2w2i",
"2wa3",
"2wa4",
"2wwj",
"2wwu",
"2xdv"... | 708 | [
"PUB00007419",
"PUB00008126",
"PUB00021054",
"PUB00021723",
"PUB00033727",
"PUB00057442",
"PUB00070012",
"PUB00099121"
] | [
"11165500",
"10838566",
"15809658",
"12446723",
"16362057",
"20739293",
"16983801",
"24814345"
] | [
"JmjC: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2beta.",
"Evidence of domain swapping within the jumonji family of transcription factors.",
"Methylation: lost in hydroxylation?",
"Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modif... | [
2001,
2000,
2005,
2003,
2006,
2010,
2006,
2014
] | 8 | [] | [
"IPR041667"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
16106,
89088,
42,
153
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
118,
21,
176,
27,
1,
186,
88,
10,
61,
143,
5,
7,
243
] | 13 | true | Domain | JmjC domain | JmjC domain | JmjC_dom | 6 |
IPR003349 | 3,349 | JmjN domain | JmjN | Domain | 23,031 | false | false | This entry represents the JmjN domain. The JmjN and JmjC domains are two non-adjacent domains which have been identified in the jumonji family of transcription factors. Although it was originally suggested that the JmjN and JmjC domains always co-occur and might form a single functional unit within the folded protein, ... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF02375",
"PS51183",
"SM00545"
] | [
"JmjN",
"JMJN",
"JmjN"
] | [
22458,
22915,
22673
] | 3 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"1.14.11",
"PDOC51183",
"R-CEL-3214842",
"R-DME-212300",
"R-DME-5625886",
"R-DME-5693565",
"R-DME-8866911",
"R-DME-9018519",
"R-DRE-212300",
"R-DRE-8866911",
"R-GGA-8866911",
"R-HSA-212300",
"R-HSA-3214842",
"R-HSA-5625886",
"R-HSA-5693565",
"R-HSA-8866911",
"R-HSA-9018519",
"R-HSA... | [
"EC:1.14.11",
"PROSITEDOC:PDOC51183",
"REACTOME:R-CEL-3214842",
"REACTOME:R-DME-212300",
"REACTOME:R-DME-5625886",
"REACTOME:R-DME-5693565",
"REACTOME:R-DME-8866911",
"REACTOME:R-DME-9018519",
"REACTOME:R-DRE-212300",
"REACTOME:R-DRE-8866911",
"REACTOME:R-GGA-8866911",
"REACTOME:R-HSA-212300",... | 30 | [
"2gp3",
"2gp5",
"2oq6",
"2oq7",
"2os2",
"2ot7",
"2ox0",
"2p5b",
"2pxj",
"2q8c",
"2q8d",
"2q8e",
"2vd7",
"2w2i",
"2wwj",
"2xml",
"2ybk",
"2ybp",
"2ybs",
"3dxt",
"3dxu",
"3njy",
"3opt",
"3opw",
"3pdq",
"3rvh",
"3u4s",
"4ai9",
"4bis",
"4d6q",
"4d6r",
"4d6s"... | 476 | [
"PUB00007419",
"PUB00008126",
"PUB00021723",
"PUB00033727"
] | [
"11165500",
"10838566",
"12446723",
"16362057"
] | [
"JmjC: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2beta.",
"Evidence of domain swapping within the jumonji family of transcription factors.",
"Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha.",
"Histone deme... | [
2001,
2000,
2003,
2006
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanolobus vulcani",
"bird metagenome"
] | [
3,
23026,
1,
1
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
43,
3,
25,
11,
52,
30,
2,
17,
38,
4,
3,
124
] | 12 | true | Domain | JmjN domain | JmjN domain | JmjN | 7 |
IPR003350 | 3,350 | CUT domain | CUT_dom | Domain | 10,526 | false | false | The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein. | [
"GO:0003677"
] | [
"DNA binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF02376",
"PS51042",
"SM01109"
] | [
"CUT",
"CUT",
"CUT"
] | [
10422,
10478,
10308
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC51042",
"R-HSA-111465",
"R-HSA-1839117",
"R-HSA-210744",
"R-HSA-210747",
"R-HSA-4551638",
"R-HSA-5655302",
"R-HSA-8940973",
"R-HSA-9925561",
"R-HSA-9925563",
"R-HSA-9937080",
"R-MMU-111465",
"R-MMU-4551638"
] | [
"PROSITEDOC:PDOC51042",
"REACTOME:R-HSA-111465",
"REACTOME:R-HSA-1839117",
"REACTOME:R-HSA-210744",
"REACTOME:R-HSA-210747",
"REACTOME:R-HSA-4551638",
"REACTOME:R-HSA-5655302",
"REACTOME:R-HSA-8940973",
"REACTOME:R-HSA-9925561",
"REACTOME:R-HSA-9925563",
"REACTOME:R-HSA-9937080",
"REACTOME:R-M... | 13 | [
"1s7e",
"1wh6",
"1wh8",
"1wiz",
"1x2l",
"1yse",
"2csf",
"2d5v",
"2o49",
"2o4a",
"6lff",
"8t0f",
"8t11"
] | 13 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobrevibacter arboriphilus",
"marine sediment metagenome"
] | [
26,
10496,
3,
1
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
20,
69,
7,
16,
20,
28
] | 6 | true | Domain | CUT domain | CUT domain | CUT_dom | 9 |
IPR003351 | 3,351 | Dishevelled protein domain | Dishevelled_protein_dom | Domain | 4,861 | false | false | This domain is specific to the signalling protein dishevelled. Dishevelled (Dsh/Dvl) is a highly conserved protein family that plays an important role in mediating Wnt signaling. Wnt signal transduction pathways control a variety of developmental and homeostatic events. Dishevelled is involved in both the canonical and... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02377"
] | [
"Dishevelled"
] | [
4861
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-201688",
"R-DME-209440",
"R-DME-350368",
"R-DME-350369",
"R-DME-350376",
"R-DME-350411",
"R-DME-350480",
"R-DME-4086400",
"R-DME-450728",
"R-DME-4608870",
"R-DME-4641258",
"R-DME-4641262",
"R-DME-5099900",
"R-DME-5663220",
"R-HSA-201681",
"R-HSA-201688",
"R-HSA-2028269",
"R-... | [
"REACTOME:R-DME-201688",
"REACTOME:R-DME-209440",
"REACTOME:R-DME-350368",
"REACTOME:R-DME-350369",
"REACTOME:R-DME-350376",
"REACTOME:R-DME-350411",
"REACTOME:R-DME-350480",
"REACTOME:R-DME-4086400",
"REACTOME:R-DME-450728",
"REACTOME:R-DME-4608870",
"REACTOME:R-DME-4641258",
"REACTOME:R-DME-... | 49 | [
"8wm9",
"8wma"
] | 2 | [
"PUB00060614"
] | [
"20006983"
] | [
"Dishevelled: The hub of Wnt signaling."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
4861
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
26,
1,
16,
8,
8
] | 6 | true | Domain | Dishevelled protein domain | Dishevelled protein domain | Dishevelled_protein_dom | 8 |
IPR003352 | 3,352 | Phosphotransferase system, EIIC | PTS_EIIC | Domain | 86,243 | false | false | The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The PTS catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. The gen... | [
"GO:0008982",
"GO:0009401",
"GO:0016020"
] | [
"protein-N(PI)-phosphohistidine-sugar phosphotransferase activity",
"phosphoenolpyruvate-dependent sugar phosphotransferase system",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PFAM"
] | [
"PF02378",
"PF13303"
] | [
"PTS_EIIC",
"PTS_EIIC_2"
] | [
81364,
4879
] | 2 | [
"EC",
"GP"
] | [
"2.7.1",
"GenProp0119"
] | [
"EC:2.7.1",
"GP:GenProp0119"
] | 2 | [
"3qnq",
"5iws",
"6bvg",
"8qsr",
"8qst",
"9hnp"
] | 6 | [
"PUB00002162",
"PUB00060540"
] | [
"1537788",
"22493022"
] | [
"Proposed uniform nomenclature for the proteins and protein domains of the bacterial phosphoenolpyruvate: sugar phosphotransferase system.",
"Fructose degradation in the haloarchaeon Haloferax volcanii involves a bacterial type phosphoenolpyruvate-dependent phosphotransferase system, fructose-1-phosphate kinase, ... | [
1992,
2012
] | 2 | [] | [
"IPR004501",
"IPR013013",
"IPR013014"
] | 0 | 3 | 0 | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"unclassified sequences"
] | [
85867,
73,
109,
194
] | 4 | [
"Escherichia coli (strain K12)"
] | [
15
] | 1 | true | Domain | Phosphotransferase system, EIIC | Phosphotransferase system, EIIC | PTS_EIIC | 1 |
IPR003353 | 3,353 | Phosphotransferase system, fructose-specific IIB subunit | PTS_IIB_fruc | Domain | 18,156 | false | false | The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The PTS catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. The gen... | [
"GO:0022877",
"GO:0009401"
] | [
"protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity",
"phosphoenolpyruvate-dependent sugar phosphotransferase system"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM",
"CDD"
] | [
"TIGR00829",
"cd05569"
] | [
"FRU",
"PTS_IIB_fructose"
] | [
17694,
18137
] | 2 | [
"EC",
"GP",
"GP"
] | [
"2.7.1.202",
"GenProp0119",
"GenProp0693"
] | [
"EC:2.7.1.202",
"GP:GenProp0119",
"GP:GenProp0693"
] | 3 | [
"2kyr",
"2m1z",
"2r48",
"2r4q",
"4tn5",
"5dle"
] | 6 | [
"PUB00002162",
"PUB00070132"
] | [
"1537788",
"16339738"
] | [
"Proposed uniform nomenclature for the proteins and protein domains of the bacterial phosphoenolpyruvate: sugar phosphotransferase system.",
"Comparative genomic analyses of the bacterial phosphotransferase system."
