interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR003538 | 3,538 | Gram-negative bacterial TonB protein | TonB | Family | 13,242 | false | false | TonB-dependent transporters (TBDT) are bacterial outer membrane (OM) proteins that bind and transport ferric chelates called siderophores. While iron complexes constitute the majority of substrates for TBDTs, others, like vitamin B12, are also transported by this mechanism [ ]. These transporters show high affinity and... | [
"GO:0031992",
"GO:0015891",
"GO:0030288"
] | [
"energy transducer activity",
"siderophore transport",
"outer membrane-bounded periplasmic space"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01374"
] | [
"TONBPROTEIN"
] | [
13242
] | 1 | [
"GP",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"GenProp1157",
"R-HSA-9638334",
"R-HSA-9638482",
"R-HSA-9927020"
] | [
"GP:GenProp1157",
"REACTOME:R-HSA-9638334",
"REACTOME:R-HSA-9638482",
"REACTOME:R-HSA-9927020"
] | 4 | [
"1ihr",
"1qxx",
"1u07",
"2grx",
"2gsk",
"2k9k",
"5lw8",
"6fip",
"6i97",
"6sly",
"7zc8",
"8rd6",
"9ddo",
"9ddp",
"9ddq",
"9hi3"
] | 16 | [
"PUB00066236",
"PUB00066237",
"PUB00066240",
"PUB00066241",
"PUB00066246"
] | [
"20420522",
"18539464",
"23527057",
"17225063",
"17225934"
] | [
"TonB-dependent transporters: regulation, structure, and function.",
"New substrates for TonB-dependent transport: do we only see the 'tip of the iceberg'?",
"The Structure of HasB Reveals a New Class of TonB Protein Fold.",
"Bioinformatic analysis of the TonB protein family.",
"TonB-dependent energy transd... | [
2010,
2008,
2013,
2007,
2007
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"candidate division MSBL1 archaeon SCGC-AAA382M17",
"unclassified sequences"
] | [
13034,
3,
21,
2,
182
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Gram-negative bacterial TonB protein | Gram-negative bacterial TonB protein | TonB | 5 |
IPR003539 | 3,539 | Cytolethal distending toxin B | CD_toxinB | Family | 789 | false | false | Cytolethal distending toxin (CDT) is a secreted protein toxin produced by a number of Gram-negative disease-causing bacteria. CDT causes cell cycle arrest and eventual cell death in eukaryotic cells, as a result of chromosomal DNA damage caused by the catalytic, DNase I-like, CdtB subunit. Bacterial CDTs are generally ... | [] | [] | [] | 0 | [
"NCBIFAM",
"PIRSF",
"PRINTS",
"CDD"
] | [
"NF011787",
"PIRSF018539",
"PR01388",
"cd09081"
] | [
"PRK15251.1",
"CDT_B",
"CDTOXINB",
"CdtB"
] | [
644,
435,
775,
541
] | 4 | [] | [] | [] | 0 | [
"1sr4",
"2f1n",
"2f2f",
"4k6l",
"6vx4",
"7ee6",
"9kyc"
] | 7 | [
"PUB00037634",
"PUB00080560",
"PUB00080561",
"PUB00080562",
"PUB00104977"
] | [
"15164065",
"11583839",
"12947116",
"15713603",
"15070766"
] | [
"Assembly and function of a bacterial genotoxin.",
"Cytolethal distending toxin (CDT): a bacterial weapon to control host cell proliferation?",
"An N-terminal segment of the active component of the bacterial genotoxin cytolethal distending toxin B (CDTB) directs CDTB into the nucleus.",
"Cytolethal distending... | [
2004,
2001,
2003,
2005,
2004
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Endopterygota",
"Methanococcus maripaludis",
"Viruses"
] | [
771,
7,
5,
6
] | 4 | [] | [] | 0 | true | Family | Cytolethal distending toxin B | Cytolethal distending toxin B | CD_toxinB | 5 |
IPR003540 | 3,540 | ADP ribosyltransferase | ADP-ribosyltransferase | Domain | 6,156 | false | false | ADP-ribosylation is a posttranslational modification of proteins involving the addition of one or more ADP-ribose moieties [ , ]. These reactions are involved in cell signalling and the control of many cell processes, including DNA repair and apoptosis [ , ]. This entry represents an ADP-ribosyltransferase domain found... | [
"GO:0005576"
] | [
"extracellular region"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF03496"
] | [
"ADPrib_exo_Tox"
] | [
6156
] | 1 | [
"EC"
] | [
"2.4.2.31"
] | [
"EC:2.4.2.31"
] | 1 | [
"1g24",
"1giq",
"1gir",
"1gze",
"1gzf",
"1ojq",
"1ojz",
"1qs1",
"1qs2",
"1r45",
"1r4b",
"1uzi",
"2a78",
"2a9k",
"2bov",
"2c89",
"2c8a",
"2c8b",
"2c8c",
"2c8d",
"2c8e",
"2c8f",
"2c8g",
"2c8h",
"2gwl",
"2gwm",
"2j3v",
"2j3x",
"2j3z",
"2wn4",
"2wn5",
"2wn6"... | 84 | [
"PUB00053863",
"PUB00053864",
"PUB00053865",
"PUB00053866",
"PUB00095170"
] | [
"17161604",
"10712584",
"15003268",
"12727863",
"30232373"
] | [
"NAD+ metabolism in health and disease.",
"New functions of a long-known molecule. Emerging roles of NAD in cellular signaling.",
"The new life of a centenarian: signalling functions of NAD(P).",
"Functional aspects of protein mono-ADP-ribosylation.",
"Pseudomonas aeruginosa ExoS Induces Intrinsic Apoptosis... | [
2007,
2000,
2004,
2003,
2018
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"Viruses",
"metagenomes"
] | [
1879,
3608,
39,
597,
33
] | 5 | [] | [] | 0 | true | Domain | ADP ribosyltransferase | ADP ribosyltransferase | ADP-ribosyltransferase | 9 |
IPR003541 | 3,541 | Anthrax toxin, lethal/endema factor | Anthrax_toxin_lethal/edema | Family | 44 | false | false | Anthrax toxin is a plasmid-encoded toxin complex produced by the Gram-positive, spore-forming bacteria, Bacillus anthracis. The toxin consists of three non-toxic proteins: the protective antigen (PA), the lethal factor (LF) and the edema factor (EF) [ ]. These component proteins self-assemble at the surface of host cel... | [
"GO:0003824",
"GO:0046872",
"GO:0005576"
] | [
"catalytic activity",
"metal ion binding",
"extracellular region"
] | [
"molecular_function",
"molecular_function",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01392"
] | [
"ANTHRAXTOXNA"
] | [
44
] | 1 | [
"REACTOME"
] | [
"R-HSA-5210891"
] | [
"REACTOME:R-HSA-5210891"
] | 1 | [
"1j7n",
"1jky",
"1pwp",
"1pwq",
"1pwu",
"1pwv",
"1pww",
"1xfu",
"1xfv",
"1xfw",
"1xfx",
"1xfy",
"1xfz",
"1y0v",
"1zxv",
"3kwv",
"4fxq",
"4gf1",
"6psn",
"6uzb",
"6uzd",
"6uze",
"6vra",
"6wjj",
"6zxj",
"6zxk",
"6zxl",
"8fvu"
] | 28 | [
"PUB00026280",
"PUB00031089",
"PUB00035784",
"PUB00035785",
"PUB00035786",
"PUB00035787"
] | [
"11700563",
"15131111",
"14570563",
"17335404",
"17381430",
"14616089"
] | [
"Crystal structure of the anthrax lethal factor.",
"Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate.",
"Anthrax toxin.",
"Anthrax toxin: receptor binding, internalization, pore formation, and translocation.",
"Characterizatio... | [
2001,
2004,
2003,
2007,
2007,
2004
] | 6 | [] | [] | 0 | 0 | null | [
"Bacillales"
] | [
44
] | 1 | [] | [] | 0 | true | Family | Anthrax toxin, lethal/endema factor | Anthrax toxin, lethal/endema factor | Anthrax_toxin_lethal/edema | 8 |
IPR003542 | 3,542 | Enterobactin synthetase-like, component D | Enbac_synth_compD-like | Family | 7,519 | false | false | Iron is essential for growth in both bacteria and mammals. Controlling the amount of free iron in solution is often used as a tactic by hosts to limit invasion of pathogenic microbes; binding iron tightly within protein molecules can accomplish this. Such iron-protein complexes include haem in blood, lactoferrin in tea... | [
"GO:0016780",
"GO:0009239",
"GO:0009366"
] | [
"phosphotransferase activity, for other substituted phosphate groups",
"enterobactin biosynthetic process",
"enterobactin synthetase complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS",
"PANTHER"
] | [
"PR01399",
"PTHR38096"
] | [
"ENTSNTHTASED",
""
] | [
7099,
7492
] | 2 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.7.8.-",
"PWY-6350",
"PWY-6580",
"PWY-6804",
"PWY-7815",
"PWY-7816",
"PWY-7817",
"PWY-7818",
"PWY-7819",
"PWY-7820",
"PWY-7981",
"PWY-8248"
] | [
"EC:2.7.8.-",
"METACYC:PWY-6350",
"METACYC:PWY-6580",
"METACYC:PWY-6804",
"METACYC:PWY-7815",
"METACYC:PWY-7816",
"METACYC:PWY-7817",
"METACYC:PWY-7818",
"METACYC:PWY-7819",
"METACYC:PWY-7820",
"METACYC:PWY-7981",
"METACYC:PWY-8248"
] | 12 | [
"4qjk",
"4qjl",
"4u89",
"6ct5",
"6qwu",
"6qxq",
"6qxr",
"6qyf",
"6qyg",
"6rcx",
"7b4r",
"7b4s",
"7bcz",
"7bdw",
"7ed0",
"7ed1",
"7ed2",
"7n8e",
"7n8l",
"7n8m",
"8gkf",
"8qzh",
"8qzi",
"8qzj"
] | 24 | [
"PUB00006626",
"PUB00006627",
"PUB00006650",
"PUB00006668",
"PUB00091542"
] | [
"2521621",
"2521622",
"8057905",
"9371453",
"9214294"
] | [
"Nucleotide sequence and transcriptional organization of the Escherichia coli enterobactin biosynthesis cistrons entB and entA.",
"Nucleotide sequence of a cluster of Escherichia coli enterobactin biosynthesis genes: identification of entA and purification of its product 2,3-dihydro-2,3-dihydroxybenzoate dehydrog... | [
1989,
1989,
1994,
1997,
1997
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"environmental samples",
"metagenomes"
] | [
7460,
39,
3,
17
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Enterobactin synthetase-like, component D | Enterobactin synthetase-like, component D | Enbac_synth_compD-like | 8 |
IPR003543 | 3,543 | Macrophage scavenger receptor, Class A-I/II | SR-AI/II | Family | 521 | false | false | Scavenger receptors type I and II were the first scavenger receptors purified and are products of alternative splicing of a single gene. They are now named as class A, type I and type II (SR-AI/II) or collectively SR-A member 1. They can recognise a wide variety of ligands, from bacteria and yeast to self (native prote... | [
"GO:0005044",
"GO:0006898",
"GO:0016020"
] | [
"scavenger receptor activity",
"receptor-mediated endocytosis",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PRINTS"
] | [
"PF03523",
"PR01408"
] | [
"Macscav_rec",
"MACSCAVRCPTR"
] | [
408,
511
] | 2 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-3000480",
"R-MMU-3000480"
] | [
"REACTOME:R-HSA-3000480",
"REACTOME:R-MMU-3000480"
] | 2 | [] | 0 | [
"PUB00006630",
"PUB00006633",
"PUB00095351",
"PUB00095352"
] | [
"2300204",
"2251254",
"24563502",
"23782937"
] | [
"Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils.",
"Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions.",
"Standardizing scavenger receptor nomenclature.",
"Foam cells in atherosclerosis."
] | [
1990,
1990,
2014,
2013
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Vertebrata"
] | [
3,
518
] | 2 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
6,
4
] | 3 | true | Family | Macrophage scavenger receptor, Class A-I/II | Macrophage scavenger receptor, Class A-I/II | SR-AI/II | 1 |
IPR003544 | 3,544 | Cytochrome c-type biogenesis protein CcmB | Cyt_c_biogenesis_CcmB | Family | 12,219 | false | false | This entry represents cytochrome c-type biogenesis protein CcmB (HelB) from bacteria and plants. CcmB is the product of one of a cluster of ccm genes that are necessary for cytochrome c biosynthesis in bacteria and is required for the export of haem to the periplasm [ ]. Plant mitochondria have kept a cytochrome c biog... | [
"GO:0015232",
"GO:0015886",
"GO:0017004",
"GO:0016020"
] | [
"heme transmembrane transporter activity",
"heme transport",
"cytochrome complex assembly",
"membrane"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PFAM",
"PANTHER"
] | [
"PF03379",
"PTHR30070"
] | [
"CcmB",
""
] | [
11070,
10831
] | 2 | [] | [] | [] | 0 | [
"7f02",
"7f03",
"7f04",
"7vfj",
"7vfp",
"8ce1",
"8ce5",
"8ce8",
"8cea"
] | 9 | [
"PUB00002274",
"PUB00059293",
"PUB00059294"
] | [
"7635817",
"18033741",
"11418186"
] | [
"Escherichia coli genes required for cytochrome c maturation.",
"Cytochrome c biogenesis in mitochondria.",
"Wheat mitochondria ccmB encodes the membrane domain of a putative ABC transporter involved in cytochrome c biogenesis."
] | [
1995,
2008,
2001
] | 3 | [] | [
"IPR026031"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
143,
10319,
1473,
284
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
2,
1,
2,
1
] | 4 | true | Family | Cytochrome c-type biogenesis protein CcmB | Cytochrome c-type biogenesis protein CcmB | Cyt_c_biogenesis_CcmB | 3 |
IPR003545 | 3,545 | Telomerase reverse transcriptase | Telomerase_RT | Family | 5,262 | false | false | null | [
"GO:0003677",
"GO:0003720",
"GO:0000723"
] | [
"DNA binding",
"telomerase activity",
"telomere maintenance"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PRINTS",
"PANTHER"
] | [
"PR01365",
"PTHR12066"
] | [
"TELOMERASERT",
""
] | [
3417,
5200
] | 2 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.7.49",
"R-HSA-171319",
"R-HSA-201722",
"R-HSA-9825895",
"R-MMU-171319",
"R-MMU-201722",
"R-RNO-171319",
"R-RNO-201722"
] | [
"EC:2.7.7.49",
"REACTOME:R-HSA-171319",
"REACTOME:R-HSA-201722",
"REACTOME:R-HSA-9825895",
"REACTOME:R-MMU-171319",
"REACTOME:R-MMU-201722",
"REACTOME:R-RNO-171319",
"REACTOME:R-RNO-201722"
] | 8 | [
"2r4g",
"3du5",
"3du6",
"3kyl",
"4lmo",
"4o26",
"5c9h",
"5cqg",
"5ugw",
"6d6v",
"6e53",
"6uso",
"6usp",
"6usq",
"6usr",
"6zd1",
"6zd2",
"6zd6",
"6zdp",
"6zdq",
"6zdu",
"7bg9",
"7kqm",
"7kqn",
"7lma",
"7lmb",
"7qxa",
"7qxb",
"7qxs",
"7sbe",
"7trd",
"7tre"... | 40 | [
"PUB00006622",
"PUB00006624",
"PUB00006666"
] | [
"10866187",
"10860859",
"9110970"
] | [
"Risky immortalization by telomerase.",
"Telomerase: not just black and white, but shades of gray.",
"Reverse transcriptase motifs in the catalytic subunit of telomerase."
] | [
2000,
2000,
1997
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"mine drainage metagenome"
] | [
44,
5217,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"S... | [
6,
2,
1,
8,
8,
1,
3,
3,
1,
1,
15
] | 11 | true | Family | Telomerase reverse transcriptase | Telomerase reverse transcriptase | Telomerase_RT | 4 |
IPR003546 | 3,546 | Type III secreted modular tyrosine phosphatase, SptP/YopH | Tyr_Pase_SptP/YopH | Family | 744 | false | false | Secretion of virulence factors in Gram-negative bacteria involves transportation of the protein across two membranes to reach the cell exterior [ ]. There have been four secretion systems described in animal enteropathogens, such as Salmonella and Yersinia, with further sequence similarities in plant pathogens like Ral... | [
"GO:0004725",
"GO:0006470"
] | [
"protein tyrosine phosphatase activity",
"protein dephosphorylation"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PRINTS"
] | [
"PR01371"
] | [
"BACYPHPHTASE"
] | [
744
] | 1 | [
"EC"
] | [
"3.1.3.48"
] | [
"EC:3.1.3.48"
] | 1 | [
"1g4u",
"1g4w",
"1lyv",
"1pa9",
"1qz0",
"1xxp",
"1xxv",
"1ypt",
"1ytn",
"1yts",
"1ytw",
"2i42",
"2y2f",
"2ydu",
"3blt",
"3blu",
"3bm8",
"3f99",
"3f9a",
"3f9b",
"3u96",
"4yaa",
"4z6b",
"4zi4",
"4zn5",
"6dr1",
"6dr7",
"6dr9",
"6drb",
"6dt6",
"6xft",
"7l0i"... | 33 | [
"PUB00003585",
"PUB00006645",
"PUB00006659",
"PUB00006663",
"PUB00006683"
] | [
"9618447",
"8305677",
"8702535",
"8866485",
"10499590"
] | [
"Type III protein secretion systems in bacterial pathogens of animals and plants.",
"Bacterial and viral protein tyrosine phosphatases.",
"The X-ray crystal structures of Yersinia tyrosine phosphatase with bound tungstate and nitrate. Mechanistic implications.",
"A secreted protein tyrosine phosphatase with m... | [
1998,
1993,
1996,
1996,
1999
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadota"
] | [
13,
731
] | 2 | [] | [] | 0 | true | Family | Type III secreted modular tyrosine phosphatase, SptP/YopH | Type III secreted modular tyrosine phosphatase, SptP/YopH | Tyr_Pase_SptP/YopH | 2 |
IPR003547 | 3,547 | Serine/threonine protein kinase, yersinia-type | Ser/thr_kinase_yersinia-type | Family | 20 | false | false | null | [
"GO:0004674",
"GO:0006468"
] | [
"protein serine/threonine kinase activity",
"protein phosphorylation"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PRINTS"
] | [
"PR01373"
] | [
"YERSSTKINASE"
] | [
20
] | 1 | [] | [] | [] | 0 | [
"2h7o",
"2h7v",
"4ci6",
"5ce3"
] | 4 | [
"PUB00003585",
"PUB00006641",
"PUB00006648",
"PUB00006660"
] | [
"9618447",
"8441468",
"8045884",
"8736538"
] | [
"Type III protein secretion systems in bacterial pathogens of animals and plants.",
"A secreted protein kinase of Yersinia pseudotuberculosis is an indispensable virulence determinant.",
"Characterization of the operon encoding the YpkA Ser/Thr protein kinase and the YopJ protein of Yersinia pseudotuberculosis.... | [
1998,
1993,
1994,
1996
] | 4 | [] | [] | 0 | 0 | null | [
"Pseudomonadota"
] | [
20
] | 1 | [] | [] | 0 | true | Family | Serine/threonine protein kinase, yersinia-type | Serine/threonine protein kinase, yersinia-type | Ser/thr_kinase_yersinia-type | 5 |
IPR003548 | 3,548 | Claudin-1 | Claudin1 | Family | 595 | false | false | Claudins form the paracellular tight junction seal in epithelial tissues. In humans, 24 claudins (claudin 1-24) have been identified. Their ability to polymerise and form strands is affected by the cell types [ , , ]. They can also form heteropolymers with each other within and between tight junction strands [ ]. Most ... | [
"GO:0005198",
"GO:0005923"
] | [
"structural molecule activity",
"bicellular tight junction"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01377"
] | [
"CLAUDIN1"
] | [
595
] | 1 | [
"REACTOME"
] | [
"R-HSA-420029"
] | [
"REACTOME:R-HSA-420029"
] | 1 | [] | 0 | [
"PUB00003085",
"PUB00006674",
"PUB00070979",
"PUB00070980",
"PUB00070981",
"PUB00070982"
] | [
"9647647",
"9931503",
"24665401",
"20188437",
"21372174",
"10562289"
] | [
"Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin.",
"SEMP1, a senescence-associated cDNA isolated from human mammary epithelial cells, is a member of an epithelial membrane protein superfamily.",
"Claudin interactions in and out of the tig... | [
1998,
1999,
2013,
2010,
2011,
1999
] | 6 | [
"IPR006187"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
595
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
3,
2
] | 3 | true | Family | Claudin-1 | Claudin-1 | Claudin1 | 9 |
IPR003550 | 3,550 | Claudin-4 | Claudin4 | Family | 223 | false | false | Claudins form the paracellular tight junction seal in epithelial tissues. In humans, 24 claudins (claudin 1-24) have been identified. Their ability to polymerise and form strands is affected by the cell types [ , , ]. They can also form heteropolymers with each other within and between tight junction strands [ ]. Most ... | [
"GO:0005198",
"GO:0005923"
] | [
"structural molecule activity",
"bicellular tight junction"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01379"
] | [
"CLAUDIN4"
] | [
223
] | 1 | [
"REACTOME"
] | [
"R-HSA-420029"
] | [
"REACTOME:R-HSA-420029"
] | 1 | [
"7kp4",
"7tdm",
"7tdn",
"8u4v",
"8u5b",
"9cmh",
"9cmi"
] | 7 | [
"PUB00004927",
"PUB00070979",
"PUB00070980",
"PUB00070981",
"PUB00070982"
] | [
"9892664",
"24665401",
"20188437",
"21372174",
"10562289"
] | [
"Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands.",
"Claudin interactions in and out of the tight junction.",
"The protoplasmic or exoplasmic face association of tight junction particles cannot predict paracellular permeability or heterotypic claudin comp... | [
1999,
2013,
2010,
2011,
1999
] | 5 | [
"IPR006187"
] | [] | 1 | 0 | 1 | [
"Tetrapoda"
] | [
223
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
2,
2
] | 3 | true | Family | Claudin-4 | Claudin-4 | Claudin4 | 3 |
IPR003551 | 3,551 | Claudin-5 | Claudin5 | Family | 497 | false | false | Claudins form the paracellular tight junction seal in epithelial tissues. In humans, 24 claudins (claudin 1-24) have been identified. Their ability to polymerise and form strands is affected by the cell types [ , , ]. They can also form heteropolymers with each other within and between tight junction strands [ ]. Most ... | [
"GO:0005198",
"GO:0005923"
] | [
"structural molecule activity",
"bicellular tight junction"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01380"
] | [
"CLAUDIN5"
] | [
497
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-420029",
"R-HSA-8935964"
] | [
"REACTOME:R-HSA-420029",
"REACTOME:R-HSA-8935964"
] | 2 | [] | 0 | [
"PUB00004927",
"PUB00006667",
"PUB00070979",
"PUB00070980",
"PUB00070981",
"PUB00070982"
] | [
"9892664",
"9192844",
"24665401",
"20188437",
"21372174",
"10562289"
] | [
"Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands.",
"Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome.",
"Claudin interactions in ... | [
1999,
1997,
2013,
2010,
2011,
1999
] | 6 | [
"IPR006187"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
497
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
1,
2
] | 3 | true | Family | Claudin-5 | Claudin-5 | Claudin5 | 5 |
IPR003552 | 3,552 | Claudin-7 | Claudin7 | Family | 196 | false | false | Claudins form the paracellular tight junction seal in epithelial tissues. In humans, 24 claudins (claudin 1-24) have been identified. Their ability to polymerise and form strands is affected by the cell types [ , , ]. They can also form heteropolymers with each other within and between tight junction strands [ ]. Most ... | [
"GO:0005198",
"GO:0005923"
] | [
"structural molecule activity",
"bicellular tight junction"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01381"
] | [
"CLAUDIN7"
] | [
196
