LiteFold/InterPro · Datasets at Hugging Face

IPR003424

3,424

Egg-laying hormone/atrial gland peptide

ELH

Family

57

false

This family consists of egg-laying hormone (ELH) precursor and atrial gland peptides from the little (Aplysia parvula) and california (Aplysia californica) sea hares. The family also includes ovulation prohormone precursor from the great pond snail (Lymnaea stagnalis). This family thus represents a conserved gastropoda...

[ "GO:0005179", "GO:0007275", "GO:0005576" ]

[ "hormone activity", "multicellular organism development", "extracellular region" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF02323" ]

[ "ELH" ]

[ 57 ]

1

[]

0

[]

0

[ "PUB00009497", "PUB00009498" ]

[ "9520477", "10518477" ]

[ "Proteolytic processing of the Aplysia egg-laying hormone prohormone.", "Egg-laying hormone peptides in the aplysiidae family." ]

[ 1998, 1999 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses" ]

[ 2, 53, 2 ]

3

[]

0

true

Family

Egg-laying hormone/atrial gland peptide

ELH

6

IPR003425

3,425

CCB3/YggT

Family

21,874

false

This family includes YlmG from bacteria, CCB3 and YlmG homologue proteins (YLMG1-1, YLMG1-2, YLMG2) from Arabidopsis [ ]. This family also includes the uncharacterised protein YggT, which has been reported to be required for growth of E.coli mutant cells lacking the major potassium uptake systems [ ]. YlmG might be inv...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF02325", "PTHR33219" ]

[ "CCB3_YggT", "" ]

[ 21834, 12498 ]

2

[]

0

[ "7vcf", "7xzi" ]

2

[ "PUB00075312", "PUB00075315", "PUB00097642", "PUB00161041" ]

[ "17535914", "18593701", "20359373", "19966467" ]

[ "A specific c-type cytochrome maturation system is required for oxygenic photosynthesis.", "A novel pathway of cytochrome c biogenesis is involved in the assembly of the cytochrome b6f complex in arabidopsis chloroplasts.", "The YlmG protein has a conserved function related to the distribution of nucleoids in c...

[ 2007, 2008, 2010, 2009 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 18924, 2541, 409 ]

3

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 17, 1, 9, 9 ]

4

true

Family

CCB3/YggT

3

IPR003426

3,426

Bacteriochlorophyll A protein

BChl_A

Family

104

false

Bacteriochlorophyll A (or FMO) protein is involved in the energy transfer system of photosynthetic bacteria, such as Green Sulphur Bacteria. Bacteriochlorophyll A acts as a light-harvesting complex that directs light energy from the chlorosomes attached to the cell membrane to the reaction centre [ ]. The protein forms...

[ "GO:0015979" ]

[ "photosynthesis" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF02327" ]

[ "BChl_A" ]

[ 104 ]

1

[]

0

[ "3bsd", "3eni", "3eoj", "3vdi", "4bcl", "5h8z", "6m32", "6mez", "7uea", "7ueb", "7z6q", "8gwa" ]

12

[ "PUB00027705" ]

[ "16245093" ]

[ "The structure of the FMO protein from Chlorobium tepidum at 2.2 A resolution." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria" ]

[ 104 ]

1

[]

0

true

Family

Bacteriochlorophyll A protein

BChl_A

4

IPR003427

3,427

Histidine decarboxylase proenzyme

His_de-COase_proenz

Family

199

false

Histidine decarboxylase ( ) catalyses the formation of histamine from histidine [ ]. It requires a pyruvoyl group for its activity. Cleavage of the proenzyme PI chain yields two subunits, alpha and beta, which arrange as a hexamer (alpha beta) 6 by nonhydrolytic self-catalysis. In Lactobacillus cells, pyruvoyl-dependen...

[ "GO:0004398", "GO:0006547" ]

[ "histidine decarboxylase activity", "L-histidine metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PIRSF", "SFLD", "NCBIFAM" ]

[ "PF02329", "PIRSF001341", "SFLDF00466", "TIGR00541" ]

[ "HDC", "His_decarboxylas", "Pyruvoyl-dependent_histidine_d", "hisDCase_pyru" ]

[ 199, 153, 108, 109 ]

4

[ "EC", "GP", "METACYC" ]

[ "4.1.1.22", "GenProp0872", "PWY-6173" ]

[ "EC:4.1.1.22", "GP:GenProp0872", "METACYC:PWY-6173" ]

3

[ "1hq6", "1ibt", "1ibu", "1ibv", "1ibw", "1pya" ]

6

[ "PUB00025755", "PUB00035745", "PUB00081909", "PUB00081910" ]

[ "11243783", "2197977", "2745463", "8490030" ]

[ "pH-induced structural changes regulate histidine decarboxylase activity in Lactobacillus 30a.", "Pyruvoyl-dependent enzymes.", "Pyruvoyl-dependent histidine decarboxylase. Active site structure and mechanistic analysis.", "Site-directed alteration of three active-site residues of a pyruvoyl-dependent histidi...

[ 2001, 1990, 1989, 1993 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Methanosarcina barkeri", "marine sediment metagenome" ]

[ 192, 3, 2, 2 ]

4

[]

0

true

Family

Histidine decarboxylase proenzyme

His_de-COase_proenz

7

IPR003428

3,428

Mitochondrial glycoprotein

MAM33

Family

7,964

false

This mitochondrial matrix protein family contains members of the MAM33 family (also known as Complement component 1 Q subcomponent-binding protein in human) which bind to the globular 'heads' of C1Q.b [ ]. In vertebrates, these proteins are involved in inflammation and infection processes, ribosome biogenesis, protein ...

[ "GO:0005759" ]

[ "mitochondrial matrix" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF02330", "PTHR10826" ]

[ "MAM33", "" ]

[ 7853, 7128 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-140837", "R-BTA-8980692", "R-BTA-9013106", "R-CEL-8980692", "R-HSA-111471", "R-HSA-140837", "R-HSA-8980692", "R-HSA-9013106", "R-HSA-9645722", "R-MMU-140837", "R-MMU-8980692", "R-MMU-9013106", "R-RNO-140837", "R-RNO-8980692", "R-SCE-8980692", "R-SCE-9013106", "R-SPO-8980692", ...

[ "REACTOME:R-BTA-140837", "REACTOME:R-BTA-8980692", "REACTOME:R-BTA-9013106", "REACTOME:R-CEL-8980692", "REACTOME:R-HSA-111471", "REACTOME:R-HSA-140837", "REACTOME:R-HSA-8980692", "REACTOME:R-HSA-9013106", "REACTOME:R-HSA-9645722", "REACTOME:R-MMU-140837", "REACTOME:R-MMU-8980692", "REACTOME:R-...

18

[ "1p32", "1yqf", "3jv1", "3qv0", "3rpx", "6sg9", "6sgb", "6szw", "7pkq", "7te3", "9hny" ]

11

[ "PUB00019832", "PUB00019833", "PUB00102861", "PUB00155087", "PUB00155088", "PUB00155089" ]

[ "10097078", "9559539", "18676636", "22700724", "28942965", "8195709" ]

[ "Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein.", "Mam33p, an oligomeric, acidic protein in the mitochondrial matrix of Saccharomyces cerevisiae is related to the human complement receptor gC1q-R.", "Human p32 is a novel FOXC1-interacting protein that regulates FOXC1 tran...

[ 1999, 1998, 2008, 2012, 2017, 1994 ]

6

[]

0

null

[ "Actinokineospora xionganensis", "Eukaryota" ]

[ 1, 7963 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 46, 2, 4, 3, 4, 2, 1, 24, 4, 1, 2, 31 ]

12

true

Family

Mitochondrial glycoprotein

MAM33

8

IPR003429

3,429

Baculovirus p35, apoptosis preventing protein

Baculovirus_p35

Family

42

false

The anti-apoptotic protein p35 from baculovirus is thought to prevent the suicidal response of infected insect cells by inhibiting caspases. Ectopic expression of p35 in a number of transgenic animals or cell lines is also anti-apoptotic, giving rise to the hypothesis that the protein is a general inhibitor of caspases...

[ "GO:0043027", "GO:0043066" ]

[ "cysteine-type endopeptidase inhibitor activity involved in apoptotic process", "negative regulation of apoptotic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF02331" ]

[ "P35" ]

[ 42 ]

1

[]

0

[ "1i3p", "1i3s", "1i4e", "1p35", "2fun" ]

5

[ "PUB00014958", "PUB00014959" ]

[ "9692966", "14980489" ]

[ "Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex.", "The role of baculovirus apoptotic suppressors in AcMNPV-mediated translation arrest in Ld652Y cells." ]

[ 1998, 2004 ]

2

[]

0

null

[ "Bilateria", "Viruses" ]

[ 2, 40 ]

2

[]

0

true

Family

Baculovirus p35, apoptosis preventing protein

Baculovirus_p35

3

IPR003430

3,430

Propane/methane/phenol/toluene hydroxylase

Phenol_Hydrox

Family

4,054

false

This entry includes several components of multicomponent enzyme systems predominantly found in Proteobacteria and Actinobacteria. Propane 2-monooxygenase multicomponent enzyme system is involved in the degradation of propane via the O2-dependent hydroxylation of propane [ ]. Propane 2-monooxygenase, hydroxylase compone...

[]

0

[ "PFAM" ]

[ "PF02332" ]

[ "Phenol_Hydrox" ]

[ 4054 ]

1

[ "EC" ]

[ "1.14.13" ]

[ "EC:1.14.13" ]

1

[ "1fyz", "1fz0", "1fz1", "1fz2", "1fz3", "1fz4", "1fz5", "1fz6", "1fz7", "1fz8", "1fz9", "1fzh", "1fzi", "1mhy", "1mhz", "1mmo", "1mty", "1t0q", "1t0r", "1t0s", "1xmf", "1xmg", "1xmh", "1xu3", "1xu5", "1xvb", "1xvc", "1xvd", "1xve", "1xvf", "1xvg", "2inc"...

90

[ "PUB00002124", "PUB00012297", "PUB00088050", "PUB00088161", "PUB00100233", "PUB00100255" ]

[ "2254258", "1885512", "9312093", "21183637", "2254259", "12186554" ]

[ "Complete nucleotide sequence and polypeptide analysis of multicomponent phenol hydroxylase from Pseudomonas sp. strain CF600.", "Cloning and characterization of a Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.", "Alkene monooxygenase from Xanthobacter strain Py2. Purification and char...

[ 1990, 1991, 1997, 2011, 1990, 2002 ]

6

[]

[ "IPR012078" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 38, 3893, 7, 116 ]

4

[]

0

true

Family

Propane/methane/phenol/toluene hydroxylase

Phenol_Hydrox

1

IPR003431

3,431

3 pythase, beta-propeller

B-propeller_Phytase

Domain

4,239

false

Phytase ( ) (phytate 3-phosphatase) is a secreted enzyme which hydrolyses phytate to release inorganic phosphate. According to their three-dimensional structures and catalytic mechanisms, phytases are classified into different groups, one of them the β-propeller phytases [ ]. The β-propeller phytase domain is made of s...

[ "GO:0016158" ]

[ "inositol hexakisphosphate 3-phosphatase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PROFILE" ]

[ "PF02333", "PS51662" ]

[ "Phytase", "BP_PHYTASE" ]

[ 3930, 4233 ]

2

[ "EC", "METACYC" ]

[ "3.1.3.8", "PWY-4702" ]

[ "EC:3.1.3.8", "METACYC:PWY-4702" ]

2

[ "1cvm", "1h6l", "1poo", "1qlg", "2poo", "3amr", "3ams" ]

7

[ "PUB00009496", "PUB00036846" ]

[ "10655618", "11566134" ]

[ "Crystal structures of a novel, thermostable phytase in partially and fully calcium-loaded states.", "Enzyme mechanism and catalytic property of beta propeller phytase." ]

[ 2000, 2001 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Natrinema altunense", "metagenomes" ]

[ 3753, 462, 2, 22 ]

4

[]

0

true

Domain

3 pythase, beta-propeller

B-propeller_Phytase

6

IPR003432

3,432

Replication terminator protein

RTP

Family

385

false

The bacterial replication terminator protein (RTP) plays a role in the termination of DNA replication by impeding replication fork movement. Two RTP dimers bind to the two inverted repeat regions at the termination site.

[ "GO:0003677", "GO:0006274" ]

[ "DNA binding", "DNA replication termination" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PIRSF" ]

[ "PF02334", "PIRSF021424" ]

[ "RTP", "RTP" ]

[ 385, 318 ]

2

[]

0

[ "1bm9", "1f4k", "1j0r", "2dpd", "2dpu", "2dqr", "2efw" ]

7

[]

0

[]

0

null

[ "Bacillales", "Eukaryota", "Jenstvirus jenst" ]

[ 381, 2, 2 ]

3

[]

0

true

Family

Replication terminator protein

RTP

1

IPR003434

3,434

Arterivirus GP2a envelope protein

Arteri_GP2a

Family

1,408

false

This family consists of a envelope glycoprotein GP2a or ORF2 in Porcine reproductive and respiratory syndrome virus (PRRSV) [ ]. Also in the family is a minor structural protein from lactate dehydrogenase-elevating virus.

[]

0

[ "PFAM" ]

[ "PF02340" ]

[ "PRRSV_Env" ]

[ 1408 ]

1

[]

0

[]

0

[ "PUB00076654" ]

[ "19939927" ]

[ "The minor envelope glycoproteins GP2a and GP4 of porcine reproductive and respiratory syndrome virus interact with the receptor CD163." ]

[ 2010 ]

1

[]

0

null

[ "Arteriviridae" ]

[ 1408 ]

1

[]

0

true

Family

Arterivirus GP2a envelope protein

Arteri_GP2a

1

IPR003435

3,435

Chaperonin-like RbcX

Chaperonin_RcbX

Family

4,023

false

The RbcX protein has been identified as having a chaperonin-like function as it assists in the correct assembly of RbcL and RbcS subunits during RuBisCO biogenesis and it is also required to reach its maximal activity [ , ]. The rbcX gene is juxtaposed to and cotranscribed with rbcL and rbcS encoding RubisCO in Anabaen...

[ "GO:0044183", "GO:0110102" ]

[ "protein folding chaperone", "ribulose bisphosphate carboxylase complex assembly" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER" ]

[ "PF02341", "PTHR33791" ]

[ "RbcX", "" ]

[ 3952, 3802 ]

2

[]

0

[ "2pei", "2pej", "2pek", "2pem", "2pen", "2peo", "2peq", "2py8", "2wvw", "2z44", "2z45", "2z46", "3hyb", "3q20", "3rg6", "4gr2", "4gr6", "5bs1", "5bs2", "7xsd" ]

20

[ "PUB00009493", "PUB00009494", "PUB00095596", "PUB00095597" ]

[ "9642201", "9171433", "21922322", "21821880" ]

[ "Evolution of cyanobacteria by exchange of genetic material among phyletically related strains.", "Maximum activity of recombinant ribulose 1,5-bisphosphate carboxylase/oxygenase of Anabaena sp. strain CA requires the product of the rbcX gene.", "Initial characteristics of RbcX proteins from Arabidopsis thalian...

[ 1998, 1997, 2011, 2011 ]

4

[]

[ "IPR046381" ]

0

1

0

[ "Bacteria", "Eukaryota", "unclassified Prasinovirus" ]

[ 2437, 1584, 2 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 8, 13 ]

3

true

Family

Chaperonin-like RbcX

Chaperonin_RcbX

7

IPR003436

3,436

Chordopoxvirus fusion protein/multifunctional envelope protein A27

Chordopox_Fusion/A27

Family

398

false

This is a family of viral fusion proteins from the Chordopoxvirinae. A 14kDa Vaccinia virus protein has been demonstrated to function as a viral fusion protein mediating cell fusion at endosmomal (low) pH [ ]. The protein, found in the envelope fraction of the virions, is required for fusing the outermost of the two go...

[ "GO:0019064", "GO:0019031" ]

[ "fusion of virus membrane with host plasma membrane", "viral envelope" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PRINTS" ]

[ "PF02346", "PR01847" ]

[ "Vac_Fusion", "VIRALFUSION" ]

[ 398, 184 ]

2

[]

0

[ "3vop" ]

1

[ "PUB00009492", "PUB00075694" ]

[ "2389560", "23990784" ]

[ "Vaccinia virus induces cell fusion at acid pH and this activity is mediated by the N-terminus of the 14-kDa virus envelope protein.", "Crystal structure of vaccinia viral A27 protein reveals a novel structure critical for its function and complex formation with A26 protein." ]

[ 1990, 2013 ]

2

[]

0

null

[ "Poxviridae" ]

[ 398 ]

1

[]

0

true

Family

Chordopoxvirus fusion protein/multifunctional envelope protein A27

Chordopox_Fusion/A27

2

IPR003437

3,437

Glycine dehydrogenase (decarboxylating)

GcvP

Family

19,894

false

The P protein, also known as Glycine dehydrogenase (decarboxylating), is part of the glycine decarboxylase multienzyme complex (GDC), also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T [ ]. The P protein ( ) binds the alpha-amino group of glycine through its pyrid...

[ "GO:0004375", "GO:0006544" ]

[ "glycine dehydrogenase (decarboxylating) activity", "glycine metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_00711", "TIGR00461" ]

[ "GcvP", "gcvP" ]

[ 16501, 19855 ]

2

[ "EC", "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.4.4.2", "GenProp1275", "GenProp1356", "R-DDI-6783984", "R-HSA-6783984", "R-MMU-6783984", "R-SCE-6783984", "R-SPO-6783984" ]

[ "EC:1.4.4.2", "GP:GenProp1275", "GP:GenProp1356", "REACTOME:R-DDI-6783984", "REACTOME:R-HSA-6783984", "REACTOME:R-MMU-6783984", "REACTOME:R-SCE-6783984", "REACTOME:R-SPO-6783984" ]

8

[ "4lgl", "4lhc", "4lhd", "6i33", "6i34", "6i35" ]

6

[ "PUB00009491", "PUB00038183" ]

[ "8181752", "15791207" ]

[ "Characterization of the Escherichia coli gcv operon.", "Structure of P-protein of the glycine cleavage system: implications for nonketotic hyperglycinemia." ]

[ 1994, 2005 ]

2

[ "IPR020581" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Viruses", "unclassified Candidatus Thermoprofundales", "unclassified sequences" ]

[ 15392, 4190, 5, 6, 301 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 10, 2, 1, 1, 1, 2, 2, 1, 6, 2, 1, 1, 3 ]

13

true

Family

Glycine dehydrogenase (decarboxylating)

GcvP

4

IPR003438

3,438

Glial cell line-derived neurotrophic factor receptor

GDNF_rcpt

Family

6,776

false

Glial cell line-derived neurotrophic factor (GDNF) and its related factors neurturin (NTN), artemin (ART) and persephin (PSP), are members of the GDNF family of neurotrophic factors. They form a sub-group in the transforming growth factor-beta (TGF-beta) superfamily. These factors are involved in the promotion of neuro...