] | [
1992,
2005
] | 2 | [
"IPR013011"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"metagenomes"
] | [
17985,
14,
115,
42
] | 4 | [
"Escherichia coli (strain K12)"
] | [
6
] | 1 | true | Domain | Phosphotransferase system, fructose-specific IIB subunit | Phosphotransferase system, fructose-specific IIB subunit | PTS_IIB_fruc | 9 |
IPR003354 | 3,354 | Small/middle T-antigen | Papo_T_antigen | Domain | 469 | false | false | This domain represents a conserved region in papovavirus small and middle T-antigens. It is found as the N-terminal domain in the small T-antigen, and is centrally located in the middle T-antigen [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02380"
] | [
"Papo_T_antigen"
] | [
469
] | 1 | [] | [] | [] | 0 | [
"2pf4",
"2pkg"
] | 2 | [
"PUB00019991"
] | [
"9557685"
] | [
"Natural isolates of simian virus 40 from immunocompromised monkeys display extensive genetic heterogeneity: new implications for polyomavirus disease."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Mus musculus",
"Polyomaviridae"
] | [
2,
467
] | 2 | [
"Mus musculus"
] | [
2
] | 1 | true | Domain | Small/middle T-antigen | Small/middle T-antigen | Papo_T_antigen | 4 |
IPR003356 | 3,356 | DNA methylase, adenine-specific | DNA_methylase_A-5 | Domain | 48,025 | false | false | This domain is found in N-6 adenine-specific DNA methylases ( ) mainly from prokaryotes. These enzymes are responsible for the methylation of specific DNA sequences in order to prevent the host from digesting its own genome via its restriction enzymes. These methylases have the same sequence specificity as their corres... | [
"GO:0003677",
"GO:0008170"
] | [
"DNA binding",
"N-methyltransferase activity"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM"
] | [
"PF02384"
] | [
"N6_Mtase"
] | [
48025
] | 1 | [
"EC",
"GP"
] | [
"2.1.1.72",
"GenProp0455"
] | [
"EC:2.1.1.72",
"GP:GenProp0455"
] | 2 | [
"2ar0",
"2f8l",
"2okc",
"2y7c",
"2y7h",
"3khk",
"3lkd",
"3s1s",
"3ufb",
"4xqk",
"5ffj",
"5ybb",
"7bst",
"7bto",
"7btp",
"7btq",
"7btr",
"7eew",
"7lo5",
"7lvv",
"7vru",
"7vs4",
"8w0p",
"8w2p",
"8w2q"
] | 25 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1202,
45606,
262,
132,
823
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | DNA methylase, adenine-specific | DNA methylase, adenine-specific | DNA_methylase_A-5 | 3 |
IPR003358 | 3,358 | tRNA (guanine-N-7) methyltransferase, Trmb type | tRNA_(Gua-N-7)_MeTrfase_Trmb | Family | 31,037 | false | false | This entry represents tRNA (guanine-N-7) methyltransferase ( ), which catalyses the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. Capping of the pre-mRNA 5' end by addition a monomethylated guanosine cap (m(7)G) is an essential and the earliest modification in the biogenesis of mRNA [ ]. The reaction ... | [
"GO:0008176",
"GO:0006400"
] | [
"tRNA (guanine(46)-N7)-methyltransferase activity",
"tRNA modification"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PROFILE",
"PANTHER",
"NCBIFAM"
] | [
"PF02390",
"PS51625",
"PTHR23417",
"TIGR00091"
] | [
"Methyltransf_4",
"SAM_MT_TRMB",
"",
""
] | [
30858,
30381,
29031,
23362
] | 4 | [
"EC",
"EC",
"REACTOME"
] | [
"2.1.1",
"2.1.1.33",
"R-HSA-6782315"
] | [
"EC:2.1.1",
"EC:2.1.1.33",
"REACTOME:R-HSA-6782315"
] | 3 | [
"1yzh",
"2fca",
"2vdu",
"2vdv",
"3ckk",
"3dxx",
"3dxy",
"3dxz",
"7nyb",
"7nzi",
"7nzj",
"7ogj",
"7pl1",
"7u20",
"8cth",
"8cti",
"8d58",
"8d59",
"8d5b",
"8d9k",
"8d9l",
"8eg0",
"8h0n"
] | 23 | [
"PUB00006319",
"PUB00017356",
"PUB00040616",
"PUB00043301",
"PUB00044795",
"PUB00054125",
"PUB00057957",
"PUB00057958"
] | [
"7897657",
"12403464",
"16600901",
"18412263",
"17949828",
"12826405",
"16225687",
"21858014"
] | [
"Universal catalytic domain structure of AdoMet-dependent methyltransferases.",
"Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA.",
"Crystal structure of Bacillus subtilis TrmB, the tRNA (m7G46) methyltransferase.",
"Crystal structure of the methyltransferase dom... | [
1995,
2002,
2006,
2008,
2007,
2003,
2005,
2011
] | 8 | [] | [
"IPR025763",
"IPR055361"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
17,
24264,
6376,
380
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
12,
2,
3,
1,
1,
3,
3,
1,
10,
3,
1,
1,
30
] | 13 | true | Family | tRNA (guanine-N-7) methyltransferase, Trmb type | tRNA (guanine-N-7) methyltransferase, Trmb type | tRNA_(Gua-N-7)_MeTrfase_Trmb | 2 |
IPR003359 | 3,359 | Photosystem I Ycf4, assembly | PSI_Ycf4_assembly | Family | 14,909 | false | false | Photosystem I (PSI) is a large protein complex embedded within the photosynthetic thylakoid membrane formed by a core complex, peripheral light-harvesting complexes (LHCIs) and cofactors. It consists of 15 core and 4 LHCI subunits, ~150 chlorophylls (a and b) molecules, 2 phylloquinones, and 3 Fe4S4-clusters [ ]. The t... | [
"GO:0015979",
"GO:0009522",
"GO:0009579",
"GO:0016020"
] | [
"photosynthesis",
"photosystem I",
"thylakoid",
"membrane"
] | [
"biological_process",
"cellular_component",
"cellular_component",
"cellular_component"
] | 4 | [
"HAMAP",
"PFAM"
] | [
"MF_00437",
"PF02392"
] | [
"Ycf4",
"Ycf4"
] | [
13741,
14909
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00009534",
"PUB00014955",
"PUB00015098",
"PUB00015099",
"PUB00015100",
"PUB00015101",
"PUB00096753"
] | [
"9321389",
"10806238",
"11418848",
"9045660",
"9314531",
"10103064",
"29934511"
] | [
"The chloroplast ycf3 and ycf4 open reading frames of Chlamydomonas reinhardtii are required for the accumulation of the photosystem I complex.",
"The BtpA protein stabilizes the reaction center proteins of photosystem I in the cyanobacterium Synechocystis sp. PCC 6803 at low temperature.",
"Three-dimensional s... | [
1997,
2000,
2001,
1997,
1997,
1999,
2018
] | 7 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine metagenome"
] | [
369,
14539,
1
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
4,
6,
5
] | 3 | true | Family | Photosystem I Ycf4, assembly | Photosystem I Ycf4, assembly | PSI_Ycf4_assembly | 8 |
IPR003360 | 3,360 | US22-like | US22-like | Family | 1,934 | false | false | Herpesviruses are large and complex DNA viruses, widely found in nature. Human cytomegalovirus (HCMV), an important human pathogen, defines the betaherpesvirus family. Mouse cytomegalovirus (MCMV) and rat cytomegalovirus serve as biological model systems for HCMV. HCMV, MCMV, and rat CMV display the largest genomes amo... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02393"
] | [
"US22"
] | [
1934
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5357786",
"R-HSA-5357905",
"R-HSA-9609690",
"R-HSA-9610379",
"R-HSA-9686347",
"R-HSA-9833482"
] | [
"REACTOME:R-HSA-5357786",
"REACTOME:R-HSA-5357905",
"REACTOME:R-HSA-9609690",
"REACTOME:R-HSA-9610379",
"REACTOME:R-HSA-9686347",
"REACTOME:R-HSA-9833482"
] | 6 | [] | 0 | [
"PUB00009532",
"PUB00009533",
"PUB00045936",
"PUB00057479",
"PUB00153748",
"PUB00153749"
] | [
"1321206",
"10405367",
"12719548",
"21306995",
"24606703",
"9018122"
] | [
"Identification of homologues to the human cytomegalovirus US22 gene family in human herpesvirus 6.",
"Transcriptional analysis of the murine cytomegalovirus HindIII-I region: identification of a novel immediate-early gene region.",
"Role of murine cytomegalovirus US22 gene family members in replication in macr... | [
1992,
1999,
2003,
2011,
2014,
1997
] | 6 | [] | [] | 0 | 0 | null | [
"Chordata",
"Viruses"
] | [
528,
1406
] | 2 | [
"Homo sapiens"
] | [
6
] | 1 | true | Family | US22-like | US22-like | US22-like | 5 |
IPR003361 | 3,361 | Acetaldehyde dehydrogenase | Acetaldehyde_dehydrogenase | Family | 5,974 | false | false | The acetaldehyde dehydrogenase family ( ) of bacterial enzymes catalyse the formation of acetyl-CoA from acetaldehyde in the 3-hydroxyphenylpropinoate degradation pathway. It occurs as a late step in the meta-cleavage pathways of a variety of compounds, including catechol, biphenyl, toluene, salicylate [ ]. Members of ... | [
"GO:0008774",
"GO:0009056"
] | [
"acetaldehyde dehydrogenase (acetylating) activity",
"catabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"PIRSF",
"NCBIFAM"
] | [
"MF_01657",
"PIRSF015689",
"TIGR03215"
] | [
"Ac_ald_DH_ac",
"Actaldh_dh_actl",
"ac_ald_DH_ac"
] | [
5974,
5721,
5754
] | 3 | [
"EC",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"1.2.1.10",
"GenProp0708",
"GenProp1231",
"GenProp1425",
"GenProp1445",
"GenProp1497",
"GenProp1559",
"GenProp1762",
"PWY-5162",
"PWY-5436",
"PWY-5480",
"PWY-6587",
"PWY-7085",
"PWY-7180",
"PWY-8060",
"PWY-8062"
] | [
"EC:1.2.1.10",
"GP:GenProp0708",
"GP:GenProp1231",
"GP:GenProp1425",
"GP:GenProp1445",
"GP:GenProp1497",
"GP:GenProp1559",
"GP:GenProp1762",
"METACYC:PWY-5162",
"METACYC:PWY-5436",
"METACYC:PWY-5480",
"METACYC:PWY-6587",
"METACYC:PWY-7085",
"METACYC:PWY-7180",
"METACYC:PWY-8060",
"META... | 16 | [
"1nvm",
"4jn6",
"4lrs",
"4lrt",
"7z3s",
"8ih7"
] | 6 | [
"PUB00016385",
"PUB00042979"
] | [
"12764229",
"1732207"
] | [
"Crystal structure of a bifunctional aldolase-dehydrogenase: sequestering a reactive and volatile intermediate.",
"Nucleotide sequence and functional analysis of the complete phenol/3,4-dimethylphenol catabolic pathway of Pseudomonas sp. strain CF600."
] | [
2003,
1992
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Bathycoccus sp. RCC716 virus 2",
"Eukaryota",
"Halobacteriales",
"Sym plasmid",
"unclassified sequences"
] | [
5910,
1,
8,
13,
1,
41
] | 6 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Acetaldehyde dehydrogenase | Acetaldehyde dehydrogenase | Acetaldehyde_dehydrogenase | 8 |
IPR003362 | 3,362 | Bacterial sugar transferase | Bact_transf | Domain | 53,787 | false | false | This entry represents a conserved region from a number of different bacterial sugar transferases, involved in diverse biosynthesis pathways. Examples include galactosyl-P-P-undecaprenol synthetase ( ), which transfers galatose-1-phosphate to the lipid precursor undecaprenol phosphate in the first steps of O-polysacchar... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02397"
] | [
"Bac_transf"
] | [
53787
] | 1 | [] | [] | [] | 0 | [
"8e37",
"8g1n",
"8t53"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
294,
52654,
57,
2,
780
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Bacterial sugar transferase | Bacterial sugar transferase | Bact_transf | 8 |
IPR003366 | 3,366 | CUB-like domain | CUB-like_dom | Domain | 638 | false | false | This domain is found in a family of hypothetical Caenorhabditis elegans proteins. The aligned region has no known function nor do any of the proteins which possess it. However, this domain is related to the CUB domain ( ). The aligned region is approximately 130 amino acids long and contains two conserved cysteine resi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02408"
] | [
"CUB_2"
] | [
638
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Mucilaginibacter terrenus"
] | [
637,
1
] | 2 | [
"Caenorhabditis elegans"
] | [
64
] | 1 | true | Domain | CUB-like domain | CUB-like domain | CUB-like_dom | 1 |
IPR003367 | 3,367 | Thrombospondin, type 3-like repeat | Thrombospondin_3-like_rpt | Repeat | 15,698 | false | false | The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats [ ]. The repeat lacks defined secondary structure [ ]. This entry represents the type 3 thrombospondin repeat found in proteins of the ... | [
"GO:0005509",
"GO:0007155"
] | [
"calcium ion binding",
"cell adhesion"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF02412"
] | [
"TSP_3"
] | [
15698
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-216083",
"R-BTA-3000178",
"R-HSA-114608",
"R-HSA-186797",
"R-HSA-216083",
"R-HSA-3000170",
"R-HSA-3000178",
"R-HSA-5083635",
"R-HSA-5173214",
"R-HSA-8936459",
"R-MMU-114608",
"R-MMU-186797",
"R-MMU-216083",
"R-MMU-3000178",
"R-MMU-5173214",
"R-RNO-186797",
"R-RNO-216083",
"R... | [
"REACTOME:R-BTA-216083",
"REACTOME:R-BTA-3000178",
"REACTOME:R-HSA-114608",
"REACTOME:R-HSA-186797",
"REACTOME:R-HSA-216083",
"REACTOME:R-HSA-3000170",
"REACTOME:R-HSA-3000178",
"REACTOME:R-HSA-5083635",
"REACTOME:R-HSA-5173214",
"REACTOME:R-HSA-8936459",
"REACTOME:R-MMU-114608",
"REACTOME:R-M... | 18 | [
"1ux6",
"1yo8",
"2rhp",
"3fby",
"5wtl"
] | 5 | [
"PUB00006208",
"PUB00037903"
] | [
"2430973",
"15014436"
] | [
"The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins.",
"Structure of a thrombospondin C-terminal fragment reveals a novel calcium core in the type 3 repeats."