] | 1 | [
"REACTOME"
] | [
"R-HSA-420029"
] | [
"REACTOME:R-HSA-420029"
] | 1 | [] | 0 | [
"PUB00004927",
"PUB00070979",
"PUB00070980",
"PUB00070981",
"PUB00070982"
] | [
"9892664",
"24665401",
"20188437",
"21372174",
"10562289"
] | [
"Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands.",
"Claudin interactions in and out of the tight junction.",
"The protoplasmic or exoplasmic face association of tight junction particles cannot predict paracellular permeability or heterotypic claudin comp... | [
1999,
2013,
2010,
2011,
1999
] | 5 | [
"IPR006187"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
196
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
2,
4
] | 3 | true | Family | Claudin-7 | Claudin-7 | Claudin7 | 8 |
IPR003553 | 3,553 | Claudin-9 | Claudin9 | Family | 196 | false | false | Claudins form the paracellular tight junction seal in epithelial tissues. In humans, 24 claudins (claudin 1-24) have been identified. Their ability to polymerise and form strands is affected by the cell types [ , , ]. They can also form heteropolymers with each other within and between tight junction strands [ ]. Most ... | [
"GO:0005198",
"GO:0005923"
] | [
"structural molecule activity",
"bicellular tight junction"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01382"
] | [
"CLAUDIN9"
] | [
196
] | 1 | [
"REACTOME"
] | [
"R-HSA-420029"
] | [
"REACTOME:R-HSA-420029"
] | 1 | [
"6ov2",
"6ov3"
] | 2 | [
"PUB00005988",
"PUB00070979",
"PUB00070980",
"PUB00070981",
"PUB00070982"
] | [
"10370242",
"24665401",
"20188437",
"21372174",
"10562289"
] | [
"Occludin and claudins in tight-junction strands: leading or supporting players?",
"Claudin interactions in and out of the tight junction.",
"The protoplasmic or exoplasmic face association of tight junction particles cannot predict paracellular permeability or heterotypic claudin compatibility.",
"Role of cl... | [
1999,
2013,
2010,
2011,
1999
] | 5 | [
"IPR006187"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
196
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
2
] | 3 | true | Family | Claudin-9 | Claudin-9 | Claudin9 | 9 |
IPR003554 | 3,554 | Claudin-10 | Claudin10 | Family | 1,039 | false | false | Claudins form the paracellular tight junction seal in epithelial tissues. In humans, 24 claudins (claudin 1-24) have been identified. Their ability to polymerise and form strands is affected by the cell types [ , , ]. They can also form heteropolymers with each other within and between tight junction strands [ ]. Most ... | [
"GO:0005198",
"GO:0005923"
] | [
"structural molecule activity",
"bicellular tight junction"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01383"
] | [
"CLAUDIN10"
] | [
1039
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-420029",
"R-HSA-9925563"
] | [
"REACTOME:R-HSA-420029",
"REACTOME:R-HSA-9925563"
] | 2 | [] | 0 | [
"PUB00005988",
"PUB00070979",
"PUB00070980",
"PUB00070981",
"PUB00070982"
] | [
"10370242",
"24665401",
"20188437",
"21372174",
"10562289"
] | [
"Occludin and claudins in tight-junction strands: leading or supporting players?",
"Claudin interactions in and out of the tight junction.",
"The protoplasmic or exoplasmic face association of tight junction particles cannot predict paracellular permeability or heterotypic claudin compatibility.",
"Role of cl... | [
1999,
2013,
2010,
2011,
1999
] | 5 | [
"IPR006187"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
1039
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
1,
2,
6
] | 4 | true | Family | Claudin-10 | Claudin-10 | Claudin10 | 4 |
IPR003555 | 3,555 | Claudin-11 | Claudin11 | Family | 957 | false | false | Claudins form the paracellular tight junction seal in epithelial tissues. In humans, 24 claudins (claudin 1-24) have been identified. Their ability to polymerise and form strands is affected by the cell types [ , , ]. They can also form heteropolymers with each other within and between tight junction strands [ ]. Most ... | [
"GO:0005198",
"GO:0005923"
] | [
"structural molecule activity",
"bicellular tight junction"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01384"
] | [
"CLAUDIN11"
] | [
957
] | 1 | [
"REACTOME"
] | [
"R-HSA-420029"
] | [
"REACTOME:R-HSA-420029"
] | 1 | [] | 0 | [
"PUB00009541",
"PUB00070979",
"PUB00070980",
"PUB00070981",
"PUB00070982"
] | [
"11309411",
"24665401",
"20188437",
"21372174",
"10562289"
] | [
"OSP/claudin-11 forms a complex with a novel member of the tetraspanin super family and beta1 integrin and regulates proliferation and migration of oligodendrocytes.",
"Claudin interactions in and out of the tight junction.",
"The protoplasmic or exoplasmic face association of tight junction particles cannot pr... | [
2001,
2013,
2010,
2011,
1999
] | 5 | [
"IPR006187"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
957
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
1,
4
] | 4 | true | Family | Claudin-11 | Claudin-11 | Claudin11 | 1 |
IPR003557 | 3,557 | Cytochrome c-type biogenesis protein CcmC | Cyt_c_biogenesis_CcmC | Family | 12,307 | false | false | Within mitochondria and bacteria, a family of related proteins is involved in the assembly of periplasmic c-type cytochromes: these include CycK [ ], CcmF [ , ], NrfE [ ] and CcbS [ ]. These proteins may play a role in guidance of apocytochromes and haem groups for their covalent linkage by the cytochrome-c-haem lyase.... | [
"GO:0015232",
"GO:0015886",
"GO:0017004",
"GO:0016020"
] | [
"heme transmembrane transporter activity",
"heme transport",
"cytochrome complex assembly",
"membrane"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PRINTS",
"NCBIFAM"
] | [
"PR01386",
"TIGR01191"
] | [
"CCMCBIOGNSIS",
"ccmC"
] | [
12242,
9361
] | 2 | [
"GP"
] | [
"GenProp0678"
] | [
"GP:GenProp0678"
] | 1 | [
"7f02",
"7f03",
"7f04",
"7vfj",
"7vfp",
"8ce1",
"8ce5",
"8ce8",
"8cea"
] | 9 | [
"PUB00002274",
"PUB00002276",
"PUB00003599",
"PUB00006638",
"PUB00006642",
"PUB00006649"
] | [
"7635817",
"7665469",
"9043133",
"1310666",
"8389979",
"8057835"
] | [
"Escherichia coli genes required for cytochrome c maturation.",
"Characterization of the cycHJKL genes involved in cytochrome c biogenesis and symbiotic nitrogen fixation in Rhizobium leguminosarum.",
"The Paracoccus denitrificans ccmA, B and C genes: cloning and sequencing, and analysis of the potential of the... | [
1995,
1995,
1997,
1992,
1993,
1994
] | 6 | [
"IPR045062"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
150,
10355,
1528,
274
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
10,
1,
3,
1
] | 4 | true | Family | Cytochrome c-type biogenesis protein CcmC | Cytochrome c-type biogenesis protein CcmC | Cyt_c_biogenesis_CcmC | 3 |
IPR003559 | 3,559 | Cytolethal distending toxin C | CDtoxinC | Family | 85 | false | false | null | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR01389"
] | [
"CDTOXINC"
] | [
85
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00006618",
"PUB00006646",
"PUB00006675"
] | [
"10777111",
"8112838",
"10203548"
] | [
"Sequence of lethal events in HeLa cells exposed to the G2 blocking cytolethal distending toxin.",
"Cloning, sequencing, and expression of the Escherichia coli cytolethal distending toxin genes.",
"Cytolethal distending toxin genes in Campylobacter jejuni and Campylobacter coli isolates: detection and analysis ... | [
2000,
1994,
1999
] | 3 | [
"IPR003558"
] | [] | 1 | 0 | 1 | [
"Pseudomonadota",
"Viruses"
] | [
82,
3
] | 2 | [] | [] | 0 | true | Family | Cytolethal distending toxin C | Cytolethal distending toxin C | CDtoxinC | 9 |
IPR003560 | 3,560 | 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase | DHB_DH | Family | 5,650 | false | false | The absence of free iron molecules in the surrounding environment triggers transcription of gene clusters that encode both siderophore-synthesis enzymes, and receptors that recognise iron-bound siderophores [ ]. Classic examples are the enterobactin/enterochelin clusters found in Escherichia coli and Salmonella, althou... | [
"GO:0008667",
"GO:0019290"
] | [
"2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity",
"siderophore biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PRINTS",
"NCBIFAM",
"CDD"
] | [
"PR01397",
"TIGR04316",
"cd05331"
] | [
"DHBDHDRGNASE",
"dhbA_paeA",
"DH-DHB-DH_SDR_c"
] | [
5511,
3268,
1005
] | 3 | [
"EC",
"GP",
"GP",
"METACYC"
] | [
"1.3.1.28",
"GenProp1058",
"GenProp1336",
"PWY-5901"
] | [
"EC:1.3.1.28",
"GP:GenProp1058",
"GP:GenProp1336",
"METACYC:PWY-5901"
] | 4 | [
"2fwm",
"8sbv",
"8sbw",
"8sbx",
"8sby",
"8sbz",
"8sc0",
"8u9a"
] | 8 | [
"PUB00006626",
"PUB00006627",
"PUB00006668",
"PUB00064927"
] | [
"2521621",
"2521622",
"9371453",
"8921902"
] | [
"Nucleotide sequence and transcriptional organization of the Escherichia coli enterobactin biosynthesis cistrons entB and entA.",
"Nucleotide sequence of a cluster of Escherichia coli enterobactin biosynthesis genes: identification of entA and purification of its product 2,3-dihydro-2,3-dihydroxybenzoate dehydrog... | [
1989,
1989,
1997,
1996
] | 4 | [
"IPR002347"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
18,
5045,
521,
66
] | 4 | [
"Escherichia coli (strain K12)",
"Homo sapiens",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
1,
1,
3,
2
] | 4 | true | Family | 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase | 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase | DHB_DH | 4 |
IPR003561 | 3,561 | Mutator MutT | Mutator_MutT | Family | 6,526 | false | false | MutT is a small bacterial protein (~12-15kDa) involved in the GO system [ ]. MutT is known as a mutator gene because mutations in the gene specifically increase the rate of AT:GC tranversions. MutT is a 7,8-dihydro-8-oxoguanine triphosphatase converting 8-oxoguanine triphosphatase to the monophosphate with high efficie... | [
"GO:0008413",
"GO:0006281"
] | [
"8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity",
"DNA repair"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PRINTS",
"NCBIFAM"
] | [
"PR01401",
"TIGR00586"
] | [
"MUTATORMUTT",
"mutt"
] | [
1694,
6514
] | 2 | [
"EC",
"METACYC"
] | [
"3.6.1.55",
"PWY-6502"
] | [
"EC:3.6.1.55",
"METACYC:PWY-6502"
] | 2 | [
"1mut",
"1ppx",
"1pun",
"1puq",
"1pus",
"1tum",
"3a6s",
"3a6t",
"3a6u",
"3a6v",
"3ees",
"3eeu",
"3ef5",
"3ffu",
"3hhj",
"4v14",
"7syc",
"7ww5",
"7ww6",
"7ww7",
"7ww8",
"7ww9",
"7wwa",
"7x9h",
"7x9i",
"7x9j",
"7x9k",
"7x9l",
"7x9n",
"7x9o"
] | 30 | [
"PUB00002202",
"PUB00002808",
"PUB00003856",
"PUB00004433",
"PUB00006656",
"PUB00006662",
"PUB00006677",
"PUB00053829",
"PUB00053830",
"PUB00101991"
] | [
"1328155",
"8226881",
"8170394",
"8233837",
"7578113",
"8810257",
"10373642",
"9311918",
"15850400",
"25294823"
] | [
"The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine).",
"Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis.",
"Characterization of the mutX gene of Streptococcus pneum... | [
1992,
1993,
1994,
1993,
1995,
1996,
1999,
1997,
2005,
2014
] | 10 | [
"IPR047127"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
6458,
9,
59
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Mutator MutT | Mutator MutT | Mutator_MutT | 9 |
IPR003562 | 3,562 | Mutator MutX protein | Mutator_MutX_prot | Family | 1,803 | false | false | Like MutT ( ), MutX protein hydrolyses all canonical nucleoside triphosphates at different rates, with a preference for dGTP, yielding nucleoside monophosphates and inorganic pyrophosphate [ ]. Despite the similarity in enzymatic activity, the two proteins have distinct primary and quaternary structures. Their sequence... | [
"GO:0008413",
"GO:0006281"
] | [
"8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity",
"DNA repair"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PRINTS"
] | [
"PR01402"
] | [
"MUTATORMUTX"
] | [
1803
] | 1 | [
"EC",
"METACYC"
] | [
"3.6.1.55",
"PWY-6502"
] | [
"EC:3.6.1.55",
"METACYC:PWY-6502"
] | 2 | [] | 0 | [
"PUB00006647"
] | [
"8163538"
] | [
"Purification of the MutX protein of Streptococcus pneumoniae, a homologue of Escherichia coli MutT. Identification of a novel catalytic domain for nucleoside triphosphate pyrophosphohydrolase activity."
] | [
1994
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"metagenomes"
] | [
1786,
2,
15
] | 3 | [] | [] | 0 | true | Family | Mutator MutX protein | Mutator MutX protein | Mutator_MutX_prot | 7 |
IPR003564 | 3,564 | Dihydroneopterin triphosphate diphosphatase | DHNTPase | Family | 2,876 | false | false | Dihydroneopterin triphosphate diphosphatase is a Nudix domain containing enzyme involved in folate biosynthesis. It catalyses the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. It can also hydrolyse nucleoside triphosphates with a preference for dATP [ , ]. | [
"GO:0008828",
"GO:0019177",
"GO:0046656"
] | [
"dATP diphosphatase activity",
"dihydroneopterin triphosphate pyrophosphohydrolase activity",
"folic acid biosynthetic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PRINTS"
] | [
"PR01404"
] | [
"NPPPHYDRLASE"
] | [
2876
] | 1 | [
"EC",
"METACYC"
] | [
"3.6.1.67",
"PWY-6147"
] | [
"EC:3.6.1.67",
"METACYC:PWY-6147"
] | 2 | [
"2o1c",
"2o5w",
"5u7e",
"5u7f",
"5u7h"
] | 5 | [
"PUB00048421",
"PUB00048422"
] | [
"17698004",
"8798731"
] | [
"Structure and function of the E. coli dihydroneopterin triphosphate pyrophosphatase: a Nudix enzyme involved in folate biosynthesis.",
"Escherichia coli orf17 codes for a nucleoside triphosphate pyrophosphohydrolase member of the MutT family of proteins. Cloning, purification, and characterization of the enzyme.... | [
2007,
1996
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Beauveria bassiana D1-5",
"metagenomes"
] | [
2860,
1,
15
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Dihydroneopterin triphosphate diphosphatase | Dihydroneopterin triphosphate diphosphatase | DHNTPase | 4 |
IPR003565 | 3,565 | Bis(5'-nucleosyl)-tetraphosphatase | Tetra_PHTase | Family | 3,045 | false | false | Bis(5'-nucleosyl)-tetraphosphatase, also known as diadenosine tetraphosphate (Ap4A) hydrolase, is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms [ ]. Phylogenetic analysis reveals two distinct subgroups where plant enzymes fall into... | [
"GO:0008796"
] | [
"bis(5'-nucleosyl)-tetraphosphatase activity"
] | [
"molecular_function"
] | 1 | [
"PRINTS",
"CDD"
] | [
"PR01405",
"cd03428"
] | [
"TETRPHPHTASE",
"NUDIX_Ap4A_Nudt2"
] | [
1424,
3014
] | 2 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.6.1.17",
"R-BTA-3299685",
"R-CEL-3299685",
"R-HSA-3299685",
"R-MMU-3299685",
"R-RNO-3299685",
"R-SSC-3299685"
] | [
"EC:3.6.1.17",
"REACTOME:R-BTA-3299685",
"REACTOME:R-CEL-3299685",
"REACTOME:R-HSA-3299685",
"REACTOME:R-MMU-3299685",
"REACTOME:R-RNO-3299685",
"REACTOME:R-SSC-3299685"
] | 7 | [
"1kt9",
"1ktg",
"1xsa",
"1xsb",
"1xsc",
"3u53",
"4ick",
"4ijx",
"4ilq",
"4mpo",
"5cfi",
"5cfj"
] | 12 | [
"PUB00006662",
"PUB00034750",
"PUB00079688",
"PUB00079689",
"PUB00085970",
"PUB00085971"
] | [
"8810257",
"16378245",
"15581572",
"16359314",
"14739989",
"11007995"
] | [
"The MutT proteins or \"Nudix\" hydrolases, a family of versatile, widely distributed, \"housecleaning\" enzymes.",
"The Nudix hydrolase superfamily.",
"Structures and mechanisms of Nudix hydrolases.",
"House cleaning, a part of good housekeeping.",
"Analogs of diadenosine tetraphosphate (Ap4A).",
"Specif... | [
1996,
2006,
2005,
2006,
2003,
2000
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
472,
1004,
1544,
25
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
3,
1,
2,
2
] | 6 | true | Family | Bis(5'-nucleosyl)-tetraphosphatase | Bis(5'-nucleosyl)-tetraphosphatase | Tetra_PHTase | 1 |
IPR003566 | 3,566 | T-cell surface glycoprotein CD5 | Tcell_CD5 | Family | 633 | false | false | null | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PRINTS",
"PANTHER"
] | [
"PR01409",
"PTHR47309"
] | [
"TCELLCD5",
""
] | [
548,
574
] | 2 | [] | [] | [] | 0 | [
"2ja4",
"2jop",
"2jp0",
"2ott"
] | 4 | [
"PUB00004674",
"PUB00004717",
"PUB00006625",
"PUB00006634"
] | [
"2538832",
"1978939",
"3093892",
"1711157"
] | [
"Cloning of the mRNA for the protein that crosslinks to the egg peptide speract.",
"An ancient, highly conserved family of cysteine-rich protein domains revealed by cloning type I and type II murine macrophage scavenger receptors.",
"Isolation of complementary DNA clones encoding the human lymphocyte glycoprote... | [
1989,
1990,
1986,
1991
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"viral metagenome"
] | [
18,
614,
1
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
12,
7,
9
] | 4 | true | Family | T-cell surface glycoprotein CD5 | T-cell surface glycoprotein CD5 | Tcell_CD5 | 3 |
IPR003567 | 3,567 | Cytochrome c-type biogenesis protein | Cyt_c_biogenesis | Family | 15,646 | false | false | Within mitochondria and bacteria, a family of related proteins is involved in the assembly of periplasmic c-type cytochromes: these include CycK [ ], CcmF [ , ], NrfE [ ] and CcbS [ ]. These proteins may play a role in guidance of apocytochromes and haem groups for their covalent linkage by the cytochrome-c-haem lyase.... | [
"GO:0015232",
"GO:0015886",
"GO:0017004",
"GO:0016020"
] | [
"heme transmembrane transporter activity",
"heme transport",
"cytochrome complex assembly",
"membrane"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PRINTS",
"PANTHER"
] | [
"PR01410",
"PTHR43653"
] | [
"CCBIOGENESIS",
""
] | [
15216,
15613
] | 2 | [] | [] | [] | 0 | [
"6zmq"
] | 1 | [
"PUB00002274",
"PUB00002276",
"PUB00003599",
"PUB00006642",
"PUB00006649"
] | [
"7635817",
"7665469",
"9043133",
"8389979",
"8057835"
] | [
"Escherichia coli genes required for cytochrome c maturation.",
"Characterization of the cycHJKL genes involved in cytochrome c biogenesis and symbiotic nitrogen fixation in Rhizobium leguminosarum.",
"The Paracoccus denitrificans ccmA, B and C genes: cloning and sequencing, and analysis of the potential of the... | [
1995,
1995,
1997,
1993,
1994
] | 5 | [] | [
"IPR003568",
"IPR003569"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
180,
13539,
1614,
313
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
9,
2,
6,
2
] | 4 | true | Family | Cytochrome c-type biogenesis protein | Cytochrome c-type biogenesis protein | Cyt_c_biogenesis | 9 |
IPR003568 | 3,568 | Cytochrome c-type biogenesis protein CcmF | Cyt_c_biogenesis_CcmF | Family | 11,394 | false | false | Within mitochondria and bacteria, a family of related proteins is involved in the assembly of periplasmic c-type cytochromes: these include CycK [ ], CcmF [ , ], NrfE [ ] and CcbS [ ]. These proteins may play a role in guidance of apocytochromes and haem groups for their covalent linkage by the cytochrome-c-haem lyase.... | [
"GO:0015232",
"GO:0015886",
"GO:0017004",
"GO:0016020"
] | [
"heme transmembrane transporter activity",
"heme transport",
"cytochrome complex assembly",
"membrane"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PRINTS",
"NCBIFAM"
] | [
"PR01411",
"TIGR00353"
] | [
"CCMFBIOGNSIS",
"nrfE"
] | [
10901,
9392
] | 2 | [
"GP"
] | [
"GenProp0678"
] | [
"GP:GenProp0678"
] | 1 | [] | 0 | [
"PUB00002274",
"PUB00002276",
"PUB00003599",
"PUB00006638",
"PUB00006642",
"PUB00006649",
"PUB00006653"
] | [
"7635817",
"7665469",
"9043133",
"1310666",
"8389979",
"8057835",
"7715601"
] | [
"Escherichia coli genes required for cytochrome c maturation.",
"Characterization of the cycHJKL genes involved in cytochrome c biogenesis and symbiotic nitrogen fixation in Rhizobium leguminosarum.",
"The Paracoccus denitrificans ccmA, B and C genes: cloning and sequencing, and analysis of the potential of the... | [
1995,
1995,
1997,
1992,
1993,
1994,
1995
] | 7 | [
"IPR003567"
] | [
"IPR003570",
"IPR017563"
] | 1 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
10,
11124,
26,
234
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Cytochrome c-type biogenesis protein CcmF | Cytochrome c-type biogenesis protein CcmF | Cyt_c_biogenesis_CcmF | 3 |
IPR003569 | 3,569 | Probable cytochrome c biosynthesis protein, plants | Cyt_c_biogenesis_plant | Family | 1,423 | false | false | Analysis of a transcribed region in the mitochondrial genome from members of the genus Oenothera, revealed an open reading frame (ORF) that is also conserved in Daucus carota (Carrot) [ ]. Extensive RNA editing (46 C to U transitions) alters the Oenothera bertiana mRNA sequence, yielding a sequence with high similarity... | [
"GO:0015232",
"GO:0015886",
"GO:0017004",
"GO:0016020"
] | [
"heme transmembrane transporter activity",
"heme transport",
"cytochrome complex assembly",
"membrane"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PIRSF",
"PRINTS"
] | [
"PIRSF005240",
"PR01412"
] | [
"Cytc_biog_CcbS",
"CCBSBIOGNSIS"
] | [
854,
1405
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00006642"
] | [
"8389979"
] | [
"A plant mitochondrial gene encodes a protein involved in cytochrome c biogenesis."