[ "GO:0038023" ]

[ "signaling receptor activity" ]

[ "molecular_function" ]

1

[ "PRINTS", "PANTHER" ]

[ "PR01316", "PTHR10269" ]

[ "GDNFRECEPTOR", "" ]

[ 4723, 6766 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-GGA-5673001", "R-GGA-8853659", "R-HSA-419037", "R-HSA-5673001", "R-HSA-8853659", "R-HSA-9830674", "R-MMU-5673001", "R-MMU-8853659", "R-RNO-5673001", "R-RNO-8853659" ]

[ "REACTOME:R-GGA-5673001", "REACTOME:R-GGA-8853659", "REACTOME:R-HSA-419037", "REACTOME:R-HSA-5673001", "REACTOME:R-HSA-8853659", "REACTOME:R-HSA-9830674", "REACTOME:R-MMU-5673001", "REACTOME:R-MMU-8853659", "REACTOME:R-RNO-5673001", "REACTOME:R-RNO-8853659" ]

10

[ "1q8d", "2gh0", "2v5e", "3fub", "4ux8", "5mr4", "5mr5", "5vz4", "6gl7", "6q2j", "6q2n", "6q2o", "6q2r", "6q2s", "6wmw", "7ab8", "7aml", "8os6", "9hyt" ]

19

[ "PUB00009432", "PUB00009433", "PUB00009434", "PUB00009435" ]

[ "10356294", "9192684", "9576965", "9647690" ]

[ "GDNF family neurotrophic factor signaling: four masters, one servant?", "Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons.", "GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family.", "GFRalpha-4, a new ...

[ 1999, 1997, 1998, 1998 ]

4

[]

[ "IPR003505", "IPR017372" ]

0

2

0

[ "Bilateria" ]

[ 6776 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 13, 10, 16, 17, 32 ]

6

true

Family

Glial cell line-derived neurotrophic factor receptor

GDNF_rcpt

1

IPR003439

3,439

ABC transporter-like, ATP-binding domain

ABC_transporter-like_ATP-bd

Domain

2,315,653

false

This entry represents a conserved region found in a group of related ATP-binding proteins and is associated with ATP-binding [ , , , , ]. The proteins belonging to this group also contain one or two copies of the 'A' consensus sequence [ ] or the 'P-loop' sequence motif [ ]. ABC transporters belong to the ATP-Binding C...

[ "GO:0005524", "GO:0016887" ]

[ "ATP binding", "ATP hydrolysis activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM", "PROFILE" ]

[ "PF00005", "PS50893" ]

[ "ABC_tran", "ABC_TRANSPORTER_2" ]

[ 2282406, 2251081 ]

2

[ "GP", "GP", "GP", "GP", "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "R...

[ "GenProp0457", "GenProp0828", "GenProp1398", "GenProp1756", "PDOC00185", "R-BTA-1660661", "R-BTA-189483", "R-BTA-2142691", "R-BTA-2453902", "R-BTA-382556", "R-BTA-9707564", "R-BTA-9753281", "R-BTA-9758890", "R-CEL-1369007", "R-CEL-159418", "R-CEL-189483", "R-CEL-2142845", "R-CEL-38...

[ "GP:GenProp0457", "GP:GenProp0828", "GP:GenProp1398", "GP:GenProp1756", "PROSITEDOC:PDOC00185", "REACTOME:R-BTA-1660661", "REACTOME:R-BTA-189483", "REACTOME:R-BTA-2142691", "REACTOME:R-BTA-2453902", "REACTOME:R-BTA-382556", "REACTOME:R-BTA-9707564", "REACTOME:R-BTA-9753281", "REACTOME:R-BTA-...

303

[ "1b0u", "1f3o", "1g29", "1g6h", "1g9x", "1gaj", "1ji0", "1jj7", "1l2t", "1l7v", "1mt0", "1mv5", "1oxs", "1oxt", "1oxu", "1oxv", "1oxx", "1q12", "1q1b", "1q1e", "1q3h", "1r0w", "1r0x", "1r0y", "1r0z", "1r10", "1sgw", "1v43", "1vci", "1vpl", "1xef", "1xf9"...

1,165

[ "PUB00000705", "PUB00001131", "PUB00002368", "PUB00003805", "PUB00003995", "PUB00003996", "PUB00004290", "PUB00005361", "PUB00014769", "PUB00017894", "PUB00017895", "PUB00017896", "PUB00017897", "PUB00017898", "PUB00017899", "PUB00025109", "PUB00026406", "PUB00043654" ]

[ "3288195", "6329717", "2229036", "1977073", "3762694", "3762695", "9872322", "2126155", "9873074", "11421269", "1282354", "9640644", "11988180", "11470432", "11402022", "11080142", "11532960", "11421270" ]

[ "A family of closely related ATP-binding subunits from prokaryotic and eukaryotic cells.", "Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.", "Binding protein-dependent transport systems.", "Stru...

[ 1988, 1982, 1990, 1990, 1986, 1986, 1998, 1990, 1999, 2001, 1992, 1998, 2002, 2001, 2001, 2000, 2001, 2001 ]

18

[ "IPR003593" ]

[ "IPR015853", "IPR015855", "IPR015856", "IPR015860", "IPR017879", "IPR017911", "IPR034001", "IPR034003", "IPR041701", "IPR047080", "IPR047082" ]

1

11

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "plasmids", "unclassified sequences" ]

[ 37604, 1931118, 320532, 151, 5, 26243 ]

6

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 583, 90, 184, 151, 79, 298, 173, 37, 455, 253, 31, 19, 967 ]

13

true

Domain

ABC transporter-like, ATP-binding domain

ABC_transporter-like_ATP-bd

3

IPR003440

3,440

Glycosyl transferase 48 domain

Glyco_trans_48_dom

Domain

11,970

false

This entry represents a domain found in glycosyltransferase 48 enzymes , including various 1,3-beta-glucan synthase components such as Gls1, Gls2 and Gls3 from yeast. 1,3-beta-glucan synthase ( ) also known as callose synthase catalyses the formation of a beta-1,3-glucan polymer that is a major component of the fungal ...

[ "GO:0003843", "GO:0006075", "GO:0000148", "GO:0016020" ]

[ "1,3-beta-D-glucan synthase activity", "(1->3)-beta-D-glucan biosynthetic process", "1,3-beta-D-glucan synthase complex", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component", "cellular_component" ]

4

[ "PFAM" ]

[ "PF02364" ]

[ "Glucan_synthase" ]

[ 11970 ]

1

[ "CAZY", "EC", "METACYC" ]

[ "GT48", "2.4.1.34", "PWY-6773" ]

[ "CAZY:GT48", "EC:2.4.1.34", "METACYC:PWY-6773" ]

3

[ "7xe4", "7yuy", "8jzn", "8wl6", "8wla" ]

5

[ "PUB00009409", "PUB00009566" ]

[ "9334165", "9209021" ]

[ "A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities.", "Cloning of the Candida albicans homolog of Saccharomyces cerevisiae GSC1/FKS1 and its involvement in beta-1,3-glucan synthesis." ]

[ 1997, 1997 ]

2

[]

0

null

[ "Eukaryota", "marine sediment metagenome" ]

[ 11969, 1 ]

2

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 63, 1, 49, 3, 4, 258 ]

6

true

Domain

Glycosyl transferase 48 domain

Glyco_trans_48_dom

7

IPR003441

3,441

NAC domain

NAC-dom

Domain

59,871

false

The NAC domain (for Petunia hybrida (Petunia) NAM and for Arabidopsis ATAF1, ATAF2, and CUC2) is an N-terminal module of ~160 amino acids, which is found in proteins of the NAC family of plant-specific transcriptional regulators (no apical meristem (NAM) proteins) [ ]. NAC proteins are involved in developmental process...

[ "GO:0003677", "GO:0006355" ]

[ "DNA binding", "regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PROFILE" ]

[ "PF02365", "PS51005" ]

[ "NAM", "NAC" ]

[ 58830, 59388 ]

2

[ "PROSITEDOC" ]

[ "PDOC51005" ]

[ "PROSITEDOC:PDOC51005" ]

1

[ "1ut4", "1ut7", "3swm", "3swp", "3ulx", "4dul", "7xlj", "7xp3" ]

8

[ "PUB00015417", "PUB00015418", "PUB00015419", "PUB00015420", "PUB00015421" ]

[ "9212461", "11114891", "12175016", "10660065", "15083810" ]

[ "Genes involved in organ separation in Arabidopsis: an analysis of the cup-shaped cotyledon mutant.", "Arabidopsis NAC1 transduces auxin signal downstream of TIR1 to promote lateral root development.", "Molecular characterization of AtNAM: a member of the Arabidopsis NAC domain superfamily.", "Molecular analy...

[ 1997, 2000, 2002, 2000, 2004 ]

5

[]

0

null

[ "Eukaryota", "European wheat striate mosaic virus", "Undibacterium baiyunense" ]

[ 59860, 10, 1 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 507, 404, 544 ]

3

true

Domain

NAC domain

NAC-dom

3

IPR003442

3,442

tRNA threonylcarbamoyl adenosine modification protein TsaE

T6A_TsaE

Domain

26,014

false

Members of this entry have a conserved nucleotide-binding motif GXXGXGKT and a nucleotide-binding fold. Member protein YjeE of Haemophilus influenzae (HI0065) was shown to have ATPase activity [ , ]. The protein has a nucleotide-binding fold with a four-stranded parallel β-sheet flanked by antiparallel β-strands on eac...

[ "GO:0002949" ]

[ "tRNA threonylcarbamoyladenosine modification" ]

[ "biological_process" ]

1

[ "PFAM", "NCBIFAM" ]

[ "PF02367", "TIGR00150" ]

[ "TsaE", "T6A_YjeE" ]

[ 26014, 25524 ]

2

[ "GP", "GP", "GP" ]

[ "GenProp1060", "GenProp1171", "GenProp1570" ]

[ "GP:GenProp1060", "GP:GenProp1171", "GP:GenProp1570" ]

3

[ "1fl9", "1htw", "5mvr", "5np9", "6n9a", "6nak", "6s84" ]

7

[ "PUB00016159", "PUB00063355", "PUB00063361", "PUB00063366" ]

[ "12112691", "22378793", "17581233", "23072323" ]

[ "Crystal structure of the YjeE protein from Haemophilus influenzae: a putative Atpase involved in cell wall synthesis.", "Biosynthesis of threonylcarbamoyl adenosine (t6A), a universal tRNA nucleoside.", "From bacterial genomes to novel antibacterial agents: discovery, characterization, and antibacterial activi...

[ 2002, 2012, 2007, 2012 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Yasminevirus sp. GU-2018", "candidate division MSBL1", "unclassified sequences" ]

[ 25137, 297, 1, 2, 577 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

tRNA threonylcarbamoyl adenosine modification protein TsaE

T6A_TsaE

6

IPR003443

3,443

Interleukin-15/Interleukin-21 family

IL-15/IL-21_fam

Family

1,970

false

Interleukins (IL) are a group of cytokines that play an important role in the immune system. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells. Interleukin-15 (IL-15) has a variety of biological functions, including stimulation and maintenance of cell...

[ "GO:0005126", "GO:0006955", "GO:0005576" ]

[ "cytokine receptor binding", "immune response", "extracellular region" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF02372", "PTHR14356" ]

[ "IL15", "" ]

[ 1720, 1920 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-8983432", "R-CFA-9020958", "R-HSA-8983432", "R-HSA-9020958", "R-MMU-8983432", "R-MMU-9020958", "R-RNO-8983432", "R-RNO-9020958" ]

[ "REACTOME:R-BTA-8983432", "REACTOME:R-CFA-9020958", "REACTOME:R-HSA-8983432", "REACTOME:R-HSA-9020958", "REACTOME:R-MMU-8983432", "REACTOME:R-MMU-9020958", "REACTOME:R-RNO-8983432", "REACTOME:R-RNO-9020958" ]

8

[ "2oqp", "2psm", "2xqb", "2z3q", "2z3r", "3tgx", "4gs7", "8ent" ]

8

[ "PUB00019742", "PUB00046028" ]

[ "10689297", "10784451" ]

[ "The emerging role of IL-15 in NK-cell development.", "Control of homeostasis of CD8+ memory T cells by opposing cytokines." ]

[ 2000, 2000 ]

2

[]

[ "IPR020439" ]

0

1

0

[ "Gnathostomata" ]

[ 1970 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 10, 3, 10, 6 ]

4

true

Family

Interleukin-15/Interleukin-21 family

IL-15/IL-21_fam

5

IPR003444

3,444

Transcriptional regulator MraZ

MraZ

Family

19,690

false

This entry represents the MraZ protein from bacteria. This protein often is found with other genes of the dcw (division cell wall) gene cluster, including mraW, ftsI, murE, murF, ftsW, murG, etc. In E. coli, MraZ is a DNA-binding transcription factor [ ]. It acts as a repressor of Pmra, which is a promoter for mraZ and...

[ "GO:0003700", "GO:0006355" ]

[ "DNA-binding transcription factor activity", "regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PANTHER", "NCBIFAM" ]

[ "MF_01008", "PTHR34701", "TIGR00242" ]

[ "MraZ", "", "" ]

[ 19487, 19647, 15384 ]

3

[]

0

[ "1n0e", "1n0f", "1n0g" ]

3

[ "PUB00074047" ]

[ "24659771" ]

[ "The highly conserved MraZ protein is a transcriptional regulator in Escherichia coli." ]

[ 2014 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences", "uncultured marine group II/III euryarchaeote KM3_94_C01" ]

[ 19176, 26, 487, 1 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Transcriptional regulator MraZ

MraZ

7

IPR003445

3,445

Cation transporter

Cat_transpt

Family

36,160

false

This family consists of various potassium transport proteins (Trk) and V-type sodium ATP synthase subunit J or translocating ATPase J ( ). These proteins are involved in active sodium uptake utilizing ATP in the process. TrkH from Escherichia coli is a hydrophobic membrane protein and determines the specificity and kin...

[ "GO:0008324", "GO:0006812", "GO:0055085" ]

[ "monoatomic cation transmembrane transporter activity", "monoatomic cation transport", "transmembrane transport" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "PFAM" ]

[ "PF02386" ]

[ "TrkH" ]

[ 36160 ]

1

[]

0

[ "3pjz", "4j7c", "4j9u", "5but", "6v4j", "6v4k", "6v4l", "7zp9", "7zpo", "7zpr", "8k1s", "8k1t", "8k1u", "8k66", "8k69", "8poo", "8w9n", "8w9o", "8w9t", "8w9v", "8xmh", "8xmi", "8y6j", "8y6l", "8y6m", "8y6n" ]

26

[ "PUB00009487", "PUB00099198", "PUB00099201" ]

[ "7896723", "31992706", "27803167" ]

[ "TrkH and its homolog, TrkG, determine the specificity and kinetics of cation transport by the Trk system of Escherichia coli.", "TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential.", "A Novel Putrescine Exporter SapBCDF of Escherichia coli." ]

[ 1995, 2020, 2016 ]

3

[]

[ "IPR004772", "IPR004773" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1523, 27434, 6600, 603 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 12, 2, 2, 17, 2, 2, 9 ]

7

true

Family

Cation transporter

Cat_transpt

9

IPR003446

3,446

Plasmid replication initiation, RepA

Plasmid_replication_init_RepA

Family

2,353

false

These proteins are plasmid encoded and essential for plasmid replication, they are also involved in copy control functions [ ].

[ "GO:0006276" ]

[ "plasmid maintenance" ]

[ "biological_process" ]

1

[ "NCBIFAM", "PFAM" ]

[ "NF040977", "PF02387" ]

[ "RepA_IncFII_LM", "IncFII_repA" ]

[ 2141, 2353 ]

2

[]

0

[]

0

[ "PUB00009486", "PUB00106107" ]

[ "3041379", "7543895" ]

[ "RepA protein- and oriR-dependent initiation of R1 plasmid replication: identification of a rho-dependent transcription terminator required for cis-action of repA protein.", "The replication of an IncL/M plasmid is subject to antisense control." ]

[ 1988, 1995 ]

2

[]

[ "IPR017837" ]

0

1

0

[ "Aliivibrio phage vB_Alvi_H905", "Bacteria", "Pancrustacea", "human gut metagenome", "plasmids" ]

[ 1, 2336, 10, 2, 4 ]

5

[]

0

true

Family

Plasmid replication initiation, RepA

Plasmid_replication_init_RepA

2

IPR003448

3,448

Molybdopterin biosynthesis MoaE

Mopterin_biosynth_MoaE

Family

23,530

false

Members of the MoaE family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT...

[ "GO:0006777" ]

[ "Mo-molybdopterin cofactor biosynthetic process" ]

[ "biological_process" ]

1

[ "PFAM", "CDD" ]

[ "PF02391", "cd00756" ]

[ "MoaE", "MoaE" ]

[ 23530, 22467 ]

2

[ "EC", "GP", "GP", "GP", "METACYC", "METACYC", "REACTOME" ]

[ "2.8.1.12", "GenProp0466", "GenProp1138", "GenProp1711", "PWY-6823", "PWY-7887", "R-HSA-947581" ]

[ "EC:2.8.1.12", "GP:GenProp0466", "GP:GenProp1138", "GP:GenProp1711", "METACYC:PWY-6823", "METACYC:PWY-7887", "REACTOME:R-HSA-947581" ]

7

[ "1fm0", "1fma", "1nvi", "1nvj", "2omd", "2q5w", "2qie", "2wp4", "3bii", "3rpf", "4ap8", "5mpo", "6jbz", "6jc0", "7l2a", "7l32", "8hlg", "9jbd" ]

18

[ "PUB00008129", "PUB00014872", "PUB00079807", "PUB00079808", "PUB00079809", "PUB00079810", "PUB00079811" ]

[ "8514782", "12571227", "12504674", "11913130", "10746556", "15709772", "12571226" ]

[ "The biosynthesis of molybdopterin in Escherichia coli. Purification and characterization of the converting factor.", "Structural studies of molybdopterin synthase provide insights into its catalytic mechanism.", "Structural biology of enzymes involved in NAD and molybdenum cofactor biosynthesis.", "Biosynthe...

[ 1993, 2003, 2002, 2002, 2000, 2005, 2003 ]

7

[]

[ "IPR028888" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 828, 18346, 3956, 400 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 3, 1, 1, 1, 1, 1, 3, 1, 2, 6, 3 ]

11

true

Family

Molybdopterin biosynthesis MoaE

Mopterin_biosynth_MoaE

8

IPR003449

3,449

Coronavirus protein 7

Corona_7

Family

132

false

This is a family of proteins from Coronavirus, which may function in the formation of membrane-bound replication complexes or in viral assembly.

[]

0

[ "PFAM" ]

[ "PF02398" ]

[ "Corona_7" ]

[ 132 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Alphacoronavirus 1" ]

[ 132 ]

1

[]

0

true

Family

Coronavirus protein 7

Corona_7

4

IPR003451

3,451

4-hydroxy-3-methylbut-2-enyl diphosphate reductase

LytB/IspH

Family

25,096

false

Terpenes are among the largest groups of natural products and include compounds such as vitamins, cholesterol and carotenoids. The biosynthesis of all terpenoids begins with one or both of the two C5 precursors of the pathway: isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). In animals, fungi, and c...