] | [
1986,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
166,
5500,
9897,
135
] | 4 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
18,
4,
23,
18,
15
] | 5 | true | Repeat | Thrombospondin, type 3-like repeat | Thrombospondin, type 3-like repeat | Thrombospondin_3-like_rpt | 1 |
IPR003368 | 3,368 | Polymorphic outer membrane protein repeat | POMP_repeat | Repeat | 4,782 | false | false | This repeat is found in several Chlamydia polymorphic membrane proteins [ ]. Chlamydia pneumoniae (Chlamydophila pneumoniae) is an obligate intracellular bacterium and a common human pathogen causing infection of the upper and lower respiratory tract. Proteins in this entry consist of there repeats at the N-terminal wh... | [] | [] | [] | 0 | [
"PFAM",
"NCBIFAM"
] | [
"PF02415",
"TIGR01376"
] | [
"Chlam_PMP",
"POMP_repeat"
] | [
3634,
3351
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00014841"
] | [
"11254597"
] | [
"Expression of Chlamydia pneumoniae polymorphic membrane protein family genes."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctOOe6",
"metagenomes"
] | [
583,
2514,
1549,
1,
135
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Repeat | Polymorphic outer membrane protein repeat | Polymorphic outer membrane protein repeat | POMP_repeat | 6 |
IPR003369 | 3,369 | Sec-independent protein translocase protein TatA/B/E | TatA/B/E | Family | 47,328 | false | false | This entry represents the related TatA, TatB and TatE proteins. Translocation of proteins across the two membranes of Gram-negative bacteria can be carried out via a number of routes. Most proteins marked for export carry a secretion signal at their N terminus, and are secreted by the general secretory pathway. The sig... | [
"GO:0015031"
] | [
"protein transport"
] | [
"biological_process"
] | 1 | [
"PFAM"
] | [
"PF02416"
] | [
"TatA_B_E"
] | [
47328
] | 1 | [] | [] | [] | 0 | [
"2l16",
"2lzr",
"2lzs",
"2mi2",
"2mn6",
"2mn7",
"7b7o",
"9dzz",
"9e01",
"9e02",
"9e03",
"9e04",
"9e06",
"9e07"
] | 14 | [
"PUB00007662",
"PUB00007663"
] | [
"9649434",
"10652088"
] | [
"Overlapping functions of components of a bacterial Sec-independent protein export pathway.",
"The Tat protein export pathway."
] | [
1998,
2000
] | 2 | [] | [
"IPR006312",
"IPR018448"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
960,
43266,
2124,
978
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
7,
3,
5,
17
] | 4 | true | Family | Sec-independent protein translocase protein TatA/B/E | Sec-independent protein translocase protein TatA/B/E | TatA/B/E | 7 |
IPR003370 | 3,370 | Chromate transporter | Chromate_transpt | Family | 28,852 | false | false | This entry represents chromate transporters (CHR) [ , ]. These proteins reduce chromate accumulation and are essential for chromate resistance. They are composed of one or two copies of this region. The short-chain CHR proteins (such as YwrB and YwrA) form heterodimer transporters which efflux chromate ions from the cy... | [
"GO:0015109",
"GO:0015703"
] | [
"chromate transmembrane transporter activity",
"chromate transport"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF02417"
] | [
"Chromate_transp"
] | [
28852
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00009527",
"PUB00009528",
"PUB00053869"
] | [
"2152903",
"2180932",
"19581367"
] | [
"Cloning, nucleotide sequence, and expression of the chromate resistance determinant of Pseudomonas aeruginosa plasmid pUM505.",
"Nucleotide sequence and expression of a plasmid-encoded chromate resistance determinant from Alcaligenes eutrophus.",
"Short-chain chromate ion transporter proteins from Bacillus sub... | [
1990,
1990,
2009
] | 3 | [] | [
"IPR014047"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Ochrobactrum phage POA1180",
"unclassified sequences"
] | [
61,
26571,
1944,
1,
275
] | 5 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | Chromate transporter | Chromate transporter | Chromate_transpt | 4 |
IPR003372 | 3,372 | Photosystem II PsbL | PSII_PsbL | Family | 13,758 | false | false | Oxygenic photosynthesis uses two multi-subunit photosystems (I and II) located in the cell membranes of cyanobacteria and in the thylakoid membranes of chloroplasts in plants and algae. Photosystem II (PSII) has a P680 reaction centre containing chlorophyll 'a' that uses light energy to carry out the oxidation (splitti... | [
"GO:0015979",
"GO:0009523",
"GO:0009539",
"GO:0016020"
] | [
"photosynthesis",
"photosystem II",
"photosystem II reaction center",
"membrane"
] | [
"biological_process",
"cellular_component",
"cellular_component",
"cellular_component"
] | 4 | [
"HAMAP",
"PFAM"
] | [
"MF_01317",
"PF02419"
] | [
"PSII_PsbL",
"PsbL"
] | [
13199,
13758
] | 2 | [
"GP"
] | [
"GenProp0661"
] | [
"GP:GenProp0661"
] | 1 | [
"1s5l",
"2axt",
"3a0b",
"3a0h",
"3jcu",
"3kzi",
"3wu2",
"4fby",
"4il6",
"4ixq",
"4ixr",
"4pbu",
"4pj0",
"4rvy",
"4tnh",
"4tni",
"4tnj",
"4tnk",
"4ub6",
"4ub8",
"4v62",
"4v82",
"4yuu",
"5b5e",
"5b66",
"5e79",
"5e7c",
"5gth",
"5gti",
"5h2f",
"5kaf",
"5kai"... | 162 | [
"PUB00015357",
"PUB00015358",
"PUB00015359",
"PUB00015366",
"PUB00015367",
"PUB00097583",
"PUB00152828"
] | [
"12518057",
"15100025",
"14871485",
"14979726",
"14686923",
"30076221",
"33846594"
] | [
"Crystal structure of oxygen-evolving photosystem II from Thermosynechococcus vulcanus at 3.7-A resolution.",
"The evolutionary development of the protein complement of photosystem 2.",
"The low molecular mass subunits of the photosynthetic supracomplex, photosystem II.",
"Photosystem II proteins PsbL and Psb... | [
2003,
2004,
2004,
2004,
2004,
2018,
2021
] | 7 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Thermoplasmatales archaeon SG8-52-4"
] | [
325,
13432,
1
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
3,
3,
2
] | 3 | true | Family | Photosystem II PsbL | Photosystem II PsbL | PSII_PsbL | 5 |
IPR003373 | 3,373 | Ferrous iron transport protein B | Fe2_transport_prot-B | Family | 14,123 | false | false | Escherichia coli has an iron(II) transport system (feo) which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this transport system and may play a role in the transport of ferrous iron. FeoB is a large 700-800 amino acid integral membrane... | [
"GO:0005525",
"GO:0015093",
"GO:0006826",
"GO:0016020"
] | [
"GTP binding",
"ferrous iron transmembrane transporter activity",
"iron ion transport",
"membrane"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"NCBIFAM"
] | [
"TIGR00437"
] | [
"feoB"
] | [
14123
] | 1 | [
"GP",
"REACTOME"
] | [
"GenProp1075",
"R-HSA-9638482"
] | [
"GP:GenProp1075",
"REACTOME:R-HSA-9638482"
] | 2 | [
"3hyr",
"3hyt",
"3i8s",
"3i8x",
"3i92",
"4q00",
"4q5i",
"4r98",
"5fh9"
] | 9 | [
"PUB00009526"
] | [
"8407793"
] | [
"Characterization of the ferrous iron uptake system of Escherichia coli."
] | [
1993
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctYaH2",
"unclassified sequences"
] | [
519,
13409,
29,
1,
165
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Ferrous iron transport protein B | Ferrous iron transport protein B | Fe2_transport_prot-B | 8 |
IPR003375 | 3,375 | Photosystem I PsaE, reaction centre subunit IV | PSI_PsaE | Family | 1,841 | false | false | PsaE is a 69 amino acid polypeptide from photosystem I present on the stromal side of the thylakoid membrane. The structure is comprised of a well-defined five-stranded β-sheet similar to SH3 domains [ ]. This subunit may form complexes with ferredoxin and ferredoxin-oxidoreductase in the photosystem I reaction centre. | [
"GO:0015979",
"GO:0009522",
"GO:0009538"
] | [
"photosynthesis",
"photosystem I",
"photosystem I reaction center"
] | [
"biological_process",
"cellular_component",
"cellular_component"
] | 3 | [
"HAMAP",
"PFAM",
"PANTHER"
] | [
"MF_00613",
"PF02427",
"PTHR34549"
] | [
"PSI_PsaE",
"PSI_PsaE",
""
] | [
454,
1821,
1822
] | 3 | [
"GP"
] | [
"GenProp0660"
] | [
"GP:GenProp0660"
] | 1 | [
"1gxi",
"1jb0",
"1pse",
"1psf",
"1qp2",
"1qp3",
"2o01",
"2wsc",
"2wse",
"2wsf",
"3lw5",
"3pcq",
"4fe1",
"4kt0",
"4l6v",
"4rku",
"4xk8",
"4y28",
"5l8r",
"5oy0",
"5zf0",
"5zgb",
"5zgh",
"5zji",
"6fos",
"6hqb",
"6igz",
"6ijj",
"6ijo",
"6jeo",
"6jo5",
"6jo6"... | 151 | [
"PUB00009524"
] | [
"8193119"
] | [
"Three-dimensional solution structure of PsaE from the cyanobacterium Synechococcus sp. strain PCC 7002, a photosystem I protein that shows structural homology with SH3 domains."
] | [
1994
] | 1 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Eukaryota",
"Viruses",
"marine metagenome"
] | [
391,
1445,
4,
1
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
11,
3,
7
] | 3 | true | Family | Photosystem I PsaE, reaction centre subunit IV | Photosystem I PsaE, reaction centre subunit IV | PSI_PsaE | 3 |
IPR003376 | 3,376 | Peridinin-chlorophyll A binding protein | Peridinin-chlorophyll-bd_prot | Family | 603 | false | false | Peridinin-chlorophyll-protein, a water-soluble light-harvesting complex that has a blue-green absorbing carotenoid as its main pigment, is present in most photosynthetic dinoflagellates. These proteins are composed of two similar repeated domains. These domains constitute a scaffold with pseudo-twofold symmetry surroun... | [
"GO:0016168",
"GO:0030076"
] | [
"chlorophyll binding",
"light-harvesting complex"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF02429"
] | [
"PCP"
] | [
603
] | 1 | [] | [] | [] | 0 | [
"1ppr",
"2c9e",
"2x1z",
"2x20",
"2x21",
"3iis",
"3iiu",
"8ov5",
"8ow6"
] | 9 | [
"PUB00009523"
] | [
"8650577"
] | [
"Structural basis of light harvesting by carotenoids: peridinin-chlorophyll-protein from Amphidinium carterae."