] | [
1993
] | 1 | [
"IPR003567"
] | [] | 1 | 0 | 1 | [
"Streptophytina"
] | [
1423
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
7,
6,
2
] | 3 | true | Family | Probable cytochrome c biosynthesis protein, plants | Probable cytochrome c biosynthesis protein, plants | Cyt_c_biogenesis_plant | 5 |
IPR003570 | 3,570 | Cytochrome c-type biogenesis protein NrfE | Cyt_c_biogenesis_NrfE | Family | 1,305 | false | false | Within mitochondria and bacteria, a family of related proteins is involved in the assembly of periplasmic c-type cytochromes: these include CycK [ ], CcmF [ , ], NrfE [ ] and CcbS [ ]. These proteins may play a role in guidance of apocytochromes and haem groups for their covalent linkage by the cytochrome-c-haem lyase.... | [
"GO:0015232",
"GO:0015886",
"GO:0017004",
"GO:0016020"
] | [
"heme transmembrane transporter activity",
"heme transport",
"cytochrome complex assembly",
"membrane"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PRINTS"
] | [
"PR01413"
] | [
"NRFEBIOGNSIS"
] | [
1305
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00002274",
"PUB00002276",
"PUB00003599",
"PUB00006642",
"PUB00006649"
] | [
"7635817",
"7665469",
"9043133",
"8389979",
"8057835"
] | [
"Escherichia coli genes required for cytochrome c maturation.",
"Characterization of the cycHJKL genes involved in cytochrome c biogenesis and symbiotic nitrogen fixation in Rhizobium leguminosarum.",
"The Paracoccus denitrificans ccmA, B and C genes: cloning and sequencing, and analysis of the potential of the... | [
1995,
1995,
1997,
1993,
1994
] | 5 | [
"IPR003568"
] | [] | 1 | 0 | 1 | [
"Pseudomonadota",
"marine sediment metagenome"
] | [
1304,
1
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Cytochrome c-type biogenesis protein NrfE | Cytochrome c-type biogenesis protein NrfE | Cyt_c_biogenesis_NrfE | 7 |
IPR003571 | 3,571 | Snake three-finger toxin | Snake_3FTx | Family | 1,205 | false | false | Three finger toxins (3FTx) constitute an important superfamily of snake venom proteins. All have three β-stranded loops resembling three fingers, emerging from a globular core and stabilised by four conserved disulfide bridges. They are diverse in their biological functions, and include neurotoxins, cardiotoxins, cytot... | [
"GO:0090729",
"GO:0005576"
] | [
"toxin activity",
"extracellular region"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"CDD"
] | [
"cd00206"
] | [
"TFP_snake_toxin"
] | [
1205
] | 1 | [
"PROSITEDOC"
] | [
"PDOC00245"
] | [
"PROSITEDOC:PDOC00245"
] | 1 | [
"1abt",
"1b41",
"1bxp",
"1cb9",
"1ccq",
"1cdt",
"1chv",
"1cod",
"1coe",
"1cre",
"1crf",
"1ctx",
"1cvo",
"1cxn",
"1cxo",
"1drs",
"1era",
"1f8u",
"1fas",
"1ff4",
"1ffj",
"1fra",
"1fsc",
"1fss",
"1g6m",
"1h0j",
"1haa",
"1haj",
"1hc9",
"1hoy",
"1i02",
"1idg"... | 180 | [
"PUB00023016",
"PUB00037712",
"PUB00074532",
"PUB00074537",
"PUB00074538",
"PUB00097201",
"PUB00097874"
] | [
"1939183",
"7727450",
"24966535",
"3277206",
"2126462",
"14505938",
"33672715"
] | [
"The refined crystal structure of alpha-cobratoxin from Naja naja siamensis at 2.4-A resolution.",
"NMR and restrained molecular dynamics study of the three-dimensional solution structure of toxin FS2, a specific blocker of the L-type calcium channel, isolated from black mamba venom.",
"A comparative in silico ... | [
1991,
1995,
2014,
1988,
1990,
2003,
2021
] | 7 | [] | [
"IPR003572"
] | 0 | 1 | 0 | [
"Bacteria",
"Eumetazoa"
] | [
3,
1202
] | 2 | [] | [] | 0 | true | Family | Snake three-finger toxin | Snake three-finger toxin | Snake_3FTx | 4 |
IPR003572 | 3,572 | Snake cytotoxin, cobra-type | Cytotoxin_Cobra | Family | 151 | false | false | Snake toxins belong to a family of proteins [ ] which groups short and long neurotoxins, cytotoxins and short toxins, as well as a other miscellanous venom peptides. Cytotoxins (CTs) are small (~60 amino acids) proteins, which are abundant in the venom of the snakes of the Elapidae family [ ]. The cytotoxic properties ... | [
"GO:0005576"
] | [
"extracellular region"
] | [
"cellular_component"
] | 1 | [
"PRINTS"
] | [
"PR00282"
] | [
"CYTOTOXIN"
] | [
151
] | 1 | [] | [] | [] | 0 | [
"1cb9",
"1ccq",
"1cdt",
"1chv",
"1cre",
"1crf",
"1cvo",
"1cxn",
"1cxo",
"1ffj",
"1h0j",
"1i02",
"1kbs",
"1kbt",
"1kxi",
"1rl5",
"1tgx",
"1ug4",
"1xt3",
"1zad",
"2bhi",
"2ccx",
"2cdx",
"2crs",
"2crt",
"2vlw",
"3fev",
"3neq",
"3plc",
"3vts",
"4om4",
"4om5"... | 47 | [
"PUB00003395",
"PUB00030711",
"PUB00074541",
"PUB00074544",
"PUB00074547",
"PUB00097875"
] | [
"6433031",
"15584897",
"22649646",
"24180277",
"25349711",
"30804211"
] | [
"Classification of elapid snake neurotoxins and cytotoxins according to chain length: evolutionary implications.",
"Interaction of three-finger toxins with phospholipid membranes: comparison of S- and P-type cytotoxins.",
"Anionic lipids: determinants of binding cytotoxins from snake venom on the surface of cel... | [
1984,
2005,
2010,
2013,
2014,
2019
] | 6 | [
"IPR003571"
] | [] | 1 | 0 | 1 | [
"Elapidae"
] | [
151
] | 1 | [] | [] | 0 | true | Family | Snake cytotoxin, cobra-type | Snake cytotoxin, cobra-type | Cytotoxin_Cobra | 2 |
IPR003574 | 3,574 | Interleukin-6-like | IL-6-like | Family | 1,134 | false | false | This entry represents interleukin-6 (IL6), also refered to as B-cell stimulatory factor-2 (BSF-2) and interferon beta-2, it is a cytokine involved in a wide variety of biological functions [ ]. It plays an essential role in the final differentiation of B-cells into IG-secreting cells, as well as inducing myeloma/plasma... | [
"GO:0005138",
"GO:0030154",
"GO:0005615"
] | [
"interleukin-6 receptor binding",
"cell differentiation",
"extracellular space"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PANTHER"
] | [
"PF00489",
"PTHR48494"
] | [
"IL6",
""
] | [
1081,
1113
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1059683",
"R-BTA-110056",
"R-BTA-112411",
"R-BTA-381426",
"R-BTA-8957275",
"R-GGA-1059683",
"R-GGA-381426",
"R-GGA-8957275",
"R-HSA-1059683",
"R-HSA-110056",
"R-HSA-112411",
"R-HSA-2559582",
"R-HSA-381426",
"R-HSA-6783783",
"R-HSA-6785807",
"R-HSA-8853884",
"R-HSA-8957275",
... | [
"REACTOME:R-BTA-1059683",
"REACTOME:R-BTA-110056",
"REACTOME:R-BTA-112411",
"REACTOME:R-BTA-381426",
"REACTOME:R-BTA-8957275",
"REACTOME:R-GGA-1059683",
"REACTOME:R-GGA-381426",
"REACTOME:R-GGA-8957275",
"REACTOME:R-HSA-1059683",
"REACTOME:R-HSA-110056",
"REACTOME:R-HSA-112411",
"REACTOME:R-HS... | 29 | [
"1alu",
"1i1r",
"1il6",
"1p9m",
"2il6",
"2l3y",
"4cni",
"4j4l",
"4ni7",
"4ni9",
"4o9h",
"4zs7",
"5fuc",
"7nxz",
"8d82",
"8qy5",
"8qy6",
"8ywq",
"8ywr"
] | 19 | [
"PUB00001608",
"PUB00003997",
"PUB00153102"
] | [
"2037043",
"3491322",
"22521915"
] | [
"Evidence for the importance of a positive charge and an alpha-helical structure of the C-terminus for biological activity of human IL-6.",
"Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin.",
"The KSHV viral IL-6 homolog is sufficient to induce blood ... | [
1991,
1986,
2012
] | 3 | [
"IPR030474"
] | [] | 1 | 0 | 1 | [
"Gnathostomata",
"Rhadinovirus"
] | [
1115,
19
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
16,
7,
3
] | 4 | true | Family | Interleukin-6-like | Interleukin-6-like | IL-6-like | 9 |
IPR003578 | 3,578 | Small GTPase Rho | Small_GTPase_Rho | Family | 51,615 | false | false | This entry represents the Rho subfamily of Ras-like small GTPases. The small GTPase-like protein LIP2 (light insensitive period 2) from Arabidopsis thaliana is implicated in control of the plant circadian rhythm [ ]. The crystal structures of a number of the members of this entry have been determined: Rnd3/RhoE [ ], Rh... | [
"GO:0005525",
"GO:0007264"
] | [
"GTP binding",
"small GTPase-mediated signal transduction"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PANTHER"
] | [
"PTHR24072"
] | [
""
] | [
51615
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-114604",
"R-BTA-1222556",
"R-BTA-1257604",
"R-BTA-182971",
"R-BTA-193634",
"R-BTA-198203",
"R-BTA-2029482",
"R-BTA-209563",
"R-BTA-2173791",
"R-BTA-389359",
"R-BTA-392451",
"R-BTA-3928662",
"R-BTA-3928663",
"R-BTA-4086400",
"R-BTA-416482",
"R-BTA-416550",
"R-BTA-416572",
"R-... | [
"REACTOME:R-BTA-114604",
"REACTOME:R-BTA-1222556",
"REACTOME:R-BTA-1257604",
"REACTOME:R-BTA-182971",
"REACTOME:R-BTA-193634",
"REACTOME:R-BTA-198203",
"REACTOME:R-BTA-2029482",
"REACTOME:R-BTA-209563",
"REACTOME:R-BTA-2173791",
"REACTOME:R-BTA-389359",
"REACTOME:R-BTA-392451",
"REACTOME:R-BTA... | 578 | [
"1a2b",
"1a4r",
"1aje",
"1am4",
"1an0",
"1cc0",
"1cee",
"1cf4",
"1cxz",
"1doa",
"1dpf",
"1ds6",
"1e0a",
"1e96",
"1ees",
"1foe",
"1ftn",
"1g4u",
"1grn",
"1gwn",
"1gzs",
"1he1",
"1hh4",
"1i4d",
"1i4l",
"1i4t",
"1ki1",
"1kmq",
"1kz7",
"1kzg",
"1lb1",
"1m7b"... | 287 | [
"PUB00000348",
"PUB00004087",
"PUB00015117",
"PUB00023196",
"PUB00025351",
"PUB00027242",
"PUB00028136",
"PUB00052600",
"PUB00083222"
] | [
"2029511",
"1898771",
"11995995",
"2196171",
"9846874",
"12163169",
"11927263",
"2122258",
"17683937"
] | [
"The ras protein family: evolutionary tree and role of conserved amino acids.",
"The GTPase superfamily: conserved structure and molecular mechanism.",
"Structure of small G proteins and their regulators.",
"Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implicat... | [
1991,
1991,
2001,
1990,
1998,
2002,
2002,
1990,
2007
] | 9 | [
"IPR001806"
] | [
"IPR037874",
"IPR041842",
"IPR041843",
"IPR042734"
] | 1 | 4 | 0 | [
"Eukaryota",
"Orpheovirus IHUMI-LCC2",
"Pseudomonadati"
] | [
51609,
1,
5
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
42,
8,
80,
15,
101,
77,
10,
23,
79,
7,
7,
61
] | 12 | true | Family | Small GTPase Rho | Small GTPase Rho | Small_GTPase_Rho | 5 |
IPR003583 | 3,583 | Helix-hairpin-helix DNA-binding motif, class 1 | Hlx-hairpin-Hlx_DNA-bd_motif | Domain | 83,720 | false | false | The HhH motif is a stretch of approximately 20 amino acids that is present in prokaryotic and eukaryotic non-sequence-specific DNA binding proteins [ , , ]. The HhH motif is similar to, but distinct from, the HtH motif. Both of these motifs have two helices connected by a short turn. In the HtH motif the second helix b... | [
"GO:0003677",
"GO:0006281"
] | [
"DNA binding",
"DNA repair"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"SMART"
] | [
"SM00278"
] | [
"HhH1"
] | [
83720
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-110362",
"R-BTA-110373",
"R-BTA-110381",
"R-BTA-5649702",
"R-BTA-5651801",
"R-BTA-5689880",
"R-BTA-73930",
"R-DRE-110362",
"R-DRE-110373",
"R-DRE-5649702",
"R-DRE-73930",
"R-HSA-110362",
"R-HSA-110373",
"R-HSA-110381",
"R-HSA-2132295",
"R-HSA-5649702",
"R-HSA-5651801",
"R-HS... | [
"REACTOME:R-BTA-110362",
"REACTOME:R-BTA-110373",
"REACTOME:R-BTA-110381",
"REACTOME:R-BTA-5649702",
"REACTOME:R-BTA-5651801",
"REACTOME:R-BTA-5689880",
"REACTOME:R-BTA-73930",
"REACTOME:R-DRE-110362",
"REACTOME:R-DRE-110373",
"REACTOME:R-DRE-5649702",
"REACTOME:R-DRE-73930",
"REACTOME:R-HSA-1... | 42 | [
"1bdx",
"1bgx",
"1bpd",
"1bpe",
"1bpx",
"1bpy",
"1bpz",
"1c7y",
"1cuk",
"1d8l",
"1dgs",
"1hjp",
"1huo",
"1huz",
"1ixr",
"1jj2",
"1k73",
"1k8a",
"1k9m",
"1kc8",
"1kd1",
"1kft",
"1kqs",
"1m1k",
"1m90",
"1mq2",
"1mq3",
"1n8r",
"1nji",
"1pzn",
"1q7y",
"1q81"... | 568 | [
"PUB00004467",
"PUB00006160",
"PUB00006161",
"PUB00006162"
] | [
"8692686",
"9973609",
"7664751",
"9987128"
] | [
"The helix-hairpin-helix DNA-binding motif: a structural basis for non-sequence-specific recognition of DNA.",
"Conserved domains in DNA repair proteins and evolution of repair systems.",
"Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure.",
"ComEA is a DNA receptor for tran... | [
1996,
1999,
1995,
1999
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
3331,
75531,
3134,
67,
1657
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
1,
3,
4,
13,
4,
2,
10
] | 7 | true | Domain | Helix-hairpin-helix DNA-binding motif, class 1 | Helix-hairpin-helix DNA-binding motif, class 1 | Hlx-hairpin-Hlx_DNA-bd_motif | 5 |
IPR003585 | 3,585 | Neurexin/syndecan/glycophorin C | Neurexin-like | Domain | 21,741 | false | false | The putative band 4.1 homologues' binding motif is found in neurexins, syndecans and glycophorin C intracellular C-termini. Syndecans are cell surface proteoglycans and glycophorin C is a minor sialoglycoprotein in human erythrocyte membranes, which play an important role in regulating the stability of red cells. Synde... | [] | [] | [] | 0 | [
"SMART"
] | [
"SM00294"
] | [
"4.1m"
] | [
21741
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1971475",
"R-BTA-2022928",
"R-BTA-2024096",
"R-BTA-202733",
"R-BTA-3000170",
"R-BTA-381426",
"R-BTA-3928662",
"R-BTA-449836",
"R-BTA-8957275",
"R-BTA-975634",
"R-DME-1971475",
"R-DME-2022928",
"R-DME-2024096",
"R-DME-3000170",
"R-DME-381426",
"R-DME-3928662",
"R-DME-8957275",
... | [
"REACTOME:R-BTA-1971475",
"REACTOME:R-BTA-2022928",
"REACTOME:R-BTA-2024096",
"REACTOME:R-BTA-202733",
"REACTOME:R-BTA-3000170",
"REACTOME:R-BTA-381426",
"REACTOME:R-BTA-3928662",
"REACTOME:R-BTA-449836",
"REACTOME:R-BTA-8957275",
"REACTOME:R-BTA-975634",
"REACTOME:R-DME-1971475",
"REACTOME:R-... | 78 | [
"8g7y",
"8g7z",
"8g80",
"8g81"
] | 4 | [
"PUB00003015",
"PUB00024589"
] | [
"9582338",
"11456484"
] | [
"Solution structure of a syndecan-4 cytoplasmic domain and its interaction with phosphatidylinositol 4,5-bisphosphate.",
"Solution structure of the dimeric cytoplasmic domain of syndecan-4."
] | [
1998,
2001
] | 2 | [] | [
"IPR027789"
] | 0 | 1 | 0 | [
"Eukaryota",
"Kangiella spongicola"
] | [
21740,
1
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
290,
10,
73,
52,
70
] | 5 | true | Domain | Neurexin/syndecan/glycophorin C | Neurexin/syndecan/glycophorin C | Neurexin-like | 1 |
IPR003586 | 3,586 | Hint domain C-terminal | Hint_dom_C | Domain | 10,243 | false | false | This entry represents the C-terminal region of the hint domain. Hedgehog proteins are a family of secreted signal molecules required for embryonic cell differentiation. They are synthesised as inactive precursors with an N-terminal signalling domain linked to a C-terminal autoprocessing domain. The three-dimensional st... | [] | [] | [] | 0 | [
"SMART"
] | [
"SM00305"
] | [
"HintC"
] | [
10243
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-209338",
"R-DME-209471",
"R-DME-5358346",
"R-DME-5362798",
"R-DME-5632681",
"R-DRE-5358346",
"R-DRE-5362798",
"R-DRE-5632681",
"R-GGA-5358346",
"R-GGA-5362798",
"R-GGA-5632681",
"R-HSA-373080",
"R-HSA-5358346",
"R-HSA-5362768",
"R-HSA-5362798",
"R-HSA-5632681",
"R-HSA-5632684"... | [
"REACTOME:R-DME-209338",
"REACTOME:R-DME-209471",
"REACTOME:R-DME-5358346",
"REACTOME:R-DME-5362798",
"REACTOME:R-DME-5632681",
"REACTOME:R-DRE-5358346",
"REACTOME:R-DRE-5362798",
"REACTOME:R-DRE-5632681",
"REACTOME:R-GGA-5358346",
"REACTOME:R-GGA-5362798",
"REACTOME:R-GGA-5632681",
"REACTOME:... | 35 | [
"1at0",
"1mi8",
"2cw7",
"2cw8",
"2jmz",
"2jnq",
"2lqm",
"3ifj",
"4e2t",
"4e2u",
"4o1r",
"5bkh",
"5i0a",
"5k08",
"5o9i",
"5o9j",
"6fre",
"6frg",
"6frh",
"6rpp",
"6rpq",
"6td6",
"6tyy",
"7cfv",
"7e2i",
"7qss",
"7qst",
"7qsu",
"9cop",
"9hth"
] | 30 | [
"PUB00011705"
] | [
"9489693"
] | [
"Protein splicing of inteins and hedgehog autoproteolysis: structure, function, and evolution."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1436,
4117,
4158,
234,
298
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
12,
23,
1,
7,
6,
7,
1
] | 8 | true | Domain | Hint domain C-terminal | Hint domain C-terminal | Hint_dom_C | 9 |
IPR003587 | 3,587 | Hint domain N-terminal | Hint_dom_N | Domain | 19,723 | false | false | This entry represents the N-terminal region of the hint domain. Hedgehog proteins are a family of secreted signal molecules required for embryonic cell differentiation. They are synthesised as inactive precursors with an N-terminal signalling domain linked to a C-terminal autoprocessing domain. The three-dimensional st... | [] | [] | [] | 0 | [
"SMART"
] | [
"SM00306"
] | [
"HintN"
] | [
19723
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DDI-76061",
"R-DDI-76066",
"R-DME-209338",
"R-DME-209471",
"R-DME-5358346",
"R-DME-5362798",
"R-DME-5632681",
"R-DRE-5358346",
"R-DRE-5362798",
"R-DRE-5632681",
"R-GGA-5358346",
"R-GGA-5362798",
"R-GGA-5632681",
"R-HSA-373080",
"R-HSA-5358346",
"R-HSA-5362768",
"R-HSA-5362798",
... | [
"REACTOME:R-DDI-76061",
"REACTOME:R-DDI-76066",
"REACTOME:R-DME-209338",
"REACTOME:R-DME-209471",
"REACTOME:R-DME-5358346",
"REACTOME:R-DME-5362798",
"REACTOME:R-DME-5632681",
"REACTOME:R-DRE-5358346",
"REACTOME:R-DRE-5362798",
"REACTOME:R-DRE-5632681",
"REACTOME:R-GGA-5358346",
"REACTOME:R-GG... | 37 | [
"1am2",
"1at0",
"1dfa",
"1dq3",
"1ef0",
"1gpp",
"1jva",
"1lws",
"1lwt",
"1mi8",
"1vde",
"1zd7",
"1zde",
"2cw7",
"2cw8",
"2imz",
"2in0",
"2in8",
"2in9",
"2jmz",
"2jnq",
"2keq",
"2l8l",
"2lcj",
"2lqm",
"2lwy",
"3ifj",
"3igd",
"3nzm",
"4e2t",
"4e2u",
"4gig"... | 75 | [
"PUB00011705"
] | [
"9489693"
] | [
"Protein splicing of inteins and hedgehog autoproteolysis: structure, function, and evolution."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1728,
10916,
5899,
689,
491
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
12,
23,
1,
7,
6,
9,
2
] | 8 | true | Domain | Hint domain N-terminal | Hint domain N-terminal | Hint_dom_N | 5 |
IPR003591 | 3,591 | Leucine-rich repeat, typical subtype | Leu-rich_rpt_typical-subtyp | Repeat | 422,283 | false | false | Leucine-rich repeats (LRR) consist of 2-45 motifs of 20-30 amino acids in length that generally folds into an arc or horseshoe shape [ ]. LRRs occur in proteins ranging from viruses to eukaryotes, and appear to provide a structural framework for the formation of protein-protein interactions [ , ].Proteins containing LR... | [] | [] | [] | 0 | [
"SMART"
] | [
"SM00369"
] | [
"LRR_TYP"
] | [
422283
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-114608",
"R-BTA-1474228",
"R-BTA-168142",
"R-BTA-1971475",
"R-BTA-2022854",
"R-BTA-2022857",
"R-BTA-2022870",
"R-BTA-2022923",
"R-BTA-2024101",
"R-BTA-216083",
"R-BTA-3000178",
"R-BTA-5223345",
"R-BTA-5673000",
"R-BTA-5682910",
"R-BTA-6794361",
"R-BTA-8849932",
"R-CEL-177929",... | [
"REACTOME:R-BTA-114608",
"REACTOME:R-BTA-1474228",
"REACTOME:R-BTA-168142",
"REACTOME:R-BTA-1971475",
"REACTOME:R-BTA-2022854",
"REACTOME:R-BTA-2022857",
"REACTOME:R-BTA-2022870",
"REACTOME:R-BTA-2022923",
"REACTOME:R-BTA-2024101",
"REACTOME:R-BTA-216083",
"REACTOME:R-BTA-3000178",
"REACTOME:R... | 395 | [
"1d0b",
"1gwb",
"1h6t",
"1h6u",
"1m0z",
"1m10",
"1m9s",
"1o6s",
"1o6t",
"1o6v",
"1ook",
"1otm",
"1otn",
"1oto",
"1ozn",
"1p8t",
"1p8v",
"1p9a",
"1qyy",
"1sq0",
"1u0n",
"1w8a",
"1xcd",
"1xec",
"1xeu",
"1xku",
"1ziw",
"2a0z",
"2ft3",
"2id5",
"2o6q",
"2o6r"... | 584 | [
"PUB00001625",
"PUB00001898",
"PUB00007147",
"PUB00007148",
"PUB00017058",
"PUB00094376"
] | [
"1657640",
"2176636",
"11751054",
"11967365",
"14747988",
"21606681"
] | [
"A leucine-rich repeat peptide derived from the Drosophila Toll receptor forms extended filaments with a beta-sheet structure.",
"slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains.",
"The leucine-rich repeat as a protein reco... | [
1991,
1990,
2001,
2002,
2004,
2011
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
98,
14211,
407119,
121,
734
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
964,
56,
742,
281,
584,
428,
9,
1039,
608,
4,
6,
786
] | 12 | true | Repeat | Leucine-rich repeat, typical subtype | Leucine-rich repeat, typical subtype | Leu-rich_rpt_typical-subtyp | 7 |
IPR003593 | 3,593 | AAA+ ATPase domain | AAA+_ATPase | Domain | 3,558,898 | false | false | This entry represents the AAA+ ATPase domain found in a range of proteins, including Holliday junction ATP-dependent DNA helicase RuvB from Mycobacterium sp, ATP synthases, and related ATP-dependent proteins. The proteins in this superfamily are characterised by the structural conservation of a central ATPase domain of... | [] | [] | [] | 0 | [
"SMART"
] | [
"SM00382"
] | [
"AAA"
] | [
3558898
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-110312",
"R-BTA-110314",
"R-BTA-110320",
"R-BTA-1169091",
"R-BTA-1234176",
"R-BTA-1236978",
"R-BTA-1660661",
"R-BTA-174084",
"R-BTA-174154",
"R-BTA-174178",
"R-BTA-174184",
"R-BTA-174411",
"R-BTA-176187",
"R-BTA-1799339",
"R-BTA-187577",
"R-BTA-189483",
"R-BTA-195253",
"R-BT... | [
"REACTOME:R-BTA-110312",
"REACTOME:R-BTA-110314",
"REACTOME:R-BTA-110320",
"REACTOME:R-BTA-1169091",
"REACTOME:R-BTA-1234176",
"REACTOME:R-BTA-1236978",
"REACTOME:R-BTA-1660661",
"REACTOME:R-BTA-174084",
"REACTOME:R-BTA-174154",
"REACTOME:R-BTA-174178",
"REACTOME:R-BTA-174184",
"REACTOME:R-BTA... | 1,207 | [
"1b0u",
"1bmf",
"1cow",
"1d2n",
"1do0",
"1do2",
"1e1q",
"1e1r",
"1e32",
"1e69",
"1e79",
"1e94",
"1efr",
"1f3o",
"1f48",
"1ffh",
"1fnn",
"1fts",
"1fx0",
"1g18",
"1g19",
"1g29",
"1g3i",
"1g41",
"1g4a",
"1g4b",
"1g6h",
"1g8p",
"1g9x",
"1h8e",
"1h8h",
"1hqc"... | 3,432 | [
"PUB00005841",
"PUB00057226",
"PUB00057227"
] | [
"9927482",
"11473577",
"18466635"
] | [
"AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes.",
"AAA+ superfamily ATPases: common structure--diverse function.",
"The AAA+ superfamily of functionally diverse proteins."