[ "GO:0046872", "GO:0051745", "GO:0019288", "GO:0050992" ]

[ "metal ion binding", "4-hydroxy-3-methylbut-2-enyl diphosphate reductase activity", "isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway", "dimethylallyl diphosphate biosynthetic process" ]

[ "molecular_function", "molecular_function", "biological_process", "biological_process" ]

4

[ "HAMAP", "PFAM", "PANTHER", "NCBIFAM", "CDD" ]

[ "MF_00191", "PF02401", "PTHR30426", "TIGR00216", "cd13944" ]

[ "IspH", "LYTB", "", "ispH_lytB", "lytB_ispH" ]

[ 23113, 25096, 22458, 24089, 24140 ]

5

[ "EC", "GP", "GP", "METACYC" ]

[ "1.17.7.4", "GenProp0048", "GenProp1295", "PWY-7560" ]

[ "EC:1.17.7.4", "GP:GenProp0048", "GP:GenProp1295", "METACYC:PWY-7560" ]

4

[ "3dnf", "3f7t", "3ke8", "3ke9", "3kef", "3kel", "3kem", "3szl", "3szo", "3szu", "3t0f", "3t0g", "3urk", "3utc", "3utd", "3uv3", "3uv6", "3uv7", "3uwm", "3zgl", "3zgn", "4eb3", "4h4c", "4h4d", "4h4e", "4mux", "4muy", "4mv0", "4mv5", "4n7b" ]

30

[ "PUB00007255", "PUB00007256", "PUB00015324", "PUB00097870", "PUB00097871" ]

[ "11004185", "11818558", "9537400", "16289098", "15863698" ]

[ "Evidence of a role for LytB in the nonmevalonate pathway of isoprenoid biosynthesis.", "Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein.", "Occurrence of homologs of the Escherichia coli lytB gene in gram-negative bacterial species.", "Reconstitution of an api...

[ 2000, 2002, 1998, 2005, 2005 ]

5

[]

0

null

[ "Bacteria", "Candidatus Iainarchaeum sp.", "Eukaryota", "metagenomes" ]

[ 22955, 2, 1495, 644 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 1, 8, 3 ]

4

true

Family

4-hydroxy-3-methylbut-2-enyl diphosphate reductase

LytB/IspH

7

IPR003452

3,452

Stem cell factor

SCF

Family

1,451

false

Stem cell factor (SCF) is a homodimer involved in hematopoiesis. SCF binds to and activates KIT, a receptor tyrosine kinase [ ]. SCF stimulates the proliferation of mast cells and is able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. It also mediates cell-ce...

[ "GO:0005173", "GO:0007155", "GO:0016020" ]

[ "stem cell factor receptor binding", "cell adhesion", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF02404", "PIRSF015599", "PTHR11574" ]

[ "SCF", "SCF", "" ]

[ 1408, 728, 1405 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1257604", "R-BTA-1433557", "R-BTA-1433559", "R-BTA-5673001", "R-BTA-6811558", "R-BTA-9856649", "R-CFA-1257604", "R-CFA-1433557", "R-CFA-1433559", "R-CFA-5673001", "R-CFA-6811558", "R-CFA-9856649", "R-GGA-1257604", "R-GGA-1433557", "R-GGA-1433559", "R-GGA-5673001", "R-GGA-68115...

[ "REACTOME:R-BTA-1257604", "REACTOME:R-BTA-1433557", "REACTOME:R-BTA-1433559", "REACTOME:R-BTA-5673001", "REACTOME:R-BTA-6811558", "REACTOME:R-BTA-9856649", "REACTOME:R-CFA-1257604", "REACTOME:R-CFA-1433557", "REACTOME:R-CFA-1433559", "REACTOME:R-CFA-5673001", "REACTOME:R-CFA-6811558", "REACTOM...

37

[ "1exz", "1scf", "2e9w", "2o26", "2o27", "8dfm", "8dfp", "8dfq" ]

8

[ "PUB00009483", "PUB00043971" ]

[ "10884405", "17662946" ]

[ "Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation.", "Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor." ]

[ 2000, 2007 ]

2

[]

0

null

[ "Candidatus Endonucleibacter bathymodioli", "Opisthokonta" ]

[ 1, 1450 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 5, 4 ]

4

true

Family

Stem cell factor

SCF

6

IPR003453

3,453

ABC transport permease subunit MlaE, proteobacteria

ABC_MlaE_roteobac

Family

15,191

false

This entry represents a subfamily of ABC transporter permease subunits. In it is involved in L-glutamate import into the cell [ ]. In it is involved in lipid transfer within the cell [ ]. In (MlaE) it is involved in phospholipid transport as part of the Mla system, whose role is preserving outer membrane lipid asymmetr...

[]

0

[ "NCBIFAM" ]

[ "TIGR00056" ]

[ "" ]

[ 15191 ]

1

[]

0

[ "6ic4", "6xbd", "6z5u", "6zy2", "6zy3", "6zy4", "6zy9", "7cge", "7cgn", "7ch0", "7ch6", "7ch7", "7ch8", "7ch9", "7cha", "7d06", "7d08", "7d09", "7d0a" ]

19

[ "PUB00057443", "PUB00057444", "PUB00059298" ]

[ "16495545", "12743031", "19383799" ]

[ "Identification of a meningococcal L-glutamate ABC transporter operon essential for growth in low-sodium environments.", "A permease-like protein involved in ER to thylakoid lipid transfer in Arabidopsis.", "An ABC transport system that maintains lipid asymmetry in the gram-negative outer membrane." ]

[ 2006, 2003, 2009 ]

3

[ "IPR030802" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 14225, 791, 175 ]

3

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 2, 2, 3, 2 ]

4

true

Family

ABC transport permease subunit MlaE, proteobacteria

ABC_MlaE_roteobac

9

IPR003454

3,454

Monooxygenase component MmoB/DmpM

MOase_MmoB_DmpM

Family

1,686

false

This entry represents a family of monooxygenase components that include Methane monooxygenase regulatory protein B (MmoB), and Phenol 2-monooxygenase, stimulatory component DmpM. When MmoB is present at low concentration it converts methane monooxygenase from an oxidase to a hydroxylase and stabilises intermediates req...

[ "GO:0004497" ]

[ "monooxygenase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF02406" ]

[ "MmoB_DmpM" ]

[ 1686 ]

1

[]

0

[ "1ckv", "1g10", "1g11", "1hqi", "2bf2", "2bf3", "2bf5", "2inn", "2inp", "2mob", "3dhh", "3dhi", "3ge3", "3ge8", "3i5j", "3i63", "3q14", "3q2a", "3q3m", "3q3n", "3q3o", "3ri7", "4gam", "5tdt", "5tdu", "5tdv", "6vk4", "6vk5", "6vk8", "6yd0", "6ydi", "6ydu"...

41

[ "PUB00009481", "PUB00009482", "PUB00025088", "PUB00088050", "PUB00088161" ]

[ "10393915", "9012665", "11297417", "9312093", "21183637" ]

[ "Structure of the soluble methane monooxygenase regulatory protein B.", "Solution structure of phenol hydroxylase protein component P2 determined by NMR spectroscopy.", "Solution structure of the toluene 4-monooxygenase effector protein (T4moD).", "Alkene monooxygenase from Xanthobacter strain Py2. Purificati...

[ 1999, 1997, 2001, 1997, 2011 ]

5

[]

0

null

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 17, 1652, 17 ]

3

[]

0

true

Family

Monooxygenase component MmoB/DmpM

MOase_MmoB_DmpM

2

IPR003457

3,457

Mercuric transport protein MerT

Transprt_MerT

Family

3,288

false

MerT is an mercuric transport integral membrane protein and is responsible for transport of the Hg2+ iron from periplasmic MerP (also part of the transport system) to mercuric reductase (MerA) [ , ].

[ "GO:0015097", "GO:0015694", "GO:0016020" ]

[ "mercury ion transmembrane transporter activity", "mercury ion transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF02411" ]

[ "MerT" ]

[ 3288 ]

1

[ "GP" ]

[ "GenProp0151" ]

[ "GP:GenProp0151" ]

1

[]

0

[ "PUB00078052", "PUB00078053" ]

[ "1328156", "3038684" ]

[ "Roles of the Tn21 merT, merP, and merC gene products in mercury resistance and mercury binding.", "Role of the merT and merP gene products of transposon Tn501 in the induction and expression of resistance to mercuric ions." ]

[ 1992, 1987 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "plasmids", "unclassified sequences" ]

[ 3204, 9, 3, 72 ]

4

[]

0

true

Family

Mercuric transport protein MerT

Transprt_MerT

7

IPR003458

3,458

Bacteriophage T4, Gp38, tail fibre assembly

Phage_T4_Gp38_tail_assem

Domain

9,526

false

This entry contains Bacteriophage T4 gp38 and related bacterial prophage and phage proteins. Gene 38 of phage T4 codes for a protein containing 183 amino acid residues with a molecular weight of 22.3kDa. Together with genes 36 and 37, whose products are structural proteins of the fibre distal part, gene 38 forms one tr...

[]

0

[ "PFAM" ]

[ "PF02413" ]

[ "Caudo_TAP" ]

[ 9526 ]

1

[]

0

[ "5yvq" ]

1

[ "PUB00009480", "PUB00015588", "PUB00015589" ]

[ "1531648", "8892827", "14625682" ]

[ "DNA sequences of the tail fiber genes of bacteriophage P2: evidence for horizontal transfer of tail fiber genes among unrelated bacteriophages.", "Characterization of the helper proteins for the assembly of tail fibers of coliphages T4 and lambda.", "Structure and morphogenesis of bacteriophage T4." ]

[ 1992, 1996, 2003 ]

3

[]

0

null

[ "Bacteria", "Opisthokonta", "Viruses", "metagenomes" ]

[ 9196, 17, 306, 7 ]

4

[ "Escherichia coli (strain K12)", "Mus musculus" ]

[ 8, 1 ]

2

true

Domain

Bacteriophage T4, Gp38, tail fibre assembly

Phage_T4_Gp38_tail_assem

5

IPR003459

3,459

Borrelia plasmid, OrfA

Borrelia_plasmid_OrfA

Family

871

false

The proteins in this entry are encoded by an open reading frame in plasmid borne DNA repeats of Borrelia species. This protein is known as ORF-A [ ]. The function of this putative protein is unknown.

[]

0

[ "PFAM" ]

[ "PF02414" ]

[ "Borrelia_orfA" ]

[ 871 ]

1

[]

0

[]

0

[ "PUB00009479" ]

[ "8636030" ]

[ "Circular and linear plasmids of Lyme disease spirochetes have extensive homology: characterization of a repeated DNA element." ]

[ 1996 ]

1

[]

0

null

[ "Borreliaceae" ]

[ 871 ]

1

[]

0

true

Family

Borrelia plasmid, OrfA

Borrelia_plasmid_OrfA

5

IPR003460

3,460

Insect antifreeze protein motif

Insect_antifreeze_prot_motif

Repeat

78

false

Antifreeze proteins (AFPs) are a class of proteins that are able to bind to and inhibit the growth of macromolecular ice, thereby permitting an organism to survive subzero temperatures by decreasing the probability of ice nucleation in their bodies [ ]. These proteins have been characterised from a variety of organisms...

[]

0

[ "PFAM" ]

[ "PF02420" ]

[ "AFP" ]

[ 78 ]

1

[]

0

[ "1ezg", "1l1i" ]

2

[ "PUB00015093", "PUB00015094" ]

[ "10917536", "15291806" ]

[ "Mimicry of ice structure by surface hydroxyls and water of a beta-helix antifreeze protein.", "Cold survival in freeze-intolerant insects: the structure and function of beta-helical antifreeze proteins." ]

[ 2000, 2004 ]

2

[]

0

null

[ "Eukaryota" ]

[ 78 ]

1

[]

0

true

Repeat

Insect antifreeze protein motif

Insect_antifreeze_prot_motif

4

IPR003461

3,461

Keratin

Family

16,543

false

Keratins are a well known group of intermediate filament proteins. Like actin filaments, keratins are flexible but provide a firm cell skeleton. Unlike actin, however, no known keratins are associated with motor functions. This family represents avian keratin proteins [ ], found in feathers, scale and claw. The avian k...

[ "GO:0005200", "GO:0005882" ]

[ "structural constituent of cytoskeleton", "intermediate filament" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF02422", "PTHR31203" ]

[ "Keratin", "" ]

[ 16539, 16449 ]

2

[]

0

[]

0

[ "PUB00009478" ]

[ "6200321" ]

[ "A comparison of genomic coding sequences for feather and scale keratins: structural and evolutionary implications." ]

[ 1984 ]

1

[]

0

null

[ "Euteleostomi" ]

[ 16543 ]

1

[]

0

true

Family

Keratin

6

IPR003463

3,463

Paralytic/GBP/PSP peptide

GBP_PSP

Family

66

false

This family includes insect peptides that are short (23 amino acids) and contain 1 disulphide bridge. The family includes growth-blocking peptide (GBP) of Pseudaletia separata (Oriental armyworm) and the paralytic peptides from Manduca sexta (Tobacco hawkmoth), Heliothis virescens (Noctuid moth), and Spodoptera exigua ...

[]

0

[ "PFAM" ]

[ "PF02425" ]

[ "GBP_PSP" ]

[ 66 ]

1

[]

0

[ "1b1v", "1b5n", "1bqf", "1hrl", "1irr", "1v28", "2dj9", "2djc", "2eqh", "2eqq", "2eqt" ]

11

[ "PUB00009474", "PUB00009475" ]

[ "2071576", "9988679" ]

[ "Isolation and identification of paralytic peptides from hemolymph of the lepidopteran insects Manduca sexta, Spodoptera exigua, and Heliothis virescens.", "Structure of the insect cytokine peptide plasmatocyte-spreading peptide 1 from Pseudoplusia includens." ]

[ 1991, 1999 ]

2

[]

0

null

[ "Endopterygota" ]

[ 66 ]

1

[]

0

true

Family

Paralytic/GBP/PSP peptide

GBP_PSP

7

IPR003464

3,464

Muconolactone delta-isomerase

Muconolactone_d_Isoase

Family

3,117

false

This small enzyme forms a homodecameric complex, that catalyses the third step in the catabolism of catechol to succinate- and acetyl-coa in the beta-ketoadipate pathway ( ).

[]

0

[ "PIRSF", "NCBIFAM" ]

[ "PIRSF001486", "TIGR03221" ]

[ "CatC", "muco_delta" ]

[ 3097, 2773 ]

2

[ "EC", "GP", "METACYC" ]

[ "5.3.3.4", "GenProp0711", "PWY-6185" ]

[ "EC:5.3.3.4", "GP:GenProp0711", "METACYC:PWY-6185" ]

3

[ "1mli", "3znj", "3znu", "3zo7", "4fpi" ]

5

[]

0

[]

0

null

[ "Bacteria", "Pleodorina starrii", "metagenomes" ]

[ 3103, 1, 13 ]

3

[]

0

true

Family

Muconolactone delta-isomerase

Muconolactone_d_Isoase

1

IPR003465

3,465

Proteinase inhibitor I20

Prot_inh_I20

Family

794

false

Members of the potato peptidase inhibitor II family are proteinase inhibitors that belong to MEROPS inhibitor family I20, clan IA and are restricted to plants. They inhibit serine peptidases belonging to MEROPS peptidase family S1 [ ] ( ). They have a multidomain structure [ ], which permits circular permutation of the...

[ "GO:0004867" ]

[ "serine-type endopeptidase inhibitor activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF02428" ]

[ "Prot_inhib_II" ]

[ 794 ]

1

[]

0

[ "1ce3", "1fyb", "1oyv", "1pju", "1qh2", "1tih", "1ytp", "2jyy", "2jzm", "4sgb", "5zfo" ]

11

[ "PUB00005742", "PUB00009473", "PUB00014123", "PUB00014124", "PUB00014125", "PUB00014126", "PUB00014129", "PUB00014133" ]

[ "7610480", "2494344", "11604534", "4506778", "11216843", "11351092", "12446136", "14705960" ]

[ "Swaposins: circular permutations within genes encoding saposin homologues.", "Structure of the complex of Streptomyces griseus proteinase B and polypeptide chymotrypsin inhibitor-1 from Russet Burbank potato tubers at 2.1 A resolution.", "Proteins of circularly permuted sequence present within the same organis...

[ 1995, 1989, 2001, 1972, 2001, 2001, 2002, 2004 ]

8

[]

0

null

[ "Tracheophyta" ]

[ 794 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 2, 2 ]

3

true

Family

Proteinase inhibitor I20

Prot_inh_I20

1

IPR003467

3,467

K88 fimbrial minor subunit FaeH

Fimbrial_K88_FaeH

Family

880

false

Fimbriae (also know as pili) are polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers, that enable bacteria to colonise the epithelium of specific host organs [ ]. This family represents the K88 minor fimbrial subunit FaeH and related proteins.

[ "GO:0007155", "GO:0009289" ]

[ "cell adhesion", "pilus" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF02432" ]

[ "Fimbrial_K88" ]

[ 880 ]

1

[]

0

[ "2j6g", "2j6r", "3gea", "3gew", "3gfu", "3ggh", "3hlr", "4we2", "4wei", "4wem", "4wen", "4weu" ]

12

[ "PUB00019554" ]

[ "9393819" ]

[ "Identification and characterization of a K88- and CS31A-like operon of a rabbit enteropathogenic Escherichia coli strain which encodes fimbriae involved in the colonization of rabbit intestine." ]

[ 1997 ]

1

[]

0

null

[ "Pseudomonadota" ]

[ 880 ]

1

[]

0

true

Family

K88 fimbrial minor subunit FaeH

Fimbrial_K88_FaeH

8

IPR003468

3,468

Cytochrome c oxidase, monohaem subunit/FixO

Cyt_c_oxidase_monohaem-su/FixO

Family

10,162

false

Cytochrome cbb3 oxidases are found almost exclusively in Proteobacteria, and represent a distinctive class of proton-pumping respiratory haem-copper oxidases (HCO) that lack many of the key structural features that contribute to the reaction cycle of the intensely studied mitochondrial cytochrome c oxidase (CcO) [ ]. C...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF02433", "TIGR00781" ]

[ "FixO", "ccoO" ]

[ 10162, 8959 ]

2

[ "GP" ]

[ "GenProp0483" ]

[ "GP:GenProp0483" ]

1

[ "3mk7", "5djq", "6xkw", "6xkx", "6xkz", "8smr", "8snh" ]

7

[ "PUB00014947", "PUB00016261" ]

[ "15100055", "11864982" ]

[ "The bacterial cytochrome cbb3 oxidases.", "Oxygen adaptation. The role of the CcoQ subunit of the cbb3 cytochrome c oxidase of Rhodobacter sphaeroides 2.4.1." ]

[ 2004, 2002 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanosarcinaceae", "unclassified sequences" ]

[ 9999, 17, 5, 141 ]

4

[]

0

true

Family

Cytochrome c oxidase, monohaem subunit/FixO

Cyt_c_oxidase_monohaem-su/FixO

6

IPR003469

3,469

Glycoside hydrolase, family 68

Glyco_hydro_68

Family

1,994

false

This family consists of the glycosyl hydrolase 68 family ( ), including several bacterial levansucrase enzymes, and invertase from Zymomonas. Levansucrase ( ), also known as beta-D-fructofuranosyl transferase, catalyses the conversion of sucrose and (2,6-beta-D-fructosyl)(N) to glucose and (2,6-beta-D-fructosyl)(N+1), ...

[ "GO:0050053", "GO:0009758" ]

[ "levansucrase activity", "carbohydrate utilization" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "CDD" ]

[ "PF02435", "cd08997" ]

[ "Glyco_hydro_68", "GH68" ]

[ 1994, 1683 ]

2

[ "CAZY", "EC", "METACYC" ]

[ "GH68", "2.4.1.10", "PWY-822" ]

[ "CAZY:GH68", "EC:2.4.1.10", "METACYC:PWY-822" ]

3

[ "1oyg", "1pt2", "1w18", "2vdt", "2yfr", "2yfs", "2yft", "3byj", "3byk", "3byl", "3byn", "3om2", "3om4", "3om5", "3om6", "3om7", "3vsr", "3vss", "3wpu", "3wpv", "3wpy", "3wpz", "4d47", "6frw", "6m0d", "6m0e", "6pwq", "6rv5", "6vhq", "7bj4", "7bj5", "7bjc"...