] | [
1996
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Flavobacteriaceae",
"termite gut metagenome"
] | [
594,
7,
2
] | 3 | [] | [] | 0 | true | Family | Peridinin-chlorophyll A binding protein | Peridinin-chlorophyll A binding protein | Peridinin-chlorophyll-bd_prot | 8 |
IPR003377 | 3,377 | Cornichon | Cornichon | Family | 8,846 | false | false | This entry represents a group of conserved proteins from fungi, plants to animals. They are transmembrane proteins. Proteins in this entry include budding yeast Erv14/15, Drosophila Cornichon and human CNIH1/2/3/4. | [
"GO:0016192"
] | [
"vesicle-mediated transport"
] | [
"biological_process"
] | 1 | [
"PFAM",
"SMART"
] | [
"PF03311",
"SM01398"
] | [
"Cornichon",
"Cornichon"
] | [
8829,
8666
] | 2 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC01042",
"R-BTA-204005",
"R-BTA-5694530",
"R-CEL-204005",
"R-CEL-5694530",
"R-DME-204005",
"R-DME-5694530",
"R-DRE-204005",
"R-DRE-5694530",
"R-HSA-204005",
"R-HSA-5694530",
"R-MMU-204005",
"R-MMU-5694530",
"R-RNO-204005",
"R-RNO-5694530",
"R-XTR-204005",
"R-XTR-5694530"
] | [
"PROSITEDOC:PDOC01042",
"REACTOME:R-BTA-204005",
"REACTOME:R-BTA-5694530",
"REACTOME:R-CEL-204005",
"REACTOME:R-CEL-5694530",
"REACTOME:R-DME-204005",
"REACTOME:R-DME-5694530",
"REACTOME:R-DRE-204005",
"REACTOME:R-DRE-5694530",
"REACTOME:R-HSA-204005",
"REACTOME:R-HSA-5694530",
"REACTOME:R-MMU... | 17 | [
"6peq",
"6ucb",
"6ud4",
"6ud8",
"7ldd",
"7lde",
"7lep",
"7oca",
"7oce",
"7ocf",
"8ss2",
"8ss3",
"8ss4",
"8ss6",
"8ss7",
"8ssa",
"8ssb"
] | 17 | [
"PUB00006654",
"PUB00018057",
"PUB00078814",
"PUB00078815",
"PUB00078816"
] | [
"7540118",
"9732282",
"16396907",
"17298976",
"17607000"
] | [
"cornichon and the EGF receptor signaling process are necessary for both anterior-posterior and dorsal-ventral pattern formation in Drosophila.",
"Transport of axl2p depends on erv14p, an ER-vesicle protein related to the Drosophila cornichon gene product.",
"Drosophila Cornichon acts as cargo receptor for ER e... | [
1995,
1998,
2006,
2007,
2007
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
8845,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
12,
1,
10,
4,
16,
14,
1,
2,
20,
2,
2,
10
] | 12 | true | Family | Cornichon | Cornichon | Cornichon | 2 |
IPR003378 | 3,378 | Fringe-like, glycosyltransferase domain | Fringe-like_glycosylTrfase | Domain | 16,530 | false | false | This entry represents the glycosyltransferase domain found in fringe proteins from Drosophila and its orthologues from mammals LFNG/RFNG/DFNG and glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (C1GALT1). The Notch receptor is a large, cell surface transmembrane protein involved in a wide variety of d... | [
"GO:0016757",
"GO:0016020"
] | [
"glycosyltransferase activity",
"membrane"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF02434"
] | [
"Fringe"
] | [
16530
] | 1 | [
"CAZY",
"EC",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"GT31",
"2.4.1",
"GenProp1712",
"R-BTA-913709",
"R-CEL-913709",
"R-DME-913709",
"R-GGA-913709",
"R-HSA-1912420",
"R-HSA-5083630",
"R-HSA-5083632",
"R-HSA-5083635",
"R-HSA-5173214",
"R-HSA-913709",
"R-HSA-9824272",
"R-HSA-9831926",
"R-MMU-5173214",
"R-MMU-913709",
"R-RNO-913709"
] | [
"CAZY:GT31",
"EC:2.4.1",
"GP:GenProp1712",
"REACTOME:R-BTA-913709",
"REACTOME:R-CEL-913709",
"REACTOME:R-DME-913709",
"REACTOME:R-GGA-913709",
"REACTOME:R-HSA-1912420",
"REACTOME:R-HSA-5083630",
"REACTOME:R-HSA-5083632",
"REACTOME:R-HSA-5083635",
"REACTOME:R-HSA-5173214",
"REACTOME:R-HSA-913... | 18 | [
"2j0a",
"2j0b",
"7q4i"
] | 3 | [
"PUB00009522",
"PUB00013432",
"PUB00042659",
"PUB00042660",
"PUB00042661",
"PUB00042662",
"PUB00042663",
"PUB00042664",
"PUB00042665",
"PUB00042666"
] | [
"10899003",
"10221902",
"12417415",
"14570055",
"7954826",
"12001066",
"9121551",
"16221665",
"16899492",
"11673471"
] | [
"The notch signalling regulator fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DXD.",
"Notch signaling: cell fate control and signal integration in development.",
"Modulation of receptor signaling by glycosylation: fringe is an O-fucose-beta1,3-N-acetylglucosaminyltransf... | [
2000,
1999,
2002,
2003,
1994,
2002,
1997,
2005,
2006,
2002
] | 10 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pithoviruses",
"Pseudomonadati",
"metagenomes"
] | [
16498,
6,
3,
23
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
1,
11,
35,
27,
21,
8,
3,
3,
27,
2
] | 10 | true | Domain | Fringe-like, glycosyltransferase domain | Fringe-like, glycosyltransferase domain | Fringe-like_glycosylTrfase | 6 |
IPR003379 | 3,379 | Carboxylase, conserved domain | Carboxylase_cons_dom | Domain | 24,841 | false | false | This domain represents a conserved region in pyruvate carboxylase (PYC) ( ), oxaloacetate decarboxylase alpha chain (OADA) ( ), and transcarboxylase 5s subunit ( ). The domain is found adjacent to the HMGL-like domain ( ) and often close to the biotin_lipoyl domain ( ) of biotin requiring enzymes. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02436"
] | [
"PYC_OADA"
] | [
24841
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"RE... | [
"6.4.1.1",
"PWY-6142",
"PWY-6146",
"PWY-8086",
"R-BTA-196780",
"R-BTA-70263",
"R-BTA-70268",
"R-CEL-196780",
"R-CEL-70263",
"R-CEL-70268",
"R-HSA-196780",
"R-HSA-3371599",
"R-HSA-70263",
"R-HSA-70268",
"R-MMU-196780",
"R-MMU-70263",
"R-MMU-70268",
"R-RNO-196780",
"R-RNO-70263",
... | [
"EC:6.4.1.1",
"METACYC:PWY-6142",
"METACYC:PWY-6146",
"METACYC:PWY-8086",
"REACTOME:R-BTA-196780",
"REACTOME:R-BTA-70263",
"REACTOME:R-BTA-70268",
"REACTOME:R-CEL-196780",
"REACTOME:R-CEL-70263",
"REACTOME:R-CEL-70268",
"REACTOME:R-HSA-196780",
"REACTOME:R-HSA-3371599",
"REACTOME:R-HSA-70263... | 26 | [
"1rqb",
"1rqe",
"1rqh",
"1rr2",
"1s3h",
"1u5j",
"2nx9",
"2qf7",
"3bg3",
"3bg5",
"3bg9",
"3hb9",
"3hbl",
"3ho8",
"3tw6",
"3tw7",
"4hnt",
"4hnu",
"4hnv",
"4jx4",
"4jx5",
"4jx6",
"4loc",
"4m6v",
"4mfd",
"4mfe",
"4mim",
"4qsh",
"4qsk",
"4qsl",
"5ks8",
"5vyw"... | 55 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
306,
19830,
4415,
290
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
2,
3,
4,
1,
8,
1,
5,
2,
1
] | 9 | true | Domain | Carboxylase, conserved domain | Carboxylase, conserved domain | Carboxylase_cons_dom | 9 |
IPR003380 | 3,380 | SKI/SNO/DAC domain | SKI/SNO/DAC | Domain | 8,971 | false | false | This domain is about 100 amino acids long and contains a conserved CLPQ motif. The c-ski proto-oncogene has been shown to influence proliferation, morphological transformation and myogenic differentiation [ ]. Sno, a Ski proto-oncogene homologue, is expressed in two isoforms and plays a role in the response to prolifer... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02437"
] | [
"Ski_Sno_DHD"
] | [
8971
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-201451",
"R-HSA-2173795",
"R-MMU-201451",
"R-MMU-2173795"
] | [
"REACTOME:R-HSA-201451",
"REACTOME:R-HSA-2173795",
"REACTOME:R-MMU-201451",
"REACTOME:R-MMU-2173795"
] | 4 | [
"1l8r",
"1sbx",
"3eq5"
] | 3 | [
"PUB00009521",
"PUB00020342",
"PUB00020343"
] | [
"7999783",
"7821215",
"11290302"
] | [
"Cloning and expression of the axolotl proto-oncogene ski.",
"dachshund encodes a nuclear protein required for normal eye and leg development in Drosophila.",
"The Drosophila sex determination hierarchy modulates wingless and decapentaplegic signaling to deploy dachshund sex-specifically in the genital imaginal... | [
1995,
1994,
2001
] | 3 | [] | [
"IPR047315"
] | 0 | 1 | 0 | [
"Avian erythroblastosis virus (strain Sloan-Kettering)",
"Clostridium innocuum",
"Metazoa"
] | [
1,
1,
8969
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
75,
21,
15,
22,
25
] | 6 | true | Domain | SKI/SNO/DAC domain | SKI/SNO/DAC domain | SKI/SNO/DAC | 4 |
IPR003381 | 3,381 | Shutoff protein L4 | L4 | Family | 559 | false | false | The late 100kDa protein (also known as L4) inhibits host translation while promoting late viral translation by ribosome shunting [ ]. It blocks host cap-dependent translation by binding to eIF4G, displacing MKNK1 from cap initiation complexes and preventing EIF4E phosphorylation [ ]. | [
"GO:0003723",
"GO:0039657",
"GO:0039704"
] | [
"RNA binding",
"symbiont-mediated suppression of host gene expression",
"viral translational shunt"
] | [
"molecular_function",
"biological_process",
"biological_process"
] | 3 | [
"HAMAP",
"PFAM"
] | [
"MF_04060",
"PF02438"
] | [
"ADV_SHUT",
"Adeno_100"
] | [
489,
559
] | 2 | [] | [] | [] | 0 | [
"9ivw",
"9ivx"
] | 2 | [
"PUB00087129",
"PUB00087130"
] | [
"15827182",
"15220445"
] | [
"Regulation of translation by ribosome shunting through phosphotyrosine-dependent coupling of adenovirus protein 100k to viral mRNAs.",
"Structural basis for competitive inhibition of eIF4G-Mnk1 interaction by the adenovirus 100-kilodalton protein."