] | [
1999,
2001,
2008
] | 3 | [] | [
"IPR003439",
"IPR008824",
"IPR034348",
"IPR045427",
"IPR045735"
] | 0 | 5 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"other sequences",
"unclassified sequences"
] | [
58555,
2751369,
703073,
11689,
25,
34187
] | 6 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
1694,
142,
589,
290,
119,
582,
368,
100,
803,
569,
82,
71,
1973
] | 13 | true | Domain | AAA+ ATPase domain | AAA+ ATPase domain | AAA+_ATPase | 9 |
IPR003594 | 3,594 | Histidine kinase/HSP90-like ATPase domain | HATPase_dom | Domain | 1,189,955 | false | false | This domain is found in several ATP-binding proteins, including: histidine kinase [ ], DNA gyrase B, topoisomerases [ ], heat shock protein HSP90 [ , , ], phytochrome-like ATPases and DNA mismatch repair proteins. The fold of this domain consists of two layers, α/β, which contains an 8-stranded mixed β-sheet. | [] | [] | [] | 0 | [
"PFAM",
"PFAM",
"SMART"
] | [
"PF02518",
"PF13581",
"SM00387"
] | [
"HATPase_c",
"HATPase_c_2",
"HATPase_c"
] | [
1079780,
84572,
1019981
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1227986",
"R-BTA-1474151",
"R-BTA-1679131",
"R-BTA-168928",
"R-BTA-2029482",
"R-BTA-203615",
"R-BTA-2565942",
"R-BTA-3371497",
"R-BTA-3371511",
"R-BTA-3371568",
"R-BTA-3371571",
"R-BTA-380259",
"R-BTA-380270",
"R-BTA-380284",
"R-BTA-380320",
"R-BTA-381426",
"R-BTA-399954",
"... | [
"REACTOME:R-BTA-1227986",
"REACTOME:R-BTA-1474151",
"REACTOME:R-BTA-1679131",
"REACTOME:R-BTA-168928",
"REACTOME:R-BTA-2029482",
"REACTOME:R-BTA-203615",
"REACTOME:R-BTA-2565942",
"REACTOME:R-BTA-3371497",
"REACTOME:R-BTA-3371511",
"REACTOME:R-BTA-3371568",
"REACTOME:R-BTA-3371571",
"REACTOME:... | 311 | [
"1a4h",
"1ah6",
"1ah8",
"1aj6",
"1am1",
"1amw",
"1b3q",
"1bgq",
"1bxd",
"1byq",
"1ei1",
"1gjv",
"1gkx",
"1gkz",
"1i58",
"1i59",
"1i5a",
"1i5b",
"1i5c",
"1i5d",
"1id0",
"1jm6",
"1kij",
"1kzn",
"1l0o",
"1mu5",
"1mx0",
"1osf",
"1pvg",
"1qy8",
"1qye",
"1qzr"... | 1,081 | [
"PUB00022659",
"PUB00030541",
"PUB00031400",
"PUB00031884",
"PUB00031942"
] | [
"15105144",
"15157101",
"15292259",
"14718169",
"15217611"
] | [
"Crystal structures of Escherichia coli topoisomerase IV ParE subunit (24 and 43 kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyrase.",
"Crystal structure of the C-terminal domain of the two-component system transmitter protein nitrogen regulator II (N... | [
2004,
2004,
2004,
2004,
2004
] | 5 | [] | [
"IPR020575",
"IPR032834",
"IPR044082",
"IPR044767",
"IPR047963",
"IPR047965",
"IPR058126",
"IPR058619"
] | 0 | 8 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"plasmids",
"unclassified sequences"
] | [
17487,
1088620,
72435,
552,
2,
10859
] | 6 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
149,
8,
20,
9,
32,
57,
42,
17,
94,
43,
5,
5,
261
] | 13 | true | Domain | Histidine kinase/HSP90-like ATPase domain | Histidine kinase/HSP90-like ATPase domain | HATPase_dom | 9 |
IPR003597 | 3,597 | Immunoglobulin C1-set | Ig_C1-set | Domain | 86,821 | false | false | The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains and two heavy chains linked by disulphide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains: alpha, delta, epsilon, ... | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF07654",
"SM00407"
] | [
"C1-set",
"IGc1"
] | [
85528,
82403
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1236974",
"R-BTA-1236977",
"R-BTA-198933",
"R-BTA-2424491",
"R-BTA-6798695",
"R-BTA-983170",
"R-CFA-983170",
"R-DRE-1236974",
"R-DRE-1236977",
"R-DRE-2132295",
"R-DRE-6798695",
"R-DRE-983170",
"R-GGA-1236974",
"R-GGA-1236977",
"R-GGA-198933",
"R-GGA-2132263",
"R-GGA-2132286",
... | [
"REACTOME:R-BTA-1236974",
"REACTOME:R-BTA-1236977",
"REACTOME:R-BTA-198933",
"REACTOME:R-BTA-2424491",
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-983170",
"REACTOME:R-CFA-983170",
"REACTOME:R-DRE-1236974",
"REACTOME:R-DRE-1236977",
"REACTOME:R-DRE-2132295",
"REACTOME:R-DRE-6798695",
"REACTOME:R... | 145 | [
"12e8",
"15c8",
"1a0q",
"1a1m",
"1a1n",
"1a1o",
"1a3l",
"1a3r",
"1a4j",
"1a4k",
"1a5f",
"1a6a",
"1a6t",
"1a6z",
"1a8j",
"1a9b",
"1a9e",
"1acy",
"1ad0",
"1ad9",
"1adq",
"1ae6",
"1afv",
"1agb",
"1agc",
"1agd",
"1age",
"1agf",
"1ahw",
"1ai1",
"1aif",
"1aj7"... | 8,833 | [
"PUB00010610",
"PUB00014840",
"PUB00015110",
"PUB00015111",
"PUB00015113",
"PUB00027656"
] | [
"11377196",
"9417933",
"15327963",
"9597133",
"12637770",
"10698639"
] | [
"Mapping the folding pathway of an immunoglobulin domain: structural detail from Phi value analysis and movement of the transition state.",
"Sequence profiles of immunoglobulin and immunoglobulin-like domains.",
"Protein--protein recognition: juxtaposition of domain and interface cores in immunoglobulins and ot... | [
2001,
1997,
2004,
1998,
2003,
2000
] | 6 | [
"IPR007110"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Metazoa",
"Viruses",
"bird metagenome"
] | [
22,
86640,
154,
5
] | 4 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
177,
2,
17613,
625,
443
] | 5 | true | Domain | Immunoglobulin C1-set | Immunoglobulin C1-set | Ig_C1-set | 5 |
IPR003598 | 3,598 | Immunoglobulin subtype 2 | Ig_sub2 | Domain | 376,764 | false | false | This entry represents a subtype of the immunoglobulin domain, and is found in a diverse range of protein families that includes glycoproteins, fibroblast growth factor receptors, vascular endothelial growth factor receptors, interleukin-6 receptor, and neural cell adhesion molecules [ ]. The basic structure of immunogl... | [] | [] | [] | 0 | [
"SMART"
] | [
"SM00408"
] | [
"IGc2"
] | [
376764
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-114608",
"R-BTA-163125",
"R-BTA-198933",
"R-BTA-202424",
"R-BTA-202427",
"R-BTA-202430",
"R-BTA-202433",
"R-BTA-202733",
"R-BTA-216083",
"R-BTA-2173791",
"R-BTA-388844",
"R-BTA-389948",
"R-BTA-420029",
"R-BTA-445355",
"R-BTA-5627123",
"R-BTA-5690714",
"R-BTA-6798695",
"R-BTA... | [
"REACTOME:R-BTA-114608",
"REACTOME:R-BTA-163125",
"REACTOME:R-BTA-198933",
"REACTOME:R-BTA-202424",
"REACTOME:R-BTA-202427",
"REACTOME:R-BTA-202430",
"REACTOME:R-BTA-202433",
"REACTOME:R-BTA-202733",
"REACTOME:R-BTA-216083",
"REACTOME:R-BTA-2173791",
"REACTOME:R-BTA-388844",
"REACTOME:R-BTA-38... | 833 | [
"1bih",
"1bm3",
"1bog",
"1bql",
"1c08",
"1cdh",
"1cdi",
"1cdj",
"1cdu",
"1cdy",
"1cfn",
"1cfq",
"1cfs",
"1cft",
"1cs6",
"1cvs",
"1djs",
"1dqj",
"1dqm",
"1dqq",
"1e07",
"1e0o",
"1egj",
"1epf",
"1ev2",
"1evt",
"1f2q",
"1f42",
"1f45",
"1f6a",
"1f97",
"1fcg"... | 1,334 | [
"PUB00010610",
"PUB00014133",
"PUB00014840",
"PUB00015110",
"PUB00027656"
] | [
"11377196",
"14705960",
"9417933",
"15327963",
"10698639"
] | [
"Mapping the folding pathway of an immunoglobulin domain: structural detail from Phi value analysis and movement of the transition state.",
"Evolutionary families of peptidase inhibitors.",
"Sequence profiles of immunoglobulin and immunoglobulin-like domains.",
"Protein--protein recognition: juxtaposition of ... | [
2001,
2004,
1997,
2004,
2000
] | 5 | [
"IPR007110"
] | [
"IPR047101"
] | 1 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
369,
376242,
122,
31
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
130,
2144,
504,
1324,
743,
1015
] | 6 | true | Domain | Immunoglobulin subtype 2 | Immunoglobulin subtype 2 | Ig_sub2 | 9 |
IPR003599 | 3,599 | Immunoglobulin domain subtype | Ig_sub | Domain | 602,349 | false | false | This entry represents a subtype of the immunoglobulin domain which is found in a group of proteins that includes: Cell surface receptors containing an immunoglobulin domain. Killer cell inhibitory receptors. Cell adhesion molecules. The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains ... | [] | [] | [] | 0 | [
"SMART"
] | [
"SM00409"
] | [
"IG"
] | [
602349
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-114608",
"R-BTA-163125",
"R-BTA-1971475",
"R-BTA-198933",
"R-BTA-2022870",
"R-BTA-2022923",
"R-BTA-2024101",
"R-BTA-202733",
"R-BTA-2029481",
"R-BTA-2029482",
"R-BTA-2029485",
"R-BTA-216083",
"R-BTA-2173791",
"R-BTA-3000178",
"R-BTA-381426",
"R-BTA-388844",
"R-BTA-420029",
"... | [
"REACTOME:R-BTA-114608",
"REACTOME:R-BTA-163125",
"REACTOME:R-BTA-1971475",
"REACTOME:R-BTA-198933",
"REACTOME:R-BTA-2022870",
"REACTOME:R-BTA-2022923",
"REACTOME:R-BTA-2024101",
"REACTOME:R-BTA-202733",
"REACTOME:R-BTA-2029481",
"REACTOME:R-BTA-2029482",
"REACTOME:R-BTA-2029485",
"REACTOME:R-... | 955 | [
"12e8",
"15c8",
"1a0q",
"1a14",
"1a2y",
"1a3l",
"1a3r",
"1a4j",
"1a4k",
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"1ad9",
"1adq",
"1ae6",
"1afv",
"1ah1",
"1ahw",
"1ai1",
"1aif",
"1aj7"... | 12,290 | [
"PUB00010610",
"PUB00014840",
"PUB00015110",
"PUB00027656"
] | [
"11377196",
"9417933",
"15327963",
"10698639"
] | [
"Mapping the folding pathway of an immunoglobulin domain: structural detail from Phi value analysis and movement of the transition state.",
"Sequence profiles of immunoglobulin and immunoglobulin-like domains.",
"Protein--protein recognition: juxtaposition of domain and interface cores in immunoglobulins and ot... | [
2001,
1997,
2004,
2000
] | 4 | [
"IPR007110"
] | [
"IPR013106",
"IPR047102",
"IPR055229",
"IPR055238",
"IPR056386"
] | 1 | 5 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
48,
3185,
597880,
1153,
83
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
134,
3348,
520,
19454,
2261,
2067
] | 6 | true | Domain | Immunoglobulin domain subtype | Immunoglobulin domain subtype | Ig_sub | 8 |
IPR003602 | 3,602 | DNA topoisomerase, type IA, DNA-binding domain | Topo_IA_DNA-bd_dom | Domain | 57,580 | false | false | DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical turns) by catalysing transient single-or double-strand breaks, crossing the strands through one another, then resealing the breaks [ ]. These enzymes have several functions: to remove DNA supercoi... | [
"GO:0003677",
"GO:0003916",
"GO:0006265"
] | [
"DNA binding",
"DNA topoisomerase activity",
"DNA topological change"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"SMART"
] | [
"SM00437"
] | [
"TOP1Ac"
] | [
57580
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"5.6.2.1",
"R-CEL-5693607",
"R-HSA-5685938",
"R-HSA-5685942",
"R-HSA-5693554",
"R-HSA-5693568",
"R-HSA-5693579",
"R-HSA-5693607",
"R-HSA-5693616",
"R-HSA-6804756",
"R-HSA-69473",
"R-HSA-912446",
"R-HSA-9701192",
"R-HSA-9704331",
"R-HSA-9704646",
"R-HSA-9709570",
"R-HSA-9709603",
"R... | [
"EC:5.6.2.1",
"REACTOME:R-CEL-5693607",
"REACTOME:R-HSA-5685938",
"REACTOME:R-HSA-5685942",
"REACTOME:R-HSA-5693554",
"REACTOME:R-HSA-5693568",
"REACTOME:R-HSA-5693579",
"REACTOME:R-HSA-5693607",
"REACTOME:R-HSA-5693616",
"REACTOME:R-HSA-6804756",
"REACTOME:R-HSA-69473",
"REACTOME:R-HSA-912446... | 26 | [
"1cy0",
"1cy1",
"1cy2",
"1cy4",
"1cy6",
"1cy7",
"1cy8",
"1cy9",
"1cyy",
"1d6m",
"1ecl",
"1gku",
"1gl9",
"1i7d",
"1mw8",
"1mw9",
"2gai",
"2gaj",
"2o19",
"2o54",
"2o59",
"2o5c",
"2o5e",
"3pwt",
"3px7",
"4cgy",
"4cht",
"4ddt",
"4ddu",
"4ddv",
"4ddw",
"4ddx"... | 65 | [
"PUB00005230",
"PUB00005437",
"PUB00016842",
"PUB00020793",
"PUB00020794",
"PUB00020796",
"PUB00020799",
"PUB00081702",
"PUB00081703",
"PUB00081704",
"PUB00081705"
] | [
"9488644",
"7770916",
"11395412",
"12596227",
"12042765",
"14604525",
"10574789",
"21087076",
"20644584",
"17722649",
"17293019"
] | [
"Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.",
"The mechanisms of DNA topoisomerases.",
"DNA topoisomerases: structure, function, and mechanism.",
"Phylogenomics of type II DNA topoisomerases.",
"Cellular roles of DNA topoisomerases: a molecular perspective.",... | [
1998,
1995,
2001,
2003,
2002,
2003,
1999,
2010,
2010,
2007,
2007
] | 11 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"plasmids",
"unclassified sequences"
] | [
1265,
46128,
9240,
58,
9,
880
] | 6 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
19,
3,
3,
5,
2,
6,
12,
1,
9,
3,
1,
1,
59
] | 13 | true | Domain | DNA topoisomerase, type IA, DNA-binding domain | DNA topoisomerase, type IA, DNA-binding domain | Topo_IA_DNA-bd_dom | 4 |
IPR003603 | 3,603 | U2A'/phosphoprotein 32 family A, C-terminal | U2A'_phosphoprotein32A_C | Domain | 9,208 | false | false | This motif occurs C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins. Examples from the metazoa are described as either "Acidic leucine-rich nuclear phosphoprotein 32 family member A" or have been characterised as U2A', the protein that interacts with U2B'' facilitating the interac... | [] | [] | [] | 0 | [
"SMART"
] | [
"SM00446"
] | [
"LRRcap"
] | [
9208
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-450520",
"R-HSA-2565942",
"R-HSA-380259",
"R-HSA-380270",
"R-HSA-380284",
"R-HSA-380320",
"R-HSA-450520",
"R-HSA-5620912",
"R-HSA-72163",
"R-HSA-8854518",
"R-HSA-8950505",
"R-MMU-2565942",
"R-MMU-380259",
"R-MMU-380270",
"R-MMU-380284",
"R-MMU-380320",
"R-MMU-5620912",
"R-MM... | [
"REACTOME:R-BTA-450520",
"REACTOME:R-HSA-2565942",
"REACTOME:R-HSA-380259",
"REACTOME:R-HSA-380270",
"REACTOME:R-HSA-380284",
"REACTOME:R-HSA-380320",
"REACTOME:R-HSA-450520",
"REACTOME:R-HSA-5620912",
"REACTOME:R-HSA-72163",
"REACTOME:R-HSA-8854518",
"REACTOME:R-HSA-8950505",
"REACTOME:R-MMU-... | 19 | [
"1a9n",
"2ell",
"2je0",
"2je1",
"2rr6",
"4xos",
"5gmk",
"5lj3",
"5lj5",
"5mq0",
"5mqf",
"5nrl",
"5o9z",
"5wsg",
"5xjc",
"5y88",
"5ylz",
"5yzg",
"5z56",
"5z57",
"5z58",
"5zwm",
"5zwo",
"6ah0",
"6ahd",
"6bk8",
"6exn",
"6ff7",
"6g90",
"6hkw",
"6icz",
"6id0"... | 93 | [
"PUB00009402",
"PUB00033211"
] | [
"9716128",
"9799242"
] | [
"Crystal structure of the spliceosomal U2B\"-U2A' protein complex bound to a fragment of U2 small nuclear RNA.",
"The yeast U2A'/U2B complex is required for pre-spliceosome formation."
] | [
1998,
1998
] | 2 | [] | [] | 0 | 0 | null | [
"Chryseobacterium fistulae",
"Eukaryota"
] | [
1,
9207
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
7,
5,
10,
23,
12,
28,
1,
1,
3
] | 9 | true | Domain | U2A'/phosphoprotein 32 family A, C-terminal | U2A'/phosphoprotein 32 family A, C-terminal | U2A'_phosphoprotein32A_C | 7 |
IPR003604 | 3,604 | Matrin/U1-C-like, C2H2-type zinc finger | Matrin/U1-like-C_Znf_C2H2 | Domain | 66,889 | false | false | Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt b... | [
"GO:0003676",
"GO:0008270"
] | [
"nucleic acid binding",
"zinc ion binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"SMART"
] | [
"SM00451"
] | [
"ZnF_U1"
] | [
66889
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-72163",
"R-CFA-72163",
"R-HSA-381340",
"R-HSA-429947",
"R-HSA-6781823",
"R-HSA-6781827",
"R-HSA-6782135",
"R-HSA-6782210",
"R-HSA-6782315",
"R-HSA-6787450",
"R-HSA-6804114",
"R-HSA-6804116",
"R-HSA-6804759",
"R-HSA-69895",
"R-HSA-72163",
"R-HSA-8941855",
"R-HSA-9819196",
"R-... | [
"REACTOME:R-BTA-72163",
"REACTOME:R-CFA-72163",
"REACTOME:R-HSA-381340",
"REACTOME:R-HSA-429947",
"REACTOME:R-HSA-6781823",
"REACTOME:R-HSA-6781827",
"REACTOME:R-HSA-6782135",
"REACTOME:R-HSA-6782210",
"REACTOME:R-HSA-6782315",
"REACTOME:R-HSA-6787450",
"REACTOME:R-HSA-6804114",
"REACTOME:R-HS... | 33 | [
"1zr9",
"1zu1",
"2mkd",
"2mkn",
"2vrd",
"3cw1",
"3jct",
"4dgw",
"4pjo",
"5apn",
"5apo",
"5gm6",
"5nrl",
"5o9z",
"5z56",
"5z57",
"5z58",
"5zwm",
"5zwn",
"5zwo",
"6ah0",
"6ahd",
"6ff4",
"6ff7",
"6ft6",
"6g90",
"6lqm",
"6lsr",
"6lss",
"6lu8",
"6m62",
"6n7p"... | 127 | [
"PUB00014077",
"PUB00031914",
"PUB00035804",
"PUB00035805",
"PUB00035806",
"PUB00035807",
"PUB00035808",
"PUB00035809",
"PUB00035811",
"PUB00035812",
"PUB00035823",
"PUB00043274"
] | [
"12665246",
"15312772",
"17210253",
"15963892",
"15718139",
"10529348",
"11361095",
"10664601",
"10940247",
"11179890",
"9826776",
"18253864"
] | [
"Zinc fingers--folds for many occasions.",
"The structure and biochemical properties of the human spliceosomal protein U1C.",
"Sticky fingers: zinc-fingers as protein-recognition motifs.",
"Multiple modes of RNA recognition by zinc finger proteins.",
"Zinc finger proteins: getting a grip on RNA.",
"Zinc f... | [
2002,
2004,
2007,
2005,
2005,
1999,
2001,
2000,
2000,
2001,
1998,
2008
] | 12 | [
"IPR013087"
] | [
"IPR000690"
] | 1 | 1 | 0 | [
"Eukaryota",
"Viruses",
"viral metagenome"
] | [
66865,
8,
16
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
83,
14,
145,
25,
115,
94,
8,
44,
135,
6,
8,
92
] | 12 | true | Domain | Matrin/U1-C-like, C2H2-type zinc finger | Matrin/U1-C-like, C2H2-type zinc finger | Matrin/U1-like-C_Znf_C2H2 | 5 |
IPR003605 | 3,605 | GS domain | GS_dom | Domain | 11,072 | false | false | Transforming growth factor beta (TGF-beta) is a member of a large family of secreted growth factors of central importance in eukaryotic development and homeostasis. Members of this family, which includes the activins, inhibins and bone morphogenic proteins (BMPs), bind to receptors that consist of two transmembrane ser... | [
"GO:0004675",
"GO:0005524",
"GO:0006468",
"GO:0016020"
] | [
"transmembrane receptor protein serine/threonine kinase activity",
"ATP binding",
"protein phosphorylation",
"membrane"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF08515",
"PS51256",
"SM00467"
] | [
"TGF_beta_GS",
"GS",
"GS"
] | [
10817,
11042,
10271
] | 3 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.11.30",
"PDOC51256",
"R-BTA-2173788",
"R-BTA-2173789",
"R-BTA-2173791",
"R-BTA-5689880",
"R-BTA-9839389",
"R-CEL-201451",
"R-CEL-2173788",
"R-CEL-2173789",
"R-CEL-2173791",
"R-DME-1502540",
"R-DME-2173788",
"R-DME-2173789",
"R-DME-2173791",
"R-DME-5689880",
"R-HSA-1181150",
"R... | [
"EC:2.7.11.30",
"PROSITEDOC:PDOC51256",
"REACTOME:R-BTA-2173788",
"REACTOME:R-BTA-2173789",
"REACTOME:R-BTA-2173791",
"REACTOME:R-BTA-5689880",
"REACTOME:R-BTA-9839389",
"REACTOME:R-CEL-201451",
"REACTOME:R-CEL-2173788",
"REACTOME:R-CEL-2173789",
"REACTOME:R-CEL-2173791",
"REACTOME:R-DME-15025... | 44 | [
"1b6c",
"1ias",
"1py5",
"2x7o",
"3faa",
"3h9r",
"3kcf",
"3mdy",
"4c02",
"6eix",
"6i1s",
"8pod",
"8yhf",
"9d8e",
"9d8f",
"9d8z",
"9rda"
] | 17 | [
"PUB00021804",
"PUB00023523"
] | [
"11583628",
"10025408"
] | [
"The TGF beta receptor activation process: an inhibitor- to substrate-binding switch.",
"Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12."
] | [
2001,
1999
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
6,
11066
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
39,
19,
32,
22,
33
] | 6 | true | Domain | GS domain | GS domain | GS_dom | 8 |
IPR003607 | 3,607 | HD/PDEase domain | HD/PDEase_dom | Domain | 275,127 | false | false | This entry represents the HD domain, which is found in a superfamily of enzymes with a predicted or known phosphohydrolase activity. It also represents a related phosphodiesterase (PDEase) domain that is found in eukaryotic 3',5'-cGMP phosphodiesterase ( ), which is located in photoreceptor outer segments and it is lig... | [] | [] | [] | 0 | [
"SMART",
"CDD"
] | [
"SM00471",
"cd00077"
] | [
"HDc",
"HDc"
] | [
228615,
254730
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-111957",
"R-BTA-418457",
"R-BTA-418555",
"R-BTA-445355",
"R-BTA-8956319",
"R-BTA-9013422",
"R-CEL-111957",
"R-CEL-165160",
"R-CEL-180024",
"R-CEL-418457",
"R-CEL-418555",
"R-CEL-8956319",
"R-CEL-9860927",
"R-CFA-2485179",
"R-CFA-2514859",
"R-CFA-4086398",
"R-CFA-418457",
"R-... | [
"REACTOME:R-BTA-111957",
"REACTOME:R-BTA-418457",
"REACTOME:R-BTA-418555",
"REACTOME:R-BTA-445355",
"REACTOME:R-BTA-8956319",
"REACTOME:R-BTA-9013422",
"REACTOME:R-CEL-111957",
"REACTOME:R-CEL-165160",
"REACTOME:R-CEL-180024",
"REACTOME:R-CEL-418457",
"REACTOME:R-CEL-418555",
"REACTOME:R-CEL-8... | 69 | [
"1f0j",
"1mkd",
"1oyn",
"1ptw",
"1q9m",
"1rkp",
"1ro6",
"1ro9",
"1ror",
"1so2",
"1soj",
"1t9r",
"1t9s",
"1taz",
"1tb5",
"1tb7",
"1tbb",
"1tbf",
"1udt",
"1udu",
"1uho",
"1vj7",
"1xlx",
"1xlz",
"1xm4",
"1xm6",
"1xmu",
"1xmy",
"1xn0",
"1xom",
"1xon",
"1xoq"... | 911 | [
"PUB00112393"
] | [
"11008484"
] | [
"Cyclic nucleotide phosphodiesterases: relating structure and function."