44

[ "PUB00004870", "PUB00005266" ]

[ "7624375", "8535779" ]

[ "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.", "Structures and mechanisms of glycosyl hydrolases." ]

[ 1995, 1995 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "ecological metagenomes" ]

[ 1852, 3, 137, 2 ]

4

[]

0

true

Family

Glycoside hydrolase, family 68

Glyco_hydro_68

8

IPR003470

3,470

Adenovirus E3 region protein CR2

Adeno_E3_CR2

Domain

275

false

Early region 3 (E3) of human adenoviruses (Ads) codes for proteins that appear to control viral interactions with the host [ ]. This region called CR1 (conserved region 1) [ ] is found three times in Human adenovirus 19 (a subgroup D adenovirus) 49kDa protein in the E3 region. CR1 is also found in the 20.1 Kd protein o...

[]

0

[ "PFAM" ]

[ "PF02439" ]

[ "Adeno_E3_CR2" ]

[ 275 ]

1

[]

0

[]

0

[ "PUB00009472" ]

[ "8627757" ]

[ "Early region 3 of adenovirus type 19 (subgroup D) encodes an HLA-binding protein distinct from that of subgroups B and C." ]

[ 1996 ]

1

[]

0

null

[ "Mastadenovirus" ]

[ 275 ]

1

[]

0

true

Domain

Adenovirus E3 region protein CR2

Adeno_E3_CR2

2

IPR003471

3,471

Adenovirus E3 region protein CR1

Adeno_E3_CR1

Domain

345

false

Early region 3 (E3) of human adenoviruses (Ads) codes for proteins that appear to control viral interactions with the host [ ]. This region called CR1 (conserved region 1) [ ] is found three times in Human adenovirus 19 (a subgroup D virus) 49 Kd protein in the E3 region. CR1 is also found in the 20.1 Kd protein of sub...

[]

0

[ "PFAM" ]

[ "PF02440" ]

[ "Adeno_E3_CR1" ]

[ 345 ]

1

[]

0

[ "8vse" ]

1

[ "PUB00009472" ]

[ "8627757" ]

[ "Early region 3 of adenovirus type 19 (subgroup D) encodes an HLA-binding protein distinct from that of subgroups B and C." ]

[ 1996 ]

1

[]

0

null

[ "Protostomia", "Viruses" ]

[ 6, 339 ]

2

[]

0

true

Domain

Adenovirus E3 region protein CR1

Adeno_E3_CR1

2

IPR003472

3,472

Virion membrane protein, poxvirus L1-related

Virion_mem_poxvirus_L1

Family

388

false

The four families of large eukaryotic DNA viruses, Poxviridae, Asfarviridae, Iridoviridae, and Phycodnaviridae, referred to collectively as nucleocytoplasmic large DNA viruses or NCLDV, have all been shown to have a lipid membrane, in spite of the major differences in virion structure. The paralogous genes L1R and F9L ...

[]

0

[ "PFAM" ]

[ "PF02442" ]

[ "L1R_F9L" ]

[ 388 ]

1

[]

0

[ "1ypy", "2i9l", "4u6h", "6cj6", "8hif", "8zu9", "8zua", "9j7y", "9lf8", "9vhz" ]

10

[ "PUB00033628", "PUB00100256" ]

[ "11689653", "19793823" ]

[ "Common origin of four diverse families of large eukaryotic DNA viruses.", "The African swine fever virus virion membrane protein pE248R is required for virus infectivity and an early postentry event." ]

[ 2001, 2009 ]

2

[]

0

null

[ "Elysia marginata", "Nucleocytoviricota", "seawater metagenome" ]

[ 1, 386, 1 ]

3

[]

0

true

Family

Virion membrane protein, poxvirus L1-related

Virion_mem_poxvirus_L1

1

IPR003473

3,473

Quinolinate synthetase A

NadA

Family

20,777

false

Quinolinate synthetase catalyses the second step of the de novo biosynthetic pathway of pyridine nucleotide formation. In particular, quinolinate synthetase is involved in the condensation of dihydroxyacetone phosphate and iminoaspartate to form quinolinic acid [ ]. This synthesis requires two enzymes, an FAD-containin...

[ "GO:0008987", "GO:0051539", "GO:0009435" ]

[ "quinolinate synthetase A activity", "4 iron, 4 sulfur cluster binding", "NAD+ biosynthetic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM", "PANTHER", "NCBIFAM" ]

[ "PF02445", "PTHR30573", "TIGR00550" ]

[ "NadA", "", "nadA" ]

[ 20692, 20629, 19092 ]

3

[ "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.5.1.72", "GenProp0057", "PWY-5316", "PWY-7342", "PWY-8277", "PWY-8352" ]

[ "EC:2.5.1.72", "GP:GenProp0057", "METACYC:PWY-5316", "METACYC:PWY-7342", "METACYC:PWY-8277", "METACYC:PWY-8352" ]

6

[ "1wzu", "4hhe", "4p3x", "4zk6", "5f33", "5f35", "5f3d", "5ktm", "5ktn", "5kto", "5ktp", "5ktr", "5kts", "5ktt", "5lqm", "5lqs", "6f48", "6f4d", "6f4l", "6g74", "6i0k", "6i0p", "6i0r", "6nso", "6nsu", "6or8", "6ora", "7p4m", "7p4p", "7p4q" ]

30

[ "PUB00009471", "PUB00070332" ]

[ "10648170", "18803397" ]

[ "Cloning, overexpression, and purification of Escherichia coli quinolinate synthetase.", "Characterization of quinolinate synthases from Escherichia coli, Mycobacterium tuberculosis, and Pyrococcus horikoshii indicates that [4Fe-4S] clusters are common cofactors throughout this class of enzymes." ]

[ 2000, 2008 ]

2

[]

[ "IPR023066", "IPR023513", "IPR023515" ]

0

3

0

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctBLh2", "unclassified sequences" ]

[ 751, 18521, 908, 1, 596 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 1, 4, 8 ]

4

true

Family

Quinolinate synthetase A

NadA

8

IPR003474

3,474

Gluconate transporter

Glcn_transporter

Family

32,176

false

This is a family of integral membrane permeases that are involved in gluconate uptake. Escherichia coli contains several members of this family including GntU, a low affinity transporter [ ] and GntT, a high affinity transporter [ ].

[ "GO:0015128", "GO:0035429", "GO:0016020" ]

[ "gluconate transmembrane transporter activity", "gluconate transmembrane transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PIRSF", "PANTHER", "NCBIFAM" ]

[ "PF02447", "PIRSF002746", "PTHR30354", "TIGR00791" ]

[ "GntP_permease", "Gluconate_transporter", "", "gntP" ]

[ 26578, 17619, 31972, 17413 ]

4

[]

0

[]

0

[ "PUB00009469", "PUB00009470" ]

[ "9135111", "9045817" ]

[ "Gene organization and transcriptional regulation of the gntRKU operon involved in gluconate uptake and catabolism of Escherichia coli.", "Molecular genetic characterization of the Escherichia coli gntT gene of GntI, the main system for gluconate metabolism." ]

[ 1997, 1997 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "unclassified sequences" ]

[ 31705, 28, 302, 141 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)" ]

[ 1, 7 ]

2

true

Family

Gluconate transporter

Glcn_transporter

6

IPR003476

3,476

Glycoside hydrolase, family 42

Glyco_hydro_42

Family

13,118

false

O-Glycosyl hydrolases ( ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ ,...

[ "GO:0004565", "GO:0005975" ]

[ "beta-galactosidase activity", "carbohydrate metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF", "PANTHER" ]

[ "PIRSF001084", "PTHR36447" ]

[ "B-galactosidase", "" ]

[ 10384, 13118 ]

2

[ "CAZY", "EC", "METACYC" ]

[ "GH42", "3.2.1.23", "PWY-6807" ]

[ "CAZY:GH42", "EC:3.2.1.23", "METACYC:PWY-6807" ]

3

[ "1kwg", "1kwk", "3tts", "3tty", "4oif", "4ucf", "4uni", "4uoq", "4uoz", "4uzs", "5dfa", "5e9a", "5vym", "5xb7", "6lvw", "6t5o", "6t6g", "6t75", "6t7g", "6y2k", "7omi", "7oms", "8ibr", "8ibs", "8ibt" ]

25

[ "PUB00004870", "PUB00005266" ]

[ "7624375", "8535779" ]

[ "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.", "Structures and mechanisms of glycosyl hydrolases." ]

[ 1995, 1995 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 106, 12701, 233, 78 ]

4

[]

0

true

Family

Glycoside hydrolase, family 42

Glyco_hydro_42

4

IPR003477

3,477

mRNA interferase PemK-like

PemK-like

Family

25,477

false

PemK is a growth inhibitor in Escherichia coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. It is responsible for mediating cell death through inhibiting protein synthesis through the cleavage of single-stranded RNA. PemK is part of the PemK-PemI system, where PemI is an antitoxin ...

[ "GO:0003677" ]

[ "DNA binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF02452", "PIRSF033490", "PTHR33988" ]

[ "PemK_toxin", "MazF", "" ]

[ 25477, 8386, 15778 ]

3

[ "GP" ]

[ "GenProp0321" ]

[ "GP:GenProp0321" ]

1

[ "1m1f", "1ne8", "1ub4", "2c06", "2mf2", "3nfc", "4hke", "4mdx", "4me7", "4mzm", "4mzp", "4mzt", "4of1", "5cca", "5ck9", "5ckb", "5ckd", "5cke", "5ckf", "5ckh", "5co7", "5cqx", "5cqy", "5cr2", "5dlo", "5hjz", "5hk0", "5hk3", "5hkc", "5uct", "5wyg", "5xe2"...

61

[ "PUB00016245" ]

[ "15024022" ]

[ "Interference of mRNA function by sequence-specific endoribonuclease PemK." ]

[ 2004 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Opisthokonta", "Viruses", "plasmids", "unclassified sequences" ]

[ 556, 24139, 213, 99, 2, 468 ]

6

[ "Escherichia coli (strain K12)" ]

[ 3 ]

1

true

Family

mRNA interferase PemK-like

PemK-like

7

IPR003479

3,479

Pre-hexon-linking protein IIIa

Hex_IIIa

Family

451

false

The major capsid protein of the adenovirus strain is also known as a hexon. This entry represents protein IIIa, which is a hexon-associated protein that is likely to participate in vertex stabilisation and genome packaging. It stabilises vertices by tethering the penton bases to neighbouring peripentonal hexons, and la...

[ "GO:0019028" ]

[ "viral capsid" ]

[ "cellular_component" ]

1

[ "HAMAP", "PFAM" ]

[ "MF_04047", "PF02455" ]

[ "ADV_CAP3", "Hex_IIIa" ]

[ 331, 451 ]

2

[]

0

[ "6b1t", "6cgv", "6qi5", "6yba", "6z7n", "7rd1", "7s78", "7tau", "8roq", "9lr9" ]

10

[ "PUB00076672", "PUB00076673" ]

[ "21632753", "20798312" ]

[ "Adenovirus structural protein IIIa is involved in the serotype specificity of viral DNA packaging.", "Atomic structure of human adenovirus by cryo-EM reveals interactions among protein networks." ]

[ 2011, 2010 ]

2

[]

0

null

[ "Adenoviridae", "Mycobacterium simiae complex" ]

[ 448, 3 ]

2

[]

0

true

Family

Pre-hexon-linking protein IIIa

Hex_IIIa

8

IPR003481

3,481

Flagellar hook-associated protein 2, N-terminal

FliD_N

Domain

12,256

false

The flagellar hook-associated protein 2 (HAP2 or FliD) forms the distal end of the flagella, and plays a role in mucin specific adhesion of the bacteria [ ]. This entry represents the N-terminal region of this family of proteins.

[ "GO:0009424" ]

[ "bacterial-type flagellum hook" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF02465" ]

[ "FliD_N" ]

[ 12256 ]

1

[ "GP" ]

[ "GenProp0882" ]

[ "GP:GenProp0882" ]

1

[ "5h5v", "6sih", "9gnz", "9gsx", "9m6h" ]

5

[ "PUB00009465" ]

[ "9488388" ]

[ "The Pseudomonas aeruginosa flagellar cap protein, FliD, is responsible for mucin adhesion." ]

[ 1998 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 12092, 28, 136 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Flagellar hook-associated protein 2, N-terminal

FliD_N

3

IPR003482

3,482

Transcription factor WhiB

Whib

Family

26,196

false

WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation. The process of mycelium formation in Streptomyces, which occurs in response to nutrient limitation, is controlled by a number of whi genes, named for the white colour of aerial hyphae when mutations occur in these g...

[]

0

[ "HAMAP", "PANTHER" ]

[ "MF_01479", "PTHR38839" ]

[ "WhiB", "" ]

[ 24960, 25970 ]

2

[]

0

[ "5oay", "6ono", "6onu", "7f7n", "7kif", "7kim", "7kuf", "7kug", "8cwr", "8cwt", "8cyf", "8d5v", "8dy7", "8dy9" ]

14

[ "PUB00020553" ]

[ "8506145" ]

[ "Streptomyces aureofaciens whiB gene encoding putative transcription factor essential for differentiation." ]

[ 1993 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 24911, 6, 591, 688 ]

4

[]

0

true

Family

Transcription factor WhiB

Whib

9

IPR003484

3,484

N-acyltransferase NodA

NodA

Family

3,394

false

Rhizobial nodulation (Nod) factors are signalling molecules secreted by root-nodulating rhizobia in response to flavanoids excreted by the host plant. They induce various symbiotic responses on the roots of the leguminous host plant at low concentrations, and are required for successful infection [ ]. Nodulation factor...

[ "GO:0016746", "GO:0005829" ]

[ "acyltransferase activity", "cytosol" ]

[ "molecular_function", "cellular_component" ]

2

[ "HAMAP", "PFAM", "NCBIFAM" ]

[ "MF_00084", "PF02474", "TIGR04245" ]

[ "NodA", "NodA", "nodulat_NodA" ]

[ 784, 3394, 2680 ]

3

[ "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "...

[ "2.3.1.-", "GenProp1026", "PWY-3602", "PWY-361", "PWY-4801", "PWY-4922", "PWY-5048", "PWY-5139", "PWY-5268", "PWY-5284", "PWY-5292", "PWY-5307", "PWY-5313", "PWY-5317", "PWY-5318", "PWY-5353", "PWY-5400", "PWY-5473", "PWY-5475", "PWY-5477", "PWY-5660", "PWY-5679", "PWY-57...

[ "EC:2.3.1.-", "GP:GenProp1026", "METACYC:PWY-3602", "METACYC:PWY-361", "METACYC:PWY-4801", "METACYC:PWY-4922", "METACYC:PWY-5048", "METACYC:PWY-5139", "METACYC:PWY-5268", "METACYC:PWY-5284", "METACYC:PWY-5292", "METACYC:PWY-5307", "METACYC:PWY-5313", "METACYC:PWY-5317", "METACYC:PWY-5318...

221

[]

0

[ "PUB00016973", "PUB00016974" ]

[ "11732607", "8930915" ]

[ "Nod genes and Nod signals and the evolution of the Rhizobium legume symbiosis.", "The NodA proteins of Rhizobium meliloti and Rhizobium tropici specify the N-acylation of Nod factors by different fatty acids." ]

[ 2001, 1996 ]

2

[]

0

null

[ "Bacteria" ]

[ 3394 ]

1

[]

0

true

Family

N-acyltransferase NodA

NodA

1

IPR003485

3,485

Herpesvirus US2, varicellovirus-type

Herpes_US2_varicellovirus

Family

512

false

This is a family of unique short (US) region proteins from Herpesviridae strains. The US2 family has no known function.

[]

0

[ "PFAM" ]

[ "PF02476" ]

[ "US2" ]

[ 512 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Alphaherpesvirinae" ]

[ 512 ]

1

[]

0

true

Family

Herpesvirus US2, varicellovirus-type

Herpes_US2_varicellovirus

4

IPR003486

3,486

Nucleocapsid N protein

Nairo_nucleocap

Family

1,934

false

The nucleoprotein of the ssRNA negative-strand Nairovirus is an internal part of the virus particle.

[ "GO:0019013" ]

[ "viral nucleocapsid" ]

[ "cellular_component" ]

1

[ "PFAM", "PIRSF" ]

[ "PF02477", "PIRSF003950" ]

[ "Nairo_nucleo", "N_NairoV" ]

[ 1934, 160 ]

2

[]

0

[ "3u3i", "4akl", "4aqf", "4aqg", "4xz8", "4xza", "4xzc", "4xze", "5a97", "6z0o" ]

10

[]

0

[]

0

null

[ "Arachnida", "Polyploviricotina" ]

[ 10, 1924 ]

2

[]

0

true

Family

Nucleocapsid N protein

Nairo_nucleocap

1

IPR003487

3,487

Phosphoprotein, pneumoviral

Pprotein_pneumovir

Family

1,275

false

This family represents a phosphoprotein from Paramyxoviridae, which could be a putative RNA polymerase alpha subunit that may function in template binding [ ].

[ "GO:0003968" ]

[ "RNA-directed RNA polymerase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF02478" ]

[ "Pneumo_phosprot" ]

[ 1275 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-9820960", "R-HSA-9820962", "R-HSA-9828642", "R-HSA-9828721", "R-HSA-9828806", "R-HSA-9833110", "R-HSA-9834752" ]

[ "REACTOME:R-HSA-9820960", "REACTOME:R-HSA-9820962", "REACTOME:R-HSA-9828642", "REACTOME:R-HSA-9828721", "REACTOME:R-HSA-9828806", "REACTOME:R-HSA-9833110", "REACTOME:R-HSA-9834752" ]

7

[ "4bxt", "5fvd", "5oix", "5oiy", "6pzk", "6u5o", "6uen", "6yp5", "8fpi", "8fpj", "8fu3", "8snx", "8sny", "9c7y", "9ecv", "9ed2", "9n36" ]

17

[ "PUB00020145" ]

[ "7996153" ]

[ "Molecular cloning and sequence analysis of the phosphoprotein, nucleocapsid protein, matrix protein and 22K (M2) protein of the ovine respiratory syncytial virus." ]

[ 1994 ]

1

[]

0

null

[ "Alteromonas aestuariivivens", "Pneumoviridae" ]

[ 1, 1274 ]

2

[]

0

true

Family

Phosphoprotein, pneumoviral

Pprotein_pneumovir

3

IPR003488

3,488

DNA recombination-mediator protein A

DprA

Family

29,410

false

DprA is a new member of the recombination-mediator protein family, dedicated to natural bacterial transformation [ ]. In Helicobacter pylori, DprA is required for natural chromosomal and plasmid transformation [ ]. It has now been shown that DprA binds cooperatively to single-stranded DNA (ssDNA) and interacts with Rec...