] | [
2005,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Adenoviridae"
] | [
559
] | 1 | [] | [] | 0 | true | Family | Shutoff protein L4 | Shutoff protein L4 | L4 | 1 |
IPR003382 | 3,382 | Flavoprotein | Flavoprotein | Domain | 53,623 | false | false | This entry contains a diverse range of flavoprotein enzymes, including epidermin biosynthesis protein, EpiD, which has been shown to be a flavoprotein that binds FMN [ ]. This enzyme catalyzes the removal of two reducing equivalents from the cysteine residue of the C-terminal meso-lanthionine of epidermin to form a --C... | [
"GO:0003824"
] | [
"catalytic activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF02441"
] | [
"Flavoprotein"
] | [
53623
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-196783",
"R-HSA-196783",
"R-MMU-196783",
"R-SCE-196783",
"R-SPO-499943"
] | [
"REACTOME:R-DDI-196783",
"REACTOME:R-HSA-196783",
"REACTOME:R-MMU-196783",
"REACTOME:R-SCE-196783",
"REACTOME:R-SPO-499943"
] | 5 | [
"1e20",
"1g5q",
"1g63",
"1mvl",
"1mvn",
"1p3y",
"1qzu",
"1sbz",
"2ejb",
"3lqk",
"3mcu",
"3qjg",
"3wis",
"3zqu",
"4mwg",
"4rhe",
"4rhf",
"4zaf",
"4zag",
"4zal",
"4zan",
"4zav",
"4zaw",
"4zax",
"4zay",
"4zaz",
"5h75",
"6eoa",
"6jdd",
"6jls",
"6m8t",
"6m8u"... | 44 | [
"PUB00009518",
"PUB00009519",
"PUB00009520",
"PUB00160292"
] | [
"1644762",
"8345520",
"8181743",
"32761275"
] | [
"Purification and characterization of EpiD, a flavoprotein involved in the biosynthesis of the lantibiotic epidermin.",
"Cloning, DNA sequence, functional analysis and transcriptional regulation of the genes encoding dipicolinic acid synthetase required for sporulation in Bacillus subtilis.",
"PAD1 encodes phen... | [
1992,
1993,
1994,
2020
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1795,
43570,
7354,
15,
889
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
8,
1,
3,
1,
2,
7,
7,
2,
1,
8,
4,
1,
9
] | 13 | true | Domain | Flavoprotein | Flavoprotein | Flavoprotein | 9 |
IPR003383 | 3,383 | Circovirus capsid protein | Circovirus_capsid | Family | 5,356 | false | false | Circoviruses are small circular single stranded viruses. This family is the capsid protein from viruses such as Porcine circovirus [ ] and Beak and feather disease virus . | [
"GO:0019069"
] | [
"viral capsid assembly"
] | [
"biological_process"
] | 1 | [
"PFAM"
] | [
"PF02443"
] | [
"Circo_capsid"
] | [
5356
] | 1 | [] | [] | [] | 0 | [
"3jci",
"3r0r",
"5j09",
"5j36",
"5j37",
"5zbo",
"5zju",
"6dzu",
"6e2r",
"6e2x",
"6e2z",
"6e30",
"6e32",
"6e34",
"6e39",
"6l62",
"6lm3",
"6ola",
"6rpk",
"6rpl",
"6rpo"
] | 21 | [
"PUB00009517"
] | [
"9573301"
] | [
"Nucleotide sequence of porcine circovirus associated with postweaning multisystemic wasting syndrome in pigs."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Candidatus Magnetobacterium casense",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
5,
13,
5336,
2
] | 4 | [] | [] | 0 | true | Family | Circovirus capsid protein | Circovirus capsid protein | Circovirus_capsid | 4 |
IPR003384 | 3,384 | Hepatitis E virus Orf2, capsid | HEV_Orf2 | Family | 821 | false | false | The Hepatitis E virus(HEV) genome is a single-stranded, positive-sense RNA molecule of approximately 7.5 kb [ ]. Three open reading frames (ORF) were identified within the HEV genome: ORF1 encodes nonstructural proteins, ORF2 encodes the putative structural protein(s), and ORF3 encodes a protein of unknown function. OR... | [
"GO:0030430"
] | [
"host cell cytoplasm"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF02444"
] | [
"HEV_ORF1"
] | [
821
] | 1 | [] | [] | [] | 0 | [
"2zzq"
] | 1 | [
"PUB00009515",
"PUB00009516"
] | [
"10449466",
"1926770"
] | [
"Antigenic domains of the open reading frame 2-encoded protein of hepatitis E virus.",
"Hepatitis E virus (HEV): molecular cloning and sequencing of the full-length viral genome."
] | [
1999,
1991
] | 2 | [] | [] | 0 | 0 | null | [
"Hepeviridae"
] | [
821
] | 1 | [] | [] | 0 | true | Family | Hepatitis E virus Orf2, capsid | Hepatitis E virus Orf2, capsid | HEV_Orf2 | 4 |
IPR003385 | 3,385 | Glycoside hydrolase, family 77 | Glyco_hydro_77 | Family | 18,427 | false | false | 4-alpha-glucanotransferases ( ) belong to the glycoside hydrolase family 77 . They transfer a segment of a (1,4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1,4)-alpha-D-glucan [ ]. 4-alpha-glucanotransferases from prokaryotes are known as amylomaltases and those from plants, including a... | [
"GO:0004134",
"GO:0005975"
] | [
"4-alpha-glucanotransferase activity",
"carbohydrate metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PANTHER",
"NCBIFAM"
] | [
"PF02446",
"PTHR32438",
"TIGR00217"
] | [
"Glyco_hydro_77",
"",
"malQ"
] | [
18416,
15709,
14672
] | 3 | [
"CAZY",
"EC",
"GP",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC"
] | [
"GH77",
"2.4.1.25",
"GenProp0168",
"GenProp1412",
"GenProp1726",
"PWY-6724",
"PWY-6737",
"PWY-7238"
] | [
"CAZY:GH77",
"EC:2.4.1.25",
"GP:GenProp0168",
"GP:GenProp1412",
"GP:GenProp1726",
"METACYC:PWY-6724",
"METACYC:PWY-6737",
"METACYC:PWY-7238"
] | 8 | [
"1cwy",
"1esw",
"1fp8",
"1fp9",
"1tz7",
"1x1n",
"2owc",
"2oww",
"2owx",
"2x1i",
"4s3p",
"4s3q",
"4s3r",
"5b68",
"5cpq",
"5cps",
"5cpt",
"5cq1",
"5csu",
"5csy",
"5jiw",
"5jjh",
"6lx1",
"6lx2",
"6m6t",
"7cov",
"9u5l"
] | 27 | [
"PUB00009514",
"PUB00075631"
] | [
"7678257",
"26006747"
] | [
"Disproportionating enzyme (4-alpha-glucanotransferase; EC 2.4.1.25) of potato. Purification, molecular cloning, and potential role in starch metabolism.",
"In silico analysis of family GH77 with focus on amylomaltases from borreliae and disproportionating enzymes DPE2 from plants and bacteria."
] | [
1993,
2015
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
246,
15976,
1958,
3,
244
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
11,
1,
6,
37
] | 4 | true | Family | Glycoside hydrolase, family 77 | Glycoside hydrolase, family 77 | Glyco_hydro_77 | 3 |
IPR003386 | 3,386 | Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase | LACT/PDAT_acylTrfase | Family | 13,824 | false | false | This entry represents a group of lipid metabolising enzymes, including LACT and LPLA2 from humans, and PDAT from plants. Lecithin:cholesterol acyltransferase (LACT), also known as phosphatidylcholine-sterol acyltransferase ( ), is involved in extracellular metabolism of plasma lipoproteins, including cholesterol. It es... | [
"GO:0008374",
"GO:0006629"
] | [
"O-acyltransferase activity",
"lipid metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF02450"
] | [
"LCAT"
] | [
13824
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.3.1",
"R-BTA-1483115",
"R-CFA-1483115",
"R-HSA-1483115",
"R-HSA-8964058",
"R-MMU-1483115",
"R-MMU-8964058",
"R-RNO-1483115",
"R-RNO-8964058",
"R-SCE-1483115",
"R-SCE-8964058"
] | [
"EC:2.3.1",
"REACTOME:R-BTA-1483115",
"REACTOME:R-CFA-1483115",
"REACTOME:R-HSA-1483115",
"REACTOME:R-HSA-8964058",
"REACTOME:R-MMU-1483115",
"REACTOME:R-MMU-8964058",
"REACTOME:R-RNO-1483115",
"REACTOME:R-RNO-8964058",
"REACTOME:R-SCE-1483115",
"REACTOME:R-SCE-8964058"
] | 11 | [
"4x90",
"4x91",
"4x92",
"4x93",
"4x94",
"4x95",
"4x96",
"4x97",
"4xwg",
"4xx1",
"5bv7",
"5txf",
"6mtw",
"6mvd",
"9mxz"
] | 15 | [
"PUB00055421",
"PUB00093993",
"PUB00093994",
"PUB00093995"
] | [
"12963726",
"26195816",
"8326012",
"25727495"
] | [
"Schizosaccharomyces pombe cells deficient in triacylglycerols synthesis undergo apoptosis upon entry into the stationary phase.",
"The high-resolution crystal structure of human LCAT.",
"Fish eye syndrome: a molecular defect in the lecithin-cholesterol acyltransferase (LCAT) gene associated with normal alpha-L... | [
2003,
2015,
1993,
2015
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Stenosarchaea group",
"Viruses",
"unclassified sequences"
] | [
1750,
12012,
9,
10,
43
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
25,
1,
2,
3,
12,
5,
1,
40,
11,
2,
1,
108
] | 12 | true | Family | Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase | Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase | LACT/PDAT_acylTrfase | 1 |
IPR003387 | 3,387 | Nodulin | Nodulin | Family | 62 | false | false | Nodulin is a plant protein of unknown function. It is induced during nodulation in legume roots after rhizobium infection. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02451"
] | [
"Nodulin"
] | [
62
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"indigoferoid/millettioid clade"
] | [
62
] | 1 | [] | [] | 0 | true | Family | Nodulin | Nodulin | Nodulin | 7 |
IPR003390 | 3,390 | DNA integrity scanning protein, DisA, N-terminal | DNA_integrity_scan_DisA_N | Domain | 15,615 | false | false | Cyclic di-AMP (c-di-AMP) is a bacterial secondary messenger molecule, which is associated with various physiological functions. It is involved in several important cellular processes, such as cell wall metabolism, maintenance of DNA integrity, ion transport, transcription regulation, and allosteric regulation of enzyme... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE"
] | [
"PF02457",
"PS51794"
] | [
"DAC",
"DAC"
] | [
15356,
15575
] | 2 | [
"EC"
] | [
"2.7.7.85"
] | [
"EC:2.7.7.85"
] | 1 | [
"2fb5",
"3c1y",
"3c1z",
"3c21",
"3c23",
"4rv7",
"4yvz",
"4yxj",
"4yxm",
"6gyw",
"6gyx",
"6gyy",
"6huw",
"6hvl",
"6hvm",
"6hvn",
"7dfx",
"7dg0",
"7l8n",
"7ojs",
"7olh",
"7y0d",
"8c4j",
"8c4m",
"8c4n",
"8c4o",
"8c4p",
"8c4q",
"8c4r",
"8ofg",
"8ofh",
"8ofj"... | 71 | [
"PUB00044227",
"PUB00080710",
"PUB00084192",
"PUB00084262",
"PUB00084263"
] | [
"18439896",
"23812326",
"26441857",
"25605729",
"26014055"
] | [
"Structural biochemistry of a bacterial checkpoint protein reveals diadenylate cyclase activity regulated by DNA recombination intermediates.",
"Cyclic di-AMP: another second messenger enters the fray.",
"Functional analysis of the sporulation-specific diadenylate cyclase CdaS in Bacillus thuringiensis.",
"St... | [
2008,
2013,
2015,
2015,
2015
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
746,
14567,
51,
2,
249
] | 5 | [] | [] | 0 | true | Domain | DNA integrity scanning protein, DisA, N-terminal | DNA integrity scanning protein, DisA, N-terminal | DNA_integrity_scan_DisA_N | 1 |
IPR003391 | 3,391 | Adenoviral preterminal protein | Adeno_preterminal | Family | 595 | false | false | The adenovirus terminal protein precursor or preterminal protein (pTP) functions as a primer for the initiation of virus DNA replication. It forms a heterodimer with Ad DNA polymerase (pol) [ , ]. pTP is processed at two sites by the virus-encoded protease to yield mature terminal protein (TP) via an intermediate (iTP)... | [
"GO:0003677",
"GO:0006260"
] | [
"DNA binding",
"DNA replication"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"PFAM"
] | [
"MF_04061",
"PF02459"
] | [
"ADV_TERM",
"Adeno_terminal"
] | [
406,
595
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00076657",
"PUB00076658",
"PUB00076659"
] | [
"12799455",
"15273278",
"9261355"
] | [
"DNA binding properties of the adenovirus DNA replication priming protein pTP.",
"The adenovirus priming protein pTP contributes to the kinetics of initiation of DNA replication.",
"Role of preterminal protein processing in adenovirus replication."