] | [
2001
] | 1 | [] | [
"IPR002073",
"IPR006674",
"IPR037522"
] | 0 | 3 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
3952,
200927,
65814,
296,
4138
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
55,
22,
253,
36,
6,
103,
110,
4,
21,
165,
5,
1,
72
] | 13 | true | Domain | HD/PDEase domain | HD/PDEase domain | HD/PDEase_dom | 4 |
IPR003609 | 3,609 | PAN/Apple domain | Pan_app | Domain | 76,870 | false | false | Plasma kallikrein ( ) and coagulation factor XI ( ) are two related plasma serine proteases activated by factor XIIA and which share the same domain topology: an N-terminal region that contains four tandem repeats of about 90 amino acids and a C-terminal catalytic domain. The 90 amino-acid repeated domain contains 6 co... | [] | [] | [] | 0 | [
"PFAM",
"PFAM",
"PFAM",
"PROFILE",
"SMART"
] | [
"PF00024",
"PF08276",
"PF14295",
"PS50948",
"SM00473"
] | [
"PAN_1",
"PAN_2",
"PAN_4",
"PAN",
"PAN_AP"
] | [
28329,
32793,
8437,
62680,
39233
] | 5 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00376",
"R-BTA-140837",
"R-BTA-1592389",
"R-CFA-114608",
"R-CFA-1257604",
"R-CFA-5673001",
"R-CFA-6806942",
"R-CFA-6807004",
"R-CFA-6811558",
"R-CFA-8851805",
"R-CFA-8851907",
"R-CFA-8865999",
"R-CFA-8874081",
"R-CFA-8875513",
"R-CFA-8875555",
"R-CFA-8875656",
"R-CFA-8875791",
... | [
"PROSITEDOC:PDOC00376",
"REACTOME:R-BTA-140837",
"REACTOME:R-BTA-1592389",
"REACTOME:R-CFA-114608",
"REACTOME:R-CFA-1257604",
"REACTOME:R-CFA-5673001",
"REACTOME:R-CFA-6806942",
"REACTOME:R-CFA-6807004",
"REACTOME:R-CFA-6811558",
"REACTOME:R-CFA-8851805",
"REACTOME:R-CFA-8851907",
"REACTOME:R-... | 86 | [
"1bht",
"1gmn",
"1gmo",
"1gp9",
"1hky",
"1nk1",
"2hgf",
"2j8j",
"2j8l",
"2ll3",
"2ll4",
"2qj2",
"2qj4",
"2yil",
"2yio",
"2yip",
"3hmr",
"3hms",
"3hmt",
"3hn4",
"3mkp",
"3sp8",
"4a5t",
"4a5v",
"4d3c",
"4dur",
"4duu",
"4iua",
"5coe",
"5cp9",
"5cs1",
"5cs3"... | 59 | [
"PUB00000342",
"PUB00005679",
"PUB00017940",
"PUB00017941",
"PUB00017942",
"PUB00017943",
"PUB00017944"
] | [
"1998666",
"10561497",
"1998667",
"8662705",
"9632702",
"11376658",
"9493272"
] | [
"Location of the disulfide bonds in human plasma prekallikrein: the presence of four novel apple domains in the amino-terminal portion of the molecule.",
"The PAN module: the N-terminal domains of plasminogen and hepatocyte growth factor are homologous with the apple domains of the prekallikrein family and with a... | [
1991,
1999,
1991,
1996,
1998,
2001,
1998
] | 7 | [] | [
"IPR000177"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Nucleocytoviricota",
"metagenomes"
] | [
4,
1548,
75122,
115,
81
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
250,
45,
16,
20,
42,
12,
5,
304,
27,
241
] | 10 | true | Domain | PAN/Apple domain | PAN/Apple domain | Pan_app | 7 |
IPR003610 | 3,610 | Carbohydrate binding module family 5/12 | CBM5/12 | Domain | 19,086 | false | false | This entry represents and . These modules have a core structure consisting of a 3-stranded meander β-sheet, which contain six aromatic groups that may be important for binding. CBM5/12 is found in proteins such as chitinase A1, chitinase B [ ], and endoglucanase Z [ ]. The overall topology of the CBM is structurally si... | [
"GO:0004553",
"GO:0030246",
"GO:0005975",
"GO:0005576"
] | [
"hydrolase activity, hydrolyzing O-glycosyl compounds",
"carbohydrate binding",
"carbohydrate metabolic process",
"extracellular region"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"PFAM",
"SMART"
] | [
"PF02839",
"SM00495"
] | [
"CBM_5_12",
"ChtBD3"
] | [
14411,
18019
] | 2 | [
"EC",
"GP"
] | [
"3.2.1",
"GenProp1522"
] | [
"EC:3.2.1",
"GP:GenProp1522"
] | 2 | [
"1aiw",
"1e15",
"1e6n",
"1e6p",
"1e6r",
"1e6z",
"1ed7",
"1goi",
"1gpf",
"1h0g",
"1h0i",
"1o6i",
"1ogb",
"1ogg",
"1ur8",
"1ur9",
"1w1p",
"1w1t",
"1w1v",
"1w1y",
"1wvu",
"1wvv",
"2d49",
"2dbt",
"2rts",
"3wd0",
"3wd1",
"3wd2",
"3wd3",
"3wd4",
"3wx7",
"4hmc"... | 76 | [
"PUB00014167",
"PUB00014168",
"PUB00054922",
"PUB00054923",
"PUB00054924"
] | [
"9405041",
"10788483",
"3338453",
"3134347",
"15214846"
] | [
"Solution structure of the cellulose-binding domain of the endoglucanase Z secreted by Erwinia chrysanthemi.",
"Solution structure of the chitin-binding domain of Bacillus circulans WL-12 chitinase A1.",
"Studies of the cellulolytic system of Trichoderma reesei QM 9414. Analysis of domain function in two cellob... | [
1997,
2000,
1988,
1988,
2004
] | 5 | [] | [
"IPR032798"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"Viruses",
"metagenomes"
] | [
17130,
1545,
228,
133,
50
] | 5 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Domain | Carbohydrate binding module family 5/12 | Carbohydrate binding module family 5/12 | CBM5/12 | 4 |
IPR003611 | 3,611 | Nuclease associated modular domain 3 | NUMOD3 | Domain | 4,096 | false | false | NUMOD3 (nuclease associated modular domain 3) is a DNA-binding motif found in homing endonucleases and related proteins. It occurs on its own or in tandem repeats in GIY-YIG and HTH proteins. It constitutes a β-turn-loop-helix subregion of the the DNA-binding domain of I-TevI homing endonuclease ( ) [ ]. | [
"GO:0003677"
] | [
"DNA binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"SMART"
] | [
"PF07460",
"SM00496"
] | [
"NUMOD3",
"IENR2"
] | [
3705,
2152
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00013165"
] | [
"13678957"
] | [
"New types of conserved sequence domains in DNA-binding regions of homing endonucleases."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
31,
407,
2491,
771,
396
] | 5 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
16,
2,
4,
7
] | 4 | true | Domain | Nuclease associated modular domain 3 | Nuclease associated modular domain 3 | NUMOD3 | 8 |
IPR003613 | 3,613 | U-box domain | Ubox_domain | Domain | 67,720 | false | false | This entry represents the U-box domain. The molecular mechanism underlying the transfer of ubiquitin (Ub) to a substrate consists of three key enzymatic steps. First, ubiquitin itself is adenylated at its C-terminal glycine residue by an activating enzyme (E1). Second, the adenylated Ub forms a covalent linkage to a co... | [
"GO:0004842",
"GO:0016567"
] | [
"ubiquitin-protein transferase activity",
"protein ubiquitination"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF04564",
"PS51698",
"SM00504"
] | [
"U-box",
"U_BOX",
"Ubox"
] | [
56230,
60413,
63561
] | 3 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"... | [
"2.3.2.27",
"PWY-7511",
"R-BTA-6781823",
"R-BTA-6782135",
"R-BTA-6782210",
"R-BTA-72163",
"R-BTA-983168",
"R-CEL-210991",
"R-CEL-6781823",
"R-CEL-6782135",
"R-CEL-6782210",
"R-CEL-72163",
"R-DDI-6781823",
"R-DDI-6782135",
"R-DDI-6782210",
"R-DDI-72163",
"R-GGA-2173788",
"R-GGA-5357... | [
"EC:2.3.2.27",
"METACYC:PWY-7511",
"REACTOME:R-BTA-6781823",
"REACTOME:R-BTA-6782135",
"REACTOME:R-BTA-6782210",
"REACTOME:R-BTA-72163",
"REACTOME:R-BTA-983168",
"REACTOME:R-CEL-210991",
"REACTOME:R-CEL-6781823",
"REACTOME:R-CEL-6782135",
"REACTOME:R-CEL-6782210",
"REACTOME:R-CEL-72163",
"RE... | 75 | [
"1n87",
"1t1h",
"1wgm",
"2bay",
"2c2l",
"2c2v",
"2f42",
"2kr4",
"2kre",
"2oxq",
"2qiz",
"2qj0",
"3jb9",
"3l1x",
"3l1z",
"3m62",
"3m63",
"3ztg",
"4wz0",
"4wz2",
"4wz3",
"4xi1",
"5gm6",
"5gmk",
"5lj5",
"5m88",
"5mq0",
"5mqf",
"5o75",
"5olm",
"5wsg",
"5xjc"... | 91 | [
"PUB00054319",
"PUB00072581",
"PUB00072582"
] | [
"20017557",
"11435423",
"18393940"
] | [
"Structural and functional characterization of the monomeric U-box domain from E4B.",
"U box proteins as a new family of ubiquitin-protein ligases.",
"Biochemical function of typical and variant Arabidopsis thaliana U-box E3 ubiquitin-protein ligases."
] | [
2010,
2001,
2008
] | 3 | [] | [
"IPR026951",
"IPR039925",
"IPR045202",
"IPR045210",
"IPR055340"
] | 0 | 5 | 0 | [
"Acidianus sulfidivorans JP7",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
1,
167,
67394,
87,
71
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
283,
5,
55,
13,
33,
29,
5,
226,
57,
2,
3,
310
] | 12 | true | Domain | U-box domain | U-box domain | Ubox_domain | 1 |
IPR003615 | 3,615 | HNH nuclease | HNH_nuc | Domain | 122,617 | false | false | This domain is found in HNH family of nucleases that includes yeast intron 1 protein, human DNA annealing helicase and endonuclease ZRANB3, bacterial CRISPR-associated endonuclease Cas9, colicins, pyocins and endonuclease HphI. Members in this group are found in all domains of life. | [] | [] | [] | 0 | [
"PFAM",
"PFAM",
"PFAM",
"SMART",
"CDD"
] | [
"PF13391",
"PF13392",
"PF13395",
"SM00507",
"cd00085"
] | [
"HNH_2",
"HNH_3",
"HNH_4",
"HNHc",
"HNHc"
] | [
17423,
13817,
4066,
68497,
89599
] | 5 | [] | [] | [] | 0 | [
"1m08",
"1mz8",
"1pt3",
"1u3e",
"2jb0",
"3fbd",
"3u43",
"3zfk",
"4cmp",
"4cmq",
"4h9d",
"4ogc",
"4oge",
"4oo8",
"4qko",
"4uhp",
"4uhq",
"4un3",
"4un4",
"4un5",
"4zt0",
"4zt9",
"5axw",
"5b2r",
"5b2s",
"5b2t",
"5czz",
"5f9r",
"5fq5",
"5fw1",
"5fw2",
"5fw3"... | 255 | [] | [] | [] | [] | 0 | [] | [
"IPR002711",
"IPR029471"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1492,
94107,
14832,
8703,
3483
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)... | [
22,
3,
4,
3,
2,
2,
13,
6,
2,
1,
18
] | 11 | true | Domain | HNH nuclease | HNH nuclease | HNH_nuc | 9 |
IPR003616 | 3,616 | Post-SET domain | Post-SET_dom | Domain | 45,882 | false | false | This region is found in a number of histone lysine methyltransferases (HMTase), C-terminal to the SET domain; it is generally described as the post-SET domain. Histone lysine methylation is part of the histone code that regulated chromatin function and epigenetic control of gene function. Histone lysine methyltransfera... | [] | [] | [] | 0 | [
"PROFILE",
"SMART"
] | [
"PS50868",
"SM00508"
] | [
"POST_SET",
"PostSET"
] | [
45833,
25910
] | 2 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.1.1",
"PDOC50280",
"R-CEL-3214841",
"R-CEL-8936459",
"R-CEL-9772755",
"R-DDI-3214841",
"R-DDI-9772755",
"R-DME-201722",
"R-DME-3214841",
"R-DME-427359",
"R-DME-8936459",
"R-DME-8939236",
"R-DME-9772755",
"R-DME-9843940",
"R-DRE-3214841",
"R-DRE-9843940",
"R-DRE-9843970",
"R-HSA-... | [
"EC:2.1.1",
"PROSITEDOC:PDOC50280",
"REACTOME:R-CEL-3214841",
"REACTOME:R-CEL-8936459",
"REACTOME:R-CEL-9772755",
"REACTOME:R-DDI-3214841",
"REACTOME:R-DDI-9772755",
"REACTOME:R-DME-201722",
"REACTOME:R-DME-3214841",
"REACTOME:R-DME-427359",
"REACTOME:R-DME-8936459",
"REACTOME:R-DME-8939236",
... | 57 | [
"1ml9",
"1mvh",
"1mvx",
"1peg",
"2r3a",
"2w5y",
"2w5z",
"3bo5",
"3ooi",
"3ope",
"4fmu",
"4h12",
"4qen",
"4qeo",
"4qep",
"4ynm",
"4ynp",
"4ypa",
"4ype",
"4ypu",
"4z4p",
"5f59",
"5f5e",
"5f6k",
"5f6l",
"5jjy",
"5jlb",
"5jle",
"5lss",
"5lsu",
"5lsx",
"5lsy"... | 118 | [
"PUB00015425",
"PUB00018235",
"PUB00029363",
"PUB00029821",
"PUB00033352",
"PUB00033353"
] | [
"11691919",
"12372305",
"12540855",
"12887903",
"12123582",
"11893494"
] | [
"The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes.",
"Structure of the Neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase.",
"Structure and catalytic mechanism of the human histone... | [
2001,
2002,
2003,
2003,
2002,
2002
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
10,
2756,
43044,
6,
66
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
88,
8,
145,
14,
65,
51,
5,
61,
60,
2,
3,
152
] | 12 | true | Domain | Post-SET domain | Post-SET domain | Post-SET_dom | 7 |
IPR003617 | 3,617 | Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type | TFIIS/CRSP70_N_sub | Domain | 15,966 | false | false | Transcription factor S-II (TFIIS) induces mRNA cleavage by enhancing the intrinsic nuclease activity of RNA polymerase (Pol) II, past template-encoded pause sites. It is widely distributed being found in mammals, Drosophila, yeast and in the archaebacteria Sulfolobus acidocaldarius [ ]. S-II proteins have a relatively ... | [
"GO:0005634"
] | [
"nucleus"
] | [
"cellular_component"
] | 1 | [
"SMART"
] | [
"SM00509"
] | [
"TFS2N"
] | [
15966
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-674695",
"R-BTA-6781823",
"R-BTA-6782135",
"R-BTA-6782210",
"R-BTA-6796648",
"R-BTA-75955",
"R-CEL-112382",
"R-CEL-674695",
"R-CEL-6781823",
"R-CEL-6782135",
"R-CEL-6782210",
"R-CEL-6796648",
"R-CEL-75955",
"R-DDI-6781823",
"R-DDI-6782135",
"R-DDI-6782210",
"R-DDI-6796648",
... | [
"REACTOME:R-BTA-674695",
"REACTOME:R-BTA-6781823",
"REACTOME:R-BTA-6782135",
"REACTOME:R-BTA-6782210",
"REACTOME:R-BTA-6796648",
"REACTOME:R-BTA-75955",
"REACTOME:R-CEL-112382",
"REACTOME:R-CEL-674695",
"REACTOME:R-CEL-6781823",
"REACTOME:R-CEL-6782135",
"REACTOME:R-CEL-6782210",
"REACTOME:R-C... | 65 | [
"1eo0",
"1pqv",
"1wjt",
"5iy6",
"5iy7",
"5iy8",
"5iya",
"5iyb",
"5iyc",
"5odd",
"6o9l",
"6vti",
"6zuy",
"6zuz",
"6zv2",
"6zv3",
"6zv4",
"7cnf",
"7emf",
"7ena",
"7enc",
"7enj",
"7faw",
"7lqt",
"7ui9",
"7uif",
"7uio",
"7unc",
"7und",
"8a40",
"8gxq",
"8gxs"... | 51 | [
"PUB00004419",
"PUB00006267",
"PUB00006554",
"PUB00011910"
] | [
"8502569",
"1917889",
"8566795",
"12914699"
] | [
"Putative tfIIs gene of Sulfolobus acidocaldarius encoding an archaeal transcription elongation factor is situated directly downstream of the gene for a small subunit of DNA-dependent RNA polymerase.",
"Heterogeneity and tissue-specific expression of eukaryotic transcription factor S-II-related protein mRNA.",
... | [
1993,
1991,
1995,
2003
] | 4 | [
"IPR017923"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
15966
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
75,
1,
68,
5,
29,
19,
1,
41,
27,
1,
1,
74
] | 12 | true | Domain | Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type | Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type | TFIIS/CRSP70_N_sub | 8 |
IPR003618 | 3,618 | Transcription elongation factor S-II, central domain | TFIIS_cen_dom | Domain | 17,595 | false | false | This domain is found in the central region of transcription elongation factor S-II and in several hypothetical proteins. Transcription factor S-II (TFIIS) induces mRNA cleavage by enhancing the intrinsic nuclease activity of RNA polymerase (Pol) II, past template-encoded pause sites. It is widely distributed being foun... | [
"GO:0006351"
] | [
"DNA-templated transcription"
] | [
"biological_process"
] | 1 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF07500",
"PS51321",
"SM00510"
] | [
"TFIIS_M",
"TFIIS_CENTRAL",
"TFS2M"
] | [
16701,
17265,
15211
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-674695",
"R-BTA-6781823",
"R-BTA-6782135",
"R-BTA-6782210",
"R-BTA-6796648",
"R-BTA-75955",
"R-CEL-112382",
"R-CEL-674695",
"R-CEL-6781823",
"R-CEL-6782135",
"R-CEL-6782210",
"R-CEL-6796648",
"R-CEL-75955",
"R-DDI-6781823",
"R-DDI-6782135",
"R-DDI-6782210",
"R-DDI-6796648",
... | [
"REACTOME:R-BTA-674695",
"REACTOME:R-BTA-6781823",
"REACTOME:R-BTA-6782135",
"REACTOME:R-BTA-6782210",
"REACTOME:R-BTA-6796648",
"REACTOME:R-BTA-75955",
"REACTOME:R-CEL-112382",
"REACTOME:R-CEL-674695",
"REACTOME:R-CEL-6781823",
"REACTOME:R-CEL-6782135",
"REACTOME:R-CEL-6782210",
"REACTOME:R-C... | 63 | [
"1enw",
"1pqv",
"1y1v",
"1y1y",
"2dme",
"2lw4",
"3gtm",
"3ndq",
"3po3",
"4bxx",
"4bxz",
"4by1",
"4by7",
"5fmf",
"5iy6",
"5iy7",
"5iy8",
"5iya",
"5iyb",
"5iyc",
"5xon",
"6o9l",
"7ui9",
"7uif",
"7uio",
"7unc",
"7und",
"8a40",
"8uis",
"8umh",
"8umi",
"8uoq"... | 42 | [
"PUB00004419",
"PUB00006267",
"PUB00006554",
"PUB00011910"
] | [
"8502569",
"1917889",
"8566795",
"12914699"
] | [
"Putative tfIIs gene of Sulfolobus acidocaldarius encoding an archaeal transcription elongation factor is situated directly downstream of the gene for a small subunit of DNA-dependent RNA polymerase.",
"Heterogeneity and tissue-specific expression of eukaryotic transcription factor S-II-related protein mRNA.",
... | [
1993,
1991,
1995,
2003
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Nucleocytoviricota",
"metagenomes"
] | [
5,
21,
17396,
54,
119
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
58,
1,
65,
6,
27,
23,
2,
14,
27,
2,
2,
31
] | 12 | true | Domain | Transcription elongation factor S-II, central domain | Transcription elongation factor S-II, central domain | TFIIS_cen_dom | 9 |
IPR003619 | 3,619 | MAD homology 1, Dwarfin-type | MAD_homology1_Dwarfin-type | Domain | 24,033 | false | false | Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth [ ]. The dwarfin family also includes the Drosophila protein MAD that is required for the function of decapentaplegic (DPP) and may play a role in DPP signalling. Drosophila Mad binds to DNA... | [
"GO:0006355"
] | [
"regulation of DNA-templated transcription"
] | [
"biological_process"
] | 1 | [
"PFAM",
"SMART"
] | [
"PF03165",
"SM00523"
] | [
"MH1",
"DWA"
] | [
23924,
23816
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-201451",
"R-BTA-5689880",
"R-BTA-8941326",
"R-CEL-1181150",
"R-CEL-1502540",
"R-CEL-201451",
"R-CEL-2173788",
"R-CEL-2173789",
"R-CEL-2173795",
"R-CEL-2173796",
"R-CEL-5689880",
"R-CEL-8941326",
"R-CEL-8941855",
"R-CEL-9617828",
"R-DME-1181150",
"R-DME-1502540",
"R-DME-201451"... | [
"REACTOME:R-BTA-201451",
"REACTOME:R-BTA-5689880",
"REACTOME:R-BTA-8941326",
"REACTOME:R-CEL-1181150",
"REACTOME:R-CEL-1502540",
"REACTOME:R-CEL-201451",
"REACTOME:R-CEL-2173788",
"REACTOME:R-CEL-2173789",
"REACTOME:R-CEL-2173795",
"REACTOME:R-CEL-2173796",
"REACTOME:R-CEL-5689880",
"REACTOME:... | 100 | [
"1mhd",
"1ozj",
"3kmp",
"3qsv",
"5mey",
"5mez",
"5mf0",
"5nm9",
"5od6",
"5odg",
"5x6g",
"5x6h",
"5x6m",
"6fzs",
"6fzt",
"6h3r",
"6tbz",
"6tce",
"6zmn",
"7qqd",
"7qqe",
"9qky"
] | 22 | [
"PUB00004255",
"PUB00004902",
"PUB00019858"
] | [
"9230443",
"8799132",
"11532220"
] | [
"Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic.",
"Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth.",
"The Smads."
] | [
1997,
1996,
2001
] | 3 | [] | [
"IPR013019"
] | 0 | 1 | 0 | [
"Metazoa",
"bird metagenome"
] | [
24030,
3
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
175,
12,
111,
58,
82
] | 6 | true | Domain | MAD homology 1, Dwarfin-type | MAD homology 1, Dwarfin-type | MAD_homology1_Dwarfin-type | 6 |
IPR003620 | 3,620 | Urocortin/corticotropin-releasing factor | Urocortin_CRF | Family | 1,602 | false | false | Corticotropin-releasing factor (CRF), urotensin-I, urocortin and sauvagine form a family of related neuropeptides in vertebrates. The family can be grouped into 2 separate paralogous lineages, with urotensin-I, urocortin and sauvagine in one group and CRF forming the other group. Urocortin and sauvagine appear to repre... | [
"GO:0005179",
"GO:0005576"
] | [
"hormone activity",
"extracellular region"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS",
"PANTHER"
] | [
"PR01612",
"PTHR15035"
] | [
"CRFFAMILY",
""
] | [
1583,
1593
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-373080",
"R-BTA-418555",
"R-HSA-373080",
"R-HSA-418555",
"R-HSA-422085",
"R-HSA-9022702",
"R-MMU-373080",
"R-MMU-418555",
"R-RNO-373080",
"R-SSC-373080",
"R-SSC-418555"
] | [
"REACTOME:R-BTA-373080",
"REACTOME:R-BTA-418555",
"REACTOME:R-HSA-373080",
"REACTOME:R-HSA-418555",
"REACTOME:R-HSA-422085",
"REACTOME:R-HSA-9022702",
"REACTOME:R-MMU-373080",
"REACTOME:R-MMU-418555",
"REACTOME:R-RNO-373080",
"REACTOME:R-SSC-373080",
"REACTOME:R-SSC-418555"
] | 11 | [
"1go9",
"1goe",
"2jnd",
"2l27",
"2rmd",
"2rme",
"2rmf",
"2rmi",
"6p9x",
"6pb0",
"6pb1",
"7try",
"7ts0"
] | 13 | [
"PUB00004937",
"PUB00007067",
"PUB00155077"
] | [
"2200028",
"10375459",
"7309372"
] | [
"Evolutionary aspects of corticotropin releasing hormones.",
"Evolution and physiology of the corticotropin-releasing factor (CRF) family of neuropeptides in vertebrates.",
"Amino acid composition and sequence analysis of sauvagine, a new active peptide from the skin of Phyllomedusa sauvagei."
] | [
1990,
1999,
1981
] | 3 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
1602
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
2,
4
] | 4 | true | Family | Urocortin/corticotropin-releasing factor | Urocortin/corticotropin-releasing factor | Urocortin_CRF | 1 |
IPR003624 | 3,624 | Leukemia inhibitory factor | Leukemia_IF | Family | 639 | false | false | Leukemia inhibitory factor is a small cytokine that has the capacity to induce terminal differentiation in leukemic cells. It also induces hematopoietic differentiation in normal and myeloid leukemia cells, and neuronal cell differentiation, as well as stimulating acute-phase protein synthesis in hepatocytes. | [
"GO:0005146",
"GO:0005576"
] | [
"leukemia inhibitory factor receptor binding",
"extracellular region"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS",
"PANTHER"
] | [
"PR01883",
"PTHR10633"
] | [
"LEUKAEMIAIF",
""
] | [
625,
633
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-6788467",
"R-HSA-6783783",
"R-HSA-6785807",
"R-HSA-6788467",
"R-MMU-6788467",
"R-RNO-6788467"
] | [
"REACTOME:R-BTA-6788467",
"REACTOME:R-HSA-6783783",
"REACTOME:R-HSA-6785807",
"REACTOME:R-HSA-6788467",
"REACTOME:R-MMU-6788467",
"REACTOME:R-RNO-6788467"
] | 6 | [
"1a7m",
"1emr",
"1lki",
"1pvh",
"2q7n",
"7n0a",
"8d6a"
] | 7 | [] | [] | [] | [] | 0 | [
"IPR001581"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
639
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
4
] | 3 | true | Family | Leukemia inhibitory factor | Leukemia inhibitory factor | Leukemia_IF | 9 |
IPR003625 | 3,625 | Parathyroid hormone | PTH | Family | 840 | false | false | Parathyroid hormone (PTH) is a polypeptidic hormone that elevates calcium level by dissolving the salts in bone and preventing their renal excretion. It stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells [ ]. Defects in PTH are a cause of familial isolated hypoparathyroidi... | [
"GO:0005179",
"GO:0006874",
"GO:0005576"
] | [
"hormone activity",
"intracellular calcium ion homeostasis",
"extracellular region"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PIRSF",
"PANTHER"
] | [
"PIRSF001832",
"PTHR10541"
] | [
"PTH",
""
] | [
579,
840
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-373080",
"R-BTA-418555",
"R-CFA-373080",
"R-GGA-373080",
"R-GGA-418555",
"R-HSA-373080",
"R-HSA-418555",
"R-MMU-373080",
"R-MMU-418555",
"R-RNO-373080",
"R-SSC-373080",
"R-SSC-418555"
] | [
"REACTOME:R-BTA-373080",
"REACTOME:R-BTA-418555",
"REACTOME:R-CFA-373080",
"REACTOME:R-GGA-373080",
"REACTOME:R-GGA-418555",
"REACTOME:R-HSA-373080",
"REACTOME:R-HSA-418555",
"REACTOME:R-MMU-373080",
"REACTOME:R-MMU-418555",
"REACTOME:R-RNO-373080",
"REACTOME:R-SSC-373080",
"REACTOME:R-SSC-418... | 12 | [
"1bwx",
"1et1",
"1fvy",
"1hph",
"1hpy",
"1hth",
"1zwa",
"1zwb",
"1zwc",
"1zwd",
"1zwe",
"1zwf",
"1zwg",
"2l1x",
"7vvk",
"7vvl",
"7vvm",
"7vvn",
"7vvo",
"7y36",
"8flq",
"8ha0",
"8hao",
"8t5f",
"9jr2",
"9jr3"
] | 26 | [
"PUB00073586",
"PUB00073587"
] | [
"21076856",
"10523031"
] | [
"Stimulation of glucose transport in osteoblastic cells by parathyroid hormone and insulin-like growth factor I.",
"A novel mutation of the signal peptide of the preproparathyroid hormone gene associated with autosomal recessive familial isolated hypoparathyroidism."