[ "GO:0009294" ]

[ "DNA-mediated transformation" ]

[ "biological_process" ]

1

[ "PANTHER" ]

[ "PTHR43022" ]

[ "" ]

[ 29410 ]

1

[]

0

[ "3maj", "3uqz", "4ljk", "4ljl", "4ljr", "5mll", "8zva" ]

7

[ "PUB00009463", "PUB00044733", "PUB00078829" ]

[ "10640603", "17803906", "23440217" ]

[ "The dprA gene is required for natural transformation of Helicobacter pylori.", "A key presynaptic role in transformation for a widespread bacterial protein: DprA conveys incoming ssDNA to RecA.", "Direct involvement of DprA, the transformation-dedicated RecA loader, in the shut-off of pneumococcal competence."...

[ 2000, 2007, 2013 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 48, 28730, 47, 9, 576 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

DNA recombination-mediator protein A

DprA

5

IPR003489

3,489

Ribosome hibernation promoting factor/RaiA

RHF/RaiA

Family

30,756

false

This family consists of ribosome hibernation promoting factor (RHF). RHF promotes and stabilizes dimerization of 70S ribosomes by the ribosome modulation factor (RMF), leading to the formation of inactive 100S ribosomes during the stationary phase [ ].

[ "GO:0044238" ]

[ "primary metabolic process" ]

[ "biological_process" ]

1

[ "PFAM", "NCBIFAM", "CDD" ]

[ "PF02482", "TIGR00741", "cd00552" ]

[ "Ribosomal_S30AE", "yfiA", "RaiA" ]

[ 30750, 25350, 23434 ]

3

[]

0

[ "1imu", "1l4s", "1n3g", "2rql", "2ywq", "3tqm", "4hei", "4v4g", "4v8h", "4v8i", "4y4o", "5fdu", "5fdv", "5mmj", "5mmm", "5myj", "5nd8", "5nd9", "5ngm", "5njt", "5v8i", "5x8p", "5x8r", "5zep", "6cfk", "6cfl", "6dzi", "6dzk", "6eri", "6fkr", "6fxc", "6gzq"...

71

[ "PUB00026921", "PUB00037968", "PUB00080269", "PUB00080504" ]

[ "12392550", "15502846", "18174192", "15219834" ]

[ "Ribosome-associated factor Y adopts a fold resembling a double-stranded RNA binding domain scaffold.", "Structural basis for the control of translation initiation during stress.", "Role of HPF (hibernation promoting factor) in translational activity in Escherichia coli.", "The ribosome-associated inhibitor A...

[ 2002, 2004, 2008, 2004 ]

4

[]

[ "IPR034694" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 49, 29421, 801, 64, 421 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 2, 5, 3 ]

4

true

Family

Ribosome hibernation promoting factor/RaiA

RHF/RaiA

8

IPR003490

3,490

Rhabdovirus non-virion protein

Rhabd_NV

Family

48

false

Infectious hematopoietic necrosis virus (IHNV) is a member of the family Rhabdoviridae. The non-virion protein (NV) is coded for by one of the six genes of the IHNV genome [ ], but is absent in vesiculovirus-like rhabdovirus [ ].

[]

0

[ "PFAM" ]

[ "PF02484" ]

[ "Rhabdo_NV" ]

[ 48 ]

1

[]

0

[]

0

[ "PUB00009460", "PUB00009461" ]

[ "8578857", "9010293" ]

[ "The complete genome structure and phylogenetic relationship of infectious hematopoietic necrosis virus.", "Distribution and variation of NV genes in fish rhabdoviruses." ]

[ 1995, 1997 ]

2

[]

0

null

[ "Novirhabdovirus" ]

[ 48 ]

1

[]

0

true

Family

Rhabdovirus non-virion protein

Rhabd_NV

7

IPR003491

3,491

Replication initiation protein-like, C-terminal

REP-like_C

Domain

3,789

false

Plasmid replication is initiated by the replication initiation factor (REP). This entry represents the C-terminal domain of Replication initiation protein from Staphylococcus aureus and similar proteins mainly found in firmicutes and proteobacteria. Many members are probable specific topoisomerase that make a sequence-...

[]

0

[ "PFAM" ]

[ "PF02486" ]

[ "Rep_trans" ]

[ 3789 ]

1

[]

0

[ "4cij", "4cwe" ]

2

[ "PUB00009459", "PUB00151417" ]

[ "7735128", "17693500" ]

[ "Cerebrin-50, a human cerebrospinal fluid protein whose mRNA is present in multiple tissues but predominantly expressed in the lymphoblastoid cells and the brain.", "Identification of the origin of transfer (oriT) and DNA relaxase required for conjugation of the integrative and conjugative element ICEBs1 of Bacil...

[ 1995, 2007 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Plasmid pC223", "Viruses", "unclassified sequences" ]

[ 3631, 9, 1, 75, 73 ]

5

[]

0

true

Domain

Replication initiation protein-like, C-terminal

REP-like_C

4

IPR003492

3,492

Batten's disease protein Cln3

Battenin_disease_Cln3

Family

5,061

false

Batten's disease, the juvenile variant of neuronal ceroid lipofuscionosis (NCL), is a recessively inherited disorder affecting children of 5-10 years of age. The disease is characterised by progressive loss of vision, seizures and psychomotor disturbances. Biochemically, the disease is characterised by lysosomal accumu...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "PRINTS", "PANTHER" ]

[ "PF02487", "PR01315", "PTHR10981" ]

[ "CLN3", "BATTENIN", "" ]

[ 5025, 4628, 4832 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-9845576", "R-MMU-9845576", "R-SCE-9845576", "R-SPO-9845576" ]

[ "REACTOME:R-HSA-9845576", "REACTOME:R-MMU-9845576", "REACTOME:R-SCE-9845576", "REACTOME:R-SPO-9845576" ]

4

[]

0

[ "PUB00009450", "PUB00009451", "PUB00009452", "PUB00009453", "PUB00009454", "PUB00009455", "PUB00009456", "PUB00009457", "PUB00009458" ]

[ "7553855", "2142158", "9311735", "10191115", "10191114", "1482112", "7716512", "10191112", "9384607" ]

[ "Isolation of a novel gene underlying Batten disease, CLN3. The International Batten Disease Consortium.", "Characterization and cloning of lgp110, a lysosomal membrane glycoprotein from mouse and rat cells.", "Spectrum of mutations in the Batten disease gene, CLN3.", "Expression studies of CLN3 protein (batt...

[ 1995, 1990, 1997, 1999, 1999, 1992, 1995, 1999, 1998 ]

9

[]

[ "IPR018460" ]

0

1

0

[ "Bacteria", "Eukaryota" ]

[ 7, 5054 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 7, 1, 2, 36, 9, 1, 8, 1, 1 ]

9

true

Family

Batten's disease protein Cln3

Battenin_disease_Cln3

5

IPR003493

3,493

Herpesvirus glycoprotein H

Herpes_gH

Family

650

false

Herpesviruses are enveloped by a lipid bilayer that contains at least a dozen glycoproteins. The virion surface glycoproteins mediate recognition of susceptible cells and promote fusion of the viral envelope with the cell membrane, leading to virus entry. No single glycoprotein associated with the virion membrane has b...

[]

0

[ "HAMAP" ]

[ "MF_04033" ]

[ "HSV_GH" ]

[ 650 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-9609690", "R-HSA-9610379" ]

[ "REACTOME:R-HSA-9609690", "REACTOME:R-HSA-9610379" ]

2

[ "3m1c", "4xhj", "4xi5", "5vob", "5voc", "5vod", "5w0k", "6c5v", "7b7n", "7cze", "7czf", "7d5z", "7lbe", "7lbf", "7lbg", "7ram", "7t4q", "7t4r", "7t4s", "8tco", "9dix", "9diy" ]

22

[ "PUB00009448", "PUB00009449", "PUB00045942", "PUB00045943", "PUB00045944", "PUB00045945" ]

[ "9526546", "9267002", "17299053", "7769724", "3016991", "2552150" ]

[ "Identification and characterization of the guinea-pig cytomegalovirus glycoprotein H gene.", "Analysis of the biochemical properties of, and complex formation between, glycoproteins H and L of the gamma2 herpesvirus bovine herpesvirus-4.", "Herpes simplex virus type 1 mediates fusion through a hemifusion inter...

[ 1996, 1997, 2007, 1995, 1986, 1989 ]

6

[]

0

null

[ "Homo sapiens", "Orthoherpesviridae" ]

[ 1, 649 ]

2

[ "Homo sapiens" ]

[ 1 ]

1

true

Family

Herpesvirus glycoprotein H

Herpes_gH

8

IPR003494

3,494

SHS2 domain inserted in FtsA

SHS2_FtsA

Domain

24,841

false

FtsA is essential for bacterial cell division, and co-localises to the septal ring with FtsZ. The SHS2 domain, also known as subdomain 1C [ ], is inserted into the RNAseH fold of FtsA [ ], and is involved in protein-protein interaction [ ].

[ "GO:0005515", "GO:0051301" ]

[ "protein binding", "cell division" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "SMART" ]

[ "PF02491", "SM00842" ]

[ "SHS2_FTSA", "FtsA" ]

[ 18129, 24819 ]

2

[]

0

[ "1e4f", "1e4g", "3jc8", "3jc9", "3wqt", "3wqu", "3wt0", "4a2a", "4a2b", "5eou", "5eox", "5eoy", "5eq6", "7q6d", "7q6f", "7q6g", "7q6i" ]

17

[ "PUB00009447", "PUB00057445", "PUB00065857" ]

[ "9352931", "15281131", "22473211" ]

[ "Interactions between heterologous FtsA and FtsZ proteins at the FtsZ ring.", "The SHS2 module is a common structural theme in functionally diverse protein groups, like Rpb7p, FtsA, GyrI, and MTH1598/TM1083 superfamilies.", "FtsA forms actin-like protofilaments." ]

[ 1997, 2004, 2012 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 14, 24335, 47, 445 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

SHS2 domain inserted in FtsA

SHS2_FtsA

6

IPR003495

3,495

CobW/HypB/UreG, nucleotide-binding domain

CobW/HypB/UreG_nucleotide-bd

Domain

68,655

false

This domain is found in HypB, a hydrogenase expression/formation protein, and urease accessory protein UreG. Both these proteins contain a P-loop nucleotide binding motif [ , ]. HypB has GTPase activity and is a guanine nucleotide binding protein [ ]. UreG is a GTPase in charge of nucleotide hydrolysis required for act...

[]

0

[ "PFAM" ]

[ "PF02492" ]

[ "cobW" ]

[ 68655 ]

1

[ "GP" ]

[ "GenProp0899" ]

[ "GP:GenProp0899" ]

1

[ "1nij", "2hf8", "2hf9", "2wsm", "4hi0", "4ixm", "4ixn", "4lps", "5xkt" ]

9

[ "PUB00002187", "PUB00002230", "PUB00002310", "PUB00003878", "PUB00008140", "PUB00029084", "PUB00078797", "PUB00078798" ]

[ "1624427", "8423137", "9209019", "9140970", "1655697", "14696199", "24449932", "25846143" ]

[ "Klebsiella aerogenes urease gene cluster: sequence of ureD and demonstration that four accessory genes (ureD, ureE, ureF, and ureG) are involved in nickel metallocenter biosynthesis.", "The product of the hypB gene, which is required for nickel incorporation into hydrogenases, is a novel guanine nucleotide-bindi...

[ 1992, 1993, 1997, 1997, 1991, 2004, 2013, 2015 ]

8

[]

0

null

[ "Archaea", "Bacillus phage SP-15", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1586, 1, 53707, 12871, 490 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)...

[ 18, 2, 3, 33, 1, 3, 11, 10, 1, 2, 21 ]

11

true

Domain

CobW/HypB/UreG, nucleotide-binding domain

CobW/HypB/UreG_nucleotide-bd

1

IPR003496

3,496

ABA/WDS induced protein

ABA_WDS

Family

2,142

false

This is a family of plant proteins induced by water deficit stress (WDS) [ ], or abscisic acid (ABA) stress and ripening [ ]. The Ip3 cDNA clone is expressed at high levels in the roots, and is induced by ABA under WDS.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF02496", "PTHR33801" ]

[ "ABA_WDS", "" ]

[ 2142, 2038 ]

2

[]

0

[]

0

[ "PUB00009445", "PUB00009446" ]

[ "9426600", "7630961" ]

[ "Expression analysis of a gene family in loblolly pine (Pinus taeda L.) induced by water deficit stress.", "Pummelo fruit transcript homologous to ripening-induced genes." ]

[ 1997, 1995 ]

2

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 3, 2139 ]

2

[ "Oryza sativa subsp. japonica", "Zea mays" ]

[ 19, 32 ]

2

true

Family

ABA/WDS induced protein

ABA_WDS

6

IPR003497

3,497

BRO N-terminal domain

BRO_N_domain

Domain

13,504

false

The baculovirus Bro proteins are encoded by a multigene family. The typical Bro proteins that have been experimentally investigated are BroA, BroC and BroD from Bombyx mori uclear polyhedrosis virus (BmNV). They contain distinct amino- and carboxy-terminal domains (Bro-N and Bro-C, respectively) that are present indepe...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF02498", "PS51750", "SM01040" ]

[ "Bro-N", "BRO_N", "Bro-N" ]

[ 12361, 10783, 10592 ]

3

[]

0

[]

0

[ "PUB00010111" ]

[ "11897024" ]

[ "Extensive domain shuffling in transcription regulators of DNA viruses and implications for the origin of fungal APSES transcription factors." ]

[ 2002 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 77, 11126, 372, 1734, 195 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

BRO N-terminal domain

BRO_N_domain

1

IPR003498

3,498

Probable DNA packing protein, C-terminal

DNA_pack_C

Domain

818

false

This family includes proteins that are probably involved in DNA packing in Herpesviridae. This domain is found at the C terminus of the protein.

[ "GO:0051276" ]

[ "chromosome organization" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF02499" ]

[ "DNA_pack_C" ]

[ 818 ]

1

[ "REACTOME" ]

[ "R-HSA-9610379" ]

[ "REACTOME:R-HSA-9610379" ]

1

[ "2kn8", "3n4p", "3n4q", "4iox", "6ey7", "6m5r", "6m5s", "6m5t", "6m5u", "6m5v" ]

10

[]

0

[]

0

null

[ "Eumetazoa", "Herpesvirales" ]

[ 10, 808 ]

2

[ "Homo sapiens" ]

[ 1 ]

1

true

Domain

Probable DNA packing protein, C-terminal

DNA_pack_C

9

IPR003499

3,499

Probable DNA packing protein, N-terminal

DNA_pack_N

Domain

532

false

This family includes proteins that are probably involved in DNA packing in Herpesviridae. This domain is normally found at the N terminus of the protein.

[ "GO:0051276" ]

[ "chromosome organization" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF02500" ]

[ "DNA_pack_N" ]

[ 532 ]

1

[ "REACTOME" ]

[ "R-HSA-9610379" ]

[ "REACTOME:R-HSA-9610379" ]

1

[ "6m5r", "6m5s", "6m5u", "6m5v" ]

4

[]

0

[]

0

null

[ "Bacteria", "Bilateria", "Herpesvirales" ]

[ 2, 8, 522 ]

3

[ "Homo sapiens" ]

[ 1 ]

1

true

Domain

Probable DNA packing protein, N-terminal

DNA_pack_N

4

IPR003500

3,500

Sugar-phosphate isomerase, RpiB/LacA/LacB family

RpiB_LacA_LacB

Family

26,109

false

This entry represents the sugar isomerase enzymes ribose 5-phosphate isomerase B (RpiB), galactose isomerase subunit A (LacA) and galactose isomerase subunit B (LacB). Galactose-6-phosphate isomerase ( ) is a heteromultimeric protein consisting of subunits LacA and LacB, and catalyses the conversion of D-galactose 6-ph...

[ "GO:0016853", "GO:0005975" ]

[ "isomerase activity", "carbohydrate metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PIRSF", "PANTHER", "NCBIFAM" ]

[ "PF02502", "PIRSF005384", "PTHR30345", "TIGR00689" ]

[ "LacAB_rpiB", "RpiB_LacA_B", "", "rpiB_lacA_lacB" ]

[ 26030, 22347, 17738, 22480 ]

4

[ "EC", "EC", "GP", "GP", "GP" ]

[ "5.3.1", "5.3.1.26", "GenProp1294", "GenProp1438", "GenProp1463" ]

[ "EC:5.3.1", "EC:5.3.1.26", "GP:GenProp1294", "GP:GenProp1438", "GP:GenProp1463" ]

5

[ "1nn4", "1o1x", "1usl", "2bes", "2bet", "2ppw", "2vvo", "2vvp", "2vvq", "2vvr", "3c5y", "3he8", "3hee", "3k7o", "3k7p", "3k7s", "3k8c", "3m1p", "3ono", "3ph3", "3ph4", "3qd5", "3s5p", "3sdw", "3sgw", "4em8", "4lfk", "4lfl", "4lfm", "4lfn", "4u8e", "4u8f"...

37

[ "PUB00002200", "PUB00029142" ]

[ "1400164", "14499611" ]

[ "Nucleotide and deduced amino acid sequences of the lacR, lacABCD, and lacFE genes encoding the repressor, tagatose 6-phosphate gene cluster, and sugar-specific phosphotransferase system components of the lactose operon of Streptococcus mutans.", "The 2.2 A resolution structure of RpiB/AlsB from Escherichia coli ...

[ 1992, 2003 ]

2

[]

[ "IPR004783", "IPR004784", "IPR004785", "IPR011860", "IPR012100" ]

0

5

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 45, 23613, 1912, 5, 534 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 1, 1, 3, 3 ]

5

true

Family

Sugar-phosphate isomerase, RpiB/LacA/LacB family

RpiB_LacA_LacB

2

IPR003501

3,501

Phosphotransferase system, EIIB component, type 2/3

PTS_EIIB_2/3

Domain

48,203

false

The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIB PTS system cytoplasmic enzymes. T...

[ "GO:0008982", "GO:0009401" ]

[ "protein-N(PI)-phosphohistidine-sugar phosphotransferase activity", "phosphoenolpyruvate-dependent sugar phosphotransferase system" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF02302" ]

[ "PTS_IIB" ]

[ 48203 ]

1

[ "EC", "GP" ]

[ "2.7.1", "GenProp0119" ]

[ "EC:2.7.1", "GP:GenProp0119" ]

2

[ "1e2b", "1h9c", "1iib", "1tvm", "1vkr", "1vrv", "2few", "2kyr", "2l2q", "2m1z", "2r48", "2r4q", "2wwv", "2wy2", "3czc", "3nbm", "4mge", "4tn5", "5dle", "5gqs" ]

20

[]

0

[]

[ "IPR013011", "IPR013012" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 136, 47905, 27, 135 ]

4

[ "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica" ]

[ 12, 1 ]

2

true

Domain

Phosphotransferase system, EIIB component, type 2/3

PTS_EIIB_2/3

5

IPR003502

3,502

Interleukin-1 propeptide

IL-1_propep

Domain

921

false

The N-terminal of Interleukin-1 is approximately 115 amino acids long, it forms a propeptide that is cleaved off to release the active interleukin-1. This entry represents the propeptide. Interleukin-1 alpha and interleukin-1 beta (IL-1 alpha and IL-1 beta) are cytokines that participate in the regulation of immune res...

[ "GO:0005149", "GO:0006954", "GO:0006955" ]

[ "interleukin-1 receptor binding", "inflammatory response", "immune response" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "PFAM" ]

[ "PF02394" ]

[ "IL1_propep" ]

[ 921 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-448706", "R-BTA-5620971", "R-BTA-9020702", "R-HSA-2559582", "R-HSA-448706", "R-HSA-5620971", "R-HSA-5660668", "R-HSA-6783783", "R-HSA-6785807", "R-HSA-9020702", "R-HSA-9660826", "R-MMU-448706", "R-MMU-5620971", "R-MMU-5660668", "R-MMU-9020702", "R-RNO-448706", "R-RNO-5620971",...