] | [
2003,
2004,
1997
] | 3 | [] | [] | 0 | 0 | null | [
"Adenoviridae"
] | [
595
] | 1 | [] | [] | 0 | true | Family | Adenoviral preterminal protein | Adenoviral preterminal protein | Adeno_preterminal | 5 |
IPR003392 | 3,392 | Patched domain-containing protein, SSD domain | PTHD_SSD | Domain | 7,804 | false | false | This entry represents the sterol-sensing domain (SSD) of patched domain-containing proteins 1, 3, 4 and 18. PTCHD3 may play a role in sperm development or sperm function [ ], however, it may not play an essential role in spermatogenesis or male fertility [ ]. PTCH1 is required for the development and function of the th... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF02460"
] | [
"Patched"
] | [
7804
] | 1 | [] | [] | [] | 0 | [
"8v0g",
"8v12",
"8v1g"
] | 3 | [
"PUB00052179",
"PUB00071977",
"PUB00078868",
"PUB00155957",
"PUB00155958",
"PUB00155959",
"PUB00155960",
"PUB00155961"
] | [
"19563754",
"12372301",
"8049466",
"17904097",
"21439084",
"25296753",
"27007844",
"36769003"
] | [
"Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol.",
"Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched.",
"Cell patterning in the Drosophila segment: engrailed and wingless antigen distributions in seg... | [
2009,
2002,
1993,
2007,
2011,
2014,
2016,
2023
] | 8 | [
"IPR000731"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Methanobacteriati",
"ecological metagenomes"
] | [
93,
7685,
19,
7
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
27,
11,
1,
8,
6,
7
] | 6 | true | Domain | Patched domain-containing protein, SSD domain | Patched domain-containing protein, SSD domain | PTHD_SSD | 1 |
IPR003394 | 3,394 | Porin, opacity type | Porin_opacity | Domain | 1,008 | false | false | Pathogenic Neisseria spp. possess a repertoire of phase-variable opacity proteins that mediate various pathogen/host cell interactions [ ]. These proteins are integral membrane proteins related to other porins and the Haemophilus influenzae OpA protein. | [
"GO:0015288",
"GO:0016020"
] | [
"porin activity",
"membrane"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF02462"
] | [
"Opacity"
] | [
1008
] | 1 | [
"REACTOME"
] | [
"R-HSA-202733"
] | [
"REACTOME:R-HSA-202733"
] | 1 | [
"1p4t",
"2maf",
"2mlh",
"8qwq"
] | 4 | [
"PUB00009510"
] | [
"10036728"
] | [
"The role of neisserial Opa proteins in interactions with host cells."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
1004,
4
] | 2 | [] | [] | 0 | true | Domain | Porin, opacity type | Porin, opacity type | Porin_opacity | 7 |
IPR003395 | 3,395 | RecF/RecN/SMC, N-terminal | RecF/RecN/SMC_N | Domain | 99,009 | false | false | This domain is found at the N terminus of structural maintenance of chromosomes (SMC) proteins, which function together with other proteins in a range of chromosomal transactions, including chromosome condensation, sister-chromatid cohesion, recombination, DNA repair and epigenetic silencing of gene expression [ ]. The... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02463"
] | [
"SMC_N"
] | [
99009
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-2467813",
"R-BTA-2468052",
"R-BTA-2470946",
"R-BTA-2500257",
"R-BTA-3108214",
"R-CEL-2299718",
"R-CEL-2468052",
"R-CEL-2470946",
"R-CEL-2500257",
"R-CEL-3108214",
"R-DDI-2299718",
"R-DDI-2468052",
"R-DDI-2470946",
"R-DDI-2500257",
"R-DDI-2514853",
"R-DDI-3108214",
"R-HSA-12216... | [
"REACTOME:R-BTA-2467813",
"REACTOME:R-BTA-2468052",
"REACTOME:R-BTA-2470946",
"REACTOME:R-BTA-2500257",
"REACTOME:R-BTA-3108214",
"REACTOME:R-CEL-2299718",
"REACTOME:R-CEL-2468052",
"REACTOME:R-CEL-2470946",
"REACTOME:R-CEL-2500257",
"REACTOME:R-CEL-3108214",
"REACTOME:R-DDI-2299718",
"REACTOM... | 47 | [
"1e69",
"1ii8",
"1w1w",
"1xew",
"1xex",
"2o5v",
"3kta",
"3qkr",
"3qks",
"3zgx",
"4aby",
"4ad8",
"4i99",
"4ux3",
"5h66",
"5h67",
"5h68",
"5xei",
"5xg3",
"5xns",
"5z67",
"5z68",
"5z69",
"6qj0",
"6qj1",
"6qj2",
"6qj4",
"6qpq",
"6qpw",
"6wg3",
"6wge",
"6yuf"... | 75 | [
"PUB00007543",
"PUB00020349",
"PUB00154981"
] | [
"11983169",
"10429180",
"23653445"
] | [
"Molecular architecture of SMC proteins and the yeast cohesin complex.",
"Structural maintenance of chromosomes (SMC) proteins: conserved molecular properties for multiple biological functions.",
"Factors required for activation of urease as a virulence determinant in Cryptococcus neoformans."
] | [
2002,
1999,
2013
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1081,
66736,
29566,
191,
1435
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
40,
8,
17,
33,
2,
43,
27,
5,
24,
27,
5,
5,
70
] | 13 | true | Domain | RecF/RecN/SMC, N-terminal | RecF/RecN/SMC, N-terminal | RecF/RecN/SMC_N | 9 |
IPR003398 | 3,398 | Photosystem II PsbN | PSII_PsbN | Family | 15,370 | false | false | Oxygenic photosynthesis uses two multi-subunit photosystems (I and II) located in the cell membranes of cyanobacteria and in the thylakoid membranes of chloroplasts in plants and algae. Photosystem II (PSII) has a P680 reaction centre containing chlorophyll 'a' that uses light energy to carry out the oxidation (splitti... | [
"GO:0015979",
"GO:0016020"
] | [
"photosynthesis",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"HAMAP",
"PFAM",
"PANTHER"
] | [
"MF_00293",
"PF02468",
"PTHR35326"
] | [
"PSII_PsbN",
"PsbN",
""
] | [
15180,
15368,
15278
] | 3 | [
"GP"
] | [
"GenProp0661"
] | [
"GP:GenProp0661"
] | 1 | [] | 0 | [
"PUB00015357",
"PUB00015358",
"PUB00015359",
"PUB00095227",
"PUB00097583",
"PUB00152828"
] | [
"12518057",
"15100025",
"14871485",
"24619613",
"30076221",
"33846594"
] | [
"Crystal structure of oxygen-evolving photosystem II from Thermosynechococcus vulcanus at 3.7-A resolution.",
"The evolutionary development of the protein complement of photosystem 2.",
"The low molecular mass subunits of the photosynthetic supracomplex, photosystem II.",
"PsbN is required for assembly of the... | [
2003,
2004,
2004,
2014,
2018,
2021
] | 6 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Caudoviricetes",
"Eukaryota",
"marine sediment metagenome"
] | [
361,
11,
14997,
1
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
3,
2,
2
] | 3 | true | Family | Photosystem II PsbN | Photosystem II PsbN | PSII_PsbN | 1 |
IPR003399 | 3,399 | Mce/MlaD | Mce/MlaD | Domain | 70,180 | false | false | This domain is found in all 24 mce genes associated with the four mammalian cell entry (mce) operons of Mycobacterium tuberculosis and MlaD proteins from other Actinomycetales [ , ]. The archetype (mce1A, Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage [ ]. The domain i... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02470"
] | [
"MlaD"
] | [
70180
] | 1 | [] | [] | [] | 0 | [
"5uvn",
"5uw2",
"5uw8",
"6ic4",
"6kz3",
"6kz4",
"6v0c",
"6v0d",
"6v0e",
"6v0f",
"6v0g",
"6v0h",
"6v0i",
"6v0j",
"6vci",
"6xbd",
"6z5u",
"6zy2",
"6zy3",
"6zy4",
"6zy9",
"7ai2",
"7ai3",
"7cge",
"7cgn",
"7ch0",
"7ch8",
"7ch9",
"7cha",
"7d06",
"7d08",
"7d09"... | 45 | [
"PUB00009508",
"PUB00011684",
"PUB00015052",
"PUB00059298"
] | [
"8367727",
"12052567",
"14500535",
"19383799"
] | [
"Cloning of an M. tuberculosis DNA fragment associated with entry and survival inside cells.",
"Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT).",
"Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tubercul... | [
1993,
2002,
2003,
2009
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halogranum gelatinilyticum",
"Myoviridae sp. ctT1Q6",
"unclassified sequences"
] | [
68577,
1143,
1,
1,
458
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
2,
3,
2,
16
] | 4 | true | Domain | Mce/MlaD | Mce/MlaD | Mce/MlaD | 2 |
IPR003400 | 3,400 | Biopolymer transport protein ExbD/TolR | ExbD | Family | 48,825 | false | false | This group of proteins are membrane bound transport proteins essential for ferric ion uptake in bacteria [ ]. The family consists of ExbD, and TolR which are involved in TonB-dependent transport of various receptor bound substrates including colicins [ ]. | [
"GO:0022857",
"GO:0055085"
] | [
"transmembrane transporter activity",
"transmembrane transport"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF02472",
"PTHR30558"
] | [
"ExbD",
""
] | [
48821,
45154
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-9638334",
"R-HSA-9638482",
"R-HSA-9927020"
] | [
"REACTOME:R-HSA-9638334",
"REACTOME:R-HSA-9638482",
"REACTOME:R-HSA-9927020"
] | 3 | [
"2pfu",
"5by4",
"5sv1",
"6tyi",
"7ajq",
"8odt",
"8p9r",
"8pek",
"8vgc",
"8vgd",
"8vlw",
"9ddm",
"9ddn",
"9ddo",
"9ddp",
"9ddq",
"9k49",
"9kch"
] | 18 | [
"PUB00009506",
"PUB00009507"
] | [
"9371459",
"3294803"
] | [
"Unusual structure of the tonB-exb DNA region of Xanthomonas campestris pv. campestris: tonB, exbB, and exbD1 are essential for ferric iron uptake, but exbD2 is not.",
"Nucleotide sequence of a gene cluster involved in entry of E colicins and single-stranded DNA of infecting filamentous bacteriophages into Escher... | [
1997,
1987
] | 2 | [] | [
"IPR014168",
"IPR014170",
"IPR014171"
] | 0 | 3 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
45,
47828,
75,
3,
874
] | 5 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Biopolymer transport protein ExbD/TolR | Biopolymer transport protein ExbD/TolR | ExbD | 1 |
IPR003403 | 3,403 | Herpesvirus immediate early protein | IE68 | Family | 309 | false | false | This regulatory protein is expressed from an immediate early gene in the cell cycle of Herpesviridae. The protein is known by various names including IE-68, US1, ICP22 and IR4. It acts as a general transcriptional regulator of cellular and viral mRNAs, through modifications on the host RNA polymerase II which inhibit h... | [
"GO:0010468"
] | [
"regulation of gene expression"
] | [
"biological_process"
] | 1 | [
"PFAM"
] | [
"PF02479"
] | [
"Herpes_IE68"
] | [
309
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00095593",
"PUB00095594",
"PUB00095595"
] | [
"17344289",
"32699158",
"28611249"
] | [
"Herpes simplex virus immediate-early protein ICP22 triggers loss of serine 2-phosphorylated RNA polymerase II.",
"Herpes Simplex Virus Type 2 Inhibits Type I IFN Signaling Mediated by the Novel E3 Ubiquitin Protein Ligase Activity of Viral Protein ICP22.",
"A Herpesviral Immediate Early Protein Promotes Transc... | [
2007,
2020,
2017
] | 3 | [] | [] | 0 | 0 | null | [
"Alphaherpesvirinae",
"Opisthokonta",
"Pseudomethylobacillus aquaticus"
] | [
306,
2,
1
] | 3 | [] | [] | 0 | true | Family | Herpesvirus immediate early protein | Herpesvirus immediate early protein | IE68 | 8 |
IPR003404 | 3,404 | Envelope glycoprotein E, Fc-binding domain | Herpes_glycopE_Fc | Domain | 716 | false | false | This entry represents the Ig-like domain of Glycoprotein E (gE) from herpesvirus. This protein forms a complex with glycoprotein I (gI), functioning as an immunoglobulin G (IgG) Fc binding protein. gE is involved in virus spread but is not essential for propagation. This domain is identified as the Fc-binding domain [ ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02480"
] | [
"Herpes_gE"
] | [
716
] | 1 | [] | [] | [] | 0 | [
"2giy",
"2gj7",
"8v5p",
"8v5s",
"9jzq"
] | 5 | [
"PUB00009504",
"PUB00041071"
] | [
"10881679",
"16646632"
] | [
"Epitopes on glycoprotein E and on the glycoprotein E/glycoprotein I complex of bovine herpesvirus 1 are expressed by all of 222 isolates and 11 vaccine strains.",
"Crystal structure of the HSV-1 Fc receptor bound to Fc reveals a mechanism for antibody bipolar bridging."