] | [
2011,
1999
] | 2 | [
"IPR001415"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
840
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
1,
3
] | 4 | true | Family | Parathyroid hormone | Parathyroid hormone | PTH | 8 |
IPR003626 | 3,626 | Parathyroid hormone-related protein | PTH-rel | Family | 1,565 | false | false | Parathyroid hormone-related protein (PTH-rP) is structurally related to parathyroid hormone (PTH) [ ] and seems to play a physiological role in lactation, possibly as a hormone for the mobilisation and/or transfer of calcium to the milk. It also regulates chondrocytic differentiation and bone formation [ ]. This family... | [
"GO:0005179",
"GO:0030282",
"GO:0005576"
] | [
"hormone activity",
"bone mineralization",
"extracellular region"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PANTHER"
] | [
"PTHR17223"
] | [
""
] | [
1565
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-373080",
"R-BTA-418555",
"R-CFA-373080",
"R-GGA-373080",
"R-GGA-418555",
"R-HSA-373080",
"R-HSA-418555",
"R-MMU-373080",
"R-MMU-418555",
"R-RNO-373080"
] | [
"REACTOME:R-BTA-373080",
"REACTOME:R-BTA-418555",
"REACTOME:R-CFA-373080",
"REACTOME:R-GGA-373080",
"REACTOME:R-GGA-418555",
"REACTOME:R-HSA-373080",
"REACTOME:R-HSA-418555",
"REACTOME:R-MMU-373080",
"REACTOME:R-MMU-418555",
"REACTOME:R-RNO-373080"
] | 10 | [
"1bzg",
"3ffd",
"6nbf",
"6nbh",
"6nbi",
"7vvj",
"7y35",
"8flr",
"8fls",
"8flu",
"8haf",
"9b5y",
"9lxr"
] | 13 | [
"PUB00005076",
"PUB00056855",
"PUB00088185"
] | [
"2682846",
"11760831",
"28148780"
] | [
"Parathyroid hormone-related protein: isolation, molecular cloning, and mechanism of action.",
"Parathyroid hormone-related protein is required for normal intramembranous bone development.",
"Pth4, an ancient parathyroid hormone lost in eutherian mammals, reveals a new brain-to-bone signaling pathway."
] | [
1989,
2001,
2017
] | 3 | [
"IPR001415"
] | [] | 1 | 0 | 1 | [
"Vertebrata"
] | [
1565
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
4,
4,
3
] | 4 | true | Family | Parathyroid hormone-related protein | Parathyroid hormone-related protein | PTH-rel | 9 |
IPR003635 | 3,635 | Neurokinin-B/Tachykinin-3 | Neurokinin-B/TAC3 | Family | 625 | false | false | Tachykinins [ , , ] are a group of biologically active peptides which excite neurons, evoke behavioral responses, are potent vasodilatators and contract (directly or indirectly) many smooth muscles. This family includes neurokinin B (also known as Tachykinin-3), as well as many other peptides. Like other tachykinins, n... | [
"GO:0007217"
] | [
"tachykinin receptor signaling pathway"
] | [
"biological_process"
] | 1 | [
"PFAM",
"PIRSF",
"PRINTS",
"PANTHER"
] | [
"PF03823",
"PIRSF001843",
"PR01828",
"PTHR15536"
] | [
"Neurokinin_B",
"Neurokinin",
"NEUROKININB",
""
] | [
322,
105,
332,
608
] | 4 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-380095",
"R-BTA-416476",
"R-HSA-380095",
"R-HSA-416476",
"R-MMU-380095",
"R-MMU-416476",
"R-RNO-380095",
"R-RNO-416476",
"R-SSC-380095",
"R-SSC-416476"
] | [
"REACTOME:R-BTA-380095",
"REACTOME:R-BTA-416476",
"REACTOME:R-HSA-380095",
"REACTOME:R-HSA-416476",
"REACTOME:R-MMU-380095",
"REACTOME:R-MMU-416476",
"REACTOME:R-RNO-380095",
"REACTOME:R-RNO-416476",
"REACTOME:R-SSC-380095",
"REACTOME:R-SSC-416476"
] | 10 | [] | 0 | [
"PUB00000127",
"PUB00001502",
"PUB00003623",
"PUB00068040"
] | [
"3284438",
"1969374",
"1324401",
"19079066"
] | [
"Tachykinins.",
"Diversity in mammalian tachykinin peptidergic neurons: multiple peptides, receptors, and regulatory mechanisms.",
"[Tachykinins and conformational aspects of their interactions with receptors]",
"TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokin... | [
1988,
1990,
1992,
2009
] | 4 | [] | [] | 0 | 0 | null | [
"Bilateria",
"Victivallis lenta"
] | [
624,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
1,
4
] | 4 | true | Family | Neurokinin-B/Tachykinin-3 | Neurokinin-B/Tachykinin-3 | Neurokinin-B/TAC3 | 1 |
IPR003645 | 3,645 | Follistatin-like, N-terminal | Fol_N | Domain | 15,068 | false | false | This EGF-like domain resembles the follistatin-N-terminal domain, and is distinct from the kazal-like sequence. Follistatin binds to activin and is a specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone [ , ]. This domain is also found in SPARC, a protein involved in the regula... | [] | [] | [] | 0 | [
"SMART"
] | [
"SM00274"
] | [
"FOLN"
] | [
15068
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-114608",
"R-BTA-201451",
"R-BTA-2473224",
"R-BTA-3000178",
"R-BTA-3000497",
"R-BTA-381426",
"R-BTA-8957275",
"R-CEL-114608",
"R-CEL-3000178",
"R-CEL-381426",
"R-CEL-8957275",
"R-DRE-2473224",
"R-HSA-114608",
"R-HSA-1251985",
"R-HSA-1971475",
"R-HSA-201451",
"R-HSA-2022928",
... | [
"REACTOME:R-BTA-114608",
"REACTOME:R-BTA-201451",
"REACTOME:R-BTA-2473224",
"REACTOME:R-BTA-3000178",
"REACTOME:R-BTA-3000497",
"REACTOME:R-BTA-381426",
"REACTOME:R-BTA-8957275",
"REACTOME:R-CEL-114608",
"REACTOME:R-CEL-3000178",
"REACTOME:R-CEL-381426",
"REACTOME:R-CEL-8957275",
"REACTOME:R-D... | 78 | [
"1bmo",
"1lr7",
"1lr8",
"1lr9",
"1nub",
"2arp",
"2b0u",
"2kcx",
"2p6a",
"2v53",
"3b4v",
"3hh2",
"3sek",
"5jhw",
"6jza",
"7kbu",
"8r0t",
"8rde",
"8s9p"
] | 19 | [
"PUB00039476",
"PUB00103969",
"PUB00103970",
"PUB00103971",
"PUB00103972"
] | [
"16198295",
"10402191",
"14563935",
"11716067",
"21885656"
] | [
"The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding.",
"Alternatively spliced isoforms of nerve- and muscle-derived agrin: their roles at the neuromuscular junction.",
"The role of follistatin domains in follistatin biological action.",
"SPARC modul... | [
2005,
1999,
2004,
2001,
2011
] | 5 | [] | [
"IPR015369"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota"
] | [
52,
15016
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
16,
98,
21,
34,
38,
52
] | 6 | true | Domain | Follistatin-like, N-terminal | Follistatin-like, N-terminal | Fol_N | 8 |
IPR003646 | 3,646 | SH3-like domain, bacterial-type | SH3-like_bac-type | Domain | 40,535 | false | false | SH3 domains are widespread among metazoan intracellular signalling proteins and typically bind proline-rich polypeptides. This SH3 domain is a prokaryotic homologue. It might have two possible functions: (1) promoting survival of a pathogen within the invaded cell by modulating pathways controlled by SH3 domains; or (2... | [] | [] | [] | 0 | [
"PFAM",
"PFAM",
"PROFILE",
"SMART"
] | [
"PF08239",
"PF08460",
"PS51781",
"SM00287"
] | [
"SH3_3",
"SH3_5",
"SH3B",
"SH3b"
] | [
33877,
1850,
25625,
25950
] | 4 | [] | [] | [] | 0 | [
"1r77",
"2kq8",
"2krs",
"2kt8",
"2kyb",
"2mk5",
"4krt",
"4lxc",
"5d74",
"5d76",
"5leo",
"5nmy",
"5o1q",
"5udm",
"5udn",
"6akv",
"6bim",
"6bio",
"6biq",
"6rje",
"6rk4",
"7aqh",
"7bng",
"7bnh",
"7bni",
"8h1i",
"8xyf",
"9kz1",
"9ovi"
] | 29 | [
"PUB00001025",
"PUB00001031",
"PUB00001644",
"PUB00004203",
"PUB00005506",
"PUB00007145",
"PUB00019876",
"PUB00084290"
] | [
"15335710",
"7953536",
"1639195",
"7531822",
"14731533",
"11256992",
"10369758",
"10322416"
] | [
"SH2 and SH3 domains.",
"SH3 domains. Molecular 'Velcro'.",
"SH3--an abundant protein domain in search of a function.",
"Protein modules and signalling networks.",
"Signalling through SH2 and SH3 domains.",
"SH3 domains: complexity in moderation.",
"Eukaryotic signalling domain homologues in archaea and... | [
1993,
1994,
1992,
1995,
1993,
2001,
1999,
1999
] | 8 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
14,
39143,
528,
461,
389
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)"
] | [
1,
1
] | 2 | true | Domain | SH3-like domain, bacterial-type | SH3-like domain, bacterial-type | SH3-like_bac-type | 7 |
IPR003647 | 3,647 | Intron encoded nuclease repeat | Intron_nuc_1_rpt | Repeat | 2,785 | false | false | This is a repeat of unknown function, but possibly involved in DNA-binding via a helix-turn-helix motif. | [] | [] | [] | 0 | [
"SMART"
] | [
"SM00497"
] | [
"IENR1"
] | [
2785
] | 1 | [] | [] | [] | 0 | [
"1u3e"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
533,
1385,
755,
112
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
2,
1
] | 2 | true | Repeat | Intron encoded nuclease repeat | Intron encoded nuclease repeat | Intron_nuc_1_rpt | 1 |
IPR003649 | 3,649 | B-box, C-terminal | Bbox_C | Domain | 23,177 | false | false | The B-box C-terminal domain is a coiled coil region C-terminal to (some) B-Box domains ( ). It is found in Tripartite motif-containing protein 2/3/67/66, E3 ubiquitin-protein ligase TRIM9/TRIM33/TRIM23/TRIM45/TRIM37, Fibronectin type III and similar proteins. | [] | [] | [] | 0 | [
"SMART"
] | [
"SM00502"
] | [
"BBC"
] | [
23177
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"... | [
"2.3.2.27",
"PWY-7511",
"R-BTA-983168",
"R-CEL-1660514",
"R-CEL-199992",
"R-CEL-432720",
"R-CEL-432722",
"R-CEL-6798695",
"R-CEL-6807878",
"R-CEL-6811434",
"R-DME-983168",
"R-HSA-1839117",
"R-HSA-212436",
"R-HSA-2173795",
"R-HSA-3899300",
"R-HSA-5655302",
"R-HSA-6802952",
"R-HSA-87... | [
"EC:2.3.2.27",
"METACYC:PWY-7511",
"REACTOME:R-BTA-983168",
"REACTOME:R-CEL-1660514",
"REACTOME:R-CEL-199992",
"REACTOME:R-CEL-432720",
"REACTOME:R-CEL-432722",
"REACTOME:R-CEL-6798695",
"REACTOME:R-CEL-6807878",
"REACTOME:R-CEL-6811434",
"REACTOME:R-DME-983168",
"REACTOME:R-HSA-1839117",
"R... | 29 | [
"6h3a",
"6qaj",
"6qu1",
"7z36",
"8amr"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
23176,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
13,
55,
19,
66,
48,
72
] | 6 | true | Domain | B-box, C-terminal | B-box, C-terminal | Bbox_C | 1 |
IPR003650 | 3,650 | Orange domain | Orange_dom | Domain | 15,484 | false | false | The Orange domain is a motif of ~35 amino acids present in eukaryotic DNA-binding transcription repressors, which regulate cell differentiation, embryonic patterning and other biological processes in both vertebrates and invertebrates. The Orange domain is located just C-terminal to a basic helix-loop-helix (bHLH) doma... | [
"GO:0003677",
"GO:0006355"
] | [
"DNA binding",
"regulation of DNA-templated transcription"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF07527",
"PS51054",
"SM00511"
] | [
"Hairy_orange",
"ORANGE",
"ORANGE"
] | [
13221,
15185,
11094
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC51054",
"R-DME-432408",
"R-HSA-1368108",
"R-HSA-210744",
"R-HSA-2122947",
"R-HSA-2197563",
"R-HSA-2644606",
"R-HSA-2894862",
"R-HSA-8940973",
"R-HSA-8941856",
"R-HSA-9013508",
"R-HSA-9013695",
"R-HSA-9733709",
"R-HSA-9762293",
"R-HSA-9824272",
"R-HSA-9931510"
] | [
"PROSITEDOC:PDOC51054",
"REACTOME:R-DME-432408",
"REACTOME:R-HSA-1368108",
"REACTOME:R-HSA-210744",
"REACTOME:R-HSA-2122947",
"REACTOME:R-HSA-2197563",
"REACTOME:R-HSA-2644606",
"REACTOME:R-HSA-2894862",
"REACTOME:R-HSA-8940973",
"REACTOME:R-HSA-8941856",
"REACTOME:R-HSA-9013508",
"REACTOME:R-... | 16 | [
"2db7",
"7c4o"
] | 2 | [
"PUB00014284",
"PUB00018508",
"PUB00018509",
"PUB00018510"
] | [
"8524259",
"1427040",
"11840327",
"11162494"
] | [
"Specificity for the hairy/enhancer of split basic helix-loop-helix (bHLH) proteins maps outside the bHLH domain and suggests two separable modes of transcriptional repression.",
"Seven genes of the Enhancer of split complex of Drosophila melanogaster encode helix-loop-helix proteins.",
"Vertebrate hairy and En... | [
1995,
1992,
2001,
2001
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"mine drainage metagenome"
] | [
94,
15389,
1
] | 3 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
55,
16,
32,
26,
40
] | 5 | true | Domain | Orange domain | Orange domain | Orange_dom | 1 |
IPR003651 | 3,651 | Endonuclease III-like, iron-sulphur cluster loop motif | Endonuclease3_FeS-loop_motif | Conserved_site | 38,584 | false | false | Endonuclease III ( ) is a DNA repair enzyme which removes a number of damaged pyrimidines from DNA via its glycosylase activity and also cleaves the phosphodiester backbone at apurinic / apyrimidinic sites via a beta-elimination mechanism [ , ]. The structurally related DNA glycosylase MutY recognises and excises the m... | [
"GO:0051539"
] | [
"4 iron, 4 sulfur cluster binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"SMART"
] | [
"PF10576",
"SM00525"
] | [
"EndIII_4Fe-2S",
"FES"
] | [
23586,
35352
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-110329",
"R-BTA-110357",
"R-HSA-110328",
"R-HSA-110329",
"R-HSA-110330",
"R-HSA-110331",
"R-HSA-110357",
"R-HSA-9608287",
"R-HSA-9608290",
"R-HSA-9630221",
"R-HSA-9630222",
"R-MMU-110329",
"R-MMU-110331",
"R-MMU-110357",
"R-RNO-110331",
"R-RNO-110357",
"R-SCE-110329",
"R-SPO... | [
"REACTOME:R-BTA-110329",
"REACTOME:R-BTA-110357",
"REACTOME:R-HSA-110328",
"REACTOME:R-HSA-110329",
"REACTOME:R-HSA-110330",
"REACTOME:R-HSA-110331",
"REACTOME:R-HSA-110357",
"REACTOME:R-HSA-9608287",
"REACTOME:R-HSA-9608290",
"REACTOME:R-HSA-9630221",
"REACTOME:R-HSA-9630222",
"REACTOME:R-MMU... | 18 | [
"1kea",
"1kg2",
"1kg3",
"1kg4",
"1kg5",
"1kg6",
"1kg7",
"1kqj",
"1mud",
"1mun",
"1muy",
"1orn",
"1orp",
"1p59",
"1rrq",
"1rrs",
"1vrl",
"1wef",
"1weg",
"1wei",
"2abk",
"3g0q",
"3n5n",
"4unf",
"4uob",
"4yoq",
"4yph",
"4ypr",
"5kn8",
"5kn9",
"6q0c",
"6u7t"... | 52 | [
"PUB00002202",
"PUB00005158",
"PUB00006161",
"PUB00007293",
"PUB00007294",
"PUB00007295",
"PUB00007296"
] | [
"1328155",
"1411536",
"7664751",
"7773744",
"9032058",
"9846876",
"10900127"
] | [
"The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine).",
"Atomic structure of the DNA repair [4Fe-4S] enzyme endonuclease III.",
"Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure.",
"DNA repair prot... | [
1992,
1992,
1995,
1995,
1997,
1998,
2000
] | 7 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
988,
30575,
6437,
1,
583
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
... | [
20,
3,
2,
2,
25,
7,
15,
9,
1,
1,
83
] | 11 | true | Conserved_site | Endonuclease III-like, iron-sulphur cluster loop motif | Endonuclease III-like, iron-sulphur cluster loop motif | Endonuclease3_FeS-loop_motif | 2 |
IPR003652 | 3,652 | Ataxin, AXH domain | Ataxin_AXH_dom | Domain | 4,337 | false | false | Spinocerebellar ataxia type 1 is late-onset neurodegenerative diseases caused by the expansion of a CAG triplet repeat in the SCA1 gene. This results in the lengthening of a polyglutamine tract in the gene product ataxin-1 producing a toxic gain of function that results in neuronal death. | [
"GO:0003723",
"GO:0005515"
] | [
"RNA binding",
"protein binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF08517",
"PS51148",
"SM00536"
] | [
"AXH",
"AXH",
"AXH"
] | [
4178,
4305,
4137
] | 3 | [] | [] | [] | 0 | [
"1oa8",
"1v06",
"2m41",
"3qve",
"4apt",
"4aqp",
"4j2j",
"4j2l"
] | 8 | [
"PUB00020948",
"PUB00028052"
] | [
"12965213",
"14583607"
] | [
"The AXH module: an independently folded domain common to ataxin-1 and HBP1.",
"The structure of the AXH domain of spinocerebellar ataxin-1."
] | [
2003,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
104,
4226,
7
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
13,
1,
7,
13,
11
] | 6 | true | Domain | Ataxin, AXH domain | Ataxin, AXH domain | Ataxin_AXH_dom | 1 |
IPR003653 | 3,653 | Ulp1 protease family, C-terminal catalytic domain | Peptidase_C48_C | Domain | 57,357 | false | false | This entry represents the C-terminal part of ubiquitin-like proteases that displays full proteolytic activity [ ]. Deubiquitinating enzymes (DUB) form a large family of cysteine protease that can deconjugate ubiquitin or ubiquitin-like proteins from ubiquitin-conjugated proteins. They can be classified in 3 families ac... | [
"GO:0008234",
"GO:0006508"
] | [
"cysteine-type peptidase activity",
"proteolysis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PROFILE"
] | [
"PF02902",
"PS50600"
] | [
"Peptidase_C48",
"ULP_PROTEASE"
] | [
54880,
46663
] | 2 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.4.22.-",
"PDOC50600",
"R-CEL-3065679",
"R-CEL-6791226",
"R-CEL-9035034",
"R-HSA-3065679",
"R-HSA-5689603",
"R-HSA-6791226",
"R-HSA-8951664",
"R-HSA-9035034",
"R-MMU-3065679",
"R-MMU-5689603",
"R-MMU-6791226",
"R-MMU-8951664",
"R-MMU-9035034",
"R-RNO-3065679",
"R-RNO-5689603",
"R... | [
"EC:3.4.22.-",
"PROSITEDOC:PDOC50600",
"REACTOME:R-CEL-3065679",
"REACTOME:R-CEL-6791226",
"REACTOME:R-CEL-9035034",
"REACTOME:R-HSA-3065679",
"REACTOME:R-HSA-5689603",
"REACTOME:R-HSA-6791226",
"REACTOME:R-HSA-8951664",
"REACTOME:R-HSA-9035034",
"REACTOME:R-MMU-3065679",
"REACTOME:R-MMU-56896... | 24 | [
"1euv",
"1tgz",
"1th0",
"1xt9",
"2bkq",
"2bkr",
"2ckg",
"2ckh",
"2g4d",
"2hkp",
"2hl8",
"2hl9",
"2io0",
"2io1",
"2io2",
"2io3",
"2iy0",
"2iy1",
"2iyc",
"2iyd",
"2oiv",
"2oix",
"2xph",
"2xre",
"3eay",
"3zo5",
"5aek",
"5b5q",
"5hag",
"5jp1",
"5jp3",
"5lnb"... | 55 | [
"PUB00007548",
"PUB00007549",
"PUB00007550",
"PUB00007551",
"PUB00011704",
"PUB00020025",
"PUB00030423",
"PUB00076953"
] | [
"10603300",
"8982460",
"10094048",
"10882122",
"11517925",
"9891971",
"14725770",
"7044372"
] | [
"Deubiquitinating enzymes: their diversity and emerging roles.",
"Ubiquitin-dependent protein degradation.",
"A new protease required for cell-cycle progression in yeast.",
"Ulp1-SUMO crystal structure and genetic analysis reveal conserved interactions and a regulatory element essential for cell growth in yea... | [
1999,
1996,
1999,
2000,
2001,
1998,
2004,
1982
] | 8 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
709,
56367,
78,
203
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
205,
7,
50,
30,
1,
28,
25,
4,
510,
38,
2,
4,
542
] | 13 | true | Domain | Ulp1 protease family, C-terminal catalytic domain | Ulp1 protease family, C-terminal catalytic domain | Peptidase_C48_C | 8 |
IPR003654 | 3,654 | OAR domain | OAR_dom | Domain | 17,700 | false | false | This 14 amino acid motif has been identified within the C-terminal region of several paired-like homeodomain (HD) containing proteins [ , ]. It was named OAR domain after the initials of otp, aristaless, and rax [ ]. Although it has been proposed that this domain could be important for transactivation and be involved i... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE"
] | [
"PF03826",
"PS50803"
] | [
"OAR",
"OAR"
] | [
16392,
17444
] | 2 | [
"PROSITEDOC",
"REACTOME",
"REACTOME"
] | [
"PDOC50803",
"R-HSA-8866906",
"R-HSA-9834899"
] | [
"PROSITEDOC:PDOC50803",
"REACTOME:R-HSA-8866906",
"REACTOME:R-HSA-9834899"
] | 3 | [] | 0 | [
"PUB00007552",
"PUB00007553",
"PUB00007554",
"PUB00007555",
"PUB00007556"
] | [
"8944018",
"9466998",
"9096350",
"9140395",
"9482887"
] | [
"Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome.",
"A new human homeobox gene OGI2X is a member of the most conserved homeobox gene family and is expressed during heart development in mouse.",
"rax, a novel paired-type homeobox gene, ... | [
1996,
1998,
1997,
1997,
1998
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"freshwater metagenome"
] | [
18,
17681,
1
] | 3 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
63,
17,
36,
30,
46
] | 5 | true | Domain | OAR domain | OAR domain | OAR_dom | 8 |
IPR003655 | 3,655 | Ancestral KRAB domain | aKRAB | Domain | 3,589 | false | false | This domain of about 70 amino acid residues is related to the Krueppel-associated box (KRAB) domain and has been recently stratified as the ancestral KRAB domain (aKRAB). Sequence analysis revealed that these sequences have a motif that can also be traced in invertebrates, whose homologues still exist in mammals, inclu... | [
"GO:0006355"
] | [
"regulation of DNA-templated transcription"
] | [
"biological_process"
] | 1 | [
"PROFILE"
] | [
"PS50806"
] | [
"KRAB_RELATED"
] | [
3589
] | 1 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC50806",
"R-HSA-212436",
"R-HSA-3214841",
"R-HSA-912446",
"R-HSA-9843940",
"R-MMU-3214841",
"R-RNO-3214841"
] | [
"PROSITEDOC:PDOC50806",
"REACTOME:R-HSA-212436",
"REACTOME:R-HSA-3214841",
"REACTOME:R-HSA-912446",
"REACTOME:R-HSA-9843940",
"REACTOME:R-MMU-3214841",
"REACTOME:R-RNO-3214841"
] | 7 | [] | 0 | [
"PUB00007557",
"PUB00007558",
"PUB00007559",
"PUB00007560",
"PUB00100497"
] | [
"7539744",
"8697803",
"9378559",
"9788446",
"35162997"
] | [
"Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma.",
"A novel Kruppel-associated box containing the SSX gene (SSX3) on the human X chromosome is not implicated in t(X;18)-positive synovial sarcomas.",
"SSX: a multigene family with... | [
1995,
1996,
1997,
1998,
2022
] | 5 | [
"IPR001909"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota"
] | [
10,
3579
] | 2 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
31,
45,
21
] | 3 | true | Domain | Ancestral KRAB domain | Ancestral KRAB domain | aKRAB | 3 |
IPR003656 | 3,656 | Zinc finger, BED-type | Znf_BED | Domain | 34,931 | false | false | The BED finger, which was named after the Drosophila proteins BEAF and DREF, is found in one or more copies in cellular regulatory factors and transposases from plants, animals and fungi. The BED finger is an about 50 to 60 amino acid residues domain that contains a characteristic motif with two highly conserved aromat... | [
"GO:0003677"
] | [
"DNA binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PFAM",
"PROFILE"
] | [
"PF02892",
"PF26664",
"PS50808"
] | [
"zf-BED",
"zf-BED_2",
"ZF_BED"
] | [
20336,
6319,
27793
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME"
] | [
"PDOC50808",
"R-CEL-4551638",
"R-HSA-4551638"
] | [
"PROSITEDOC:PDOC50808",
"REACTOME:R-CEL-4551638",
"REACTOME:R-HSA-4551638"
] | 3 | [
"2ct5",
"2djr",
"2elu",
"2elw",
"2rsi",
"2ruw",
"2rv4",
"2rv7",
"6j0d",
"7znf",
"8eb5",
"8edg",
"8sjd"
] | 13 | [
"PUB00007561",
"PUB00018276",
"PUB00018277"
] | [
"10973053",
"2152132",
"9225464"
] | [
"The BED finger, a novel DNA-binding domain in chromatin-boundary-element-binding proteins and transposases.",
"A metal-dependent DNA-binding protein interacts with a constitutive element of a light-responsive promoter.",
"Characterization of a DNA-binding protein that interacts with 5' flanking regions of two ... | [
2000,
1990,
1997
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
6,
2,
34893,
26,
4
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
71,
20,
25,
25,
10,
3,
1,
204,
2,
2,
227
] | 11 | true | Domain | Zinc finger, BED-type | Zinc finger, BED-type | Znf_BED | 2 |
IPR003657 | 3,657 | WRKY domain | WRKY_dom | Domain | 46,322 | false | false | The WRKY domain is a 60 amino acid region that is defined by the conserved amino acid sequence WRKYGQK at its N-terminal end, together with a novel zinc-finger-like motif. The WRKY domain is found in one or two copies in a superfamily of plant transcription factors involved in the regulation of various physiological pr... | [
"GO:0003700",
"GO:0043565",
"GO:0006355"
] | [
"DNA-binding transcription factor activity",
"sequence-specific DNA binding",
"regulation of DNA-templated transcription"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF03106",
"PS50811",
"SM00774"
] | [
"WRKY",
"WRKY",
"WRKY"
] | [
45622,
46025,
44410
] | 3 | [
"PROSITEDOC"
] | [
"PDOC50811"
] | [
"PROSITEDOC:PDOC50811"
] | 1 | [
"1wj2",
"2ayd",
"2lex",
"5w3x",
"6ir8",
"6j4e",
"6j4f",
"6j4g",
"7d11",
"7p8k",
"7z0r",
"7z0u",
"8iex",
"8k31"
] | 14 | [
"PUB00007562",
"PUB00033608"
] | [
"10785665",
"15705956"
] | [
"The WRKY superfamily of plant transcription factors.",
"Solution structure of an Arabidopsis WRKY DNA binding domain."