[ "REACTOME:R-BTA-448706", "REACTOME:R-BTA-5620971", "REACTOME:R-BTA-9020702", "REACTOME:R-HSA-2559582", "REACTOME:R-HSA-448706", "REACTOME:R-HSA-5620971", "REACTOME:R-HSA-5660668", "REACTOME:R-HSA-6783783", "REACTOME:R-HSA-6785807", "REACTOME:R-HSA-9020702", "REACTOME:R-HSA-9660826", "REACTOME:...

23

[]

0

[ "PUB00003281", "PUB00004697", "PUB00007346", "PUB00007347", "PUB00007348", "PUB00007349", "PUB00007350" ]

[ "1738162", "2602367", "2969618", "8702856", "1833184", "1826022", "1339315" ]

[ "beta-Trefoil fold. Patterns of structure and sequence in the Kunitz inhibitors interleukins-1 beta and 1 alpha and fibroblast growth factors.", "Crystallographic refinement of interleukin 1 beta at 2.0 A resolution.", "cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily.", ...

[ 1992, 1989, 1988, 1996, 1991, 1991, 1992 ]

7

[]

0

null

[ "Euteleostomi" ]

[ 921 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 4, 10 ]

3

true

Domain

Interleukin-1 propeptide

IL-1_propep

3

IPR003504

3,504

Glial cell line-derived neurotrophic factor receptor alpha 2

GDNF_rcpt_a2

Family

713

false

Glial cell line-derived neurotrophic factor (GDNF) and its related factors neurturin (NTN), artemin (ART) and persephin (PSP), are members of the GDNF family of neurotrophic factors. They form a sub-group in the transforming growth factor-beta (TGF-beta) superfamily. These factors are involved in the promotion of neuro...

[ "GO:0038023" ]

[ "signaling receptor activity" ]

[ "molecular_function" ]

1

[ "PRINTS" ]

[ "PR01318" ]

[ "GDNFRALPHA2" ]

[ 713 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-419037", "R-HSA-5673001", "R-HSA-8853659", "R-MMU-5673001", "R-MMU-8853659" ]

[ "REACTOME:R-HSA-419037", "REACTOME:R-HSA-5673001", "REACTOME:R-HSA-8853659", "REACTOME:R-MMU-5673001", "REACTOME:R-MMU-8853659" ]

5

[ "5mr4", "6gl7", "6q2o", "6q2r" ]

4

[ "PUB00009432", "PUB00009436" ]

[ "10356294", "9177201" ]

[ "GDNF family neurotrophic factor signaling: four masters, one servant?", "Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins." ]

[ 1999, 1997 ]

2

[ "IPR017372" ]

[]

1

0

1

[ "Euteleostomi" ]

[ 713 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 3, 7 ]

3

true

Family

Glial cell line-derived neurotrophic factor receptor alpha 2

GDNF_rcpt_a2

2

IPR003505

3,505

Glial cell line-derived neurotrophic factor receptor, alpha 3

GDNF_rcpt_A3

Family

226

false

Glial cell line-derived neurotrophic factor (GDNF) and its related factors neurturin (NTN), artemin (ART) and persephin (PSP), are members of the GDNF family of neurotrophic factors. They form a sub-group in the transforming growth factor-beta (TGF-beta) superfamily. These factors are involved in the promotion of neuro...

[ "GO:0038023" ]

[ "signaling receptor activity" ]

[ "molecular_function" ]

1

[ "PRINTS" ]

[ "PR01319" ]

[ "GDNFRALPHA3" ]

[ 226 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5673001", "R-HSA-8853659", "R-MMU-5673001", "R-MMU-8853659" ]

[ "REACTOME:R-HSA-5673001", "REACTOME:R-HSA-8853659", "REACTOME:R-MMU-5673001", "REACTOME:R-MMU-8853659" ]

4

[ "2gh0", "6q2s" ]

2

[ "PUB00009432", "PUB00009434", "PUB00009437" ]

[ "10356294", "9576965", "9883723" ]

[ "GDNF family neurotrophic factor signaling: four masters, one servant?", "GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family.", "Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex." ]

[ 1999, 1998, 1998 ]

3

[ "IPR003438" ]

[]

1

0

1

[ "Eutheria" ]

[ 226 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 2, 3 ]

3

true

Family

Glial cell line-derived neurotrophic factor receptor, alpha 3

GDNF_rcpt_A3

8

IPR003506

3,506

Chlamydia cysteine-rich outer membrane protein 6

Chlam_OMP6

Family

83

false

Three cysteine-rich proteins (also believed to be lipoproteins) make up the extracellular matrix of the Chlamydial outer membrane [ ]. They are involved in the essential structural integrity of both the elementary body (EB) and recticulate body (RB) phase. As these bacteria lack the peptidoglycan layer common to most G...

[ "GO:0005201" ]

[ "extracellular matrix structural constituent" ]

[ "molecular_function" ]

1

[ "PFAM", "PRINTS" ]

[ "PF03504", "PR01336" ]

[ "Chlam_OMP6", "CHLAMIDIAOM6" ]

[ 69, 83 ]

2

[]

0

[]

0

[ "PUB00009430", "PUB00009438", "PUB00009439" ]

[ "2287277", "8477811", "10037605" ]

[ "Cysteine-rich outer membrane proteins of Chlamydia trachomatis display compensatory sequence changes between biovariants.", "An intermolecular mechanism of T cell help for the production of antibodies to the bacterial pathogen, Chlamydia trachomatis.", "Chlamydia infections and heart disease linked through ant...

[ 1990, 1993, 1999 ]

3

[]

0

null

[ "PVC group", "hydrothermal vent metagenome" ]

[ 82, 1 ]

2

[]

0

true

Family

Chlamydia cysteine-rich outer membrane protein 6

Chlam_OMP6

2

IPR003507

3,507

Peptidase family S66

S66_fam

Family

19,486

false

This entry includes proteins belonging to the MEROPS peptidase family S66, such as muramoyl-tetrapeptide carboxypeptidase and the microcin c7 self-immunity protein .

[]

0

[ "PIRSF", "PANTHER" ]

[ "PIRSF028757", "PTHR30237" ]

[ "LD-carboxypeptidase", "" ]

[ 16820, 19486 ]

2

[ "EC", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "3.4.16.-", "GenProp1242", "GenProp1623", "PWY-5706", "PWY-5707", "PWY-6470", "PWY-7614" ]

[ "EC:3.4.16.-", "GP:GenProp1242", "GP:GenProp1623", "METACYC:PWY-5706", "METACYC:PWY-5707", "METACYC:PWY-6470", "METACYC:PWY-7614" ]

7

[ "1zl0", "1zrs", "2aum", "2aun", "3g23", "3gjz", "3sr3", "3t5m", "3tla", "3tlb", "3tlc", "3tle", "3tlg", "3tly", "3tlz", "3tyx", "3u1b", "4e5s", "4e94", "4eys", "4h1h", "4iix", "4iiy", "4inj", "4jvo", "4mi1", "4mjx", "5f1y", "5f5x", "5f9m", "5fd8", "5jyb"...

37

[ "PUB00020065", "PUB00059308" ]

[ "10428950", "18535144" ]

[ "A defect in cell wall recycling triggers autolysis during the stationary growth phase of Escherichia coli.", "How bacteria consume their own exoskeletons (turnover and recycling of cell wall peptidoglycan)." ]

[ 1999, 2008 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 194, 18662, 469, 161 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Peptidase family S66

S66_fam

6

IPR003508

3,508

CIDE-N domain

CIDE-N_dom

Domain

5,565

false

The CIDE-N or CAD domain is a ~78 amino acid protein-protein interaction domain in the N-terminal part of Cell death-Inducing DFF45-like Effector (CIDE) proteins, involved in apoptosis. At the final stage of programmed cell death, chromosomal DNA is degraded into fragments by Caspase-activated DNase (CAD), also named D...

[ "GO:0006915" ]

[ "apoptotic process" ]

[ "biological_process" ]

1

[ "PFAM", "PROFILE", "SMART" ]

[ "PF02017", "PS51135", "SM00266" ]

[ "CIDE-N", "CIDE_N", "CAD" ]

[ 5519, 5429, 5300 ]

3

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "PDOC51135", "R-HSA-140342", "R-HSA-8963889", "R-HSA-8964572", "R-HSA-9841922", "R-HSA-9844594", "R-MMU-140342", "R-MMU-8964572", "R-RNO-140342", "R-RNO-8964572" ]

[ "PROSITEDOC:PDOC51135", "REACTOME:R-HSA-140342", "REACTOME:R-HSA-8963889", "REACTOME:R-HSA-8964572", "REACTOME:R-HSA-9841922", "REACTOME:R-HSA-9844594", "REACTOME:R-MMU-140342", "REACTOME:R-MMU-8964572", "REACTOME:R-RNO-140342", "REACTOME:R-RNO-8964572" ]

10

[ "1c9f", "1d4b", "1f2r", "1ibx", "1v0d", "2eel", "4d2k", "4ikg", "4mac", "5xpb", "5xpc", "7v6e" ]

12

[ "PUB00018564", "PUB00018565", "PUB00018566", "PUB00018567", "PUB00018568" ]

[ "15149602", "9564035", "10619428", "10764577", "11371636" ]

[ "Structural mechanism for inactivation and activation of CAD/DFF40 in the apoptotic pathway.", "CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor.", "Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in th...

[ 2004, 1998, 1999, 2000, 2001 ]

5

[]

[ "IPR032936" ]

0

1

0

[ "Baculoviridae", "Candidatus Brachybacterium intestinipullorum", "Opisthokonta" ]

[ 7, 1, 5557 ]

3

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 12, 17, 13, 26 ]

5

true

Domain

CIDE-N domain

CIDE-N_dom

7

IPR003509

3,509

UPF0102 protein YraN-like

UPF0102_YraN-like

Family

22,163

false

The proteins in this entry are functionally uncharacterised.

[]

0

[ "HAMAP", "PFAM", "PANTHER", "NCBIFAM" ]

[ "MF_00048", "PF02021", "PTHR34039", "TIGR00252" ]

[ "UPF0102", "UPF0102", "", "" ]

[ 21063, 22158, 21927, 11414 ]

4

[]

0

[ "3fov" ]

1

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 19, 21672, 15, 457 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

UPF0102 protein YraN-like

UPF0102_YraN-like

3

IPR003510

3,510

Fumarate reductase, subunit C

Fumarate_red_C

Family

2,093

false

Fumarate reductase is a membrane-bound flavoenzyme consisting of four subunits, A-D. A and B comprise the membrane-extrinsic catalytic domain and C and D link the catalytic centres to the electron-transport chain. This family consists of the 15kDa hydrophobic subunit C. Members of this subfamily are classified as Type ...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "HAMAP", "PFAM", "PIRSF", "CDD" ]

[ "MF_00708", "PF02300", "PIRSF000180", "cd00546" ]

[ "Fumarate_red_C", "Fumarate_red_C", "FrdC", "QFR_TypeD_subunitC" ]

[ 1549, 2093, 1815, 1592 ]

4

[ "GP", "GP", "GP", "GP", "GP", "GP" ]

[ "GenProp0756", "GenProp1143", "GenProp1267", "GenProp1391", "GenProp1537", "GenProp1672" ]

[ "GP:GenProp0756", "GP:GenProp1143", "GP:GenProp1267", "GP:GenProp1391", "GP:GenProp1537", "GP:GenProp1672" ]

6

[ "1kf6", "1kfy", "1l0v", "2b76", "3cir", "3p4p", "3p4q", "3p4r", "3p4s", "4kx6", "5vpn", "6awf" ]

12

[ "PUB00013184", "PUB00015147", "PUB00015643", "PUB00015715", "PUB00015792", "PUB00019585", "PUB00020385", "PUB00079565", "PUB00079566", "PUB00079567", "PUB00079568" ]

[ "11850430", "11803023", "11004459", "15078221", "9210286", "3308458", "10373108", "15654871", "15884941", "10486141", "11803024" ]

[ "Crystallographic studies of the Escherichia coli quinol-fumarate reductase with inhibitors bound to the quinol-binding site.", "Succinate dehydrogenase and fumarate reductase from Escherichia coli.", "Succinate: quinone oxidoreductases: new insights from X-ray crystal structures.", "Complex II from a structu...

[ 2002, 2002, 2000, 2004, 1997, 1987, 1999, 2005, 2005, 1999, 2002 ]

11

[]

0

null

[ "Anopheles maculatus", "Bacteria", "metagenomes" ]

[ 1, 2063, 29 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Fumarate reductase, subunit C

Fumarate_red_C

6

IPR003511

3,511

HORMA domain

HORMA_dom

Domain

13,133

false

The HORMA domain (for HOP1, REV7 and MAD2) is an about 180-240 amino acids region containing several conserved motifs. Whereas the MAD2 and the REV7 proteins are almost entirely made up of HORMA domains, HOP1 contains a HORMA domain in its N-terminal region and a Zn-finger domain, whose general arrangement of metal-che...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF02301", "PS50815" ]

[ "HORMA", "HORMA" ]

[ 12255, 12884 ]

2

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "PDOC50815", "R-DDI-110312", "R-DDI-141405", "R-DDI-141430", "R-DDI-174184", "R-DDI-176409", "R-DDI-179409", "R-DDI-5655862", "R-DME-110312", "R-DME-5655862", "R-DME-5656121", "R-DRE-5656121", "R-GGA-110312", "R-GGA-353299", "R-GGA-353473", "R-GGA-5655862", "R-GGA-5656121", "R-HSA-...

[ "PROSITEDOC:PDOC50815", "REACTOME:R-DDI-110312", "REACTOME:R-DDI-141405", "REACTOME:R-DDI-141430", "REACTOME:R-DDI-174184", "REACTOME:R-DDI-176409", "REACTOME:R-DDI-179409", "REACTOME:R-DDI-5655862", "REACTOME:R-DME-110312", "REACTOME:R-DME-5655862", "REACTOME:R-DME-5656121", "REACTOME:R-DRE-5...

61

[ "1duj", "1go4", "1klq", "1s2h", "2qyf", "2v64", "2vfx", "3abd", "3abe", "3gmh", "3vu7", "4aez", "4ext", "4fjo", "4gk0", "4gk5", "4trk", "4tzj", "4tzl", "4tzm", "4tzn", "4tzo", "4tzq", "4tzs", "5khu", "5lcw", "5o8k", "5xpt", "5xpu", "6bc8", "6bcd", "6bi7"...

58

[ "PUB00018278", "PUB00097380" ]

[ "9757827", "28887307" ]

[ "The HORMA domain: a common structural denominator in mitotic checkpoints, chromosome synapsis and DNA repair.", "Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment-maintaining phosphoprotein (CAMP)." ]

[ 1998, 2017 ]

2

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 3, 13130 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 21, 7, 6, 2, 14, 11, 3, 15, 13, 3, 3, 28 ]

12

true

Domain

HORMA domain

HORMA_dom

3

IPR003512

3,512

Bacteriophage M13, G5P, DNA-binding

Phage_M13_G5P_DNA-bd

Family

326

false

This entry is represented by the Bacteriophage M13, G5P, DNA-binding protein. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. G5P is the bacteriophage helix-destabilising protein, or single-stranded DNA binding protein, required for DNA synthesis. The protein b...

[ "GO:0003697", "GO:0006260" ]

[ "single-stranded DNA binding", "DNA replication" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF02303" ]

[ "Phage_DNA_bind" ]

[ 326 ]

1

[]

0

[ "1ae2", "1ae3", "1gkh", "1gvp", "1vqa", "1vqb", "1vqc", "1vqd", "1vqe", "1vqf", "1vqg", "1vqh", "1vqi", "1vqj", "1yha", "1yhb", "2gn5", "2gva", "2gvb", "8acz" ]

20

[]

0

[]

0

null

[ "Bacteria", "Inoviridae", "Panagrolaimus sp. ES5", "bioreactor metagenome" ]

[ 299, 25, 1, 1 ]

4

[]

0

true

Family

Bacteriophage M13, G5P, DNA-binding

Phage_M13_G5P_DNA-bd

9

IPR003513

3,513

Scaffold protein B

Phage_B

Family

122

false

This is a family of proteins from single-stranded DNA bacteriophages. Scaffold proteins B and D are required for procapsid formation. Sixty copies of the internal scaffold protein B are found in the procapsid [ ].

[ "GO:0019069" ]

[ "viral capsid assembly" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF02304" ]

[ "Phage_B" ]

[ 122 ]

1

[]

0

[ "1al0", "1cd3", "1m0f" ]

3

[ "PUB00007418" ]

[ "9305849" ]

[ "Structure of a viral procapsid with molecular scaffolding." ]

[ 1997 ]

1

[]

0

null

[ "Bacteria", "Bullavirinae", "Eukaryota" ]

[ 23, 77, 22 ]

3

[]

0

true

Family

Scaffold protein B

Phage_B

8

IPR003514

3,514

Microviridae F protein

Microviridae_protein_F

Family

1,844

false

This entry represents the Microviridae F protein family, including capsid protein F and capsid protein VP1. Capsid protein F is the major capsid component in single-stranded DNA bacteriophages. 60 copies of this protein are present in the virion [ ].

[ "GO:0005198" ]

[ "structural molecule activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF02305" ]

[ "Phage_F" ]

[ 1844 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[ "1al0", "1cd3", "1gff", "1kvp", "1m06", "1m0f", "1rb8", "2bpa", "8des", "9cgm", "9k3m", "9k3n" ]

12

[ "PUB00020089" ]

[ "8642594" ]

[ "Atomic structure of the degraded procapsid particle of the bacteriophage G4: induced structural changes in the presence of calcium ions and functional implications." ]

[ 1996 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanomicrobia", "Viruses", "organismal metagenomes" ]

[ 261, 111, 3, 1463, 6 ]

5

[]

0

true

Family

Microviridae F protein

Microviridae_protein_F

4

IPR003515

3,515

Major spike protein G

Spike_G

Family

268

false

This is a family of proteins from single-stranded DNA bacteriophages. The G protein is a major spike protein involved in attachment to the bacterial host cell. The virion is composed of sixty copies of each of the F, G and J proteins, and 12 copies of the H protein. There are twelve spikes formed by five G proteins, ea...

[ "GO:0044003" ]

[ "symbiont-mediated perturbation of host process" ]

[ "biological_process" ]

1

[ "PFAM", "PIRSF" ]

[ "PF02306", "PIRSF004159" ]

[ "Phage_G", "Spike_G" ]

[ 268, 247 ]

2

[]

0

[ "1al0", "1cd3", "1gff", "1m06", "1m0f", "1rb8", "2bpa", "9k3m", "9k3n" ]

9

[ "PUB00062408", "PUB00062409" ]

[ "10739948", "14553915" ]

[ "Characterization of the binding of spike H protein of bacteriophage phiX174 with receptor lipopolysaccharides.", "Different contributions of the outer and inner R-core residues of lipopolysaccharide to the recognition by spike H and G proteins of bacteriophage phiX174." ]

[ 2000, 2003 ]

2

[]

0

null

[ "Bacteria", "Bullavirinae", "Candidatus Argoarchaeum ethanivorans", "Eukaryota" ]

[ 150, 83, 1, 34 ]

4

[]

0

true

Family

Major spike protein G

Spike_G

8

IPR003516

3,516

Fanconi anaemia group A protein

FANCA

Family

1,534

false

This entry represents FANCA [ ]. Fanconi anemia (FA) is a human disorder characterised by cancer susceptibility and cellular sensitivity to DNA crosslinks and other damages. The FA complex repairs the interstrand cross-linking (ICL) lesions and coordinates activities of the downstream DNA repair pathway including nucle...