] | [
2000,
2006
] | 2 | [] | [] | 0 | 0 | null | [
"Alphaherpesvirinae"
] | [
716
] | 1 | [] | [] | 0 | true | Domain | Envelope glycoprotein E, Fc-binding domain | Envelope glycoprotein E, Fc-binding domain | Herpes_glycopE_Fc | 4 |
IPR003406 | 3,406 | Glycosyl transferase, family 14 | Glyco_trans_14 | Family | 31,996 | false | false | The biosynthesis of disaccharides, oligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These enzymes catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. A classification of glycosyltransferas... | [
"GO:0016757",
"GO:0016020"
] | [
"glycosyltransferase activity",
"membrane"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF02485"
] | [
"Branch"
] | [
31996
] | 1 | [
"CAZY",
"EC",
"GP",
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"GT14",
"2.4.1",
"GenProp1545",
"GenProp1699",
"GenProp1712",
"R-BTA-913709",
"R-CEL-1971475",
"R-CFA-1971475",
"R-DME-1971475",
"R-DRE-913709",
"R-HSA-1971475",
"R-HSA-913709",
"R-MMU-1971475",
"R-MMU-913709",
"R-RNO-1971475",
"R-RNO-913709",
"R-SSC-913709"
] | [
"CAZY:GT14",
"EC:2.4.1",
"GP:GenProp1545",
"GP:GenProp1699",
"GP:GenProp1712",
"REACTOME:R-BTA-913709",
"REACTOME:R-CEL-1971475",
"REACTOME:R-CFA-1971475",
"REACTOME:R-DME-1971475",
"REACTOME:R-DRE-913709",
"REACTOME:R-HSA-1971475",
"REACTOME:R-HSA-913709",
"REACTOME:R-MMU-1971475",
"REACT... | 17 | [
"2gak",
"2gam",
"3otk",
"6ej7",
"6ej8",
"6ej9",
"6eja",
"6ejb",
"6ejc",
"6ejd",
"6eje",
"6foa"
] | 12 | [
"PUB00009409",
"PUB00009564",
"PUB00009565"
] | [
"9334165",
"8449405",
"9915862"
] | [
"A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities.",
"Expression of the developmental I antigen by a cloned human cDNA encoding a member of a beta-1,6-N-acetylglucosaminyltransferase gene family.",
"Molecular cloning and expression of a novel beta-1, ... | [
1997,
1993,
1999
] | 3 | [] | [
"IPR043538",
"IPR044174"
] | 0 | 2 | 0 | [
"Bacteria",
"Eukaryota",
"Methanococcus maripaludis",
"Viruses",
"metagenomes"
] | [
3370,
28508,
1,
36,
81
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
184,
29,
19,
1,
24,
24,
96,
23,
196
] | 9 | true | Family | Glycosyl transferase, family 14 | Glycosyl transferase, family 14 | Glyco_trans_14 | 2 |
IPR003407 | 3,407 | Merozoite antigen | Merozoite_Agen | Family | 1,420 | false | false | This family represents the immunodominant surface antigen of Theileria parasites including equi merozoite antigen-1 (EMA-1) and equi merozoite antigen-2 (EMA-2) [ ]. The protein shows variation at a putative glycosylation site, a potential mechanism for host immune response evasion [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02488"
] | [
"EMA"
] | [
1420
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00009502",
"PUB00009503"
] | [
"9497033",
"8538686"
] | [
"Genetic and biochemical analysis of erythrocyte-stage surface antigens belonging to a family of highly conserved proteins of Babesia equi and Theileria species.",
"Selection of diversity at putative glycosylation sites in the immunodominant merozoite/piroplasm surface antigen of Theileria parasites."
] | [
1997,
1995
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1420
] | 1 | [] | [] | 0 | true | Family | Merozoite antigen | Merozoite antigen | Merozoite_Agen | 7 |
IPR003409 | 3,409 | MORN repeat | MORN | Repeat | 47,207 | false | false | This entry represents MORN (Membrane Occupation and Recognition Nexus) repeat. This repeat was identified in multiple copies in several proteins including junctophilins [ ]. More recently it was found that MORN repeat proteins are quite ubiquitous and are present in both eukaryotes and prokaryotes. The number of MORN r... | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF02493",
"SM00698"
] | [
"MORN",
"MORN"
] | [
46856,
44251
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-8876198",
"R-DME-8876198",
"R-DME-9013149",
"R-HSA-3214841",
"R-HSA-8876198",
"R-HSA-9013149",
"R-MMU-3214841",
"R-MMU-8876198",
"R-MMU-9013149",
"R-RNO-8876198",
"R-RNO-9013149"
] | [
"REACTOME:R-BTA-8876198",
"REACTOME:R-DME-8876198",
"REACTOME:R-DME-9013149",
"REACTOME:R-HSA-3214841",
"REACTOME:R-HSA-8876198",
"REACTOME:R-HSA-9013149",
"REACTOME:R-MMU-3214841",
"REACTOME:R-MMU-8876198",
"REACTOME:R-MMU-9013149",
"REACTOME:R-RNO-8876198",
"REACTOME:R-RNO-9013149"
] | 11 | [
"1h3i",
"1mt6",
"1n6c",
"6jle",
"6t4d",
"6t4r",
"6t68",
"6t69",
"6t6q",
"7dmp",
"7jr9",
"7jrj",
"7jtk",
"7jts",
"7ju4",
"7n6g",
"7rw4",
"7rxe",
"7rxq",
"7sqc",
"7vcf",
"7xzi",
"7xzj",
"8glv",
"8j07",
"8wzb",
"8x2u",
"8z9y",
"9d2f",
"9e5c",
"9fqr",
"9ijj"... | 32 | [
"PUB00009501",
"PUB00103835",
"PUB00103867"
] | [
"10949023",
"33296386",
"31279628"
] | [
"Junctophilins: a novel family of junctional membrane complex proteins.",
"Structures of three MORN repeat proteins and a re-evaluation of the proposed lipid-binding properties of MORN repeats.",
"Structure of the MORN4/Myo3a Tail Complex Reveals MORN Repeats as Protein Binding Modules."
] | [
2000,
2020,
2019
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
7,
5489,
40825,
386,
500
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
66,
2,
66,
13,
73,
37,
42,
55,
92
] | 9 | true | Repeat | MORN repeat | MORN repeat | MORN | 3 |
IPR003410 | 3,410 | HYR domain | HYR_dom | Domain | 10,672 | false | false | The HYR (HYalin Repeat) domain is an extracellular domain of about 80-100 amino acids. It has been named after the hyalin protein, which is composed exclusively of repeats of this domain. The HYR domain is found in several eukaryotic proteins, either in multiple copies as in hyalin or in association with other domains ... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE"
] | [
"PF02494",
"PS50825"
] | [
"HYR",
"HYR"
] | [
9526,
10454
] | 2 | [
"PROSITEDOC"
] | [
"PDOC50825"
] | [
"PROSITEDOC:PDOC50825"
] | 1 | [] | 0 | [
"PUB00018110"
] | [
"10933504"
] | [
"HYR, an extracellular module involved in cellular adhesion and related to the immunoglobulin-like fold."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
69,
2712,
7841,
2,
48
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
9,
8,
8,
4,
9
] | 6 | true | Domain | HYR domain | HYR domain | HYR_dom | 9 |
IPR003411 | 3,411 | Triple gene block 3 | TGBp3 | Family | 1,283 | false | false | Members of this family include TGBp3 proteins found in many plant viruses. Triple gene block 3 proteins (TGBp3) are involved in virus momvement. TGBp3 is an integral ER membrane protein with a single transmembrane domain, and a C-terminal region exposed to the cytosol. TGBp3 is able to target TGBp2 to the cortical ER t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02495"
] | [
"TGBp3"
] | [
1283
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00091026"
] | [
"27863274"
] | [
"The cysteine residues at the C-terminal tail of Bamboo mosaic virus triple gene block protein 2 are critical for efficient plasmodesmata localization of protein 1 in the same block."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Riboviria",
"Solanum chacoense"
] | [
1282,
1
] | 2 | [] | [] | 0 | true | Family | Triple gene block 3 | Triple gene block 3 | TGBp3 | 8 |
IPR003412 | 3,412 | Arterivirus GP4 envelope glycoprotein | Arteri_GP4 | Family | 1,361 | false | false | Arteriviruses are small, enveloped, animal viruses with an icosahedral core containing a positive-sense RNA genome. The arteriviruses are highly species specific, but share many biological and molecular properties, including virion morphology, a unique set of structural proteins, genome organisation and replication str... | [
"GO:0019031"
] | [
"viral envelope"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF02497"
] | [
"Arteri_GP4"
] | [
1361
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00019166",
"PUB00076654"
] | [
"7948197",
"19939927"
] | [
"Cloning, expression, and sequence analysis of the ORF4 gene of the porcine reproductive and respiratory syndrome virus MN-1b.",
"The minor envelope glycoproteins GP2a and GP4 of porcine reproductive and respiratory syndrome virus interact with the receptor CD163."
] | [
1994,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Arteriviridae"
] | [
1361
] | 1 | [] | [] | 0 | true | Family | Arterivirus GP4 envelope glycoprotein | Arterivirus GP4 envelope glycoprotein | Arteri_GP4 | 5 |
IPR003415 | 3,415 | Telomere-binding protein, alpha subunit, Spirotrichea | Telomere-bd_alpha | Family | 15 | false | false | This entry represents the alpha subunit of the telomere-binding protein in ciliates. The telomer-binding protein forms a heterodimer in consisting of an alpha and a beta subunit. This complex may function as a protective cap for the single-stranded telomeric overhang, and may also participate in telomere length regulat... | [
"GO:0003677",
"GO:0016233",
"GO:0005634"
] | [
"DNA binding",
"telomere capping",
"nucleus"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PIRSF"
] | [
"PIRSF015848"
] | [
"TEBP_alpha"
] | [
15
] | 1 | [] | [] | [] | 0 | [
"1jb7",
"1kix",
"1otc",
"1pa6",
"1ph1",
"1ph2",
"1ph3",
"1ph4",
"1ph5",
"1ph6",
"1ph7",
"1ph8",
"1ph9",
"1phj",
"2i0q"
] | 15 | [
"PUB00026328"
] | [
"11428895"
] | [
"DNA G-quartets in a 1.86 A resolution structure of an Oxytricha nova telomeric protein-DNA complex."