] | [
2000,
2005
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halobacteriales",
"Viruses"
] | [
36,
46244,
38,
4
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
367,
325,
425
] | 3 | true | Domain | WRKY domain | WRKY domain | WRKY_dom | 5 |
IPR003658 | 3,658 | Anti-sigma factor antagonist | Anti-sigma_ant | Family | 32,141 | false | false | An anti-sigma factor antagonist is an anti-anti-sigma factor, which relieves inhibition of sigma factor activity by the anti-sigma factor. Examples include the Bacillus subtilis SpoIIAA protein, which, in its phosphorylated form, acts as an anti-anti-sigma factor to relieve SpoIIAB inhibition of sigma F; and the anti-s... | [
"GO:0043856",
"GO:0006355"
] | [
"anti-sigma factor antagonist activity",
"regulation of DNA-templated transcription"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00377"
] | [
"ant_ant_sig"
] | [
32141
] | 1 | [] | [] | [] | 0 | [
"1auz",
"1buz",
"1h4x",
"1h4y",
"1h4z",
"1sbo",
"1t6r",
"1th8",
"1thn",
"1tid",
"1til",
"1vc1",
"2ka5",
"3f43",
"4hyl",
"4qtp",
"6m36",
"6m37",
"8ih8"
] | 19 | [] | [] | [] | [] | 0 | [] | [
"IPR014237"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Methanobacteriati",
"unclassified sequences"
] | [
31779,
17,
131,
214
] | 4 | [] | [] | 0 | true | Family | Anti-sigma factor antagonist | Anti-sigma factor antagonist | Anti-sigma_ant | 6 |
IPR003660 | 3,660 | HAMP domain | HAMP_dom | Domain | 483,363 | false | false | The HAMP domain (present in Histidine kinases, Adenyl cyclases, Methyl-accepting proteins and Phosphatases) is an approximately 50-amino acid α-helical region common to chemoreceptors and histidine kinases that is present in several multidomain sensor proteins that participate in a variety of signal transduction proces... | [
"GO:0007165",
"GO:0016020"
] | [
"signal transduction",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PFAM",
"PFAM",
"PROFILE",
"SMART"
] | [
"PF00672",
"PF18947",
"PF26769",
"PS50885",
"SM00304"
] | [
"HAMP",
"HAMP_2",
"HAMP_PhoQ",
"HAMP",
"HAMP"
] | [
366886,
11601,
25237,
472811,
383838
] | 5 | [
"EC",
"PROSITEDOC"
] | [
"2.7.13.3",
"PDOC50885"
] | [
"EC:2.7.13.3",
"PROSITEDOC:PDOC50885"
] | 2 | [
"2f95",
"2l7h",
"2l7i",
"2lfr",
"2lfs",
"2rm8",
"2y0q",
"2y0t",
"2y20",
"2y21",
"3vol",
"3zcc",
"3zrv",
"3zrw",
"3zrx",
"3zx6",
"4biu",
"4biv",
"4biw",
"4bix",
"4biy",
"4biz",
"4cb0",
"4cq4",
"4cti",
"4gn0",
"4gyc",
"5iji",
"5jef",
"5jeq",
"5jgp",
"5jje"... | 48 | [
"PUB00013561",
"PUB00053170",
"PUB00059704",
"PUB00075428",
"PUB00098067",
"PUB00100390",
"PUB00161094",
"PUB00161621",
"PUB00161622",
"PUB00161624",
"PUB00161994",
"PUB00161995",
"PUB00161996"
] | [
"10418137",
"10464230",
"16959572",
"11929534",
"24748383",
"20184894",
"26755627",
"15910283",
"2544889",
"9573193",
"14507375",
"22237544",
"11004187"
] | [
"The cytoplasmic helical linker domain of receptor histidine kinase and methyl-accepting proteins is common to many prokaryotic signalling proteins.",
"Molecular characterization of the PhoP-PhoQ two-component system in Escherichia coli K-12: identification of extracellular Mg2+-responsive promoters.",
"The HAM... | [
1999,
1999,
2006,
2002,
2014,
2010,
2016,
2005,
1989,
1998,
2003,
2012,
2000
] | 13 | [] | [
"IPR054693"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
3655,
472438,
7,
3553,
3710
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
3,
23,
1,
1
] | 4 | true | Domain | HAMP domain | HAMP domain | HAMP_dom | 3 |
IPR003661 | 3,661 | Signal transduction histidine kinase, dimerisation/phosphoacceptor domain | HisK_dim/P_dom | Domain | 710,654 | false | false | This entry represents the dimerisation and phosphoacceptor domain found in some histidine kinases. Signal transducing histidine kinases are the key elements in two-component signal transduction systems, which control complex processes such as the initiation of development in microorganisms [ ]. Examples of histidine ki... | [
"GO:0000155",
"GO:0007165"
] | [
"phosphorelay sensor kinase activity",
"signal transduction"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"SMART",
"CDD"
] | [
"PF00512",
"SM00388",
"cd00082"
] | [
"HisKA",
"HisKA",
"HisKA"
] | [
642972,
667454,
700422
] | 3 | [
"EC"
] | [
"2.7.13.3"
] | [
"EC:2.7.13.3"
] | 1 | [
"1joy",
"2c2a",
"2lfr",
"2lfs",
"3a0r",
"3d36",
"3dge",
"3jz3",
"3zcc",
"3zrv",
"3zrw",
"3zrx",
"4biu",
"4biv",
"4biw",
"4bix",
"4biy",
"4biz",
"4cb0",
"4cti",
"4gcz",
"4i5s",
"4jas",
"4jau",
"4jav",
"4kp4",
"4mt8",
"4mtx",
"4q20",
"4u7n",
"4u7o",
"4zki"... | 94 | [
"PUB00007866",
"PUB00013246",
"PUB00013247",
"PUB00020801"
] | [
"11406410",
"8868347",
"10426948",
"11145881"
] | [
"Histidine kinases and response regulator proteins in two-component signaling systems.",
"Protein aspartate phosphatases control the output of two-component signal transduction systems.",
"Solution structure of the homodimeric core domain of Escherichia coli histidine kinase EnvZ.",
"Bacteriophytochromes: new... | [
2001,
1996,
1999,
2000
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Plasmid Ti",
"Viruses",
"unclassified sequences"
] | [
9266,
658601,
36107,
1,
40,
6639
] | 6 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain ... | [
188,
20,
1,
1,
12,
55,
1,
3,
110
] | 9 | true | Domain | Signal transduction histidine kinase, dimerisation/phosphoacceptor domain | Signal transduction histidine kinase, dimerisation/phosphoacceptor domain | HisK_dim/P_dom | 3 |
IPR003663 | 3,663 | Sugar/inositol transporter | Sugar/inositol_transpt | Family | 173,293 | false | false | This family includes sugar transporters and the myo-inositol transporters. The sugar transporters belong to a superfamily of membrane proteins responsible for the binding and transport of various carbohydrates, organic alcohols, and acids in a wide range of prokaryotic and eukaryotic organisms [ ]. These integral membr... | [
"GO:0022857",
"GO:0055085",
"GO:0016020"
] | [
"transmembrane transporter activity",
"transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS",
"NCBIFAM"
] | [
"PR00171",
"TIGR00879"
] | [
"SUGRTRNSPORT",
"SP"
] | [
152573,
143356
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-189200",
"R-BTA-196836",
"R-BTA-422356",
"R-BTA-5653890",
"R-BTA-6798695",
"R-BTA-8981373",
"R-CEL-189200",
"R-CEL-196836",
"R-CEL-422356",
"R-CEL-429593",
"R-CEL-5653890",
"R-CEL-6798695",
"R-CEL-8981373",
"R-DME-189200",
"R-DME-196836",
"R-DME-422356",
"R-DME-5653890",
"R-... | [
"REACTOME:R-BTA-189200",
"REACTOME:R-BTA-196836",
"REACTOME:R-BTA-422356",
"REACTOME:R-BTA-5653890",
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-8981373",
"REACTOME:R-CEL-189200",
"REACTOME:R-CEL-196836",
"REACTOME:R-CEL-422356",
"REACTOME:R-CEL-429593",
"REACTOME:R-CEL-5653890",
"REACTOME:R-CEL... | 77 | [
"4gby",
"4gbz",
"4gc0",
"4ja3",
"4ja4",
"4lds",
"4pyp",
"4qiq",
"4yb9",
"4ybq",
"4zw9",
"4zwb",
"4zwc",
"5c65",
"5eqg",
"5eqh",
"5eqi",
"6h7d",
"6m20",
"6m2l",
"6n3i",
"6rw3",
"6tha",
"7aaq",
"7aar",
"7crz",
"7sps",
"7spt",
"7wsm",
"7wsn",
"8y65",
"8y66"... | 38 | [
"PUB00002464",
"PUB00003999",
"PUB00005096"
] | [
"3170580",
"3543693",
"3839598"
] | [
"Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues.",
"Mammalian and bacterial sugar transport proteins are homologous.",
"Sequence and structure of a human glucose transporter."
] | [
1988,
1987,
1985
] | 3 | [
"IPR005828"
] | [
"IPR044775",
"IPR045262",
"IPR045263",
"IPR047984"
] | 1 | 4 | 0 | [
"Aichi virus (strain Human/A846/88/1989)",
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1,
280,
18792,
154097,
123
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
255,
10,
51,
25,
3,
58,
33,
34,
185,
58,
31,
10,
306
] | 13 | true | Family | Sugar/inositol transporter | Sugar/inositol transporter | Sugar/inositol_transpt | 2 |
IPR003664 | 3,664 | Fatty acid synthesis PlsX protein | FA_synthesis | Family | 18,927 | false | false | The plsX gene is part of the bacterial fab gene cluster which encodes several key fatty acid biosynthetic enzymes [ ]. The plsX gene encodes a poorly understood enzyme of phospholipid metabolism [ ]. | [
"GO:0003824",
"GO:0016747",
"GO:0006633"
] | [
"catalytic activity",
"acyltransferase activity, transferring groups other than amino-acyl groups",
"fatty acid biosynthetic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM"
] | [
"PF02504"
] | [
"FA_synthesis"
] | [
18927
] | 1 | [
"EC",
"METACYC"
] | [
"2.3.1.274",
"PWY-5981"
] | [
"EC:2.3.1.274",
"METACYC:PWY-5981"
] | 2 | [
"1u7n",
"1vi1",
"6a1k"
] | 3 | [
"PUB00008131",
"PUB00008132"
] | [
"9642179",
"10464226"
] | [
"Transcriptional analysis of essential genes of the Escherichia coli fatty acid biosynthesis gene cluster by functional replacement with the analogous Salmonella typhimurium gene cluster.",
"Characterization of a Pseudomonas aeruginosa fatty acid biosynthetic gene cluster: purification of acyl carrier protein (AC... | [
1998,
1999
] | 2 | [] | [
"IPR012116",
"IPR012281"
] | 0 | 2 | 0 | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
18402,
56,
469
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Fatty acid synthesis PlsX protein | Fatty acid synthesis PlsX protein | FA_synthesis | 6 |
IPR003666 | 3,666 | Photosystem I PsaF, reaction centre subunit III | PSI_PsaF | Family | 1,655 | false | false | Photosystem I (PSI) is an integral membrane protein complex that uses light energy to mediate electron transfer from plastocyanin to ferredoxin. Subunit III (or PsaF) is one of at least 14 different subunits that compose the photosystem I reaction centre (PSI-RC) [ ]. | [
"GO:0015979",
"GO:0009522",
"GO:0009538"
] | [
"photosynthesis",
"photosystem I",
"photosystem I reaction center"
] | [
"biological_process",
"cellular_component",
"cellular_component"
] | 3 | [
"PFAM",
"PANTHER"
] | [
"PF02507",
"PTHR34939"
] | [
"PSI_PsaF",
""
] | [
1651,
1649
] | 2 | [
"GP"
] | [
"GenProp0660"
] | [
"GP:GenProp0660"
] | 1 | [
"1jb0",
"2o01",
"2wsc",
"2wse",
"2wsf",
"3lw5",
"3pcq",
"4fe1",
"4kt0",
"4l6v",
"4rku",
"4xk8",
"4y28",
"5l8r",
"5oy0",
"5zf0",
"5zgb",
"5zgh",
"5zji",
"6fos",
"6hqb",
"6igz",
"6ijj",
"6ijo",
"6jeo",
"6jo5",
"6jo6",
"6k33",
"6k61",
"6kif",
"6kig",
"6l35"... | 143 | [
"PUB00008134"
] | [
"8443351"
] | [
"Subunit III (Psa-F) of photosystem I reaction center of the C4 dicotyledon Flaveria trinervia."
] | [
1993
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"marine sediment metagenome"
] | [
411,
1236,
6,
2
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
4,
4,
4
] | 3 | true | Family | Photosystem I PsaF, reaction centre subunit III | Photosystem I PsaF, reaction centre subunit III | PSI_PsaF | 3 |
IPR003667 | 3,667 | NqrDE/RnfAE | NqrDE/RnfAE | Family | 22,719 | false | false | This is a family of integral membrane proteins including Rdf complex subunits RnfA and RnfE [ ] and Na+-translocating NADH:ubiquinone oxidoreductase (Na+-NQR) subunits NqrD and NqrE [ ]. The Rnf complex is a ferredoxin:NAD+ oxidoreductase that appears to translocate different ions (protons or sodium) in different bacte... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PFAM",
"PIRSF"
] | [
"PF02508",
"PIRSF006102"
] | [
"Rnf-Nqr",
"NQR_DE"
] | [
22675,
21755
] | 2 | [] | [] | [] | 0 | [
"7xk3",
"7xk4",
"7xk5",
"7xk6",
"7xk7",
"7zc6",
"8a1t",
"8a1u",
"8a1v",
"8a1w",
"8a1x",
"8a1y",
"8acw",
"8acy",
"8ad0",
"8ahx",
"8evu",
"8ew3",
"8rb8",
"8rb9",
"8rbm",
"8rbq",
"9eri",
"9erj",
"9erk",
"9erl",
"9lrr",
"9u5g",
"9ud2",
"9ud3",
"9ud4",
"9ud5"... | 39 | [
"PUB00007528",
"PUB00008135",
"PUB00013512",
"PUB00087510"
] | [
"9154934",
"9492268",
"11248187",
"27114876"
] | [
"Membrane localization, topology, and mutual stabilization of the rnfABC gene products in Rhodobacter capsulatus and implications for a new family of energy-coupling NADH oxidoreductases.",
"Overexpression in Escherichia coli of the rnf genes from Rhodobacter capsulatus--characterization of two membrane-bound iro... | [
1997,
1998,
2001,
2016
] | 4 | [] | [
"IPR010967",
"IPR010968",
"IPR011292",
"IPR011293"
] | 0 | 4 | 0 | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"unclassified sequences"
] | [
22069,
31,
83,
536
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | NqrDE/RnfAE | NqrDE/RnfAE | NqrDE/RnfAE | 4 |
IPR003668 | 3,668 | Rotavirus non-structural protein 2 | Rotavirus_NSP2 | Family | 2,656 | false | false | Rotavirus non-structural protein 2 (NSP2) is a basic protein which possesses RNA-binding activity and is essential for genome replication [ ]. It may also be important for viral RNA packaging. | [
"GO:0003723",
"GO:0019079"
] | [
"RNA binding",
"viral genome replication"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP"
] | [
"MF_04089"
] | [
"ROTA_NSP2"
] | [
2656
] | 1 | [
"EC",
"METACYC"
] | [
"3.6.4.-",
"PWY-7250"
] | [
"EC:3.6.4.-",
"METACYC:PWY-7250"
] | 2 | [
"1l9v",
"2gu0",
"2r7c",
"2r7j",
"2r7p",
"2r8f",
"4g0a",
"4g0j",
"6auk",
"6cy9",
"6cya",
"7pko",
"7pkp",
"8p00",
"9oft",
"9ogq"
] | 16 | [
"PUB00008136"
] | [
"8380660"
] | [
"Nucleotide and amino acid sequence analysis of the rotavirus nonstructural RNA-binding protein NS35."
] | [
1993
] | 1 | [] | [] | 0 | 0 | null | [
"Rotavirus"
] | [
2656
] | 1 | [] | [] | 0 | true | Family | Rotavirus non-structural protein 2 | Rotavirus non-structural protein 2 | Rotavirus_NSP2 | 5 |
IPR003669 | 3,669 | Thymidylate synthase ThyX | Thymidylate_synthase_ThyX | Family | 10,342 | false | false | All cellular organisms need thymidylate (dTMP) for the replication of their chromosomes, as dTMP is required for the biosynthesis of dTTP, a building block of DNA. Cells can produce thymidylate either de novo from dUMP or incorporate thymidine using thymidine kinase. The de novo pathway of dTMP synthesis requires a spe... | [
"GO:0050660",
"GO:0050797",
"GO:0006231"
] | [
"flavin adenine dinucleotide binding",
"thymidylate synthase (FAD) activity",
"dTMP biosynthetic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"HAMAP",
"PFAM",
"PROFILE",
"PANTHER",
"NCBIFAM",
"CDD"
] | [
"MF_01408",
"PF02511",
"PS51331",
"PTHR34934",
"TIGR02170",
"cd20175"
] | [
"ThyX",
"Thy1",
"THYX",
"",
"thyX",
"ThyX"
] | [
6098,
10319,
10148,
9796,
8036,
9582
] | 6 | [
"EC",
"METACYC"
] | [
"2.1.1.148",
"PWY-6545"
] | [
"EC:2.1.1.148",
"METACYC:PWY-6545"
] | 2 | [
"1kq4",
"1o24",
"1o25",
"1o26",
"1o27",
"1o28",
"1o29",
"1o2a",
"1o2b",
"2af6",
"2cfa",
"2gq2",
"3ah5",
"3fnn",
"3g4a",
"3g4c",
"3ge9",
"3gwc",
"3hzg",
"3n0b",
"3n0c",
"3n3y",
"4fzb",
"4gt9",
"4gta",
"4gtb",
"4gtc",
"4gtd",
"4gte",
"4gtf",
"4gtl",
"4kar"... | 49 | [
"PUB00015587",
"PUB00029306",
"PUB00035995",
"PUB00039996",
"PUB00043680",
"PUB00043681"
] | [
"15046578",
"12791256",
"15123820",
"16707489",
"12029065",
"12211025"
] | [
"Two distinct pathways for thymidylate (dTMP) synthesis in (hyper)thermophilic Bacteria and Archaea.",
"Functional analysis of substrate and cofactor complex structures of a thymidylate synthase-complementing protein.",
"Functional evidence for active site location of tetrameric thymidylate synthase X at the in... | [
2004,
2003,
2004,
2006,
2002,
2002
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
430,
7635,
61,
1597,
619
] | 5 | [] | [] | 0 | true | Family | Thymidylate synthase ThyX | Thymidylate synthase ThyX | Thymidylate_synthase_ThyX | 9 |
IPR003670 | 3,670 | African swine fever virus, TBK1 inhibitor DP96R | ASFV_DP96R | Family | 28 | false | false | This entry represents TBK1 inhibitor DP96R from African swine fever virus. DP96R is involved in virus immune evasion through the inhibition of the phosphorylation of the host proteins TBK1 and IKKB [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02512"
] | [
"UK"
] | [
28
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00100262"
] | [
"30348523"
] | [
"Inhibition of cGAS-STING-TBK1 signaling pathway by DP96R of ASFV China 2018/1."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"African swine fever virus"
] | [
28
] | 1 | [] | [] | 0 | true | Family | African swine fever virus, TBK1 inhibitor DP96R | African swine fever virus, TBK1 inhibitor DP96R | ASFV_DP96R | 5 |
IPR003671 | 3,671 | Spindlin/spermiogenesis-specific protein | SPIN/Ssty | Family | 2,804 | false | false | Spindlin (Spin) and Ssty were first identified for their involvement in gametogenesis. Spindlin was identified as a maternal transcript present in the unfertilised egg and early embryo, and was subsequently shown to interact with the spindle apparatus during oogenesis, and may therefore be important for mitosis [ ]. In... | [
"GO:0007276"
] | [
"gamete generation"
] | [
"biological_process"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF02513",
"PTHR10405"
] | [
"Spin-Ssty",
""
] | [
2796,
2739
] | 2 | [] | [] | [] | 0 | [
"2ns2",
"4h75",
"4mzf",
"4mzg",
"4mzh",
"4uy4",
"5a1h",
"5jsg",
"5jsj",
"5lug",
"5y5w",
"6i8b",
"6i8l",
"6i8y",
"6qpl",
"7bqz",
"7bu9",
"7cna",
"7e9m",
"7ea1",
"7ocb",
"8gtx",
"9t31"
] | 23 | [
"PUB00008139",
"PUB00016250",
"PUB00016251"
] | [
"9053325",
"11806826",
"15020475"
] | [
"Spindlin, a major maternal transcript expressed in the mouse during the transition from oocyte to embryo.",
"The Spin/Ssty repeat: a new motif identified in proteins involved in vertebrate development from gamete to embryo.",
"A new deletion of the mouse Y chromosome long arm associated with the loss of Ssty e... | [
1997,
2002,
2004
] | 3 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
2804
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
14,
71,
71
] | 4 | true | Family | Spindlin/spermiogenesis-specific protein | Spindlin/spermiogenesis-specific protein | SPIN/Ssty | 1 |
IPR003672 | 3,672 | CobN/magnesium chelatase | CobN/Mg_chltase | Domain | 12,462 | false | false | This entry contains a domain common to the cobN protein and to magnesium protoporphyrin chelatase. CobN may play a role in cobalt insertion reactions and is implicated in the conversion of precorrin-2 to cobyrinic acid in cobalamin biosynthesis [ ]. Magnesium protoporphyrin chelatase is involved in chlorophyll biosynth... | [
"GO:0009058"
] | [
"biosynthetic process"
] | [
"biological_process"
] | 1 | [
"PFAM",
"PANTHER",
"CDD"
] | [
"PF02514",
"PTHR44119",
"cd10150"
] | [
"CobN-Mg_chel",
"",
"CobN_like"
] | [
12405,
12394,
11186
] | 3 | [
"EC",
"METACYC",
"METACYC"
] | [
"6.6.1.1",
"PWY-5531",
"PWY-7159"
] | [
"EC:6.6.1.1",
"METACYC:PWY-5531",
"METACYC:PWY-7159"
] | 3 | [
"4zhj",
"5ewu",
"6ys9",
"6ysg",
"6yt0",
"6ytj",
"6ytn",
"7c6o",
"9d26",
"9fpc",
"9frc",
"9p4s"
] | 12 | [
"PUB00008140",
"PUB00008141"
] | [
"1655697",
"8385667"
] | [
"Nucleotide sequence and genetic analysis of a 13.1-kilobase-pair Pseudomonas denitrificans DNA fragment containing five cob genes and identification of structural genes encoding Cob(I)alamin adenosyltransferase, cobyric acid synthase, and bifunctional cobinamide kinase-cobinamide phosphate guanylyltransferase.",
... | [
1991,
1993
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
854,
10136,
1359,
113
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
3,
9,
12
] | 3 | true | Domain | CobN/magnesium chelatase | CobN/magnesium chelatase | CobN/Mg_chltase | 2 |
IPR003675 | 3,675 | CAAX prenyl protease 2/Lysostaphin resistance protein A-like domain | Rce1/LyrA-like_dom | Domain | 79,552 | false | false | This entry represents a domain found in CAAX prenyl protease 2 from Saccharomyces cerevisiae (RCE1), its human homologue, Lysostaphin resistance protein A from Staphylococcus aureus (LyrA), putative intramembrane proteases (IMPs), and similar sequences found in bacteria, eukaryotes and archaea. This domain shows an all... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02517"
] | [
"Rce1-like"
] | [
79552
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-5689880",
"R-BTA-9648002",
"R-CEL-5689880",
"R-CEL-9648002",
"R-DME-5689880",
"R-DME-9648002",
"R-HSA-5689880",
"R-HSA-9648002",
"R-MMU-5689880",
"R-MMU-9648002",
"R-RNO-5689880",
"R-RNO-9648002",
"R-SCE-5689880",
"R-SCE-9648002",
"R-SPO-5689880",
"R-SPO-9648002"
] | [
"REACTOME:R-BTA-5689880",
"REACTOME:R-BTA-9648002",
"REACTOME:R-CEL-5689880",
"REACTOME:R-CEL-9648002",
"REACTOME:R-DME-5689880",
"REACTOME:R-DME-9648002",
"REACTOME:R-HSA-5689880",
"REACTOME:R-HSA-9648002",
"REACTOME:R-MMU-5689880",
"REACTOME:R-MMU-9648002",
"REACTOME:R-RNO-5689880",
"REACTOM... | 16 | [
"4cad",
"6u0o"
] | 2 | [
"PUB00055945",
"PUB00090026",
"PUB00090027",
"PUB00095436",
"PUB00158975"
] | [
"20154137",
"29424242",
"24291792",
"16361710",
"33168989"
] | [
"The abi proteins and their involvement in bacteriocin self-immunity.",
"Rce1: mechanism and inhibition.",
"Mechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1.",
"Mutational analysis of the ras converting enzyme reveals a requirement for glutamate and histidine residues.",
... | [
2010,
2018,
2013,
2006,
2021
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"plasmids",
"unclassified sequences"
] | [
3606,
65695,
9423,
13,
2,
813
] | 6 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
52,
1,
30,
1,
4,
6,
2,
18,
7,
1,
1,
59
] | 12 | true | Domain | CAAX prenyl protease 2/Lysostaphin resistance protein A-like domain | CAAX prenyl protease 2/Lysostaphin resistance protein A-like domain | Rce1/LyrA-like_dom | 7 |
IPR003676 | 3,676 | Small auxin-up RNA | SAUR_fam | Family | 34,559 | false | false | This entry represents a group of plant auxin-responsive proteins, known as small auxin-up RNA (SAUR) [ ]. The first SAUR gene was originally identified in soybean hypocotyls [ ]. SAUR genes are mainly expressed in growing hypocotyls or other elongating tissues, implying that they play a role in the regulation of cell e... | [
"GO:0009733"
] | [
"response to auxin"
] | [
"biological_process"
] | 1 | [
"PFAM",
"PANTHER",
"PANTHER",
"PANTHER",
"PANTHER"
] | [
"PF02519",
"PTHR31175",
"PTHR31374",
"PTHR31929",
"PTHR35296"
] | [
"Auxin_inducible",
"",
"",
"",
""
] | [
33937,
4830,
15849,
10731,
2315
] | 5 | [] | [] | [] | 0 | [] | 0 | [
"PUB00074921",
"PUB00074922",
"PUB00074923"
] | [
"9278170",
"24277197",
"24858935"
] | [
"Regulatory activity exerted by the SAUR-AC1 promoter region in transgenic plants.",
"Characterization of a class of small auxin-inducible soybean polyadenylated RNAs.",
"SAUR Inhibition of PP2C-D Phosphatases Activates Plasma Membrane H+-ATPases to Promote Cell Expansion in Arabidopsis."