[ "GO:0036297", "GO:0043240" ]

[ "interstrand cross-link repair", "Fanconi anaemia nuclear complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PRINTS", "PANTHER" ]

[ "PR00826", "PTHR12047" ]

[ "FANCONIAGENE", "" ]

[ 861, 1534 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6783310", "R-HSA-9833482", "R-MMU-6783310", "R-MMU-9833482" ]

[ "REACTOME:R-HSA-6783310", "REACTOME:R-HSA-9833482", "REACTOME:R-MMU-6783310", "REACTOME:R-MMU-9833482" ]

4

[ "6lhs", "6lhu", "7kzp", "7kzq", "7kzr", "7kzs", "7kzt", "7kzv" ]

8

[ "PUB00054178", "PUB00089968" ]

[ "20347428", "29017571" ]

[ "A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability.", "DNA damage response and cancer therapeutics through the lens of the Fanconi Anemia DNA repair pathway." ]

[ 2010, 2017 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1534 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 29, 6, 6 ]

4

true

Family

Fanconi anaemia group A protein

FANCA

8

IPR003517

3,517

Cysteine-rich outer membrane protein 3, Chlamydia

Cys-rich_OMP3_Chlamydia

Family

34

false

Three cysteine-rich proteins (also believed to be lipoproteins) make up the extracellular matrix of the Chlamydial outer membrane [ ]. They are involved in the essential structural integrity of both the elementary body (EB) and recticulate body (RB) phase. As these bacteria lack the peptidoglycan layer common to most G...

[ "GO:0005201" ]

[ "extracellular matrix structural constituent" ]

[ "molecular_function" ]

1

[ "PFAM", "PRINTS" ]

[ "PF03503", "PR01335" ]

[ "Chlam_OMP3", "CHLAMIDIAOM3" ]

[ 34, 32 ]

2

[]

0

[]

0

[ "PUB00009430", "PUB00009438", "PUB00009439" ]

[ "2287277", "8477811", "10037605" ]

[ "Cysteine-rich outer membrane proteins of Chlamydia trachomatis display compensatory sequence changes between biovariants.", "An intermolecular mechanism of T cell help for the production of antibodies to the bacterial pathogen, Chlamydia trachomatis.", "Chlamydia infections and heart disease linked through ant...

[ 1990, 1993, 1999 ]

3

[]

0

null

[ "Chlamydia" ]

[ 34 ]

1

[]

0

true

Family

Cysteine-rich outer membrane protein 3, Chlamydia

Cys-rich_OMP3_Chlamydia

5

IPR003518

3,518

Salmonella plasmid virulence SpvA

Sal_SpvA

Family

182

false

Salmonella typhimurium contains a 90kb plasmid that is associated with virulence. This plasmid encodes at least 6 genes needed by the bacterium for invading host macrophages during infection. These include the 70kDa mkaA protein [ ], a recognised virulence factor, and more recently described, four spv genes under the c...

[]

0

[ "PRINTS" ]

[ "PR01340" ]

[ "SALSPVAPROT" ]

[ 182 ]

1

[]

0

[]

0

[ "PUB00008066", "PUB00008067", "PUB00008068", "PUB00009441" ]

[ "2164511", "1657882", "8483415", "2696057" ]

[ "Genetic and DNA sequence analysis of the Salmonella typhimurium virulence plasmid gene encoding the 28,000-molecular-weight protein.", "The Salmonella typhimurium virulence plasmid encodes a positive regulator of a plasmid-encoded virulence gene.", "Molecular analysis of spv virulence genes of the Salmonella v...

[ 1990, 1991, 1993, 1989 ]

4

[ "IPR018003" ]

[]

1

0

1

[ "Pseudomonadota" ]

[ 182 ]

1

[]

0

true

Family

Salmonella plasmid virulence SpvA

Sal_SpvA

1

IPR003519

3,519

OspF/SpvC

Family

332

false

This entry includes the virulence protein SpvC and the phosphothreonine lyase OspF. The spv region of the Salmonella virulence plasmids consists of five genes located on an 8-kb fragment, shown to be essential for virulence in mice [ ]. SpvC (also known as mkfA and VirA [ ]) is part of this gene cluster and is utilised...

[]

0

[ "PFAM", "PRINTS" ]

[ "PF03536", "PR01342" ]

[ "VRP3", "SALVRPPROT" ]

[ 332, 219 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "4.2.3.-", "PWY-3041", "PWY-5197", "PWY-5414", "PWY-5725", "PWY-6160", "PWY-6254", "PWY-6257", "PWY-6258", "PWY-6275", "PWY-6653", "PWY-7721" ]

[ "EC:4.2.3.-", "METACYC:PWY-3041", "METACYC:PWY-5197", "METACYC:PWY-5414", "METACYC:PWY-5725", "METACYC:PWY-6160", "METACYC:PWY-6254", "METACYC:PWY-6257", "METACYC:PWY-6258", "METACYC:PWY-6275", "METACYC:PWY-6653", "METACYC:PWY-7721" ]

12

[ "2p1w", "2q8y", "2z8m", "2z8n", "2z8o", "2z8p", "3bo6", "3i0u", "4h43", "4hah" ]

10

[ "PUB00064454", "PUB00064455", "PUB00064456", "PUB00064481", "PUB00064482" ]

[ "17159983", "17305427", "17303758", "1400193", "1378053" ]

[ "An injected bacterial effector targets chromatin access for transcription factor NF-kappaB to alter transcription of host genes involved in immune responses.", "Yeast functional genomic screens lead to identification of a role for a bacterial effector in innate immunity regulation.", "The phosphothreonine lyas...

[ 2007, 2007, 2007, 1992, 1992 ]

5

[]

0

null

[ "Pseudomonadota", "invertebrate metagenome" ]

[ 331, 1 ]

2

[]

0

true

Family

OspF/SpvC

8

IPR003520

3,520

Salmonella/Shigella invasion protein E

Invas_InvE

Family

770

false

Secretion of virulence factors in Gram-negative bacteria involves transportation of the protein across two membranes to reach the cell exterior. There have been four secretion systems described in sequence similarities in plant pathogens like Ralstonia and Erwinia [ ]. The type III secretion system is of great interest...

[ "GO:0009306" ]

[ "protein secretion" ]

[ "biological_process" ]

1

[ "PRINTS" ]

[ "PR01344" ]

[ "INVEPROTEIN" ]

[ 770 ]

1

[]

0

[ "2vix", "2vj4", "2vj5" ]

3

[ "PUB00007583", "PUB00007897", "PUB00007898" ]

[ "10564516", "8969244", "10334981" ]

[ "Flagellar proteins and type III-exported virulence factors are the predominant proteins secreted into the culture media of Salmonella typhimurium.", "Molecular mechanisms of bacterial virulence: type III secretion and pathogenicity islands.", "Type III secretion machines: bacterial devices for protein delivery...

[ 1999, 1996, 1999 ]

3

[]

0

null

[ "Bacteria", "human gut metagenome" ]

[ 768, 2 ]

2

[]

0

true

Family

Salmonella/Shigella invasion protein E

Invas_InvE

2

IPR003521

3,521

ICln

Family

2,346

false

ICln, known as methylosome subunit pICln or chloride conductance regulatory protein ICln, owes these different names to its function in multiple regulatory pathways [ ] as different as ion permeation, ribonucleoprotein biosynthesis and cytoskeletal organisation [ ]. ICln can be identified both in the cytosol and in the...

[ "GO:0000387", "GO:0006821", "GO:0006884", "GO:0005829", "GO:0005886", "GO:0034709", "GO:0034715" ]

[ "spliceosomal snRNP assembly", "chloride transport", "cell volume homeostasis", "cytosol", "plasma membrane", "methylosome", "pICln-Sm protein complex" ]

[ "biological_process", "biological_process", "biological_process", "cellular_component", "cellular_component", "cellular_component", "cellular_component" ]

7

[ "PRINTS" ]

[ "PR01348" ]

[ "ICLNCHANNEL" ]

[ 2346 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-191859", "R-MMU-191859", "R-RNO-191859" ]

[ "REACTOME:R-HSA-191859", "REACTOME:R-MMU-191859", "REACTOME:R-RNO-191859" ]

3

[ "1zyi", "4f7u", "4v98", "8g1u", "9e3a", "9e3b" ]

6

[ "PUB00065020", "PUB00066801", "PUB00069468", "PUB00069473", "PUB00069474", "PUB00070162", "PUB00070163", "PUB00070164", "PUB00070165", "PUB00070166", "PUB00070167" ]

[ "23333303", "10330151", "24298023", "19520849", "11747828", "16734741", "9556550", "20573047", "15760659", "17138647", "19471107" ]

[ "Structural Basis of Assembly Chaperone- Mediated snRNP Formation.", "pICln inhibits snRNP biogenesis by binding core spliceosomal proteins.", "Characterization and in vivo functional analysis of the Schizosaccharomyces pombe ICLN gene.", "Role of pICLn in methylation of Sm proteins by PRMT5.", "Methylation...

[ 2013, 1999, 2013, 2009, 2001, 2006, 1998, 2010, 2005, 2007, 2009 ]

11

[ "IPR039924" ]

[]

1

0

1

[ "Eukaryota" ]

[ 2346 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 3, 2, 1, 2, 4, 3, 4, 3, 11 ]

9

true

Family

ICln

5

IPR003522

3,522

Type III secretion system outer membrane pore YscC/HrcC

T3SS_OM_pore_YscC

Family

3,344

false

Secretion of virulence factors in Gram-negative bacteria involves transportation of the protein across two membranes to reach the cell exterior. There have been four secretion systems described in animal enteropathogens such as Salmonella and Yersinia, with further sequence similarities in plant pathogens like Ralstoni...

[ "GO:0009306" ]

[ "protein secretion" ]

[ "biological_process" ]

1

[ "HAMAP", "PRINTS", "NCBIFAM" ]

[ "MF_02219", "PR01337", "TIGR02516" ]

[ "Type_III_secretin", "TYPE3OMGPROT", "type_III_yscC" ]

[ 2974, 3334, 3229 ]

3

[ "GP" ]

[ "GenProp0052" ]

[ "GP:GenProp0052" ]

1

[ "5tcq", "5tcr", "6dv3", "6dv6", "6pee", "6pem", "6pep", "6q14", "6q15", "6q16", "6rwk", "7ah9", "7ahi", "8axk", "8axl", "8axn" ]

16

[ "PUB00007583", "PUB00007701", "PUB00007897", "PUB00007898", "PUB00089534", "PUB00097873", "PUB00106886" ]

[ "10564516", "8733226", "8969244", "10334981", "24207124", "30242280", "31427728" ]

[ "Flagellar proteins and type III-exported virulence factors are the predominant proteins secreted into the culture media of Salmonella typhimurium.", "Molecular genetic bases of Salmonella entry into host cells.", "Molecular mechanisms of bacterial virulence: type III secretion and pathogenicity islands.", "T...

[ 1999, 1996, 1996, 1999, 2013, 2018, 2019 ]

7

[]

0

null

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 3333, 3, 8 ]

3

[]

0

true

Family

Type III secretion system outer membrane pore YscC/HrcC

T3SS_OM_pore_YscC

2

IPR003523

3,523

Transcription factor COE

Transcription_factor_COE

Family

8,456

false

The independent cloning of rodent EBF/Olf-1 and Drosophila melanogaster Collier has defined a family of transcription factors, the Collier or COE family [ ]. COE proteins have various functions in different organisms. In mouse, COE1 has a role in B-cell differentiation, and could also perform a role in neuronal differe...

[ "GO:0003677", "GO:0006355" ]

[ "DNA binding", "regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "PANTHER" ]

[ "PTHR10747" ]

[ "" ]

[ 8456 ]

1

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME" ]

[ "PDOC01044", "R-HSA-381340", "R-HSA-9752946", "R-HSA-9844594" ]

[ "PROSITEDOC:PDOC01044", "REACTOME:R-HSA-381340", "REACTOME:R-HSA-9752946", "REACTOME:R-HSA-9844594" ]

4

[ "3lyr", "3mln", "3mlo", "3mlp", "3mqi", "3muj", "3n50" ]

7

[ "PUB00006682" ]

[ "10477305" ]

[ "Head versus trunk patterning in the Drosophila embryo; collier requirement for formation of the intercalary segment." ]

[ 1999 ]

1

[]

0

null

[ "Bacteria", "Opisthokonta" ]

[ 4, 8452 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 77, 6, 18, 19, 26 ]

6

true

Family

Transcription factor COE

Transcription_factor_COE

1

IPR003524

3,524

Phospho-N-acetylmuramoyl-pentapeptide transferase

PNAcMuramoyl-5peptid_Trfase

Family

25,412

false

Phospho-N-acetylmuramoyl-pentapeptide-transferase ( ) (MraY) is a bacterial enzyme responsible for the formation of the first lipid intermediate of the cell wall peptidoglycan synthesis [ ]. It catalyses the formation of undecaprenyl-pyrophosphoryl-N-acetylmuramoyl-pentapeptide from UDP-MurNAc-pentapeptide and undecapr...

[ "GO:0008963", "GO:0016020" ]

[ "phospho-N-acetylmuramoyl-pentapeptide-transferase activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "HAMAP", "NCBIFAM", "CDD" ]

[ "MF_00038", "TIGR00445", "cd06852" ]

[ "MraY", "mraY", "GT_MraY" ]

[ 24610, 24525, 25238 ]

3

[ "CAZY", "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "PROSITEDOC" ]

[ "GT4", "2.7.8.13", "GenProp1480", "PWY-5265", "PWY-6385", "PWY-6470", "PWY-6471", "PDOC01046" ]

[ "CAZY:GT4", "EC:2.7.8.13", "GP:GenProp1480", "METACYC:PWY-5265", "METACYC:PWY-6385", "METACYC:PWY-6470", "METACYC:PWY-6471", "PROSITEDOC:PDOC01046" ]

8

[ "4j72", "5ckr", "5jnq", "6oyh", "6oyz", "6oz6", "8cxr", "8g01", "8g02", "8tlu", "9b70", "9b71" ]

12

[ "PUB00006616" ]

[ "10564498" ]

[ "Topological analysis of the MraY protein catalysing the first membrane step of peptidoglycan synthesis." ]

[ 1999 ]

1

[ "IPR000715" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Siphoviridae sp. ctBLh2", "unclassified sequences" ]

[ 24337, 557, 3, 1, 514 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 1, 1, 1 ]

4

true

Family

Phospho-N-acetylmuramoyl-pentapeptide transferase

PNAcMuramoyl-5peptid_Trfase

6

IPR003526

3,526

2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

MECDP_synthase

Domain

22,473

false

IspF is a MECDP (2-C-methyl-D-erythritol 2,4-cyclodiphosphate) synthetase, also known as YgbB. It is an enzyme in the non-mevalonate pathway of isoprenoid synthesis. Isoprenoids are essential in all organisms, and can also be synthesized through the mevalonate pathway. The non-mevolante route is used by many bacteria a...

[ "GO:0008685", "GO:0016114" ]

[ "2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity", "terpenoid biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PFAM", "PANTHER", "NCBIFAM", "CDD" ]

[ "MF_00107", "PF02542", "PTHR43181", "TIGR00151", "cd00554" ]

[ "IspF", "YgbB", "", "ispF", "MECDP_synthase" ]

[ 21867, 22468, 21815, 21958, 22081 ]

5

[ "EC", "GP", "GP", "METACYC", "PROSITEDOC" ]

[ "4.6.1.12", "GenProp0048", "GenProp1295", "PWY-7560", "PDOC01048" ]

[ "EC:4.6.1.12", "GP:GenProp0048", "GP:GenProp1295", "METACYC:PWY-7560", "PROSITEDOC:PDOC01048" ]

5

[ "1gx1", "1h47", "1h48", "1iv1", "1iv2", "1iv3", "1iv4", "1jn1", "1jy8", "1knj", "1knk", "1t0a", "1u3l", "1u3p", "1u40", "1u43", "1vh8", "1vha", "1w55", "1w57", "1yqn", "2amt", "2gzl", "2pmp", "2uzh", "3b6n", "3elc", "3eor", "3ern", "3esj", "3f0d", "3f0e"...

73

[ "PUB00021869", "PUB00056865" ]

[ "12499535", "15233799" ]

[ "Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis.", "Biosynthesis of isoprenoids: a bifunctional IspDF enzyme from Campylobacter jejuni." ]

[ 2003, 2004 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 4, 20766, 1152, 551 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 1, 2, 10 ]

4

true

Domain

2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

MECDP_synthase

1

IPR003527

3,527

Mitogen-activated protein (MAP) kinase, conserved site

MAP_kinase_CS

Conserved_site

37,337

false

Eukaryotic serine-threonine mitogen-activated protein (MAP) kinases are key regulators of cellular signal transduction systems and are conserved from Saccharomyces cerevisiae (Baker's yeast) to human beings. MAPK pathways are signalling cascades differentially regulated by growth factors, mitogens, hormones and stress ...

[ "GO:0004707", "GO:0005524", "GO:0006468" ]

[ "MAP kinase activity", "ATP binding", "protein phosphorylation" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PROSITE" ]

[ "PS01351" ]

[ "MAPK" ]

[ 37337 ]

1

[ "EC", "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.7.11.24", "PDOC01049", "R-BTA-111995", "R-BTA-112409", "R-BTA-112411", "R-BTA-1181150", "R-BTA-1295596", "R-BTA-1502540", "R-BTA-162658", "R-BTA-170968", "R-BTA-198753", "R-BTA-198765", "R-BTA-202670", "R-BTA-2029482", "R-BTA-2173795", "R-BTA-2173796", "R-BTA-2559580", "R-BTA-25...

[ "EC:2.7.11.24", "PROSITEDOC:PDOC01049", "REACTOME:R-BTA-111995", "REACTOME:R-BTA-112409", "REACTOME:R-BTA-112411", "REACTOME:R-BTA-1181150", "REACTOME:R-BTA-1295596", "REACTOME:R-BTA-1502540", "REACTOME:R-BTA-162658", "REACTOME:R-BTA-170968", "REACTOME:R-BTA-198753", "REACTOME:R-BTA-198765", ...

491

[ "1a9u", "1bl6", "1bl7", "1bmk", "1cm8", "1di9", "1gol", "1ian", "1jnk", "1kv1", "1kv2", "1lew", "1lez", "1m7q", "1ouk", "1ouy", "1ove", "1oz1", "1pme", "1pmn", "1pmu", "1pmv", "1r39", "1r3c", "1tvo", "1ukh", "1uki", "1w7h", "1w82", "1w83", "1w84", "1wbn"...

776

[ "PUB00005115", "PUB00007544", "PUB00007545", "PUB00007546", "PUB00007547", "PUB00015362", "PUB00020114", "PUB00034898", "PUB00034899" ]

[ "3291115", "11242034", "11057833", "8607979", "8910361", "12368087", "12471243", "15078142", "15320712" ]

[ "The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.", "Mammalian MAP kinase signalling cascades.", "Mitogen-activated protein (MAP] kinase pathways in plants: versatile signaling tools.", "Dynamics and organization of MAP kinase signal pathways.", "Crystal structur...