] | [
2001
] | 1 | [
"IPR028389"
] | [] | 1 | 0 | 1 | [
"Spirotrichea"
] | [
15
] | 1 | [] | [] | 0 | true | Family | Telomere-binding protein, alpha subunit, Spirotrichea | Telomere-binding protein, alpha subunit, Spirotrichea | Telomere-bd_alpha | 9 |
IPR003416 | 3,416 | MgtC/SapB/SrpB/YhiD family | MgtC/SapB/SrpB/YhiD_fam | Family | 18,741 | false | false | This entry includes a group of transmembrane proteins, including MgtC, SapB, SrpB and YhiD from bacteria. | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PRINTS",
"PANTHER"
] | [
"PR01837",
"PTHR33778"
] | [
"MGTCSAPBPROT",
""
] | [
18551,
18207
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00062338",
"PUB00062339",
"PUB00062341",
"PUB00070393"
] | [
"9673265",
"16855249",
"17176255",
"19798051"
] | [
"Magnesium and the role of MgtC in growth of Salmonella typhimurium.",
"The MgtC virulence factor of Salmonella enterica serovar Typhimurium activates Na(+),K(+)-ATPase.",
"Dual role of the MgtC virulence factor in host and non-host environments.",
"Mg(2+)-dependent gating of bacterial MgtE channel underlies ... | [
1998,
2006,
2007,
2009
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacillus phage G",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
366,
1,
17927,
295,
152
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | MgtC/SapB/SrpB/YhiD family | MgtC/SapB/SrpB/YhiD family | MgtC/SapB/SrpB/YhiD_fam | 7 |
IPR003417 | 3,417 | Core-binding factor, beta subunit | CBF_beta | Family | 2,226 | false | false | Core binding factor (CBF) is a heterodimeric transcription factor essential for genetic regulation of hematopoiesis and osteogenesis. The beta subunit binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including Murine leukemia virus, Polyomavirus enhancer, T-cell receptor enhancers etc. Th... | [
"GO:0003713",
"GO:0005634"
] | [
"transcription coactivator activity",
"nucleus"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF02312",
"PTHR10276"
] | [
"CBF_beta",
""
] | [
2223,
2102
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-8877330",
"R-CEL-8878166",
"R-CEL-8934593",
"R-CEL-8936459",
"R-CEL-8939236",
"R-CEL-8939243",
"R-CEL-8939245",
"R-CEL-8939246",
"R-CEL-8939247",
"R-CEL-8941326",
"R-CEL-8941858",
"R-CEL-8951936",
"R-DME-8877330",
"R-DME-8878166",
"R-DME-8931987",
"R-DME-8934593",
"R-DME-89364... | [
"REACTOME:R-CEL-8877330",
"REACTOME:R-CEL-8878166",
"REACTOME:R-CEL-8934593",
"REACTOME:R-CEL-8936459",
"REACTOME:R-CEL-8939236",
"REACTOME:R-CEL-8939243",
"REACTOME:R-CEL-8939245",
"REACTOME:R-CEL-8939246",
"REACTOME:R-CEL-8939247",
"REACTOME:R-CEL-8941326",
"REACTOME:R-CEL-8941858",
"REACTOM... | 65 | [
"1cl3",
"1e50",
"1h9d",
"1ilf",
"1io4",
"2jhb",
"3wts",
"3wtt",
"3wtu",
"3wtv",
"3wtw",
"3wtx",
"3wty",
"4n9f",
"6nil",
"6p59",
"6vgd",
"6vge",
"6vgg",
"8cx0",
"8cx1",
"8cx2",
"8e40",
"8fvi",
"8fvj",
"8h0i",
"8j62",
"8szk"
] | 28 | [
"PUB00009499"
] | [
"10404215"
] | [
"Molecular insights into PEBP2/CBF beta-SMMHC associated acute leukemia revealed from the structure of PEBP2/CBF beta."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Metazoa"
] | [
36,
2190
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
8,
6,
7,
2,
4
] | 6 | true | Family | Core-binding factor, beta subunit | Core-binding factor, beta subunit | CBF_beta | 4 |
IPR003418 | 3,418 | Fumarate reductase, subunit D | Fumarate_red_D | Family | 2,101 | false | false | Fumarate reductase is a membrane-bound flavoenzyme consisting of four subunits [ , ]. Subunits A and B comprise the membrane-extrinsic catalytic domain and C and D link the catalytic centres to the electron-transport chain. This family consists of the 13kDa hydrophobic subunit D. This component may be required to ancho... | [
"GO:0006106",
"GO:0016020"
] | [
"fumarate metabolic process",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"HAMAP",
"NCBIFAM",
"PFAM",
"PIRSF",
"CDD"
] | [
"MF_00709",
"NF003977",
"PF02313",
"PIRSF000179",
"cd00547"
] | [
"Fumarate_red_D",
"PRK05470.1-1",
"Fumarate_red_D",
"FrdD",
"QFR_TypeD_subunitD"
] | [
1705,
2053,
2101,
1651,
1674
] | 5 | [
"GP",
"GP",
"GP",
"GP",
"GP",
"GP"
] | [
"GenProp0756",
"GenProp1143",
"GenProp1267",
"GenProp1391",
"GenProp1537",
"GenProp1672"
] | [
"GP:GenProp0756",
"GP:GenProp1143",
"GP:GenProp1267",
"GP:GenProp1391",
"GP:GenProp1537",
"GP:GenProp1672"
] | 6 | [
"1kf6",
"1kfy",
"1l0v",
"2b76",
"3cir",
"3p4p",
"3p4q",
"3p4r",
"3p4s",
"4kx6",
"5vpn",
"6awf"
] | 12 | [
"PUB00020385",
"PUB00079621"
] | [
"10373108",
"10981634"
] | [
"Structure of the Escherichia coli fumarate reductase respiratory complex.",
"Analyzing your complexes: structure of the quinol-fumarate reductase respiratory complex."
] | [
1999,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Capitella teleta",
"metagenomes"
] | [
2072,
1,
28
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Fumarate reductase, subunit D | Fumarate reductase, subunit D | Fumarate_red_D | 5 |
IPR003420 | 3,420 | Methanol dehydrogenase, beta subunit | Meth_DH_bsu | Family | 271 | false | false | Methanol dehydrogenase (MDH) ( ), found in Gram-negative bacteria, is a pyrroloquinoline quinone (PQQ)-containing enzyme which oxidises methanol to formaldehyde. It is located in the periplasmic space and passes electrons derived from the oxidation of methanol to the soluble cytochrome cL [ ]. The enzyme is a tetramer ... | [
"GO:0004022",
"GO:0015946"
] | [
"alcohol dehydrogenase (NAD+) activity",
"methanol oxidation"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PIRSF"
] | [
"PF02315",
"PIRSF029163"
] | [
"MDH",
"Meth_DH_beta"
] | [
271,
246
] | 2 | [
"EC",
"METACYC"
] | [
"1.1.2.7",
"PWY-6966"
] | [
"EC:1.1.2.7",
"METACYC:PWY-6966"
] | 2 | [
"1g72",
"1h4i",
"1h4j",
"1lrw",
"1w6s",
"2ad6",
"2ad7",
"2ad8",
"2d0v",
"4aah",
"4tqo",
"5xm3",
"7cdl",
"7ce5",
"7ce9",
"7ced",
"7cfx"
] | 17 | [
"PUB00025506",
"PUB00035561"
] | [
"11502173",
"15234264"
] | [
"Site-directed mutagenesis and X-ray crystallography of the PQQ-containing quinoprotein methanol dehydrogenase and its electron acceptor, cytochrome c(L).",
"The quinoprotein dehydrogenases for methanol and glucose."
] | [
2001,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"marine sediment metagenome"
] | [
270,
1
] | 2 | [] | [] | 0 | true | Family | Methanol dehydrogenase, beta subunit | Methanol dehydrogenase, beta subunit | Meth_DH_bsu | 9 |
IPR003421 | 3,421 | Opine dehydrogenase | Opine_DH | Domain | 3,387 | false | false | This group of enzymes act on the CH-NH substrate bond using NAD(+) or NADP(+) as an acceptor. This domain is found primarily in octopine dehydrogenase ( ), nopaline dehydrogenase ( ), and lysopine dehydrogenase ( ). NADPH is the preferred cofactor, but NADH is also used. Octopine dehydrogenase is involved in the reduct... | [
"GO:0016491"
] | [
"oxidoreductase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF02317"
] | [
"Octopine_DH"
] | [
3387
] | 1 | [
"EC"
] | [
"1.5.1"
] | [
"EC:1.5.1"
] | 1 | [
"1bg6",
"3c7a",
"3c7c",
"3c7d",
"3iqd"
] | 5 | [
"PUB00016267",
"PUB00017337"
] | [
"9665174",
"10786948"
] | [
"Crystal structure and active site location of N-(1-D-carboxylethyl)-L-norvaline dehydrogenase.",
"Light-limitation on predator-prey interactions: consequences for metabolism and locomotion of deep-sea cephalopods."
] | [
1998,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
14,
2333,
971,
69
] | 4 | [] | [] | 0 | true | Domain | Opine dehydrogenase | Opine dehydrogenase | Opine_DH | 2 |
IPR003422 | 3,422 | Cytochrome b-c1 complex, subunit 6 | Cyt_b-c1_6 | Family | 4,175 | false | false | The ubiquinol-cytochrome C reductase complex (cytochrome bc1 complex) is a respiratory multienzyme complex [ ]. The bc1 complex contains 11 subunits; 3 respiratory subunits (cytochrome B, cytochrome C1, Rieske protein), 2 core proteins and 6 low molecular weight proteins. This family represents the 'hinge' protein of t... | [
"GO:0006122"
] | [
"mitochondrial electron transport, ubiquinol to cytochrome c"
] | [
"biological_process"
] | 1 | [
"PIRSF",
"PANTHER"
] | [
"PIRSF000019",
"PTHR15336"
] | [
"Bc1_11K",
""
] | [
1447,
4173
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-611105",
"R-BTA-9865881",
"R-DDI-611105",
"R-HSA-611105",
"R-HSA-9865881",
"R-MMU-611105",
"R-MMU-9865881",
"R-RNO-611105",
"R-RNO-9865881",
"R-SPO-611105"
] | [
"REACTOME:R-BTA-611105",
"REACTOME:R-BTA-9865881",
"REACTOME:R-DDI-611105",
"REACTOME:R-HSA-611105",
"REACTOME:R-HSA-9865881",
"REACTOME:R-MMU-611105",
"REACTOME:R-MMU-9865881",
"REACTOME:R-RNO-611105",
"REACTOME:R-RNO-9865881",
"REACTOME:R-SPO-611105"
] | 10 | [
"1bcc",
"1be3",
"1bgy",
"1ezv",
"1kb9",
"1kyo",
"1l0l",
"1l0n",
"1ntk",
"1ntm",
"1ntz",
"1nu1",
"1p84",
"1pp9",
"1ppj",
"1qcr",
"1sqb",
"1sqp",
"1sqq",
"1sqv",
"1sqx",
"2a06",
"2bcc",
"2fyu",
"2ibz",
"2ybb",
"3bcc",
"3cwb",
"3h1h",
"3h1i",
"3h1j",
"3h1k"... | 149 | [
"PUB00006415"
] | [
"9651245"
] | [
"Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4175
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (stra... | [
7,
1,
1,
3,
3,
2,
1,
8,
4,
1,
15
] | 11 | true | Family | Cytochrome b-c1 complex, subunit 6 | Cytochrome b-c1 complex, subunit 6 | Cyt_b-c1_6 | 2 |
IPR003423 | 3,423 | Outer membrane efflux protein | OMP_efflux | Family | 122,728 | false | false | The OEP family (Outer membrane efflux protein) form trimeric channels that allow export of a variety of substrates in Gram-negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all β sheet barrel that spans the outer membrane, and a long all helical ... | [
"GO:0015562",
"GO:0055085"
] | [
"efflux transmembrane transporter activity",
"transmembrane transport"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF02321"
] | [
"OEP"
] | [
122728
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-9638334",
"R-HSA-9760173",
"R-HSA-9913143"
] | [
"REACTOME:R-HSA-9638334",
"REACTOME:R-HSA-9760173",
"REACTOME:R-HSA-9913143"
] | 3 | [
"1ek9",
"1tqq",
"1wp1",
"1yc9",
"2vdd",
"2vde",
"2wmz",
"2xmn",
"3d5k",
"3pik",
"4k34",
"4k7k",
"4k7r",
"4mt0",
"4mt4",
"4y1k",
"5azo",
"5azp",
"5azs",
"5bun",
"5iuy",
"5ng5",
"5nik",
"5nil",
"5nsw",
"5o66",
"5v5s",
"6iok",
"6iol",
"6ta5",
"6ta6",
"6u94"... | 46 | [] | [] | [] | [] | 0 | [] | [
"IPR010131",
"IPR051906"
] | 0 | 2 | 0 | [
"Bacteria",
"Eukaryota",
"Plasmid pMCBF1",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
121009,
195,
1,
3,
1520
] | 5 | [
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica"
] | [
4,
1
] | 2 | true | Family | Outer membrane efflux protein | Outer membrane efflux protein | OMP_efflux | 6 |
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