] | [
1997,
1987,
2014
] | 3 | [] | [] | 0 | 0 | null | [
"Streptophytina"
] | [
34559
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
252,
149,
237
] | 3 | true | Family | Small auxin-up RNA | Small auxin-up RNA | SAUR_fam | 2 |
IPR003677 | 3,677 | SXP/RAL-2 family protein Ani s 5-like, cation-binding domain | ANIS5_cation-bd | Domain | 1,722 | false | false | This domain is found in proteins from nematodes, including SXP/RAL-2 family protein Ani s 5 (ANIS5) from Anisakis simplex, and comprises two conserved motifs: SXP1 and SXP2 [ ]. Although the function of this domain is not clear, structural information from ANIS5 revealed an α helical arrangement with a Calmodulin-like ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02520"
] | [
"ANIS5_cation-bd"
] | [
1722
] | 1 | [] | [] | [] | 0 | [
"2mar"
] | 1 | [
"PUB00097763",
"PUB00097764"
] | [
"33371317",
"24603892"
] | [
"Identification and Physicochemical Characterization of a New Allergen from <i>Ascaris lumbricoides</i>.",
"Relationships between IgE/IgG4 epitopes, structure and function in Anisakis simplex Ani s 5, a member of the SXP/RAL-2 protein family."
] | [
2020,
2014
] | 2 | [] | [] | 0 | 0 | null | [
"Protostomia",
"Pseudoalteromonas prydzensis"
] | [
1721,
1
] | 2 | [
"Caenorhabditis elegans"
] | [
40
] | 1 | true | Domain | SXP/RAL-2 family protein Ani s 5-like, cation-binding domain | SXP/RAL-2 family protein Ani s 5-like, cation-binding domain | ANIS5_cation-bd | 4 |
IPR003678 | 3,678 | Putative outer membrane protein | Put_OMP | Family | 1,119 | false | false | Helicobacter pylori is a causative agent of gastritis and peptic ulceration in humans. As the first step towards development of a vaccine against H. pylori infection, many attempts have been made to identify protective antigens. Potential targets for vaccine development are H. pylori-specific proteins that are surface-... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02521"
] | [
"HP_OMP_2"
] | [
1119
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Pseudomonadati"
] | [
1119
] | 1 | [] | [] | 0 | true | Family | Putative outer membrane protein | Putative outer membrane protein | Put_OMP | 4 |
IPR003679 | 3,679 | Aminoglycoside N(3)-acetyltransferase-like | Amioglycoside_AcTrfase | Family | 4,936 | false | false | This family consists of bacterial aminoglycoside N(3)-acetyltransferases ( ) that catalyse the reaction [ ]: Acetyl-Co + a 2-deoxystreptamine antibiotic = CoA + N3'-acetyl-2-deoxystreptamine antibiotic . The enzyme can use a range of antibiotics with 2-deoxystreptamine rings as acceptor for its acetyltransferase activi... | [
"GO:0008080",
"GO:0046677"
] | [
"N-acetyltransferase activity",
"response to antibiotic"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF02522",
"PTHR11104"
] | [
"Antibiotic_NAT",
""
] | [
4935,
4741
] | 2 | [
"EC"
] | [
"2.3.1.81"
] | [
"EC:2.3.1.81"
] | 1 | [
"2nyg",
"3e4f",
"3ijw",
"3kzl",
"3n0m",
"3n0s",
"3slb",
"3slf",
"3sma",
"5ht0",
"6bbr",
"6bbz",
"6bc2",
"6bc3",
"6bc4",
"6bc5",
"6bc6",
"6bc7",
"6mb4",
"6mb5",
"6mb6",
"6mb7",
"6mb8",
"6mb9",
"6mmz",
"6mn0",
"6mn1",
"6mn2",
"6mn3",
"6mn4",
"6mn5",
"6np1"... | 49 | [
"PUB00008152",
"PUB00008153",
"PUB00065632"
] | [
"1761222",
"9766465",
"21865168"
] | [
"Nucleotide sequence and transcriptional start point of the kan gene encoding an aminoglycoside 3-N-acetyltransferase from Streptomyces griseus SS-1198PR.",
"The novel enzymatic 3''-N-acetylation of arbekacin by an aminoglycoside 3-N-acetyltransferase of Streptomyces origin and the resulting activity.",
"New N-... | [
1991,
1998,
2011
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacillus phage SPbeta",
"Bacteria",
"Eukaryota",
"Plasmid R",
"unclassified sequences"
] | [
176,
1,
4532,
171,
1,
55
] | 6 | [
"Arabidopsis thaliana"
] | [
1
] | 1 | true | Family | Aminoglycoside N(3)-acetyltransferase-like | Aminoglycoside N(3)-acetyltransferase-like | Amioglycoside_AcTrfase | 3 |
IPR003680 | 3,680 | Flavodoxin-like fold | Flavodoxin_fold | Domain | 49,388 | false | false | This entry represents a domain with a flavodoxin-like fold. Proteins with this domain include bacterial and eukaryotic NAD(P)H dehydrogenase (quinone) . These enzymes catalyse the NAD(P)H-dependent two-electron reductions of quinones and protect cells against damage by free radicals and reactive oxygen species [ ]. Thi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02525"
] | [
"Flavodoxin_2"
] | [
49388
] | 1 | [
"EC",
"EC",
"EC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.6.5",
"1.6.5.-",
"1.7.1.17",
"PWY-2261",
"PWY-6370",
"R-HSA-211945",
"R-HSA-350562",
"R-HSA-9818027",
"R-MMU-211945",
"R-MMU-350562",
"R-RNO-211945",
"R-RNO-350562"
] | [
"EC:1.6.5",
"EC:1.6.5.-",
"EC:1.7.1.17",
"METACYC:PWY-2261",
"METACYC:PWY-6370",
"REACTOME:R-HSA-211945",
"REACTOME:R-HSA-350562",
"REACTOME:R-HSA-9818027",
"REACTOME:R-MMU-211945",
"REACTOME:R-MMU-350562",
"REACTOME:R-RNO-211945",
"REACTOME:R-RNO-350562"
] | 12 | [
"1d4a",
"1dxo",
"1dxq",
"1gg5",
"1h66",
"1h69",
"1kbo",
"1kbq",
"1qbg",
"1qr2",
"1qrd",
"1sg0",
"1t5b",
"1tik",
"1v4b",
"1xi2",
"1zx1",
"2amj",
"2b3d",
"2bzs",
"2d5i",
"2f1o",
"2hpv",
"2qmy",
"2qmz",
"2qr2",
"2qwx",
"2qx4",
"2qx6",
"2qx8",
"2qx9",
"2v9c"... | 146 | [
"PUB00008154",
"PUB00017182"
] | [
"7568029",
"2168383"
] | [
"The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction.",
"Isolation and properties of acyl carrier protein phosphodiesterase of Escherichia coli."
] | [
1995,
1990
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Sym plasmid",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
129,
46202,
2811,
1,
2,
243
] | 6 | [
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
5,
12,
8,
8,
1
] | 6 | true | Domain | Flavodoxin-like fold | Flavodoxin-like fold | Flavodoxin_fold | 1 |
IPR003681 | 3,681 | Glycophorin-binding protein | Glycophorin-bd | Repeat | 57 | false | false | The glycophorin-binding protein contains a tandem repeat. The repeated sequence determines the binding domain for an erythrocyte receptor binding protein of Plasmodium falciparum, the malarial parasite [ , ]. Erythrocyte invasion by the malarial merozoite is a receptor-mediated process, an obligatory step in the develo... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE"
] | [
"PF02526",
"PS51069"
] | [
"GBP_repeat",
"GBP"
] | [
57,
57
] | 2 | [
"PROSITEDOC"
] | [
"PDOC51069"
] | [
"PROSITEDOC:PDOC51069"
] | 1 | [] | 0 | [
"PUB00015009",
"PUB00018523"
] | [
"7891744",
"10904405"
] | [
"Isolation of a third member of the Plasmodium falciparum glycophorin-binding protein gene family.",
"A GBP 130 derived peptide from Plasmodium falciparum binds to human erythrocytes and inhibits merozoite invasion in vitro."
] | [
1994,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Plasmodium (Laverania)"
] | [
57
] | 1 | [] | [] | 0 | true | Repeat | Glycophorin-binding protein | Glycophorin-binding protein | Glycophorin-bd | 2 |
IPR003682 | 3,682 | rRNA small subunit methyltransferase G | rRNA_ssu_MeTfrase_G | Family | 26,001 | false | false | This entry represents a rRNA small subunit methyltransferase G. Previously identified as a glucose-inhibited division protein B that appears to be present and in a single copy in all complete eubacterial genomes so far sequenced. Specifically methylates the N7 position of a guanosine in 16S rRNA [ , , ]. | [
"GO:0008649",
"GO:0006364",
"GO:0005737"
] | [
"rRNA methyltransferase activity",
"rRNA processing",
"cytoplasm"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"HAMAP",
"PFAM",
"PIRSF",
"PANTHER",
"NCBIFAM"
] | [
"MF_00074",
"PF02527",
"PIRSF003078",
"PTHR31760",
"TIGR00138"
] | [
"16SrRNA_methyltr_G",
"GidB",
"GidB",
"",
"rsmG_gidB"
] | [
25519,
25964,
19784,
25880,
24894
] | 5 | [
"EC",
"GP"
] | [
"2.1.1",
"GenProp0802"
] | [
"EC:2.1.1",
"GP:GenProp0802"
] | 2 | [
"1jsx",
"1xdz",
"3g88",
"3g89",
"3g8a",
"3g8b",
"7cfe"
] | 7 | [
"PUB00017368",
"PUB00045520",
"PUB00052558"
] | [
"12001236",
"17238915",
"17573471"
] | [
"Crystal structure of the Escherichia coli glucose-inhibited division protein B (GidB) reveals a methyltransferase fold.",
"Loss of a conserved 7-methylguanosine modification in 16S rRNA confers low-level streptomycin resistance in bacteria.",
"Identification of the RsmG methyltransferase target as 16S rRNA nuc... | [
2002,
2007,
2007
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
2,
24607,
859,
533
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
8,
1,
4,
7
] | 4 | true | Family | rRNA small subunit methyltransferase G | rRNA small subunit methyltransferase G | rRNA_ssu_MeTfrase_G | 9 |
IPR003683 | 3,683 | Cytochrome b6/f complex, subunit 5 | Cyt_6/f_cplx_su5 | Family | 13,608 | false | false | This family consists of cytochrome b6/f complex subunit 5 (PetG). The cytochrome bf complex, found in green plants, eukaryotic algae and cyanobacteria, connects photosystem I to photosystem II in the electron transport chain, functioning as a plastoquinol:plastocyanin/cytochrome c6 oxidoreductase [ ]. The purified comp... | [
"GO:0009512"
] | [
"cytochrome b6f complex"
] | [
"cellular_component"
] | 1 | [
"HAMAP",
"PFAM",
"PIRSF"
] | [
"MF_00432",
"PF02529",
"PIRSF000034"
] | [
"Cytb6_f_PetG",
"PetG",
"Cyt_b6-f_V"
] | [
13445,
13608,
13356
] | 3 | [
"GP"
] | [
"GenProp1353"
] | [
"GP:GenProp1353"
] | 1 | [
"1q90",
"1vf5",
"2d2c",
"2e74",
"2e75",
"2e76",
"2zt9",
"4h0l",
"4h13",
"4h44",
"4i7z",
"4ogq",
"4pv1",
"6rqf",
"7qrm",
"7r0w",
"7zxy",
"7zyv",
"9es7",
"9es8",
"9es9"
] | 21 | [
"PUB00008158",
"PUB00008159"
] | [
"7493961",
"7493968"
] | [
"The deletion of petG in Chlamydomonas reinhardtii disrupts the cytochrome bf complex.",
"Purification and characterization of the cytochrome b6 f complex from Chlamydomonas reinhardtii."
] | [
1995,
1995
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine metagenome"
] | [
320,
13287,
1
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
3,
3,
2
] | 3 | true | Family | Cytochrome b6/f complex, subunit 5 | Cytochrome b6/f complex, subunit 5 | Cyt_6/f_cplx_su5 | 6 |
IPR003684 | 3,684 | Porin, alpha proteobacteria type | Porin_alphabac | Family | 3,912 | false | false | This family consists of porins from the alpha subdivision of Proteobacteria. Members of this family are related to Gram-negative porins [ ], including Porin Omp2a/b from Brucella [ ]. The porins form large aqueous channels in the cell membrane allowing the selective entry of hydrophilic compounds this so called 'molecu... | [
"GO:0015288",
"GO:0055085",
"GO:0016020"
] | [
"porin activity",
"transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM"
] | [
"PF02530"
] | [
"Porin_2"
] | [
3912
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00008161",
"PUB00098646"
] | [
"1370281",
"11466287"
] | [
"Cloning, nucleotide sequencing, and expression in Escherichia coli of a Rhizobium leguminosarum gene encoding a symbiotically repressed outer membrane protein.",
"Molecular, antigenic, and functional analyses of Omp2b porin size variants of Brucella spp."
] | [
1992,
2001
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"ecological metagenomes"
] | [
3889,
9,
10,
4
] | 4 | [] | [] | 0 | true | Family | Porin, alpha proteobacteria type | Porin, alpha proteobacteria type | Porin_alphabac | 4 |
IPR003685 | 3,685 | Photosystem I PsaD | PsaD | Family | 1,740 | false | false | PsaD is a small, extrinsic polypeptide located on the stromal side (cytoplasmic side in cyanobacteria) of the photosystem I reaction centre complex. It is required for native assembly of PSI reaction clusters and is implicated in the electrostatic binding of ferredoxin within the reaction centre [ ]. PsaD forms a dimer... | [
"GO:0015979",
"GO:0009522",
"GO:0009538"
] | [
"photosynthesis",
"photosystem I",
"photosystem I reaction center"
] | [
"biological_process",
"cellular_component",
"cellular_component"
] | 3 | [
"PFAM",
"PANTHER"
] | [
"PF02531",
"PTHR31982"
] | [
"PsaD",
""
] | [
1726,
1723
] | 2 | [
"GP"
] | [
"GenProp0660"
] | [
"GP:GenProp0660"
] | 1 | [
"1jb0",
"2o01",
"2wsc",
"2wse",
"2wsf",
"3lw5",
"3pcq",
"4fe1",
"4kt0",
"4l6v",
"4rku",
"4xk8",
"4y28",
"5l8r",
"5oy0",
"5zf0",
"5zgb",
"5zgh",
"5zji",
"6fos",
"6hqb",
"6igz",
"6ijj",
"6ijo",
"6jeo",
"6jo5",
"6jo6",
"6k33",
"6k61",
"6kif",
"6kig",
"6kmw"... | 146 | [
"PUB00008162"
] | [
"9692933"
] | [
"Structure and properties in solution of PsaD, an extrinsic polypeptide of photosystem I."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
380,
1341,
5,
14
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
6,
3,
8
] | 3 | true | Family | Photosystem I PsaD | Photosystem I PsaD | PsaD | 9 |
IPR003686 | 3,686 | Photosystem II PsbI | PSII_PsbI | Family | 13,900 | false | false | Oxygenic photosynthesis uses two multi-subunit photosystems (I and II) located in the cell membranes of cyanobacteria and in the thylakoid membranes of chloroplasts in plants and algae. Photosystem II (PSII) has a P680 reaction centre containing chlorophyll 'a' that uses light energy to carry out the oxidation (splitti... | [
"GO:0015979",
"GO:0009523",
"GO:0009539",
"GO:0016020"
] | [
"photosynthesis",
"photosystem II",
"photosystem II reaction center",
"membrane"
] | [
"biological_process",
"cellular_component",
"cellular_component",
"cellular_component"
] | 4 | [
"HAMAP",
"PFAM",
"PANTHER"
] | [
"MF_01316",
"PF02532",
"PTHR35772"
] | [
"PSII_PsbI",
"PsbI",
""
] | [
13765,
13900,
13815
] | 3 | [
"GP"
] | [
"GenProp0661"
] | [
"GP:GenProp0661"
] | 1 | [
"1s5l",
"2axt",
"3a0b",
"3a0h",
"3jcu",
"3kzi",
"3wu2",
"4fby",
"4il6",
"4ixq",
"4ixr",
"4pbu",
"4pj0",
"4rvy",
"4tnh",
"4tni",
"4tnj",
"4tnk",
"4ub6",
"4ub8",
"4v62",
"4v82",
"4yuu",
"5b5e",
"5b66",
"5e79",
"5e7c",
"5gth",
"5gti",
"5h2f",
"5kaf",
"5kai"... | 166 | [
"PUB00008166",
"PUB00015357",
"PUB00015358",
"PUB00015359",
"PUB00097583",
"PUB00152828"
] | [
"8544827",
"12518057",
"15100025",
"14871485",
"30076221",
"33846594"
] | [
"Directed inactivation of the psbI gene does not affect photosystem II in the cyanobacterium Synechocystis sp. PCC 6803.",
"Crystal structure of oxygen-evolving photosystem II from Thermosynechococcus vulcanus at 3.7-A resolution.",
"The evolutionary development of the protein complement of photosystem 2.",
"... | [
1995,
2003,
2004,
2004,
2018,
2021
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
327,
13573
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
2,
5,
2
] | 3 | true | Family | Photosystem II PsbI | Photosystem II PsbI | PSII_PsbI | 5 |
IPR003687 | 3,687 | Photosystem II PsbK | PSII_PsbK | Family | 14,226 | false | false | Oxygenic photosynthesis uses two multi-subunit photosystems (I and II) located in the cell membranes of cyanobacteria and in the thylakoid membranes of chloroplasts in plants and algae. Photosystem II (PSII) has a P680 reaction centre containing chlorophyll 'a' that uses light energy to carry out the oxidation (splitti... | [
"GO:0015979",
"GO:0009523",
"GO:0009539"
] | [
"photosynthesis",
"photosystem II",
"photosystem II reaction center"
] | [
"biological_process",
"cellular_component",
"cellular_component"
] | 3 | [
"HAMAP",
"NCBIFAM",
"PFAM",
"PANTHER"
] | [
"MF_00441",
"NF002715",
"PF02533",
"PTHR35325"
] | [
"PSII_PsbK",
"PRK02553.1",
"PsbK",
""
] | [
13854,
13874,
14210,
14121
] | 4 | [
"GP"
] | [
"GenProp0661"
] | [
"GP:GenProp0661"
] | 1 | [
"1izl",
"1s5l",
"2axt",
"3a0b",
"3a0h",
"3jcu",
"3kzi",
"3wu2",
"4fby",
"4il6",
"4ixq",
"4ixr",
"4pbu",
"4pj0",
"4rvy",
"4tnh",
"4tni",
"4tnj",
"4tnk",
"4ub6",
"4ub8",
"4v62",
"4v82",
"4yuu",
"5b5e",
"5b66",
"5e79",
"5e7c",
"5gth",
"5gti",
"5h2f",
"5kaf"... | 164 | [
"PUB00008165",
"PUB00015357",
"PUB00015358",
"PUB00015359",
"PUB00015368",
"PUB00097583",
"PUB00152828"
] | [
"9632665",
"12518057",
"15100025",
"14871485",
"12939265",
"30076221",
"33846594"
] | [
"Isolation and characterization of monomeric and dimeric CP47-reaction center photosystem II complexes.",
"Crystal structure of oxygen-evolving photosystem II from Thermosynechococcus vulcanus at 3.7-A resolution.",
"The evolutionary development of the protein complement of photosystem 2.",
"The low molecular... | [
1998,
2003,
2004,
2004,
2003,
2018,
2021
] | 7 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
343,
13883
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
5,
6,
5
] | 3 | true | Family | Photosystem II PsbK | Photosystem II PsbK | PSII_PsbK | 1 |
IPR003688 | 3,688 | Type IV secretion system protein TraG/VirD4 | TraG/VirD4 | Family | 18,410 | false | false | This entry represents type IV secretion system proteins TraG and VirD4. TraG-like proteins are potential NTP hydrolases (NTPases) that are essential for DNA transfer in bacterial conjugation. They are thought to mediate interactions between the DNA-processing (Dtr) and the mating pair formation (Mpf) systems [ , ]. Tra... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF02534"
] | [
"T4SS-DNA_transf"
] | [
18410
] | 1 | [] | [] | [] | 0 | [
"6jho",
"8dol"
] | 2 | [
"PUB00020458",
"PUB00078705",
"PUB00078708",
"PUB00078709"
] | [
"11976307",
"2541431",
"11952902",
"10692358"
] | [
"TraG-like proteins of DNA transfer systems and of the Helicobacter pylori type IV secretion system: inner membrane gate for exported substrates?",
"The virD operon of Agrobacterium tumefaciens Ti plasmid encodes a DNA-relaxing enzyme.",
"Polar location and functional domains of the Agrobacterium tumefaciens DN... | [
2002,
1989,
2002,
2000
] | 4 | [] | [
"IPR014135"
] | 0 | 1 | 0 | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"Methanobacteriati",
"plasmids",
"unclassified sequences"
] | [
18116,
9,
56,
24,
8,
197
] | 6 | [] | [] | 0 | true | Family | Type IV secretion system protein TraG/VirD4 | Type IV secretion system protein TraG/VirD4 | TraG/VirD4 | 8 |
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