[ 1988, 2001, 2001, 1995, 1996, 2002, 2002, 2004, 2004 ]

9

[]

0

null

[ "Bacteria", "Eukaryota", "Sylvanvirus sp." ]

[ 10, 37325, 2 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 78, 13, 92, 15, 68, 47, 3, 37, 55, 4, 3, 116 ]

12

true

Conserved_site

Mitogen-activated protein (MAP) kinase, conserved site

MAP_kinase_CS

3

IPR003528

3,528

Long hematopoietin receptor, single chain, conserved site

Long_hematopoietin_rcpt_CS

Conserved_site

2,463

false

A number of receptors for lymphokines, hematopoietic growth factors and growth hormone-related molecules have been found to share a common binding domain. These receptors are designated as hematopoietin receptors [ ] and the corresponding ligands as hematopoietins. Further, hematopoietins have been subdivided into two ...

[ "GO:0004896", "GO:0016020" ]

[ "cytokine receptor activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PROSITE" ]

[ "PS01352" ]

[ "HEMATOPO_REC_L_F1" ]

[ 2463 ]

1

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "PDOC01050", "R-HSA-1170546", "R-HSA-76009", "R-HSA-9006335", "R-HSA-9027276", "R-HSA-9027277", "R-HSA-9027283", "R-HSA-9027284", "R-HSA-982772", "R-MMU-1170546", "R-MMU-9006335", "R-MMU-9027276", "R-MMU-9027284", "R-MMU-982772", "R-RNO-1170546", "R-RNO-9006335", "R-RNO-9027276", "...

[ "PROSITEDOC:PDOC01050", "REACTOME:R-HSA-1170546", "REACTOME:R-HSA-76009", "REACTOME:R-HSA-9006335", "REACTOME:R-HSA-9027276", "REACTOME:R-HSA-9027277", "REACTOME:R-HSA-9027283", "REACTOME:R-HSA-9027284", "REACTOME:R-HSA-982772", "REACTOME:R-MMU-1170546", "REACTOME:R-MMU-9006335", "REACTOME:R-M...

24

[ "1a22", "1axi", "1bp3", "1cn4", "1eba", "1ebp", "1eer", "1ern", "1f6f", "1hwg", "1hwh", "1kf9", "2aew", "2jix", "2lfg", "3d48", "3ew3", "3hhr", "3mzg", "3n06", "3n0p", "3ncb", "3ncc", "3nce", "3ncf", "3npz", "4i18", "4y5v", "4y5x", "4y5y", "6moe", "6mof"...

43

[ "PUB00006639", "PUB00006640" ]

[ "1549776", "1400369" ]

[ "Human growth hormone and extracellular domain of its receptor: crystal structure of the complex.", "The interleukin-4-related lymphokines and their binding to hematopoietin receptors." ]

[ 1992, 1992 ]

2

[]

0

null

[ "Chordata", "Homoserinimonas aerilata" ]

[ 2462, 1 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 11, 18, 21 ]

4

true

Conserved_site

Long hematopoietin receptor, single chain, conserved site

Long_hematopoietin_rcpt_CS

4

IPR003529

3,529

Long hematopoietin receptor, Gp130 family 2, conserved site

Hematopoietin_rcpt_Gp130_CS

Conserved_site

4,853

false

A number of receptors for lymphokines, hematopoietic growth factors and growth hormone-related molecules have been found to share a common binding domain. These receptors are designated as hematopoietin receptors [ ] and the corresponding ligands as hematopoietins. Further, hematopoietins have been subdivided into two ...

[ "GO:0004896", "GO:0016020" ]

[ "cytokine receptor activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PROSITE" ]

[ "PS01353" ]

[ "HEMATOPO_REC_L_F2" ]

[ 4853 ]

1

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "PDOC01051", "R-CFA-6788467", "R-HSA-1059683", "R-HSA-110056", "R-HSA-112411", "R-HSA-2586552", "R-HSA-449836", "R-HSA-6788467", "R-HSA-8939247", "R-HSA-8984722", "R-HSA-9020591", "R-HSA-9020933", "R-HSA-9020956", "R-HSA-9616222", "R-HSA-9674555", "R-HSA-9705462", "R-MMU-1059683", ...

[ "PROSITEDOC:PDOC01051", "REACTOME:R-CFA-6788467", "REACTOME:R-HSA-1059683", "REACTOME:R-HSA-110056", "REACTOME:R-HSA-112411", "REACTOME:R-HSA-2586552", "REACTOME:R-HSA-449836", "REACTOME:R-HSA-6788467", "REACTOME:R-HSA-8939247", "REACTOME:R-HSA-8984722", "REACTOME:R-HSA-9020591", "REACTOME:R-H...

29

[ "3l5h", "3l5i", "3l5j", "8av2", "8avb", "8avc", "8avd", "8ave", "8avf", "8avo", "8b7q", "8c7m", "8d6a", "8d74", "8d7r", "8d82", "8d85", "8dh8", "8dh9", "8dha", "8dpt", "8odx", "8odz", "8oe0", "8oe4", "8pb1", "8qy4", "8qy5", "8qy6", "8v29", "8v2a", "8v2b"...

36

[ "PUB00006640", "PUB00006644", "PUB00006664", "PUB00006665" ]

[ "1400369", "8293462", "8943050", "8999038" ]

[ "The interleukin-4-related lymphokines and their binding to hematopoietin receptors.", "Cytokine signal transduction.", "A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits.", "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative si...

[ 1992, 1994, 1996, 1996 ]

4

[]

0

null

[ "Bacillati", "Eukaryota" ]

[ 8, 4845 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 3, 26, 18, 26 ]

5

true

Conserved_site

Long hematopoietin receptor, Gp130 family 2, conserved site

Hematopoietin_rcpt_Gp130_CS

2

IPR003530

3,530

Long hematopoietin receptor, soluble alpha chain, conserved site

Hematopoietin_rcpt_L_F3_CS

Conserved_site

3,363

false

A number of receptors for lymphokines, hematopoietic growth factors and growth hormone-related molecules have been found to share a common binding domain. These receptors are designated as hematopoietin receptors [ ] and the corresponding ligands as hematopoietins. Further, hematopoietins have been subdivided into two ...

[ "GO:0004896", "GO:0016020" ]

[ "cytokine receptor activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PROSITE" ]

[ "PS01354" ]

[ "HEMATOPO_REC_L_F3" ]

[ 3363 ]

1

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "PDOC01052", "R-CFA-6788467", "R-HSA-1059683", "R-HSA-110056", "R-HSA-112411", "R-HSA-6783783", "R-HSA-6785807", "R-HSA-6788467", "R-HSA-8984722", "R-HSA-9020591", "R-HSA-9020933", "R-HSA-9020956", "R-HSA-9616222", "R-HSA-9679191", "R-MMU-1059683", "R-MMU-110056", "R-MMU-112411", "...

[ "PROSITEDOC:PDOC01052", "REACTOME:R-CFA-6788467", "REACTOME:R-HSA-1059683", "REACTOME:R-HSA-110056", "REACTOME:R-HSA-112411", "REACTOME:R-HSA-6783783", "REACTOME:R-HSA-6785807", "REACTOME:R-HSA-6788467", "REACTOME:R-HSA-8984722", "REACTOME:R-HSA-9020591", "REACTOME:R-HSA-9020933", "REACTOME:R-...

28

[ "1f42", "1f45", "1n26", "1p9m", "1uc6", "2arw", "3d85", "3d87", "3duh", "3hmx", "3qwr", "4grw", "5fuc", "5mj3", "5mj4", "5mxa", "5mzv", "5njd", "6o4p", "6sff", "6smc", "6sp3", "6uib", "6wdq", "7dc8", "7pur", "7r3n", "7u7n", "7z0l", "7zg0", "7zxk", "8cr5"...

56

[ "PUB00006635", "PUB00006640", "PUB00006644" ]

[ "2070420", "1400369", "8293462" ]

[ "Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor.", "The interleukin-4-related lymphokines and their binding to hematopoietin receptors.", "Cytokine signal transduction." ]

[ 1991, 1992, 1994 ]

3

[]

0

null

[ "Vertebrata" ]

[ 3363 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 13, 19, 15, 15 ]

4

true

Conserved_site

Long hematopoietin receptor, soluble alpha chain, conserved site

Hematopoietin_rcpt_L_F3_CS

3

IPR003531

3,531

Short hematopoietin receptor, family 1, conserved site

Hempt_rcpt_S_F1_CS

Conserved_site

5,130

false

A number of receptors for lymphokines, hematopoietic growth factors and growth hormone-related molecules have been found to share a common binding domain. These receptors are designated as hematopoietin receptors [ ] and the corresponding ligands as hematopoietins. Further, hematopoietins have been subdivided into two ...

[ "GO:0004896", "GO:0016020" ]

[ "cytokine receptor activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PROSITE" ]

[ "PS01355" ]

[ "HEMATOPO_REC_S_F1" ]

[ 5130 ]

1

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "PDOC01053", "R-BTA-1266695", "R-BTA-5673001", "R-BTA-6785807", "R-BTA-8983432", "R-BTA-8985947", "R-BTA-9020558", "R-BTA-9020958", "R-BTA-912526", "R-HSA-1266695", "R-HSA-2586552", "R-HSA-512988", "R-HSA-5673001", "R-HSA-5683826", "R-HSA-5688849", "R-HSA-5688890", "R-HSA-6785807", ...

[ "PROSITEDOC:PDOC01053", "REACTOME:R-BTA-1266695", "REACTOME:R-BTA-5673001", "REACTOME:R-BTA-6785807", "REACTOME:R-BTA-8983432", "REACTOME:R-BTA-8985947", "REACTOME:R-BTA-9020558", "REACTOME:R-BTA-9020958", "REACTOME:R-BTA-912526", "REACTOME:R-HSA-1266695", "REACTOME:R-HSA-2586552", "REACTOME:R...

41

[ "1c8p", "1egj", "1gh7", "1iar", "2b5i", "2erj", "2gys", "3bpl", "3bpn", "3bpo", "3di2", "3di3", "3qaz", "3qb7", "3tgx", "3up1", "4gs7", "4nkq", "4nn5", "4nn6", "4nn7", "4nzd", "4qqv", "5dwu", "5e4e", "5j11", "5j12", "5m5e", "6dg5", "6nmy", "6oel", "6p50"...

57

[ "PUB00006637", "PUB00006640", "PUB00006651", "PUB00006657" ]

[ "1913811", "1400369", "7946053", "8552669" ]

[ "Subunit promiscuity among hemopoietic growth factor receptors.", "The interleukin-4-related lymphokines and their binding to hematopoietin receptors.", "The defective gene in X-linked severe combined immunodeficiency encodes a shared interleukin receptor subunit: implications for cytokine pleiotropy and redund...

[ 1991, 1992, 1994, 1996 ]

4

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 5, 5125 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 23, 35, 47, 43 ]

4

true

Conserved_site

Short hematopoietin receptor, family 1, conserved site

Hempt_rcpt_S_F1_CS

9

IPR003532

3,532

Short hematopoietin receptor, family 2, conserved site

Short_hematopoietin_rcpt_2_CS

Conserved_site

3,191

false

A number of receptors for lymphokines, hematopoietic growth factors and growth hormone-related molecules have been found to share a common binding domain. These receptors are designated as hematopoietin receptors [ ] and the corresponding ligands as hematopoietins. Further, hematopoietins have been subdivided into two ...

[ "GO:0004896", "GO:0016020" ]

[ "cytokine receptor activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PROSITE" ]

[ "PS01356" ]

[ "HEMATOPO_REC_S_F2" ]

[ 3191 ]

1

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "PDOC01054", "R-CFA-6785807", "R-HSA-512988", "R-HSA-5673001", "R-HSA-5683826", "R-HSA-5688849", "R-HSA-5688890", "R-HSA-6785807", "R-HSA-912526", "R-MMU-512988", "R-MMU-5673001", "R-MMU-6785807", "R-MMU-912526", "R-RNO-6785807" ]

[ "PROSITEDOC:PDOC01054", "REACTOME:R-CFA-6785807", "REACTOME:R-HSA-512988", "REACTOME:R-HSA-5673001", "REACTOME:R-HSA-5683826", "REACTOME:R-HSA-5688849", "REACTOME:R-HSA-5688890", "REACTOME:R-HSA-6785807", "REACTOME:R-HSA-912526", "REACTOME:R-MMU-512988", "REACTOME:R-MMU-5673001", "REACTOME:R-M...

14

[ "3bpn", "3bpo", "3lb6", "3qt2", "3va2", "4jzj", "4nkq", "4rs1", "5e4e", "5uv8", "5uwc", "6h41", "6nmy", "8tld" ]

14

[ "PUB00006637", "PUB00006640", "PUB00006657" ]

[ "1913811", "1400369", "8552669" ]

[ "Subunit promiscuity among hemopoietic growth factor receptors.", "The interleukin-4-related lymphokines and their binding to hematopoietin receptors.", "Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor." ]

[ 1991, 1992, 1996 ]

3

[]

0

null

[ "Opisthokonta" ]

[ 3191 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 23, 13, 17 ]

3

true

Conserved_site

Short hematopoietin receptor, family 2, conserved site

Short_hematopoietin_rcpt_2_CS

2

IPR003533

3,533

Doublecortin domain

Doublecortin_dom

Domain

13,536

false

X-linked lissencephaly is a severe brain malformation affecting males. Recently it has been demonstrated that the doublecortin gene is implicated in this disorder [ ]. Doublecortin was found to bind to the microtubule cytoskeleton. In vivo and in vitro assays show that Doublecortin stabilises microtubules and causes bu...

[ "GO:0035556" ]

[ "intracellular signal transduction" ]

[ "biological_process" ]

1

[ "PFAM", "PROFILE", "SMART" ]

[ "PF03607", "PS50309", "SM00537" ]

[ "DCX", "DC", "DCX" ]

[ 12188, 13438, 12315 ]

3

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME" ]

[ "PDOC50309", "R-DME-111932", "R-DME-442729", "R-HSA-447043" ]

[ "PROSITEDOC:PDOC50309", "REACTOME:R-DME-111932", "REACTOME:R-DME-442729", "REACTOME:R-HSA-447043" ]

4

[ "1mfw", "1mg4", "1mjd", "1uf0", "2bqq", "2dnf", "2xrp", "4atu", "5ikc", "5in7", "5io9", "5ioi", "5ip4", "6b4a", "6fnz", "6rev", "6rf2", "6rf8", "6rfd" ]

19

[ "PUB00006617", "PUB00006669", "PUB00006680", "PUB00018253", "PUB00018254", "PUB00077395", "PUB00097381" ]

[ "10749977", "9489699", "10441322", "10533048", "10401003", "19657028", "16684769" ]

[ "Doublecortin mutations cluster in evolutionarily conserved functional domains.", "A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndrome.", "Doublecortin, a stabilizer of microtubules.", "KIAA0369, doublecortin-like kinase, is expr...

[ 2000, 1998, 1999, 1999, 1999, 2009, 2006 ]

7

[]

[ "IPR033036" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Pithovirus LCPAC104", "marine sediment metagenome" ]

[ 3, 85, 13446, 1, 1 ]

5

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 8, 49, 6, 34, 37, 32 ]

6

true

Domain

Doublecortin domain

Doublecortin_dom

5

IPR003535

3,535

Intimin/invasin bacterial adhesion mediator protein

Intimin/invasin_bac

Family

3,323

false

Secretion of virulence factors in Gram-negative bacteria involves transportation of the protein across two membranes to reach the cell exterior. There have been four secretion systems described in animal enteropathogens, such as Salmonella and Yersinia, with further sequence similarities in plant pathogens like Ralston...

[ "GO:0007155" ]

[ "cell adhesion" ]

[ "biological_process" ]

1

[ "PRINTS" ]

[ "PR01369" ]

[ "INTIMIN" ]

[ 3323 ]

1

[]

0

[ "4e1s", "4e1t", "5g26" ]

3

[ "PUB00003585", "PUB00006621", "PUB00006623", "PUB00018560", "PUB00056156", "PUB00153750" ]

[ "9618447", "10835344", "10890451", "10514372", "3304658", "28900103" ]

[ "Type III protein secretion systems in bacterial pathogens of animals and plants.", "Structural basis for recognition of the translocated intimin receptor (Tir) by intimin from enteropathogenic Escherichia coli.", "Crystal structure of enteropathogenic Escherichia coli intimin-receptor complex.", "Crystal str...

[ 1998, 2000, 2000, 1999, 1987, 2017 ]

6

[]

0

null

[ "Callosobruchus maculatus", "Methanosarcina mazei", "Pseudomonadota" ]

[ 3, 1, 3319 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Intimin/invasin bacterial adhesion mediator protein

Intimin/invasin_bac

5

IPR003536

3,536

Translocated intimin receptor, central domain

Transloc_intimin_rcpt_cen_dom

Domain

134

false

Secretion of virulence factors in Gram-negative bacteria involves transportation of the protein across two membranes to reach the cell exterior. There have been four secretion systems described in animal enteropathogens, such as Salmonella and Yersinia, with further sequence similarities in plant pathogens like Ralston...

[ "GO:0005515" ]

[ "protein binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF03549" ]

[ "Tir_receptor_M" ]

[ 134 ]

1

[]

0

[ "1f02", "2zqk", "2zwk" ]

3

[ "PUB00003585", "PUB00006621", "PUB00014294" ]

[ "9618447", "10835344", "11207537" ]

[ "Type III protein secretion systems in bacterial pathogens of animals and plants.", "Structural basis for recognition of the translocated intimin receptor (Tir) by intimin from enteropathogenic Escherichia coli.", "Identification of the intimin-binding domain of Tir of enteropathogenic Escherichia coli." ]

[ 1998, 2000, 1999 ]

3

[]

0

null

[ "Enterobacterales" ]

[ 134 ]

1

[]

0

true

Domain

Translocated intimin receptor, central domain

Transloc_intimin_rcpt_cen_dom

6

IPR003537

3,537

Type III secretion system effector protein YopE-like

YopE-like

Family

147

false

Secretion of virulence factors in Gram-negative bacteria involves transportation of the protein across two membranes to reach the cell exterior. There have been four secretion systems described in animal enteropathogens, such as Salmonella and Yersinia, with further sequence similarities in plant pathogens like Ralston...

[ "GO:0005096" ]

[ "GTPase activator activity" ]

[ "molecular_function" ]

1

[ "PRINTS" ]

[ "PR01372" ]

[ "YERSINIAYOPE" ]

[ 147 ]

1

[]

0

[ "1he1", "1he9", "1hy5", "1l2w", "1r4t", "6jnp" ]

6

[ "PUB00003585", "PUB00006631", "PUB00006632", "PUB00006679", "PUB00069647", "PUB00095119" ]

[ "9618447", "2307658", "2191183", "10419539", "14594831", "26451042" ]

[ "Type III protein secretion systems in bacterial pathogens of animals and plants.", "Genetic analysis of the yopE region of Yersinia spp.: identification of a novel conserved locus, yerA, regulating yopE expression.", "The cytotoxic protein YopE of Yersinia obstructs the primary host defence.", "Yersinia ente...

[ 1998, 1990, 1990, 1999, 2003, 2015 ]

6

[]

0

null

[ "Bacteria" ]

[ 147 ]

1

[]

0

true

Family

Type III secretion system effector protein YopE-like

YopE-like

3